CN109200071A - The purposes of Chinese sumac fruit or its extract - Google Patents
The purposes of Chinese sumac fruit or its extract Download PDFInfo
- Publication number
- CN109200071A CN109200071A CN201811170412.4A CN201811170412A CN109200071A CN 109200071 A CN109200071 A CN 109200071A CN 201811170412 A CN201811170412 A CN 201811170412A CN 109200071 A CN109200071 A CN 109200071A
- Authority
- CN
- China
- Prior art keywords
- extract
- liver
- chinese sumac
- alcoholic fatty
- fatty liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 49
- 239000000284 extract Substances 0.000 title claims abstract description 48
- 240000003152 Rhus chinensis Species 0.000 title claims abstract description 46
- 235000014220 Rhus chinensis Nutrition 0.000 title claims abstract description 45
- 208000026594 alcoholic fatty liver disease Diseases 0.000 claims abstract description 34
- 208000010706 fatty liver disease Diseases 0.000 claims abstract description 34
- 208000007082 Alcoholic Fatty Liver Diseases 0.000 claims abstract description 32
- 206010016262 Fatty liver alcoholic Diseases 0.000 claims abstract description 32
- 231100000753 hepatic injury Toxicity 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 10
- 230000002265 prevention Effects 0.000 claims abstract description 10
- 235000013402 health food Nutrition 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 206010067125 Liver injury Diseases 0.000 claims abstract description 4
- 239000006286 aqueous extract Substances 0.000 abstract description 3
- 230000003449 preventive effect Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 239000000469 ethanolic extract Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 41
- 235000019441 ethanol Nutrition 0.000 description 36
- 241000700159 Rattus Species 0.000 description 22
- 210000004185 liver Anatomy 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 210000005229 liver cell Anatomy 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 208000019425 cirrhosis of liver Diseases 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 208000031226 Hyperlipidaemia Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000007882 cirrhosis Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 235000020097 white wine Nutrition 0.000 description 4
- 235000014101 wine Nutrition 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000004930 Fatty Liver Diseases 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 206010019708 Hepatic steatosis Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 241000208223 Anacardiaceae Species 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 206010009208 Cirrhosis alcoholic Diseases 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 244000044283 Toxicodendron succedaneum Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 210000005161 hepatic lobe Anatomy 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000009200 high fat diet Nutrition 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses the application of Chinese sumac fruit or its extract in preparation treatment and/or prevention alcoholic fatty liver and liver injury medicament and health food；The present invention verifies the extract for preventing and treating alcoholic fatty liver of Chinese sumac fruit and hepatic injury by zoopery respectively；Experimental result confirms that Chinese sumac fruits aqueous extract and ethanol extract have significant preventive and therapeutic effect to alcoholic fatty liver and hepatic injury；And the cheap, widely distributed of Chinese sumac fruit, plantation are simple, raw material is easy to get；These comprehensive reasons, Chinese sumac fruit or its extract possess preferable exploitation prospect in terms of preparation prevention and treatment alcoholic fatty liver and liver injury medicament and health food.
Description
Technical field
The present invention relates to Chinese sumac fruits or its extract in preparation treatment and/or prevention alcoholic fatty liver and hepatic injury
Health food or drug in application, belong to food or pharmaceutical technology field.
Background technique
Alcoholic fatty liver (alcoholic fatty liver disease, AFLD) is liver caused by excessive consumption of alcohol
Cellular damage disease, it is reversible to be further development of liver fibrosis and cirrhosis, show as gradual liver fat
Denaturation, hepatitis, liver fibrosis and cirrhosis.Alcohol is slowly a small amount of under one's belt to be absorbed, mainly logical in duodenum and upper section ileum
Cross simple diffusion absorption.Only 2%~10% is discharged by lungs and kidney, remaining 90%~98% is metabolized in liver internal oxidition.
About 90% heavy drinker (Ethanol intake is more than 60 grams/day) suffers from alcoholic fatty liver, wherein there is 10%~35% weight
Degree alcohol user can be further developed into alcoholic hepatitis, and 5%~15% heavy drinker can develop into cirrhosis.AFLD is in liver
Quite high ratio is accounted in disease incidence, in some drink universal countries such as China, Russia, the U.S., France, Germany, meaning
Big benefit, Spain etc., the disease incidence of alcoholic liver disease is higher, and data shows that alcoholic cirrhosis morbidity accounts for all cirrhosis
50%~75%.Drinking is the very traditional eating habit in one, China, and as the living standard of our people constantly increases,
Also cumulative year after year, the disease incidence so as to cause alcoholic fatty liver disease in crowd obviously rise the consumption of alcohol product.But
Targeted target treatment method is but clinically lacked to the treatment of AFLD at present, it can only be passively based on anti symptom treatment
(prevent and treat malnutrition with nutritional support and controlled inflammation with glucocorticoid) there is no prevention and treatment alcoholic fatty liver and liver damage
The specific drug of wound.At present the whole world all the positive method and natural products for finding prevention and treatment alcoholic fatty liver and hepatic injury to
Cope with increasingly serious alcoholic fatty liver and hepatic injury related disease problem.Therefore, to traditional dual-purpose of drug and food herbal control
The exploitation of alcoholic fatty liver and hepatic injury is extremely important.
Chinese sumac (Rhus chinensis Mill.) fruit also known as Chinese sumac fruit, slave's salt of betraing, salt plum etc. are that Anacardiaceae is planted
The fruit of object Chinese sumac.It is born in the lime mountain shrubbery of height above sea level 350-2300 m, in sparse woods.For the wild light demanding tree that China is common.
It is distributed the ground such as northeast and Yunnan, Sichuan, Shanxi, Anhui, Jiangsu, Guangxi.Lacquer tree is of less demanding to edaphic condition, is common in and does not plough
Ground is also well-known the gallic main body of Chinese aphid.Chinese sumac early has been used for treatment disease in ancient Chinese various regions.Example
Such as, Chinese sumac leaf is for treating inflammation and diarrhea；Root is for treating malaria and jaundice；Fruit and seed are frequently used for treatment dysentery
Disease.Compared with other positions, fruit acts not only as herbal medicine use, is also used as flavouring and beverage uses.In addition, at
Ripe fruit is often eaten in some places of China freshly.At present both at home and abroad to Chinese sumac fruit extract for preventing and treating alcohol fatty
The correlative study of liver and hepatic injury there are no document report.
Summary of the invention
It is an object of that present invention to provide the new application of Chinese sumac fruit or its extract in terms of medicine and health food, tools
It is exactly to apply Chinese sumac fruit or its extract to treat and/or prevent alcoholic fatty liver and hepatic injury etc. in preparation for body
In related disease in novel drugs and new health food.
This invention address that Chinese sumac fruit prevention and treatment alcoholic fatty liver and the experimental study of hepatic injury, by multiple pathways
Confirm that Chinese sumac fruit or its extract have significant protective effect to alcoholic fatty liver and hepatic injury.
Chinese sumac fruit extract is the water extract or alcohol extracting thing of Chinese sumac fruit in the present invention.
The present inventor prevents and treats alcoholic fatty liver to Chinese sumac fruit and hepatic injury has carried out the research of series, it was confirmed that salt
Skin wood fruit extract has the function of exact Liver protection, therefore can be used for preventing and treating alcoholic fatty liver and hepatic injury new drug and new
The preparation and exploitation of health food.Chinese sumac fruit extract is used to prepare prevention and treatment alcoholic fatty liver and liver injury medicament and guarantor
Health food have these following advantages: Chinese sumac plant is adapted to various severe natural environments, China distribution very
It is extensive, fruit price is very cheap；On the ground such as Yunnan, Chinese sumac fruit is often used as the production of flavouring and drink
Raw material is a kind of fruit of traditional dual-purpose of drug and food, highly-safe；The process flow extracted and prepared is simple, market prospects are considerable,
Contain huge society and economic benefits.
Compared with prior art, the present invention has the advantage that
1, the present invention is that Chinese sumac fruit has excavated new health food or medical application, has opened up a new research field；
2, the present invention is found through experiments that Chinese sumac fruit difference extract can effectively check alcohol under low concentration
Property Models of Fatty Liver rat liver in lipochondrion deposition, and extract from be used as seasoning natural plants former material
Material, it is highly-safe.
Detailed description of the invention
Fig. 1 is after alcohol combines rat alcoholic fatty liver caused by high lipid food and the intervention of Chinese sumac fruit difference extract
Hepatic pathology section H&E colored graph (H&E × 200), wherein A be control group；B is model group；C is alcohol extract low concentration
Group；D is alcohol extract high concentration group；E is water extract low concentration group；F is water extract high concentration group.
Specific embodiment
Carry out the present invention further elucidated above below with reference to the data of pathological section attached drawing and experiment embodiment.The thing of these experiments
Example is merely to illustrate the present invention, is not used in and limits application range of the invention.After having read record of the invention, this field
Scientific and technical personnel's various changes, modification and modification equivalent to its, belong to the scope of the claims in the present invention.
The example of alcoholic fatty liver
The model that alcoholic fatty liver is established using the method that stomach-filling alcohol combines feeding high lipid food, passes through animal model experiment
The alcohol extracting thing and water extract for observing Chinese sumac fruit are to the preventive and therapeutic effect of alcoholic fatty liver and hepatic injury.
1. experimental material
1.1 animals, feed and reagent
SD male rat, the long-living Biotechnology Ltd. in Liaoning.High lipid food, into how rich biological Co., Ltd.56 ° red
Star strong, colourless liquor distilled from sorghum, Hongxing Co., Ltd. Beijing.Biotechnology Co., Ltd is built up in kit, Nanjing.
1.2 extract
Chinese sumac fruit extract uses ethyl alcohol or boiling water mainly to extract wherein effective component.The specific method is as follows: water extracts
Object mainly simulates the characteristic decocted in pharmacopeia, boils in boiling water 1 hour, solid-liquid ratio 1:20；It is centrifuged, turns while hot after boiling
4000 r/min of speed, supernatant are filtered, filter later sample and be concentrated, and finally freeze-drying is made, for use.
Alcohol extracting thing carries out ultrasonic extraction using the ethanol solution of mass concentration 80%, and Extracting temperature is 25 DEG C, and solid-liquid ratio is
1:5 extraction time is 30 min, and filter residue mentions once again, and then 4000 r/min centrifuging and taking supernatants are concentrated freeze-dried is made.
1.3 instrument
Automatic clinical chemistry analyzer, Rayto Life and Analytical Sciences Co., Ltd..
2. method and result
2.1 modeling
Male rat is all the SPF grade SD rat of 4-8 week old, weight of the weight in 200 g left-right deviations 5% or so.Experimental animal
From the long-living Biotechnology Ltd. in Liaoning, the number of rat is SCKK(the Liao Dynasty) 2015-0001.Specifically 60
Mouse is divided into 6 groups (10, every cages), and each two groups of water extract, alcohol extracting thing；It numbers as follows:
Group 1: control group (mainly with distilled water stomach-filling, N), 2 model group of Group (white wine stomach-filling, M), 3 alcohol of Group
Extract low concentration 300mg/kg(fills wine and alcohol extracting thing, AL), 4 alcohol extracting thing high concentration of Group, 900 mg/kg(fill wine
And alcohol extracting thing, AH), 5 water extract low concentration of Group, 300 mg/kg(fill wine and water extract, WL), 6 water of Group
900 mg/kg(of extract high concentration fills wine and water extract, WH).All 12 h of animal fasting before being administered for the first time, and
The weight (can't help water) of each mouse is recorded before administration.According to the rat feeding environment raising rat of standard (after purchase, in the ring
It is adapted to seven days under border).The mode of modeling is as follows: 9 points of every morning the stomach-filling volume with 5mL/kg, pour into two classes of matched doses
Extract or distilled water, the white wine of corresponding volume is then poured into after 30min, and (control group does not fill white wine, with distilled water generation
It replaces, and the volume in total of white wine and extract is no more than the volume of stomach-filling).After stomach-filling, each group is given feeding high in fat
The nursing of material.After raising 80 days, to all Rat Fast 12h, using 10% chloral hydrate anesthesia rat, weighing is taken
It is to be measured that blood is made serum, then carries out blood serum bio-chemical analysis；It takes liver to weigh, then takes left lobe of liver, be immersed in 10% Fu Er
In Malin's solution, to subsequent progress H&E dyeing.
2.2 result
2.2.1 influence of the Chinese sumac fruit extract to alcoholic fatty liver in rats weight and liver index
Influence of the 1. Chinese sumac fruit extract of table to alcoholic fatty liver in rats weight and liver index
Note:*Indicate model group have compared with blank control group significant difference (P< 0.05),#Indicate administration group and model group
Compared to have significant difference (P< 0.05)；
Compared with blank control group, the liver index of hyperlipidemia model group significantly increase (P< 0.05)；And with hyperlipidemia model group phase
Than, the water extract and alcohol extracting thing of Chinese sumac fruit can be significantly reduced liver index (P< 0.05), but final weight is each
Do not differed significantly between a group (P> 0.05).
2.2.2 influence of the Chinese sumac fruit extract to alcoholic fatty liver in rats blood lipid and liver function enzyme
Influence of the 2. Chinese sumac fruit extract of table to alcoholic fatty liver in rats blood lipid and liver function enzyme
Note:*Indicate model group have compared with blank control group significant difference (P< 0.05),#Indicate administration group and model group
Compared to have significant difference (P< 0.05)；
Compared to the blank group, the triglyceride in model group serum and total cholesterol level all conspicuousnesses rising (P <
0.05).And compared with model group, Chinese sumac fruits aqueous extract and alcohol extracting thing can significantly reduce the glycerol three in serum
Rouge and total cholesterol content (P< 0.05).In addition, from Table 2, it can be seen that compared to the blank group, in model group serum
ALT and AST content significantly increase (P< 0.05), illustrate that alcohol adds high fat diet to cause significantly rat liver cells
Damage；But compared with model group, in the rat blood serum of each administration group ALT and AST content be remarkably decreased (P< 0.05) it, says
Bright Chinese sumac fruit extract can effectively prevent the alcohol extract of hepatic injury caused by alcohol, especially high concentration, thin to liver
The alcohol damaged protective effect of born of the same parents is most strong, and ALT and AST are returned to normal.
2.2.3 influence of the Chinese sumac fruit extract to alcoholic fatty liver in rats liver rouge
Influence of the 3. Chinese sumac fruit extract of table to alcoholic fatty liver in rats liver rouge
Note:*Indicate model group have compared with blank control group significant difference (P< 0.05),#Indicate administration group and model group
Compared to have significant difference (P< 0.05)；
In the liver of animal, compared with blank control group, triglycerides and total cholesterol contains in the liver of hyperlipidemia model rat
Amount is significant to be increased (P< 0.05).And compared with hyperlipidemia model group, the water extract or alcohol extracting thing of Chinese sumac fruit are handled
Group content of triglyceride be remarkably decreased (P< 0.05), and with blank control group be not significantly different (P> 0.05), this
One result can mutually be confirmed with corresponding liver section, further confirm that the water of Chinese sumac fruit or alcohol extracting thing can be effective
Prevention and treatment alcoholic fatty liver.In addition, total gallbladder in liver can be significantly reduced in high concentration alcohol extracting thing and low concentration of water extract
Sterol content (P< 0.05).
2.2.4 influence of the Chinese sumac fruit extract to alcoholic fatty liver in rats hepatic tissue pathology situation
As shown in Figure 1, in light microscopic observation alcohol fatty liver slice, the rat of blank group is sliced rat liver pathological section
The shape of middle liver cell is normal, and cell nuclear state is normal, and is formed in liver cell without apparent fat granule.It, can in model group
Significantly to observe that the damage of nucleus assembled with liver cell moreover also has apparent fat granule in liver cell
It is formed.Alcohol is damaged caused by liver in the slice of alcohol extracting thing is greatly reduced, and fat granule formation is seldom.Equally, salt
Skin wood fruits aqueous extract can also inhibit significantly alcohol to the damage of liver cell and the formation of fat granule.
In summary: can determine that the extract of Chinese sumac fruit can effectively inhibit fat caused by long-term alcohol
Accumulation in liver cell, and can effectively prevent damage of the alcohol to liver cell.So that it is determined that Chinese sumac fruit and its mentioning
Take object that can prevent and treat alcoholic fatty liver and hepatic injury.
Claims (2)
1. Chinese sumac fruit or its extract answering in preparation treatment and/or prevention alcoholic fatty liver and liver injury medicament
With.
2. Chinese sumac fruit or its extract are in preparation treatment and/or prevention alcoholic fatty liver and hepatic injury health food
Using.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811170412.4A CN109200071A (en) | 2018-10-09 | 2018-10-09 | The purposes of Chinese sumac fruit or its extract |
| PCT/CN2019/109409 WO2020073869A1 (en) | 2018-10-09 | 2019-09-30 | Use of chinese sumac fruit or extract thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811170412.4A CN109200071A (en) | 2018-10-09 | 2018-10-09 | The purposes of Chinese sumac fruit or its extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109200071A true CN109200071A (en) | 2019-01-15 |
Family
ID=64983134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811170412.4A Pending CN109200071A (en) | 2018-10-09 | 2018-10-09 | The purposes of Chinese sumac fruit or its extract |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN109200071A (en) |
| WO (1) | WO2020073869A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020073869A1 (en) * | 2018-10-09 | 2020-04-16 | 昆明理工大学 | Use of chinese sumac fruit or extract thereof |
| CN112076236A (en) * | 2019-06-14 | 2020-12-15 | 昆明芳本生物科技发展有限公司 | Application of rhus chinensis fruit in preparation of medicine for treating or preventing non-alcoholic fatty liver disease |
| WO2020248964A1 (en) * | 2019-06-14 | 2020-12-17 | 昆明芳本生物科技发展有限公司 | Use of rhus chinensis fruit in preparation of drugs for treatment and/or prevention of hepatic fibrosis |
| CN113134021A (en) * | 2021-04-13 | 2021-07-20 | 昆明理工大学 | Application of rhus chinensis fruit or extract thereof in preparation of drug for preventing and treating drug-induced hepatitis and liver injury |
| CN115054621A (en) * | 2022-01-03 | 2022-09-16 | 昆明理工大学 | Application of rhus chinensis fruit or extract thereof in preventing and treating osteoporosis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101376866A (en) * | 2007-08-31 | 2009-03-04 | 中国科学院过程工程研究所 | Rhus chinensis fruit steam-explosion treatment and comprehensive utilization technology of lipid and flavone thereof |
| CN107913370A (en) * | 2017-04-24 | 2018-04-17 | 臧玮 | A kind of medicine and preparation method of therapy of combing traditional Chinese and Western medicine alcoholic liver disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101502798B1 (en) * | 2013-06-27 | 2015-03-18 | 주식회사 후드원 | Hepatic Fibrosis Cure Composition containing Methanol Extracts from Rhus Chinensis and Method for Producing the same |
| CN106551962B (en) * | 2016-11-21 | 2020-05-15 | 昆明理工大学 | Rhus chinensis fruit extract and preparation method and application thereof |
| CN109200071A (en) * | 2018-10-09 | 2019-01-15 | 昆明理工大学 | The purposes of Chinese sumac fruit or its extract |
-
2018
- 2018-10-09 CN CN201811170412.4A patent/CN109200071A/en active Pending
-
2019
- 2019-09-30 WO PCT/CN2019/109409 patent/WO2020073869A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101376866A (en) * | 2007-08-31 | 2009-03-04 | 中国科学院过程工程研究所 | Rhus chinensis fruit steam-explosion treatment and comprehensive utilization technology of lipid and flavone thereof |
| CN107913370A (en) * | 2017-04-24 | 2018-04-17 | 臧玮 | A kind of medicine and preparation method of therapy of combing traditional Chinese and Western medicine alcoholic liver disease |
Non-Patent Citations (8)
| Title |
|---|
| ARSHAD MEHMOOD ABBASI: "Medicinal plants used for the treatment of jaundice and hepatitis based on socio-economic documentation", 《AFRICAN JOURNAL OF BIOTECHNOLOGY》 * |
| CHENGTING ZHANG: "Phenolic composition, antioxidant and pancreatic lipase inhibitory", 《INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY》 * |
| HEIRANGKHONGJAM MEMTHOI DEVI: "Traditional medicinal uses and pharmacological properties of Rhus chinensis", 《EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE》 * |
| HESHENG LIU: "Protective effect of flavonoid extract from Chinese bayberry", 《J NAT MED》 * |
| 尹国有: "《肝胆病中医验案点评与误案分析》", 31 May 2015 * |
| 施军平: "《盐肤木果粕成分研究》", 30 April 2009 * |
| 李时珍: "《本草纲目》", 31 March 2009 * |
| 高洁莹: "盐肤木果粕成分研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020073869A1 (en) * | 2018-10-09 | 2020-04-16 | 昆明理工大学 | Use of chinese sumac fruit or extract thereof |
| CN112076236A (en) * | 2019-06-14 | 2020-12-15 | 昆明芳本生物科技发展有限公司 | Application of rhus chinensis fruit in preparation of medicine for treating or preventing non-alcoholic fatty liver disease |
| WO2020248964A1 (en) * | 2019-06-14 | 2020-12-17 | 昆明芳本生物科技发展有限公司 | Use of rhus chinensis fruit in preparation of drugs for treatment and/or prevention of hepatic fibrosis |
| CN113134021A (en) * | 2021-04-13 | 2021-07-20 | 昆明理工大学 | Application of rhus chinensis fruit or extract thereof in preparation of drug for preventing and treating drug-induced hepatitis and liver injury |
| CN115054621A (en) * | 2022-01-03 | 2022-09-16 | 昆明理工大学 | Application of rhus chinensis fruit or extract thereof in preventing and treating osteoporosis |
| CN115054621B (en) * | 2022-01-03 | 2023-12-22 | 昆明理工大学 | Application of Rhus chinensis fruit or extract thereof in preventing and treating osteoporosis |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020073869A1 (en) | 2020-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109200071A (en) | The purposes of Chinese sumac fruit or its extract | |
| CN106214773B (en) | A kind of pair of chemical damage has composition of assistant protection function and preparation method thereof | |
| CN109200136A (en) | A kind of Chinese medicine composition and its application for Antialcoholic liver-protecting | |
| KR101949887B1 (en) | Composition for relieving hangover or preventing or treating alcoholic liver disease comprising a complex extract of seaweed and complex extract of plant | |
| CN114632101B (en) | Cordyceps guangdongensis weight-losing lipid-lowering liver-protecting compound and preparation method and application thereof | |
| CN105106816B (en) | Protect the traditional Chinese medicine health care product preparation and preparation method thereof of chemical damage | |
| CN106138101A (en) | A kind of preparation method of Embryo Gallus domesticus extract | |
| CN101337009B (en) | Use of water hyacinth extract in preparing lipid-lowering medicine | |
| CN110201011A (en) | Euscaphis konishii extract is preparing the application in blood lipid-lowering medicine | |
| CN108542920A (en) | A kind of purposes of Lachnum melanin as anti-acute kidney injury drug | |
| CN114306398A (en) | Application of phellinus igniarius fermented extract | |
| CN107753531A (en) | Literary king's one-pen extract and its application in cancer therapy drug is prepared | |
| Cho et al. | Single-and repeated-dose toxicities of aloe fermentation products in rats | |
| CN112603978A (en) | Traditional Chinese medicine composition for treating type 2 diabetes combined with coronary heart disease and preparation method thereof | |
| CN102688263A (en) | Geranium strictipes effective part preparation and medical use of geranium strictipes for preventing and curing colonitis | |
| CN102258692A (en) | Dendrobium luminous pills and preparation method thereof | |
| CN110840950A (en) | Application of Russian tea and/or Russian tea extract in preparation of medicines for preventing and treating non-alcoholic liver disease and/or non-alcoholic liver injury | |
| KR20090092905A (en) | A pharmaceutical composition comprising extract of medicine plants for the treatment and prevention of diabetes | |
| CN104189101A (en) | Celandine seed fat-soluble part and hypolipidemic application thereof | |
| CN110339252A (en) | It is a kind of with Chinese medicine composition and preparation method thereof and product for alleviating nonalcoholic fatty liver disease | |
| CN111544440A (en) | Application of diosmin and composition in preparation of anti-obesity product | |
| CN112076236A (en) | Application of rhus chinensis fruit in preparation of medicine for treating or preventing non-alcoholic fatty liver disease | |
| CN101269152A (en) | Application of matrimony vine and black fungus in preparing fatty liver resistant medicament | |
| CN104688800B (en) | Application of the total saponins from Cornus officinalis in the drug of preparation prevention and treatment diabetic complication | |
| CN109700843A (en) | A kind of net vein Farfugium kaemferi extract and its application in prevention and treatment stomach trouble |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |