CN109229878A - sample container and sample processing device - Google Patents
sample container and sample processing device Download PDFInfo
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- CN109229878A CN109229878A CN201810847737.5A CN201810847737A CN109229878A CN 109229878 A CN109229878 A CN 109229878A CN 201810847737 A CN201810847737 A CN 201810847737A CN 109229878 A CN109229878 A CN 109229878A
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- holding tank
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2577/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks, bags
- B65D2577/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D2577/041—Details of two or more containers disposed one within another
- B65D2577/042—Comprising several inner containers
- B65D2577/043—Comprising several inner containers arranged side by side
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Mechanical Engineering (AREA)
- Hydrology & Water Resources (AREA)
- Engineering & Computer Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
This disclosure relates to a kind of sample container and sample processing device, the sample container includes container ontology, arranged for interval has multiple holding tank groups in the width direction on container ontology, and each holding tank group includes along the spaced apart sampling hammerhead holding tank in nucleic acid extraction direction and sample holding tank.Thus during sample extraction, by the position that nucleic acid extraction mechanism is moved to the corresponding sampling hammerhead holding tank of each holding tank group, the position of corresponding each sample holding tank is moved to after so that nucleic acid extraction mechanism is loaded the multiple sampling hammerheads being arranged in sampling hammerhead holding tank and synchronizes the nucleic acid extraction operation for executing multiple groups sample, or, pass through mobile sample container, nucleic acid extraction mechanism is set to go up and down in the height direction and sampling hammerhead is driven to be inserted into every group of corresponding sample holding tank simultaneously, execute the nucleic acid extraction operation of multiple groups, save the efficiency of loading that multiple groups sample executes the required time of nucleic acid extraction and shortens sampling hammerhead, effectively increase nucleic acid extraction efficiency.
Description
Technical field
This disclosure relates to sample process technical field, and in particular, to a kind of sample container and sample processing device.
Background technique
Nucleic acid extraction operation usually is executed using sample container and nucleic acid extraction mechanism in the extraction process such as nucleic acid,
That is, by the driving of nucleic acid extraction mechanism so that being loaded in nucleic acid extraction mechanism and the sampling hammerhead for accommodating sample is inserted into
In sample container, so that the sample in sampling hammerhead reacts with the reagent solution in sample container, core is thus executed
Acid extracts operation.Therefore, how to improve sample extraction efficiency by optimizing the structure and function of sample container is in nucleic acid
Research topic very popular in extractive technique field.
Summary of the invention
Hold purpose of this disclosure is to provide a kind of sample container that can be improved sample extraction efficiency and including the sample
Receive the sample processing device of device.
To achieve the goals above, according to one aspect of the disclosure, a kind of sample container is provided, the sample accommodates
Device includes container ontology, and arranged for interval has multiple holding tank groups, each appearance in the width direction on the container ontology
Slot group of receiving includes along the spaced apart sampling hammerhead holding tank in nucleic acid extraction direction and sample holding tank.
Optionally, each holding tank group includes successively taking described in spaced apart one along the nucleic acid extraction direction
Sample pipette tips holding tank and multiple sample holding tanks.
It optionally, will be in the nucleic acid extraction direction for multiple sample holding tanks of each holding tank group
The upper sample holding tank positioned at most downstream is defined as first sample holding tank, and described first will be removed on the nucleic acid extraction direction
Remaining sample holding tank except sample holding tank is defined as the second sample holding tank, the first sample holding tank and described takes
Sample pipette tips holding tank is located at the two sides of the second sample holding tank, and the groove depth of the first sample holding tank is less than described
The groove depth of second sample holding tank.
Optionally, for each holding tank group, the side wall of multiple second sample holding tanks is mentioned along the nucleic acid
Direction is taken successively to be adjacently positioned, the sampling hammerhead holding tank and the first sample holding tank are on the nucleic acid extraction direction
Most upstream and most downstream are spaced on multiple second sample holding tanks respectively.
Optionally, multiple second sample holding tanks are formed as identical structure and top and bottom end are located at same put down
On face, the top of the first sample holding tank and the top of the sampling hammerhead holding tank are lower than described the in the height direction
The top of two sample holding tanks.
Optionally, the sample container includes the upper lid that can be opened and closed to connect with the container ontology, it is described on
Portion's cover includes up and down and along the upper lid side wall made of all around, and the upper lid side wall is interior along the width direction interval
It is disposed with partition, the partition extends along the nucleic acid extraction direction respectively, with the shape between the every two adjacent partition
It is described under the upper lid and the lid conjunction state of the container ontology at sampling channel corresponding with each holding tank group
Partition separates the every two adjacent holding tank group along the width direction.
Optionally, the upper lid correspond to each sampling hammerhead holding tank position on be respectively arranged with it is described
The sampling hammerhead guide groove of sampling hammerhead holding tank connection, the bottom end of the sampling hammerhead guide groove can respectively accordingly with institute
The top for stating sampling hammerhead holding tank is engaged by clamping.
Optionally, there is each sampling hammerhead guide groove the connection being connected to corresponding sampling channel to open
Mouthful, for being open for sampling hammerhead across the connection.
Optionally, the container ontology includes horizontally disposed level board and the periphery for being arranged around the level board
This body sidewall be respectively disposed on the level board along vertical so that the accommodating chamber ontology is formed as recessed heavy formula structure
In the holding tank group for the tubulose that the vertical direction of the level board extends, the top of each holding tank group is from the water
At least part of top of the prominent and described sample holding tank is higher than described body sidewall on plate.
Optionally, it is formed with protruding outward on the top of described body sidewall for snapping fit onto the intracorporal anticreep of microscope carrier shell
From chuck.
According to another aspect of the present disclosure, a kind of sample processing device is provided, the sample processing device includes that nucleic acid mentions
Mechanism and sample container as described above are taken, the nucleic acid extraction mechanism is movably set as, and is inserted into the sample
For extracting nucleic acid in each holding tank group of this container.
Through the above technical solutions, that is, using nucleic acid extraction mechanism during sample extraction, it can be by the way that nucleic acid be mentioned
The relative movement of mechanism and sample container is taken to execute nucleic acid extraction operation, it specifically, can be by by nucleic acid extraction mechanism
It is moved to the position of the corresponding sampling hammerhead holding tank of each holding tank group, so that nucleic acid extraction mechanism loads each sampling simultaneously
The sampling hammerhead being arranged in pipette tips holding tank, is moved to the position of the corresponding sample holding tank of each holding tank group and primary later
Property synchronously execute the nucleic acid extraction operations of multiple groups, alternatively, can be by mobile sample container, while making nucleic acid extraction machine
Structure is gone up and down in the height direction, makes it that the sampling hammerhead loaded in nucleic acid extraction mechanism be driven to be inserted into sample container corresponding
In sample holding tank, thereby executing the nucleic acid extraction operation of multiple groups, the institute of nucleic acid extraction is executed thus, it is possible to save multiple samples
It takes time, and can shorten nucleic acid extraction mechanism since each holding tank group contains sampling hammerhead holding tank and load sampling
The efficiency of loading of pipette tips, and then effectively increase nucleic acid extraction efficiency.
Other feature and advantage of the disclosure will the following detailed description will be given in the detailed implementation section.
Detailed description of the invention
Attached drawing is and to constitute part of specification for providing further understanding of the disclosure, with following tool
Body embodiment is used to explain the disclosure together, but does not constitute the limitation to the disclosure.In the accompanying drawings:
Fig. 1 is the lid conjunction state perspective view one according to the sample container of disclosure specific embodiment；
Fig. 2 is the lid conjunction state perspective view two according to the sample container of disclosure specific embodiment；
Fig. 3 is the top perspective view according to container ontology in the sample container of disclosure specific embodiment；
Fig. 4 is the face upwarding stereogram according to container ontology in the sample container of disclosure specific embodiment；
Fig. 5 is the top view of Fig. 3；
Fig. 6 is the schematic cross-sectional view in Fig. 5 along line A-A cutting, wherein eliminating section to clearly show that each structure
Line；
Fig. 7 is the top perspective view covered according to the sample container middle and upper part of disclosure specific embodiment；
The face upwarding stereogram that Fig. 8 is covered according to the sample container middle and upper part of disclosure specific embodiment；
Fig. 9 is the top view covered according to the sample container middle and upper part of disclosure specific embodiment；
Figure 10 is the cross-sectional view in Fig. 9 along line B-B cutting.
Description of symbols
3- sample container, 30- container ontology, 301- level board, this body sidewall of 302-, the anti-detachment chuck of 303-, 31-
Sampling hammerhead holding tank, 311- supporting rib, 32- sample holding tank, 321- first sample holding tank, the second sample of 322- accommodate
Slot, 33- upper lid, 331- upper lid side wall, 332- partition, 333- sample channel, 334- sampling hammerhead guide groove, and 335- connects
Open up mouth, Y- width direction, Z2- nucleic acid extraction direction.
Specific embodiment
It is described in detail below in conjunction with specific embodiment of the attached drawing to the disclosure.It should be understood that this place is retouched
The specific embodiment stated is only used for describing and explaining the disclosure, is not limited to the disclosure.
In the disclosure, in the absence of explanation to the contrary, the noun of locality used such as " inside and outside " refers to for corresponding portion
" inside and outside " of part profile, " upper and lower " and " top, bottom end " refer to the corresponding component of sample container in a state of use
" upper and lower " and " top, bottom end ", " width direction " and " nucleic acid extraction direction " typically refer to diagram side shown in Fig. 5 and Fig. 9
To Y and Z2, specifically, nucleic acid extraction direction can be accommodated for sample from the sampling hammerhead holding tank of sample container towards sample
The direction of slot executes the direction of nucleic acid extraction.
As shown in Figures 3 to 6, according to one aspect of the disclosure, a kind of sample container 3 is provided, the sample accommodates
Device 3 includes container ontology 30, and Y arranged for interval has multiple holding tank groups in the width direction on the container ontology 30, each
The holding tank group includes along the spaced apart sampling hammerhead holding tank 31 of nucleic acid extraction direction Z2 and sample holding tank 32.?
This, is due to being disposed with multiple holding tank groups with sampling hammerhead holding tank 31 and sample holding tank 32 on container ontology 30,
Wherein, sampling hammerhead holding tank 31 is for accommodating sampling hammerhead, and sample holding tank 32 when accommodating nucleic acid extraction for using
Reagent solution.It, can be by by nucleic acid using nucleic acid extraction mechanism during sample extraction by structure as described above
The relative movement of extraction mechanism and sample container executes nucleic acid extraction operation, specifically, can be by by nucleic acid extraction machine
Structure is moved to the position of the corresponding sampling hammerhead holding tank 31 of each holding tank group, so that nucleic acid extraction mechanism loads each simultaneously
The sampling hammerhead being arranged in sampling hammerhead holding tank 31, is moved to the position of the corresponding sample holding tank 32 of each holding tank group later
It sets and the disposable nucleic acid extraction operation for synchronously executing multiple groups, alternatively, sample container 3 can be moved, while making nucleic acid
Extraction mechanism is gone up and down in the height direction, makes it that the sampling hammerhead loaded in nucleic acid extraction mechanism be driven to be inserted into sample container
In 3 corresponding sample holding tanks 32, thereby executing the nucleic acid extraction operation of multiple groups, thus, it is possible to save multiple samples to execute nucleic acid
The required time of extraction, and nucleic acid extraction machine can be shortened since each holding tank group contains sampling hammerhead holding tank 31
Structure loads the efficiency of loading of sampling hammerhead, and then effectively increases nucleic acid extraction efficiency.In addition, in existing middle execution nucleic acid extraction
Before, after generally each sample being dispensed into the corresponding slot position of sample holding tank 32, the sampling of used dispensing is abandoned
Pipette tips result in waste of resources, and thus the sample container 3 of the disclosure is being dispensed due to being provided with sampling hammerhead holding tank 31
Used every group of dispensing can be placed into corresponding sampling hammerhead of sample container 3 after sample with sampling hammerhead
In holding tank 31, the sample extraction for being used as sample extraction is recycled without directly abandoning the dispensing with sampling hammerhead
Sampling hammerhead thereby saves sample extraction cost.
Optionally, as shown in Figure 3 and Figure 4, each holding tank group include along the nucleic acid extraction direction Z2 successively between
Every the sampling hammerhead holding tank 31 and multiple sample holding tanks 32 of arrangement.Here, sample holding tank 32 is for example
It may include the slot for accommodating lysate, cleaning solution, eluent etc., but it's not limited to that for the disclosure, it can be according to reality
Situation is extracted reasonably to select each reagent solution to be held of sample holding tank 32.Thus, it is possible to pass through nucleic acid extraction
Relative motion between mechanism and sample container 3 successively executes the nucleic acid extractions operations such as sample cracking, washing, elution, tool
There are nucleic acid extraction operation easy to carry out, easy to operate effect.It wherein, can on the medial surface of the sampling hammerhead holding tank 31
To be provided with multiple supporting ribs 311 circumferentially spacedly, it is set to be generally in vertical state to be used to support sampling hammerhead, thus
So that nucleic acid extraction mechanism easy to quickly loads sampling hammerhead, efficiency of loading is further increased.
It optionally, will be described as shown in figure 4, multiple sample holding tanks 32 for each holding tank group
Sample holding tank on the Z2 of nucleic acid extraction direction positioned at most downstream is defined as first sample holding tank 321, will mention in the nucleic acid
Remaining sample holding tank on the Z2 of direction in addition to the first sample holding tank 321 is taken to be defined as the second sample holding tank 322,
The first sample holding tank 321 and the sampling hammerhead holding tank 31 are located at the two of the second sample holding tank 322
Side, the groove depth of the first sample holding tank 321 are less than the groove depth of the second sample holding tank 322.Wherein, first sample is held
Slot 321 of receiving is used as the nucleic acid holding tank for accommodating the nucleic acid extracted from sample, can accommodate in the second sample holding tank 321
Each reagent solution such as lysate, cleaning solution, eluent for extracting nucleic acid, for example, second sample of each group accommodates
Slot 321 can be set just like Fig. 3 to five shown in fig. 6, wherein every group of second sample holding tank 321 may include for accommodating
First lysate holding tank of cell pyrolysis liquid, the second lysate holding tank for accommodating the lysate containing protein kinase,
For accommodating the cleaning solution holding tank of cleaning solution and for the eluent holding tank of eluent, wherein in order to improve cleaning effect
Rate, there are two the cleaning solution holding tank can be set.In addition, the groove depth of first sample holding tank 321 is set smaller than
The groove depth of two sample holding tanks 322 is for the ease of removing nucleic acid from first sample holding tank 321.Here, in order to enable
Sample container 3 or the moving displacement of nucleic acid extraction mechanism quickly and easily complete nucleic acid extraction work on the basis of minimizing
Industry, optionally, for each holding tank group, the side wall of multiple second sample holding tanks 322 is along the nucleic acid extraction
Direction Z2 is successively adjacently positioned, and the sampling hammerhead holding tank 31 and the first sample holding tank 321 are in the nucleic acid extraction
Most upstream and most downstream are spaced on multiple second sample holding tanks 322 respectively on the Z2 of direction.Here, for example, institute
Tubular structure can be formed as by stating the second sample holding tank 322, and tubular structure could be formed with conical lower portion, in order to solution
It is collected at the bottom of tubular structure, the side wall of the tubular structure of the second sample holding tank 322 is along nucleic acid extraction direction Z2 successively phase
Neighbour, accordingly, first sample holding tank 321 can also be formed to have the tubular structure of conical lower portion, so that sample holds
The overall structure of device 3 received more is rationalized, and has the effect of lightweight, saves material.But it's not limited to that for the disclosure, sample
This container 3 can be formed as the structure of other various reasonables, for example, sampling hammerhead holding tank 31, sample holding tank 32 can be with
It is machined directly to form of grooves on the ontology of sample container 3.
Optionally, for the ease of shape and be convenient for execute nucleic acid extraction operation, multiple second sample holding tanks
322 are formed as identical structure and top and bottom end are located on same plane, and the first sample accommodates in the height direction
The top of slot 321 and the top of the sampling gun holding tank 31 are lower than the top of the second sample holding tank 322.
Optionally, as depicted in figs. 1 and 2, the sample container 3 includes that can be opened and closed with the container ontology 30
The upper lid 33 of connection, the upper lid 33 include up and down and along the upper lid side wall 331 made of all around, the top
There is partition 332 along the width direction Y arranged for interval in cover side wall 331, the partition 332 is respectively along the nucleic acid extraction direction
Z2 extends, to form sampling channel 333 corresponding with each holding tank group between the every two adjacent partition 332,
Under the upper lid 33 and the lid conjunction state of the container ontology 30, the partition 332 separates every along the width direction Y
Two adjacent holding tank groups.Wherein, upper lid 33 can pass through the structures such as hinge rotationally mode and container sheet
Body 30 can be opened and closed to connect, alternatively, mode can also relatively movably can be realized by upper lid 33 and accommodating chamber ontology 30
The two can be opened and closed to connect, and the disclosure is not particularly limited this, as long as can be realized so that upper lid 33 is from container ontology
30 open or cover conjunction to the function on Rong Anqi ontology 30.By structure as described above, in upper lid 33 and container
Under the lid conjunction state of ontology 30, the bottom of each partition 332 is respectively correspondingly located between two adjacent holding tank groups, thus
Y separates every two adjacent holding tank group in the width direction, and nucleic acid extraction mechanism can make each during nucleic acid extraction
Sampling hammerhead be placed in always it is corresponding sampling channel 333 in without departing from sampling channel 333 it is mutually isolated in the state of
Nucleic acid extraction operation is executed, thus effectively avoid that cross-contamination phenomena occurs between the sample in each holding tank group, it is reliable to protect
Demonstrate,prove the quality of nucleic acid extraction.
Optionally, as shown in fig. 7, the upper lid 33 is corresponding on the position of each sampling hammerhead holding tank 31 points
It is not provided with the sampling hammerhead guide groove 334 being connected to the sampling hammerhead holding tank 31, the sampling hammerhead guide groove 334
Bottom end can respectively accordingly be engaged by clamping with the top of the sampling hammerhead holding tank 31.As a result, in sampling hammerhead guide groove
334 and sampling hammerhead holding tank 31 clamping engagement in the state of, made by the guiding of sampling hammerhead guide groove 334 and support
With so that sampling hammerhead is to be generally in vertical state in 31 inner support of sampling hammerhead holding tank, in order to execute subsequent and core
The accurate and quick assembling of sour extraction mechanism.Here, optionally, as shown in 1, Fig. 2 and Fig. 7, each sampling hammerhead guiding
Slot 334 has the connection opening 335 being connected to corresponding sampling channel 333, for passing through for sampling hammerhead 200
The connection opening 335.Wherein, the connection opening 335 can be set to be made only in the sampling hammerhead guide groove 334
Middle and upper part and do not penetrate through the sampling hammerhead holding tank 31 so that the bottom energy of sampling hammerhead guide groove 334 can be passed through
It enough plays support sampling hammerhead and is at roughly vertical state.Each sampling hammerhead holding tank 31 is loaded in nucleic acid extraction mechanism
After the sampling hammerhead in sampling hammerhead guide groove 334, because of setting for the connection opening 335 on sampling hammerhead guide groove 334
Meter, nucleic acid extraction mechanism are not necessarily to from sampling hammerhead export slot 334 exit sampling hammerhead to top completely, and only need to be by sampling gun
Head is exited from sampling hammerhead holding tank 3 to sampling hammerhead guide groove 334, is directly moved to sampling via connection opening 335
In channel 333, time and the energy needed for saving nucleic acid extraction further increase nucleic acid extraction efficiency.
In addition, in order to enable upper lid 33 reliably covers conjunction on container ontology 30, optionally, the container ontology
30 include this body sidewall 302 of horizontally disposed level board 301 and the periphery for being arranged around the level board 301, so that
The accommodating chamber ontology 30 is formed as recessed heavy formula structure, is respectively disposed on the level board 301 along perpendicular to the level board
The holding tank group for the tubulose that 301 vertical direction extends, the top of each holding tank group is from the level board 301
At least part of top of the prominent and described sample holding tank 32 is higher than described body sidewall 302.In upper lid 33 and accommodate
Under the lid conjunction state of device ontology 30, the bottom of partition 332 can be made to be inserted into the gap between adjacent holding tank group, and
So that a part on the top of every group of sample holding tank 32 is located in sampling channel 333, so that partition 332 can be in phase
The effect being effectively isolated is played between adjacent holding tank group.But it's not limited to that for the disclosure, can close according to actual needs
The arragement construction of reason ground design sample container 3.Here, optionally, protruding outward landform on the top of described body sidewall 302
At having for snapping fit onto the intracorporal anti-detachment chuck 303 of microscope carrier shell.Here, the microscope carrier is for carrying sample container 3
Carrier, that is, during nucleic acid extraction, sample container 3 can be mounted on the microscope carrier, at this point it is possible to pass through microscope carrier
Mobile or nucleic acid extraction mechanism movement successively executes the operations such as cracking, washing, elution for extracting nucleic acid, in carrier
In the case where movement, can by the clamping engagement of the anti-detachment chuck 303 that is formed on this body sidewall 302 and microscope carrier shell,
Thus microscope carrier realizes movement in the state that sample container 3 is in reliable location, thus improves the reliable of sample extraction operation
Property.But it's not limited to that for the disclosure, the sample container 3 can by other reasonably mode reliable location to microscope carrier
On, such as can be realized by way of forming positioning protrusion or positioning groove etc. on the corresponding position of sample container 3
Positioning.
According to another aspect of the present disclosure, a kind of sample processing device is provided, the sample processing device includes that nucleic acid mentions
Mechanism and sample container 3 as described above are taken, the nucleic acid extraction mechanism is movably set as, and is inserted into the sample
For extracting nucleic acid in each holding tank group of this container 3.As a result, using nucleic acid extraction mechanism in sample extraction process
In, nucleic acid extraction mechanism can first be moved to the position of the corresponding sampling hammerhead holding tank 31 of each holding tank group, so that nucleic acid
Extraction mechanism loads the sampling hammerhead being arranged in each sampling hammerhead holding tank 31 simultaneously, is moved to each holding tank group pair later
The position for the sample holding tank 32 answered and the disposable nucleic acid extraction operation for synchronously executing multiple groups, alternatively, sample can be made
Container 3 moves, while nucleic acid extraction mechanism is gone up and down in the height direction, drives it in nucleic acid extraction mechanism and fills
The sampling hammerhead of load is inserted into the corresponding sample holding tank 32 of sample container 3, thereby executing the nucleic acid extraction operation of multiple groups,
The required time of nucleic acid extraction is executed thus, it is possible to save multiple samples, and since each holding tank group contains sampling hammerhead
Holding tank 31 and can shorten nucleic acid extraction mechanism load sampling hammerhead efficiency of loading, and then effectively increase nucleic acid extraction effect
Rate.In addition, each sample is generally dispensed into the corresponding slot position of sample holding tank 32 before existing middle execution nucleic acid extraction
After interior, used dispensing sampling hammerhead is abandoned, is resulted in waste of resources, and the sample container 3 of the disclosure is due to setting
There is sampling hammerhead holding tank 31, thus used every group of dispensing can be placed into sample with sampling hammerhead after dispensing sample
In corresponding sampling hammerhead holding tank 31 of this container 3, without the dispensing is directly abandoned with sampling hammerhead
And the sample extraction sampling hammerhead for making sample extraction is recycled, thereby save sample extraction cost.
The preferred embodiment of the disclosure is described in detail in conjunction with attached drawing above, still, the disclosure is not limited to above-mentioned reality
The detail in mode is applied, in the range of the technology design of the disclosure, a variety of letters can be carried out to the technical solution of the disclosure
Monotropic type, these simple variants belong to the protection scope of the disclosure.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the disclosure to it is various can
No further explanation will be given for the combination of energy.
In addition, any combination can also be carried out between a variety of different embodiments of the disclosure, as long as it is without prejudice to originally
Disclosed thought equally should be considered as disclosure disclosure of that.
Claims (11)
1. a kind of sample container, which is characterized in that the sample container (3) includes container ontology (30), the receiving
(Y) arranged for interval has multiple holding tank groups in the width direction on device ontology (30), and each holding tank group includes mentioning along nucleic acid
Take the spaced apart sampling hammerhead holding tank (31) in direction (Z2) and sample holding tank (32).
2. sample container according to claim 1, which is characterized in that each holding tank group includes along the nucleic acid
Extract direction (Z2) the successively spaced apart one sampling hammerhead holding tank (31) and multiple described sample holding tanks (32).
3. sample container according to claim 2, which is characterized in that for the multiple described of each holding tank group
The sample holding tank for being located at most downstream on the nucleic acid extraction direction (Z2) is defined as first sample by sample holding tank (32)
Holding tank (321), by remaining sample on the nucleic acid extraction direction (Z2) in addition to the first sample holding tank (321)
Holding tank is defined as the second sample holding tank (322), the first sample holding tank (321) and the sampling hammerhead holding tank
(31) two sides of the second sample holding tank (322) are located at, the groove depth of the first sample holding tank (321) is less than institute
State the groove depth of the second sample holding tank (322).
4. sample container according to claim 3, which is characterized in that multiple described for each holding tank group
The side wall of second sample holding tank (322) is successively adjacently positioned along the nucleic acid extraction direction (Z2), and the sampling hammerhead accommodates
Slot (31) and the first sample holding tank (321) on the nucleic acid extraction direction (Z2) respectively with multiple second samples
Holding tank (322) is spaced on most upstream and most downstream.
5. sample container according to claim 4, which is characterized in that multiple second sample holding tank (322) shapes
As identical structure and top and bottom end are located on same plane, in the height direction the first sample holding tank
(321) top on top and the sampling hammerhead holding tank (31) is lower than the top of the second sample holding tank (322).
6. sample container according to any one of claims 1-5, which is characterized in that sample container (3) packet
It includes and can be opened and closed the upper lid (33) connecting with the container ontology (30), the upper lid (33) includes up and down and edge
Upper lid side wall (331) made of all around, the upper lid side wall (331) is interior to be had along the width direction (Y) arranged for interval
Partition (332), the partition (332) respectively along the nucleic acid extraction direction (Z2) extend, with it is every two adjacent it is described every
Sampling channel (333) corresponding with each holding tank group is formed between plate (332), in the upper lid (33) and the container
Under the lid conjunction state of ontology (30), the partition (332) separates the every two adjacent holding tank along the width direction (Y)
Group.
7. sample container according to claim 6, which is characterized in that the upper lid (33) corresponds to each described take
The sampling hammerhead guiding being connected to the sampling hammerhead holding tank (31) is respectively arranged on the position of sample pipette tips holding tank (31)
Slot (334), the bottom end of the sampling hammerhead guide groove (334) can respectively accordingly with the sampling hammerhead holding tank (31)
Top is engaged by clamping.
8. sample container according to claim 7, which is characterized in that each sampling hammerhead guide groove (334) tool
There is the connection opening (335) being connected to corresponding sampling channel (333), for passing through for sampling hammerhead (200)
The connection is open (335).
9. sample container described in -5 according to claim 1, which is characterized in that the container ontology (30) includes horizontal cloth
This body sidewall (302) of the level board (301) set and the periphery for being arranged around the level board (301), so that the appearance
Chamber ontology (30) of receiving is formed as recessed heavy formula structure, is respectively disposed on the level board (301) along perpendicular to the level board
(301) the holding tank group for the tubulose that vertical direction extends, the top of each holding tank group is from the level board
(301) at least part of top of the prominent and described sample holding tank (32) is higher than described body sidewall (302) on.
10. sample container according to claim 9, which is characterized in that outside on the top of described body sidewall (302)
It has been protrudedly formed for snapping fit onto the intracorporal anti-detachment chuck (303) of microscope carrier shell.
11. a kind of sample processing device, which is characterized in that the sample processing device includes nucleic acid extraction mechanism and according to right
It is required that sample container (3) described in any one of 1-10, the nucleic acid extraction mechanism is movably set as, and is inserted into
For extracting nucleic acid in each holding tank group of the sample container (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810847737.5A CN109229878A (en) | 2018-07-27 | 2018-07-27 | sample container and sample processing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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