CN109157536A - A kind of control method of duck plague disease - Google Patents
A kind of control method of duck plague disease Download PDFInfo
- Publication number
- CN109157536A CN109157536A CN201810836909.9A CN201810836909A CN109157536A CN 109157536 A CN109157536 A CN 109157536A CN 201810836909 A CN201810836909 A CN 201810836909A CN 109157536 A CN109157536 A CN 109157536A
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- China
- Prior art keywords
- injection
- duck
- duck plague
- plague disease
- control method
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention provides a kind of control methods of duck plague disease, and this method carries out intramuscular injection using joint injection agent made of acyclovir, rimantadine hydrochloride, dipyrimidinol, to sick duck, rapid-action, and for preventing and treating duck plague disease, effect highly significant, prevention and treatment is simply.
Description
Technical field
The invention belongs to cultural technique fields, and in particular to a kind of control method of duck plague disease
Background technique
Duck, duck are the general designations of Anseriformes Anatidae duck subfamily aquatic bird, mainly with the toy (fish, shrimp, loach etc.) in water,
Plant (water plant, barnyard grass, rice etc.) is food.It is divided into laying duck and duckling, duck's egg nutritive value is high, the fatty acid fusing point in duck
It is low, it is easy to digest.Contained B family vitamin and vitamin E are more compared with other meats, are highly resistant to athlete's foot, neuritis and a variety of
Inflammation, moreover it is possible to anti-aging.Contain niacin more abundant in duck, it be constitute two kinds of important coenzyme in human body at point it
One, there is protective effect to heart disease patients such as myocardial infarctions.
Duck plague (Duck plape0) also known as duck viral enteritis (Duck virusenteritis, DVE), be duck, goose and
A kind of acute, hot, Septic blood infectious disease of other Anseriformes birds.The disease is characterized in prevalence extensively, propagates morbidity rapidly
Rate and the death rate are all high.This disease is found for the first time in Holland early in nineteen twenty-three BaudetShi, until BosShi in 1940 is put forward for the first time duck
The title of pest, and confirm it is a kind of new virus disease different from checken pest.Currently, there is no specific drug, often aim at prevention, except carrying out
Outside biological safety measure, the occurrence of this disease can effectively be prevented by carrying out immunity inoculation using duck plague attenuated live vaccines.Duck mass-sending
When sick, to healthy duck group or suspected infection duck, 3-4 times of amount of duck plague vaccine should be taken promptly to be inoculated with immediately；To sick duck, every
The duck plague hyper-immune serum duck poison of the great high-tech of intramuscular injection state is 0.5 milliliter or 0.5-1 milliliters of poly IC anti-, injects 1 time within every 3 days, 2-3 is used in conjunction
It is secondary, carry out early treatment.The mixed drink of water can also be mixed with Moroxydine Hydrochloride soluble powder or Enrofloxacin soluble powder, it is l-2 times daily,
It is used in conjunction 3-5 days, but is not applied to laying ducks, meat duck is pre-sales should to be discontinued 8 days.The same slaughter of sick duck and buried processing.It is right simultaneously
The all goods that sick duck may contact carry out thorough disinfection.But above-mentioned therapeutic effect is to be improved, and medicament residue is caused to pollute,
It is unfavorable for the production of duck product.
Summary of the invention
Of the existing technology to overcome the problems, such as, the present invention provides a kind of control method of duck plague disease, this method is used
Acyclovir, rimantadine hydrochloride, joint injection agent made of dipyrimidinol carry out intramuscular injection to sick duck, rapid-action,
For preventing and treating duck plague disease, effect highly significant, prevention and treatment is simply.
Specifically, the present invention provides a kind of control methods of duck plague disease, comprising the following steps:
(1) preparation of duck plague disease injection: take acyclovir 1-4g, rimantadine hydrochloride 1-4g, dipyrimidinol 2-6g,
It is put into injection water 600-800ml, holding temperature is 60-70 DEG C of stirring and dissolving, hyperfiltration, the hydroxide of 0.5mol/L
It is 7.0-7.5 that sodium solution, which adjusts PH, and encapsulating sterilizes 30 minutes through 115 DEG C, pressure 0.2MPa, and every 5ml obtains injection；
(2) treatment of duck plague disease: illness duck is rejected into isolation treatment, gives injection injection 2-5ml of the present invention.
(3) duck plague disease is prevented: to sick duck is not suffering from, only being prevented using injection intramuscular injection 1-3ml/ of the invention.
Further, acyclovir 2-3g, rimantadine hydrochloride the preparation of the step (1) duck plague disease injection: are taken
2-3g, dipyrimidinol 3-5g, it is put into injection water 650-750ml, holding temperature is 60-70 DEG C of stirring and dissolving, ultra micro
Filtering, it is 7.0-7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating sterilizes 30 minutes through 115 DEG C, pressure 0.2MPa,
Every 5ml, obtains injection；
Still further, the preparation of (1) duck plague disease injection: taking acyclovir 2.5g, rimantadine hydrochloride
2.5g, dipyrimidinol 4g, be put into injection water 700ml, holding temperature be 65 DEG C of stirring and dissolvings, hyperfiltration,
It is 7.0-7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating sterilizes 30 minutes, every through 115 DEG C, pressure 0.2MPa
5ml obtains injection；
The injection PH is preferably adjusted to 7.3；
The treatment of described step (2) the duck plague disease: illness duck is rejected into isolation treatment, gives injection injection of the present invention
3.5ml。
Step (3) the duck plague disease prevention: to sick duck is not suffering from, only using injection intramuscular injection 2ml/ of the invention
Prevention.
The invention has the benefit that
The method of the present invention is using joint injection agent made of acyclovir, rimantadine hydrochloride, dipyrimidinol, to sick duck
Intramuscular injection is carried out, rapid-action, for preventing and treating duck plague disease, effect highly significant, prevention and treatment is simply.Cure rate is up to 91%, in advance
It is anti-efficient up to 99%.
Specific embodiment
Below with reference to preferred embodiment, the present invention is further explained.It should be understood that these embodiments are merely to illustrate
The present invention rather than limit the scope of the invention.In addition, it should also be understood that, after reading the contents of the present invention, this field
Technical staff can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims
Limited range.
The preparation of 1 duck plague disease injection of embodiment
It takes acyclovir 1g, rimantadine hydrochloride 1g, dipyrimidinol 2g, be put into injection water 600ml, heat preservation temperature
Degree is 60 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.0 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure
0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 2 duck plague disease injection of embodiment
It takes acyclovir 2g, rimantadine hydrochloride 2g, dipyrimidinol 3g, be put into injection water 650ml, heat preservation temperature
Degree is 60 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.0 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure
0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 3 duck plague disease injection of embodiment
It takes acyclovir 2.5g, rimantadine hydrochloride 2.5g, dipyrimidinol 4g, be put into injection water 700ml, protect
Temperature is 65 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.3 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C,
Pressure 0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 4 duck plague disease injection of embodiment
It takes acyclovir 3g, rimantadine hydrochloride 3g, dipyrimidinol 5g, be put into injection water 800ml, heat preservation temperature
Degree is 70 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure
0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 5 duck plague disease injection of embodiment
It takes acyclovir 4g, rimantadine hydrochloride 4g, dipyrimidinol 5g, be put into injection water 800ml, heat preservation temperature
Degree is 70 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure
0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 6 duck plague disease injection of embodiment
It takes acyclovir 2.5g, rimantadine hydrochloride 2.5g, be put into injection water 700ml, holding temperature is 65 DEG C
Stirring and dissolving, hyperfiltration, it is 7.3 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating is gone out through 115 DEG C, pressure 0.2MPa
Bacterium 30 minutes, every 5ml obtained injection；
The preparation of 7 duck plague disease injection of embodiment
It takes rimantadine hydrochloride 2.5g, dipyrimidinol 4g, be put into injection water 700ml, holding temperature is 65 DEG C
Stirring and dissolving, hyperfiltration, it is 7.3 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating is gone out through 115 DEG C, pressure 0.2MPa
Bacterium 30 minutes, every 5ml obtained injection；
The duck plague injection control efficiency of the present invention of test example 1 is investigated
800 duck plague sick ducks are randomly divided into 8 groups, test group 1-7 uses injection made from 1-7 of the embodiment of the present invention respectively
It is treated, control group is treated using anti-0.5 milliliter of duck plague hyper-immune serum duck poison of the great high-tech of intramuscular injection state；Investigate result such as
The following table 1:
The duck plague injection control efficiency of the present invention of table 1 is investigated
It is above-mentioned experiments have shown that, the present invention made of injection for prevent and treat duck plague disease, effect is preferable, and treatment cost is low,
It is easily operated.
Claims (6)
1. a kind of control method of duck plague disease, which comprises the following steps:
(1) it the preparation of duck plague disease injection: takes acyclovir 1-4g, rimantadine hydrochloride 1-4g, dipyrimidinol 2-6g, be put into
For injection in water 600-800ml, holding temperature is 60-70 DEG C of stirring and dissolving, and the sodium hydroxide of hyperfiltration, 0.5mol/L is molten
It is 7.0-7.5 that liquid, which adjusts PH, and encapsulating sterilizes 30 minutes through 115 DEG C, pressure 0.2MPa, and every 5ml obtains injection；
(2) treatment of duck plague disease: illness duck is rejected into isolation treatment, gives injection injection 2-5ml of the present invention；
(3) duck plague disease is prevented: to sick duck is not suffering from, only being prevented using injection intramuscular injection 1-3ml/ of the invention.
2. the control method of duck plague disease according to claim 1, it is characterised in that: the system of step (1) duck plague disease injection
It is standby: it takes acyclovir 2-3g, rimantadine hydrochloride 2-3g, dipyrimidinol 3-5g, be put into injection water 650-750ml,
Holding temperature is 60-70 DEG C of stirring and dissolving, and hyperfiltration, it is 7.0-7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, is filled
Envelope sterilizes 30 minutes through 115 DEG C, pressure 0.2MPa, and every 5ml obtains injection.
3. the control method of duck plague disease according to claim 1 or 2, it is characterised in that: (1) system of duck plague disease injection
It is standby: it takes acyclovir 2.5g, rimantadine hydrochloride 2.5g, dipyrimidinol 4g, be put into injection water 700ml, heat preservation temperature
Degree is 65 DEG C of stirring and dissolvings, hyperfiltration, and it is 7.0-7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C,
Pressure 0.2MPa sterilizes 30 minutes, and every 5ml obtains injection.
4. the control method of duck plague disease according to claim 1, it is characterised in that: injection PH tune described in step (1)
Section is 7.3.
5. the control method of duck plague disease according to claim 1, it is characterised in that: the treatment of step (2) duck plague disease: will suffer from
Sick duck rejects isolation treatment, gives injection injection 3.5ml of the present invention.
6. the control method of duck plague disease according to claim 1, it is characterised in that: step (3) duck plague disease prevention: to being not suffering from
Sick duck, is only prevented using injection intramuscular injection 2ml/ of the invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810836909.9A CN109157536A (en) | 2018-07-26 | 2018-07-26 | A kind of control method of duck plague disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810836909.9A CN109157536A (en) | 2018-07-26 | 2018-07-26 | A kind of control method of duck plague disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109157536A true CN109157536A (en) | 2019-01-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810836909.9A Withdrawn CN109157536A (en) | 2018-07-26 | 2018-07-26 | A kind of control method of duck plague disease |
Country Status (1)
| Country | Link |
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| CN (1) | CN109157536A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580094A (en) * | 2012-02-24 | 2012-07-18 | 赵双印 | Medicine for treating fowl plague and duck plague |
| WO2012106509A1 (en) * | 2011-02-02 | 2012-08-09 | The Trustees Of Princeton University | Sirtuin modulators as virus production modulators |
| CN107308324A (en) * | 2017-06-29 | 2017-11-03 | 贞丰县食源特种养殖有限公司 | A kind of traditional Chinese medicine injection for treating duck plague disease and preparation method thereof |
-
2018
- 2018-07-26 CN CN201810836909.9A patent/CN109157536A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012106509A1 (en) * | 2011-02-02 | 2012-08-09 | The Trustees Of Princeton University | Sirtuin modulators as virus production modulators |
| CN102580094A (en) * | 2012-02-24 | 2012-07-18 | 赵双印 | Medicine for treating fowl plague and duck plague |
| CN107308324A (en) * | 2017-06-29 | 2017-11-03 | 贞丰县食源特种养殖有限公司 | A kind of traditional Chinese medicine injection for treating duck plague disease and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 史万玉: "中兽药在家禽疾病防控中的应用", 《兽医导刊》 * |
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Application publication date: 20190108 |