CN109140909B - Freeze dryer plate layer temperature control method and system - Google Patents
Freeze dryer plate layer temperature control method and system Download PDFInfo
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- CN109140909B CN109140909B CN201810935701.2A CN201810935701A CN109140909B CN 109140909 B CN109140909 B CN 109140909B CN 201810935701 A CN201810935701 A CN 201810935701A CN 109140909 B CN109140909 B CN 109140909B
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- 238000000034 method Methods 0.000 title claims abstract description 62
- 238000005057 refrigeration Methods 0.000 claims abstract description 55
- 238000001514 detection method Methods 0.000 claims abstract description 46
- 238000000859 sublimation Methods 0.000 claims abstract description 40
- 230000008022 sublimation Effects 0.000 claims abstract description 40
- 238000007710 freezing Methods 0.000 claims abstract description 35
- 230000008014 freezing Effects 0.000 claims abstract description 35
- 230000008569 process Effects 0.000 claims description 40
- 238000001816 cooling Methods 0.000 claims description 12
- 239000003814 drug Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 230000008859 change Effects 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 230000009467 reduction Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000000630 rising effect Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B41/00—Fluid-circulation arrangements
- F25B41/40—Fluid line arrangements
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B49/00—Arrangement or mounting of control or safety devices
- F25B49/02—Arrangement or mounting of control or safety devices for compression type machines, plants or systems
- F25B49/022—Compressor control arrangements
Abstract
The invention discloses a freeze dryer plate layer temperature control method and a system, wherein in a pre-freezing mode, a refrigeration compressor is controlled to work to cool a plate layer, in a sublimation mode, a heater is controlled to work to heat the plate layer, in the pre-freezing mode and the sublimation mode, the sum of the plate layer outlet detection temperature T2 and the system temperature rise delta T is compared with the value of a set reference temperature value, whether the refrigeration compressor needs to work or not and whether the heater needs to work or not are judged, so that the detection temperature T1 at the plate layer inlet is infinitely close to the set reference temperature value, a freeze dryer plate layer temperature control system comprises a plate layer heat exchange loop communicated with the freeze dryer plate layer, a circulating pump, the heater and a heat exchanger which are sequentially connected in series are arranged on the plate layer heat exchange loop, the heat exchanger is connected with the refrigeration compressor, a first temperature detection piece is positioned at the inlet of the freeze dryer plate layer, a, simple and efficient, stable and reliable, and high control precision.
Description
Technical Field
The invention relates to the field of food and medicine production, in particular to a freeze dryer plate layer temperature control method and system.
Background
The physical essence of the freeze-drying process is the heat and mass transfer process under low temperature and low pressure, the temperature control is a crucial link, and the precision of the temperature control directly influences the quality of products. The temperature control system of the freeze dryer generally comprises a compressor, a heat exchanger, a heater, a circulating pump and a heat exchange medium (silicone oil). The heat exchange is carried out by adopting a silicone oil medium, so that the heat exchanger has obvious hysteresis. The prior art temperature control process is as follows: when the temperature detection value of the inlet of the plate layer is larger than a set value, the compressor system is started, and the refrigerant is conveyed to the heat exchanger to exchange cold with a heat exchange medium (silicon oil) so as to realize cooling. When the temperature detection value of the inlet of the plate layer is smaller than the set value, the electric heater is started to realize temperature rise. The inlet temperature of the plate layer is a main control object, and the electric heater and the liquid supply valve of the compressor are controlled by a PID algorithm. According to the traditional PID control method, two paths of independent control are adopted to realize control on the same target, but the temperature change in the freeze-dried plate layer is uncontrollable and has hysteresis, the stability of the temperature detection value of the inlet of the plate layer is still maintained after heat exchange is realized in the freeze-dried plate layer, and the system is easy to vibrate, namely, the temperature rise of a heater and the temperature reduction of a compressor are continuously and alternately carried out all the time, so that the temperature control precision of the system is poor, and even the components and the appearance of medicines are damaged; in addition, the compressor is frequently switched to the plate layer from the cold trap cooling and controls the temperature, and the refrigeration capacity of the cold trap of the freeze dryer is easy to lose, so that the whole freeze-drying process is influenced.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a method and a system for controlling the temperature of a freeze dryer plate layer, which are simple, efficient, stable, reliable and high in control precision.
In order to solve the technical problems, the invention adopts the following technical scheme:
the utility model provides a freeze dryer sheet layer temperature control method, in the prefreezing mode, control refrigeration compressor work makes the sheet layer cool down, in the sublimation mode, control heater work makes the sheet layer heat up, in prefreezing mode and sublimation mode, all through the numerical value size of comparing sheet layer export detection temperature T2 and system temperature rise delta T sum and setting for reference temperature value, judge whether refrigeration compressor needs work and whether the heater needs work to adjust sheet layer entry detection temperature T1 is infinitely close set for reference temperature value.
As a further improvement of the above technical solution:
setting a pre-freezing reference temperature value as T0, wherein the pre-freezing mode comprises the following steps:
s101, when T1 is greater than T0, the process goes to step S102;
s102, if T2> T0, the process goes to step S104, and if T2< T0, the process goes to step S103;
s103, if T2 +. DELTA.T > T0, the process proceeds to step S104, and if T2 +. DELTA.T < T0, the heater is controlled to work to heat the slab layer;
and S104, controlling the refrigeration compressor to work to cool the slab layer.
Setting a sublimation reference temperature value as T0', wherein the sublimation mode comprises the following steps:
s201, when T1 is less than T0', the flow proceeds to step S202;
s202, if T2> T0 ', the process goes to step S204, and if T2< T0', the process goes to step S203;
s203, if T2 +. DELTA.T > T0 ', the process proceeds to step S204, and if T2 +. DELTA.T < T0', the heater is controlled to work to heat the slab layer;
and S204, controlling the refrigeration compressor to work to cool the slab layer.
Before the steps S101 and S201, the following steps are further included:
s301, starting a circulating pump;
s302, if the detected circulating pressure difference is not in the set range, sending an alarm signal, and if the detected circulating pressure difference is in the set range, entering the step S303;
s303, turning on a heater power supply and a refrigeration compressor;
and S304, judging to enter a pre-freezing mode or a sublimation mode.
Before the steps S101 and S201, a system temperature rise Δ T, which is a temperature rise value when the heat exchange medium circulates from the slab outlet to the slab inlet through the circulation pump, is obtained through actual detection.
When the refrigeration compressor works, the opening degree of an electronic expansion valve of the refrigeration compressor is adjusted by a PID control method, and when the heater works, the output power of the electric heater is adjusted by the PID control method.
And when the refrigeration compressor does not work, the refrigeration compressor is automatically switched to a cold trap cooling state.
The utility model provides a freeze dryer sheet layer temperature control system, include with the sheet layer heat transfer circuit of freeze dryer sheet layer intercommunication, be equipped with circulating pump, heater and the heat exchanger of establishing ties in proper order on the sheet layer heat transfer circuit, the heat exchanger is connected with compressor, still be equipped with first temperature detection spare and second temperature detection spare on the sheet layer heat transfer circuit, first temperature detection spare is located the entrance of freeze dryer sheet layer, the second temperature detection spare is located the exit of freeze dryer sheet layer.
As a further improvement of the above technical solution:
the pipeline that the refrigeration compressor communicates with the heat exchanger is provided with a first refrigeration liquid supply valve and a first electronic expansion valve which are connected in series, the PID controller of the refrigeration compressor is communicated with the electronic expansion valve, and the heater comprises a PID controller.
The freeze dryer plate layer temperature control system further comprises a cold trap device, wherein the cold trap device is communicated with the refrigeration compressor and is provided with a second refrigeration liquid supply valve and a second electronic expansion valve on a communicating pipeline.
Compared with the prior art, the invention has the advantages that:
(1) in the pre-freezing mode, a medicine is converted from a liquid state to a solid state, which is a heat release process, the plate layer needs to take away heat released by the medicine, after heat exchange, the plate layer outlet detection temperature is certainly higher than the plate layer inlet detection temperature T1, and in the working process, the system temperature rise delta T generated by a system circulating from the plate layer outlet position to the plate layer inlet position is a fixed value and cannot be changed in a vibration mode, so that the temperature rise delta T required by the system can be judged in advance to be increased or reduced to achieve that the plate layer inlet detection temperature T1 is infinitely close to the set pre-freezing reference temperature value by comparing the sum of the plate layer outlet detection temperature T2 and the system temperature rise delta T with the set pre-freezing reference temperature value, namely, the temperature control requirement of the pre-freezing mode can be met only through a single process of temperature increase or temperature reduction, and the temperature increase or temperature increase required by detecting the plate layer inlet detection temperature T1 is judged by comparing the heat medium circulating to the The temperature is reduced, the alternating operation of temperature rise and temperature reduction caused by frequent oscillation due to the hysteresis of the system can be avoided, the stability of the system is influenced, the control process is simple, efficient, stable and reliable, and the control precision is high; in the same way, in the sublimation mode, the medicine is from solid-state direct transformation gaseous state, this is an endothermic process, the board layer needs the sublimation of medicine to provide the heat, after the heat transfer, the board layer export detected temperature must be than board layer entry detected temperature T1 low, therefore, through comparing board layer export detected temperature T2 and system temperature rise DeltaT sum and the numerical value size of setting for sublimation reference temperature value, just can judge in advance that the system needs to heat up or lower the temperature and realize that board layer entry detected temperature T1 is unlimited to be close to and set for sublimation reference temperature value, just need the single process of rising temperature or cooling just can satisfy the temperature control demand of sublimation mode, control process is simple high-efficient, and stable and reliable, and high in control accuracy.
(2) According to the freeze dryer plate layer temperature control system, the plate layer inlet detection temperature T1 is obtained through the first temperature detection piece, the plate layer outlet detection temperature T2 is obtained through the second temperature detection piece, and therefore whether the refrigeration compressor needs to work or not and whether the heater needs to work or not can be judged by comparing the sum of the plate layer outlet detection temperature T2 and the system temperature rise delta T with the set reference temperature value, and the plate layer inlet detection temperature T1 is adjusted to be infinitely close to the set reference temperature value.
Drawings
Fig. 1 is a flow chart of a method of temperature control of a freeze dryer sheet layer of the present invention.
Fig. 2 is a schematic structural diagram of a freeze dryer plate temperature control system according to the present invention.
The reference numerals in the figures denote:
1. a freeze dryer sheet layer; 2. a circulation pump; 3. a heater; 4. a heat exchanger; 5. a refrigeration compressor; 61. a first refrigeration liquid supply valve; 62. a second refrigerant supply valve; 71. a first electronic expansion valve; 72. a second electronic expansion valve; 8. a cold trap device; 11. a first temperature detection member; 12. a second temperature detection member.
Detailed Description
The invention will be described in further detail below with reference to the drawings and specific examples.
The flow chart of the freeze dryer plate layer temperature control method of the invention is shown in figure 1: the invention relates to a freeze dryer plate layer temperature control method, which comprises the steps of controlling a refrigeration compressor to work to lower the temperature of a plate layer in a pre-freezing mode, controlling a heater to work to raise the temperature of the plate layer in a sublimation mode, judging whether the refrigeration compressor needs to work and whether the heater needs to work by comparing the sum of the plate layer outlet detection temperature T2 and the system temperature rise delta T with the value of a set reference temperature value in both the pre-freezing mode and the sublimation mode so as to adjust the plate layer inlet detection temperature T1 to be infinitely close to the set reference temperature value T0, converting a medicine from a liquid state to a solid state in the pre-freezing mode, which is a heat release process, taking away heat released by the medicine by the plate layer, wherein the plate layer outlet detection temperature is higher than the plate layer inlet detection temperature T1 after heat exchange, and the system temperature rise delta T generated by a system when a heat medium circulates from a plate layer outlet position to a plate layer inlet, the system does not vibrate and change, therefore, the temperature of the system is judged to be raised or lowered in advance by comparing the sum of the detection temperature T2 of the slab outlet and the temperature rise delta T of the system with the value of the pre-freezing reference temperature value, so that the detection temperature T1 of the slab inlet is infinitely close to the pre-freezing reference temperature value, namely, the temperature control requirement of the pre-freezing mode can be met only through a single process of raising or lowering the temperature, compared with the situation that the temperature is raised or lowered through the detection of the detection temperature T1 of the slab inlet after the hot medium circulates to the position of the slab inlet, the situation that the temperature is raised or lowered due to frequent vibration caused by the hysteresis of the system is avoided, the stability of the system is influenced, and the control process is simple; in the same way, in the sublimation mode, the medicine is from solid-state direct transformation gaseous state, this is an endothermic process, the board layer needs the sublimation of medicine to provide the heat, after the heat transfer, the board layer export detected temperature must be than board layer entry detected temperature T1 low, therefore, through comparing board layer export detected temperature T2 and system temperature rise DeltaT sum and the numerical value size of setting for sublimation reference temperature value, just can judge in advance that the system needs to heat up or lower the temperature and realize that board layer entry detected temperature T1 is unlimited to be close to and set for sublimation reference temperature value, just need the single process of rising temperature or cooling just can satisfy the temperature control demand of sublimation mode, control process is simple high-efficient, and stable and reliable, and high in control accuracy.
In this embodiment, the pre-freezing reference temperature value is set to T0, and the pre-freezing mode includes the following steps:
s101, when T1 is greater than T0, the process goes to step S102;
s102, if T2> T0, the process goes to step S104, and if T2< T0, the process goes to step S103;
s103, if T2 +. DELTA.T > T0, the process proceeds to step S104, and if T2 +. DELTA.T < T0, the heater is controlled to work to heat the slab layer;
and S104, controlling the refrigeration compressor to work to cool the slab layer.
Namely, when the detected temperature T1 of the slab inlet is greater than the preset pre-freezing reference temperature value T0, it indicates that the system needs to be cooled, i.e. enters the pre-freezing mode, but the temperature change condition in the slab is not determined at this time, the operation of the refrigeration compressor and the heater is not started, and whether the refrigeration compressor and the heater are operated or not needs to be controlled through the following steps: if the detected temperature T2 of the slab outlet is greater than the set pre-freezing reference temperature value T0, controlling the refrigeration compressor to work to cool the slab, if the detected temperature T2 of the slab outlet is less than the set pre-freezing reference temperature value T0, further comparing the sum of the detected temperature T2 of the slab outlet and the system temperature rise delta T with the set pre-freezing reference temperature value T0, if the sum of the detected temperature T2 of the slab outlet and the system temperature rise delta T is greater than the set pre-freezing reference temperature value T0, controlling the refrigeration compressor to work to cool the slab, if the sum of the detected temperature T2 of the slab outlet and the system temperature rise delta T is less than the set pre-freezing reference temperature value T0, controlling the heater to work to heat the slab, thereby knowing that, in the pre-freezing mode, by comparing the sum of the detected temperature T2 of the slab outlet and the system temperature rise delta T with the set pre-freezing reference temperature value T0, it can be judged in advance that the system needs to heat or cool down to realize that the detected temperature T1, the temperature control requirement of the pre-freezing mode can be met only through a single process of temperature rising or temperature lowering, the method is simple and reliable, the alternative action of a refrigeration compressor and a heater is avoided, the system is not stable, and the product qualification rate of the freeze dryer is further influenced.
In this embodiment, setting the sublimation reference temperature value as T0' includes the following steps in the sublimation mode:
s201, when T1 is less than T0', the flow proceeds to step S202;
s202, if T2> T0 ', the process goes to step S204, and if T2< T0', the process goes to step S203;
s203, if T2 +. DELTA.T > T0 ', the process proceeds to step S204, and if T2 +. DELTA.T < T0', the heater is controlled to work to heat the slab layer;
and S204, controlling the refrigeration compressor to work to cool the slab layer.
Namely, when the detected temperature T1 of the slab inlet is less than the set sublimation reference temperature value T0', it is indicated that the system needs to be heated, i.e. the system enters the sublimation mode, but the temperature change condition in the slab is not determined at this time, the operation of the refrigeration compressor and the heater is not started, and whether the refrigeration compressor and the heater are operated or not needs to be controlled through the following steps: if the detected temperature T2 of the slab outlet is greater than the set sublimation reference temperature value T0 ', controlling the operation of the refrigeration compressor to cool the slab, if the detected temperature T2 of the slab outlet is less than the set sublimation reference temperature value T0', further comparing the sum of the detected temperature T2 of the slab outlet and the system temperature rise DeltaT with the set sublimation reference temperature value T0 ', if the sum of the detected temperature T2 of the slab outlet and the system temperature rise DeltaT is greater than the set sublimation reference temperature value T0', controlling the operation of the refrigeration compressor to cool the slab, if the sum of the detected temperature T2 of the slab outlet and the system temperature rise DeltaT is less than the set sublimation reference temperature value T0 ', controlling the operation of the heater to heat the slab, thereby knowing that in the sublimation mode, the sum of the detected temperature T2 of the slab outlet and the system temperature rise DeltaT is compared with the set sublimation reference temperature value T0', just can judge in advance that the system needs to heat up or cool down and realize that the board layer entry detects temperature T1 and is infinitely close to and set for sublimation reference temperature value and be T0', the single process that only needs to heat up or cool down just can satisfy the temperature control demand of sublimation mode promptly, and is simple reliable, avoids compressor and heater action in turn, causes the system unstable, and then influences the product percent of pass of freeze dryer.
In this embodiment, before steps S101 and S201, the following steps are further included:
s301, starting a circulating pump;
s302, if the detected circulating pressure difference is not in the set range, sending an alarm signal, and if the detected circulating pressure difference is in the set range, entering the step S303;
s303, turning on a heater power supply and a refrigeration compressor;
and S304, judging to enter a pre-freezing mode or a sublimation mode.
In this embodiment, before steps S101 and S201, a system temperature rise Δ T, which is a temperature rise value of the heat exchange medium when the heat exchange medium circulates from the slab outlet to the slab inlet through the circulation pump, is obtained through actual detection, and the system temperature rise Δ T is measured in advance and is a fixed value and does not change with the adjustment of the system temperature.
In the embodiment, when the refrigeration compressor works, the opening degree of the electronic expansion valve of the refrigeration compressor is adjusted by the PID control method, and when the heater works, the output power of the electric heater is adjusted by the PID control method, so that the control is accurate.
In this embodiment, when the compressor was out of work, automatic switch to cold-trap cooling state, compressor switches between freeze dryer temperature control mode and cold-trap cooling state, when compressor during operation in freeze dryer pre-freezing mode and sublimation mode promptly, the cold-trap cooling does not carry out, and when compressor was out of work in freeze dryer pre-freezing mode and sublimation mode, automatic switch switched to cold-trap cooling mode, because compressor can not frequently start in freeze dryer temperature control mode, the work of cold-trap cooling state is also more stable.
Fig. 2 shows an embodiment of the freeze dryer plate temperature control system of the present invention, the freeze dryer plate temperature control system includes a plate heat exchange loop communicated with a freeze dryer plate 1, the plate heat exchange loop is provided with a circulation pump 2, a heater 3 and a heat exchanger 4 which are sequentially connected in series, the heat exchanger 4 is connected with a refrigeration compressor 5, the plate heat exchange loop is further provided with a first temperature detection piece 11 and a second temperature detection piece 12, the first temperature detection piece 11 is located at an inlet of the freeze dryer plate 1, the second temperature detection piece 12 is located at an outlet of the freeze dryer plate 1, a plate inlet detection temperature T1 is obtained through the first temperature detection piece 11, a plate outlet detection temperature T2 is obtained through the second temperature detection piece, i.e. by comparing a sum of a plate outlet detection temperature T2 and a system temperature rise Δ T with a set reference temperature value, whether the refrigeration compressor 2 needs to operate and whether the heater 3 needs to operate or not can be determined, the detection temperature T1 of the inlet of the adjusting plate layer is infinitely close to the set reference temperature value, so that the plate layer temperature control system of the freeze dryer disclosed by the invention is stable in work, convenient to control and high in temperature control precision, and the production yield of the freeze dryer can be improved.
In this embodiment, a pipeline through which the refrigeration compressor 5 is communicated with the heat exchanger 4 is provided with a first refrigeration liquid supply valve 61 and a first electronic expansion valve 71 which are connected in series, a PID controller of the refrigeration compressor 5 is communicated with the electronic expansion valve 62, the heater 3 comprises a PID controller, the opening degree of the electronic expansion valve 62 is controlled by the PID controller, the output proportion of the heater 3 is controlled by the PID controller, and the control is very accurate and efficient.
In this embodiment, the freeze dryer plate layer temperature control system further includes a cold trap device 8, the cold trap device 8 is communicated with the refrigeration compressor 5, a second refrigeration liquid supply valve 62 and a second electronic expansion valve 72 are arranged on a communication pipeline, and the refrigeration compressor 2 is switched between the freeze dryer temperature control mode and the cold trap temperature reduction state through the first refrigeration liquid supply valve 61, the first electronic expansion valve 71, the second refrigeration liquid supply valve 62 and the second electronic expansion valve 72.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make numerous possible variations and modifications to the present invention, or modify equivalent embodiments to equivalent variations, without departing from the scope of the invention, using the teachings disclosed above. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical spirit of the present invention should fall within the protection scope of the technical scheme of the present invention, unless the technical spirit of the present invention departs from the content of the technical scheme of the present invention.
Claims (5)
1. The utility model provides a freeze dryer sheet layer temperature control method, in the mode of freezing in advance, controls the work of compressor and makes the sheet layer cooling, and in the sublimation mode, control heater work makes the sheet layer heat up, its characterized in that: in the pre-freezing mode and the sublimation mode, whether the refrigeration compressor needs to work and whether the heater needs to work are judged by comparing the sum of the detected temperature T2 at the outlet of the slab layer and the temperature rise delta T of the system with the value of the set reference temperature value, so that the detected temperature T1 at the inlet of the slab layer is adjusted to be infinitely close to the set reference temperature value, and the set pre-freezing reference temperature value is T0, wherein the pre-freezing mode comprises the following steps:
s101, when T1 is greater than T0, the process goes to step S102;
s102, if T2> T0, the process goes to step S104, and if T2< T0, the process goes to step S103;
s103, if T2+ delta T > T0, the process goes to step S104, and if T2+ delta T < T0, the heater is controlled to work to heat the slab layer;
s104, controlling the refrigeration compressor to work to cool the slab layer;
setting a sublimation reference temperature value as T0', wherein the sublimation mode comprises the following steps:
s201, when T1 is less than T0', the flow proceeds to step S202;
s202, if T2> T0 ', the process goes to step S204, and if T2< T0', the process goes to step S203;
s203, if T2+ delta T > T0 ', the process goes to step S204, and if T2+ delta T < T0', the heater is controlled to work to heat the slab layer;
and S204, controlling the refrigeration compressor to work to cool the slab layer.
2. The method for controlling a temperature of a freeze dryer sheet layer according to claim 1, further comprising, before the steps S101 and S201, the steps of:
s301, starting a circulating pump;
s302, if the detected circulating pressure difference is not in the set range, sending an alarm signal, and if the detected circulating pressure difference is in the set range, entering the step S303;
s303, turning on a heater power supply and a refrigeration compressor;
and S304, judging to enter a pre-freezing mode or a sublimation mode.
3. The method for controlling the temperature of a freeze dryer sheet layer according to claim 1 or 2, wherein: before the steps S101 and S201, a temperature rise value, i.e., a system temperature rise Δ T, of the heat exchange medium when the heat exchange medium circulates from the slab outlet to the slab inlet through the circulation pump is obtained through actual detection.
4. The method for controlling the temperature of a freeze dryer sheet layer according to claim 1 or 2, wherein: when the refrigeration compressor works, the opening degree of an electronic expansion valve of the refrigeration compressor is adjusted by a PID control method, and when the heater works, the output power of the electric heater is adjusted by the PID control method.
5. The method for controlling the temperature of a freeze dryer sheet layer according to claim 1 or 2, wherein: and when the refrigeration compressor does not work, the refrigeration compressor is automatically switched to a cold trap cooling state.
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| CN109883162A (en) * | 2019-02-22 | 2019-06-14 | 上海卫星装备研究所 | Cold-hot integrated formula vacuum freeze-drying machine |
| CN114322464A (en) * | 2020-09-30 | 2022-04-12 | 浙江同景新能源集团有限公司 | Cold trap system of freeze-drying equipment |
| EP4053481A1 (en) * | 2021-03-05 | 2022-09-07 | GEA Lyophil GmbH | A freeze dryer and a method for operating a freeze dryer |
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| JPS6273068A (en) * | 1985-09-25 | 1987-04-03 | 株式会社日立製作所 | Method of controlling refrigerator |
| US6971187B1 (en) * | 2002-07-18 | 2005-12-06 | University Of Connecticut | Automated process control using manometric temperature measurement |
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| CN206399029U (en) * | 2017-01-11 | 2017-08-11 | 山东新华医疗器械股份有限公司 | A kind of freeze dryer and its refrigeration system |
| CN206944585U (en) * | 2017-06-02 | 2018-01-30 | 大连双瑞科技有限公司 | The cold and hot freeze drying box integrally controlled |
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Application publication date: 20190104 Assignee: Changsha Pharmaceutical Equipment Industrial Technology Research Institute Co.,Ltd. Assignor: TRUKING TECHNOLOGY Ltd. Contract record no.: X2023980051833 Denomination of invention: Temperature control method and system for freeze-drying machine board layer Granted publication date: 20210302 License type: Common License Record date: 20231213 |