CN108324275B - Method and device for acquiring magnetic resonance imaging signal and spectrum signal - Google Patents
Method and device for acquiring magnetic resonance imaging signal and spectrum signal Download PDFInfo
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Abstract
The embodiment of the application discloses a method and a device for acquiring magnetic resonance imaging signals and spectrum signals. The method utilizes an effective time gap between excitation and acquisition of magnetic resonance spectrum signals to acquire magnetic resonance imaging signals before acquiring the magnetic resonance spectrum signals after excitation of a plane of interest of a magnetic resonance scanning object, so that the magnetic resonance imaging signals and the magnetic resonance spectrum signals can be obtained in one magnetic resonance spectrum signal scanning sequence. Therefore, compared with the prior art, the acquisition method provided by the embodiment of the application saves the time for acquiring the magnetic resonance imaging signal, thereby saving the magnetic resonance scanning time and improving the scanning efficiency.
Description
Technical Field
The present application relates to the field of magnetic resonance technology, and in particular, to a method and an apparatus for acquiring magnetic resonance imaging signals and spectrum signals.
Background
Magnetic Resonance Imaging (MRI), which is a multi-parameter, multi-contrast Imaging technique, is one of the main Imaging modes in modern medical Imaging, can reflect various characteristics of tissues T1, T2, proton density and the like, and can provide information for detection and diagnosis of diseases. The basic working principle of magnetic resonance imaging is to excite hydrogen protons in a human body by using a magnetic resonance phenomenon and radio frequency excitation, perform position encoding by using a gradient field, receive electromagnetic signals with position information by using a receiving coil, and finally reconstruct image information by using Fourier transform.
Magnetic Resonance Spectroscopy (MRS) is a method of detection that uses chemical shifts in Magnetic Resonance to determine molecular composition and spatial configuration. MRS is the only method capable of non-invasively detecting chemical substances in living tissues, reflecting tissue cell metabolism and expressing pathological changes at present.
The requirements on the magnetic resonance scanning time in clinical practice are more and more strict, and how to acquire the magnetic resonance imaging signals and the spectroscopic signals in the limited scanning time is crucial to the development of the magnetic resonance clinical diagnosis.
Disclosure of Invention
In view of the above, the embodiments of the present application provide a method and an apparatus for acquiring magnetic resonance imaging signals and spectrum signals, so as to integrate a magnetic resonance imaging signal acquisition process and a magnetic resonance spectrum signal acquisition process into one signal acquisition sequence, thereby achieving the purposes of saving magnetic resonance scanning time and improving scanning efficiency.
In order to achieve the above purpose, the embodiments of the present application adopt the following technical solutions:
a method of acquiring magnetic resonance imaging signals and spectroscopic signals, comprising, in a magnetic resonance signal scanning sequence:
exciting a plane of interest of a magnetic resonance scan subject with an excitation pulse;
acquiring a magnetic resonance imaging signal;
after two 180 ° refocusing pulses perpendicular to the excitation plane, magnetic resonance spectroscopy signals with water signal suppression are acquired.
Optionally, before the acquiring the magnetic resonance imaging signals, the method further includes: an imaging pre-preparation pulse for generating different contrast images is inserted.
Optionally, the inserting of the imaging preparation pulses for generating images with different contrast specifically includes:
before said exciting a plane of interest of the subject with the excitation pulse, an inverted pulse sub-sequence of arterial blood markers upstream of the excitation plane is inserted.
Optionally, the inserting of the imaging preparation pulses for generating images with different contrast specifically includes:
a bipolar pulse gradient for diffusion weighted imaging is interposed between exciting a plane of interest of a subject for magnetic resonance scanning and acquiring magnetic resonance imaging signals.
Optionally, before exciting the plane of interest of the magnetic resonance scanning object with the excitation pulse, further comprising:
a priming pulse for water signal suppression is inserted.
Optionally, after acquiring the magnetic resonance imaging signals and before acquiring the magnetic resonance spectrum signals with water signal suppression, the method further comprises:
a pulse for water signal suppression is inserted after each of the 180 ° refocusing pulses.
An apparatus for acquiring magnetic resonance imaging signals and spectroscopic signals, comprising:
an excitation module for exciting a plane of interest of a magnetic resonance scan subject with an excitation pulse;
the imaging signal acquisition module is used for acquiring a magnetic resonance imaging signal;
and the spectrum signal acquisition module is used for acquiring the magnetic resonance spectrum signal with water signal suppression after two 180-degree back focusing pulses which are vertical to the excitation plane.
Optionally, the apparatus further comprises:
an imaging preparation module for generating imaging preparation pulses of different contrast images prior to acquiring the magnetic resonance imaging signals.
Optionally, the imaging preparation module specifically includes: for performing an inversion pulse sub-sequence of arterial blood labeling upstream of the excitation plane before exciting the plane of interest.
Optionally, the imaging preparation module specifically includes: for performing a bipolar pulse gradient for diffusion weighted imaging between exciting the plane of interest and acquiring the magnetic resonance imaging signals.
Compared with the prior art, the embodiment of the application has the following beneficial effects:
based on the fact that a period of time elapses from signal excitation to signal acquisition in a magnetic resonance spectroscopy signal scan sequence, the acquisition method provided by the embodiment of the present application acquires magnetic resonance imaging signals before the magnetic resonance spectroscopy signals are acquired after excitation of a plane of interest of a subject to be magnetic resonance scanned by using an effective time gap between excitation and acquisition of the magnetic resonance spectroscopy signals, so that the magnetic resonance imaging signals and the magnetic resonance spectroscopy signals can be obtained in one magnetic resonance spectroscopy signal scan sequence, that is, the embodiment of the present application integrates the acquisition process of the magnetic resonance imaging signals into the magnetic resonance spectroscopy signal scan sequence, so that the acquisition method provided by the embodiment of the present application can obtain the magnetic resonance imaging signals and the magnetic resonance spectroscopy signals in one magnetic resonance spectroscopy signal scan sequence, and therefore, the acquisition method provided by the embodiment of the present application integrates the acquisition process of the magnetic resonance imaging signals and the acquisition process of the magnetic resonance spectroscopy signals into one signal acquisition process And (5) collecting sequences. Therefore, compared with the prior art, the acquisition method provided by the embodiment of the application saves the time for acquiring the magnetic resonance imaging signal, thereby saving the magnetic resonance scanning time and improving the scanning efficiency.
Drawings
In order that the detailed description of the present application may be clearly understood, a brief description of the drawings that will be used when describing the detailed description of the present application will be provided. It is to be understood that these drawings are merely illustrative of some of the embodiments of the application.
Figure 1 is a schematic diagram of a magnetic resonance system employed in an embodiment of the present application;
FIG. 2 is a schematic diagram of a gradient echo pulse sequence;
FIG. 3 is a schematic diagram of a magnetic resonance single-element point-resolved spectroscopy spectrum;
FIG. 4 is a schematic diagram of a magnetic resonance signal scanning sequence of a conventional single-element spot resolution method of magnetic resonance spectroscopy;
figure 5 is a schematic diagram of a specific example of a magnetic resonance signal scanning sequence based on single-element point resolution of the magnetic resonance spectrum;
FIG. 6 is a flowchart illustrating an exemplary embodiment of a method for acquiring magnetic resonance imaging signals and spectroscopic signals;
figure 7 is a schematic diagram of another specific example of a magnetic resonance signal scanning sequence based on single-element point resolution of the magnetic resonance spectrum;
figure 8 is a flow chart of another specific example of a method of magnetic resonance imaging signal and spectroscopic signal acquisition provided by an embodiment of the present application;
figure 9 is a schematic diagram of yet another specific example of a magnetic resonance signal scanning sequence based on single-element point resolution of the magnetic resonance spectrum;
figure 10 is a schematic diagram of yet another specific example of a magnetic resonance signal scanning sequence based on single-element point resolution of the magnetic resonance spectrum;
FIG. 11 is a schematic diagram of a control apparatus for performing a method for acquiring magnetic resonance imaging signals and spectroscopic signals in accordance with an embodiment of the present application;
fig. 12 is a schematic structural diagram of an acquisition apparatus for magnetic resonance imaging signals and spectroscopic signals according to an embodiment of the present application.
Detailed Description
At present, the magnetic resonance imaging signal acquisition process and the magnetic resonance spectrum signal acquisition process are two completely independent signal acquisition processes. As such, the magnetic resonance scan time is the sum of the magnetic resonance imaging signal scan time and the spectroscopic signal scan time, resulting in a longer magnetic resonance signal acquisition time and a lower magnetic resonance scan efficiency.
In addition, because the magnetic resonance imaging signal acquisition process and the magnetic resonance spectrum signal acquisition process are completely independent, the time difference exists between the acquisition time of the imaging signal and the acquisition time of the spectrum signal, so that the acquired imaging signal and the spectrum signal are relatively discrete, and if the patient moves in the interval time of the scanning magnetic resonance imaging signal and the scanning magnetic resonance spectrum signal, the acquired magnetic resonance imaging signal and the magnetic resonance spectrum signal may not come from the signal of the same body area of the patient, so that the magnetic resonance imaging and the spectrum cannot be completely registered, thereby bringing trouble to clinical diagnosis.
In the process of solving the technical problems, the inventor of the present application has made the following research findings: in a magnetic resonance spectroscopy signal scanning sequence, the spectroscopy signals are not acquired immediately after signal excitation, but rather a period of time elapses from signal excitation to spectroscopy signal acquisition. The acquisition of the magnetic resonance imaging signals is performed immediately after the excitation, and the excitation pulses during the acquisition of the magnetic resonance imaging signals and the acquisition of the magnetic resonance spectroscopy signals can be shared. Based on the above-mentioned research, it was found that the embodiments of the present application utilize the effective time gap between excitation and acquisition of magnetic resonance spectroscopy signals, after excitation of a plane of interest of a subject for magnetic resonance scanning, magnetic resonance imaging signals are acquired before the acquisition of magnetic resonance spectroscopy signals, and, as such, the magnetic resonance imaging signals and the magnetic resonance spectroscopy signals are available in a magnetic resonance spectroscopy signal scan sequence, i.e., the embodiments of the present application integrate the acquisition of the magnetic resonance imaging signals into the magnetic resonance spectroscopy signal scan sequence, thus, the method for acquiring magnetic resonance imaging signals and spectrum signals provided by the embodiment of the application can obtain the magnetic resonance imaging signals and the magnetic resonance spectrum signals in a magnetic resonance spectrum scanning sequence, therefore, the acquisition method provided by the embodiment of the application integrates the magnetic resonance imaging signal acquisition process and the magnetic resonance spectrum signal acquisition process into one signal acquisition sequence. Therefore, compared with the prior art, the acquisition method provided by the embodiment of the application saves the time for acquiring the magnetic resonance imaging signal, thereby saving the magnetic resonance scanning time and improving the scanning efficiency.
Furthermore, the magnetic resonance imaging signals and the magnetic resonance spectrum signals acquired by the embodiment of the application are signals acquired after one excitation, and the two acquired signals can be ensured to be signals from the same body part of a patient, so that the complete registration of the magnetic resonance imaging and the magnetic resonance spectrum can be ensured, and accurate clinical diagnosis can be ensured.
The following detailed description of specific embodiments of the present application is provided in conjunction with the accompanying drawings.
A magnetic resonance system 10 employed in an embodiment of the present application will first be described with reference to figure 1. Referring to fig. 1, the magnetic resonance system includes a magnetic resonance scanner 11, a console 12, peripheral devices 13, an MRI processing module 14, and an MRS processing module 15.
The internal components of the magnetic resonance scanner 11 include, for example: a superconducting or resistive magnet 111 that generates a static magnetic field (B0), sets of magnetic field gradient coil windings 112 for superimposing selected magnetic field gradients on the static magnetic field, a radio frequency transmit coil 113 for generating a radio frequency field (B1), a radio frequency receive coil 114 for detecting magnetic resonance signals transmitted from the scanned subject, and a patient bed 115 for housing the scanned subject.
The console 12 is used for operator control of the magnetic resonance scan and can display the resulting magnetic resonance imaging and magnetic resonance spectra.
The peripheral device 13 includes a gradient power amplifier 131, a radio frequency power amplifier 132, a receiving unit 133, a gate control unit 134, a radio frequency control unit 135, a gradient control unit 136, a patient bed control unit 137, a sequence control unit 138, and the like.
The MRI processing module 14 is configured to perform image processing, such as fourier transform, on the MRI signal after receiving the MRI signal from the receiving unit 133, so as to generate an MR image.
The MRS processing module 15 is configured to perform image processing, such as fourier transform, on the MRS signal after receiving the MRS signal from the receiving unit 133, and generate an MR spectrum.
The acquisition method of magnetic resonance imaging signals and spectrum signals provided by the embodiment of the present application only relates to the magnetic resonance scanner 11, the console 12, and the peripheral devices 13 in the magnetic resonance system 10 shown in fig. 1, and does not relate to the MRI processing module 14 for image processing and the MRS processing module 15 for spectrum processing.
Embodiments of the present application are described below in terms of gradient echo planar imaging as an example of magnetic resonance imaging and single-voxel point resolution as an example of magnetic resonance spectroscopy acquisition.
Wherein the voxel is a spatial unit in magnetic resonance imaging or spectroscopy acquisition.
Gradient Echo Planar Imaging (EPI) is a fast Imaging sequence widely used at present, and after one-time radio frequency excitation, a series of gradient echoes are generated by using a fast inverse gradient, are respectively phase-coded, are filled into a corresponding k space, and are imaged through fourier transform. Figure 2 shows a schematic diagram of a gradient echo pulse sequence, also called gradient echo pulse sequence timing diagram, showing the time sequence of the application of the various pulses. For example, the line labeled RF represents an RF pulse, which in fig. 2 is a 90 ° pulse. The lines labeled Gx, Gy, and Gz represent gradient pulses applied in the x, y, and z directions, respectively.
The single-element point resolution method is that after once radio frequency excitation, the signal is collected after two echo pulses vertical to an excitation plane, a spectrum signal is limited at the vertical joint of the three pulses (the excitation pulse and the two echo pulses vertical to each other), namely a focus region of interest in the plane, the signal in the region is obtained, and the curve of different chemical substance peaks distributed according to frequency in a rectangular coordinate, namely a magnetic resonance spectrogram, is obtained through Fourier transformation. The corresponding magnetic resonance spectrum is shown in fig. 3.
A magnetic resonance signal scan sequence of a conventional single-element spot resolution method of magnetic resonance spectroscopy is shown in fig. 4. It includes: an excitation pulse 41, a first 180 ° refocusing pulse 42, a second 180 ° refocusing pulse 43 and a magnetic resonance spectrum acquisition sub-sequence 44.
Since about 78% of the water is in vivo, a preparatory pulse for water signal suppression inserted before the magnetic resonance spectrum acquisition sub-sequence 44 may also be included in the sequence shown in fig. 4 in order to suppress the influence of strong water peak signals on the spectrum. Depending on the type of priming pulse 45 used for water signal suppression, the priming pulse for water signal suppression may be inserted before the excitation pulse 41 or after the excitation pulse 41.
The priming pulse for water signal suppression, which is inserted before the excitation pulse 41, can be a wet pumping pulse 45.
The preparatory pulse 45 for water signal suppression inserted after the excitation pulse 41 may be embodied as MEGA (collectively called selective echo-dispersed phase) water pressing pulses 451 and 452 inserted after the first 180 ° refocusing pulse 42 and after the second 180 ° refocusing pulse 43, respectively.
In order to reduce the time of magnetic resonance scanning and improve the scanning speed, the magnetic resonance imaging signal and spectrum signal acquisition process provided by the application is integrated into a magnetic resonance spectrum signal acquisition sequence. In other words, the present embodiments insert a magnetic resonance imaging acquisition sub-sequence into a magnetic resonance spectroscopic signal acquisition sequence. As a specific example of the present application, fig. 5 shows a schematic diagram of a specific example of a magnetic resonance signal scanning sequence based on single-element point resolution of a magnetic resonance spectrum. This magnetic resonance signal scan sequence shown in the specific example includes: a wet-process water-pressurizing pulse 45 for water signal suppression, an excitation pulse 41, a magnetic resonance imaging acquisition sub-sequence 51, a first 180 ° refocusing pulse 42, a second 180 ° refocusing pulse 43, and a magnetic resonance spectrum acquisition sub-sequence 44. As can be seen from the acquisition sequence shown in fig. 5, the present application example inserts a magnetic resonance imaging acquisition sub-sequence 51 between the excitation pulse 41 and the first 180 ° echo pulse 42 in the magnetic resonance spectroscopy acquisition sequence shown in fig. 4.
In this particular example, as shown in figure 6, the method of acquiring magnetic resonance imaging signals and spectroscopic signals in a magnetic resonance signal scan sequence includes the steps of:
s61: a wet water pulse 45 for water signal suppression is applied.
In living organisms, the concentration of metabolites is one ten thousandth of the water concentration, and the effect of water inhibition is to enable small signals from the metabolites to be detected.
In the present example, to suppress the influence of strong water peak signals on the spectrum, a wet water pressure pulse 45 for water signal suppression may be applied before exciting the plane of interest of the magnetic resonance scan object. The wet pressurized water pulses 45 achieve effective suppression of water peaks through the continuous action of a plurality of soft pulses of different flip angles. Typically, the wet pressurized water pulse is added before exciting the plane of interest.
S62: a plane of interest of a magnetic resonance scan subject is excited with an excitation pulse 41.
As an example, a 90 ° RF pulse may be employed as the excitation pulse 41 to excite a plane of interest of the magnetic resonance scan subject.
S63: a magnetic resonance imaging acquisition sub-sequence 51 is performed to acquire magnetic resonance imaging signals.
Immediately after the plane of interest is excited, a magnetic resonance imaging acquisition sub-sequence 51 is performed to acquire magnetic resonance imaging signals.
S64: a first 180 refocusing pulse 42 and a second 180 refocusing pulse 43 are performed perpendicular to the excitation plane.
The 180 refocusing pulse is used to re-phase the protons that are out of phase in the xy plane by 180.
S65: after performing 180 ° echo pulses 42 and 43 perpendicular to the excitation plane, a magnetic resonance spectrum acquisition sub-sequence 44 is performed to acquire magnetic resonance spectrum signals with water signal suppression.
In an embodiment of the present application, the excitation plane is the same plane as a plane of interest of the excited magnetic resonance scan subject.
The above is a specific implementation of an example of the method for acquiring magnetic resonance imaging signals and spectroscopic signals provided by the embodiments of the present application. In this particular implementation, the effective time gap between excitation and acquisition of the magnetic resonance spectrum signals is utilized, and the magnetic resonance imaging signals and the magnetic resonance spectrum signals are acquired before the magnetic resonance spectrum signals are acquired after the excitation of the interest plane of the magnetic resonance scanning object, so that the magnetic resonance imaging signals and the magnetic resonance spectrum signals can be obtained in one magnetic resonance spectrum signal scanning sequence. Therefore, compared with the prior art, the acquisition method provided by the embodiment of the application saves the time for acquiring the magnetic resonance imaging signal, thereby saving the magnetic resonance scanning time and improving the scanning efficiency.
Furthermore, the magnetic resonance imaging signals and the magnetic resonance spectrum signals acquired by the embodiment of the application are signals acquired after one excitation, and the two acquired signals can be ensured to be signals from the same body part of a patient, so that the complete registration of the magnetic resonance imaging and the magnetic resonance spectrum can be ensured, and accurate clinical diagnosis can be ensured.
It should be noted that in the above example, the pre-preparation pulse for water signal suppression is applied before the magnetic resonance imaging signal acquisition, and in fact, the pre-preparation pulse for water signal suppression may be applied after the magnetic resonance imaging signal acquisition according to the scan requirements for generating different contrast images. See in particular the examples below.
Figure 7 shows a schematic diagram of another specific example of a magnetic resonance signal scan sequence based on magnetic resonance spectroscopy single voxel resolution. The magnetic resonance signal scan sequence shown in this particular example includes:
an excitation pulse 41, a magnetic resonance imaging acquisition sub-sequence 71, a first 180 ° refocusing pulse 42, a first MEGA pulse 451 for water signal suppression, a second 180 ° refocusing pulse 43, a second MEGA pulse 452 for water signal suppression, and a magnetic resonance spectroscopy acquisition sub-sequence 44. As can be seen from this sequence, the present example inserts a magnetic resonance imaging acquisition sub-sequence 71 between the excitation pulse 41 and the first 180 ° echo pulse 42 in the magnetic resonance spectroscopy acquisition sequence shown in fig. 4.
In this particular example, as shown in figure 8, the method of acquiring magnetic resonance imaging signals and spectroscopic signals in a magnetic resonance signal scan sequence includes the steps of:
s81: a plane of interest of a magnetic resonance scan subject is excited with an excitation pulse 41.
S82: a magnetic resonance imaging acquisition sub-sequence 71 is performed to acquire magnetic resonance imaging signals.
S83: a first 180 refocusing pulse 42 is performed.
S84: the first MEGA pulse 451 for water signal suppression is applied.
S85: a second 180 refocusing pulse 43 is performed.
S86: a second MEGA pulse 452 for water signal suppression is applied.
S87: a magnetic resonance spectrum acquisition sub-sequence 44 is performed to acquire magnetic resonance spectrum signals with water signal suppression.
It should be noted that, by the above two examples, a magnetic resonance imaging signal capable of reflecting anatomical information and a spectrum signal capable of reflecting tissue metabolic function can be simultaneously acquired in one magnetic resonance scanning sequence.
Furthermore, in order to acquire imaging information other than anatomical structures, for example hemodynamic perfusion weighting information, in one magnetic resonance scan sequence, imaging preparation pulses for generating different contrast images may also be inserted in the sequence shown in the above example. In particular, the imaging pre-preparation pulse may be inserted before the magnetic resonance imaging acquisition sub-sequence.
As an example, fig. 9 shows a scan sequence diagram in which arterial spin label imaging information and spectroscopic information can be acquired in one magnetic resonance scan sequence. As shown in fig. 9, the scanning sequence corresponding to this example may further comprise an inversion pulse subsequence 91 of arterial blood markers inserted before the excitation pulse 41 on the basis of the scanning sequence shown in fig. 7. The method specifically comprises the following steps: an inversion pulse subsequence 91 of arterial blood labeling, an excitation pulse 41, a magnetic resonance imaging acquisition subsequence 71, a first 180 ° refocusing pulse 42, a first MEGA pulse 451 for water signal suppression, a second 180 ° refocusing pulse 43, a first MEGA pulse 452 for water signal suppression, and a magnetic resonance spectrum acquisition subsequence 44.
It is noted that in the present example, the inverted pulse subsequence 91 of the arterial blood marker comprises an inverted pulse of the arterial blood marker and a delay time.
In this example, the water suppression pulse for spectral acquisition must be located after the magnetic resonance imaging sub-sequence 71 in order not to affect the perfusion weighted imaging.
Compared with the acquisition method based on the scan sequence shown in fig. 7, the acquisition method of the magnetic resonance imaging signals and the spectrum signals based on the scan sequence shown in fig. 9 may further include the following steps before step S81:
an inverted pulse sub-sequence 91 of arterial blood labeling is performed.
In this example, by inserting an inverted pulse subsequence 91 of arterial blood markers in the magnetic resonance signal acquisition sequence, hemodynamic perfusion weighting information and physiological metabolic information can be acquired simultaneously in one acquisition sequence. In addition, both the imaging with arterial spin labeling and the spectral acquisition have the property of multiple averaging.
In addition, in this example, the water suppression pulse for the spectral acquisition must be located after the magnetic resonance imaging acquisition sub-sequence in order not to affect the perfusion weighted imaging.
In addition, in order to acquire diffusion weighted imaging, the method may further include, on the basis of the scan sequence shown in fig. 7: a bipolar pulse gradient for diffusion weighted imaging interposed between the excitation pulse and the magnetic resonance imaging acquisition sub-sequence. A corresponding sequence diagram for this example is shown in fig. 10. The method specifically comprises the following steps:
an excitation pulse 41, a bipolar pulse gradient 101, a magnetic resonance imaging acquisition sub-sequence 71, a first 180 ° refocusing pulse 42, a first MEGA pulse 451 for water signal suppression, a second 180 ° refocusing pulse 43, a second MEGA pulse 452 for water signal suppression, and a magnetic resonance spectroscopy acquisition sub-sequence 44.
Based on the scan sequence shown in fig. 10, the method for acquiring magnetic resonance imaging signals and spectroscopic signals provided by the example of the present application may further include the following steps before steps S81 and S82, compared with the method for acquiring magnetic resonance imaging signals and spectroscopic signals based on the scan sequence shown in fig. 7:
a bipolar pulse gradient 101 is performed in preparation for diffusion weighted imaging.
In the above-described embodiment of the method for acquiring a magnetic resonance imaging signal and a spectrum signal according to the embodiments of the present application, a gap before spectrum acquisition in a magnetic resonance spectrum scanning sequence may be fully utilized, a magnetic resonance imaging acquisition sequence is inserted into the gap, the magnetic resonance imaging acquisition sequence may be any fast imaging sequence, and thus, in one sequence, a plurality of contrast information such as magnetic resonance imaging information reflecting anatomical structure information and spectrum information reflecting physiological metabolism may be simultaneously acquired. On the other hand, in order to acquire other magnetic resonance imaging information except for information reflecting anatomical structure, pre-preparation pulses for generating different contrast images may be inserted into the magnetic resonance signal acquisition sequence provided in the embodiment of the present application, and by slightly adjusting elements of the magnetic resonance scanning sequence, other magnetic resonance imaging information except for information reflecting anatomical structure, such as perfusion weighting information or diffusion weighting information of hemodynamics, may be further acquired.
The method for acquiring magnetic resonance imaging signals and spectroscopic signals of the above-described embodiment can be performed by the control device shown in fig. 11. The control device shown in fig. 11 includes a processor (processor1110, communication Interface 1120, memory)1130, and a bus 1140, the processor1110, the communication Interface 1120, and the memory 1130 communicate with each other via the bus 1140.
The memory 1130 may store logic instructions for acquiring magnetic resonance imaging signals and spectroscopy signals, and may be a non-volatile memory (non-volatile memory), for example. The processor1110 may invoke logic instructions to perform the acquisition of magnetic resonance imaging signals and spectroscopy signals in the memory 1130 to perform the magnetic resonance imaging signal and spectroscopy signal acquisition methods described above. As an embodiment, the logic instructions for acquiring the magnetic resonance imaging signals and the spectrum signals may be a program corresponding to control software, and when the processor executes the instructions, the control device may correspondingly display a functional interface corresponding to the instructions on a display interface.
The functions of the logic instructions for acquisition of magnetic resonance imaging signals and spectroscopic signals may be stored in a computer readable storage medium if implemented in the form of software functional units and sold or used as a stand-alone product. Based on such understanding, the technical solutions of the present disclosure may be embodied in the form of a software product, which is stored in a storage medium and includes several instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the methods according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.
The above-mentioned logic instructions for acquiring the magnetic resonance imaging signals and the spectrum signals may be referred to as "acquiring device for the magnetic resonance imaging signals and the spectrum signals", which may be divided into various functional modules. See in particular the examples below.
The following describes a specific implementation of the apparatus for acquiring magnetic resonance imaging signals and spectroscopic signals provided by the embodiments of the present application.
Figure 12 is a schematic diagram of an acquisition device for magnetic resonance imaging signals and spectroscopy signals. As shown in fig. 12, the apparatus includes:
an excitation module 121 for exciting a plane of interest of a magnetic resonance scan subject with excitation pulses;
an imaging signal acquisition module 122 for acquiring magnetic resonance imaging signals;
and a spectrum signal acquisition module 123 for acquiring the magnetic resonance spectrum signal with water signal suppression after two 180 ° refocusing pulses perpendicular to the excitation plane.
In order to acquire imaging information other than anatomical structure in a magnetic resonance scanning sequence, the apparatus may further include:
an imaging preparation module 120 for generating imaging preparation pulses of different contrast images prior to acquiring the magnetic resonance imaging signals.
To enable acquisition of hemodynamic perfusion weighting information, the imaging preparation module 120 may specifically be: for performing an inversion pulse sub-sequence of arterial blood labeling upstream of the excitation plane before exciting the plane of interest.
To enable diffusion weighting of information, the imaging preparation module 120 may specifically be: for performing a bipolar pulse gradient for diffusion weighted imaging between exciting the plane of interest and acquiring the magnetic resonance imaging signals.
The foregoing is a detailed description of the present application.
Claims (10)
1. A method of acquiring magnetic resonance imaging signals and spectroscopic signals, comprising, in a magnetic resonance signal scan sequence:
exciting a plane of interest of a magnetic resonance scan subject with an excitation pulse;
acquiring a magnetic resonance imaging signal;
after two 180 ° refocusing pulses perpendicular to the excitation plane, magnetic resonance spectroscopy signals with water signal suppression are acquired.
2. The method of claim 1, wherein prior to said acquiring magnetic resonance imaging signals, further comprising: an imaging pre-preparation pulse for generating different contrast images is inserted.
3. The method according to claim 2, wherein the inserting of the imaging preparation pulses for generating the different contrast images comprises:
before said exciting a plane of interest of the subject with the excitation pulse, an inverted pulse sub-sequence of arterial blood markers upstream of the excitation plane is inserted.
4. The method according to claim 2, wherein the inserting of the imaging preparation pulses for generating the different contrast images comprises:
a bipolar pulse gradient for diffusion weighted imaging is interposed between exciting a plane of interest of a subject for magnetic resonance scanning and acquiring magnetic resonance imaging signals.
5. The method of claim 1, further comprising, prior to exciting a plane of interest of the magnetic resonance scan subject with the excitation pulse:
a priming pulse for water signal suppression is inserted.
6. The method of any one of claims 1-4, wherein after acquiring the magnetic resonance imaging signals and before acquiring the magnetic resonance spectroscopy signals with water signal suppression, further comprising:
a pulse for water signal suppression is inserted after each of the 180 ° refocusing pulses.
7. An apparatus for acquiring magnetic resonance imaging signals and spectroscopic signals, comprising, implemented in a magnetic resonance signal scanning sequence:
an excitation module for exciting a plane of interest of a magnetic resonance scan subject with an excitation pulse;
the imaging signal acquisition module is used for acquiring a magnetic resonance imaging signal;
and the spectrum signal acquisition module is used for acquiring the magnetic resonance spectrum signal with water signal suppression after two 180-degree back focusing pulses which are vertical to the excitation plane.
8. The apparatus of claim 7, further comprising:
an imaging preparation module for generating imaging preparation pulses of different contrast images prior to acquiring the magnetic resonance imaging signals.
9. The apparatus according to claim 8, wherein the imaging preparation module is specifically: for performing an inversion pulse sub-sequence of arterial blood labeling upstream of the excitation plane before exciting the plane of interest.
10. The apparatus according to claim 8, wherein the imaging preparation module is specifically: for performing a bipolar pulse gradient for diffusion weighted imaging between exciting the plane of interest and acquiring the magnetic resonance imaging signals.
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| US6304084B1 (en) * | 1997-04-14 | 2001-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Method of improved magnetic resonance spectroscopic localization using spectral-spatial pulses |
| DE102006017049B3 (en) * | 2006-04-11 | 2008-02-14 | Siemens Ag | Method of recording magnetic resonance image data and magnetic resonance device |
| EP2320245A1 (en) * | 2009-11-05 | 2011-05-11 | Koninklijke Philips Electronics N.V. | MR imaging using navigators |
| WO2012110927A1 (en) * | 2011-02-15 | 2012-08-23 | Koninklijke Philips Electronics N.V. | Magnetic resonance spectroscopy with automatic phase and b0 correction using interleaved water reference scan |
| DE112013004852T5 (en) * | 2012-10-02 | 2015-06-18 | Philips Gmbh | Metal-insensitive MR imaging reference scan |
| US9775557B2 (en) * | 2013-04-03 | 2017-10-03 | Vanderbilt University | Quantifying breast tissue changes with spectrally selective MRI and MRS |
| CN106249183B (en) * | 2016-09-24 | 2018-10-12 | 中国科学院武汉物理与数学研究所 | One kind is based on spectrum as integrated hyperpolarization xenon magnetic resonance method |
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