CN109163681A - A kind of sealing agent spray area detection device and detection method - Google Patents
A kind of sealing agent spray area detection device and detection method Download PDFInfo
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- CN109163681A CN109163681A CN201811023782.5A CN201811023782A CN109163681A CN 109163681 A CN109163681 A CN 109163681A CN 201811023782 A CN201811023782 A CN 201811023782A CN 109163681 A CN109163681 A CN 109163681A
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- sealing agent
- gear
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- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 85
- 238000007789 sealing Methods 0.000 title claims abstract description 83
- 239000007921 spray Substances 0.000 title claims abstract description 52
- 238000001514 detection method Methods 0.000 title claims abstract description 49
- 239000003814 drug Substances 0.000 claims abstract description 29
- 230000005540 biological transmission Effects 0.000 claims abstract description 25
- 238000005507 spraying Methods 0.000 claims abstract description 18
- 230000009467 reduction Effects 0.000 claims abstract description 16
- 230000007246 mechanism Effects 0.000 claims abstract description 14
- 238000012360 testing method Methods 0.000 claims abstract description 5
- 239000003106 tissue adhesive Substances 0.000 claims abstract description 4
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 27
- 229920001223 polyethylene glycol Polymers 0.000 claims description 27
- 239000007788 liquid Substances 0.000 claims description 16
- 125000000524 functional group Chemical group 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 11
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 9
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 9
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000001356 surgical procedure Methods 0.000 claims description 7
- 239000007853 buffer solution Substances 0.000 claims description 6
- 102000007562 Serum Albumin Human genes 0.000 claims description 5
- 108010071390 Serum Albumin Proteins 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 5
- NWAGXLBTAPTCPR-UHFFFAOYSA-N 5-(2,5-dioxopyrrolidin-1-yl)oxy-5-oxopentanoic acid Chemical compound OC(=O)CCCC(=O)ON1C(=O)CCC1=O NWAGXLBTAPTCPR-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 108010027529 Bio-glue Proteins 0.000 claims description 3
- LFIKKCLFUXSIMK-UHFFFAOYSA-N C(CCCCCCCCC(=O)O)(=O)O.C1(CCC(N1)=O)=O Chemical compound C(CCCCCCCCC(=O)O)(=O)O.C1(CCC(N1)=O)=O LFIKKCLFUXSIMK-UHFFFAOYSA-N 0.000 claims description 3
- 229920000305 Nylon 6,10 Polymers 0.000 claims description 3
- 239000005357 flat glass Substances 0.000 claims description 3
- 239000002874 hemostatic agent Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- CXMXRPHRNRROMY-UHFFFAOYSA-N n-Decanedioic acid Natural products OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims description 3
- 239000000123 paper Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 239000002985 plastic film Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 2
- 230000003068 static effect Effects 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- PMSGJXMYHUSZEI-UHFFFAOYSA-N butanedioic acid;pyrrolidine-2,5-dione Chemical compound O=C1CCC(=O)N1.OC(=O)CCC(O)=O PMSGJXMYHUSZEI-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 description 19
- 229920002892 amber Polymers 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 7
- 230000023597 hemostasis Effects 0.000 description 5
- 239000000017 hydrogel Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- CQVWXNBVRLKXPE-UHFFFAOYSA-N 2-octyl cyanoacrylate Chemical compound CCCCCCC(C)OC(=O)C(=C)C#N CQVWXNBVRLKXPE-UHFFFAOYSA-N 0.000 description 2
- 229920001651 Cyanoacrylate Polymers 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 208000031737 Tissue Adhesions Diseases 0.000 description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000002682 general surgery Methods 0.000 description 2
- 150000002466 imines Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 2
- 230000010148 water-pollination Effects 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 210000005067 joint tissue Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/28—Measuring arrangements characterised by the use of optical techniques for measuring areas
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of sealing agent spray area detection device and detection methods.Including such as lower component: bracket and transmission component, in the shell of cantilever tip, transmission component is connect with housing into rotation comprising transmission gear and reduction gearing, the transmission gear are engaged with reduction gearing；Driving assembly, including driving gear and driving motor, at least driving gear are set in the housing, and driving gear connect with housing into rotation and engages with reduction gearing, and the output shaft of driving motor couples with driving gear, and the body of driving motor is relative to housing stationary；It further include drive screw and telescopic rod, drive screw is connect with transmission gear, and telescopic rod is set to drive screw end；Testing agency, including medicine mixer baffle and sealing agent receiver board, are fixed on pedestal lower end in parallel from top to down, and the medicine mixer baffle is additionally provided with spraying hole；Control mechanism.Present invention is particularly suitable for the detections of the spray area of the surgical operation sealing agent or tissue adhesive that contact with tissue.
Description
Technical field
The invention belongs to material property detection device technical fields, and in particular to a kind of sealing agent spray area detection device
And detection method.
Background technique
Hydrogel is a kind of three-dimensional net structure polymer with hydrophilic radical as a kind of biocompatible materials,
Due between polymer chain physical crosslinking and chemical crosslinking effect, hydrogel can be water-swellable but not soluble in water and keep certain
Shape.Medically, hydrogel can be used for Wound dressing, hand post-operation adhesion preventing, hemostasis in operation, tissue filling, prevent tissue
Liquid leakage or gas leakage etc..Hydrogel is used as tissue fluid and leaks or when gas leakage mechanical blocks, also referred to as surgery hand
Art sealing agent.
Sealing agent has many potential medical applications, including closure wound, auxiliary suture or seam in surgical operation
Dowel, as the barrier for preventing post-operation adhesion and as hemostasis sealing agent etc..Fibrin Glue is commonly used for surgery hand at present
Art sealing agent, it is made of human or animal's fibrinogen, fibrin ferment and gel promotor.As a kind of two-component adhesive,
Reaction forms gel rapidly after mixing.Tissue can be adhered to by being formed by gel, and hemostasis, bridge joint tissue surface of a wound etc. are until more
It is combined into only.
Sealing agent sprays to target position after generally passing through prefilled syringe or double copmled medicine mixer mixing, after spraying
Coverage area (i.e. spray area) has important references meaning for the clinical application of sealing agent.Such as Bard company standard 4ml
Progel sealing agent, which sprays on the surface of a wound, can cover about 40 square centimeters of area (1 millimeter of thickness).Sealing agent spray-coating surface
It accumulates related to factors such as the design of medicine mixer nozzle, sealing agent spraying rate and sealing agent gelation times.Sealing agent spray area
It is evaluation one important Testing index of sealing agent physical property.There is presently no a kind of dresses of accurate detection sealing agent spray area
It sets, during the detection of sealing agent spray area, generally by the way of manual spray, arbitrariness is also big for manual spray, detection
Result error is very big.Therefore, there is an urgent need to develop a kind of new simple and feasible sealing agent spray area detection device.
Summary of the invention
It is an object of the present invention to solving the deficiencies in the prior art, a kind of sealing agent spray area detection dress is provided
It sets.
The second object of the present invention is to provide a kind of sealing agent spray area detection method.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of sealing agent spray area detection device, the spray area detection device include such as lower component:
Bracket and transmission component, in the shell of cantilever tip, transmission component is connect with housing into rotation comprising is passed
Moving gear and reduction gearing, the transmission gear are engaged with reduction gearing；
Driving assembly, including driving gear and driving motor, at least driving gear are set in the housing, and drive gear and shell
Rotation connection and engage with reduction gearing, the output shaft of driving motor couples with gear is driven, the body of driving motor relative to
Housing stationary；
It further include telescopic component, the telescopic component includes drive screw, telescopic rod, locating part and cover, drive screw
It is connect with transmission gear, locating part is spirally connected with drive screw, and telescopic rod is detachably connected with locating part, and cover is placed in transmission spiral shell
Outside bar, telescopic rod and locating part, locating part is at least partly abutted with cover and can be slid axially along cover inner wall；
Testing agency, including medicine mixer baffle and sealing agent receiver board, are fixed on pedestal lower end in parallel from top to down, described
Medicine mixer baffle is additionally provided with spraying hole；
Control mechanism is electrically connected with driving mechanism, for controlling the open and close of driving motor, and then via transmission spiral shell
Bar and locating part control the stretching and retraction of telescopic rod.
Preferably, the bracket is rectangular frame structure, and shell is detachably connected with bracket, and the reduction gearing is adopted
With the double-deck horizontal gear, the control mechanism is PLC controller.
Preferably, the double-deck horizontal gear is equipped with two groups, the respectively first double-deck horizontal gear and the second double-deck horizontal gear, the
The diameter of the upper sub- gear of pair of lamina horizontal gear is greater than the diameter of lower sub- gear, and lower sub- gear is engaged with driving gear；Second pair
The diameter of the upper sub- gear of layer horizontal gear is less than the diameter of lower sub- gear, the upper sub- gear and the second bilayer of the first double-deck horizontal gear
The lower sub- gear engagement of horizontal gear, the upper sub- gear of the second double-deck horizontal gear are engaged with transmission gear.
Preferably, the aperture in the spraying hole is 5-20mm, the bracket, medicine mixer baffle and sealing agent receiver board plus
Work material is uniform, is that rigid plastics or metal are made.
Based on the detection method of sealing agent spray area detection device of the present invention, described method includes following steps:
S1: simultaneously trial operation inspection is spare for the assembling of sealing agent spray area detection device；
S2: sealing agent is configured according to sealing agent operation instruction, configured sealing agent is injected into spare in medicine mixer；
S3: taking a support chip to be placed on sealing agent receiver board, and medicine mixer is placed on medicine mixer baffle, medicine mixer outlet pair
Quasi- spraying hole, open control mechanism adjust driving motor speed, and then drive telescopic rod to stretch out by drive screw, push mixed
Medicine device push rod, sealing agent spray on support chip, spraying finish to be sealed dose be formed by curing gel after, taken pictures with digital camera,
Spray area is calculated using Image J software.
Preferably, the support chip is clean blank sheet of paper or sheet glass or plastic sheet.
Detection device of the present invention is suitble to Progel sealing agent (the white egg of the sealing agent such as Bard company of detection
White/polyethylene glycol gel), Coseal sealing agent (two-component polyethylene glycol gel), the Confluent of Baxter company
Surgical company DuraSeal sealing agent, HyperBranch Medical Technology company's Adherus sealing agent and
Ocuseal sealing agent, CryoLife company BioGlue surgical adhesive etc..In addition, the device is also applied for tissue adhesion
The spray area inspection of agent (the DERMABOND surgical appliance adhesive of such as Ethicon) and hemostat (such as freeze-drying condition of human blood fibrin glue)
It surveys.
The spray area detection device of the invention, it may also be used for the spray area of detection seralbumin gel,
The seralbumin gel can be prepared via a method which:
(1), prepare the first liquid component: it is in 6.0-10.0 buffer solution with obtained that seralbumin, which is dissolved in pH range,
It is the serum albumin solution of 5%-45% (w/v) to concentration；Preferably, the serum albumin solution can be located via radiation
Reason, irradiation dose range is between 5kGy-45kGy；
(2), it prepares second liquid component: the hydrophilic polymer solid component containing electrophilic functional group is dissolved in pH model
It encloses in the buffer solution for 6.0-10.0, it is poly- that preparation obtains the hydrophily containing electrophilic functional group that concentration is 5%~45% (w/v)
Polymer component solution, wherein the hydrophilic polymer components containing electrophilic functional group and the serum in the first liquid component are white
The mass ratio of albumen is 0.3-2；
(3), the first liquid component is mixed with second liquid component, is cross-linked to form seralbumin gel.
Hydrophilic polymer containing electrophilic functional group can be selected from double amber imide propionic acid ester group polyethylene glycol, double ambers
Amber acid imide succinic acid ester group polyethylene glycol, double amber imide glutaric acid ester group polyethylene glycol, double amber imide decanedioic acid
Ester group polyethylene glycol, four succinimidyl glutarate of pentaerythritol polyethylene glycol ether, four succinyl of pentaerythritol polyethylene glycol ether
One of imines succinic acid, four succinimide decanedioic acid of pentaerythritol polyethylene glycol ether or a variety of, molecular weight 1000-
100000, preferably 2000-50000, more preferable 3000-20000.It is preferred that double amber imide succinic acid ester group polyethylene glycol,
Molecular weight is 1000-100000, preferably 2000-50000, more preferable 3000-20000.
The seralbumin gel can be used for the bonding, hemostasis of wound in the various surgical operations of human body, antiseep or
Application in preventing adhesion, such as medically can be used for angiocarpy, department of general surgery, department of plastic surgery, neurosurgery, ophthalmology, bone surgery
Or defective tissue is sealed during pulmonary surgery.
Spray area detection device of the present invention is particularly suitable for the surgical operation sealing agent contacted with tissue or group
Knit the spray area detection of adhesive.The device is economical and practical, convenient, high performance-price ratio, detects light and flexible, people convenient to use
The operation of member, it is safer, reliable, environmentally friendly, convenient to have the characteristics that.
Detailed description of the invention
Fig. 1 is schematic perspective view of the invention；
Fig. 2 is the main view of Fig. 1；
Fig. 3 is the schematic perspective view of transmission component in Fig. 1；
Fig. 4 is the top view of Fig. 3；
Fig. 5 is the cross-sectional view of Fig. 4.
Fig. 6 is the perspective view of telescopic component；
Fig. 7 is the cross-sectional view of telescopic component.
In figure: 1, bracket, 2, shell, 3, transmission gear, 4, reduction gearing, 4a, the first double-deck horizontal gear, 4b, second couple
Layer horizontal gear, 5, driving gear, 6, driving motor, 7, drive screw, 8, telescopic rod, 9, medicine mixer baffle, 10, sealing agent reception
Plate, 11, spraying hole, 12, control mechanism, 13, locating part, 14, cover.
Specific embodiment
Below by specific embodiment, and in conjunction with attached drawing, technical scheme of the present invention will be further explained in detail.
As shown in figs. 1-7, a kind of sealing agent spray area detection device, the spray area detection device include such as the following group
Part:
Bracket 1 and transmission component, in the shell 2 on 1 top of bracket, transmission component and shell 2 are rotatablely connected, packet
Transmission gear 3 and reduction gearing 4 are included, the transmission gear 3 is engaged with reduction gearing 4；
Driving assembly, including driving gear 5 and driving motor 6, at least driving gear 5 are set in shell 2, drive gear 5
It is rotatablely connected with shell 2 and is engaged with reduction gearing 4, the output shaft of driving motor 6 couples with driving gear 5, driving motor 6
Body is static relative to shell 2；
It further include telescopic component, the telescopic component includes drive screw 7, telescopic rod 8, locating part 13 and cover 14, is passed
Dynamic screw rod 7 is connect with transmission gear 3, and locating part 13 is spirally connected with drive screw 7, and telescopic rod 8 is detachably connected with locating part 13, such as
Be spirally connected or be clamped, cover 14 is placed in outside drive screw 7, telescopic rod 8 and locating part 13, locating part 13 at least partly with cover 14
It abuts and can slide axially along 14 inner wall of cover；
Testing agency, including medicine mixer baffle 9 and sealing agent receiver board 10, are fixed on 1 lower end of bracket in parallel from top to down,
The medicine mixer baffle 9 is additionally provided with spraying hole 11；
Control mechanism is electrically connected with driving mechanism 6, for controlling the open and close of driving motor 6, and then via transmission
Screw rod 7 and locating part 13 control the stretching and retraction of telescopic rod 8.
Specific to the present invention, the bracket 1 is rectangular frame structure, and shell 2 is detachably connected with bracket 1, described
For reduction gearing 4 using the double-deck horizontal gear, the control mechanism 12 is PLC controller.
In the present invention, the bilayer horizontal gear is equipped with two groups, the double-deck flat tooth of the respectively first bilayer horizontal gear 4a and second
4b is taken turns, the diameter of the upper sub- gear of the first double-deck horizontal gear 4a is greater than the diameter of lower sub- gear, and lower sub- gear is nibbled with driving gear
It closes；The diameter of the upper sub- gear of the second double-deck horizontal gear 4b is less than the diameter of lower sub- gear, the upper son of the first double-deck horizontal gear 4a
Gear is engaged with the lower sub- gear of the second double-deck horizontal gear 4b, and the upper sub- gear of the second double-deck horizontal gear 4b is nibbled with transmission gear
It closes.
In embodiment of the present invention, the aperture in the spraying hole 11 is 5-20mm, the bracket 1,9 and of medicine mixer baffle
The Material Processing of sealing agent receiver board 10 is uniform, is that rigid plastics or metal are made.
Based on the detection method of sealing agent spray area detection device of the present invention, described method includes following steps:
S1: simultaneously trial operation inspection is spare for the assembling of sealing agent spray area detection device；
S2: sealing agent is configured according to sealing agent operation instruction, configured sealing agent is injected into spare in medicine mixer；
S3: taking a support chip to be placed on sealing agent receiver board, and medicine mixer is placed on medicine mixer baffle, medicine mixer outlet pair
Quasi- spraying hole, open control mechanism adjust driving motor speed, and then drive telescopic rod to stretch out by drive screw, push mixed
Medicine device push rod, sealing agent spray on support chip, spraying finish to be sealed dose be formed by curing gel after, taken pictures with digital camera,
Spray area is calculated using Image J software, the support chip is clean blank sheet of paper or sheet glass or plastic sheet.
Calculate spray area.The calculating process of Image J is as follows: (1) opening Image J software；(2) it selects in " File "
" Open " opens original image；(3) it chooses line measurement tool " Straight ", the straight line scribing line before in picture, this step
Rapid predominantly setting ratio ruler below；(4) " Set Scale " order in " Analyze " menu is opened, in " Known
The length actual value 20cm of distance " addition line segment；(4) " Freehand selections " is selected, along sealing agent gel
Draw circumference line in edge (except the dotted gel of spraying edge)；(5) " Meansure " in " Analyze " is selected to measure,
It is as the result is shown 100 square centimeters.
Detection device of the present invention is suitble to Progel sealing agent (the white egg of the sealing agent such as Bard company of detection
White/polyethylene glycol gel), Coseal sealing agent (two-component polyethylene glycol gel), the Confluent of Baxter company
Surgical company DuraSeal sealing agent, HyperBranch Medical Technology company's Adherus sealing agent and
Ocuseal sealing agent, CryoLife company BioGlue surgical adhesive etc..In addition, the device is also applied for tissue adhesion
The spray area inspection of agent (the DERMABOND surgical appliance adhesive of such as Ethicon) and hemostat (such as freeze-drying condition of human blood fibrin glue)
It surveys.
The spray area detection device of the invention, it may also be used for the spray area of detection seralbumin gel,
The seralbumin gel can be prepared via a method which:
(1), prepare the first liquid component: it is in 6.0-10.0 buffer solution with obtained that seralbumin, which is dissolved in pH range,
It is the serum albumin solution of 5%-45% (w/v) to concentration；Preferably, the serum albumin solution can be located via radiation
Reason, irradiation dose range is between 5kGy-45kGy；
(2), it prepares second liquid component: the hydrophilic polymer solid component containing electrophilic functional group is dissolved in pH model
It encloses in the buffer solution for 6.0-10.0, it is poly- that preparation obtains the hydrophily containing electrophilic functional group that concentration is 5%~45% (w/v)
Polymer component solution, wherein the hydrophilic polymer components containing electrophilic functional group and the serum in the first liquid component are white
The mass ratio of albumen is 0.3-2；
(3), the first liquid component is mixed with second liquid component, is cross-linked to form seralbumin gel.
Hydrophilic polymer containing electrophilic functional group can be selected from double amber imide propionic acid ester group polyethylene glycol, double ambers
Amber acid imide succinic acid ester group polyethylene glycol, double amber imide glutaric acid ester group polyethylene glycol, double amber imide decanedioic acid
Ester group polyethylene glycol, four succinimidyl glutarate of pentaerythritol polyethylene glycol ether, four succinyl of pentaerythritol polyethylene glycol ether
One of imines succinic acid, four succinimide decanedioic acid of pentaerythritol polyethylene glycol ether or a variety of, molecular weight 1000-
100000, preferably 2000-50000, more preferable 3000-20000.It is preferred that double amber imide succinic acid ester group polyethylene glycol,
Molecular weight is 1000-100000, preferably 2000-50000, more preferable 3000-20000.
The seralbumin gel can be used for the bonding, hemostasis of wound in the various surgical operations of human body, antiseep or
Application in preventing adhesion, such as medically can be used for angiocarpy, department of general surgery, department of plastic surgery, neurosurgery, ophthalmology, bone surgery
Or defective tissue is sealed during pulmonary surgery.
Above-mentioned embodiment is only a preferred solution of the present invention, not the present invention is made in any form
Limitation, there are also other variations and modifications on the premise of not exceeding the technical scheme recorded in the claims.
Claims (10)
1. a kind of sealing agent spray area detection device, it is characterised in that: the spray area detection device includes such as lower component:
Bracket and transmission component, in the shell of cantilever tip, transmission component is connect with housing into rotation comprising driving cog
Wheel and reduction gearing, the transmission gear are engaged with reduction gearing；
Driving assembly, including driving gear and driving motor, at least driving gear are set in the housing, and drive gear and housing into rotation
It connects and is engaged with reduction gearing, the output shaft of driving motor couples with driving gear, and the body of driving motor is relative to shell
It is static；
It further include telescopic component, the telescopic component includes drive screw, telescopic rod, locating part and cover, drive screw and is passed
Moving gear connection, locating part are spirally connected with drive screw, and telescopic rod is detachably connected with locating part, and cover is placed in drive screw, stretches
Outside contracting bar and locating part, locating part is at least partly abutted with cover and can be slid axially along cover inner wall；
Pedestal lower end, the mixed medicine are fixed in parallel from top to down in testing agency, including medicine mixer baffle and sealing agent receiver board
Device baffle is additionally provided with spraying hole；
Control mechanism is electrically connected with driving mechanism, for controlling the open and close of driving motor, and then via drive screw and
Locating part controls the stretching and retraction of telescopic rod.
2. sealing agent spray area detection device according to claim 1, it is characterised in that: the bracket is cuboid
Frame structure, shell are detachably connected with bracket, and for the reduction gearing using the double-deck horizontal gear, the control mechanism is PLC control
Device processed.
3. sealing agent spray area detection device according to claim 2, it is characterised in that: the bilayer horizontal gear is equipped with
Two groups, the respectively first double-deck horizontal gear and the second double-deck horizontal gear, the diameter of the upper sub- gear of the first double-deck horizontal gear are greater than
The diameter of lower sub- gear, lower sub- gear are engaged with driving gear；The diameter of the upper sub- gear of the second double-deck horizontal gear is less than lower son
The diameter of gear, the upper sub- gear of the first double-deck horizontal gear are engaged with the lower sub- gear of the second double-deck horizontal gear, and second is double-deck flat
The upper sub- gear of gear is engaged with transmission gear.
4. sealing agent spray area detection device according to claim 1, it is characterised in that: the aperture in the spraying hole is
The Material Processing of 5-20mm, the bracket, medicine mixer baffle and sealing agent receiver board are uniform, are rigid plastics or made of metal
At.
5. a kind of detection method of sealing agent spray area, based on sealing agent spray-coating surface described in claim 1-4 any one
Product detection device, it is characterised in that: described method includes following steps:
S1: simultaneously trial operation inspection is spare for the assembling of sealing agent spray area detection device；
S2: sealing agent is configured according to sealing agent operation instruction, configured sealing agent is injected into spare in medicine mixer；
S3: taking a support chip to be placed on sealing agent receiver board, and medicine mixer is placed on medicine mixer baffle, medicine mixer outlet alignment spray
Tu Kong, open control mechanism adjust driving motor speed, and then drive telescopic rod to stretch out by drive screw, push medicine mixer
Push rod, sealing agent spray on support chip, spraying finish to be sealed dose be formed by curing gel after, taken pictures with digital camera, use
Image J software calculates spray area.
6. the detection method of sealing agent spray area according to claim 5, it is characterised in that: the support chip is clean
Blank sheet of paper or sheet glass or plastic sheet.
7. the detection method of sealing agent spray area according to claim 5, it is characterised in that: the sealing agent is Progel
Sealing agent, Coseal sealing agent, DuraSeal sealing agent, Adherus sealing agent, Ocuseal sealing agent, BioGlue surgery hand
Any one in art adhesive, tissue adhesive, seralbumin gel and hemostat.
8. the detection method of sealing agent spray area according to claim 7, it is characterised in that: the seralbumin gel
The preparation method is as follows:
(1) prepare the first liquid component: by seralbumin be dissolved in pH range be 6.0-10.0 buffer solution in prepare obtain it is dense
Degree is the serum albumin solution of 5%-45% (w/v)；
(2) prepare second liquid component: the hydrophilic polymer solid component containing electrophilic functional group, which is dissolved in pH range, is
In the buffer solution of 6.0-10.0, prepares and obtain the hydrophilic polymer containing electrophilic functional group that concentration is 5%~45% (w/v)
Component solution, wherein the seralbumin in the hydrophilic polymer components and the first liquid component containing electrophilic functional group
Mass ratio be 0.3-2；
(3) the first liquid component is mixed with second liquid component, is cross-linked to form seralbumin gel.
9. the detection method of sealing agent spray area according to claim 8, it is characterised in that: the parent containing electrophilic functional group
Waterborne polymeric is selected from double amber imide propionic acid ester group polyethylene glycol, double amber imide succinic acid ester group polyethylene glycol, double
Succinimidyl glutarate base polyethylene glycol, double amber imide decanedioic acid ester group polyethylene glycol, pentaerythrite polyethylene glycol
Four succinimidyl glutarate of ether, four succinimide succinic acid of pentaerythritol polyethylene glycol ether, pentaerythritol polyethylene glycol ether
One of four succinimide decanedioic acid are a variety of, molecular weight 1000-100000.
10. the detection method of sealing agent spray area according to claim 8, it is characterised in that: the seralbumin
Solution is handled via radiation, and irradiation dose range is between 5kGy-45kGy.
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