CN109172787A - A kind of graphene fat-reducing plaster and preparation method thereof - Google Patents

A kind of graphene fat-reducing plaster and preparation method thereof Download PDF

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Publication number
CN109172787A
CN109172787A CN201811113447.4A CN201811113447A CN109172787A CN 109172787 A CN109172787 A CN 109172787A CN 201811113447 A CN201811113447 A CN 201811113447A CN 109172787 A CN109172787 A CN 109172787A
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China
Prior art keywords
parts
graphene
fat
layer
reducing
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CN201811113447.4A
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Inventor
赵立春
唐农
宋策
钟余特
王雪
于培良
李俊秀
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Guangxi University of Chinese Medicine
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Guangxi University of Chinese Medicine
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Abstract

The invention discloses a kind of graphene fat-reducing plasters, it include basal layer, drug delivery layer and graphene nano layer, wherein drug delivery layer includes rheum officinale, Radix Glycyrrhizae, honeysuckle, Pigs Kidney rattan, delavay raspberry herb, safflower, cassia seed, dried orange peel, stir-baked FRUCTUS CRATAEGI, lotus leaf, Jasmine, Rhizoma Atractylodis Macrocephalae, Poria cocos, rhizoma alismatis, the tuber of pinellia, ginger, cassia bark, aloe, serissa serissoide, Siraitia grosvenorii, corn stigma, Semen Coicis, the fleece-flower root, honey and tea oil；Graphene nano layer includes graphene nanometer sheet.Final graphene fat-reducing plaster obtained is not only safe to the human body, will not generate any side effect, and can play good fat-reducing effect within a short period of time, and after treatment in 3 months, weight-reducing effective percentage reaches 95% or more.

Description

A kind of graphene fat-reducing plaster and preparation method thereof
Technical field
The present invention relates to a kind of fat-reducing plaster, more particularly to a kind of graphene weight-reducing.
Background technique
With the rapid development of economy, people's lives condition is become better and better, but with also generating a series of problems；Such as Due to diet is irregular, often gives up doing exercise etc., many people all obesities are badly in need of weight-reducing；Furthermore some are especially one A little schoolgirls are for the stature that keeps oneself slim, all with can go to lose weight by various modes；Weight-reducing mode most healthy at present is that movement subtracts Fertilizer, but this needs greatly to adhere to power, and many people are insufficient because of itself willpower or other objective factors all abandon this mode, Then lost weight by taking slimming drugs, although take slimming drugs has good fat-reducing effect, weight-reducing within a certain period of time Medicine has certain side effect and adverse reaction to human body, and slimming drugs are eaten for a long time, can make the functions of intestines and stomach disorder of human body, less serious case It will appear indigestion, severe one may cause a series of gastrointestinal disease.
In the prior art, application No. is the Chinese patents of CN200310100375.7 --- and fat-reducing plaster includes hawthorn, lotus The Chinese medicines such as leaf, rde bean, and by the way of outer patch, it is very safe, adverse reaction will not be caused, while also having and preferably subtracting Fertilizer efficiency fruit, but the fat-reducing effect of such fat-reducing plaster is slow, needs to lose weight using long time.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of graphene fat-reducing plaster, the fat-reducing plaster Safety, does not have injury to human body；Good fat-reducing effect can be played in a relatively short period of time simultaneously.
To achieve the above object, the present invention provides the following technical scheme that a kind of graphene fat-reducing plaster, includes substrate Layer, drug delivery layer and graphene nano layer, drug delivery layer are located above basal layer, and graphene nano layer is located above drug delivery layer；Administration Layer includes following parts by weight substance: 20-40 parts of rheum officinale；20-40 parts of Radix Glycyrrhizae；20-40 parts of honeysuckle；20-30 parts of Pigs Kidney rattan；Barb 20-30 parts of thorn；10-20 parts of safflower；10-20 parts of cassia seed；10-20 parts of dried orange peel；10-20 parts of stir-baked FRUCTUS CRATAEGI；10-20 parts of lotus leaf； 5-10 parts of Jasmine；5-10 parts of Rhizoma Atractylodis Macrocephalae；5-10 parts of Poria cocos；5-10 parts of rhizoma alismatis；5-10 parts of the tuber of pinellia；5-10 parts of ginger；Cassia bark 5-10 Part；5-10 parts of aloe；3-5 parts of serissa serissoide；3-5 parts of Siraitia grosvenorii；3-5 parts of corn stigma；3-5 parts of Semen Coicis；1-2 parts of the fleece-flower root；Honey 2-3 parts；2-3 parts of tea oil.
Preferably, drug delivery layer includes following parts by weight substance: 35 parts of rheum officinale；30 parts of Radix Glycyrrhizae；25 parts of honeysuckle；Pigs Kidney rattan 22 parts；23 parts of delavay raspberry herb；13 parts of safflower；15 parts of cassia seed；15 parts of dried orange peel；17 parts of stir-baked FRUCTUS CRATAEGI；15 parts of lotus leaf；8 parts of Jasmine； 8 parts of Rhizoma Atractylodis Macrocephalae；6 parts of Poria cocos；6 parts of rhizoma alismatis；6 parts of the tuber of pinellia；7 parts of ginger；5 parts of cassia bark；5 parts of aloe；4 parts of serissa serissoide；4 parts of Siraitia grosvenorii； 4 parts of corn stigma；3 parts of Semen Coicis；1 part of the fleece-flower root；3 parts of honey；2 parts of tea oil.
Graphene nano layer includes following parts by weight material composition:
60 parts of graphene nanometer sheet；
3 parts of ether of glycolic polyoxyethanyl laurel；
5 parts of propyl trimethoxy silicane of 3- (acryloxy)；
3 parts of diethyl phosphorus methyl acetate；
4 parts of ketone of 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4-；
(1S) -1- (2R) -5 parts of t-butyl formate of epoxy ethyl -2- PhenethyIamino；
4 parts of trifluoroacetamide of bis- (trimethyl silicon substrates).
A kind of preparation method of graphene fat-reducing plaster, comprising the following steps:
Step 1: rheum officinale 20-40g is weighed first；Radix Glycyrrhizae 20-40g；Honeysuckle 20-40g；Lotus leaf 10-20g；Jasmine 5- 10g；Rhizoma Atractylodis Macrocephalae 5-10g；Aloe 5-10g；Serissa serissoide 3-5g；Siraitia grosvenorii 3-5g；Then said medicine is cleaned into drying, after drying It is ground, was ground into 120 targeted fine powders；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times, each 1-3h altogether, is received Collect extracting solution, is then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density 1.05 Condensed cream one；
Step 3: by Pigs Kidney rattan 20-30g；Delavay raspberry herb 20-30g；Safflower 10-20g；Cassia seed 10-20g；Dried orange peel 10- 20g；Stir-baked FRUCTUS CRATAEGI 10-20g；Poria cocos 5-10g；Rhizoma alismatis 5-10g；Tuber of pinellia 5-10g；Ginger 5-10g；Cassia bark 5-10g；Corn stigma 3- 5g；Semen Coicis 3-5g；Fleece-flower root 1-2g cleans drying and honey 2-3g, tea oil 2-3g are put into togerther in 500ml pure water and impregnate 1- After 2h, first fast fire is fried open, then pan-fried 60min slowly, then takes out 200ml decocting liquid, 500ml pure water is added, and continues pan-fried 60min slowly, 200ml decocting liquid is taken out, 200ml pure water is added, then pan-fried 120min slowly, decocting liquid is poured out, mixes and stirs with preceding decocting liquid twice It is even；Decocting liquid obtained is concentrated under reduced pressure to the condensed cream two for being 1.10 at relative density；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: it is prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then according to matching Just by glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino formic acid The tert-butyl ester and 6 kinds of substances of bis- (trimethyl silicon substrate) trifluoroacetamides are added in graphene nanometer sheet, form graphene nano layer；
Step 6: coating ointment made from step 4 on the basal layer made of polyurethane material, ointment with a thickness of 0.5-1 millimeters, alkene nanometer layer of then graphiting on ointment is then sheared, and is modified, and packaging finally obtains graphene Fat-reducing plaster.
Clean drying in step 1 and step 3, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven and dries It is dry, drying time 20-30min.
Stirring evenly in step 2 is to stir 30-60min in the case where revolving speed is 500-800rad/s.
It is extracted in step 2 with ethyl alcohol, is extracted 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, is for the second time 300ml is for the third time 200ml.
Stirring evenly in step 4 refers to that in temperature be 50-60 DEG C, revolving speed 200-400rad/s, stirs 2h.
It is by graphene nanometer sheet, glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl front three in step 5 Oxysilane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- (trimethyl silicon substrate) trifluoroacetamides are placed in ultrasound together Sufficiently ultrasound 5 hours in device, graphene nano layer is obtained after ultrasound.
Beneficial effects of the present invention: promote enterocinesia by the way that using rheum officinale, Radix Glycyrrhizae, honeysuckle as main ingredient, rheum officinale has, suppression Enteral moisture absorption processed, promotes defecation and other effects, and Radix Glycyrrhizae has a polishing, clearing heat and detoxicating effect, honeysuckle have removing summer-heat blood poison, The effect of strengthen immunity, can not only promote adiposis patient to accelerate enterocinesia under this 3 kinds of Chinese medicine collective effects, be discharged various Toxin has good fat-reducing effect to adiposis patient, and can be improved the immunity of adiposis patient, ensures the strong of adiposis patient Health；And it can further be mentioned under Pigs Kidney rattan, delavay raspberry herb, safflower, cassia seed, stir-baked FRUCTUS CRATAEGI and lotus leaf this 6 kinds of Chinese medicine collective effects High fat-reducing effect enables fat-reducing plaster produced by the present invention just to have good fat-reducing effect in a relatively short period of time, so that fertile Fat patient's quick weight-lossing, stature of getting well；Due to using Radix Glycyrrhizae to be easy to cause the side reactions such as patient's indigestion；Pass through addition Dried orange peel, Jasmine, Rhizoma Atractylodis Macrocephalae, Poria cocos, rhizoma alismatis, the tuber of pinellia, ginger and cassia bark can not only remove under the interaction of this 8 taste Chinese medicine Because the side reaction of Radix Glycyrrhizae bring is added, guarantee that the drug paste can promote patient to drug to the safety of adiposis patient, while also It absorbs, accelerates the weight-reducing speed of patient；Also added aloe, serissa serissoide, Siraitia grosvenorii, corn stigma, Semen Coicis, the fleece-flower root, honey and Tea oil under this 8 kinds of Chinese medicine collective effects, can not only greatly improve the body immunity of adiposis patient, while can also play " profit The effect of cunning ", enables the pharmacological property of each Chinese medicine to bring into play completely, ensure that the fat-reducing plaster has good fat-reducing effect.
As another innovative point of the invention, one layer of graphene nano layer, graphene nano have been applied above drug delivery layer Layer is using graphene nanometer sheet as base material, with glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy Base silane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R) - Epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- this 6 kinds of material mixings of (trimethyl silicon substrate) trifluoroacetamide form, Middle graphene nanometer sheet is a kind of new material, has good thermal conductivity, while having very in effective ingredient transmission Good effect, in glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus acetic acid first Ester, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino Under t-butyl formate and the mutually coordinated effect of bis- (trimethyl silicon substrate) trifluoroacetamides, middle the effective elements of the medicine can in drug delivery layer Inside of human body is entered faster, the effect of weight-reducing can be played in a short time；Final graphene fat-reducing plaster obtained is not It is only safe to the human body, any side effect will not be generated, and good fat-reducing effect can be played within a short period of time, by reality Verifying, after treatment in 3 months, weight-reducing effective percentage reaches 95% or more, while most of adiposis patient has significantly Effect.
Detailed description of the invention
Fig. 1 is graphene fat-reducing plaster preparation method flow chart.
Specific embodiment
It is described below for disclosing the present invention so that those skilled in the art can be realized the present invention.It is excellent in being described below Embodiment is selected to be only used as illustrating, it may occur to persons skilled in the art that other obvious modifications.
Embodiment 1: a kind of graphene fat-reducing plaster, includes basal layer, drug delivery layer and graphene nano layer, and drug delivery layer is located at Above basal layer, graphene nano layer is located above drug delivery layer；Drug delivery layer includes following parts by weight substance: 35 parts of rheum officinale；Radix Glycyrrhizae 30 parts；25 parts of honeysuckle；22 parts of Pigs Kidney rattan；23 parts of delavay raspberry herb；13 parts of safflower；15 parts of cassia seed；15 parts of dried orange peel；Stir-baked FRUCTUS CRATAEGI 17 Part；15 parts of lotus leaf；8 parts of Jasmine；8 parts of Rhizoma Atractylodis Macrocephalae；6 parts of Poria cocos；6 parts of rhizoma alismatis；6 parts of the tuber of pinellia；7 parts of ginger；5 parts of cassia bark；Aloe 5 Part；4 parts of serissa serissoide；4 parts of Siraitia grosvenorii；4 parts of corn stigma；3 parts of Semen Coicis；1 part of the fleece-flower root；3 parts of honey；2 parts of tea oil.
Graphene nano layer includes following parts by weight material composition:
60 parts of graphene nanometer sheet；
3 parts of ether of glycolic polyoxyethanyl laurel；
5 parts of propyl trimethoxy silicane of 3- (acryloxy)；
3 parts of diethyl phosphorus methyl acetate；
4 parts of ketone of 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4-；
(1S) -1- (2R) -5 parts of t-butyl formate of epoxy ethyl -2- PhenethyIamino；
4 parts of trifluoroacetamide of bis- (trimethyl silicon substrates).
A kind of preparation method of graphene fat-reducing plaster, comprising the following steps:
Step 1: rheum officinale 35g is weighed first；Radix Glycyrrhizae 30g；Honeysuckle 25；Lotus leaf 15g；Jasmine 8g；Rhizoma Atractylodis Macrocephalae 8g；Aloe 5g；Serissa serissoide 4g；Siraitia grosvenorii 4g；Then said medicine is cleaned into drying, is ground after drying, was ground into 120 purposes Fine powder；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times, each 2h altogether, is collected Extracting solution is then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, and is concentrated into 60 DEG C, density is 1.05 Condensed cream one；
Step 3: by Pigs Kidney rattan 22g；Delavay raspberry herb 23g；Safflower 13g；Cassia seed 15g；Dried orange peel 15g；Stir-baked FRUCTUS CRATAEGI 17g；Fu Siberian cocklebur 6g；Rhizoma alismatis 6g；Tuber of pinellia 6g；Ginger 7g；Cassia bark 5g；Corn stigma 4g；Semen Coicis 3g；Fleece-flower root 1g cleans drying and honey 3g, tea Oily 2g is put into togerther in 500ml pure water after immersion 1.5h, and first fast fire is fried open, then pan-fried 60min slowly, then takes out 200ml decocting liquid, 500ml pure water is added, continues pan-fried 60min slowly, takes out 200ml decocting liquid, add 200ml pure water, then pan-fried 120min slowly, it will Decocting liquid is poured out, and is mixed and is stirred evenly with preceding decocting liquid twice；Decocting liquid obtained is concentrated under reduced pressure to the condensed cream for being 1.10 at relative density Two；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: it is prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then according to matching Just by glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino formic acid The tert-butyl ester and 6 kinds of substances of bis- (trimethyl silicon substrate) trifluoroacetamides are added in graphene nanometer sheet, form graphene nano layer；
Step 6: coating ointment made from step 4 on the basal layer made of polyurethane material, ointment with a thickness of 0.5-1 millimeters, alkene nanometer layer of then graphiting on ointment is then sheared, and is modified, and packaging finally obtains graphene Fat-reducing plaster.
Clean drying in step 1 and step 3, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven and dries It is dry, drying time 25min.
Stirring evenly in step 2 is to stir 45min in the case where revolving speed is 700rad/s.
It is extracted in step 2 with ethyl alcohol, is extracted 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, is for the second time 300ml is for the third time 200ml.
Stirring evenly in step 4 refers to that in temperature be 55 DEG C, revolving speed 300rad/s, stirs 2h.
It is by graphene nanometer sheet, glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl front three in step 5 Oxysilane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- (trimethyl silicon substrate) trifluoroacetamides are placed in ultrasound together Sufficiently ultrasound 5 hours in device, graphene nano layer is obtained after ultrasound.
Embodiment 2: a kind of graphene fat-reducing plaster, includes basal layer, drug delivery layer and graphene nano layer, and drug delivery layer is located at Above basal layer, graphene nano layer is located above drug delivery layer；Drug delivery layer includes following parts by weight substance: 40 parts of rheum officinale；Radix Glycyrrhizae 40 parts；40 parts of honeysuckle；30 parts of Pigs Kidney rattan；30 parts of delavay raspberry herb；20 parts of safflower；20 parts of cassia seed；20 parts of dried orange peel；Stir-baked FRUCTUS CRATAEGI 20 Part；20 parts of lotus leaf；10 parts of Jasmine；10 parts of Rhizoma Atractylodis Macrocephalae；10 parts of Poria cocos；10 parts of rhizoma alismatis；10 parts of the tuber of pinellia；10 parts of ginger；10 parts of cassia bark； 10 parts of aloe；5 parts of serissa serissoide；5 parts of Siraitia grosvenorii；5 parts of corn stigma；5 parts of Semen Coicis；2 parts of the fleece-flower root；3 parts of honey；3 parts of tea oil.
Graphene nano layer includes following parts by weight material composition:
60 parts of graphene nanometer sheet；
3 parts of ether of glycolic polyoxyethanyl laurel；
5 parts of propyl trimethoxy silicane of 3- (acryloxy)；
3 parts of diethyl phosphorus methyl acetate；
4 parts of ketone of 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4-；
(1S) -1- (2R) -5 parts of t-butyl formate of epoxy ethyl -2- PhenethyIamino；
4 parts of trifluoroacetamide of bis- (trimethyl silicon substrates).
A kind of preparation method of graphene fat-reducing plaster, comprising the following steps:
Step 1: rheum officinale 40g is weighed first；Radix Glycyrrhizae 40g；Honeysuckle 40g；Lotus leaf 20g；Jasmine 10g；Rhizoma Atractylodis Macrocephalae 10g；Reed Luxuriant growth 10g；Serissa serissoide 5g；Siraitia grosvenorii 5g；Then said medicine is cleaned into drying, is ground after drying, was ground into 120 mesh Fine powder；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times, each 3h altogether, is collected Extracting solution is then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, and is concentrated into 60 DEG C, density is 1.05 Condensed cream one；
Step 3: by Pigs Kidney rattan 30g；Delavay raspberry herb 30g；Safflower 20g；Cassia seed 20g；Dried orange peel 20g；Stir-baked FRUCTUS CRATAEGI 20g；Fu Siberian cocklebur 10g；Rhizoma alismatis 10g；Tuber of pinellia 10g；Ginger 10g；Cassia bark 10g；Corn stigma 5g；Semen Coicis 5g；Fleece-flower root 2g cleans drying and honey 3g, tea oil 3g are put into togerther in 500ml pure water after immersion 2h, and first fast fire is fried open, then pan-fried 60min slowly, and it is pan-fried to then take out 200ml 500ml pure water is added in liquid, and 60min is decocted in continuation slowly, takes out 200ml decocting liquid, adds 200ml pure water, then slow pan-fried 120min pours out decocting liquid, mixes and stirs evenly with preceding decocting liquid twice；It is 1.10 that decocting liquid obtained, which is concentrated under reduced pressure into relative density, Condensed cream two；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: it is prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then according to matching Just by glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino formic acid The tert-butyl ester and 6 kinds of substances of bis- (trimethyl silicon substrate) trifluoroacetamides are added in graphene nanometer sheet, form graphene nano layer；
Step 6: coating ointment made from step 4 on the basal layer made of polyurethane material, ointment with a thickness of 0.5-1 millimeters, alkene nanometer layer of then graphiting on ointment is then sheared, and is modified, and packaging finally obtains graphene Fat-reducing plaster.
Clean drying in step 1 and step 3, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven and dries It is dry, drying time 30min.
Stirring evenly in step 2 is to stir 60min in the case where revolving speed is 800rad/s.
It is extracted in step 2 with ethyl alcohol, is extracted 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, is for the second time 300ml is for the third time 200ml.
Stirring evenly in step 4 refers to that in temperature be 60 DEG C, revolving speed 400rad/s, stirs 2h.
It is by graphene nanometer sheet, glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl front three in step 5 Oxysilane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- (trimethyl silicon substrate) trifluoroacetamides are placed in ultrasound together Sufficiently ultrasound 5 hours in device, graphene nano layer is obtained after ultrasound.
Embodiment 3: a kind of graphene fat-reducing plaster, includes basal layer, drug delivery layer and graphene nano layer, and drug delivery layer is located at Above basal layer, graphene nano layer is located above drug delivery layer；Drug delivery layer includes following parts by weight substance: 20 parts of rheum officinale；Radix Glycyrrhizae 20 parts；20 parts of honeysuckle；20 parts of Pigs Kidney rattan；20 parts of delavay raspberry herb；10 parts of safflower；10 parts of cassia seed；10 parts of dried orange peel；Stir-baked FRUCTUS CRATAEGI 10 Part；10 parts of lotus leaf；5 parts of Jasmine；5 parts of Rhizoma Atractylodis Macrocephalae；5 parts of Poria cocos；5 parts of rhizoma alismatis；5 parts of the tuber of pinellia；5 parts of ginger；5 parts of cassia bark；Aloe 5 Part；3 parts of serissa serissoide；3 parts of Siraitia grosvenorii；3 parts of corn stigma；3 parts of Semen Coicis；1 part of the fleece-flower root；2 parts of honey；2 parts of tea oil.
Graphene nano layer includes following parts by weight material composition:
60 parts of graphene nanometer sheet；
3 parts of ether of glycolic polyoxyethanyl laurel；
5 parts of propyl trimethoxy silicane of 3- (acryloxy)；
3 parts of diethyl phosphorus methyl acetate；
4 parts of ketone of 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4-；
(1S) -1- (2R) -5 parts of t-butyl formate of epoxy ethyl -2- PhenethyIamino；
4 parts of trifluoroacetamide of bis- (trimethyl silicon substrates).
A kind of preparation method of graphene fat-reducing plaster, comprising the following steps:
Step 1: rheum officinale 20g is weighed first；Radix Glycyrrhizae 20g；Honeysuckle 20g；Lotus leaf 10g；Jasmine 5g；Rhizoma Atractylodis Macrocephalae 5g；Aloe 5g；Serissa serissoide 3g；Siraitia grosvenorii 3g；Then said medicine is cleaned into drying, is ground after drying, was ground into 120 purposes Fine powder；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times, each 1-3h altogether, is received Collect extracting solution, is then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density 1.05 Condensed cream one；
Step 3: by Pigs Kidney rattan 20g；Delavay raspberry herb 20g；Safflower 10g；Cassia seed 10g；Dried orange peel 10g；Stir-baked FRUCTUS CRATAEGI 10g；Fu Siberian cocklebur 5g；Rhizoma alismatis 5g；Tuber of pinellia 5g；Ginger 5g；Cassia bark 5g；Corn stigma 3g；Semen Coicis 3g；Fleece-flower root 1g cleans drying and honey 2g, tea Oily 2g is put into togerther in 500ml pure water after immersion 1h, and first fast fire is fried open, then pan-fried 60min slowly, is then taken out 200ml decocting liquid, is added Enter 500ml pure water, continue pan-fried 60min slowly, take out 200ml decocting liquid, add 200ml pure water, then pan-fried 120min slowly, will decoct Liquid is poured out, and is mixed and is stirred evenly with preceding decocting liquid twice；Decocting liquid obtained is concentrated under reduced pressure to the condensed cream two for being 1.10 at relative density；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: it is prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then according to matching Just by glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino formic acid The tert-butyl ester and 6 kinds of substances of bis- (trimethyl silicon substrate) trifluoroacetamides are added in graphene nanometer sheet, form graphene nano layer；
Step 6: coating ointment made from step 4 on the basal layer made of polyurethane material, ointment with a thickness of 0.5-1 millimeters, alkene nanometer layer of then graphiting on ointment is then sheared, and is modified, and packaging finally obtains graphene Fat-reducing plaster.
Clean drying in step 1 and step 3, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven and dries It is dry, drying time 20min.
Stirring evenly in step 2 is to stir 30min in the case where revolving speed is 500rad/s.
It is extracted in step 2 with ethyl alcohol, is extracted 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, is for the second time 300ml is for the third time 200ml.
Stirring evenly in step 4 refers to that in temperature be 50 DEG C, revolving speed 200rad/s, stirs 2h.
It is by graphene nanometer sheet, glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl front three in step 5 Oxysilane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- (trimethyl silicon substrate) trifluoroacetamides are placed in ultrasound together Sufficiently ultrasound 5 hours in device, graphene nano layer is obtained after ultrasound.
Embodiment 4: a kind of graphene fat-reducing plaster, includes basal layer, drug delivery layer and graphene nano layer, and drug delivery layer is located at Above basal layer, graphene nano layer is located above drug delivery layer；Drug delivery layer includes following parts by weight substance: 20 parts of rheum officinale；Radix Glycyrrhizae 20 parts；20 parts of honeysuckle；20 parts of Pigs Kidney rattan；20 parts of delavay raspberry herb；10 parts of safflower；10 parts of cassia seed；10 parts of dried orange peel；Stir-baked FRUCTUS CRATAEGI 10 Part；10 parts of lotus leaf；5 parts of Jasmine；5 parts of Rhizoma Atractylodis Macrocephalae；5 parts of Poria cocos；5 parts of rhizoma alismatis；5 parts of the tuber of pinellia；5 parts of ginger；5 parts of cassia bark；Aloe 5 Part；3 parts of serissa serissoide；3 parts of Siraitia grosvenorii；3 parts of corn stigma；3 parts of Semen Coicis；1 part of the fleece-flower root；2 parts of honey；2 parts of tea oil.
Graphene nano layer includes following parts by weight material composition:
60 parts of graphene nanometer sheet；
3 parts of diethyl phosphorus methyl acetate；
4 parts of ketone of 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4-；
(1S) -1- (2R) -5 parts of t-butyl formate of epoxy ethyl -2- PhenethyIamino；
4 parts of trifluoroacetamide of bis- (trimethyl silicon substrates).
A kind of preparation method of graphene fat-reducing plaster, comprising the following steps:
Step 1: rheum officinale 20g is weighed first；Radix Glycyrrhizae 20g；Honeysuckle 20g；Lotus leaf 10g；Jasmine 5g；Rhizoma Atractylodis Macrocephalae 5g；Aloe 5g；Serissa serissoide 3g；Siraitia grosvenorii 3g；Then said medicine is cleaned into drying, is ground after drying, was ground into 120 purposes Fine powder；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times, each 1-3h altogether, is received Collect extracting solution, is then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density 1.05 Condensed cream one；
Step 3: by Pigs Kidney rattan 20g；Delavay raspberry herb 20g；Safflower 10g；Cassia seed 10g；Dried orange peel 10g；Stir-baked FRUCTUS CRATAEGI 10g；Fu Siberian cocklebur 5g；Rhizoma alismatis 5g；Tuber of pinellia 5g；Ginger 5g；Cassia bark 5g；Corn stigma 3g；Semen Coicis 3g；Fleece-flower root 1g cleans drying and honey 2g, tea Oily 2g is put into togerther in 500ml pure water after immersion 1h, and first fast fire is fried open, then pan-fried 60min slowly, is then taken out 200ml decocting liquid, is added Enter 500ml pure water, continue pan-fried 60min slowly, take out 200ml decocting liquid, add 200ml pure water, then pan-fried 120min slowly, will decoct Liquid is poured out, and is mixed and is stirred evenly with preceding decocting liquid twice；Decocting liquid obtained is concentrated under reduced pressure to the condensed cream two for being 1.10 at relative density；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: it is prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then according to matching Just by diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-ring Oxygen ethyl -2- PhenethyIamino t-butyl formate and 4 kinds of substances of bis- (trimethyl silicon substrate) trifluoroacetamides are added to graphene and receive In rice piece, graphene nano layer is formed；
Step 6: coating ointment made from step 4 on the basal layer made of polyurethane material, ointment with a thickness of 0.5-1 millimeters, alkene nanometer layer of then graphiting on ointment is then sheared, and is modified, and packaging finally obtains graphene Fat-reducing plaster.
Clean drying in step 1 and step 3, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven and dries It is dry, drying time 20min.
Stirring evenly in step 2 is to stir 30min in the case where revolving speed is 500rad/s.
It is extracted in step 2 with ethyl alcohol, is extracted 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, is for the second time 300ml is for the third time 200ml.
Stirring evenly in step 4 refers to that in temperature be 50 DEG C, revolving speed 200rad/s, stirs 2h.
It is by graphene nanometer sheet, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- in step 5 Phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- (trimethyl silicon substrate) trifluoros Acetamide is placed in Vltrasonic device sufficiently ultrasound 5 hours together, obtains graphene nano layer after ultrasound.
Embodiment 5: a kind of graphene fat-reducing plaster, includes basal layer, drug delivery layer and graphene nano layer, and drug delivery layer is located at Above basal layer, graphene nano layer is located above drug delivery layer；Drug delivery layer includes following parts by weight substance: 20 parts of rheum officinale；Radix Glycyrrhizae 20 parts；20 parts of honeysuckle；20 parts of Pigs Kidney rattan；20 parts of delavay raspberry herb；10 parts of safflower；10 parts of cassia seed；10 parts of dried orange peel；Stir-baked FRUCTUS CRATAEGI 10 Part；10 parts of lotus leaf；5 parts of Jasmine；5 parts of Rhizoma Atractylodis Macrocephalae；5 parts of Poria cocos；5 parts of rhizoma alismatis；5 parts of the tuber of pinellia；5 parts of ginger；5 parts of cassia bark；Aloe 5 Part；3 parts of serissa serissoide；3 parts of Siraitia grosvenorii；3 parts of corn stigma；3 parts of Semen Coicis；1 part of the fleece-flower root；2 parts of honey；2 parts of tea oil.
Graphene nano layer includes following parts by weight material composition:
60 parts of graphene nanometer sheet；
3 parts of ether of glycolic polyoxyethanyl laurel；
5 parts of propyl trimethoxy silicane of 3- (acryloxy)；
(1S) -1- (2R) -5 parts of t-butyl formate of epoxy ethyl -2- PhenethyIamino；
4 parts of trifluoroacetamide of bis- (trimethyl silicon substrates).
A kind of preparation method of graphene fat-reducing plaster, comprising the following steps:
Step 1: rheum officinale 20g is weighed first；Radix Glycyrrhizae 20g；Honeysuckle 20g；Lotus leaf 10g；Jasmine 5g；Rhizoma Atractylodis Macrocephalae 5g；Aloe 5g；Serissa serissoide 3g；Siraitia grosvenorii 3g；Then said medicine is cleaned into drying, is ground after drying, was ground into 120 purposes Fine powder；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times, each 1-3h altogether, is received Collect extracting solution, is then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density 1.05 Condensed cream one；
Step 3: by Pigs Kidney rattan 20g；Delavay raspberry herb 20g；Safflower 10g；Cassia seed 10g；Dried orange peel 10g；Stir-baked FRUCTUS CRATAEGI 10g；Fu Siberian cocklebur 5g；Rhizoma alismatis 5g；Tuber of pinellia 5g；Ginger 5g；Cassia bark 5g；Corn stigma 3g；Semen Coicis 3g；Fleece-flower root 1g cleans drying and honey 2g, tea Oily 2g is put into togerther in 500ml pure water after immersion 1h, and first fast fire is fried open, then pan-fried 60min slowly, is then taken out 200ml decocting liquid, is added Enter 500ml pure water, continue pan-fried 60min slowly, take out 200ml decocting liquid, add 200ml pure water, then pan-fried 120min slowly, will decoct Liquid is poured out, and is mixed and is stirred evenly with preceding decocting liquid twice；Decocting liquid obtained is concentrated under reduced pressure to the condensed cream two for being 1.10 at relative density；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: it is prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then according to matching Just by glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, (1S) -1- (2R)-epoxy ethyl - 2- PhenethyIamino t-butyl formate and 4 kinds of substances of bis- (trimethyl silicon substrate) trifluoroacetamides are added in graphene nanometer sheet, Form graphene nano layer；
Step 6: coating ointment made from step 4 on the basal layer made of polyurethane material, ointment with a thickness of 0.5-1 millimeters, alkene nanometer layer of then graphiting on ointment is then sheared, and is modified, and packaging finally obtains graphene Fat-reducing plaster.
Clean drying in step 1 and step 3, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven and dries It is dry, drying time 20min.
Stirring evenly in step 2 is to stir 30min in the case where revolving speed is 500rad/s.
It is extracted in step 2 with ethyl alcohol, is extracted 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, is for the second time 300ml is for the third time 200ml.
Stirring evenly in step 4 refers to that in temperature be 50 DEG C, revolving speed 200rad/s, stirs 2h.
It is by graphene nanometer sheet, glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl front three in step 5 Oxysilane, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- (trimethyl silicon substrate) trifluoroacetyls Amine is placed in Vltrasonic device sufficiently ultrasound 5 hours together, obtains graphene nano layer after ultrasound.
Embodiment 6: a kind of graphene fat-reducing plaster, includes basal layer, drug delivery layer and graphene nano layer, and drug delivery layer is located at Above basal layer, graphene nano layer is located above drug delivery layer；Drug delivery layer includes following parts by weight substance: 20 parts of rheum officinale；Radix Glycyrrhizae 20 parts；20 parts of honeysuckle；20 parts of Pigs Kidney rattan；20 parts of delavay raspberry herb；10 parts of safflower；10 parts of cassia seed；10 parts of dried orange peel；Stir-baked FRUCTUS CRATAEGI 10 Part；10 parts of lotus leaf；5 parts of Jasmine；5 parts of Rhizoma Atractylodis Macrocephalae；5 parts of Poria cocos；5 parts of rhizoma alismatis；5 parts of the tuber of pinellia；5 parts of ginger；5 parts of cassia bark；Aloe 5 Part；3 parts of serissa serissoide；3 parts of Siraitia grosvenorii；3 parts of corn stigma；3 parts of Semen Coicis；1 part of the fleece-flower root；2 parts of honey；2 parts of tea oil.
Graphene nano layer includes following parts by weight material composition:
60 parts of graphene nanometer sheet；
3 parts of ether of glycolic polyoxyethanyl laurel；
5 parts of propyl trimethoxy silicane of 3- (acryloxy)；
3 parts of diethyl phosphorus methyl acetate；
4 parts of ketone of 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4-.
A kind of preparation method of graphene fat-reducing plaster, comprising the following steps:
Step 1: rheum officinale 20g is weighed first；Radix Glycyrrhizae 20g；Honeysuckle 20g；Lotus leaf 10g；Jasmine 5g；Rhizoma Atractylodis Macrocephalae 5g；Aloe 5g；Serissa serissoide 3g；Siraitia grosvenorii 3g；Then said medicine is cleaned into drying, is ground after drying, was ground into 120 purposes Fine powder；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times, each 1-3h altogether, is received Collect extracting solution, is then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density 1.05 Condensed cream one；
Step 3: by Pigs Kidney rattan 20g；Delavay raspberry herb 20g；Safflower 10g；Cassia seed 10g；Dried orange peel 10g；Stir-baked FRUCTUS CRATAEGI 10g；Fu Siberian cocklebur 5g；Rhizoma alismatis 5g；Tuber of pinellia 5g；Ginger 5g；Cassia bark 5g；Corn stigma 3g；Semen Coicis 3g；Fleece-flower root 1g cleans drying and honey 2g, tea Oily 2g is put into togerther in 500ml pure water after immersion 1h, and first fast fire is fried open, then pan-fried 60min slowly, is then taken out 200ml decocting liquid, is added Enter 500ml pure water, continue pan-fried 60min slowly, take out 200ml decocting liquid, add 200ml pure water, then pan-fried 120min slowly, will decoct Liquid is poured out, and is mixed and is stirred evenly with preceding decocting liquid twice；Decocting liquid obtained is concentrated under reduced pressure to the condensed cream two for being 1.10 at relative density；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: it is prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then according to matching Just by glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1, this 4 kinds of substances of 2,3- phentriazine -4- ketone are added in graphene nanometer sheet, form graphite Alkene nanometer layer；
Step 6: coating ointment made from step 4 on the basal layer made of polyurethane material, ointment with a thickness of 0.5-1 millimeters, alkene nanometer layer of then graphiting on ointment is then sheared, and is modified, and packaging finally obtains graphene Fat-reducing plaster.
Clean drying in step 1 and step 3, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven and dries It is dry, drying time 20min.
Stirring evenly in step 2 is to stir 30min in the case where revolving speed is 500rad/s.
It is extracted in step 2 with ethyl alcohol, is extracted 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, is for the second time 300ml is for the third time 200ml.
Stirring evenly in step 4 refers to that in temperature be 50 DEG C, revolving speed 200rad/s, stirs 2h.
It is by graphene nanometer sheet, glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl front three in step 5 Oxysilane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone are placed in together Sufficiently ultrasound 5 hours in Vltrasonic device, graphene nano layer is obtained after ultrasound.
Comparative example 1: application No. is the Chinese patents of CN200310100375.7 --- fat-reducing plaster,.
Detect curative effect: by fat-reducing plaster sample made from graphene fat-reducing plaster sample made from embodiment 1-6 and comparative example 1
It is attached on the navel of adiposis patient, twice a day, each duration is 2 hours, each sample is 60 corresponding Adiposis patient, curative effect are divided into effective, effectively, invalid three kinds, curative effect are observed after 3 months；It observes and is lost weight using each sample simultaneously After patch, there is the probability of the side reactions such as slight abdominal pain, dizziness, out of strength, drowsiness in adiposis patient.
There is the probability of side reaction in adiposis patient:
Sample Occur side reaction probability (%)
Embodiment 1 0
Embodiment 2 0
Embodiment 3 0
Embodiment 4 0
Embodiment 5 0
Embodiment 6 0
Comparative example 1 0
By above-mentioned chart it is found that used the adiposis patient of each sample fat-reducing plaster do not have an example occur slight abdominal pain, dizziness, The side reactions such as out of strength, drowsiness, illustrate above-mentioned each sample be to human body it is very safe, side effect will not be generated, can ensure people Body health, and can be carried out weight-reducing.
Curative effect on obesity:
As above-mentioned chart it is found that the total effective rate of fat-reducing plaster made from embodiment 1-6 and comparative example 1 all reaches 90 or more, Especially fat-reducing plaster effective percentage made from embodiment 1 reaches 98 or more, to illustrate that the fat-reducing plaster has weight-reducing effect well Fruit；Simultaneously compared with comparative example 1, the fat-reducing effect of sample made from embodiment 1-6 is more preferable, especially embodiment 1, there is significant effect The probability of fruit has reached 66.67%, illustrates after using the fat-reducing plaster 3 months, generally just has very much good fat-reducing effect, institute It takes time shorter, is easier to be received by adiposis patient.
A kind of graphene fat-reducing plaster of the invention, includes basal layer, drug delivery layer and graphene nano layer, wherein basal layer It is made of polyurethane material, and using rheum officinale, Radix Glycyrrhizae, honeysuckle as main ingredient in drug delivery layer, rheum officinale, which has, promotes enterocinesia, inhibits Enteral moisture absorption promotes defecation and other effects, and Radix Glycyrrhizae has polishing, clearing heat and detoxicating effect, and honeysuckle has removing summer-heat blood poison, increases The effect of strong immunity, can not only promote adiposis patient to accelerate enterocinesia under this 3 kinds of Chinese medicine collective effects, various poison are discharged Element has good fat-reducing effect to adiposis patient, and can be improved the immunity of adiposis patient, ensures the strong of adiposis patient Health；And it can further be mentioned under Pigs Kidney rattan, delavay raspberry herb, safflower, cassia seed, stir-baked FRUCTUS CRATAEGI and lotus leaf this 6 kinds of Chinese medicine collective effects High fat-reducing effect enables fat-reducing plaster produced by the present invention just to have good fat-reducing effect in a relatively short period of time, so that fertile Fat patient's quick weight-lossing, stature of getting well；Due to using Radix Glycyrrhizae to be easy to cause the side reactions such as patient's indigestion；Pass through addition Dried orange peel, Jasmine, Rhizoma Atractylodis Macrocephalae, Poria cocos, rhizoma alismatis, the tuber of pinellia, ginger and cassia bark can not only remove under the interaction of this 8 taste Chinese medicine Because the side reaction of Radix Glycyrrhizae bring is added, guarantee that the drug paste can promote patient to drug to the safety of adiposis patient, while also It absorbs, accelerates the weight-reducing speed of patient；Also added aloe, serissa serissoide, Siraitia grosvenorii, corn stigma, Semen Coicis, the fleece-flower root, honey and Tea oil under this 8 kinds of Chinese medicine collective effects, can not only greatly improve the body immunity of adiposis patient, while can also play " profit The effect of cunning ", enables the pharmacological property of each Chinese medicine to bring into play completely, ensure that the fat-reducing plaster has good fat-reducing effect.
As another innovative point of the invention, one layer of graphene nano layer, graphene nano have been applied above drug delivery layer Layer is using graphene nanometer sheet as base material, with glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy Base silane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R) - Epoxy ethyl -2- PhenethyIamino t-butyl formate and bis- this 6 kinds of material mixings of (trimethyl silicon substrate) trifluoroacetamide form, Middle graphene nanometer sheet is a kind of new material, has good thermal conductivity, while having very in effective ingredient transmission Good effect, in glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus acetic acid first Ester, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino Under t-butyl formate and the mutually coordinated effect of bis- (trimethyl silicon substrate) trifluoroacetamides, middle the effective elements of the medicine can in drug delivery layer Inside of human body is entered faster, the effect of weight-reducing can be played in a short time；Final graphene fat-reducing plaster obtained is not It is only safe to the human body, any side effect will not be generated, and good fat-reducing effect can be played within a short period of time, by reality Verifying, after treatment in 3 months, weight-reducing effective percentage reaches 95% or more, while most of adiposis patient has significantly Effect.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its Equivalent defines.

Claims (9)

1. a kind of graphene fat-reducing plaster, it is characterised in that: include basal layer, drug delivery layer and graphene nano layer, drug delivery layer position Above basal layer, graphene nano layer is located above drug delivery layer；Drug delivery layer includes following parts by weight substance: 20-40 parts of rheum officinale； 20-40 parts of Radix Glycyrrhizae；20-40 parts of honeysuckle；20-30 parts of Pigs Kidney rattan；20-30 parts of delavay raspberry herb；10-20 parts of safflower；Cassia seed 10- 20 parts；10-20 parts of dried orange peel；10-20 parts of stir-baked FRUCTUS CRATAEGI；10-20 parts of lotus leaf；5-10 parts of Jasmine；5-10 parts of Rhizoma Atractylodis Macrocephalae；Poria cocos 5-10 Part；5-10 parts of rhizoma alismatis；5-10 parts of the tuber of pinellia；5-10 parts of ginger；5-10 parts of cassia bark；5-10 parts of aloe；3-5 parts of serissa serissoide；Siraitia grosvenorii 3-5 parts；3-5 parts of corn stigma；3-5 parts of Semen Coicis；1-2 parts of the fleece-flower root；2-3 parts of honey；2-3 parts of tea oil.
2. a kind of graphene fat-reducing plaster according to claim 1, it is characterised in that: preferably, drug delivery layer includes following weight Part substance: 35 parts of rheum officinale；30 parts of Radix Glycyrrhizae；25 parts of honeysuckle；22 parts of Pigs Kidney rattan；23 parts of delavay raspberry herb；13 parts of safflower；Cassia seed 15 Part；15 parts of dried orange peel；17 parts of stir-baked FRUCTUS CRATAEGI；15 parts of lotus leaf；8 parts of Jasmine；8 parts of Rhizoma Atractylodis Macrocephalae；6 parts of Poria cocos；6 parts of rhizoma alismatis；6 parts of the tuber of pinellia；It is raw 7 parts of ginger；5 parts of cassia bark；5 parts of aloe；4 parts of serissa serissoide；4 parts of Siraitia grosvenorii；4 parts of corn stigma；3 parts of Semen Coicis；1 part of the fleece-flower root；Honey 3 Part；2 parts of tea oil.
3. a kind of graphene fat-reducing plaster according to claim 1 or 2, it is characterised in that: graphene nano layer includes following weight Part material composition:
60 parts of graphene nanometer sheet；
3 parts of ether of glycolic polyoxyethanyl laurel；
5 parts of propyl trimethoxy silicane of 3- (acryloxy)；
3 parts of diethyl phosphorus methyl acetate；
4 parts of ketone of 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4-；
(1S) -1- (2R) -5 parts of t-butyl formate of epoxy ethyl -2- PhenethyIamino；
4 parts of trifluoroacetamide of bis- (trimethyl silicon substrates).
4. a kind of preparation method of graphene fat-reducing plaster, it is characterised in that: the following steps are included:
Step 1: rheum officinale 20-40g is weighed first；Radix Glycyrrhizae 20-40g；Honeysuckle 20-40g；Lotus leaf 10-20g；Jasmine 5-10g； Rhizoma Atractylodis Macrocephalae 5-10g；Aloe 5-10g；Serissa serissoide 3-5g；Siraitia grosvenorii 3-5g；Then said medicine is cleaned into drying, is carried out after drying Grinding, was ground into 120 targeted fine powders；
Step 2: above-mentioned traditional Chinese medicine fine powder being stirred evenly, is then extracted with ethyl alcohol, is extracted 3 times altogether, each 1-3h, collection mentions Take liquid, be then allowed to stand for 24 hours, supernatant is then obtained by filtration, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density be 1.05 it is dense Contracting cream one；
Step 3: by Pigs Kidney rattan 20-30g；Delavay raspberry herb 20-30g；Safflower 10-20g；Cassia seed 10-20g；Dried orange peel 10-20g； Stir-baked FRUCTUS CRATAEGI 10-20g；Poria cocos 5-10g；Rhizoma alismatis 5-10g；Tuber of pinellia 5-10g；Ginger 5-10g；Cassia bark 5-10g；Corn stigma 3-5g；The heart of a lotus seed Rice 3-5g；Fleece-flower root 1-2g cleans drying and honey 2-3g, tea oil 2-3g are put into togerther after impregnating 1-2h in 500ml pure water, First fast fire is fried open, then pan-fried 60min slowly, then takes out 200ml decocting liquid, 500ml pure water is added, and is continued pan-fried 60min slowly, is taken out 200ml decocting liquid adds 200ml pure water, then pan-fried 120min slowly, and decocting liquid is poured out, mixes and stirs evenly with preceding decocting liquid twice；It will The condensed cream two that it is 1.10 at relative density that decocting liquid obtained, which is concentrated under reduced pressure,；
Step 4: condensed cream one and condensed cream two are stirred evenly, ointment needed for drug delivery layer；
Step 5: being prepared using chemical vapor deposition hair with a thickness of 100-200nm graphene nanometer sheet, then will according to formula Glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus methyl acetate, 3- (diethyl Oxygroup phosphinylidyne oxygroup) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino t-butyl formate It is added in graphene nanometer sheet with 6 kinds of substances of bis- (trimethyl silicon substrate) trifluoroacetamides, forms graphene nano layer；
Step 6: ointment made from step 4 is coated on the basal layer made of polyurethane material, ointment is with a thickness of 0.5-1 milli Rice, alkene nanometer layer of then graphiting on ointment are then sheared, and are modified, and packaging finally obtains graphene fat-reducing plaster.
5. a kind of preparation method of graphene fat-reducing plaster according to claim 4, it is characterised in that: in step 1 and step 3 Clean drying, which is each meant, first washes away sundries with clear water, is then placed in 60 DEG C of baking oven drying, drying time 20-30min.
6. a kind of preparation method of graphene fat-reducing plaster according to claim 5, it is characterised in that: stirring evenly in step 2 It is to stir 30-60min in the case where revolving speed is 500-800rad/s.
7. a kind of preparation method of graphene fat-reducing plaster according to claim 6, it is characterised in that: mentioned in step 2 with ethyl alcohol It takes, extracts 3 times altogether, the usage amount of first time ethyl alcohol is 300ml, and it is for the third time 200ml that second, which is 300ml,.
8. a kind of preparation method of graphene fat-reducing plaster according to claim 7, it is characterised in that: stirring evenly in step 4 Refer to that in temperature be 50-60 DEG C, revolving speed 200-400rad/s, stirs 2h.
9. a kind of preparation method of graphene fat-reducing plaster according to claim 8, it is characterised in that: be by graphene in step 5 Nanometer sheet, glycolic polyoxyethanyl laurel ether, 3- (acryloxy) propyl trimethoxy silicane, diethyl phosphorus methyl acetate, 3- (diethoxy phosphoryl oxy) -1,2,3- phentriazine -4- ketone, (1S) -1- (2R)-epoxy ethyl -2- PhenethyIamino first Tert-butyl acrylate and bis- (trimethyl silicon substrate) trifluoroacetamides are placed in Vltrasonic device sufficiently ultrasound 5 hours together, and ultrasound terminates After obtain graphene nano layer.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110522636A (en) * 2019-09-25 2019-12-03 上海璟沁生物科技有限公司 A kind of moxibustion plaster and its application method

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