CN109172781A - A kind of Chinese medicine composition for treating hepatitis B, cirrhosis - Google Patents
A kind of Chinese medicine composition for treating hepatitis B, cirrhosis Download PDFInfo
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- CN109172781A CN109172781A CN201811399406.6A CN201811399406A CN109172781A CN 109172781 A CN109172781 A CN 109172781A CN 201811399406 A CN201811399406 A CN 201811399406A CN 109172781 A CN109172781 A CN 109172781A
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Abstract
The present invention relates to a kind of herbal composites, more particularly to a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, be made of following raw material: ginseng, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix paeoniae rubra, Radix Salviae Miltiorrhizae, trigone, curcuma zedoary, Eupolyphoge sinensis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, motherwort, polygonum cuspidate, leech, oldenlandia diffusa, Radix Isatidis, oriental wormwood, Charred Triplet be each, radish seed, Schisandra chinensis, radix bupleuri, rabdosia lophanthide, stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, dried orange peel, green peel, dried human placenta.The present invention meets Chinese medical discrimination theory in Chinese medicine selection and compatibility, and preparation method is simple, be made after compatibility water decoction or it is other be suitable for the medicament taken, to acute and chronic hepatitis B inflammation, hepatitis B big and small three Yang, hepatitis, cirrhosis, liver ascites, hepatosplenomegaly, Laennec's cirrhosis, alcoholic liver, and good effect, it is quick, treating both manifestation and root cause of disease, and have no toxic side effect, reach complementary purpose in drug matching.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for treating hepatitis B, cirrhosis.
Background technique
Hbv-liver cirrhosis is mostly a kind of common chronic liver disease, by hepatitis B long-term damage by obtaining after hepatitis B hepatitis
Liver causes, and liver is in progressive, diffusivity, fibrous lesions.Cirrhosis clinic is based on liver function damage and portal hypertension
It shows.I thinks that liver qi and blood is retarded by silt according to theory of traditional Chinese medical science, channels and collaterals occlusion, body fluid cannot defeated cloth with nutrition liver, liver
Dystrophy, therefore cirrhosis form crux, therefore occur: diet reduction, indigestion, abdominal distention after meal, nausea, tired spirit, syntexis, the heart
Refreshing uneasiness, insomnia, both sides of the chest distending pain, liver palm, jaundice, urine are yellow.It is abnormal to chemically examine liver function, hepatitis B virus positive, it is swollen that B surpasses liver
Greatly, liver surface is rough, and liver parenchyma Echoenhance, coarse unshapeliness, portal vein diameter is broadening, splenomegaly.I am after 30
Clinical research discovery in several years, treatment hepatitis B, cirrhosis answer antiviral, dredging the channel, nourish body fluid nutrition liver, and liver obtains
It supports, cirrhosis is regarded for oneself.Treat cirrhosis Chinese medicine from thus so far be mostly used soothing liver-qi stagnation, clearing heat and detoxicating, promoting blood circulation, resolving hard lump,
Clearing heat and promoting diuresis drug take in addition Western medicine anti-hepatitis virus drug therapy it, such as: radix bupleuri, Radix Curcumae, Fructus Forsythiae, safflower, peach kernel, cream
Perfume, myrrh, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Notoginseng, fructus lycii, Radix Angelicae Sinensis, turtle shell, keel, oyster, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, Xiaoyao San (office
Side), the shortcomings that these drugs such as Gexia Zhuyu Tang (correction of the errors of medical works) have therapeutic effect, cut down liver, this be ancient times always till now
Chinese traditional treatment cirrhosis abides by suitable principle of reatment, although this principle of reatment is effectively, effect is undesirable, has cure rate
It is low, slow disadvantage is cured, cirrhosis can not be effectively cured.Modern medicine is mainly antiviral therapy to hbv-liver cirrhosis
It, if not, then liver protection of being infused, with vitamin K1 injection, reduced glutathione, dimension life is added in 5% glucose injection
Plain C, potassium chloride etc., or input albumin, fresh plasma.Silybin Capsules for oral administration, Anethol Trithione etc. in the liver that disappears inflammation with
Normalizing gallbladder to cure jaundice, but its effect is undesirable, cures slowly, cure rate is low.And Western medicine is largely all chemical synthesis, and has secondary work
With due to largely using Western medicine, cirrhosis is not cured.
Summary of the invention
The purpose of the present invention is to provide a kind of cheap, curative effect is fast, and treatment hepatitis B, cirrhosis effect are good, cure rate
High Chinese medicine composition.
In order to achieve the above object, the present invention is achieved through the following technical solutions:
The raw material composition and ratio of a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, the Chinese medicine composition are as follows: ginseng
10-30 parts, 30-60 parts of Radix Astragali, 30-60 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of Poria cocos, 15-30 parts of radix paeoniae rubra, Radix Salviae Miltiorrhizae 15-30
Part, 10-18 parts of trigone, 10-18 parts of curcuma zedoary, 6-15 parts of Eupolyphoge sinensis, 10-15 parts of Rhizoma Chuanxiong, 10-20 parts of Radix Angelicae Sinensis, benefit are female
15-30 parts careless, 10-30 parts of polygonum cuspidate, 6-10 parts of leech, 15-30 parts of oldenlandia diffusa, 10-30 parts of Radix Isatidis, mattress
It is 10-30 parts old, Charred Triplet is 15-30 parts each, 10-20 parts of radish seed, 10-30 parts of Schisandra chinensis, 9-15 parts of radix bupleuri, small stream
15-30 parts of yellow grass, 15-30 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 10-15 parts of dried orange peel, 10-15 parts of green peel, 5-15 parts of dried human placenta.
Preferably, the raw material composition and ratio of the Chinese medicine composition are as follows: 20 parts of ginseng, 45 parts of Radix Astragali, Rhizoma Atractylodis Macrocephalae
45 parts, 15 parts of Poria cocos, 22 parts of radix paeoniae rubra, 23 parts of Radix Salviae Miltiorrhizae, 14 parts of trigone, 14 parts of curcuma zedoary, 11 parts of Eupolyphoge sinensis, Rhizoma Chuanxiong
12.5 parts, 15 parts of Radix Angelicae Sinensis, 22 parts of motherwort, 20 parts of polygonum cuspidate, 8 parts of leech, 22 parts of oldenlandia diffusa, Radix Isatidis
20 parts, 20 parts of oriental wormwood, Charred Triplet be 22 parts each, 15 parts of radish seed, 20 parts of Schisandra chinensis, 12.5 parts of radix bupleuri, rabdosia lophanthide
22 parts, 22 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 12.5 parts of dried orange peel, 12.5 parts of green peel, 10 parts of dried human placenta.
Preferably, the Chinese medicine composition is that bulk pharmaceutical chemicals press pharmacy conventional method, is added or is added without auxiliary material to be used, make
At clinically acceptable dosage form.
Preferably, the dosage form can be powder, granule, capsule, tablet, oral liquid.
The present invention also provides above-mentioned treatment hepatitis B, the preparation method of the Chinese medicine composition of cirrhosis, it includes following step
It is rapid: (1) to weigh bulk pharmaceutical chemicals according to the ratio, put it into casserole, the dipped powder 2-4cm of clear water is added, and impregnate 10-20min；
(2) first the bulk pharmaceutical chemicals being immersed in casserole clear water are boiled with high heat, are changed to be cooked by slow fire 20-30min later,
It is spare after leaching decocting liquid；
(3) remaining filter residue will be filtered successively according to the operating method of step (1) and step (2) in step (2), again into
Row processing, filters to take decocting liquid, spare；
(4) mixing the decocting liquid obtained in step (2) and step (3) and being concentrated into relative density is 1.20-1.30, stirring condition
Under, it is slowly added into the 90%v/v ethanol solution of 2 times of amounts, is stirred, is stood, filtering, filtrate low-temperature evaporation is concentrated into relatively close
Degree is 1.40-1.50, and recycles ethyl alcohol, obtains concentrate；
(5) water and auxiliaries are added to be spray-dried at decoction, or by concentrate concentrate, capsule, piece is made in addition auxiliary material
Agent, pill, granule.
Preferably, in step (4), the mixing time is 18-25 minutes, and time of repose is 35-55 hours.
Preferably, in step (4), spray drying condition are as follows: inlet air temperature is 110-120 DEG C, outlet temperature 75-
85 DEG C, temperature of charge is 50-60 DEG C, atomizing pressure 0.5-0.7MPa, spray velocity 4-8ml/s.
The present invention compared with prior art, with following the utility model has the advantages that
The present invention meets Chinese medical discrimination theory in Chinese medicine selection and compatibility, and preparation method is simple, and decocting is made after compatibility
Agent or it is other be suitable for the medicament taken, to acute and chronic hepatitis B inflammation, hepatitis B big and small three Yang, hepatitis, cirrhosis, liver ascites, liver and spleen is swollen
Greatly, Laennec's cirrhosis, alcoholic liver, and good effect, quick, treating both manifestation and root cause of disease, and have no toxic side effect, reach in drug matching
Complementary purpose.
Specific embodiment
By the following examples form, above content of the invention is described in further detail again but should not be by this
The range for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiment, all technologies based on realization belonging to above content of the present invention
It all belongs to the scope of the present invention.
Embodiment 1
The raw material composition and ratio of a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, the Chinese medicine composition are as follows: ginseng
10 parts, 30 parts of Radix Astragali, 30 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 15 parts of radix paeoniae rubra, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of trigone, curcuma zedoary
10 parts, 6 parts of Eupolyphoge sinensis, 10 parts of Rhizoma Chuanxiong, 10 parts of Radix Angelicae Sinensis, 15 parts of motherwort, 10 parts of polygonum cuspidate, 6 parts of leech, white flower
15 parts of HERBA HEDYOTIS DIFFUSAE, 10 parts of Radix Isatidis, 10 parts of oriental wormwood, Charred Triplet be 15 parts each, 10 parts of radish seed, Schisandra chinensis 10
Part, 9 parts of radix bupleuri, 15 parts of rabdosia lophanthide, 15 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 10 parts of dried orange peel, 10 parts of green peel, 5 parts of dried human placenta.
Wherein, the Chinese medicine composition is that bulk pharmaceutical chemicals press pharmacy conventional method, is added or is added without auxiliary material to be used, be made
Clinically acceptable dosage form.
Wherein, the dosage form can be powder, granule, capsule, tablet, oral liquid.
The present invention also provides above-mentioned treatment hepatitis B, the preparation method of the Chinese medicine composition of cirrhosis, it includes following step
It is rapid: (1) to weigh bulk pharmaceutical chemicals according to the ratio, put it into casserole, the dipped powder 2cm of clear water is added, and impregnate 10-20min；
(2) first the bulk pharmaceutical chemicals being immersed in casserole clear water are boiled with high heat, is changed to be cooked by slow fire 20min later, then
Decocting liquid is filtered to take, it is spare；
(3) remaining filter residue will be filtered successively according to the operating method of step (1) and step (2) in step (2), again into
Row processing, filters to take decocting liquid, spare；
(4) mixing the decocting liquid obtained in step (2) and step (3) and being concentrated into relative density is 1.20, under stirring condition, is delayed
The slow 90%v/v ethanol solution that 2 times of amounts are added, is stirred, and is stood, and filtering, filtrate low-temperature evaporation is concentrated into relative density and is
1.40, and ethyl alcohol is recycled, obtain concentrate；
(5) water and auxiliaries are added to be spray-dried at decoction, or by concentrate concentrate, capsule, piece is made in addition auxiliary material
Agent, pill, granule.
Wherein, in step (4), the mixing time is 18 minutes, and time of repose is 35 hours.
Wherein, in step (4), spray drying condition are as follows: inlet air temperature is 110 DEG C, and outlet temperature is 75 DEG C, material
Temperature is 50 DEG C, atomizing pressure 0.5MPa, spray velocity 4ml/s.
Embodiment 2
The raw material composition and ratio of a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, the Chinese medicine composition are as follows: people
Join 30 parts, 60 parts of Radix Astragali, 60 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Poria cocos, 30 parts of radix paeoniae rubra, 30 parts of Radix Salviae Miltiorrhizae, trigone 18
Part, 18 parts of curcuma zedoary, 15 parts of Eupolyphoge sinensis, 15 parts of Rhizoma Chuanxiong, 20 parts of Radix Angelicae Sinensis, 30 parts of motherwort, 30 parts of polygonum cuspidate, leech
10 parts, 30 parts of oldenlandia diffusa, 30 parts of Radix Isatidis, 30 parts of oriental wormwood, Charred Triplet be 30 parts each, 20 parts of radish seed, five
30 parts of taste, 15 parts of radix bupleuri, 30 parts of rabdosia lophanthide, 30 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 15 parts of dried orange peel, 15 parts of green peel, dried human placenta
15 parts.
Wherein, the Chinese medicine composition is that bulk pharmaceutical chemicals press pharmacy conventional method, is added or is added without auxiliary material to be used, be made
Clinically acceptable dosage form.
Wherein, the dosage form can be powder, granule, capsule, tablet, oral liquid.
The present invention also provides above-mentioned treatment hepatitis B, the preparation method of the Chinese medicine composition of cirrhosis, it includes following step
It is rapid: (1) to weigh bulk pharmaceutical chemicals according to the ratio, put it into casserole, the dipped powder 2-4cm of clear water is added, and impregnate 20min；
(2) first the bulk pharmaceutical chemicals being immersed in casserole clear water are boiled with high heat, is changed to be cooked by slow fire 30min later, then
Decocting liquid is filtered to take, it is spare；
(3) remaining filter residue will be filtered successively according to the operating method of step (1) and step (2) in step (2), again into
Row processing, filters to take decocting liquid, spare；
(4) mixing the decocting liquid obtained in step (2) and step (3) and being concentrated into relative density is 1.30, under stirring condition, is delayed
The slow 90%v/v ethanol solution that 2 times of amounts are added, is stirred, and is stood, and filtering, filtrate low-temperature evaporation is concentrated into relative density and is
1.50, and ethyl alcohol is recycled, obtain concentrate；
(5) water and auxiliaries are added to be spray-dried at decoction, or by concentrate concentrate, capsule, piece is made in addition auxiliary material
Agent, pill, granule.
Wherein, in step (4), the mixing time is 25 minutes, and time of repose is 55 hours.
Wherein, in step (4), spray drying condition are as follows: inlet air temperature is 120 DEG C, and outlet temperature is 85 DEG C, material
Temperature is 60 DEG C, atomizing pressure 0.7MPa, spray velocity 8ml/s.
Embodiment 3
The raw material composition and ratio of a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, the Chinese medicine composition are as follows: ginseng
20 parts, 45 parts of Radix Astragali, 45 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 22 parts of radix paeoniae rubra, 23 parts of Radix Salviae Miltiorrhizae, 14 parts of trigone, curcuma zedoary
14 parts, it is 11 parts of Eupolyphoge sinensis, 12.5 parts of Rhizoma Chuanxiong, 15 parts of Radix Angelicae Sinensis, 22 parts of motherwort, 20 parts of polygonum cuspidate, 8 parts of leech, white
22 parts of HERBA HEDYOTIS DIFFUSAE of flower, 20 parts of Radix Isatidis, 20 parts of oriental wormwood, Charred Triplet be 22 parts each, 15 parts of radish seed, Schisandra chinensis 20
Part, 12.5 parts of radix bupleuri, 22 parts of rabdosia lophanthide, 22 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 12.5 parts of dried orange peel, 12.5 parts of green peel, dried human placenta 10
Part.
Wherein, the Chinese medicine composition is that bulk pharmaceutical chemicals press pharmacy conventional method, is added or is added without auxiliary material to be used, be made
Clinically acceptable dosage form.
Wherein, the dosage form can be powder, granule, capsule, tablet, oral liquid.
The present invention also provides above-mentioned treatment hepatitis B, the preparation method of the Chinese medicine composition of cirrhosis, it includes following step
It is rapid: (1) to weigh bulk pharmaceutical chemicals according to the ratio, put it into casserole, the dipped powder 3cm of clear water is added, and impregnate 10-20min；
(2) first the bulk pharmaceutical chemicals being immersed in casserole clear water are boiled with high heat, is changed to be cooked by slow fire 25min later, after
Leaching decocting liquid, it is spare；
(3) remaining filter residue will be filtered successively according to the operating method of step (1) and step (2) in step (2), carried out again
Processing, filters to take decocting liquid, spare；
(4) mixing the decocting liquid obtained in step (2) and step (3) and being concentrated into relative density is 1.25, under stirring condition, is delayed
The slow 90%v/v ethanol solution that 2 times of amounts are added, is stirred, and is stood, and filtering, filtrate low-temperature evaporation is concentrated into relative density and is
1.45, and ethyl alcohol is recycled, obtain concentrate；
(5) water and auxiliaries are added to be spray-dried at decoction, or by concentrate concentrate, capsule, piece is made in addition auxiliary material
Agent, pill, granule.
Wherein, in step (4), the mixing time is 21 minutes, and time of repose is 45 hours.
Wherein, in step (4), spray drying condition are as follows: inlet air temperature is 110-120 DEG C, and outlet temperature is 80 DEG C,
Temperature of charge is 55 DEG C, atomizing pressure 0.6MPa, spray velocity 6ml/s.
Embodiment 4
The raw material composition and ratio of a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, the Chinese medicine composition are as follows: ginseng
15 parts, 30 parts of Radix Astragali, 50 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 30 parts of radix paeoniae rubra, 20 parts of Radix Salviae Miltiorrhizae, 10 parts of trigone, curcuma zedoary
18 parts, 6 parts of Eupolyphoge sinensis, 15 parts of Rhizoma Chuanxiong, 10 parts of Radix Angelicae Sinensis, 20 parts of motherwort, 10 parts of polygonum cuspidate, 6 parts of leech, white flower
30 parts of HERBA HEDYOTIS DIFFUSAE, 10 parts of Radix Isatidis, 30 parts of oriental wormwood, Charred Triplet be 15 parts each, 15 parts of radish seed, Schisandra chinensis 10
Part, 15 parts of radix bupleuri, 15 parts of rabdosia lophanthide, 30 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 10 parts of dried orange peel, 15 parts of green peel, 5 parts of dried human placenta.
Wherein, the Chinese medicine composition is that bulk pharmaceutical chemicals press pharmacy conventional method, is added or is added without auxiliary material to be used, be made
Clinically acceptable dosage form.
Wherein, the dosage form can be powder, granule, capsule, tablet, oral liquid.
The present invention also provides above-mentioned treatment hepatitis B, the preparation method of the Chinese medicine composition of cirrhosis, it includes following step
It is rapid: (1) to weigh bulk pharmaceutical chemicals according to the ratio, put it into casserole, the dipped powder 2.5cm of clear water is added, and impregnate 18min；
(2) first the bulk pharmaceutical chemicals being immersed in casserole clear water are boiled with high heat, is changed to be cooked by slow fire 23min later, then
Decocting liquid is filtered to take, it is spare；
(3) remaining filter residue will be filtered successively according to the operating method of step (1) and step (2) in step (2), carried out again
Processing, filters to take decocting liquid, spare；
(4) mixing the decocting liquid obtained in step (2) and step (3) and being concentrated into relative density is 1.20, under stirring condition, is delayed
The slow 90%v/v ethanol solution that 2 times of amounts are added, is stirred, and is stood, and filtering, filtrate low-temperature evaporation is concentrated into relative density and is
1.50, and ethyl alcohol is recycled, obtain concentrate；
(5) water and auxiliaries are added to be spray-dried at decoction, or by concentrate concentrate, capsule, piece is made in addition auxiliary material
Agent, pill, granule.
Wherein, in step (4), the mixing time is 22 minutes, and time of repose is 40 hours.
Wherein, in step (4), spray drying condition are as follows: inlet air temperature is 110 DEG C, and outlet temperature is 85 DEG C, material
Temperature is 50 DEG C, atomizing pressure 0.7MPa, spray velocity 4ml/s.
Embodiment 5
The raw material composition and ratio of a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, the Chinese medicine composition are as follows: ginseng
30 parts, 40 parts of Radix Astragali, 60 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 30 parts of radix paeoniae rubra, 15 parts of Radix Salviae Miltiorrhizae, 16 parts of trigone, curcuma zedoary
12 parts, 6 parts of Eupolyphoge sinensis, 15 parts of Rhizoma Chuanxiong, 10 parts of Radix Angelicae Sinensis, 30 parts of motherwort, 10 parts of polygonum cuspidate, 10 parts of leech, white flower
15 parts of HERBA HEDYOTIS DIFFUSAE, 25 parts of Radix Isatidis, 15 parts of oriental wormwood, Charred Triplet be 15 parts each, 20 parts of radish seed, Schisandra chinensis 10-30
Part, 9 parts of radix bupleuri, 30 parts of rabdosia lophanthide, 15 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 10 parts of dried orange peel, 15 parts of green peel, 5 parts of dried human placenta.
Wherein, the Chinese medicine composition is that bulk pharmaceutical chemicals press pharmacy conventional method, is added or is added without auxiliary material to be used, be made
Clinically acceptable dosage form.
Wherein, the dosage form can be powder, granule, capsule, tablet, oral liquid.
The present invention also provides above-mentioned treatment hepatitis B, the preparation method of the Chinese medicine composition of cirrhosis, it includes following step
It is rapid: (1) to weigh bulk pharmaceutical chemicals according to the ratio, put it into casserole, the dipped powder 3.5cm of clear water is added, and impregnate 10min；
(2) first the bulk pharmaceutical chemicals being immersed in casserole clear water are boiled with high heat, is changed to be cooked by slow fire 20min later, after
Leaching decocting liquid, it is spare；
(3) remaining filter residue will be filtered successively according to the operating method of step (1) and step (2) in step (2), carried out again
Processing, filters to take decocting liquid, spare；
(4) mixing the decocting liquid obtained in step (2) and step (3) and being concentrated into relative density is 1.25, under stirring condition, is delayed
The slow 90%v/v ethanol solution that 2 times of amounts are added, is stirred, and is stood, and filtering, filtrate low-temperature evaporation is concentrated into relative density and is
1.40, and ethyl alcohol is recycled, obtain concentrate；
(5) water and auxiliaries are added to be spray-dried at decoction, or by concentrate concentrate, capsule, piece is made in addition auxiliary material
Agent, pill, granule.
Wherein, in step (4), the mixing time is 20 minutes, and time of repose is 50 hours.
Wherein, in step (4), spray drying condition are as follows: inlet air temperature is 113 DEG C, and outlet temperature is 80 DEG C, material
Temperature is 57 DEG C, atomizing pressure 0.55MPa, spray velocity 5ml/s.
Experimental example
Case 1: poplar, female, 73 years old, in July, 2013 examined, main suit's abdominal distension, out of strength, thin, both sides of the chest distending pain.Clinic is main
Want sign: abdomen is grand, soft, no tenderness, and hepatic region is without button pain, and liver palms, urine are yellow, and sign of ascites is positive, and tongue is purple dark, and veins string chemically examines liver function
Abnormal, paddy third, glutamic-oxalacetic transaminease are respectively 357 and 477.4；Total protein 62.0；Albumin is 35.0, globulin
27.0；Bilirubin direct 6.4, total bilirubin 12.6.Hepatitis B virus surface antigen is positive, surface antibody is positive, and core is anti-
Body is positive, and B type color doppler ultrasonic inspection: liver volume form substantially reduces, rough, and liver parenchyma echo is not
Well-balanced, portal vein diameter about 15mm, extrahepatic duct has no expansion.Splenomegaly, long river rising in Ningxia and flowing into central Shaanxi 18.1cm, thick 6.3cm, form are full
Full, surface is smooth, and substantive echo is uniform.
Clinical diagnosis are as follows: be diagnosed as hbv-liver cirrhosis, portal hypertension, splenomegaly and spleen is high, ascites is formed, this is taken
Invention drug, daily decoction can also once be divided into takes twice, sooner or later bfore meals to be preferred.Taken drug 90 of the present invention
Further consultation after it, for patient without abdominal distension, diet sleep is good.Physical examination, abdomen equal soft, no flatulence, and both sides of the chest knocking is without pain sense, spirit
Still, liver palms is good, tongue nature is light red, have rosy cheeks, arteries and veins it is thin.The super inspection result of B shows that liver volume still reduces, Echo heterogenicity
Even, liver shows to owe smooth, portal vein diameter about 12mm, Spleen Size long river rising in Ningxia and flowing into central Shaanxi 15.1cm, thick 4.3cm；Have no that ascites is formed.
Liver function result of laboratory test shows that paddy third, glutamic-oxalacetic transaminease are respectively 13.0 and 36.0；Total protein 67.0；Albumin is
33.0；Globulin 34.0；Bilirubin direct 9.2；Indirect bilirubin 13.2；Total bilirubin 22.4.Hepatitis B inspection,
Hepatovirus surface antigen positive, surface antibody are positive, core antibody positive, enjoin its maintenance dose medication as before of going back, maintenance dose
It is 1 time on the 1st, administration is same as above.It is checked after 180 days, the super inspection result of B shows that liver volume still reduces, and echo is equal earlier above
Even, liver shows to owe smooth, portal vein diameter about 11mm, Spleen Size major diameter 14.1cm, thick 4.2cm；It is remaining normal.
Case 2: Zhang, female, 69 years old, in July, 2012 examined, and appetite is poor, abdominal distention after meal, out of strength, and both sides of the chest are swollen
Bitterly.Take Entecavir treatment.Clinical main physical signs: abdomen equals soft, no tenderness, and hepatic region is without button pain, and no liver palms, urine are yellow, and tongue is purple
Secretly, veins string, chemical examination liver function is abnormal, and paddy third, glutamic-oxalacetic transaminease are respectively 60 and 77.4；Total protein 57.0；Albumin is
30.0, globulin 27.0；Bilirubin direct 10.4, total bilirubin 22.6.Hepatitis B virus surface antigen is positive, remaining feminine gender,
B type color doppler ultrasonic inspection: liver volume form is substantially normal, rough, liver parenchyma echo unshapeliness, door
Arteries and veins diameter about 13mm, extrahepatic duct have no expansion.Splenomegaly, long 15.1cm are thick
4.3cm, form is full, and surface is smooth, and substantive echo is uniform.
Clinical diagnosis are as follows: be diagnosed as hbv-liver cirrhosis, portal hypertension, splenomegaly, tell it and deactivate all drugs, taken with changing
With drug of the present invention, daily decoction can also once be divided into takes twice, sooner or later bfore meals to be preferred.Taken drug of the present invention
Further consultation after 60 days, master state, can have a meal, after meal not abdominal distension.Through looking into, abdomen is without flatulence, and both sides of the chest knocking is without pain sense, spirit
Still, tongue nature is light red, have rosy cheeks, arteries and veins it is thin.The super inspection result of B shows liver morphology normal in size, and Echo heterogenicity is even, liver
Show still to owe smooth, Spleen Size long 13.1cm, thick 3.3cm；Portal vein diameter about 10mm, liver function result of laboratory test show, paddy
The third, glutamic-oxalacetic transaminease is respectively 28.0 and 26.0；Total protein 70.0；Albumin is 33.0；Globulin 30.0；Direct gallbladder
Red pigment 3.2；Indirect bilirubin 14.2；Total bilirubin 19.5；Hepatitis B inspection, hepatitis B virus surface antigen is positive, remaining
Feminine gender enjoins its maintenance dose medication as before of going back, and maintenance dose is 1 time on the 1st, and administration is same as above.All are checked after 90 days just
Often.
3 Mr. Wang, male of case, 39 years old, in March, 2012 examined, and took hepatagogue and Entecavir, checked second
Hepatopathy is that great three positive, splenomegaly be not light always, is had a meal few, abdominal distention after meal feels run-down, thin, both sides of the chest distending pain.
Clinical diagnosis are as follows: right rib tenderness has lump, and pain, liver palms, urine are yellow, and tongue is purple dark, veins string, is chemically examining liver function not just
Often, paddy third, glutamic-oxalacetic transaminease are respectively 189.0 and 176.7；Total protein 59.0；Albumin is 31.0, globulin
36.0；Bilirubin direct 15.5, total bilirubin 36.5.Hepatitis B virus positive, B type color doppler ultrasonic inspection: liver
Dirty volume-diminished, form is substantially normal, rough, liver parenchyma echo unshapeliness, the broadening deficient rule out of shape of portal vein diameter,
Extrahepatic duct has no expansion.Splenomegaly, thick 4.7cm, long river rising in Ningxia and flowing into central Shaanxi 13.1cm, form is full, and surface is smooth, and substantive echo is equal
It is even, splenic vein diameter 0.8cm.
Clinical diagnosis are as follows: hbv-liver cirrhosis tells it and deactivates all drugs, takes drug of the present invention with changing, daily to decoct
It can also once be divided into and take twice, it is sooner or later bfore meals to be preferred.Entecavir is changed to take 2/3 daily, after taking 7 days again
Change and take half, then change again after taking 7 days and take 1/3, withdraws Entecavir after taking 7 days.Taken drug 30 of the present invention
Further consultation after it, master state, can have a meal, and abdominal distension, urine are yellow yet after meal.Through looking into, abdomen without flatulence, both sides of the chest knocking without
Pain sense, does not lay one's hand under right rib and lump, spirit still, it is thin mitigate, liver palms is good, tongue nature is light red, have rosy cheeks, arteries and veins it is thin.90
Check is all gone well in the future, and the long 12.4cm of spleen, thick 3.9cm, there has been no recurrence since follow-up.
Hbv-liver cirrhosis diagnosis and treatment standard: by clinical symptoms being diet reduction, abdominal distention after meal, nausea, tired spirit, out of strength,
Syntexis, both sides of the chest distending pain, right flank distending pain are hard, and liver palm, urine are yellow, and tongue is purple dark, and veins string, chemical examination liver function is abnormal, hepatitis B
The positive, liver, splenomegaly when B type color doppler ultrasonic checks, liver envelope thicken, and liver surface is rough, and liver parenchyma is returned
Sound enhancing, coarse unshapeliness, portal vein diameter is broadening, and ascites is diagnosed as hbv-liver cirrhosis.
Effective: the above clinical symptoms all disappear；
It is effective: the above clinical symptoms partial disappearance；
It is invalid: effective and effective evaluation criteria person is not achieved.
Treatment effect after accumulative 200 hepatitis B patients to be taken to 3 courses for the treatment of of medicine of the present invention counts, often
Day decocts
It takes once, 7 as a treatment course.Statistical result is shown in Table 1
| Treatment time | Effective/example (%) | Effectively/example (%) | In vain/example (%) |
| Treat 3 courses for the treatment of | 135(67.5) | 24(26.6) | 6(3) |
Above-mentioned clinical research shows: 200 hepatitis B patients of pharmaceutical composition clinical treatment of the present invention treat 3 courses for the treatment of
Effective 135 afterwards, effective 24, invalid 6, total effective rate reaches 94.1%.Through treating patient's items clinical condition
Shape is also obviously improved, and quality of life improves, and does not occur symptom deterioration person, and the later period is without recurrence.
Pharmaceutical composition of the present invention has no toxic side effect by clinical observation simultaneously.
In conclusion the present invention meets Chinese medical discrimination theory in Chinese medicine selection and compatibility, and preparation method is simple,
Be made after compatibility water decoction or it is other be suitable for the medicament taken, to acute and chronic hepatitis B inflammation, hepatitis B big and small three Yang, hepatitis, cirrhosis,
Liver ascites, hepatosplenomegaly, Laennec's cirrhosis, alcoholic liver, and good effect, quick, treating both manifestation and root cause of disease, and have no toxic side effect, it reaches
Complementary purpose in drug matching is arrived.
Although it is upper described be merely a preferred embodiment of the present invention only, be not intended to restrict the invention, referring to aforementioned implementation
Example invention is explained in detail, for those skilled in the art, its still can be to foregoing embodiments
Documented technical solution is modified or equivalent replacement of some of the technical features.It is all in spirit of the invention
With within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating hepatitis B, cirrhosis, which is characterized in that the raw material of the Chinese medicine composition forms and matches
Than as follows: 10-30 parts of ginseng, 30-60 parts of Radix Astragali, 30-60 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of Poria cocos, 15-30 parts of radix paeoniae rubra, Radix Salviae Miltiorrhizae 15-30
Part, 10-18 parts of trigone, 10-18 parts of curcuma zedoary, 6-15 parts of Eupolyphoge sinensis, 10-15 parts of Rhizoma Chuanxiong, 10-20 parts of Radix Angelicae Sinensis, 15-30 parts of motherwort,
10-30 parts of polygonum cuspidate, 6-10 parts of leech, 15-30 parts of oldenlandia diffusa, 10-30 parts of Radix Isatidis, 10-30 parts of oriental wormwood, Charred Triplet are each
15-30 parts, it is 10-20 parts of radish seed, 10-30 parts of Schisandra chinensis, 9-15 parts of radix bupleuri, 15-30 parts of rabdosia lophanthide, 15-30 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, old
10-15 parts of skin, 10-15 parts of green peel, 5-15 parts of dried human placenta.
2. the Chinese medicine composition for the treatment of hepatitis B according to claim 1, cirrhosis, which is characterized in that the Chinese traditional medicine composition
The raw material composition and ratio of object are as follows: 20 parts of ginseng, 45 parts of Radix Astragali, 45 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 22 parts of radix paeoniae rubra, 23 parts of Radix Salviae Miltiorrhizae,
It is 14 parts of trigone, 14 parts of curcuma zedoary, 11 parts of Eupolyphoge sinensis, 12.5 parts of Rhizoma Chuanxiong, 15 parts of Radix Angelicae Sinensis, 22 parts of motherwort, 20 parts of polygonum cuspidate, 8 parts of leech, white
22 parts of HERBA HEDYOTIS DIFFUSAE of flower, 20 parts of Radix Isatidis, 20 parts of oriental wormwood, Charred Triplet be 22 parts each, 15 parts of radish seed, 20 parts of Schisandra chinensis, radix bupleuri 12.5
Part, 22 parts of rabdosia lophanthide, 22 parts of stir-baked CARAPAX TRIONGCIS with sand then treated with vinegar, 12.5 parts of dried orange peel, 12.5 parts of green peel, 10 parts of dried human placenta.
3. the Chinese medicine composition for the treatment of hepatitis B according to claim 1 or 2, cirrhosis, which is characterized in that the Chinese medicine group
Closing object is that bulk pharmaceutical chemicals press pharmacy conventional method, is added or is added without auxiliary material to be used, clinically acceptable dosage form is made.
4. the Chinese medicine composition for the treatment of hepatitis B according to claim 3, cirrhosis, which is characterized in that the dosage form can be with
It is powder, granule, capsule, tablet, oral liquid.
5. the preparation method of the Chinese medicine composition for the treatment of hepatitis B according to claim 1 or 2, cirrhosis, which is characterized in that
It includes the following steps:
(1) bulk pharmaceutical chemicals are weighed according to the ratio, are put it into casserole, the dipped powder 2-4cm of clear water are added, and impregnate 10-20min；
(2) first the bulk pharmaceutical chemicals being immersed in casserole clear water are boiled with high heat, is changed to be cooked by slow fire 20-30min later, then
Decocting liquid is filtered to take, it is spare；
(3) remaining filter residue will be filtered successively according to the operating method of step (1) and step (2) in step (2), carried out again
Processing, filters to take decocting liquid, spare；
(4) mixing the decocting liquid obtained in step (2) and step (3) and being concentrated into relative density is 1.20-1.30, stirring condition
Under, it is slowly added into the 90%v/v ethanol solution of 2 times of amounts, is stirred, is stood, filtering, filtrate low-temperature evaporation is concentrated into relative density and is
1.40-1.50 and recycle ethyl alcohol, obtain concentrate；
(5) water and auxiliaries are added to be spray-dried at decoction, or by concentrate concentrate, capsule, piece is made in addition auxiliary material
Agent, pill, granule.
6. the preparation method of the Chinese medicine composition for the treatment of hepatitis B according to claim 5, cirrhosis, which is characterized in that step
Suddenly in (4), the mixing time is 18-25 minutes, and time of repose is 35-55 hours.
7. the preparation method of the Chinese medicine composition for the treatment of hepatitis B according to claim 5, cirrhosis, which is characterized in that step
Suddenly in (4), spray drying condition are as follows: inlet air temperature is 110-120 DEG C, and outlet temperature is 75-85 DEG C, temperature of charge 50-60
DEG C, atomizing pressure 0.5-0.7MPa, spray velocity 4-8ml/s.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116036217A (en) * | 2022-12-23 | 2023-05-02 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
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| CN104174005A (en) * | 2014-09-15 | 2014-12-03 | 青岛市市立医院 | Medicine for treating hepatitis b cirrhosis |
| CN105288513A (en) * | 2015-12-07 | 2016-02-03 | 包永昌 | Traditional Chinese medicine composition for treating hepatitis B and cirrhosis |
| CN108578605A (en) * | 2018-07-18 | 2018-09-28 | 合肥华盖生物科技有限公司 | A kind of Chinese medicine composition for treating diabetes |
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| CN104174005A (en) * | 2014-09-15 | 2014-12-03 | 青岛市市立医院 | Medicine for treating hepatitis b cirrhosis |
| CN105288513A (en) * | 2015-12-07 | 2016-02-03 | 包永昌 | Traditional Chinese medicine composition for treating hepatitis B and cirrhosis |
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| CN116036217A (en) * | 2022-12-23 | 2023-05-02 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
| CN116036217B (en) * | 2022-12-23 | 2023-11-21 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
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Application publication date: 20190111 |