CN109143133B - Method for improving contrast of low signal shadow around gadoxetic acid disodium liver and gall specific liver cancer and magnetic resonance equipment - Google Patents
Method for improving contrast of low signal shadow around gadoxetic acid disodium liver and gall specific liver cancer and magnetic resonance equipment Download PDFInfo
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Abstract
The invention relates to a method and a magnetic resonance device for improving the contrast of a low signal image around gadoxetic acid disodium liver and gall specific liver cancer. The method comprises the following steps: for the liver cancer individual injected with gadoxetate disodium contrast agent, performing magnetic resonance examination, and scanning after breath holding by using the following sequence: 1.5T magnetic resonance scanner, in the specific period of the liver and gallbladder (20 minutes after gadoxetic acid disodium contrast agent injection), the breath-hold fat inhibition T1WI three-dimensional gradient echo volume interpolation breath-hold examination sequence, scanning parameters: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 °; the number of excitations is 1. The radio frequency pulse emitted by the magnetic resonance equipment enables the flip angle to be 23 degrees all the time. The invention selects a proper scanning sequence for the liver cancer patient, and can quickly and efficiently obtain images with low signal shadow and high contrast.
Description
Technical Field
The invention relates to the technical field of imaging diagnosis, in particular to a method and a magnetic resonance device for improving the contrast of a low-signal image around gadoxetic acid disodium liver-gall specific-stage liver cancer.
Background
At present, the sequence used for liver-gallbladder specific phase magnetic resonance imaging after gadoxetate disodium contrast agent injection is as follows: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium injection for 20 minutes (liver and gall specific period), performing breath-holding fat inhibition T1WI three-dimensional gradient echo volume interpolation breath-holding examination sequence, and scanning parameters: TR is 4.36 ms; TE is 2 ms; BW 400; matrix: 320 x 240; the flip angle is as follows: 10 degrees; the number of excitations is 1. However, the sequence shows that the contrast of the low-signal image around the liver cancer is poor, the scanning success rate is low, and the workload of a magnetic resonance doctor and a technician is increased.
Patent document CN102670203A, published Japanese 2012.09.19, discloses a low-field magnetic resonance brain conventional sequence fast scanning method, the method is SE/FSE sequences T1WI and T2WI brain, the FOV axis is 33cm, the layer thickness is 5-8 cm, next 1 time; the FOV sagittal coronal position is 35cm, the thickness of the layer is 4-5 cm, and the next time is 1. The method has the advantages that: the scanning time of each sequence is obviously reduced to 1/4, and 7 hours in a working day is increased from 15 times of original examination to 30 times of rest persons; because the scanning is fast, the total artifact is obviously reduced, the scanning success rate is high, and the sequence rescanning rate is reduced to less than 3 per thousand from the original 2 percent; because of the adoption of large-view scanning, more than 2 ten thousand images can display lesions which cannot be seen in the conventional view, and therefore, the cost performance is extremely high.
However, no magnetic resonance method and device capable of remarkably improving the contrast of the low signal contrast around the gadoxetic acid disodium liver-gall specific-stage liver cancer are available at present.
The magnetic resonance sequence is an organic combination of radio frequency pulses and gradient pulses with a certain bandwidth and a certain amplitude. The sequence parameters comprise time parameters such as repetition time and echo time, resolution parameters such as a scanning matrix, a flip angle, excitation times and the like. Wherein the macroscopic magnetization vector M will deviate from the static magnetic field B under excitation by RF pulses0The angle of deviation is called the flip angle. The magnitude of the flip angle is determined by the intensity (energy) of the excitation electromagnetic wave, and the flip angle can be increased by increasing the intensity or width of the RF pulse. Commonly used flip angles are two, 180 ° and 90 °, referred to as 180 ° and 90 ° pulses, respectively. In a fast imaging sequence such as gradient echo, a small angle (low flip angle) excitation technology is often adopted, and the recovery time of the system is short, so that the imaging speed can be effectively improved.
In order to more quickly and effectively display low signal images around the liver cancer, reduce the workload of magnetic resonance doctors and technicians and save time, a more effective magnetic resonance sequence needs to be searched.
Disclosure of Invention
The invention aims to provide a method and a magnetic resonance device for improving the contrast of a low signal image around gadoxetic acid disodium liver and gall specific liver cancer, aiming at the defects in the prior art.
In a first aspect, the present invention provides a method for increasing the contrast of low signal contrast around gadoxetate disodium liver-gall specific liver cancer, comprising the steps of: for the liver cancer individual injected with gadoxetate disodium contrast agent, performing magnetic resonance examination, and scanning after breath holding by using the following sequence: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium contrast agent for 20 minutes in the liver and gall specific period, the breath-holding fat inhibits the volume interpolation breath-holding check sequence of T1WI three-dimensional gradient echo, and the scanning parameters are as follows: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 °; the number of excitations is 1.
In a second aspect, the present invention provides a method for increasing the contrast of low signal contrast around gadoxetate disodium hepatobiliary specific liver cancer for non-diagnostic purposes, comprising the steps of: aiming at the liver cancer individual injected with the gadoxetic acid disodium injection, performing magnetic resonance examination, and scanning by using the following sequence after breath holding: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium contrast agent for 20 minutes in the liver and gall specific period, the breath-holding fat inhibits the volume interpolation breath-holding check sequence of T1WI three-dimensional gradient echo, and the scanning parameters are as follows: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 °; the number of excitations is 1.
In a third aspect, the invention provides a magnetic resonance device for improving the contrast of low-signal images around the gadoxetic acid disodium liver-gall specific-stage liver cancer, wherein the magnetic resonance device is provided with a radio frequency generator, and a radio frequency pulse emitted by the radio frequency generator enables the flip angle to be 23 degrees all the time.
As a preferred example, the magnetic resonance apparatus is configured to implement the following sequence: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium contrast agent for 20 minutes in the liver and gall specific period, the breath-holding fat inhibits the volume interpolation breath-holding check sequence of T1WI three-dimensional gradient echo, and the scanning parameters are as follows: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 °; the number of excitations is 1.
As another preferred example, the magnetic resonance apparatus is provided with a main magnet system, a gradient system, a radio frequency system, a system control and data processing computer.
Preferably, the system control and data processing computer comprises a hardware control module, a system adjustment module, an image processing module and a file management module.
Preferably, the hardware control module is used for controlling hardware working parameters of the gradient system and the radio frequency system, and is provided with a flip angle control submodule which is used for controlling the radio frequency pulse sent by the radio frequency generator to enable the flip angle to be 23 degrees all the time.
Preferably, the gradient system comprises a gradient coil, a gradient amplifier, a digital-to-analog converter, a gradient controller and a gradient cooling device.
Preferably, the radio frequency system comprises a radio frequency generator, a radio frequency amplifier, a radio frequency coil and a radio frequency receiver.
The invention has the advantages that:
based on abundant experience, the inventor of the present application realizes that the flip angle is an important imaging parameter commonly used in magnetic resonance enhanced scanning, and because the shortest TR is used in GRE T1WI, and the fitting degree in longitudinal magnetization recovery is still incomplete, image signals with higher quality are obtained, and the influence of adjusting the flip angle on the image signals is significant. The gadoxetic acid disodium is a novel hepatocyte specific MR contrast agent, a low flip angle value is preferably selected for a long T1 tissue, a high flip angle value is preferably selected for a short T1 tissue, so that a high flip angle, especially 23 degrees, is selected, the flip angle of a maximum perturbation phase gradient echo signal is obtained, the signal contrast can be increased, the low signal shadow contrast (signal-to-noise ratio and contrast-to-noise ratio) around the liver cancer is obviously improved, the magnetic resonance specificity is improved, an unexpected technical effect is obtained, and the contrast is obviously superior to scanning under other flip angles. The method is beneficial to quickly and efficiently obtaining the magnetic resonance image of the liver cancer patient, reducing the burden of medical staff and also beneficial to scientific research on the relationship between the magnetic resonance image of the liver cancer patient and the prognosis and recurrence of diseases.
Drawings
FIG. 1 is a schematic structural diagram of a magnetic resonance apparatus for improving the contrast of low signal contrast around gadoxetic acid disodium liver-gall idiosyncratic liver cancer according to example 1.
FIG. 2 is a schematic structural diagram of the magnetic resonance apparatus for improving the contrast of the low signal contrast around the gadoxetic acid disodium liver-gall idiosyncratic liver cancer of example 2.
FIG. 3 is an image of two MR examinations of a patient with liver cancer in example 3.
FIG. 4 is a graph showing the contrast calculation of the low signal contrast around the tumor in the two MR examinations of the patient with liver cancer in example 3.
Detailed Description
The following detailed description of the present invention will be made with reference to the accompanying drawings.
The reference numerals and components referred to in the drawings are as follows:
1. main magnet system 2 gradient system
21. Gradient coil 22 gradient amplifier
23. Digital-to-analog converter 24 gradient controller
25. Gradient cooling device 3. radio frequency system
31. RF generator 32, RF amplifier
33. Radio frequency coil 34, radio frequency receiver
4. System control and data processing computer 41 hardware control module
411. Roll-over angle control submodule 42, system adjustment module
43. Image processing module 44, file management module
5. Working table 6, movable examining table
EXAMPLE 1 magnetic resonance apparatus (I) of the invention
Referring to fig. 1, fig. 1 is a schematic structural diagram of a magnetic resonance apparatus for improving contrast of low signal contrast around gadoxetate disodium liver-gall idiosyncratic liver cancer according to example 1. The magnetic resonance equipment is provided with a main magnet system 1, a gradient system 2, a radio frequency system 3 and a system control and data processing computer 4. The main magnet system 1 is used to generate a magnetic field, wherein the main magnet is a superconducting magnet (1.5T). The gradient system 2 is used for space positioning, generating gradient echo signals, applying a diffusion sensitive gradient field and water molecule imaging, performing flow compensation and performing phase compensation of flowing liquid, and comprises a gradient coil 21, a gradient amplifier 22, a digital-to-analog converter 23, a gradient controller 24 and a gradient cooling device 25. The radio frequency system 3 comprises a radio frequency generator 31, a radio frequency amplifier 32, a radio frequency coil 33 and a radio frequency receiver 34. The system control and data processing computer 4 includes a hardware control module 41, a system adjustment module 42, an image processing module 43 and a file management module 44. The hardware control module 41 is used for controlling hardware working parameters of the gradient system 2 and the radio frequency system 3, the hardware control module 41 is provided with a flip angle control submodule 411, and the flip angle control submodule 411 is used for controlling radio frequency pulses sent by the radio frequency generator 31 to enable the flip angle to be 23 degrees all the time and enable the flip angle to be 23 degrees only. The system adjusting module 42 is used for measuring the resonance frequency of the protons in the center of the magnetic field and setting the operating frequency of the radio frequency generator 31 and the radio frequency receiver 34 at the frequency; tuning the radio frequency coil 33 to resonate at the proton resonance frequency for the imaged body part; the rf output power of the rf generator 31 is determined at which the maximum MR signal can be generated, and the amplification or gain of the signal by the rf receiver 34 is determined based on the amplitude of this MR signal. The image processing module 43 is used for collecting, reconstructing and analyzing images. The file management module 44 is used for performing operations such as archiving a disk file, loading a tape file, and deleting a disk file.
EXAMPLE 2 magnetic resonance apparatus (II) of the invention
Referring to fig. 2, fig. 2 is a schematic structural diagram of the magnetic resonance apparatus for improving the contrast of low signal contrast around gadoxetate disodium liver-gall idiosyncratic liver cancer of example 2. The magnetic resonance apparatus is provided with a main magnet system 1, a gradient system 2, a radio frequency system 3, a system control and data processing computer 4, a worktable 5 and a movable examining table 6. The main magnet system 1 is used to generate a magnetic field, wherein the main magnet is a superconducting magnet (1.5T). The gradient system 2 is used for space positioning, generating gradient echo signals, applying a diffusion sensitive gradient field and water molecule imaging, performing flow compensation and performing phase compensation of flowing liquid, and comprises a gradient coil 21, a gradient amplifier 22, a digital-to-analog converter 23, a gradient controller 24 and a gradient cooling device 25. The radio frequency system 3 comprises a radio frequency generator 31, a radio frequency amplifier 32, a radio frequency coil 33 and a radio frequency receiver 34. The system control and data processing computer 4 includes a hardware control module 41, a system adjustment module 42, an image processing module 43 and a file management module 44. The hardware control module 41 is used for controlling hardware working parameters of the gradient system 2 and the radio frequency system 3, the hardware control module 41 comprises a flip angle control submodule 411, and the flip angle control submodule 411 is used for controlling radio frequency pulses sent by the radio frequency generator 31 to enable the flip angle to be 23 degrees all the time, and only enables the flip angle to be 23 degrees. The system adjusting module 42 is used for measuring the resonance frequency of the protons in the center of the magnetic field and setting the operating frequency of the radio frequency generator 31 and the radio frequency receiver 34 at the frequency; tuning the radio frequency coil 33 to resonate at the proton resonance frequency for the imaged body part; the rf output power of the rf generator 31 is determined at which the maximum MR signal can be generated, and the amplification or gain of the signal by the rf receiver 34 is determined based on the amplitude of this MR signal. The image processing module 43 is used for collecting, reconstructing and analyzing images. The file management module 44 is used for performing operations such as archiving a disk file, loading a tape file, and deleting a disk file. The working table 5 is used for placing a system control and data processing computer 4 to complete imaging operation and image analysis. The movable examining table 6 is used for fixing the body position of the examinee.
It should be noted that the magnetic resonance apparatus may further comprise auxiliary devices such as a movable table positioning system, a physiological monitoring system, and the like.
Example 3 Process according to the invention
Performing MR examination on the liver cancer patient injected with the gadoxetic acid disodium injection, and scanning by using the following sequence after breath holding: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium injection for 20 minutes (liver and gall specific period), performing breath-holding fat inhibition T1WI three-dimensional gradient echo volume interpolation breath-holding examination sequence, and scanning parameters: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 °; the number of excitations is 1. The scan is completed in about 15 seconds or so.
Example 4 Effect of the method of the invention experiment 1
A liver cancer patient is injected with gadoxetic acid disodium contrast agent (trade name: Pemazao), a high-pressure syringe is used, the injection speed is 2ml/s, the dose is 0.025mmol/kg, 20ml of normal saline is used for flushing, after 20 minutes (liver and gall special period), MR examination is carried out, and the following sequence scanning is used after breath holding: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium injection for 20 minutes (liver and gall specific period), performing breath-holding fat inhibition T1WI three-dimensional gradient echo volume interpolation breath-holding examination sequence, and scanning parameters: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 10 degrees; the number of excitations is 1. The scan is completed in about 15 seconds or so.
The same liver cancer patient is injected with gadoxnate disodium injection, a high-pressure syringe is used, the injection speed is 2ml/s, the dosage is 0.025mmol/kg, 20ml of normal saline is used for flushing, after 20 minutes (liver and gall specific period), MR examination is carried out, and the following sequence scanning is used after breath holding: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium injection for 20 minutes (liver and gall specific period), performing breath-holding fat inhibition T1WI three-dimensional gradient echo volume interpolation breath-holding examination sequence, and scanning parameters: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 °; the number of excitations is 1. The scan is completed in about 15 seconds or so.
The images of the same liver cancer patient from the two MR examinations are shown in FIG. 3. In FIG. 3, A: the turning angle is 10 degrees; b in FIG. 3: the flip angle is 23. Therefore, the low signal image around the tumor is observed by using the image with the flip angle of 10 degrees, the low signal image is difficult to identify by naked eyes, and the low signal image around the tumor is displayed more clearly after the flip angle of 23 degrees and can be identified by naked eyes.
The contrast calculation of the low signal contrast around the tumor from the two MR examinations of the same liver cancer patient is shown in FIG. 4. In FIG. 4, A: the turning angle is 10 degrees; b in fig. 4: the flip angle is 23. Region of interest 1 represents tumor signal intensity, 2 represents low signal shadow signal intensity around the tumor, and 3 represents liver parenchymal signal intensity. In fig. 4, a shows the contrast of the low signal image around the tumor (269.96-255.92)/269.96 (0.052). In fig. 4, B shows the contrast of the low signal image around the tumor (307.76-274.92)/307.76 is 0.107. The contrast increase of low signal image around the tumor after using a flip angle of 23 ° showed 105.77%, calculated by the formula: (0.107-0.052)/0.052 ═ 100% ═ 105.77%.
Example 5 Effect of the method of the invention experiment (II)
1 patient data
After the patients agree and sign an informed consent, 20 liver cancer patients with low signal shadows around liver cancer at the specific stage of liver and gall, who are subjected to gadoxetic acid disodium enhanced magnetic resonance examination in our department, are examined, wherein 15 patients are male, 5 patients are female, and the average age is 55.55 +/-12.62 years old.
2 scanning method
MR imaging was performed 2 times at different flip angles for each patient with liver cancer using a 1.5T whole-body magnetic resonance scanner (magnetic autoreactor, Siemens Medical Solutions, Erlangen, Germany) magnetic resonance imaging system from Siemens Germany. Injection of the disodium gadoxetate contrast agent using a high-pressure syringe at an injection rate of 2ml/s, a dose of 0.025mmol/kg, 20ml flushing with physiological saline, 20 minutes later (liver-gall specific phase), MR examination, after breath-hold scanning using the following sequence: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium injection for 20 minutes (liver and gall specific period), performing breath-holding fat inhibition T1WI three-dimensional gradient echo volume interpolation breath-holding examination sequence, and scanning parameters: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angles are respectively: 10 °, 23 °; the number of excitations is 1.
3 calculating contrast growth rate of low signal shadow
And calculating the contrast of the low signal image around the tumor by using the MR images obtained by different scanning sequences for each liver cancer patient, and simultaneously calculating the increase rate of the contrast of the low signal image around the tumor with the flip angle of 23 degrees compared with the contrast of the low signal image around the tumor with the flip angle of 10 degrees.
4 results
The statistical results of the contrast of the low signal image around the tumor under different scanning sequences are shown in table 1.
TABLE 1 contrast of low signal shadows around tumors under different scan sequences
Clinical test results show that the magnetic resonance scanning method can obviously improve the specificity of low signal shadows around liver cancer for liver cancer patients, is beneficial to quickly obtaining clear images, and reduces the workload of magnetic resonance doctors and technicians.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (7)
1. A method for improving the contrast ratio of low signal contrast around gadoxetic acid disodium liver and gall specific liver cancer is characterized by comprising the following steps: for the liver cancer individual injected with gadoxetate disodium contrast agent, performing magnetic resonance examination, and scanning after breath holding by using the following sequence: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium contrast agent for 20 minutes in the liver and gall specific period, the breath-holding fat inhibits the volume interpolation breath-holding check sequence of T1WI three-dimensional gradient echo, and the scanning parameters are as follows: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 o(ii) a Excitation times are 1; the contrast refers to the contrast between the low signal image around the liver cancer and the liver parenchyma.
2. A magnetic resonance device for improving the contrast of low signal shadow around the gadoxetic acid disodium liver-gall specific-stage liver cancer is characterized in that the magnetic resonance device is provided with a radio frequency generator, and the radio frequency pulse sent by the radio frequency generator makes the flip angleIs always 23 oThe magnetic resonance equipment is used for realizing the following sequence: 1.5T magnetic resonance scanner, after injecting gadoxetic acid disodium contrast agent for 20 minutes in the liver and gall specific period, the breath-holding fat inhibits the volume interpolation breath-holding check sequence of T1WI three-dimensional gradient echo, and the scanning parameters are as follows: TR is 3.5 ms; TE is 1.4 ms; BW 400; matrix: 320 x 180; the flip angle is as follows: 23 o(ii) a Excitation times are 1; the contrast refers to the contrast between the low signal image around the liver cancer and the liver parenchyma.
3. A magnetic resonance apparatus as claimed in claim 2, characterized in that the magnetic resonance apparatus is provided with a main magnet system, a gradient system, a radio frequency system, a system control and a data processing computer.
4. The MR apparatus according to claim 3, wherein the system control and data processing computer comprises a hardware control module, a system adjustment module, an image processing module, and a file management module.
5. The MRI device according to claim 4, wherein the hardware control module is used for controlling hardware operating parameters of the gradient system and the RF system, and has a flip angle control sub-module for controlling RF pulses from the RF generator to make the flip angle always 23 o。
6. The MR apparatus of claim 3, wherein the gradient system comprises gradient coils, gradient amplifiers, digital-to-analog converters, gradient controllers, and gradient cooling devices.
7. The MR apparatus of claim 3, wherein the RF system comprises an RF generator, an RF amplifier, an RF coil, and an RF receiver.
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