CN109223727A - A kind of production method of bacteria cellulose Capsules - Google Patents
A kind of production method of bacteria cellulose Capsules Download PDFInfo
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- CN109223727A CN109223727A CN201811177284.6A CN201811177284A CN109223727A CN 109223727 A CN109223727 A CN 109223727A CN 201811177284 A CN201811177284 A CN 201811177284A CN 109223727 A CN109223727 A CN 109223727A
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- Prior art keywords
- bacteria cellulose
- capsules
- capsule shell
- capsule
- cellulose capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
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- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
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- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The production method that the present invention discloses a kind of bacteria cellulose Capsules, belongs to field of medicaments, comprising the following steps: (1) production of bacteria cellulose.Wood gluconacetobacter is first activated, the wood gluconacetobacter after activation is seeded to section's sub- liquid in culture medium according to the inoculum concentration of certain volume ratio then, is put into stationary culture in constant incubator.The bacteria cellulose for then taking out generation, is put into immersion treatment in NaOH solution, then with the distilled water flushing of flowing, until the pH of flushing liquor is close to neutrality.(2) preparation of bacteria cellulose Capsules.Pure bacteria cellulose is put into after breaking into paste in beater, is poured onto capsule shell mold apoplexy dry forming.The bacteria cellulose Capsules that the present invention obtains are without any toxicity and side effects.Even if taking for a long time, adverse effect will not be generated to human body.And simple process is reasonable, at low cost, safe and reliable, is suitable for pharmacy relevant enterprise and produces in enormous quantities, has preferable market prospects.
Description
Technical field
The present invention relates to a kind of preparation processes of bacteria cellulose Capsules, belong to field of medicaments.
Background technique
Bacteria cellulose refer at different conditions, by acetic acid Pseudomonas, Agrobacterium, rhizobium etc. certain is micro-
The general designation of the cellulose of biosynthesis.It has many unique compared with plant cellulose, artificial synthesized bacteria cellulose
Property.
1. bacteria cellulose, without the associations product such as lignin, pectin and hemicellulose, has height compared with plant cellulose
Crystallinity and the high degree of polymerization；
2. hyperfine reticular structure.Bacteria cellulose fibre is to be combined into 40~60 nanometers by 3~4 nanometers of diameter of fento
Thick fibre bundle, and it is intertwined to form flourishing hyperfine network structure；
3. the elasticity modulus of bacteria cellulose is the several times of general plant fiber to ten times or more, and tensile strength is high；
4. bacterial fibers are known as higher biocompatibility, adaptability and good biodegradability；
5. Modulatory character when bacteria cellulose biosynthesis.
Bacteria cellulose Capsules are by the pure refined cap of bacteria cellulose addition auxiliary material, two section capsule shells of body
Composition.It is mainly used for containing solid or liquid medicine.Solves the problem of difficult entrance, poor taste for user, especially to baby children
It is no longer bitter to the taste really to realize good medicine for the drug administration process of youngster.Therefore Capsules are becoming increasingly popular.Firstly, the property of capsule
Shape is in elongated ellipsoid shaped, is easy to swallow hypopharynx, is dosage form most popular with consumers.In addition, capsule can be covered effectively
The taste and smell beastly of inherent drug.Finally, the size of capsule can be varied, can also print as needed
Text, trade mark and pattern processed, so that specific customization appearance is preferably presented.
Currently, in pharmaceuticals industry, it is common to use the drug capsules taken, shell majority is by gelatine starch and change
A point composition is studied, largely takes for a long time, certain adverse effect can be generated to human body.In addition, gelatin hollow capsule there are it is brittle,
The problems such as easily adhering to, and bacteria cellulose Capsules can then avoid problem above.
Summary of the invention
When the technical problems to be solved by the invention, a kind of capsule shell manufacture craft is provided, is to mention more specifically
For a kind of manufacture craft by bacteria cellulose production capsule shell.
In order to solve the above technical problems, the technical solution adopted by the present invention is that: a kind of manufacture craft of Capsules, it is described
Capsule manufacture craft be divided into following steps:
Wood gluconacetobacter is first activated, then seed liquor is inoculated into culture medium according to the inoculum concentration that volume ratio is 4%,
It is put into stationary culture 6d in 30 DEG C of constant incubators.The bacteria cellulose film for then taking out generation, is put into NaOH solution and impregnates
Processing, then with the distilled water flushing of flowing, until the pH of flushing liquor is close to neutral.
Bacteria cellulose film obtained above is put into beater, 12000rpm polishes 10 minutes；
Above-mentioned gained paste bacteria cellulose is subjected to sterilization treatment.
Paste bacteria cellulose after sterilizing is poured onto capsule shell mold, dry, cooling, air-dried molding；
Drug is poured into a capsule shell, another capsule shell is covered in the capsule shell mouth for having poured into drug
Place, to closed capsule.
It is an advantage of the invention that capsule shell manufacture craft of the invention, unique constituent are exactly bacterial fibers
Element, bacteria cellulose is a kind of pure edible bacteria cellulose, even if taking for a long time, to human body also without any damage,
Without any toxicity and side effects, and production method is simple.
Specific embodiment
The invention discloses a kind of manufacture craft of Capsules, the Capsules manufacture craft is divided into following step
It is rapid:
In order to further disclose technical solution of the present invention, the embodiment that hereby the present invention will be described in detail:
Embodiment 1:
Wood gluconacetobacter is first activated, then seed liquor is inoculated into culture medium according to the inoculum concentration that volume ratio is 2%,
It is put into stationary culture 6d in 30 DEG C of constant incubators.The bacteria cellulose film for then taking out generation, is put into NaOH solution and impregnates
Processing, then with the distilled water flushing of flowing, until the pH of flushing liquor is close to neutral；Bacteria cellulose film obtained above is put into
In beater, 10000rpm polishes 10 minutes；Above-mentioned gained paste bacteria cellulose is subjected to sterilization treatment.By the paste after sterilizing
Shape bacteria cellulose is poured onto capsule shell mold, dry, cooling, air-dried molding；Drug is poured into a capsule shell,
Another capsule shell is covered at the capsule shell mouth for having poured into drug, to closed capsule.
Embodiment 2:
Wood gluconacetobacter is first activated, then seed liquor is inoculated into culture medium according to the inoculum concentration that volume ratio is 3%,
It is put into stationary culture 7d in 30 DEG C of constant incubators.The bacteria cellulose film for then taking out generation, is put into NaOH solution and impregnates
Processing, then with the distilled water flushing of flowing, until the pH of flushing liquor is close to neutral；Bacteria cellulose film obtained above is put into
In beater, 12000rpm polishes 7 minutes；Above-mentioned gained paste bacteria cellulose is subjected to sterilization treatment.By the paste after sterilizing
Shape bacteria cellulose is poured onto capsule shell mold, dry, cooling, air-dried molding；Drug is poured into a capsule shell,
Another capsule shell is covered at the capsule shell mouth for having poured into drug, to closed capsule.
Embodiment 3:
Wood gluconacetobacter is first activated, then seed liquor is inoculated into culture medium according to the inoculum concentration that volume ratio is 4%,
It is put into stationary culture 6d in 30 DEG C of constant incubators.The bacteria cellulose film for then taking out generation, is put into NaOH solution and impregnates
Processing, then with the distilled water flushing of flowing, until the pH of flushing liquor is close to neutral；Bacteria cellulose film obtained above is put into
In beater, 8000rpm polishes 15 minutes；Above-mentioned gained paste bacteria cellulose is subjected to sterilization treatment.By the paste after sterilizing
Shape bacteria cellulose is poured onto capsule shell mold, dry, cooling, air-dried molding；Drug is poured into a capsule shell,
Another capsule shell is covered at the capsule shell mouth for having poured into drug, to closed capsule.
Claims (6)
1. a kind of bacteria cellulose Capsules, it is that bacterium fibre is being generated after culture medium stationary culture by wood gluconacetobacter
Tie up plain film.The bacteria cellulose film of generation passes through NaOH solution immersion treatment, and distillation water washing obtains pure bacteria cellulose.
It is characterized by: obtained pure bacteria cellulose can be put into Capsules model, to produce specific shape
The bacteria cellulose Capsules of size dimension.
A kind of production method of bacteria cellulose Capsules, which comprises the following steps:
Wood gluconacetobacter is first activated, then seed liquor is inoculated into culture medium according to the inoculum concentration that volume ratio is 4%, is put into
Stationary culture 6d in 30 DEG C of constant incubators.The bacteria cellulose film for then taking out generation is put into immersion treatment in NaOH solution,
The distilled water flushing of flowing is used again, until the close neutrality of the pH of flushing liquor.
Bacteria cellulose film obtained above is put into beater, 12000rpm polishes 10 minutes；
Above-mentioned gained paste bacteria cellulose is subjected to sterilization treatment.
Paste bacteria cellulose after sterilizing is poured onto capsule shell mold, dry, cooling, air-dried molding；
Drug is poured into a capsule shell, another capsule shell is covered at the capsule shell mouth for having poured into drug, is used
With closed capsule.
2. bacteria cellulose Capsules according to claim 1, it is characterised in that: the thickness of bacteria cellulose exists
Between 0.25cm-0.6cm.
3. bacteria cellulose Capsules according to claim 2, it is characterised in that: the Capsules thickness is about
0.03mm。
4. bacteria cellulose Capsules according to claim 3, it is characterised in that: the Capsules contain cap, body
Two section capsule shells.
5. bacteria cellulose Capsules according to claim 4, it is characterised in that: cap, the body two of the Capsules
Section, which has, is overlapped locking device.
6. bacteria cellulose Capsules according to claim 5, it is characterised in that: certain disease can be treated by having in capsule
The powdered or graininess or liquid medicine of disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811177284.6A CN109223727A (en) | 2018-10-11 | 2018-10-11 | A kind of production method of bacteria cellulose Capsules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811177284.6A CN109223727A (en) | 2018-10-11 | 2018-10-11 | A kind of production method of bacteria cellulose Capsules |
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| Publication Number | Publication Date |
|---|---|
| CN109223727A true CN109223727A (en) | 2019-01-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811177284.6A Pending CN109223727A (en) | 2018-10-11 | 2018-10-11 | A kind of production method of bacteria cellulose Capsules |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946882A (en) * | 2019-12-25 | 2020-04-03 | 西南大学 | Preparation method of capsule for mice based on Veillonella |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101509026A (en) * | 2009-03-27 | 2009-08-19 | 上海应用技术学院 | Bacteria cellulose compound film, preparation and uses thereof |
| US20120308649A1 (en) * | 2011-06-02 | 2012-12-06 | Food Industry Research And Development Institute | Bacterial cellulose composite with capsules embedded therein and preparation thereof |
| CN105567760A (en) * | 2016-01-13 | 2016-05-11 | 山东贝诺医药生物科技有限公司 | Preparation method of bacterial cellulose composite modified film |
| CN106755180A (en) * | 2016-12-09 | 2017-05-31 | 浙江理工大学 | A kind of method that utilization bacterium static fermentation prepares bio-modification bacteria cellulose NF membrane |
| US9770405B1 (en) * | 2011-10-05 | 2017-09-26 | The United States Of America As Represented By The Administrator Of Nasa | Biocompatible capsules and methods of making |
| CN107674892A (en) * | 2017-11-20 | 2018-02-09 | 天津科技大学 | A kind of preparation method of high ability of anti-deformation bacteria cellulose |
-
2018
- 2018-10-11 CN CN201811177284.6A patent/CN109223727A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101509026A (en) * | 2009-03-27 | 2009-08-19 | 上海应用技术学院 | Bacteria cellulose compound film, preparation and uses thereof |
| US20120308649A1 (en) * | 2011-06-02 | 2012-12-06 | Food Industry Research And Development Institute | Bacterial cellulose composite with capsules embedded therein and preparation thereof |
| US9770405B1 (en) * | 2011-10-05 | 2017-09-26 | The United States Of America As Represented By The Administrator Of Nasa | Biocompatible capsules and methods of making |
| CN105567760A (en) * | 2016-01-13 | 2016-05-11 | 山东贝诺医药生物科技有限公司 | Preparation method of bacterial cellulose composite modified film |
| CN106755180A (en) * | 2016-12-09 | 2017-05-31 | 浙江理工大学 | A kind of method that utilization bacterium static fermentation prepares bio-modification bacteria cellulose NF membrane |
| CN107674892A (en) * | 2017-11-20 | 2018-02-09 | 天津科技大学 | A kind of preparation method of high ability of anti-deformation bacteria cellulose |
Non-Patent Citations (1)
| Title |
|---|
| 吕鸿皓等: "细菌纤维素特性及其应用", 《食品安全质量检测学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946882A (en) * | 2019-12-25 | 2020-04-03 | 西南大学 | Preparation method of capsule for mice based on Veillonella |
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Application publication date: 20190118 |