CN109134336B - 二芳醚类化合物及其制备方法和应用 - Google Patents
二芳醚类化合物及其制备方法和应用 Download PDFInfo
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- CN109134336B CN109134336B CN201711025294.3A CN201711025294A CN109134336B CN 109134336 B CN109134336 B CN 109134336B CN 201711025294 A CN201711025294 A CN 201711025294A CN 109134336 B CN109134336 B CN 109134336B
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- diaryl ether
- ether compound
- tert
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Fats And Perfumes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
实施例 | B4 | M1 | M2 | M3 | M4 |
30 | 4-异丙基溴苯 | 1:1 | 1:1 | 1:1.2 | 1:0.8 |
31 | 4-氰基溴苯 | 1:1 | 1:1 | 1:1.4 | 1:0.9 |
32 | 4-乙氧基溴苯 | 1:1.1 | 1:1.3 | 1:1.5 | 1:1 |
33 | 4-甲氧基溴苯 | 1:1.1 | 1:1.3 | 1:1.6 | 1:1.3 |
34 | 3-甲氧基溴苯 | 1:1.2 | 1:1.5 | 1:1.8 | 1:1.5 |
实施例 | IC50(μM)) | 实施例 | IC50(μM) |
4 | 5.05 | 16 | 0.91 |
5 | 1.18 | 18 | 5.85 |
7 | 1.83 | 22 | 0.35 |
8 | 2.16 | 27 | 5.04 |
9 | 0.48 | 28 | 2.87 |
11 | 1.25 | 29 | 0.32 |
12 | 0.28 | 30 | 1.09 |
13 | 1.15 | 32 | 2.91 |
14 | 3.89 | 33 | 2.98 |
15 | 0.95 |
Claims (10)
Priority Applications (1)
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CN201711025294.3A CN109134336B (zh) | 2017-10-27 | 2017-10-27 | 二芳醚类化合物及其制备方法和应用 |
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CN201711025294.3A CN109134336B (zh) | 2017-10-27 | 2017-10-27 | 二芳醚类化合物及其制备方法和应用 |
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CN109134336A CN109134336A (zh) | 2019-01-04 |
CN109134336B true CN109134336B (zh) | 2021-08-03 |
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CN201711025294.3A Active CN109134336B (zh) | 2017-10-27 | 2017-10-27 | 二芳醚类化合物及其制备方法和应用 |
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CN (1) | CN109134336B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA53433A (fr) * | 2018-08-24 | 2021-06-30 | Xeniopro GmbH | Éthers phénoxy(hétéro)aryle à activité antiproliférative |
WO2021092893A1 (zh) * | 2019-11-15 | 2021-05-20 | 北京大学深圳研究生院 | 二芳醚类化合物在制备抗肿瘤药物中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
CN102256944A (zh) * | 2008-10-17 | 2011-11-23 | 埃克塞利希斯股份有限公司 | 鞘氨醇-1-磷酸受体拮抗剂 |
-
2017
- 2017-10-27 CN CN201711025294.3A patent/CN109134336B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
CN102256944A (zh) * | 2008-10-17 | 2011-11-23 | 埃克塞利希斯股份有限公司 | 鞘氨醇-1-磷酸受体拮抗剂 |
Non-Patent Citations (7)
Title |
---|
1006030-43-8/rn;-;《STN Registry》;20080302 * |
1131041-32-1/rn;-;《STN Registry》;20090402 * |
1582013-41-9/rn;-;《STN Registry》;20140408 * |
1582964-97-3/rn;-;《STN Registry》;20140410 * |
1583903-68-7/rn;-;《STN Registry》;20140413 * |
1589778-81-3/rn;-;《STN Registry》;20140424 * |
Structure-Based Designof Potentand Selective Inhibitors of the Metabolic Kinase PFKFB3;Scott Boyd 等;《Journal of Medicinal Chemistry》;20150407;第58卷;第3611-3625页 * |
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