CN109224320A - Accelerator non-coplanar radiotherapy device based on composite dual-rotating rack - Google Patents
Accelerator non-coplanar radiotherapy device based on composite dual-rotating rack Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
- A61N5/1081—Rotating beam systems with a specific mechanical construction, e.g. gantries
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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Abstract
The invention discloses an accelerator non-coplanar radiotherapy device based on a composite double-rotating frame, which comprises a main frame and a secondary frame, wherein the main frame rotates along an xz plane, the secondary frame is connected with the main frame in a rotating mode, the secondary frame rotates along a yz plane, the main frame is provided with two sets of CBCT subsystems, the two sets of CBCT subsystems are arranged in an orthogonal mode, and the secondary frame is provided with an accelerator radiation head and an EPID flat panel detector. The invention can realize multi-beam stereotactic radiotherapy, and has the advantages of simple structure, high isocenter precision, low cost, high operation efficiency and safe treatment.
Description
Technical field
The present invention relates to a kind of Medical Devices more particularly to a kind of accelerator based on Composite Double weight rotary frame are non-co-planar
Radiotherapy unit.
Background technique
Up to the present, X (γ) ray irradiation treatment technology has three big Main Achievements, is using noncoplanar irradiation as base respectively
The multi-thread beam focusing illumination technology of plinth, the intensity-modulated radiation therapy implemented by multi-leaf optical grating (Multileaf Collimator, MLC)
It (Intensity Modulated Radiation Therapy, IMRT) and establishes in KV grades of X-ray conical beam CT (Cone
Beam CT, CBCT) on the basis of image guided radiation therapy (Image Guided Radiotherapy, IGRT).
It was verified that the irradiation of non-co-planar multi-thread beam mode can actively avoid the danger closed in target area or ray path
Organ reduces human body illuminated body product and reduces its accumulated dose, therefore to improve the target dose of knurl.Due to traditional accelerator
Rotary frame can only coplanar rotation in a plane, noncoplanar irradiation is the equal centers rotation by therapeutic bed in the horizontal plane
It realizes;Clear space due to the collimator end identity distance of radiation head from isocenter point can only accomplish 400mm or so, therapeutic bed rotation
It will lead to the mutual risk of collision between radiation head and therapeutic bed or patient, and the in most cases rotation of rotary frame later
It is relatively narrow to turn range, causes many lighting dead angles, therefore the still more difficult irradiation lung cancer of traditional accelerator, liver cancer and hypophysoma etc.
The lesion at position can also cause the serious side effects of such as radiation pneumonitis.In addition, the CBCT of additional installation is further limited
The rotatable range of therapeutic bed and the technical efficiency of equipment.Third, it is mobile that the bed rotary motion in therapeutic process increases target area
Risk.
Accelerator X-radiation source is used to realize the product of truly non-co-planar multi-thread beam irradiation for U.S. An Kerui
(Accuray) Vero of the ejected wave knife (CyberKnife) of company's production and Mitsubishi Heavy Ind. Ltd.'s production.
The radiation from machine head of ejected wave knife is carried by six-DOF robot, nominal Source Axis Distance (Source to Axial
Distance, SAD) SAD=800mm, for non-co-planar more positioned ways irradiations.The shortcoming of the product, first is that kV grades of X-rays
Image is static X-ray image, verifies device (Electronic without CBCT function and without MV grades of X-ray electron images
Portal Imaging Device,EPID);Second is that not can be carried out rotation arcing irradiation;Third is that being carried using articulated robot
Accelerator increases the difficulty of robotic arm path planning during Inverse Planning, to increase radiotherapy treatment planning system
Therefore the development cost of (Radiation Therapy Treatment Planning System, TPS) simultaneously leads to product price
At 8,000,000 dollars or so.
Vero uses aperture formula structure, and O-ring type rack makees ± 180 ° of rotations under driving of cranking arm, and realizes traditional accelerator
360 ° of coplanar rotation functions of rack, on this basis, increase ring gantry in the horizontal plane, relative to therapeutic bed x-axis
± 60 ° of rotation functions realize noncoplanar irradiation, SAD=1000mm;The MLC blade of 30 couples of fineness 5mm is in equal central planes shape
At 150mm × 150mm irradiation field.Due to needing can to hold without ± 60 ° of angles are interferingly formed between ring gantry and therapeutic bed
The ring gantry aperture for carrying radiation from machine head is bound to larger, causes that slight flexure can be generated in certain angle radiation heads, in order to
This flexure is compensated, using can revolve in ring gantry annular direction and perpendicular to the axis direction of ring gantry plane
Turn ± 2.5 ° of universal head section mechanism to aim at isocenter point, therefore cause the product structure complicated, in turn results in manufacturing cost
It is higher and to eventually lead to price higher, in addition bellmouth collimator is not provided.
Summary of the invention
The present invention is intended to provide a kind of non-co-planar radiotherapy unit of accelerator based on Composite Double weight rotary frame, it can be real
Existing multi-thread beam stereotactic radiotherapy and stereotaxic radiosurgery, it is simple for structure, etc. centers precision is high, cost is relatively low, fortune
Capable efficient, treatment safety.
In order to achieve the above objectives, realization that the present invention adopts the following technical solutions:
The non-co-planar radiotherapy unit of accelerator based on Composite Double weight rotary frame of the invention, including turn along xz plane
The secondary rack of dynamic mainframe and mainframe rotation connection, the secondary rack carry two along yz Plane Rotation, the mainframe
CBCT subsystem, two sets of CBCT subsystem quadrature arrangements are covered, secondary rack carries radiation from machine head and EPID flat panel detector.
It further, further include stand, the mainframe is annulus plate-like mainframe, and the secondary rack is bicyclic rectangle
Rack, the annulus plate-like mainframe and stand are rotatablely connected, the bicyclic rectangle time two annulus of rack and two connecting levers, and two
A annulus face is simultaneously vertically arranged, and annulus plate-like mainframe connects two rack support frames, and two annulus are secondary with two respectively
The rotation connection of rack support frame, two time rack support frames and annulus plate-like mainframe are connected, the rotational plane of two annulus with
The rotational plane of annulus plate-like mainframe is vertical, and the upper end of two annulus is separately connected the lower end of two connecting levers, two connecting levers
Radiation from machine head, the EPID flat panel detector and radiation from machine head face, EPID flat panel detector are connected between upper end
It is connect with bicyclic rectangle time rack, EPID flat panel detector is lower than the bottom of annulus.
Preferably, two sets of CBCT subsystems include the first CBCT bulb between two connecting levers and two annulus,
One CBCT flat panel detector, the 2nd CBCT bulb, the 2nd CBCT flat panel detector, the first CBCT bulb, the first CBCT are flat
Partitioned detector, the 2nd CBCT bulb, the 2nd CBCT flat panel detector are all connected with annulus plate-like mainframe, the first CBCT plate
Detector and the first CBCT bulb face, the 2nd CBCT flat panel detector and the 2nd CBCT bulb face;Described first
CBCT flat panel detector, the 2nd CBCT flat panel detector relative tilt arrangement, the first CBCT bulb, the 2nd CBCT bulb position
In the top of the first CBCT flat panel detector, the 2nd CBCT flat panel detector.
Preferably, the first CBCT bulb, the 2nd CBCT bulb are higher than the center of circle of annulus, and the first CBCT plate is visited
Survey device, the 2nd CBCT flat panel detector is lower than the center of circle of annulus.
Preferably, the first CBCT bulb, the 2nd CBCT bulb pass through the first bulb support arm, the second bulb support arm respectively
Annulus plate-like mainframe is connected, the first bulb support arm, the second bulb support arm are step type.
Further, the bicyclic rectangle time rack is equipped with moveable counter weight, the first CBCT flat panel detector, second
CBCT flat panel detector passes through simple joint rotating mechanical arm connecting support arm respectively, and the support arm connects annulus plate-like mainframe.
Preferably, the appearance of the radiation from machine head is flat column, the plug-in bellmouth collimator of radiation from machine head.
Preferably, the EPID flat panel detector is mounted on the top of support frame, and the both ends of support frame as described above pass through L respectively
Plate connects the bottom of two annulus, and the moveable counter weight is flexibly connected with support frame, and support frame includes rectangle frame, the rectangle
Frame is located at the bottom of support frame, at least one side of rectangle frame is opened wide, and the moveable counter weight is located in rectangle frame.
It further, further include accelerator control system, the moveable counter weight is controlled by accelerator control system, described
Accelerator control system solidifies removable the matching for having CBCT subsystem, radiation from machine head and EPID flat panel detector assembled state
The position of weight.
Preferably, the annulus connects time rack support frame by circular ring type swivel bearing.
Specifically, the framework for support of radiation from machine head is not the coplanar rotation of single shaft of traditional accelerator in above scheme
Rack, but it is a kind of by the compound compound twin shaft rotary frame constituted of primary and secondary rack, it realizes coplanar and non-coplanar compound dual
Rotation;One respin of the compound twin shaft rotary frame switchs to annulus plate-like mainframe and makees ± 180 ° of rotations in xz plane around y-axis
Turn, realizes 360 ° of coplanar rotations;The compound double bicyclic rectangle time rack that rotates to be makees ± 45 ° of rotations around x-axis in yz plane
Turn, realizes non-co-planar multi-thread beam irradiation;Secondary gantry rotation plane is mutually perpendicular to mainframe Plane of rotation, secondary rack rotary shaft x
Axis and mainframe rotary shaft y-axis such as are respectively positioned at the central horizontals face and mutually orthogonal, and intersection point is that isocenter point (is set according to accelerator
Standby convention, isocenter point is three-dimensional coordinate origin).
The Composite Double weight rotary frame is by bicyclic rectangle time rack via secondary rack support frame, secondary rack support frame and circle
The ring disk shape mainframe composite joint is constituted;The mass center of annulus plate-like mainframe itself is located in y-axis, annulus plate-like mainframe and vertical
Frame makees circular ring type rotation connection, and rotary shaft is y-axis, and two sets of orthogonal CBCT are symmetrically mounted on the annulus plate-like host of yz plane two sides
On frame, the outside that two pieces rack support frames are mounted on CBCT system symmetrical parallelly is symmetrical about x/y plane and yz plane,
Before composite joint time rack, the mass center of annulus plate-like mainframe is located in yz plane, in the rotation of annulus plate-like mainframe, leads to
It crosses appropriate counterweight mass center is placed in y-axis;Secondary rack pass through time rack rotating arm, secondary rack rotating arm respectively with secondary rack
Support frame, secondary rack support frame make the connection of circular ring type swivel bearing, and rotary shaft is x-axis, the center of gravity of all components in secondary rack
It is symmetrical about xz plane and yz plane, in the rotation of secondary rack, mass center is placed in by isocenter point by appropriate counterweight.
Composite rotating connection between the primary and secondary rack, connects using about the symmetrical circular ring type swivel bearing of yz plane
It connects, due to the high-precision of swivel bearing, keeps the automatic realization of composite rotating connection symmetrical about x/y plane and xz plane;In circle ring disk
On shape mainframe and time rack rotating arm, respectively secondary rack support frame and radiation from machine head support, EPID and counterweight
Support frame shop bolt is set, it is possible to reduce or even exempt time rack in the equal centers debugging at user scene;Circular ring type is compound
Rotation connection does not influence operator and puts position laser in therapeutic bed two sides observation both walls when patient's lesion is located at isocenter point
Line is overlapped with what patient body-surface marked.
The appearance of the radiation from machine head 4 is flat column, is made in the edge limits position of secondary rack ± 45 °, in master
All 360 ° of rotating ranges of rack, the peace for the possible cylinder of any collision of release for wrapping up a diameter 800mm around y-axis
Full clear space;All microwave devices, including magnetron, flexible waveguide, directional coupler, four ends are also integrated with inside radiation head
Circulator, phase detector, water load and cooling water pipe;Center of gravity inside radiation from machine head is optimized for about xz plane and yz
Plane is symmetrical.
The bulb support arm and be stairstepping, ladder is located at ± 45 ° of planes of the two quadrant on annulus plate-like mainframe,
It gets out of a predicament or an embarrassing situation close to equal centers side, is vertically mounted on annulus plate-like mainframe, with bowel frequency rack 3 to when+45 ° of rotations, bulb
Support arm will not be interfered with radiation from machine head support;The separate equal centers of top bar, bulb are mounted on the peace in top bar
It fills on end face, guarantees x-ray bulb focal length isocenter point 1000mm, i.e., the focal axis of bulb is away from (Focal to Axial
Distance) FAD=1000mm, at this time at a distance of about 1400mm between two bulb focuses;Bulb end face is also equipped in top bar
Regulating mechanism and filter line device component.
The flat panel detector support arm is linear arm, and linear arm is vertically mounted on annulus plate-like mainframe, and end is single
Joint rotating mechanical arm has the installation end face parallel with linear arm, and flat bracket is mounted on installation end face, flat panel detector
It is mounted on flat bracket;Two flat panel detectors can rotating around 180 ° of axial direction opposite direction rotating of plate support arm, even if
It is still symmetrical about yz plane in plate rotary course;When CBCT system makees image guidance, flat panel detector is in close
The position of isocenter point, detector element do not have in CBCT towards bulb focus or stand-by state, flat panel detector are in separate
The position of isocenter point, plate back side cover copper sheet, guarantee the scattered rays of sigmatron when accelerator therapy to detection
The damage of device element is minimum, extends the service life of flat panel detector.The centers about 540mm, i.e. source image such as flat panel detector distance
Away from SID (Source to Image Distance) about 1540mm, SID is bigger, and image is more clear.
The EPID flat panel detector can move up and down along beam direction, rise when use and fall when not used;Flat
At the top of plate setting in the y-direction can symmetrical parallel mobile folding rolled lead, separately expose plate when plate rises and uses, flat
Plate, which is fallen to close when not used, covers plate, keeps the sigmatron through human body minimum to the damage of detector element, and do not change
Partitioned detector flatten about the symmetrical characteristic of xz plane.
Counterweight includes fixed position part and position adjustable part, itself is symmetrical about xz plane and yz plane, has foot
Enough resolution ratio moves up and down adjusting along beam direction, and accelerator control system can identify that institute is stateful, and automatically control and match
It is moved to required position again;The state of radiation from machine head is 2 kinds, and bellmouth collimator is only used with MLC or simultaneously;EPID is flat
The state of partitioned detector is 2 kinds, falls and does not have to or rise use;The state of CBCT flat panel detector has 2 kinds, faces bulb use
Or do not have to facing away from bulb;Secondary gantry rotation angle position is accurate to 1 °, there is 91 positions;Compound rack rotation has 2 kinds of states, main
Rack rotation or the rotation of secondary rack;Accelerator control system precalculates and stores the position of counterweight under all assembled states, and
Automatic driving counterweight is in place.
Up to the present, it has been applied in the accelerator treatment device of medicinal, there are no any products to have
The ability that radiation head rotates around x axis, therefore all TPS to emerge do not have the illuminating method of the secondary rack rotation yet;It is above-mentioned
TPS in scheme is characterized in that the function of rotating in addition to having more conventional frame around y-axis is also equipped with what time rack rotated around x axis
Function;Have the Reconstruction of The Function of the tangent plane picture under any noncoplanar irradiation mode, the digital reconstruction shadow in any beam direction
As (Digitally Reconstructed Radiograph, DRR) function, the launched field direction view in any beam direction
(beams eye view, BEV) function.
Beneficial effects of the present invention are as follows:
(1) the rotation connection of primary and secondary rack is all made of circular ring type rotation connection, convenient to use swivel bearing during fabrication,
And the balance of swivel bearing requires that mass center is only needed to be located at any point on rotation axis, axially and radially carries with very high
Lotus ability only needs to overcome the frictional force of very little can easily drive in balance, and swivel bearing itself has micron order
Very high degree of precision, be easy to guarantee that the precision of the isocenter point of accelerator therapy device is maintained at submillimeter level or more.
(2) Composite Double simple for structure weight rotary frame, due to having precision height and the lower advantage of manufacturing cost,
Market popularization value with higher.
(3) primary and secondary rack composite rotating radiation modality is substantially that the mainframe rotation after determining time frame angle is shone
It penetrates, the Inverse Planning process of either TPS or true therapeutic process, all embodies that process is simple, operation is efficient special
Point.
(4) rotary motion of therapeutic bed is eliminated, in addition 800mm diameter safely rotates clear space, eliminates and treated
Therapeutic bed rotary motion bring patient shifts risk and corresponding radiation head risk of collision in journey, improves the peace for the treatment of
Quan Xing also facilitates the use of the treatment auxiliary device such as respiration gate control.
(5) due to truly realizing outside non-co-planar stereotactic radiotherapy and non-co-planar stereo directional radiative
The radiation modality of section, the radiotherapy that can significantly improve the more difficult irradiated lesion of traditional accelerator such as lung cancer, liver cancer and hypophysoma are treated
Effect reduces the probability of happening for even preventing radiation pneumonitis in radiotherapy of lung cancer.
Detailed description of the invention
Fig. 1 is agent structure schematic diagram of the invention;
Fig. 2 is the embodiment front-view schematic diagram that primary and secondary rack construction is laid out for the moment;
Fig. 3 is embodiment radiation head right side view scale diagrams for the moment;
The front-view schematic diagram of primary and secondary rack construction layout when Fig. 4 is embodiment two;
Radiation head right side view scale diagrams when Fig. 5 is embodiment two;
In figure: 1: stand;2: annulus plate-like mainframe;2-1: secondary rack support frame 1;2-2: secondary rack support frame 2;2-3:
The bulb and support arm of CBCT1;The flat panel detector and support arm of 2-4:CBCT1;The bulb and support arm of 2-5:CBCT2;2-6:CBCT2
Flat panel detector and support arm;3: secondary rack;3-1: secondary rack rotating arm 1;3-2: secondary rack rotating arm 2;3-3: accelerate
Device radiates head support;The support frame of 3-4:EPID flat panel detector and counterweight;3-5: counterweight;4: radiation from machine head;4-1:
EPID flat panel detector and bracket;4-2: accelerating tube;4-3: example of primary collimator;4-4: expansion filter;4-5: ionisation chamber: 4-6:
Launched field lamp reflector;The direction 4-7:y tungsten door;The direction 4-8:x tungsten door;The direction 4-9:x MLC;4-10: bellmouth collimator and installation
Bracket;5: therapeutic bed;5-1: treatment bed surface;5-2: treatment bed surface end counterweight.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with attached drawing, to the present invention into
Row is further described.
Embodiment one
Accelerator non-co-planar radiotherapy unit of the present invention based on Composite Double weight rotary frame, comprising: stand
1, annulus plate-like mainframe 2, the bulb of the bulb of CBCT1 and the flat panel detector of support arm 2-3, CBCT1 and support arm 2-4, CBCT2
With the flat panel detector and support arm 2-6, secondary rack support frame 2-1, secondary rack support frame 2-2 of support arm 2-5, CBCT2, bicyclic rectangle
Secondary rack 3 (including secondary rack rotating arm 3-1, secondary rack rotating arm 3-2, radiation from machine head support 3-3, EPID are flat
The support frame 3-4 of partitioned detector and counterweight), radiation from machine head 4, EPID flat panel detector and bracket 4-1, counterweight 3-5, taper
Hole collimator 4-10, therapeutic bed 5 and TPS (not marked in figure).
The rotation connection of primary and secondary rack is all made of swivel bearing, and bearing outside is fastened on fixed frame, and inner sleeve then fastens one
Ring-like short tube, ring-like short tube are fastened on rotating part again;For mainframe, fixed frame is that the band being fixed on pre-buried pedestal adds
The fixation stand 1 of strengthening tendons, rotating part are annulus plate-like mainframe 2;For secondary rack 3, fixed frame is time rack support frame 2-1
And 2-2, rotating part are two rotating arms 3-1 and 3-2.There are a circle gear teeth in ring-like short tube outer ring, is used as the chaindriven tooth of tooth,
Metal bracelet is hung over and is driven on tooth.Bidirectional rotation DC servo electricity of the driving motor with reduction gearbox and brake apparatus
Machine, the driving motor of mainframe are horizontally arranged on the bottom plate of the subsequent stand 1 of lower right corner square hole in figure, and motor shaft is from rectangular
Hole is stretched out, and is equipped with carousel gear on axis, chain covers on gear, and motor bidirectional rotation is to drive mainframe bidirectional rotation;?
Appropriate location in stand is also equipped with tensioning wheel.The driving method of secondary rack rotating arm is identical, is driven with bi-motor is synchronous
Two rotating arms 3-1 and 3-2, motor are mounted on annulus plate-like mainframe 2, the axis of two motors respectively to the left, it is vertical to the right
It is parallel with time rack support frame plane in the gear in the plane of secondary rack support frame 2-1 and 2-2, motor shaft.Secondary rack support
Square hole on frame 2-1 and 2-2 is for facilitating passing through for various cables, cooling water pipe and sulfur hexafluoride tracheae.In manufacturing process,
Swivel bearing uses permanent assembly method, i.e., annulus plate-like mainframe 2 is assembled in stand 1 in advance in the factory, as one
A global facility packed and transported is sent to user scene;The rotating arm 3-1 and 3-2 of secondary rack are respectively assembled to time rack support
On frame 2-1 and 2-2, user scene is sent to respectively as global facility packed and transported.
According to accelerator facility convention, when directions of rays along z-axis vertically downward when, for 0 ° of position of coplanar rotation mainframe
It sets, the definition of mainframe rotation angle is to clockwise turn to 0 °~+180 °, rotates to be 0 °~-180 ° counterclockwise, mainframe can
It is rotated by 360 ° from -180 ° to+180 ° only, vice versa;In the present invention, if when directions of rays along z-axis vertically downward when, be secondary
0 ° of position of rack, corner when secondary rack is rotated to mainframe direction are positive, and secondary rack far from mainframe direction to when rotating
Corner be negative, the rotating range of secondary rack is ± 45 °.
The Source Axis Distance SAD=1000mm that the present embodiment uses conventional accelerator to generally use, and guarantee to rotate in secondary rack
When to ± 45 ° of extreme positions, no matter vertical range of the lower edge of radiation from machine head apart from y-axis is greater than or equal to 400mm, i.e.,
Primary and secondary rack is in any position, between the cylindrical safe clearance that all there is a diameter 800mm along y-axis.
In conjunction with shown in Fig. 2 and Fig. 3, it is formed installation site, the CBCT detection of CBCT bulb support arm 2-3 and 2-5 at this time
The installation site of device plate support arm 2-4 and 2-6, the installation site of secondary rack support frame 2-1 and 2-2 and its be mounted on mainframe connects
The length of contacting surface, the length of secondary rack rotating arm 3-1 and 3-2, the height of isocenter point, isocenter point leave annulus plate-like master
The distance of rack 2, the height of radiation from machine head 4, the width of radiation head 4, the shape of radiation head 4, length of accelerating tube etc. because
The constraint of element.
The confinement dimension of the present embodiment primary Calculation is as follows, but is not limited to more preferably size.
The diameter 2400mm of annulus plate-like mainframe 2, the diameter of a circle 800mm that center is clipped, is exactly equal to safety cylinder
The diameter of shape clear space facilitates the anti-bump sensor of circular ring type of installation diameter 800mm, such as infrared transmitting receiver;Various electricity
Cable, cooling water pipe and sulfur hexafluoride tracheae can be from fixed stand sides, and the appropriate location through mainframe annulus inside edge is worn
Mainframe is more arrived, the respective target position gone then is arranged into.The height 1350mm of isocenter point, isocenter point is apart from host
Frame 1050mm.
CBCT system be located at it is mutually orthogonal on ± 45 ° of lines of mainframe two sides, the center of the installation site of bulb support arm away from
Vertical range about 600mm from isocenter point, the centre distance isocenter point of the installation site of flat panel detector support arm it is vertical
Distance about 635mm.Bulb support arm is stairstepping, and ladder is located at ± 45 ° of planes of a two quadrant on annulus plate-like mainframe 2, under
Step is vertically mounted on annulus plate-like mainframe 2 close to equal centers side, with bowel frequency rack 3 to when+45 ° of rotations, bulb branch
Arm 2-3 and 2-5 will not be interfered with radiation from machine head support 3-3;The separate equal centers of top bar, bulb, which is mounted on, appears on the stage
On installation end face on rank, guarantee x-ray bulb focal length isocenter point 1000mm, i.e., the focal axis of bulb is away from (Focal to
Axial Distance) FAD=1000mm, at this time at a distance of about 1400mm between two bulb focuses;Ball is also equipped in top bar
End surfaces regulating mechanism and filter line device component.
Flat panel detector support arm 2-4 and 2-6 are linear arm, and linear arm is vertically mounted on annulus plate-like mainframe 2, end
For simple joint rotating mechanical arm and have the installation end face parallel with linear arm, flat bracket is mounted on installation end face, plate
Detector is mounted on flat bracket;Two flat panel detectors can be rotating around the axial direction opposite direction rotating of plate support arm
180 °, even if in plate rotary course, it is still symmetrical about yz plane;When CBCT system makees image guidance, plate detection
Device is in close to the position of isocenter point, and detector element does not have in CBCT towards bulb focus or stand-by state, plate detect
Device is in the position far from isocenter point, and plate back side covers copper sheet, guarantees dissipating for sigmatron when accelerator therapy
Ray is minimum to the damage of detector element, extends the service life of flat panel detector.The centers such as flat panel detector distance are about
540mm, i.e. source image are away from SID (Source to Image Distance) about 1540mm, and SID is bigger, and image is more clear.
Secondary rack support frame 2-1 and 2-2 parallel installation and all symmetrical up and down vertically, their peaces on mainframe 2
It fills end face length and is greater than 1000mm, mutual distance about 1600mm;Secondary rack rotating arm 3-1 and 3-2 are mounted on time rack support
The outside of frame, so that various cables, cooling water pipe and sulfur hexafluoride tracheae are arranged into everywhere along time rack rotating arm.
Secondary rack rotating arm 3-1 and 3-2 are about 1800mm, and support frame 3-3 and 3-4 makees rescinded angle processing in both ends, so as to every
When a angle rotates to bottom, still there is the safety clearance of about 50mm apart from ground;Meanwhile the top of radiation from machine head 4 is also
Identical purpose makees rescinded angle processing.
EPID flat panel detector 4-1 can move up and down along beam direction, rise when use and fall when not used;In plate
The rolled lead that can move in parallel folding in the y-direction is arranged in top, separately exposes plate when plate rises and uses, falls in plate
It closes when not used and covers plate, keep the sigmatron through human body minimum to the damage of detector element, and do not change plate
Detector is about the symmetrical characteristic of yz plane.
Counterweight 3-5 includes fixed part and can move up and down part along beam direction, and balance mechanism is: counterweight 3-
5 itself is symmetrical about xz plane and yz plane, and there is movable part enough resolution ratio to move up and down adjusting along beam direction;
When bicyclic rectangle time rack 3 rotates, no matter EPID flat panel detector, which is in, rises using or falls unused position, and movement is matched
The mass center of secondary rack 3 is placed in isocenter point again;When annulus plate-like mainframe 2 rotates, since the center of gravity of yz plane two sides is eternal
Symmetrically, accelerator control system precalculates and stores the position of counterweight 3-5 under all assembled states, and drives counterweight 3- automatically
5 in place, and the mass center of compound rack is placed in y-axis.
Radiation from machine head height about 650mm, the direction x length 600mm, this size need maximum that can increase according to specific design
It is added to 700mm or so;At this point, in the case where meeting all collimator assembly height 80mm, on radiation head inside center line, on to
Under successively install: accelerating tube 4-2, the example of primary collimator 4-3 of 80mm high, ionisation chamber 4-5, the direction the y tungsten door of 80mm high are (secondary quasi-
Straight device) 4-7, the direction the x tungsten door 4-8 of 80mm high, 80mm high the direction x MLC 4-9.When actual design, the direction x tungsten door 4-8's
Height only needs 20mm, and the remaining space 60mm can meet the needs of selectivity installation expansion filter and launched field lamp reflector,
Meanwhile it can also suitably mitigate the total quality of radiation from machine head.Tungsten door is double focusing mode, i.e., tungsten door tracks are ring
Type, in different irradiation fields, tungsten door end face is parallel with beam.In addition to this, all microwaves are also integrated with inside radiation head
Device, including magnetron, flexible waveguide, directional coupler, four-pole circulator, phase detector, water load and cooling water pipe;Add
Center of gravity inside fast device radiation head 4 is optimized for symmetrical about xz plane and yz plane.Accelerating tube length is limited in the present embodiment
Within 300mm, therefore C-band accelerating tube is used, 6MeV monoergic X-radiation radiotherapy is provided.To prevent radiation from machine head
It bends, support frame is integrated with the mounting rack in reinforcing rib and support frame body frame and radiation head and is located at radiation
Head centroidal planes.
Width about 360mm of the radiation from machine head 4 in the direction y, top and bottom symmetrical rescinded angle, rescinded angle at 100mm
Top width afterwards is 200mm, bottom width 140mm.Irradiation field the direction y size by the direction y tungsten door opening degree and
The MLC blade quantity moved in the x-direction determines;The upper edge of MLC is about 250mm apart from radiation source, therefore amplification ratio is 4, i.e.,
The width of MLC blade is 4 times of its physical width on equal central planes;It uses physical width for the MLC blade of 1.5mm, is waiting
Width on central plane is 6mm;50 pairs of MLC blades are installed, physical width 75mm can be obtained in equal central planes
The irradiation field of 300mm.Irradiation field the direction x size by the direction x tungsten door opening degree and in the x-direction the MLC blade that moves can
It is determined with the length of free movement;Although length of the radiation head in the direction x is 600mm to 700mm, in view of MLC blade
Center line demand is crossed, the irradiation field size by irradiation field in the direction x is limited to 300mm.MLC is monofocal mode, i.e. MLC movement
Track is linear type, and MLC vane end faces are circular arc type.The present embodiment can realize 300mm × 300mm size in equal central planes
Irradiation field, the fine degree of MLC blade is 6mm.
The width for the treatment of bed surface 5-1 is 520mm, and the movable maximum magnitude in left and right is ± 140mm, when additional human body thickness
When 100mm, therapeutic bed declines 100mm, and side-to-side movement range is ± 120mm;The minimum altitude that treatment bed surface is liftoff about 700mm,
Dedicated ladder, which is configured, in the side for the treatment of bed body facilitates patient or more therapeutic bed, it, will not due to eliminating therapeutic bed rotation demand
Influence the technical efficiency of equipment.
Since the rotary shaft of secondary rack was the x-axis of isocenter point, because this rack occupies the centers such as therapeutic bed two sides
Patient's lesion is put position to isocenter point in order to facilitate the operation of member, added in therapeutic room's both walls with roof by neighbouring space
A set of pendulum position laser lamp, the plane of three laser lamps are translated to therapeutic bed bed body direction to avoid the position that time rack occupies, shape
At virtual isocenter point O1=(x1,y1,z1), the positional relationship with true isocenter point O=(0,0,0) is x-x1=0, y-y1
=constant, z-z1=constant;An automatic in-position button is designed by therapeutic bed, after completing virtual isocenter point pendulum position, is only needed
Automatic in-position button is clicked, therapeutic bed is automatically moved to true isocenter point by rising to translate forward with panel, operates
On the outside of member station to time rack rotating ring, observes again and confirm being overlapped for pendulum position laser rays and patient body-surface mark line.Machine
The pendulum position of two dimension water tank also uses this method when the pendulum position of equivalent Water ball and machine data acquire when Dose Calibration.
Embodiment two
As shown in Figure 1, Figure 4 and Figure 5, in the present embodiment, using SAD=1200mm, accelerating length of tube is still 300mm, spoke
Penetrating width of the head in the direction y is still 360mm, is different from embodiment one, and radiation from machine head does not have the truncated portion of lower end 100mm
Point, but replaced with dismountable bellmouth collimator 4-10;At this point, radiation from machine grease head highness 750mm, etc. centre-heights
1550mm, etc. centre distances mainframe distance 1200mm.
Installation end face length of the secondary rack support frame 2-1 and 2-2 on mainframe 2 is greater than 1100mm, and mutual distance is still
1600mm;The length of secondary rack rotating arm 3-1 and 3-2 increase to about 2000mm.All support arms of CBCT system are in circle ring disk
Installation site and mode on shape mainframe 2 are the same as example 1.
In the case where meeting all collimator assembly height 80mm, on radiation head inside center line, successively install from top to bottom:
Accelerating tube 4-2, example of primary collimator 4-3, expansion filter 4-4, ionisation chamber 4-5, the direction launched field lamp reflector 4-6, y tungsten door 4-7,
The direction the x direction tungsten door 4-8, x MLC 4-9.The bellmouth collimator mounting bracket of radiation head lower end mounting height 30mm, height
The detachable bellmouth collimator 4-10 of 100mm is mounted on bracket.It is the same as example 1, when actual design, the direction x tungsten door
Height is 20mm.
Distance of the upper edge of MLC blade apart from radiation source is about 360mm, amplification ratio about 3.333, using physical width
The MLC blade of 1.5mm, then MLC blade is 5mm in the projection width of equal central planes, and 50 MLC blades are in y-axis direction etc.
The radiation field size of heart plane is 250mm.Therefore, the present embodiment can be in the irradiation of equal central planes realization 250mm × 250mm size
Open country, the fine degree of MLC blade are 5mm.Distance of the bellmouth collimator 4-10 apart from radiation source is about 480mm, amplification ratio
It is 2.5, when diametrically accomplishing 1.2mm on bellmouth, can get diameter in equal central planesRound irradiation field,
Therefore bellmouth collimator is waiting the size of central planes to use diameter Deng
Size, for carrying out non-co-planar Stereotactic Radiosurgery.
Implementation process of the present invention embodies, and by cylindric radiation head used by conventional accelerator, changes into the flat of rectangle
Flat column radiation head also makes the present invention more beautiful in appearance.Above-mentioned implementation process also embodies: the target to accelerate pipe end
Window is boundary, and radiation from machine head can be divide into upper part and lower part;The centre-heights such as the length restriction of upper part accelerating tube, and change etc.
Centre-height can choose the length of accelerating tube, if in example 1 by etc. centre-heights change into 1400mm, can be with
Using length in the accelerating tube of 350mm, i.e. S-band accelerating tube, and S-band accelerating tube is most mature and inexpensive accelerating tube, this
Keep the selection of accelerating tube more flexible;If in embodiment two use length 250mm X-band accelerating tube, etc. centre-heights
1500mm can be reduced to;According to the inverse square law of radiation field intensity, the central planes irradiation field such as when SAD=1200mm
1/1.44th when intensity is SAD=1000mm, i.e., 69.44%, the dosage rate of modern accelerators can achieve it is very high, and
The accumulated dose that the present invention treats every time will share tens of or even hundreds of noncoplanar irradiations open countries, and SAD will not influence after extending to be added
The technical efficiency of fast device, and big Source Axis Distance leads to big ource-skin Distance, advantageously reduces the field dose of human skin.Implement
Example second is that the preferred embodiments of the invention, have benefited from the extensive non-co-planar coverage area along 2 π spherical angle of trunk direction,
Non-co-planar stereotaxis based on 5mm fineness MLC rotates intensity-modulated radiation therapy, it is contemplated that can significantly improve the bodies such as lung cancer and liver cancer
The radiotherapy effect of the more difficult irradiated lesion in portion, and it is effectively reduced or prevents the probability of happening of radiation pneumonitis;Based on diameter
Strong radiosurgery is adjusted in the non-co-planar stereotaxis rotation of the serial bellmouth collimator risen, it is contemplated that can significantly improve hypophysoma
The radiotherapy effect of the equal more difficult irradiated lesion in heads.
Certainly, the present invention can also have other various embodiments, without deviating from the spirit and substance of the present invention, ripe
Various corresponding changes and modifications, but these corresponding changes and modifications can be made according to the present invention by knowing those skilled in the art
All it should fall within the scope of protection of the appended claims of the present invention.
Claims (10)
1. a kind of non-co-planar radiotherapy unit of accelerator based on Composite Double weight rotary frame, it is characterised in that: including along xz
The mainframe of Plane Rotation, the secondary rack with mainframe rotation connection, the secondary rack are held along yz Plane Rotation, the mainframe
Two sets of CBCT subsystems, two sets of CBCT subsystem quadrature arrangements are loaded with, secondary rack carries radiation from machine head and EPID plate
Detector.
2. a kind of non-co-planar radiotherapy unit of accelerator based on Composite Double weight rotary frame, it is characterised in that: further include standing
Frame, the mainframe are annulus plate-like mainframe, and the secondary rack is bicyclic rectangle time rack, the annulus plate-like mainframe with
Stand rotation connection, the bicyclic rectangle time two annulus of rack and two connecting levers, two annulus faces are simultaneously vertically arranged, annulus
Plate-like mainframe connects two rack support frames, and two annulus are rotatablely connected with two rack support frames respectively, and two times
Rack support frame and annulus plate-like mainframe are connected, and the rotational plane of two annulus and the rotational plane of annulus plate-like mainframe hang down
Directly, the upper end of two annulus is separately connected the lower end of two connecting levers, connects radiation from machine head, institute between the upper end of two connecting levers
EPID flat panel detector and radiation from machine head face are stated, EPID flat panel detector is connect with bicyclic rectangle time rack, and EPID is flat
Partitioned detector is lower than the bottom of annulus.
3. the accelerator non-co-planar radiotherapy unit according to claim 2 based on Composite Double weight rotary frame, special
Sign is: two sets of CBCT subsystems include the first CBCT bulb, the first CBCT between two connecting levers and two annulus flat
Partitioned detector, the 2nd CBCT bulb, the 2nd CBCT flat panel detector, the first CBCT bulb, the first CBCT flat panel detector,
2nd CBCT bulb, the 2nd CBCT flat panel detector are all connected with annulus plate-like mainframe, the first CBCT flat panel detector with
First CBCT bulb face, the 2nd CBCT flat panel detector and the 2nd CBCT bulb face;The first CBCT plate is visited
Device, the 2nd CBCT flat panel detector relative tilt arrangement are surveyed, the first CBCT bulb, the 2nd CBCT bulb are located at the first CBCT
The top of flat panel detector, the 2nd CBCT flat panel detector.
4. the accelerator non-co-planar radiotherapy unit according to claim 3 based on Composite Double weight rotary frame, special
Sign is: the first CBCT bulb, the 2nd CBCT bulb are higher than the center of circle of annulus, the first CBCT flat panel detector, the
Two CBCT flat panel detectors are lower than the center of circle of annulus.
5. the accelerator non-co-planar radiotherapy unit according to claim 3 or 4 based on Composite Double weight rotary frame,
Be characterized in that: the first CBCT bulb, the 2nd CBCT bulb pass through the first bulb support arm, the second bulb support arm connection circle respectively
The ring disk shape mainframe, the first bulb support arm, the second bulb support arm are step type.
6. the accelerator non-co-planar radiotherapy unit according to claim 5 based on Composite Double weight rotary frame, special
Sign is: the bicyclic rectangle time rack is equipped with moveable counter weight, and the first CBCT flat panel detector, the 2nd CBCT plate are visited
It surveys device and passes through simple joint rotating mechanical arm connecting support arm respectively, the support arm connects annulus plate-like mainframe.
7. the accelerator non-co-planar radiotherapy unit according to claim 6 based on Composite Double weight rotary frame, special
Sign is: the appearance of the radiation from machine head is flat column, the plug-in bellmouth collimator of radiation from machine head.
8. the accelerator non-co-planar radiotherapy unit according to claim 6 or 7 based on Composite Double weight rotary frame,
Be characterized in that: the EPID flat panel detector is mounted on the top of support frame, and the both ends of support frame as described above pass through L plate respectively and connect
The bottom of two annulus, the moveable counter weight are flexibly connected with support frame, and support frame includes rectangle frame, and the rectangle frame is located at
At least one side of the bottom of support frame, rectangle frame is opened wide, and the moveable counter weight is located in rectangle frame.
9. the accelerator non-co-planar radiotherapy unit according to claim 8 based on Composite Double weight rotary frame, special
Sign is: further including accelerator control system, the moveable counter weight is controlled by accelerator control system, the Accelerator control
System solidifies the position for having the moveable counter weight of CBCT subsystem, radiation from machine head and EPID flat panel detector assembled state.
10. the accelerator non-co-planar radiotherapy unit according to claim 2 based on Composite Double weight rotary frame, special
Sign is: the annulus connects time rack support frame by circular ring type swivel bearing.
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WO2020082654A1 (en) * | 2018-10-23 | 2020-04-30 | 四川大学华西医院 | Composite double-rotation frame accelerator-based non-coplanar radiotherapy apparatus |
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