CN109224068B - Pharmaceutical composition for preventing and treating sheep lithangiuria and preparation method thereof - Google Patents
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Abstract
The invention provides a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep, which comprises the following components in percentage by mass: 30 to 35 percent of desmodium; 5 to 10 percent of Japanese climbing fern spore; 5 to 10 percent of plantain seed; 5-10% of fringed pink and 40-55% of glucose oxidase. According to the invention, the desmodium, the lygodium japonicum, the plantain seed, the dianthus superbus and the glucose oxidase are compounded to generate the pharmaceutical composition which has strong calculus eliminating effect and has the effects of clearing damp-heat, eliminating infection and the like; in addition, the pharmaceutical composition is prepared into tablets, capsules, granules or pills by technical methods of crushing, screening, decocting, drying and the like, and is suitable for various feeding methods.
Description
Technical Field
The invention relates to the technical field of medical medicines, in particular to a pharmaceutical composition for preventing and treating sheep lithangiuria and a preparation method thereof.
Background
The urinary tract calculus of sheep, also called urolithiasis, is a disease which is generated or remained in renal pelvis, ureter, bladder and urethra, and is caused by the salt crystallization mainly comprising calcium carbonate and phosphate, so that sheep have difficulty in micturition and urinary organs are inflamed due to calculus. After the disease occurs, the sick sheep have abnormal spirit, weak screaming voice, abdominal distension, uneasy rising and lying, two hind limbs alternately kick the hind abdomen and the arch back, and can not normally urinate or have the phenomenon of dripping urine, the position of the calculus has enhanced sensitivity, blood is in the urine, the sick sheep like lying, do not want to exercise, have tachycardia and irregular rhythm, and can quickly cause peritonitis.
At present, when fattening sheep are fed in domestic sheep farms, coarse feed and fine feed are generally mixed uniformly to be made into complete ration, the feeding mode is good in effect of feeding and breeding ewes, however, as the fine feed is mainly used in the ration of the fattening sheep, the coarse feed is used as an auxiliary feed, when the sheep flocks are too high in density and too large in quantity, the phenomenon of snatching is easily caused when the sheep flocks are not uniform in size, so that the fine feed eaten by some sheep is too much, the fine feed eaten by other fat sheep is less, the sheep flocks are not uniform in thinness after long-term use, the sheep flocks are out of the pens irregularly, and the probability that part of sheep get stones is increased. In addition, due to lack of scientific management, the ingestion of nutrients by sheep flocks is incomplete, and when the ingested calcium and phosphorus proportion is unbalanced, sheep calculus is easy to occur.
Therefore, the technical personnel in the field need to solve the problems that the pharmaceutical composition for preventing and treating sheep lithangiuria and the preparation method thereof can effectively prevent and treat the lithangiuria of fattening sheep and reduce the economic loss of the fattening sheep caused by the lithangiuria.
Disclosure of Invention
In view of the above, the invention provides a pharmaceutical composition for preventing and treating sheep lithangiuria and a preparation method thereof, which is prepared by compounding herba lysimachiae, lygodium japonicum, semen plantaginis, fringed pink and glucose oxidase, and has the effects of eliminating calculi, clearing damp-heat, eliminating infection and the like; in addition, the pharmaceutical composition is prepared into tablets, capsules, granules or pills by technical methods of crushing, screening, decocting, drying and the like, and is suitable for various feeding methods.
In order to achieve the purpose, the invention adopts the following technical scheme:
a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep comprises the following components in percentage by mass:
further, the pharmaceutical composition comprises the following components in percentage by mass:
wherein, the longhairy antenoron herb is slightly cold in nature, sweet in taste and salty in flavor; it enters liver meridian, gallbladder meridian, kidney meridian, and bladder meridian; acid-containing components, sterol, flavonoid, amino acid, tannin, volatile oil, choline, etc.; and polysaccharide, multiple trace elements, kaempferide, kaempferol-3-0-galactoside, kaempferol-3-0-nacre triglycoside, and kaempferol-3-0-glucoside. The herba Lysimachiae Christinae has effects of clearing away dampness and heat, treating stranguria, relieving swelling, promoting diuresis and eliminating jaundice, and has certain effect of inhibiting Staphylococcus aureus.
Spora Lygodii is sweet in taste and cold in nature; it enters bladder meridian and small intestine meridian; comprises water soluble aureofuscin, organic acids such as palmitic acid, stearic acid, oleic acid, linoleic acid, trans-p-coumaric acid, and myristic acid, and methyl ester of gibberellin A73; has effects of clearing away heat and dampness, relieving stranguria, relieving pain, and increasing ureteral peristalsis. In addition, it has inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa, Shigella flexneri and Salmonella typhi.
The plantain seed is sweet in flavor and cold in nature; has effects of promoting diuresis, clearing heat away, improving eyesight, and eliminating phlegm. When the plantain seed is used together with lygodium japonicum, the plantain seed can clear away heat and dampness, and lygodium japonicum can treat stranguria and pain caused by damp-heat accumulation in bladder or calculus caused by damp-heat.
The pink herb is cold in nature and bitter in taste; heart meridian and small intestine meridian entered; comprises saponin, sugar vitamin A-like substance, Haloenoside-6-cis-alpha-D-glucopyranoside, Haloenoside-6-trans-alpha-D-glucopyranoside, anethole, herba Dianthi saponin, herba Dianthi pyrone glycoside, and methyl salicylate. The herba Dianthi has effects of inducing diuresis for treating stranguria, and removing blood stasis and dredging channels, and also has inhibitory effect on Staphylococcus aureus, Escherichia coli, typhoid bacillus, Shigella flexneri, and Pseudomonas aeruginosa.
The fringed pink is compatible with lygodium japonicum, and the fringed pink has the functions of treating stranguria and inducing diuresis by virtue of the middle-small yin of yang as adjuvant; the spora lygodii is used for treating stranguria and removing calculus; the two are used together to achieve the effects of clearing heat, treating stranguria and removing calculus, and can be used for treating damp-heat stranguria or pain in the stem of stranguria caused by urinary stone, hematuria, etc.
The invention provides a pharmaceutical composition for preventing and treating sheep fattening urinary calculus, which is prepared by compounding herba lysimachiae, lygodium japonicum, semen plantaginis, dianthus superbus and glucose oxidase, has strong calculus eliminating effect and the effects of clearing damp heat, eliminating infection and the like, and not only can effectively prevent and treat sheep fattening urinary calculus, but also can effectively reduce economic loss caused by urinary calculus.
Further, the medicine is tablets, capsules, granules or pills.
The dosage form plays a key role in exerting curative effect under certain conditions, mainly shows the influence on the release and absorption of the medicament, wherein, the dosage of the tablet is accurate, the quality is stable, and certain medicaments which are easy to oxidize, deteriorate and deliquesce can be protected by coating and are convenient to carry, transport and take; the pill can slowly disintegrate in gastrointestinal tract, gradually release medicine, has lasting effect, and can delay absorption of toxic, severe and irritant medicine, and reduce toxicity and adverse reaction; the granule has rapid action, small volume, and convenient administration and storage. The pharmaceutical composition can be prepared into various pharmaceutical dosage forms for selection, and the administration mode can be adaptively selected according to the condition of fattening sheep, so that the condition of fattening sheep urinary tract calculus can be quickly relieved.
A preparation method of a pharmaceutical composition for preventing and treating sheep fattening lithangiuria comprises the following specific steps:
(1) pulverizing herba Lysimachiae Christinae, semen plantaginis and herba Dianthi, and sieving to obtain fine powder and coarse powder of each component respectively;
(2) decocting the coarse powder and spora Lygodii with rice washing water, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.50-1.52 at 50 deg.C to obtain concentrated solution;
(3) mixing the fine powder, glucose oxidase and the concentrated solution, drying, and making into tablet, capsule, granule or pill with pharmaceutically acceptable carrier.
Further, the aperture of the mesh sieve in the step (1) is 125 μm.
Further, the decocting method in the step (2) is decocting for 3 times, and each time lasts for 40-60 minutes.
The invention utilizes the medicinal value of the medicament to the maximum extent by the technical methods of crushing, screening, decocting, drying and the like, and the medicinal composition is prepared into tablets, capsules, granules or pills, and is suitable for various feeding methods.
According to the technical scheme, compared with the prior art, the preparation method of the pharmaceutical composition for preventing and treating the urinary tract stones of the fattening sheep has the following technical advantages:
the invention provides a pharmaceutical composition for preventing and treating sheep lithangiuria and a preparation method thereof, wherein lysimachia, lygodium japonicum, plantain seed, fringed pink and glucose oxidase are compounded to generate the pharmaceutical composition which has strong calculus eliminating effect and the effects of clearing damp heat, eliminating infection and the like, the curative effect is obvious, the symptom of urination pain of sick livestock is relieved after the pharmaceutical composition is used for 3-5 days, and the urination of sick sheep is recovered to be normal; in addition, the pharmaceutical composition is prepared into tablets, capsules, granules or pills by technical methods of crushing, screening, decocting, drying and the like, and is suitable for various feeding methods. The invention has the advantages of simple and convenient treatment method,
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment discloses a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep, which comprises the following components in percentage by mass: 32% of longhairy antenoron herb; 8% of spora lygodii; 7% of semen plantaginis; 8% of fringed pink and 45% of glucose oxidase.
Crushing 32g of longhairy antenoron herb, 7g of plantain seed and 8g of fringed pink, and sieving by a sieve, wherein the aperture of the sieve is 125 mu m, so as to respectively obtain fine powder and coarse powder corresponding to each component for later use; decocting the coarse powder and spora Lygodii 8g with rice washing water 300g for 45 min for 3 times, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.50 at 50 deg.C to obtain concentrated solution; mixing the fine powder, glucose oxidase 45g and the concentrated solution, drying, adding pharmaceutically acceptable carrier, and making into tablet, capsule, granule or pill.
Example 2
The embodiment discloses a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep, which comprises the following components in percentage by mass: 35% of longhairy antenoron herb; 5% of spora lygodii; 5% of plantain; 5% of fringed pink and 50% of glucose oxidase.
Pulverizing 35g of herba Lysimachiae Christinae, 5g of semen plantaginis and 5g of herba Dianthi, and sieving with a sieve having a pore size of 125 μm to obtain fine powder and coarse powder of each component respectively; decocting the coarse powder and 5g spora Lygodii with rice washing water for 40 min for 3 times, wherein the rice washing water is 300g, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.52 at 50 deg.C to obtain concentrated solution; mixing the fine powder, glucose oxidase 50g and the concentrated solution, drying, adding pharmaceutically acceptable carrier, and making into tablet, capsule, granule or pill.
Example 3
The embodiment discloses a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep, which comprises the following components in percentage by mass: 30% of longhairy antenoron herb; 10% of spora lygodii; 10% of semen plantaginis; 10% of fringed pink and 40% of glucose oxidase.
Pulverizing 30g of herba Lysimachiae Christinae, 10g of semen plantaginis and 10g of herba Dianthi, and sieving with a sieve having a pore size of 125 μm to obtain fine powder and coarse powder of each component respectively; decocting the coarse powder and spora Lygodii 10g with rice washing water 300g for 45 min for 3 times, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.50 at 50 deg.C to obtain concentrated solution; mixing the fine powder, glucose oxidase 40g and concentrated solution, drying, adding pharmaceutically acceptable vehicle, and making into tablet, capsule, granule or pill.
Example 4
The embodiment discloses a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep, which comprises the following components in percentage by mass: 30% of longhairy antenoron herb; 5% of spora lygodii; 5% of semen plantaginis; 6 percent of fringed pink and 54 percent of glucose oxidase.
Pulverizing 30g of herba Lysimachiae Christinae, 5g of semen plantaginis and 6g of herba Dianthi, and sieving with a sieve having a pore size of 125 μm to obtain fine powder and coarse powder of each component respectively; decocting the coarse powder and 5g spora Lygodii with rice washing water for 60 min for 3 times, wherein the rice washing water is 300g, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.51 at 50 deg.C to obtain concentrated solution; mixing the fine powder, 54g glucose oxidase and concentrated solution, drying, adding pharmaceutically acceptable carrier, and making into tablet, capsule, granule or pill.
Comparative example 1
The comparative example discloses a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep, which comprises the following components in percentage by mass: 28% of longhairy antenoron herb; 12% of spora lygodii; 4% of semen plantaginis; 11% of fringed pink and 45% of glucose oxidase.
Pulverizing 28g of herba Lysimachiae Christinae, 4g of semen plantaginis and 11g of herba Dianthi, and sieving with a sieve having a pore size of 125 μm to obtain fine powder and coarse powder of each component respectively; decocting the coarse powder and spora Lygodii 12g with rice washing water 300g for 45 min for 3 times, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.50 at 50 deg.C to obtain concentrated solution; mixing the fine powder, glucose oxidase 45g and the concentrated solution, drying, adding pharmaceutically acceptable carrier, and making into tablet, capsule, granule or pill.
Comparative example 2
The comparative example discloses a pharmaceutical composition for preventing and treating urinary calculus of fattening sheep, which comprises the following components in percentage by mass: 40% of longhairy antenoron herb; 12% of spora lygodii; 4% of semen plantaginis; 15% of fringed pink and 29% of glucose oxidase.
Pulverizing 40g of herba Lysimachiae Christinae, 4g of semen plantaginis and 15g of herba Dianthi, and sieving with a sieve having a pore size of 125 μm to obtain fine powder and coarse powder of each component respectively; decocting the coarse powder and spora Lygodii 12g with rice washing water 300g for 45 min for 3 times, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.50 at 50 deg.C to obtain concentrated solution; mixing the fine powder, glucose oxidase 29g and concentrated solution, drying, adding pharmaceutically acceptable vehicle, and making into tablet, capsule, granule or pill.
Example 5
SD rats are taken as experimental samples, the SD rats are divided into 8 groups, calcium ethylene glycol oxalate is used, ammonium chloride is added at the same time, and animal lithangiuria modeling experiments are carried out after three weeks. Thereafter, among them, the experimental group (each group was administered with water after molding the pharmaceutical compositions of examples 1 to 4 of the present invention and comparative examples 1 to 2), the 7 th group was the longhairy antenoron herb granule control group (after molding, the bought littlements of the lithagogue herb granules were administered with water), the 8 th group was the blank control group (after molding, the water was administered with water), and three weeks later, the results of examination were as in table 1.
TABLE 1 urinary calculus formation in each experimental group
As can be seen from Table 1, the groups of examples 1 to 4 had substantially no calculus, and the test animals showed no particular abnormal state and no significant side effects during the experiment; in the comparative examples 1-2, half of the calculi were eliminated, and the test animals had abnormal mind and dribbling during the experiment; the calculus of the herba Lysimachiae Christinae granule control group is eliminated by 80%, the animal in the experiment period has slight abnormal spirit, and no obvious side effect; the sizes of the stones in the blank control group are not changed, and the experimental animals have abnormal spirits and uneasiness; abdominal distension; the arch and back do not allow normal urination. The experimental result shows that the pharmaceutical composition has obvious effects of treating and preventing the kidney stone and improving the diuresis.
Example 6
Taking SD rats as experimental samples, dividing the SD rats into 5 groups; groups 1-4 were experimental groups, and SD rats were fed with the pharmaceutical compositions obtained in examples 1-4, and the maximum tolerance of the experimental groups 1-4 was measured to be 30g/kg within 24 hours; group 5 was a control group given an equal volume of saline. No obvious abnormal reaction is observed in 1-5 groups after the drug is taken for 2 hours. After 7d of continuous observation, the appearance, behavior, weight increase and the like of the SD rat are not obviously different from those of a control group, the death condition of the SD rat does not appear, the anatomical observation of each group of SD rat is carried out by naked eyes, and the heart, the liver, the spleen, the lung, the kidney, the adrenal gland, the intestine and other organs of the SD rat in the administration group are also not obviously changed and have no obvious difference compared with the control group.
Example 7
In 2018, when a certain sheep farm in Hebei Tang county occurs urinary calculus diseases on a large scale, 500 fattening sheep can discharge a small amount of urine after using the pharmaceutical composition prepared in example 1 for 18-36 h, the symptom of urination pain is relieved, and urination can be recovered to be normal after 48-72 h, so that a good curative effect is obtained.
The invention provides a pharmaceutical composition for preventing and treating sheep lithangiuria and a preparation method thereof, which is prepared by compounding lysimachia, lygodium japonicum, plantain seed, fringed pink and glucose oxidase, and has strong calculus eliminating effect and the effects of clearing damp heat, eliminating infection and the like; in addition, the pharmaceutical composition is prepared into tablets, capsules, granules or pills by technical methods of crushing, screening, decocting, drying and the like, and is suitable for various feeding methods.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (6)
1. The pharmaceutical composition for preventing and treating urinary calculus of fattening sheep is characterized by comprising the following components in percentage by mass:
30 to 35 percent of desmodium;
5 to 10 percent of Japanese climbing fern spore;
5 to 10 percent of plantain seed;
5 to 10 percent of fringed pink;
40-55% of glucose oxidase;
and the sum of the mass fractions of the components is 100 percent.
2. The pharmaceutical composition for preventing and treating urinary tract stones of fattening sheep according to claim 1 is characterized by comprising the following components in percentage by mass:
30 to 32 percent of desmodium;
8 to 10 percent of Japanese climbing fern spore;
5 to 7 percent of plantain seed;
6 to 8 percent of fringed pink;
45-50% of glucose oxidase;
and the sum of the mass fractions of the components is 100 percent.
3. The pharmaceutical composition for preventing and treating urinary tract stones of fattening sheep according to claim 1 or 2, wherein the drugs are tablets, capsules, granules or pills.
4. The preparation method of the pharmaceutical composition for preventing and treating urinary tract stones of fattening sheep according to any one of claims 1 to 3 is characterized by comprising the following specific steps:
(1) pulverizing herba Lysimachiae Christinae, semen plantaginis and herba Dianthi, and sieving to obtain fine powder and coarse powder of each component respectively;
(2) decocting the coarse powder and spora Lygodii with rice washing water, mixing decoctions, filtering, and concentrating the filtrate to relative density of 1.50-1.52 at 50 deg.C to obtain concentrated solution;
(3) mixing the fine powder, glucose oxidase and the concentrated solution, drying, and making into tablet, capsule, granule or pill with pharmaceutically acceptable carrier.
5. The preparation method of the pharmaceutical composition for preventing and treating urinary tract stones of fattening sheep as claimed in claim 4, wherein the aperture of the mesh sieve in step (1) is 125 μm.
6. The preparation method of the pharmaceutical composition for preventing and treating urinary tract stones of fattening sheep as claimed in claim 4, wherein the decocting method in step (2) is decocting 3 times, each time for 40-60 minutes.
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