CN109141570B - Temperature control type flexible capacitance sensor for drug release and preparation method - Google Patents
Temperature control type flexible capacitance sensor for drug release and preparation method Download PDFInfo
- Publication number
- CN109141570B CN109141570B CN201811092026.8A CN201811092026A CN109141570B CN 109141570 B CN109141570 B CN 109141570B CN 201811092026 A CN201811092026 A CN 201811092026A CN 109141570 B CN109141570 B CN 109141570B
- Authority
- CN
- China
- Prior art keywords
- temperature
- drug release
- polar plate
- silk fibroin
- controlled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 51
- 229940079593 drug Drugs 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000010408 film Substances 0.000 claims abstract description 68
- 108010022355 Fibroins Proteins 0.000 claims abstract description 42
- 239000000017 hydrogel Substances 0.000 claims abstract description 40
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229910021389 graphene Inorganic materials 0.000 claims abstract description 33
- 239000000758 substrate Substances 0.000 claims abstract description 24
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000013267 controlled drug release Methods 0.000 claims abstract description 15
- 239000010409 thin film Substances 0.000 claims abstract description 10
- 238000005516 engineering process Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000000599 controlled substance Substances 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 5
- 238000005553 drilling Methods 0.000 claims description 5
- 238000000059 patterning Methods 0.000 claims description 5
- 238000005266 casting Methods 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000001020 plasma etching Methods 0.000 claims description 3
- 238000005530 etching Methods 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 238000010030 laminating Methods 0.000 claims 1
- 230000008859 change Effects 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 239000003990 capacitor Substances 0.000 abstract 1
- 238000005229 chemical vapour deposition Methods 0.000 description 7
- 238000011160 research Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- -1 polyethylene terephthalate Polymers 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 2
- 229920003207 poly(ethylene-2,6-naphthalate) Polymers 0.000 description 2
- 239000011112 polyethylene naphthalate Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- FIHBHSQYSYVZQE-UHFFFAOYSA-N 6-prop-2-enoyloxyhexyl prop-2-enoate Chemical compound C=CC(=O)OCCCCCCOC(=O)C=C FIHBHSQYSYVZQE-UHFFFAOYSA-N 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000011982 device technology Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000009450 smart packaging Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
Landscapes
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Preparation (AREA)
Abstract
A temperature-controlled flexible capacitive sensor for drug release and a preparation method thereof, wherein the capacitive sensor comprises a first polar plate, a second polar plate and a temperature-controlled drug release hydrogel film positioned between the first polar plate and the second polar plate; the first polar plate and the second polar plate comprise: the silk fibroin electrode structure comprises a flexible substrate, a silk fibroin thin film layer on the flexible substrate and a graphene electrode layer on the silk fibroin thin film layer; the temperature control type drug release hydrogel film is a poly N-isopropyl acrylamide temperature sensitive film. The invention provides a temperature-control flexible capacitance sensor for drug release, which is characterized in that when the environmental temperature changes, the retractility of a temperature-control drug release hydrogel film is utilized to adjust the drug release, and further, the distance between two electrode plates of a capacitor changes, which is reflected as the change of capacitance.
Description
Technical Field
The invention relates to the technical field of temperature-controlled drug release, in particular to a temperature-controlled flexible capacitive sensor for drug release and a preparation method thereof.
Background
In a quantitative administration system, the most ideal administration mode is fixed-point, timed and quantitative release of the medicament, thereby maintaining normal blood concentration, not causing medicament accumulation poisoning and simultaneously reducing the toxic and side effects of the medicament. Biosensors and microfluidic systems based on the MEMS technology have received much attention, provide powerful tools for research and exploration of life sciences, and are now widely used in the fields of biomedical engineering and the like. At present, most sensors for drug release are integrated on a single chip by adopting an MEMS (micro electro mechanical systems) technology, but the MEMS integrated device technology is complex, high in cost and serious in environmental pollution. Research and development on solubilized organic and inorganic materials, particularly hydrogels, have prompted application research on various flexible smart devices over the last 10 years. The device made of the organic and inorganic materials in solution is different from silicon-based microelectronics, and is mainly characterized in that the device is deposited on any material in an additive manufacturing mode to prepare a flexible device with large area, flexibility and low cost. The flexible sensor has flexible and various structural forms, can be randomly arranged according to the requirements of measuring conditions, can very conveniently carry out accurate and rapid measurement on special environments and signals, and has important functions in the fields of biological medicines, electronic skins, wearable electronic products and intelligent packaging. The temperature-controlled drug release hydrogel film is used as a sensitive film of the sensor, the drug release amount is restricted by temperature, and the release shows a 'fast/slow' response characteristic along with temperature oscillation. When the temperature is lower than 32 ℃, the poly-N-isopropyl acrylamide hydrogel film is in a swelling state, and the diffusion rate of the drug molecules dissolved in the solvent is very low. When the temperature is higher than 32 ℃, the poly N-isopropyl acrylamide hydrogel film suddenly shrinks, and the water and the medicine in the hydrogel are released outwards. The principle that the temperature-sensitive hydrogel film expands and contracts along with the temperature to cause volume change is utilized to manufacture the variable-pitch capacitive sensor, and the variable-pitch capacitive sensor becomes a research hotspot in the world. Is also an important way and a research hotspot for realizing the effective control and release of the drug in the field of biomedical microelectronic research.
Disclosure of Invention
The invention aims to solve part of problems existing in the existing biosensor and microfluidic drug release system based on the MEMS technology, and provides a temperature control type flexible capacitance sensor for drug release and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a temperature-controlled flexible capacitive sensor for drug release comprises a first polar plate, a second polar plate and a temperature-controlled drug release hydrogel film positioned between the first polar plate and the second polar plate; the first polar plate and the second polar plate comprise: the silk fibroin electrode structure comprises a flexible substrate, a silk fibroin thin film layer on the flexible substrate and a graphene electrode layer on the silk fibroin thin film layer; the temperature control type drug release hydrogel film is a poly N-isopropyl acrylamide temperature sensitive film.
Preferably, the material of the flexible substrate is one of PET (polyethylene terephthalate), PI (polyimide), PVA (polyvinyl alcohol) and PEN (polyethylene naphthalate); the silk fibroin film layer on the surface of the flexible substrate is used as an insulating layer.
Preferably, the surface of the flexible substrate is coated with a silk fibroin film layer with the thickness of 30nm-100nm, then the silk fibroin film layer is immersed into a silk fibroin solution with the concentration of 3% -8% (by mass), and the silk fibroin film layer is taken out and dried at 70-200 ℃ to obtain the silk fibroin film layer on the surface of the flexible substrate.
Preferably, the thickness of the silk fibroin thin film layer on the flexible substrate is 200nm-600nm, and the thickness of the graphene electrode layer is 50nm-150 nm.
Preferably, the graphene electrode layer is formed by transferring CVD graphene to the surface of the silk fibroin thin film layer, and then patterning the CVD graphene layer by using reactive ion etching.
Preferably, the first plate has pores of 10 μm to 100 μm.
Preferably, the temperature-controlled drug release hydrogel film is a poly N-isopropylacrylamide temperature-sensitive film with the thickness of 5-200 mu m.
Preferably, when the temperature of the poly-N-isopropylacrylamide temperature-sensitive film is lower than 32 ℃, the poly-N-isopropylacrylamide hydrogel film is in a swelling state, and the drug molecules still stay in the solvent with small diffusion rate. When the temperature is higher than 32 ℃, the poly N-isopropyl acrylamide hydrogel film is severely shrunk, and the water and the medicine in the hydrogel are released outwards.
Preferably, the temperature-controlled drug release hydrogel film is formed on the surface of the graphene electrode layer of the second electrode plate.
Preferably, the side surface of the laminated structure formed by the first polar plate, the temperature control type drug release hydrogel film and the second polar plate is encapsulated by PDMS.
Another aspect of the present invention is a method for preparing a temperature-controlled flexible capacitive sensor for drug release, comprising the steps of:
(1) preparing a first polar plate and a second polar plate: preparing a silk fibroin film layer on the surface of a flexible substrate to serve as an insulating layer, transferring CVD (chemical vapor deposition) graphene to the surface of the silk fibroin film layer, and then etching the graphene by utilizing reactive ions to perform patterning to obtain a graphene electrode layer; drilling a small hole of 10-100 μm for drug release on the first polar plate by using a laser drilling technology;
(2) coating a poly N-isopropyl acrylamide casting solution on the surface of the graphene electrode layer of the second polar plate by adopting a coating method to form a temperature-controlled drug release hydrogel film;
(3) and the first polar plate is laminated on the temperature control type drug release hydrogel film.
The silk fibroin film layer on the flexible substrate in the step (1) is 200nm-600nm thick; the thickness of the graphene electrode layer is 50nm-250 nm.
Preferably, the thickness of the temperature-controlled drug release hydrogel film of the step (2) is 5 μm to 200 μm.
Preferably, PDMS (polydimethylsiloxane) is used to encapsulate the side of the laminated structure formed by the first plate, the temperature-controlled drug release hydrogel film and the second plate.
The invention has the beneficial effects that: the invention provides a temperature control type flexible capacitance sensor for drug release and a preparation method thereof, which can expand a drug release system and an in-vitro drug release behavior construction scheme. The silk fibroin which is a natural polymer material has the advantages of excellent mechanical property, excellent light transmission, degradability, good biocompatibility and the like, and conforms to the national sustainable development strategy. Meanwhile, the application of graphene and silk fibroin in the biological field and the sensing field is combined, and the method has important practical significance for developing a novel pollution-free, fixed-point, timing and quantitative drug delivery system. The temperature control type flexible capacitance sensor for drug release has the advantages of simple principle, good flexibility, good biological safety, low cost, abundant reserves of materials for preparation and environmental friendliness, and is realized by adopting simple instruments and conventional process flows, thereby being beneficial to popularization and application.
Drawings
Fig. 1 is a schematic structural diagram of a temperature-controlled flexible capacitive sensor for drug release obtained in example 1.
Wherein, 1 is a flexible substrate; 2 is a silk fibroin film layer; 3 is a graphene electrode layer; 4 is a temperature-controlled drug-release hydrogel film.
Detailed Description
In order to better explain the invention, the technical solutions in the embodiments of the invention are further described in detail below with reference to the drawings in the embodiments of the invention.
Example 1
The structure of the temperature-controlled flexible capacitive sensor for drug release obtained in this embodiment is shown in fig. 1, and includes a first plate (for example, above the temperature-controlled drug-releasing hydrogel film 4 in the figure), a second plate (for example, below the temperature-controlled drug-releasing hydrogel film 4 in the figure), and a temperature-controlled drug-releasing hydrogel film 4 located therebetween; the first plate and the second plate may have the same layer structure, and specifically may include: the silk fibroin electrode structure comprises a flexible substrate 1, a silk fibroin thin film layer 2 and a graphene electrode layer 3;
wherein the silk fibroin film layer 2 is positioned on the flexible substrate 1; the surface of a flexible substrate 1 is coated with a 50 nm-thick silk fibroin film layer in a spinning mode, then the silk fibroin film layer is immersed into a silk fibroin solution with the concentration of 5% (mass), the silk fibroin film layer is taken out and dried at 75 ℃, and then a silk fibroin film layer 2 with the thickness of 450nm can be prepared on the surface of the flexible substrate 1, and the silk fibroin film layer 2 serves as an insulating layer;
preparing graphene by adopting a CVD (chemical vapor deposition) method, transferring the graphene prepared by the CVD method to the surface of the silk fibroin film layer 2 by adopting a heat release adhesive tape, and patterning the graphene on the surface of the silk fibroin film layer 2 by adopting a reactive ion etching technology to obtain a graphene electrode layer 3 so as to obtain a polar plate, wherein a laser drilling technology is adopted to drill a small hole of 10-100 mu m on a first polar plate for drug release;
reacting N-isopropyl acrylamide monomer, alkali-treated PVDF powder and azobisisobutyronitrile to prepare the PVDF-g-PNIPAAm truncated copolymer, and reacting at 80 ℃ for 1 hour. 15g of PVDF-g-PNIPAAm truncated copolymer is dissolved in 32ml of DMF solvent for reaction at 60 ℃ for 3 hours, and the poly N-isopropylacrylamide casting solution is prepared after full stirring and defoaming. Meanwhile, 0.5g of 1, 6-hexanediol diacrylate is added for carrying out thermal crosslinking on the residual azodiisobutyronitrile in the drying process, so that the strength of the membrane is improved, and the phenomenon that the temperature-controlled drug release hydrogel membrane is not tightly combined with the graphene silk fibroin membrane electrode layer in the repeated swelling process is avoided.
And then coating the surface of the graphene electrode layer 3 of the dry and clean second electrode plate with a film with the thickness of about 80 mu m, and immediately putting the film into purified water with the temperature of 25 ℃ for solidification and molding to obtain the temperature-controlled drug release hydrogel film 4.
The side surface (vertical to each surface of the first polar plate and the second polar plate) of the laminated structure formed by the first polar plate with the micropore structure, the temperature control type drug release hydrogel film and the second polar plate is encapsulated by PDMS.
The silk fibroin film layer 2 on the flexible substrate 1 is 200nm-600nm thick, and the graphene electrode layer 3 is 50nm-150nm thick.
When the temperature of the poly N-isopropyl acrylamide temperature-sensitive film is lower than 32 ℃, the poly N-isopropyl acrylamide hydrogel film is in a swelling state, and the drug molecules still stay in the solvent with small diffusion rate. When the temperature is higher than 32 ℃, the poly N-isopropyl acrylamide hydrogel film suddenly shrinks, and the water and the medicine in the hydrogel are released outwards.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention disclosed herein should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A temperature-control flexible capacitive sensor for drug release is characterized by comprising a first polar plate, a second polar plate and a temperature-control drug release hydrogel film positioned between the first polar plate and the second polar plate; the first polar plate and the second polar plate comprise: the silk fibroin electrode structure comprises a flexible substrate, a silk fibroin thin film layer on the flexible substrate and a graphene electrode layer on the silk fibroin thin film layer; the temperature control type drug release hydrogel film is a poly N-isopropyl acrylamide temperature sensitive film.
2. The temperature-controlled flexible capacitive sensor for drug release according to claim 1, wherein the flexible substrate is made of one of PET, PI, PVA and PEN; the silk fibroin film layer on the surface of the flexible substrate is used as an insulating layer.
3. The temperature-controlled flexible capacitive sensor for drug release according to claim 1, wherein the graphene electrode layer is formed by transferring CVD graphene to the surface of a silk fibroin thin film layer, and then patterning the CVD graphene by using reactive ion etching; the first polar plate is provided with small holes with the diameter of 10-100 mu m.
4. The temperature-controlled flexible capacitive sensor for drug release according to claim 1, wherein the silk fibroin film layer on the flexible substrate has a thickness of 200nm-600nm, and the graphene electrode layer has a thickness of 50nm-150 nm.
5. The temperature-controlled flexible capacitive sensor for drug release of claim 1, wherein the thickness of the temperature-controlled drug-releasing hydrogel film is 5 μm to 200 μm.
6. The temperature-controlled flexible capacitive sensor for drug release according to claim 1, wherein the poly-N-isopropylacrylamide temperature-sensitive film is a drug carrier, and when the temperature is increased, the poly-N-isopropylacrylamide gel network shrinks to release the drug.
7. The temperature-controlled flexible capacitive sensor for drug release of claim 1, wherein the temperature-controlled drug-releasing hydrogel film is formed on the surface of the graphene electrode layer of the second plate.
8. The temperature-controlled flexible capacitive sensor for drug release according to claim 1, wherein the side of the laminated structure formed by the first plate, the temperature-controlled drug-releasing hydrogel film and the second plate is encapsulated with PDMS.
9. The method for preparing a temperature-controlled flexible capacitive sensor for drug release according to any one of claims 1 to 8, comprising the steps of:
(1) preparing a first polar plate and a second polar plate: preparing a silk fibroin film layer on the surface of a flexible substrate to serve as an insulating layer, transferring CVD graphene to the surface of the silk fibroin film layer, and then etching the graphene by utilizing reactive ions to perform patterning to obtain a graphene electrode layer; drilling a small hole of 10-100 μm for drug release on the first polar plate by using a laser drilling technology;
(2) coating a poly N-isopropyl acrylamide casting solution on the surface of the graphene electrode layer of the second polar plate by adopting a coating method to form a temperature-controlled drug release hydrogel film;
(3) laminating a first polar plate on the temperature-controlled drug release hydrogel film;
the silk fibroin film layer on the flexible substrate in the step (1) is 200nm-600nm thick, the graphene electrode layer is 50nm-150nm thick, and the temperature control type drug release hydrogel film in the step (2) is 5 μm-200 μm thick.
10. The method of claim 9, wherein the side of the stacked structure of the first plate, the temperature-controlled drug release hydrogel film and the second plate is encapsulated with PDMS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811092026.8A CN109141570B (en) | 2018-09-18 | 2018-09-18 | Temperature control type flexible capacitance sensor for drug release and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811092026.8A CN109141570B (en) | 2018-09-18 | 2018-09-18 | Temperature control type flexible capacitance sensor for drug release and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109141570A CN109141570A (en) | 2019-01-04 |
| CN109141570B true CN109141570B (en) | 2020-04-07 |
Family
ID=64814953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811092026.8A Active CN109141570B (en) | 2018-09-18 | 2018-09-18 | Temperature control type flexible capacitance sensor for drug release and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109141570B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112442204B (en) * | 2020-11-13 | 2023-01-03 | 浙江理工大学 | Preparation method of flexible temperature sensor |
| CN113406154B (en) * | 2021-06-17 | 2022-02-18 | 哈尔滨工业大学 | Three-dimensional hydrogel-graphene-based biosensor and preparation method thereof |
| CN114873929B (en) * | 2022-05-18 | 2023-04-14 | 北京印刷学院 | Novel sensor material and preparation method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10799593B2 (en) * | 2008-06-09 | 2020-10-13 | Northwestern University | Nanodiamond particle complexes |
| WO2015089491A1 (en) * | 2013-12-14 | 2015-06-18 | The Regents Of The University Of California | Liquid column-based capacitive sensors |
| JP6544744B2 (en) * | 2015-01-27 | 2019-07-17 | 国立研究開発法人物質・材料研究機構 | Sensor with porous or particulate material as receptor layer |
| CN106017718B (en) * | 2016-07-28 | 2018-04-06 | 国网山西省电力公司忻州供电公司 | Flexibility temperature sensor |
| CN106648272B (en) * | 2016-12-28 | 2020-02-14 | 无锡第六元素电子薄膜科技有限公司 | Ultrathin flexible capacitive touch sensor based on graphene and preparation method thereof |
| CN107610941A (en) * | 2017-08-02 | 2018-01-19 | 苏州柔能纳米科技有限公司 | The preparation technology of flexible super capacitor agent structure |
| CN107958794A (en) * | 2017-10-27 | 2018-04-24 | 东华大学 | All solid state graphene hydrogel ultracapacitor of ultrathin flexible and preparation method thereof |
-
2018
- 2018-09-18 CN CN201811092026.8A patent/CN109141570B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN109141570A (en) | 2019-01-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109141570B (en) | Temperature control type flexible capacitance sensor for drug release and preparation method | |
| CN109115376A (en) | A kind of condenser type pliable pressure sensor and preparation method thereof | |
| Zhang et al. | Flexible highly sensitive pressure sensor based on ionic liquid gel film | |
| Gao et al. | All paper-based flexible and wearable piezoresistive pressure sensor | |
| CN112834086B (en) | Ultra-sensitive capacitive flexible pressure sensor and preparation method thereof | |
| Zhao et al. | Simultaneous high sensitivity sensing of temperature and humidity with graphene woven fabrics | |
| Ha et al. | Bioinspired interlocked and hierarchical design of ZnO nanowire arrays for static and dynamic pressure‐sensitive electronic skins | |
| Ma et al. | Recent progress in flexible capacitive sensors: Structures and properties | |
| CN110398259B (en) | Flexible sensing device with multiple sensing functions and preparation method thereof | |
| Kang et al. | Hydrogel-templated transfer-printing of conductive nanonetworks for wearable sensors on topographic flexible substrates | |
| CN208765878U (en) | A kind of condenser type pliable pressure sensor | |
| Wan et al. | Asymmetric Janus adhesive tape prepared by interfacial hydrosilylation for wet/dry amphibious adhesion | |
| CN111562038A (en) | Flexible capacitive pressure sensor and flexible capacitive pressure array sensor | |
| Lei et al. | Bioinspired quasi-solid ionic conductors: materials, processing, and applications | |
| CN110231056B (en) | Method for preparing microstructure electrode by utilizing ink-jet printing flexible microstructure surface and electronic skin sensor | |
| Yi et al. | A new approach for an ultra-thin piezoresistive sensor based on solidified carbon ink film | |
| Liu et al. | Ultrasensitive iontronic pressure sensor based on rose-structured ionogel dielectric layer and compressively porous electrodes | |
| Wang et al. | Mechanical gradients enable highly stretchable electronics based on nanofiber substrates | |
| CN113816362B (en) | Preparation method of precision patterned three-dimensional porous graphene, and precision transfer printing method and application thereof | |
| CN106953001A (en) | A kind of pliable pressure sensor based on carbon nano-tube film and photoresist and preparation method thereof | |
| CN110526198A (en) | A kind of pliable pressure sensor and its manufacturing method based on hemispherical micro-structure | |
| CN109029801B (en) | Metal nanowire composite film pressure sensor and preparation method thereof | |
| CN113029399B (en) | Pressure sensor based on conductive polymer fold coating and application thereof | |
| Mo et al. | A Review of Conductive Hydrogel‐Based Wearable Temperature Sensors | |
| Wu et al. | Double layered asymmetrical hydrogels enhanced by thermosensitive microgels for high-performance mechanosensors and actuators |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231211 Address after: 311217 Building C, Shengzhong Village, Xinjie Street, Xiaoshan District, Hangzhou City, Zhejiang Province, China, 1003-1005 Patentee after: Hangzhou Zhiwei Medical Equipment Co.,Ltd. Address before: 100083 No.1 Xinghua Street (Section 2), Daxing District, Beijing Patentee before: BEIJING INSTITUTE OF GRAPHIC COMMUNICATION Patentee before: GUANGDONG XINKE MEDICAL TECHNOLOGY Co.,Ltd. |