CN109157190B - Implanted intraocular pressure monitor with protrusion - Google Patents
Implanted intraocular pressure monitor with protrusion Download PDFInfo
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- CN109157190B CN109157190B CN201811315131.3A CN201811315131A CN109157190B CN 109157190 B CN109157190 B CN 109157190B CN 201811315131 A CN201811315131 A CN 201811315131A CN 109157190 B CN109157190 B CN 109157190B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
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Abstract
The present invention provides a kind of intraocular pressure monitors of band protrusion comprising: seal cavity, end have the deformation film for following the intensity of pressure to change and generating deformation；Support portion couples with the seal cavity, positions the direction of the deformation film of the seal cavity, the support portion includes base portion and the protrusion from base portion stretching, and the opposite two sides of the protrusion are provided with protrusion；Pressure sensor is arranged in the seal cavity, and the deformation by detecting the deformation film changes to obtain pressure signal；And signal transmitting apparatus, setting are transferred to outside in the support portion, and by the pressure signal from the pressure sensor.It, can directly and precision highland measures intraocular pressure in the intraocular pressure monitor of band protrusion according to the present invention.
Description
The application isOn May 27th, 2017, application No. is201710393827.7, it is entitledImplantation Formula intraocular pressure monitorPatent application divisional application.
Technical field
The present invention relates to a kind of implanted intraocular pressure monitors of band protrusion.
Background technique
Glaucoma is the irreversibility diseases causing blindness to rank first.There are about 60,000,000 glaucoma patients in the whole world at present, wherein
8400000 blindness.In China, 40 years old or more crowd's prevalence of glaucoma about 2.6%, wherein blind rate about 30%.Glaucoma
Pathogenesis is complicated, generally believes and increases related, the raising of pathologic intraocular pressure or fluctuation with intraocular pressure (sometimes referred to as " intraocular pressure ")
Lead to retinal ganglion cells death, optic atrophy, the visual field gradually defect, until total blindness.
Due to most of glaucoma patients in early stage without any symptom, patient often because defect of visual field and before go just
It examines, but visual function damage at this time is very serious.In developed country, there is the glaucoma patient of half not know oneself with green light
Eye；And in developing country, there is up to 90% glaucoma patient to know nothing the disease of oneself.Chinese glaucoma patient
Treatment rate only has 10%~20%, and many patients are to reach an advanced stage just to go to a doctor, increase treatment difficulty and blinding it is general
Rate.Therefore, for being diagnosed as the patient of glaucoma, most effective chronic diseases management strategy is exactly to pass through the treatment such as eye drops or operation
Means reduce intraocular pressure, and keep its stabilization, to slow down and control the progress of impaired vision, retain useful eyesight throughout one's life.
Currently, hospital is most of to measure intraocular pressure using external intraocular pressure detector.Such measurement method includes single-point eye
Pressure measurement and tonometry in 24 hours.Spot measurement includes planishing type and two kinds of pressure-sinking type, needs patient medical in hospital outpatient
When measure.Wherein Goldmann tonometer is generally acknowledged tonometry " goldstandard ".Before patient is sitting in slit-lamp, point fiber crops
Medicine and fluorescein measure.Intraocular pressure is calculated by weight needed for flattening cornea.Therefore measurement intraocular pressure value is by cornea thickness
The influence of the physical signs such as degree, curvature, elasticity, there is some difference with true intraocular pressure value.It is generally believed that corneal thickness increases
20-30m measures the higher 1mmHg of intraocular pressure value.Tonometry in 24 hours, which needs to be hospitalized, to be measured, and every 2-4 hours is primary, and totally 12 times, note
Intraocular fluctuation is recorded, to capture the intraocular pressure high level that outpatient service single-point tonometry fails to capture.Especially for intraocular pressure
Fluctuate more apparent patient, adjustable optimization administration time.
Summary of the invention
However, above-mentioned measurement method requires to complete under the auxiliary of doctor, glaucoma patient can not be in daily life shape
Tonometry is voluntarily carried out under state, therefore can not be obtained in the intraocular pressure data gone to a doctor under intermediate daily life state twice.One
Aspect, for doctor, can not obtain in time patient's intraocular pressure data issue corresponding therapeutic scheme even therapeutic scheme it is wrong,
Therefore, the glaucoma patient in above-mentioned therapeutic modality also all occurs visual function to some extent and is persistently damaged；On the other hand,
For patients, due to lacking Dynamic intraocular pressure data as feedback and excitation, the compliance that cooperation executes therapeutic scheme is non-
It is often low, directly result in further visual field damage progress；Also result in next time go to a doctor when, doctor can not judge visual field damage into
Exhibition is since therapeutic scheme needs are optimized and revised or patient fails to perform effectively therapeutic scheme.
The present invention is completed in view of above-mentioned status, it is intended that providing a kind of intraocular convenient for continuous monitoring
The implanted intraocular pressure monitor of pressure.
For this purpose, the present invention provides a kind of implanted intraocular pressure monitors comprising: a kind of implanted intraocular pressure monitor,
It include: seal cavity, end has the deformation film for following the intensity of pressure to change and generating deformation；Support portion, and it is described close
Cavity connection is sealed, and positions the direction of the deformation film of the seal cavity；Pressure sensor is arranged in the sealing
In cavity, and the deformation by detecting the deformation film changes to obtain pressure signal；And signal transmitting apparatus, setting
Outside is transferred in the support portion, and by the pressure signal from the pressure sensor.
In implanted intraocular pressure monitor according to the present invention, due to the deformation of the sensing intraocular pressure of intraocular pressure monitor
Film can directly contact the tissue fluid in eyes, therefore, can directly measure intraocular pressure.Accordingly, with respect to conventional outside
For mode of the detection of eyeball tension device to measure intraocular pressure, implanted intraocular pressure monitor of the invention can more precisely measure eye
Interior pressure.
In addition, further include processing circuit optionally in implanted intraocular pressure monitor according to the present invention, the place
Pressure sensor described in circuit drives is managed, and the pressure signal obtained by the pressure sensor is handled.As a result, can
The pressure signal that noise is inhibited enough is obtained, to improve the measurement accuracy of intraocular pressure.
In addition, in implanted intraocular pressure monitor according to the present invention, optionally, the signal transmitting apparatus receive from
Externally input energy, and the energy is supplied to pressure sensor via the processing circuit.Further optionally, institute
It states signal transmitting apparatus to receive from externally input energy, and the energy is supplied to pressure via the processing circuit and is passed
Sensor.By signal transmitting apparatus, energy can be received from outside, while pressure signal effectively can be transferred to outside.
In addition, the signal transmitting apparatus can be coil.It in this case, can be via wirelessly progress energy and data
Transmission.
In addition, optionally, the pressure sensor is with light in implanted intraocular pressure monitor according to the present invention
The pressure sensor of grid, and the pressure sensor includes laser and photodetector, and the photodetector passes through spy
It surveys and is issued by the laser and passed through the stripe order recognition for the light that the grating interferes to obtain the deformation of the deformation film
Variation, to calculate the pressure signal.In this case, deformation film is obtained by the variation of identification interference striations
Deformation variable quantity, thereby, it is possible to the deformation variable quantities of accurately measure deformation film, to obtain more accurate pressure letter
Number.
In addition, in implanted intraocular pressure monitor according to the present invention, optionally, the pressure sensor and the shape
Internal cavity is formed between change film.
In addition, optionally, the internal cavity is by extending in implanted intraocular pressure monitor according to the present invention
The pipeline of the support portion is connected to outside air.In this case, it can guarantee internal cavity and external air pressure
It keeps in balance, thus, it is possible to inhibit pressure signal drift when measuring intraocular pressure.
In addition, optionally, the seal cavity is cylindrical in implanted intraocular pressure monitor according to the present invention.
In this case, seal cavity can be more easily manufactured
In addition, optionally, the support portion includes being arranged in implanted intraocular pressure monitor according to the present invention
The protrusion stating the base portion of signal transmitting apparatus and stretching out from the base portion, the protrusion are fixed with the seal cavity
Connection.
In addition, optionally, the base portion is in the form of annular discs in implanted intraocular pressure monitor according to the present invention.
In addition, optionally, the support portion, which is additionally provided with, to be used in implanted intraocular pressure monitor according to the present invention
The mounting hole of surgical instrument operation.
In addition, in implanted intraocular pressure monitor according to the present invention, optionally, the distal cannula and the proximal end
Part couples via outer tube.Thereby, it is possible to be coupled distal cannula with proximal part realization by outer tube.
In accordance with the invention it is possible to which direct and precision highland measures intraocular pressure.
Detailed description of the invention
Fig. 1 is to show the three-dimensional structure diagram of implanted intraocular pressure monitor involved in embodiments of the present invention.
Fig. 2 is to show another three-dimensional structure diagram of implanted intraocular pressure monitor involved in embodiments of the present invention.
Fig. 3 is to show implanted intraocular pressure monitor involved in embodiments of the present invention in the implantation position of eyes
Schematic diagram.
Fig. 4 is to show the seal cavity and support portion of implanted intraocular pressure monitor involved in embodiments of the present invention
Isolated structure chart.
Fig. 5 is to show the schematic diagram of internal structure of implanted intraocular pressure monitor shown in FIG. 1.
Fig. 6 is the schematic diagram of the coil of implanted intraocular pressure monitor involved in embodiments of the present invention.
Fig. 7 is to show showing for pressure sensor in implanted intraocular pressure monitor involved in embodiments of the present invention
It is intended to.
Symbol description:
1 ... implanted intraocular pressure monitor, 2 ... eyes, 10 ... seal cavities, 12 ... cavity walls, 14 ... deformation films, 16 ...
Feed through structures 20 ... support portion, 22 ... base portions, 100 ... pressure sensors, 200 ... processing circuits, 16 ... feed-through holes, 300 ... lines
Circle.
Specific embodiment
Hereinafter, explaining the preferred embodiment of the present invention in detail with reference to attached drawing.In the following description, for identical
Component assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, attached drawing is only schematical, the mutual ruler of component
Very little shape of ratio or component etc. can be with actual difference.
Fig. 1 is to show the three-dimensional structure diagram of implanted intraocular pressure monitor involved in embodiments of the present invention.Fig. 2 is
Show another three-dimensional structure diagram of implanted intraocular pressure monitor involved in embodiments of the present invention.Fig. 3 is to show this hair
Schematic diagram of the implanted intraocular pressure monitor in the implantation position of eyes involved in bright embodiment.
As depicted in figs. 1 and 2, implanted intraocular pressure monitor 1 (also referred to as " intraocular pressure monitor 1 ") according to the present invention can be with
It is substantially in T-shaped structure.Intraocular pressure monitor 1 includes seal cavity 10 and the support portion 20 coupled with seal cavity 10.In addition,
Although being in T-shaped structure this embodiment illustrates intraocular pressure monitor 1, present embodiment is not particularly limited intraocular pressure
The shape of monitor 1, such as it is also possible to other shapes structure, such as cylinder, parabolical, pylon shape etc..
In the present embodiment, it can be filled with gas in seal cavity 10, such as is filled with the indifferent gas such as nitrogen, argon gas
Body.In addition, the support portion 20 coupled with seal cavity 10 is (specifically in the case where intraocular pressure monitor 1 is in T-shaped structure
The outer region of support portion 20) outer surface of eyeball can be fitted in.
Intraocular pressure monitor 1 according to the present invention can be implanted at many positions of eyes just directly to measure intraocularly
The intensity of pressure.Implantable position for example including in cornea, anterior chamber, back room, vitreum, retina upper space, upper layer train of thought
Film, suprachoroidal space, secondary conjunctiva, sclera is outer, sclera is interior, eye circumference, trabeculectomy position, trabeculectomy position, or
Cyclodialysis space etc..
In the present embodiment, intraocular pressure monitor 1 can be implanted in the anterior chamber of eyes, and make the deformation of seal cavity 10
Film contact is located at eye inner tissue's liquid of anterior chamber.As an example, Fig. 3 shows the anterior chamber 2a that intraocular pressure monitor 1 is implanted to eyes 2
Situation.In this example, by the way that intraocular pressure monitor 1 to be implanted in the anterior chamber of eyes, so that intraocular pressure monitor 1 can be surveyed directly
Measure the intraocular intensity of pressure.
In some instances, battery (minicell) can be set in intraocular pressure monitor 1 to supply to intraocular pressure monitor 1
Electricity.In addition, can also be powered by the external equipment coupled with intraocular pressure monitor 1 in other examples, such as external electricity
Source passes to intraocular pressure monitor 1 by way of wireless transmission.
In some instances, intraocular pressure can be performed as often as measuring by intraocular pressure monitor 1.It is, for example, possible to use
The hand-held reader (not shown) coupled with intraocular pressure monitor 1 measures.As an example, the hand-held reader can be with
The receiving coil (not shown) for the pressure signal that component and reception with emitted energy are emitted from intraocular pressure monitor 1.
By the hand-held reader, it can both power to intraocular pressure monitor 1, and also can receive the pressure measured by intraocular pressure monitor 1
Signal.
In the present embodiment, the measurement of intraocular pressure can monitor (discontinuous monitoring) in a manner of intermittent, can also be with
(continuous monitoring) is monitored in a manner of continuous (such as enough frequency).Intraocular pressure monitor 1 is read by hand-held reader
Pressure data can determine daily Diurnal IOP curve, to detect peak intraocular pressure and pressure peak.Hand-held reading can be automatic
Ground sends patient's intraocular pressure information obtained to attending physician, to help the intraocular pressure situation of doctor remote monitor patient.
By the direct tonometry data obtained of intraocular pressure monitor 1, there are many benefits.For example, tonometry data can
To trigger alarm to patient, and transmit this data to the office of long-range server or patient attending physician.In addition, hair
The data for being sent to remote server can be analyzed, such as carry out data mining with the statistical trend of determination and analysis.By
This, by these data, doctor can monitor patient's state of an illness in time, to allow patient that can obtain timely and effectively control
It treats.
Referring again to Fig. 3, eyes include sclera and crystalline lens, and crystalline lens makes light refraction and formed in the retina of eyes
Image.Retina includes cone cell and rod cell, can detect light color susceptibility and high visual sensitivity.Retina is also
Including blind spot, optic nerve collects herein and is connected to brain.Iris is located above crystalline lens, in the dark in response to light and
Expansion is but shunk in bright light, and the light intensity being mapped on retina in this way can enhance and weaken respectively.Before eyes include
Portion and rear portion, crystalline lens are just arranged between.Front includes aqueous humor, and rear portion includes vitreum.The rear chamber of eyes prolongs
It is stretched outside between iris and lenticular preceding coating, and including aqueous humor.Front includes the back room.The liquid of eyes is usually from back room
It is discharged into anterior chamber, and is discharged to except schlemm's canal to keep intraocular pressure.
The measurement end (including the end of deformation film) of intraocular pressure monitor 1 can be implanted to the anterior chamber of eyes, supervise intraocular pressure
The front end for surveying device 1 is directly contacted with the tissue fluid in eyes, so that intraocular pressure monitor 1 can directly measure the intraocular pressure of eyes
Power.
In the present embodiment, the size of intraocular pressure monitor 1 is not particularly limited, such as the length of intraocular pressure monitor 1 can
Up to 2~15mm.In addition, the width of the widest part is about 5mm, in this case, can from the viewpoint of the current operation safety
Reduce postoperative complication.
Fig. 4 is to show the seal cavity and support portion of implanted intraocular pressure monitor involved in embodiments of the present invention
Isolated structure chart.Fig. 5 is to show the schematic diagram of internal structure of implanted intraocular pressure monitor shown in FIG. 1.
In the present embodiment, the intensity of pressure is followed to change and produce as shown in figure 4, the end of seal cavity 10 can have
The deformation film 14 of raw deformation.In some instances, the end of seal cavity 10 can be front end, that is, contact with eye inner tissue liquid
One end.
In addition, in some instances, deformation film 14 can be elastic membrane.After intraocular pressure monitor 1 is implanted to specified position,
Deformation film 14 positioned at 10 front end of seal cavity will directly be contacted with the tissue fluid of inside of eye, since deformation film 14 can follow
Intraocular pressure Strength Changes and generate deformation, therefore, by deformation film 14, the intensity of pressure of eye inner tissue's liquid can be obtained.
In the present embodiment, seal cavity 10 can be in substantially cylindric.In addition, seal cavity 10 can be by side wall
12, deformation film 14 and the formation of feed through structures 16.In addition, although present embodiment show seal cavity 10 be it is substantially cylindric,
But seal cavity 10 is also possible to other shapes, such as cuboid or irregular shape etc..
In the present embodiment, side wall 12 can be shaped generally as cyclic structure.Thickness (the i.e. thickness of ring wall of side wall 12
Degree) it is not particularly limited, such as in some instances, the ring wall thickness of side wall 12 is about that 0.3mm or more just can reach good
Support strength, for example, the ring wall thickness of side wall 12 is preferably 0.3mm~1mm.
In addition, in the present embodiment, deformation film 14 can be set in the end of side wall 12, and feed through structures 16 are arranged in side
The other end of wall 12.In addition, for example deformation film 14, side wall 12 and feed through structures 16 can be welded on one by welding
It rises.Here, the mode of welding can be using well known to a person skilled in the art technology such as laser weldings, therefore, in this explanation
It will not be described in great detail in book.
In the present embodiment, side wall 12 can be by selected from titanium and its alloy, noble metal (including gold, silver and platinum group metal
(ruthenium, rhodium, palladium, osmium, iridium, platinum)) and its alloy, medical grade (biograde) stainless steel, tantalum, niobium, Nitinol (Nitinol) or
At least one of nickel cobalt chrome molybdenum (MP35N) is constituted.In addition, side wall 12 preferably can be by titanium or titanium alloy material structure
At.
With reference to Fig. 5, feed through structures 16 can be by ceramic bases 16c and the metal for being filled in feed-through hole 16a and feed-through hole 16b
Column is constituted.In such a case, it is possible to realize the two sides ceramic bases 16c via the gold for being filled in feed-through hole 16a and feed-through hole 16b
Belong to column and it is conductive.
In addition, for the ease of being electrically connected with processing circuit 200 (being described later on), it can also be enterprising in ceramic bases 16c
Row metal patterning.The step of metal pattern on ceramic bases 16c may include metal deposit (deposition) or
The Conventional process steps such as (sputtering), photoetching (lithography), etching (etching) are sputtered, due to these conventional works
Skill step belongs to well-known technique, therefore which is not described herein again.In addition, the metal pattern in ceramic bases 11 can also be adopted
With well known silk-screen printing technique.
As shown in figure 4, being filled with metal column in feed-through hole 16a, 16b.The shape of metal column can respectively with feed-through hole
16a, 16b cooperation.By the way that feed through structures 16 are arranged, to can either ensure the high-air-tightness of seal cavity 10, and can guarantee
The conduction of 16 two sides of feed through structures.
In addition, being provided with pressure sensor 100 and processing circuit 200 in seal cavity 10.Since seal cavity 10 needs
It to be retained in eyes for a long time as implant, therefore the side wall 12 of seal cavity 10, deformation film 14 and feed through structures 16 are each
Part needs directly to contact with the tissue fluid in eyes, faces intracorporal complex physiologic environment.Therefore, the biology of seal cavity 10
Safety is chronically implanted reliability etc. and needs to meet relevant requirement such as ISO 10993 (international standard), GB/T 16886
(Chinese Industrial Standards (CIS)) etc..
In general, in order to ensure intraocular pressure monitor 1 biological safety, be chronically implanted reliability etc., seal cavity 10
On the one hand by abiotic security component in intraocular pressure monitor 1 such as IC chip, printed circuit board (PCB) etc. be implanted portion
Position (such as tissue fluid) isolation；On the other hand, it is drawn and is believed from the seal cavity 10 by feed-through hole 16a, 16b of feed through structures 16
Number interactive function conducting wire.That is, the route of seal cavity 10 is drawn out to signal via feed-through hole 16a, 16b of feed through structures 16
Transmitting device (being coil 300 here) (referring to Fig. 6).
As shown in Figure 3 and Figure 4, support portion 20 couples with seal cavity 10.Support portion 20 may include base portion 22 and from base
The protrusion 24 that portion 22 is stretched out.In addition, base portion 22 for example can be in the form of annular discs, protrusion 24 is in substantially cylindric.In addition, protrusion
It portion 24 can be in opposite two sides along raised 24a, 24b (referring to Fig. 4) of implantation direction arrangement.In this case, due to
The two sides of protrusion 24 are provided with raised 24a and protrusion 24b, therefore can be easier to make the notch of eyeball surface (sclera is cut
Mouthful) such as watertight naturally, thus it is more advantageous to the suture of operation mouth.
In addition, signal transmitting apparatus can be set in base portion 22.In the present embodiment, signal transmitting apparatus can be
Coil 300 (referring to Fig. 5).Coil 300 can be via feed through structures 16 (specifically via feed-through hole 16a, 16b) and processing circuit
200 connections.
In addition, Fig. 6 is the schematic diagram of the coil 300 of implanted intraocular pressure monitor involved in embodiments of the present invention.
As shown in fig. 6, coil 300 can receive as receiving antenna from externally input energy, can also be monitored from setting in intraocular pressure
Battery (not shown) inside device 1 obtains energy.Coil 300 is as transmitting antenna by the pressure from pressure sensor 100
Signal is transferred to outside.In other words, the pressure signal from pressure sensor 100 is via 10 (specifically seal chamber of seal cavity
The feed through structures 16 of body) and it is transferred to the coil 300 of support portion 20.Here, feed-through hole 16a, 16b and coil of feed through structures 16
Connecting line 420,440 be electrically connected.By coil 300, effectively intraocular pressure signal can be transferred to outside eye, simultaneously will
Energy transmission outside eye gives intraocular intraocular pressure monitor 1, and thus, it is possible to realize the monitoring of convenient intraocular pressure.
In the present embodiment, pressure sensor 100 can be couple to external reading via processing circuit 200, coil 300
Take device (not shown).Here, external reader can determine disease according to the intraocular pressure and outside atmospheric pressure that directly measure
The intraocular pressure of people.Since atmospheric pressure can fluctuate within the scope of about ± 10mmHg, and can also with the height above sea level of patient and
Become, thus it is obtained final according to being determined by the atmospheric pressure outside the intraocular pressure obtained of intraocular pressure monitor 1 and eyes
Intraocular pressure, thus, it is possible to significantly improve report to the accuracy of the intraocular pressure of doctor and patient.
External reader can for example determine the intraocular pressure of patient according to the intraocular pressure and atmospheric pressure that directly measure.For example,
External reader may include barometric pressure sensor, so as to intraocular pressure and the locality directly measured according to pressure sensor 100
Atmospheric pressure is reported to determine to the intraocular pressure of doctor and patient.Optionally, external reader also can include determining that patient's geography
The special circuit of position, and patient present position can be determined using patient location information according to meteorological Weather information
Pressure.The geographical position coordinates of patient can be by mobile phone or global positioning system (GPS) electricity with external reader
Road is positioned.
It is well known that atmospheric pressure can be fluctuated with Changes in weather and slowly, and in the about magnitude of ± 10mmHg.?
In this case, to correction made by the patient's intraocular pressure measured, essence can be provided according to weather information in data processing stage
True higher intraocular pressure value.In addition, the position by determining patient, can determine atmospheric pressure relevant to height above sea level where patient
Fluctuation, and be used to determine the intraocular pressure of patient.For example, subtracting the big of patient position and height above sea level from the intraocular pressure directly measured
Atmospheric pressure, to determine that report to the intraocular pressure of doctor and patient corrected, thus can determine report to the intraocular pressure of doctor and patient.
Fig. 7 is to show showing for pressure sensor in implanted intraocular pressure monitor involved in embodiments of the present invention
It is intended to.Pressure sensor 100 is arranged in seal cavity 10 and close to deformation film, and pressure sensor 100 passes through detection deformation
The deformation of film changes to obtain pressure signal.Internal cavity 16 is formed between pressure sensor 100 and deformation film 14.
In the present embodiment, the pressure sensor with grating can be used in pressure sensor 100.Specifically, pressure
Force snesor 100 includes substrate 110, grating 120 and the laser 150 and light being arranged between substrate 110 and grating 120
Electric explorer 130.Laser 150 projects laser L relative to substrate 110 at an angle.Grating 120 is translucent grating
Structure, material are not particularly limited.Some is penetrated grating 120 by the laser for being incident on grating 120 as a result, there is one
Shunt excitation light is reflected by grating 120.
As shown in fig. 7, in some instances, the laser L emitted by laser 150 advances along the direction of shown by arrow.
Diffraction occurs after encountering grating 120 by laser L and transmission, some laser L are reflected by grating 120, some laser L is direct
Through grating 120.And it is captured by reflecting by photodetector 130.The reflection of film 14 is distorted through the laser of grating 120
Back.The laser of this two parts reflection will interfere, and the light distribution of interference light is detected by photodetector 130.Due to
Deformation film 14 can follow intraocular pressure Strength Changes and generate deformation, therefore, in above-mentioned optical diffraction and interventional procedures, two
Shunt excitation light, which is formed by interference fringe, to be changed.Since different interference fringes corresponds to different light distribution, photodetection
The light intensity that device 130 is detected is also different.As a result, by the relationship of analysis intraocular pressure and luminous intensity, thus, it is possible to obtain intraocular pressure
The intensity of pressure.
In the present embodiment, the energy of laser 150 can be provided by the battery being arranged in intraocular pressure monitor 1,
Energy can be obtained from outside by coil 300.Such as Vcsel can be used in laser 150.It is this
Laser can launch the laser on the surface perpendicular to laser, therefore, use Vcsel, Neng Gourong
It changes places and controls the injection direction of laser.Here, photodetector 130 can be set multiple, such as two.
In the present embodiment, protrusion 24 can be fixedly connected with seal cavity 10 (referring to Fig. 5).In addition, by prominent
Portion 24 is played, the direction of the deformation film 14 of location sealing cavity 10 can be facilitated.
In addition, in the present embodiment, processing circuit 200 can be with driving pressure sensor 100, and to by pressure sensing
The pressure signal that device 100 obtains is handled.Processing circuit 200 can include example by making on printed circuit board (PCB)
Such as resistor, capacitor or inductor discrete component or IC chip (IC) such as specific integrated circuit
(ASIC), programmable logic circuit (FPGA), electricallyerasable ROM (EEROM) (EEPROM) etc. and constitute.In addition, processing circuit
200 are also possible to other function component, as long as can satisfy specific implantation with desired function.In addition, processing circuit
200 can be formed by PCB layer is folded.Thus, it is possible to effectively reduce the occupied area of processing circuit 200.
In the present embodiment, processing circuit 200 such as can play to input signal, stimulus signal or detection signal
Various signals carry out the effect of signal processing.
In addition, internal cavity 16 can also be made by extending to support portion in order to improve the measurement accuracy of intraocular pressure monitor 1
20 pipeline (not shown) is connected to outside air.Since internal cavity 16 is connect by pipeline with outside air, it can
Reduce measurement error caused by external air pressure changes, improves the measurement accuracy of intraocular pressure monitor 1.
Pressure sensor 100 involved in present embodiment can be made by the method for MEMS (MEMS)
It makes.For example, pressure sensor 100 may include the monolithic sensor supported with substrate (such as substrate of glass).Optionally, pressure
Sensor 100 also may include mixed type sensor, have the flexible substrates for being supported on such as flexible printed circuit board (PCB)
On pressure sensor for micro electro-mechanical system, e.g. polyimide flex printed circuit board.
The method that intraocular pressure monitor 1 is implanted into glasses is not particularly limited.For example, packaged intraocular pressure can be monitored
Device 1 is placed into casing, and intraocular pressure monitor 1 is sent to implant site such as anterior chamber close to applying tired Mu Shi by means of delivery
The position of pipe.
In some instances, in support portion 20, it is additionally provided with the mounting hole 22a for surgical instrument operation.For example, logical
The means of delivery for crossing ophthalmologic operation is chimeric with mounting hole 22a, so as to be implanted into intraocular pressure monitor 1 by means of delivery
To predetermined portion such as anterior chamber.Means of delivery size is suitable for receiving intraocular pressure monitor 1.
Although combining drawings and embodiments to illustrate the present invention above, it is not intended to limit
The present invention, it should be understood that those skilled in the art, without departing from the spirit and scope of the present invention, can
To deform and change to the present invention, these deformations and change are each fallen in scope of the claimed protection of the invention.
Claims (10)
1. a kind of intraocular pressure monitor of band protrusion, it is characterised in that:
Include:
Seal cavity, end have the deformation film for following the intensity of pressure to change and generating deformation；
Support portion couples with the seal cavity, positions the direction of the deformation film of the seal cavity, the support portion
Including base portion and the protrusion stretched out from the base portion, and the opposite two sides of the protrusion are provided with protrusion；
Pressure sensor is arranged in the seal cavity, and the deformation by detecting the deformation film changes to obtain
Pressure signal；And
Signal transmitting apparatus is arranged in the support portion, and by the pressure signal from the pressure sensor
It is transferred to outside.
2. intraocular pressure monitor as described in claim 1, it is characterised in that:
It further include processing circuit, the processing circuit drives the pressure sensor, and obtains to by the pressure sensor
Pressure signal handled.
3. intraocular pressure monitor as claimed in claim 2, it is characterised in that:
The signal transmitting apparatus reception is supplied to from externally input energy, and by the energy via the processing circuit
Pressure sensor.
4. intraocular pressure monitor as described in claim 1, it is characterised in that:
The pressure sensor is the pressure sensor with grating, and
The pressure sensor includes laser and photodetector, and the photodetector is sent out by detecting by the laser
The stripe order recognition of the light interfered out and by the grating changes to obtain the deformation of the deformation film, described to calculate
Pressure signal.
5. intraocular pressure monitor as described in claim 1, it is characterised in that:
Internal cavity is formed between the pressure sensor and the deformation film.
6. intraocular pressure monitor as claimed in claim 5, it is characterised in that:
The support portion has the pipeline being connected to outside air,
The internal cavity is connected to by extending to the pipeline with outside air.
7. intraocular pressure monitor as described in claim 1, it is characterised in that: the seal cavity is cylindrical.
8. intraocular pressure monitor as described in claim 1, it is characterised in that: the protrusion and the fixed connection of the seal cavity
It connects.
9. intraocular pressure monitor as described in claim 1, it is characterised in that: the base portion is in the form of annular discs.
10. intraocular pressure monitor as described in claim 1, it is characterised in that: the support portion is additionally provided with for surgical instrument
The mounting hole of operation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610362589 | 2016-05-27 | ||
| CN2016103625899 | 2016-05-27 | ||
| CN201710393827.7A CN107432733B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710393827.7A Division CN107432733B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor |
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| CN109157190A CN109157190A (en) | 2019-01-08 |
| CN109157190B true CN109157190B (en) | 2019-10-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710393827.7A Active CN107432733B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor |
| CN201811315131.3A Active CN109157190B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor with protrusion |
| CN201811315050.3A Active CN109157189B (en) | 2016-05-27 | 2017-05-27 | Implantable pressure monitor |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710393827.7A Active CN107432733B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811315050.3A Active CN109157189B (en) | 2016-05-27 | 2017-05-27 | Implantable pressure monitor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114532976A (en) | 2016-05-31 | 2022-05-27 | 酷拉公司 | Implantable intraocular pressure sensor and method of use |
| WO2020232015A1 (en) * | 2019-05-13 | 2020-11-19 | Verily Life Sciences Llc | Systems, devices and methods for optical interrogation of an implantable intraocular pressure sensor |
| CN114569063B (en) * | 2022-04-24 | 2022-08-19 | 明澈生物科技(苏州)有限公司 | Intraocular pressure sensor |
| CN115054201A (en) * | 2022-06-21 | 2022-09-16 | 山东大学 | In-situ on-line intraocular pressure monitoring device and working method |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050159660A1 (en) * | 2002-05-31 | 2005-07-21 | Valentino Montegrande | Intraocular pressure sensor |
| US8123687B2 (en) * | 2009-05-07 | 2012-02-28 | Alcon Research, Ltd. | Intraocular pressure sensor |
| IN2012DN03211A (en) * | 2009-09-18 | 2015-10-23 | Orthomems Inc | |
| CN101766473B (en) * | 2010-02-09 | 2011-09-07 | 北京大学人民医院 | System for monitoring intraocular pressure |
| WO2012137067A2 (en) * | 2011-04-07 | 2012-10-11 | Oculox Technology | Intraocular pressure monitoring device and methods |
| US20140296688A1 (en) * | 2011-06-06 | 2014-10-02 | The Hong Kong University Of Science And Technology | Surface deformation sensor |
| CN102589446A (en) * | 2012-03-06 | 2012-07-18 | 浙江大学 | High precision micro-displacement measurement apparatus and method |
| EP3003218A2 (en) * | 2013-05-28 | 2016-04-13 | Ico, Inc. | Intraocular lens peripheral surgical systems |
| CN204064535U (en) * | 2014-05-15 | 2014-12-31 | 上海舜宇海逸光电技术有限公司 | Pressure transducer |
| EP4242614A3 (en) * | 2014-07-01 | 2023-11-29 | Injectsense, Inc. | Hermetically sealed implant sensors with vertical stacking architecture |
| WO2016004262A1 (en) * | 2014-07-01 | 2016-01-07 | Cao Ariel | Ultra low power charging implant sensors with wireless interface for patient monitoring |
| CN105054893B (en) * | 2015-07-17 | 2017-03-15 | 上海市同济医院 | Intraocular pressure monitor and system for monitoring intraocular pressure |
-
2017
- 2017-05-27 CN CN201710393827.7A patent/CN107432733B/en active Active
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| CN107432733A (en) | 2017-12-05 |
| CN107432733B (en) | 2019-08-20 |
| CN109157189A (en) | 2019-01-08 |
| CN109157189B (en) | 2020-04-10 |
| CN109157190A (en) | 2019-01-08 |
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