CN109125913A - A kind of medical scar plaster of drug containing and preparation method thereof - Google Patents
A kind of medical scar plaster of drug containing and preparation method thereof Download PDFInfo
- Publication number
- CN109125913A CN109125913A CN201811308359.XA CN201811308359A CN109125913A CN 109125913 A CN109125913 A CN 109125913A CN 201811308359 A CN201811308359 A CN 201811308359A CN 109125913 A CN109125913 A CN 109125913A
- Authority
- CN
- China
- Prior art keywords
- drug containing
- medical
- layer
- drug
- silicon rubber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
The present invention relates to medical scar plasters of a kind of drug containing and preparation method thereof.This product structure is, using the side close to the surface of a wound as internal layer, successively bonding is centrifuged film, drug containing silicon gel layer, silicon rubber film layer, non-woven fabrics from inside to outside；Or, successively bonding is centrifuged film, drug containing silicon gel layer, non-woven fabrics, silicon rubber film layer from inside to outside.Contain drug in the Silica hydrogel, the administration mode that tradition smears drug is changed to slowly permeate by the present invention, promotes the absorption of drug, discharge sustained drug, the drug containing silicon gel layer and silicon rubber film layer along its length on section be arc.Silicon rubber film layer has been evenly distributed in the upper surface micropore, and gas permeability is strong, discharges the vapor in pore by micropore, increases skin comfort degree, enhances therapeutic effect.Preparation method of the present invention is simple, process costs are low, is suitble to large-scale production and application.
Description
Technical field
The present invention relates to the technical fields of medical instrument, and in particular to a kind of medical scar plaster of drug containing and its preparation side
Method.
Background technique
Scar is the inevitable outcome after various wound healings, if but healing is insufficient or healing is excessive, i.e., it can generate scar
Trace can occur to become hyperplastic scar if scar continues to be proliferated.According to the various extent of injury for causing damage factor, Yi Jishou
The constitution of the wounded can lead to following a few class scars: the shallow scars of table, atrophic scar, depressed scar, hyperplastic scar, scar
Trace pimple, the especially people of scar constitution, scar are especially apparent.Scar can bring great inconvenience to patient, as burn causes
Hyperplastic scar, local itch, pain or even dysfunction can be caused, seriously perplex patient.
Silica hydrogel desalinates scar method after more tying as wound originates in the eighties in last century, uses this method in foreign countries
The product wide application of softening and desalination scar.Silica hydrogel can enable scar keep a degree of temperature, pressure, oxygen
Amount, can soften scar, improve and prevent to operate on because of burn, scald, operation or other wounds caused by Hypertrophic and scar tumor
Scar；It is praised highly by health care workers all over the world.Conventional medical scar plaster is mostly the uniform tablet of thin and thick, and application method is
Drug first to be smeared, then scar plaster is labelled at scar, usage comfort is inadequate, and slow effect, poor air permeability, therapeutic effect is bad,
For conventional medical scar plaster there are also medicine storing bag is increased in gel layer, preparation process is complicated, at high price, increases the expense of patient
Burden, prevents Silica hydrogel scar plaster from being widely used.
Therefore, it is low in cost to develop one kind, it is quick, outside the high operation that can be used in clinical medicine of usage comfort
Wound, the medical scar plaster that burn and scald healing later period hyperplastic scar prevents and treats is asking for those skilled in the art's urgent need to resolve
Topic.
Summary of the invention
The present invention overcomes the disadvantages described above of the prior art, provides a kind of low in cost, and quick, usage comfort is high
It can be used in the surgery trauma of clinical medicine, the medical scar plaster that burn and scald healing later period hyperplastic scar prevents and treats.
The technical scheme to solve the above technical problems is that
A kind of medical scar plaster of drug containing, including centrifugation film 1, drug containing silicon gel layer 2, silicon rubber film layer 3, non-woven fabrics
4, using the side close to the surface of a wound as internal layer, the centrifugation film 1, drug containing silicon gel layer 2, silicon rubber film layer 3, non-woven fabrics 4 are successively
It is bonded from inside to outside；
Or, the centrifugation film 1, drug containing silicon gel layer 2, non-woven fabrics 4, silicon rubber film layer 3 be successively bonded from the inside to the outside and
At；
The drug containing silicon gel layer and silicon rubber film layer along its length on section be arc.
The present invention having the beneficial effect that by adopting the above technical scheme contains drug in the Silica hydrogel, the present invention will be traditional
The administration mode for smearing drug is changed to slowly permeate, and promotes the absorption of drug, discharges sustained drug, quick.
The drug containing silicon gel layer and silicon rubber film layer along its length on section be arc.
The side along its length of the medical scar plaster for having the beneficial effect that the drug containing of the present invention by adopting the above technical scheme
Upward section is arc.It being fitted closely with human skin, expulsion rate is low, increases user's skin comfort degree, and it is long using the time,
Enhance therapeutic effect.
The silicone rubber membrane has been evenly distributed in the upper surface micropore, and aperture is 1.5 ± 0.5mm.
The present invention by adopting the above technical scheme have the beneficial effect that silicone rubber membrane has been evenly distributed in the upper surface micropore, make in pore
Vapor pass through micropore discharge, increase skin comfort degree, enhance therapeutic effect.
The centrifugation film 1, drug containing silicon gel layer 2, non-woven fabrics 4, silicon rubber film layer 3 are successively bonded from the inside to the outside
When, the silicon rubber film layer is equipped with netted anti-sticking line far from the side of the surface of a wound.Netted anti-sticking line, which plays, to be reduced silastic-layer and makes
Frictional force effect between the worn fabric of user.
Any one of rectangular, round or irregular shape is made in the medical scar plaster of the drug containing.
Each thickness degree of medical scar plaster is respectively as follows: centrifugation film 0.07-0.1mm, drug containing silicon gel layer 0.2-
2.0mm, silicon rubber film layer 0.07-0.12mm, non-woven fabrics 0.01-0.15mm.
Drug ingedient in the drug containing silicon gel layer 2 are as follows: every m2How is the medical scar plaster Qu An containing acetic acid of drug containing
Moral 0.16g, vitamin B1 1.5g。
The pellosil of the medical scar plaster of the drug containing is transparent, translucent, the colour of skin or any one of cream-coloured.
The medical scar plaster of the drug containing contains rose or Peppermint essential oil, there is faint scent.
A kind of preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) non-woven fabrics is covered in vacuum arcuate die, medical grade silicon rubber roller coating is prepared into silicon rubber on Teflon film cloth
Adhesive film carries out primary vulcanization and post-cure, and demoulding is put into vacuum arcuate die and is overlaid on nonwoven surface, spare；
2) drug containing Silica hydrogel is coated in the silicon rubber film layer of step 1), is formed drug containing silicon gel layer (2), is put into
In vacuum arcuate die, solidification；
3) centrifugation membrane pressure is overlying on to the surface of the drug containing silicon gel layer of step 2), is cut to required specification area；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Or, 1) medical grade silicon rubber roller coating is prepared silicon rubber film layer on Teflon film cloth, primary vulcanization and two is carried out
Silicone rubber membrane lamination is overlayed in vacuum arcuate die, non-woven fabrics is put into vacuum arcuate die and is overlaid on by secondary vulcanization, demoulding
Silicone rubber membrane layer surface, it is spare；
2) drug containing Silica hydrogel is coated on the non-woven fabrics of step 1), forms drug containing silicon gel layer 2, is put into Vacuum Arc
In shape mold, solidification；
3) centrifugation membrane pressure is overlying on to the surface of the drug containing silicon gel layer of step 2), is cut to required specification area；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
In the step 1), the primary vulcanization time is 100-130min, and curing temperature is 160-190 DEG C；Post-cure
Time be 15-30min, curing temperature be 140-150 DEG C.
In the step 2), the preparation method of drug containing silicon gel layer 2 includes: that isomery dodecane and silicon are added into drug
Oil carries out vacuum emulsification, emulsification times 25-30min, and emulsifying temperature is 25 ± 2 DEG C, stirs evenly afterwards with Medical silicone gels,
Mixing time is 25-30min, and whipping temp is 25 ± 2 DEG C to get drug containing Silica hydrogel, and drug containing Silica hydrogel is coated on step
Drug containing silicon gel layer is formed in rapid silicon rubber film layer or non-woven fabrics 1).
In the step 2), every m2The drug containing silicon gel layer of the medical scar plaster of drug containing contains Silica hydrogel 500g, vinegar
Sour Triamcinolone acetonide 0.16g, vitamin B11.5g, isomery dodecane 200g, silicone oil 150g.
In the step 2), solidification temperature is 80-120 DEG C, curing time 8-12min.
The present invention by adopting the above technical scheme have the beneficial effect that preparation method of the present invention is simple, process costs are low, be suitble to
Large-scale production and application.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the medical scar plaster of drug containing of the present invention.
Fig. 2 is the structural schematic diagram of the medical scar plaster of another drug containing of the present invention.
In attached drawing 1, structure list representated by each label is as follows:
1, film 2, drug containing silicon gel layer 3, silicon rubber film layer 4, non-woven fabrics are centrifuged
In attached drawing 2, structure list representated by each label is as follows:
1, film 2, drug containing silicon gel layer 3, non-woven fabrics 4, silicon rubber film layer are centrifuged
Specific embodiment
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
Be detailed in attached drawing, the medical scar plaster of drug containing, using the side close to the surface of a wound as internal layer, be successively bonded from inside to outside from
Heart film 1, drug containing silicon gel layer 2, silicon rubber film layer 3, non-woven fabrics 4；
Or, successively bonding is centrifuged film 1, drug containing silicon gel layer 2, non-woven fabrics 4, silicon rubber film layer 3 from inside to outside；
The drug containing silicon gel layer and silicon rubber film layer along its length on section be arc.
The silicon rubber film layer has been evenly distributed in the upper surface micropore, and aperture is 1.5 ± 0.5mm.
The centrifugation film 1, drug containing silicon gel layer 2, non-woven fabrics 4, silicon rubber film layer 3 are successively bonded from the inside to the outside
When, the silicon rubber film layer is equipped with netted anti-sticking line far from the side of the surface of a wound.
Each thickness degree of medical scar plaster is respectively as follows: centrifugation film 0.07-0.1mm, drug containing silicon gel layer 0.2-
2.0mm, silicon rubber film layer 0.07-0.12mm, non-woven fabrics 0.01-0.15mm.
Drug ingedient in the drug containing silicon gel layer 2 are as follows: every m2How is the medical scar plaster Qu An containing acetic acid of drug containing
Moral 0.16g, vitamin B1 1.5g。
The preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) non-woven fabrics is covered in vacuum arcuate die, medical grade silicon rubber roller coating is prepared into silicon rubber on Teflon film cloth
Adhesive film carries out primary vulcanization and post-cure, and demoulding is put into vacuum arcuate die and is overlaid on nonwoven surface, spare；
2) drug containing Silica hydrogel is coated in the silicon rubber film layer of step 1), forms drug containing silicon gel layer 2, be put into true
In empty arcuate die, solidification；
3) centrifugation membrane pressure is overlying on to the surface of the drug containing silicon gel layer of step 2), is cut to required specification area；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Or, 1) medical grade silicon rubber roller coating is prepared silicon rubber film layer on Teflon film cloth, primary vulcanization and two is carried out
Silicone rubber membrane lamination is overlayed in vacuum arcuate die, non-woven fabrics is put into vacuum arcuate die and is overlaid on by secondary vulcanization, demoulding
Silicone rubber membrane layer surface, it is spare；
2) drug containing Silica hydrogel is coated on the non-woven fabrics of step 1), is formed drug containing silicon gel layer (2), is put into vacuum
In arcuate die, solidification；
3) centrifugation membrane pressure is overlying on to the surface of the drug containing silicon gel layer of step 2), is cut to required specification area；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
In the step 1), the primary vulcanization time is 100-130min, and curing temperature is 160-190 DEG C；Post-cure
Time be 15-30min, curing temperature be 140-150 DEG C.
In the step 2), the preparation method of drug containing silicon gel layer 2 includes: that isomery dodecane and silicon are added into drug
Oil carries out vacuum emulsification, emulsification times 25-30min, and emulsifying temperature is 25 ± 2 DEG C, stirs evenly afterwards with Medical silicone gels,
Mixing time is 25-30min, and whipping temp is 25 ± 2 DEG C to get drug containing Silica hydrogel, and drug containing Silica hydrogel is coated on step
Drug containing silicon gel layer is formed in rapid silicon rubber film layer or non-woven fabrics 1).
In the step 2), every m2The drug containing silicon gel layer of the medical scar plaster of drug containing contains Silica hydrogel 500g, vinegar
Sour Triamcinolone acetonide 0.16g, vitamin B11.5g, isomery dodecane 200g, silicone oil 150g.
In the step 2), solidification temperature is 80-120 DEG C, curing time 8-12min.
Embodiment 1
The medical scar plaster of drug containing successively includes from inside to outside centrifugation film 1, contains using the side close to the surface of a wound as internal layer
Drug silicon gel layer 2, silicon rubber film layer 3, non-woven fabrics 4.The drug containing silicon gel layer 2 and silicon rubber film layer 3 are square along its length
Upward section is arc.The silicone rubber membrane has been evenly distributed in the upper surface micropore, aperture 1.5mm.The medical scar of the drug containing
It is rectangular that 200mm × 200mm is made in trace patch.Each thickness degree of medical scar plaster is respectively as follows: centrifugation film 0.07mm, and drug containing silicon is solidifying
Glue-line 0.2mm, silicon rubber film layer 0.07mm, non-woven fabrics 0.01mm.The drug ingedient of the medical scar plaster of the drug containing by
Following parts by weight drug composition:
Every m2Medical scar plaster 0.16g containing triamcinolone acetonide acetate, the vitamin B of drug containing1 1.5g
The preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) non-woven fabrics is covered in vacuum arcuate die, medical grade silicon rubber roller coating is prepared into silicon rubber on Teflon film cloth
Adhesive film, coating layer thickness 0.07mm carry out primary vulcanization, vulcanization time 120min, and curing temperature is 180 DEG C, then
Post-cure, vulcanization time 20min, curing temperature are 150 DEG C of demouldings, are put into vacuum mold and are overlaid on nonwoven surface,
It is spare；
2) drug containing silicon gel layer is prepared, isomery dodecane and silicone oil, every m are added in the drug for the treatment of scar hyperplasia2Contain
Each component in the medical scar plaster of drug are as follows: Silica hydrogel 500g, triamcinolone acetonide acetate 0.16g, vitamin B11.5g, isomery ten
Dioxane 200g, silicone oil 150g carry out vacuum emulsification, emulsification times 25min, and emulsifying temperature is 23 DEG C, afterwards and Medical silicone gels
It stirring evenly, mixing time 25min, whipping temp is 23 DEG C, it is scratched, is coated in the silicon rubber film layer of step 1),
Coating layer thickness is 0.2mm, is put into vacuum mold, solidification, and solidification temperature is 100 DEG C, curing time 10min；
3) centrifugation membrane pressure is overlying on to the surface of drug containing silicon gel layer obtained by step 2), is cut to 200mm × 200mm's
It is rectangular；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Embodiment 2
The medical scar plaster of drug containing successively includes from inside to outside centrifugation film 1, contains using the side close to the surface of a wound as internal layer
Drug silicon gel layer 2, silicone rubber membrane 3, non-woven fabrics 4.The drug containing silicon gel layer 2 and silicon rubber film layer 3 are along its length
On section be arc.The silicone rubber membrane has been evenly distributed in the upper surface micropore, aperture 2.0mm.The medical scar of the drug containing
The circle that radius is 200mm is made in patch.Each thickness degree of medical scar plaster is respectively as follows: centrifugation film 0.1mm, drug containing Silica hydrogel
Layer 2.0mm, silicon rubber film layer 0.12mm, non-woven fabrics 0.15mm.The drug ingedient of the medical scar plaster of the drug containing by with
Lower parts by weight drug composition:
Every m2Medical scar plaster 0.16g containing triamcinolone acetonide acetate, the vitamin B of drug containing1 1.5g。
The preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) non-woven fabrics is covered in vacuum arcuate die, medical grade silicon rubber roller coating is prepared into silicon rubber on Teflon film cloth
Adhesive film, coating layer thickness 0.12mm carry out primary vulcanization, vulcanization time 100min, and curing temperature is 160 DEG C, then
Post-cure, vulcanization time 15min, curing temperature are 140 DEG C of demouldings, are put into vacuum mold and are overlaid on nonwoven surface,
It is spare；
2) drug containing silicon gel layer is prepared, isomery dodecane and silicone oil, every m are added in the drug for the treatment of scar hyperplasia2Contain
Each component in the medical scar plaster of drug are as follows: Silica hydrogel 500g, triamcinolone acetonide acetate 0.16g, vitamin B11.5g, isomery ten
Dioxane 200g, silicone oil 150g carry out vacuum emulsification.Emulsification times are 30min, and emulsifying temperature is 27 DEG C, afterwards and Medical silicone gels
It stirring evenly, mixing time 25min, whipping temp is 23 DEG C, it is scratched, is coated in the silicon rubber film layer of step 1),
Coating layer thickness is 2.0mm, is put into vacuum mold, solidification, and solidification temperature is 80 DEG C, curing time 8min；
3) centrifugation membrane pressure is overlying on to the surface of drug containing silicon gel layer obtained by step 2), cutting to radius is 200mm's
It is round；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Embodiment 3
The medical scar plaster of drug containing successively includes from inside to outside centrifugation film 1, contains using the side close to the surface of a wound as internal layer
Drug silicon gel layer 2, silicone rubber membrane 3, non-woven fabrics 4.The drug containing silicon gel layer 2 and silicon rubber film layer 3 are along its length
On section be arc.It is evenly equipped with micropore above the silicone rubber membrane, pore diameter range is within the scope of 1.8mm.The drug containing
The rectangle of 50mm × 200mm is made in medical scar plaster.Each thickness degree of medical scar plaster is respectively as follows: centrifugation film 0.08mm,
Drug containing silicon gel layer 0.6mm, silicon rubber film layer 0.1mm, non-woven fabrics 0.11mm.The medicine of the medical scar plaster of the drug containing
Object ingredient is made of following parts by weight drug:
Every m2Medical scar plaster 0.16g containing triamcinolone acetonide acetate, the vitamin B of drug containing1 1.5g。
The preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) non-woven fabrics is covered in vacuum arcuate die, medical grade silicon rubber roller coating is prepared into silicon rubber on Teflon film cloth
Adhesive film, coating layer thickness 0.1mm carry out primary vulcanization, vulcanization time 130min, and curing temperature is 190 DEG C, and then two
Secondary vulcanization, vulcanization time 30min, curing temperature are 145 DEG C of demouldings, are put into vacuum mold and are overlaid on nonwoven surface, standby
With；
2) drug containing silicon gel layer is prepared, isomery dodecane and silicone oil (every m are added in the drug for the treatment of scar hyperplasia2Contain
Each component in the medical scar plaster of drug are as follows: Silica hydrogel 500g, triamcinolone acetonide acetate 0.16g, vitamin B11.5g, isomery ten
Dioxane 200g, silicone oil 150g carry out vacuum emulsification, emulsification times 28min, and emulsifying temperature is 26 DEG C, afterwards and Medical silicone gels
It stirs evenly, mixing time 26min, whipping temp: 26 DEG C, being scratched, is coated in the silicon rubber film layer of step 1), applied
Layer is put into vacuum mold with a thickness of 0.6mm, is solidified, and solidification temperature is 120 DEG C, curing time 12min；
3) centrifugation membrane pressure is overlying on to the surface of drug containing silicon gel layer obtained by step 2), is cut to 50mm × 200mm's
Rectangle；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Embodiment 4
The medical scar plaster of drug containing successively includes from inside to outside centrifugation film 1, contains using the side close to the surface of a wound as internal layer
Drug silicon gel layer 2, non-woven fabrics 4, silicon rubber film layer 3.The drug containing silicon gel layer 2 and silicon rubber film layer 3 are square along its length
Upward section is arc.The silicone rubber membrane has been evenly distributed in the upper surface micropore, and pore diameter range is within the scope of 1.3mm.The silicon rubber
Side on glue film far from the surface of a wound is equipped with netted anti-sticking line, and netted anti-sticking line plays reduction silastic-layer and worn with user
Frictional force effect between fabric.It is rectangular that 200mm × 200mm is made in the medical scar plaster of the drug containing.The medical scar plaster
Each thickness degree is respectively as follows: centrifugation film 0.09mm, drug containing silicon gel layer 0.8mm, silicon rubber film layer 0.11mm, non-woven fabrics
0.09mm.The drug ingedient of the medical scar plaster of the drug containing is made of following parts by weight drug:
Every m2Medical scar plaster 0.16g containing triamcinolone acetonide acetate, the vitamin B of drug containing1 1.5g。
The preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) medical grade silicon rubber roller coating is prepared on Teflon film cloth silicon rubber film layer, carries out primary vulcanization and secondary sulphur
Change, coating layer thickness 0.1mm, carry out primary vulcanization, vulcanization time 120min, curing temperature is 180 DEG C, then secondary sulphur
Change, vulcanization time 20min, curing temperature is 150 DEG C, demoulding, silicone rubber membrane lamination is overlayed in vacuum arcuate die, by nothing
Woven fabric, which is put into vacuum arcuate die, is overlaid on silicone rubber membrane layer surface, spare；
2) drug containing silicon gel layer is prepared, isomery dodecane and silicone oil, every m are added in the drug for the treatment of scar hyperplasia2Contain
Each component in the medical scar plaster of drug are as follows: Silica hydrogel 500g, triamcinolone acetonide acetate 0.16g, vitamin B11.5g, isomery ten
Dioxane 200g, silicone oil 150g carry out vacuum emulsification, emulsification times 28min, and emulsifying temperature is 27 DEG C, afterwards and Medical silicone gels
It stirs evenly, mixing time 28min, whipping temp: 25 DEG C, being scratched, be coated on the non-woven fabrics of step 1), apply thickness
Degree is 0.8mm, is put into vacuum mold, is solidified, and solidification temperature is 100 DEG C, curing time 10min；
3) centrifugation membrane pressure is overlying on to the surface of drug containing silicon gel layer obtained by step 2), is cut to 200mm × 200mm's
It is rectangular；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Embodiment 5
The medical scar plaster of drug containing successively includes from inside to outside centrifugation film 1, contains using the side close to the surface of a wound as internal layer
Drug silicon gel layer 2, non-woven fabrics 4, silicone rubber membrane 3.The drug containing silicon gel layer 2 and silicon rubber film layer 3 are along its length
On section be arc.The silicone rubber membrane has been evenly distributed in the upper surface micropore, and pore diameter range is within the scope of 1.3mm.The silicon rubber
Side on film far from the surface of a wound is equipped with netted anti-sticking line, and netted anti-sticking line, which plays, to be reduced silastic-layer and wear and knit with user
Frictional force effect between object.The circle that radius is 200mm is made in the medical scar plaster of the drug containing.The medical scar plaster is each
Thickness degree is respectively as follows: centrifugation film 0.1mm, drug containing silicon gel layer 1.8mm, silicon rubber film layer 0.10mm, non-woven fabrics 0.10mm.Institute
The drug ingedient of the medical scar plaster for the drug containing stated is made of following parts by weight drug:
Every m2Medical scar plaster 0.16g containing triamcinolone acetonide acetate, the vitamin B of drug containing1 1.5g。
The preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) medical grade silicon rubber roller coating is prepared on Teflon film cloth silicon rubber film layer, carries out primary vulcanization and secondary sulphur
Change, coating layer thickness 0.1mm, carry out primary vulcanization, vulcanization time 100min, curing temperature is 160 DEG C, then secondary sulphur
Change, vulcanization time 15min, curing temperature is 140 DEG C of demouldings, silicone rubber membrane lamination is overlayed in vacuum arcuate die, by nothing
Woven fabric, which is put into vacuum arcuate die, is overlaid on silicone rubber membrane layer surface, spare；
2) drug containing silicon gel layer is prepared, isomery dodecane and silicone oil, every m are added in the drug for the treatment of scar hyperplasia2Contain
Each component in the medical scar plaster of drug are as follows: Silica hydrogel 500g, triamcinolone acetonide acetate 0.16g, vitamin B11.5g, isomery ten
Dioxane 200g, silicone oil 150g carry out vacuum emulsification, emulsification times 28min, and emulsifying temperature is 23 DEG C, afterwards and Medical silicone gels
It stirring evenly, mixing time 28min, whipping temp is 27 DEG C, it is scratched, is coated on the non-woven fabrics of step 1), coating
It with a thickness of 1.0mm, is put into vacuum mold, solidifies, solidification temperature is 80 DEG C, curing time 10min；
3) centrifugation membrane pressure is overlying on to the surface of drug containing silicon gel layer obtained by step 2), cutting to radius is 200mm's
It is round；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Embodiment 6
The medical scar plaster of drug containing successively includes from inside to outside centrifugation film 1, contains using the side close to the surface of a wound as internal layer
Drug silicon gel layer 2, non-woven fabrics 4, silicone rubber membrane 3.The drug containing silicon gel layer 2 and silicon rubber film layer 3 are along its length
On section be arc.Micropore, aperture 2.0mm are evenly equipped with above the silicone rubber membrane.Far from the surface of a wound on the silicone rubber membrane
Side be equipped with netted anti-sticking line, netted anti-sticking line plays the frictional force reduced between silastic-layer and the worn fabric of user
Effect.The rectangle of 50mm × 200mm is made in the medical scar plaster of the drug containing.Each thickness degree difference of medical scar plaster
Are as follows: centrifugation film 0.1mm, drug containing silicon gel layer 1.8mm, silicon rubber film layer 0.11mm, non-woven fabrics 0.10mm.The drug containing
The drug ingedient of medical scar plaster be made of following parts by weight drug:
Every m2Medical scar plaster 0.16g containing triamcinolone acetonide acetate, the vitamin B of drug containing1 1.5g。
The preparation method of the medical scar plaster of drug containing, comprising the following steps:
1) medical grade silicon rubber roller coating is prepared into silicon rubber film layer on Teflon film cloth, coating layer thickness 0.1mm carries out the
Primary vulcanization, vulcanization time 130min, curing temperature are 190 DEG C, then post-cure, vulcanization time 30min, vulcanization temperature
Degree is 145 DEG C of demouldings, and silicone rubber membrane lamination is overlayed in vacuum arcuate die, non-woven fabrics is put into vacuum arcuate die and is covered
It is spare in silicone rubber membrane layer surface；
2) drug containing silicon gel layer is prepared, isomery dodecane and silicone oil, every m are added in the drug for the treatment of scar hyperplasia2Contain
Each component in the medical scar plaster of drug are as follows: Silica hydrogel 500g, triamcinolone acetonide acetate 0.16g, vitamin B11.5g, isomery ten
Dioxane 200g, silicone oil 150g carry out vacuum emulsification, emulsification times 30min, and emulsifying temperature is 25 DEG C, afterwards and Medical silicone gels
It stirs evenly, mixing time 25min, 27 DEG C of whipping temp, is scratched, be coated on the non-woven fabrics of step 1), apply thickness
Degree is 2.0mm, is put into vacuum mold, is solidified, and solidification temperature is 120 DEG C, curing time 12min；
3) centrifugation membrane pressure is overlying on to the surface of drug containing silicon gel layer obtained by step 2), is cut to 50mm × 200mm's
Rectangle；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Performance test
1. detection project:
The medical scar plaster of drug containing made from embodiment 1
The medical scar plaster of drug containing made from embodiment 2
The medical scar plaster of drug containing made from embodiment 3
The medical scar plaster of drug containing made from embodiment 4
The medical scar plaster of drug containing made from embodiment 5
The medical scar plaster of drug containing made from embodiment 6
Comparative example:
Common medical scar plaster successively includes centrifugation film, Silica hydrogel using the side close to the surface of a wound as internal layer from inside to outside
Layer, silicon rubber film layer, non-woven fabrics.Medical scar plaster is made to the rectangle of 50mm × 200mm.Each thickness of medical scar plaster
Degree is respectively as follows: centrifugation film 0.1mm, drug containing silicon gel layer 1.8mm, silicon rubber film layer 0.11mm, non-woven fabrics 0.10mm.
The preparation method of common medical scar plaster, comprising the following steps:
1) non-woven fabrics is covered in vacuum mold, medical grade silicon rubber roller coating is prepared into silicone rubber membrane on Teflon film cloth
Layer, coating layer thickness 0.11mm carry out primary vulcanization, vulcanization time 130min, and curing temperature is 190 DEG C, then secondary
Vulcanization, vulcanization time 30min, curing temperature are 145 DEG C of demouldings, are put into vacuum mold and are overlaid on nonwoven surface, spare；
2) Medical silicone gels are stirred evenly, is scratched, is coated in the silicon rubber film layer of step 1), coating layer thickness is
1.8mm is put into vacuum mold, solidification, and solidification temperature is 120 DEG C, curing time 12min；
3) centrifugation membrane pressure is overlying on to the surface of silicon gel layer obtained by step 2), is cut to the rectangle of 50mm × 200mm；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
2. detection method
2.1 elongation rate of tensile failure Example 1-6 and comparative example each 5, are cut into the strip of 25mm × 160mm, with full intelligence
It can the test of computer peeling strength test machine.
2.2 tensile strength Example 1-6 and comparative example each 5, are cut into the strip of 25mm × 160mm, with full intelligence
The test of computer peeling strength test machine.
2.3 first property test Example 1-6 and comparative example each 5, and according to GB/T 4852-2002, " pressure-sensitive tape is just viscous
Property test method (rolling ball method) " in [7 inclined-plane method A rolling ball method] prescriptive procedure detected with No. 6 steel balls.
3 testing results, are shown in Table 1.
1 performance indicator of table
Conclusion: embodiment 1-6 and comparative example performance indicator meet the requirements, and wherein proportional tensile strength is weaker,
It is easier to break, and the tensile strength of 1-6 of the embodiment of the present invention is big, good toughness, time during Reusability is longer.
Typical case 1
Lee, female 25 years old, cause scar after finishing caesarean operation, through the medical scar plaster pair with drug containing of the present invention
It is treated at scar, does not cause ill symptoms, using 24 hours, scar softened smoothly, and after 3 days, scar is obviously improved,
After 5 days, the exquisiteness that skin becomes is smooth naturally, and without recurrence.
Typical case 2
Zhang, male, 30 years old, arm fracture second operation after cause scar, through the medical scar plaster with drug containing of the present invention
To treating at scar, using 24 hours, scar plaster no edge curl phenomenon, epidermis was reduced without whiting, scar red.10 days
Scar hyperplasia disappears afterwards, and fold tightening phenomenon occurs in skin, and the later period pays a return visit without recurrence.
Typical case 3
Wu, male, 40 years old, thyroid operation caused scar, through with the medical scar plaster of drug containing of the present invention to scar at
It is treated, no significant discomfort sense, after 4 days, raised scar disappears.
Typical case 4
Liu, male, 45 years old, III degree of right arm was scalded, through with the medical scar plaster of drug containing of the present invention to being controlled at scar
It treats, rear projection scar smooths substantially within 10 days.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of medical scar plaster of drug containing, which is characterized in that including being centrifuged film (1), drug containing silicon gel layer (2), silicon rubber
Adhesive film (3), non-woven fabrics (4), using the side close to the surface of a wound as internal layer, the centrifugation film (1), drug containing silicon gel layer (2), silicon
Rubber film layer (3), non-woven fabrics (4) are successively bonded from inside to outside；
Or, the centrifugation film (1), drug containing silicon gel layer (2), non-woven fabrics (4), silicon rubber film layer (3) are successively glued from the inside to the outside
It connects；
The drug containing silicon gel layer and silicon rubber film layer along its length on section be arc.
2. a kind of medical scar plaster of drug containing according to claim 1, which is characterized in that table in the silicon rubber film layer
Face is evenly equipped with micropore, and aperture is 1.5 ± 0.5mm.
3. a kind of medical scar plaster of drug containing according to claim 1, which is characterized in that the centrifugation film (1), drug containing
When object silicon gel layer (2), non-woven fabrics (4), silicon rubber film layer (3) are successively bonded from the inside to the outside, the silicon rubber film layer is remote
Netted anti-sticking line is equipped with from the side of the surface of a wound.
4. a kind of medical scar plaster of drug containing according to claim 1, which is characterized in that medical each layer of scar plaster
Thickness is respectively as follows: centrifugation film 0.07-0.1mm, drug containing silicon gel layer 0.2-2.0mm, silicon rubber film layer 0.07-0.12mm, nothing
Woven fabric 0.01-0.15mm.
5. a kind of medical scar plaster of drug containing according to claim 1, which is characterized in that the drug containing silicon gel layer
(2) drug ingedient in are as follows: every m2Medical scar plaster 0.16g containing triamcinolone acetonide acetate, the vitamin B of drug containing11.5g。
6. a kind of preparation method of the medical scar plaster of drug containing, which comprises the following steps:
1) non-woven fabrics is covered in vacuum arcuate die, medical grade silicon rubber roller coating is prepared into silicone rubber membrane on Teflon film cloth
Layer carries out primary vulcanization and post-cure, and demoulding is put into vacuum arcuate die and is overlaid on nonwoven surface, spare；
2) drug containing Silica hydrogel is coated in the silicon rubber film layer of step 1), is formed drug containing silicon gel layer (2), is put into vacuum
In arcuate die, solidification；
3) centrifugation membrane pressure is overlying on to the surface of the drug containing silicon gel layer of step 2), is cut to required specification area；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
Or, 1) medical grade silicon rubber roller coating is prepared silicon rubber film layer on Teflon film cloth, primary vulcanization and secondary sulphur are carried out
Change, demoulding, silicone rubber membrane lamination is overlayed in vacuum arcuate die, non-woven fabrics is put into vacuum arcuate die and is overlaid on silicon rubber
Glue film layer surface, it is spare；
2) drug containing Silica hydrogel is coated on the non-woven fabrics of step 1), is formed drug containing silicon gel layer (2), is put into vacuum arc
In mold, solidification；
3) centrifugation membrane pressure is overlying on to the surface of the drug containing silicon gel layer of step 2), is cut to required specification area；
4) sterilization is carried out after product packaging, product carries out steriling test, and it is qualified up to this product to examine.
7. a kind of preparation method of the medical scar plaster of drug containing according to claim 6, which is characterized in that the step
1) in, the primary vulcanization time is 100-130min, and curing temperature is 160-190 DEG C；The time of post-cure is 15-30min,
Curing temperature is 140-150 DEG C.
8. a kind of preparation method of the medical scar plaster of drug containing according to claim 6, which is characterized in that the step
2) in, the preparation method of drug containing silicon gel layer (2) includes: that isomery dodecane and silicone oil are added into drug, carries out vacuum cream
Change, emulsification times 25-30min, emulsifying temperature is 25 ± 2 DEG C, is stirred evenly afterwards with Medical silicone gels, mixing time 25-
30min, whipping temp are 25 ± 2 DEG C to get drug containing Silica hydrogel, and drug containing Silica hydrogel is coated on to the silicone rubber membrane of step 1)
Drug containing silicon gel layer is formed on layer or non-woven fabrics.
9. a kind of preparation method of the medical scar plaster of drug containing according to claim 6, which is characterized in that the step
2) in, every m2The drug containing silicon gel layer of the medical scar plaster of drug containing contains Silica hydrogel 500g, isomery dodecane 200g, silicone oil
150g。
10. a kind of preparation method of the medical scar plaster of drug containing according to claim 6, which is characterized in that the step
It is rapid 2) in, solidification temperature be 80-120 DEG C, curing time 8-12min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811308359.XA CN109125913A (en) | 2018-11-05 | 2018-11-05 | A kind of medical scar plaster of drug containing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811308359.XA CN109125913A (en) | 2018-11-05 | 2018-11-05 | A kind of medical scar plaster of drug containing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109125913A true CN109125913A (en) | 2019-01-04 |
Family
ID=64807802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811308359.XA Pending CN109125913A (en) | 2018-11-05 | 2018-11-05 | A kind of medical scar plaster of drug containing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109125913A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110430A (en) * | 2019-12-31 | 2020-05-08 | 帝斯博（常州）医疗用品股份有限公司 | Self-adhesive type male urethral catheterization sleeve and manufacturing method thereof |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1119204A (en) * | 1997-07-02 | 1999-01-26 | Sekisui Chem Co Ltd | Waterproof first aid sticking plaster |
| CN1272055A (en) * | 1997-09-30 | 2000-11-01 | 科洛普拉斯特公司 | Dressing article |
| US20020156410A1 (en) * | 2001-04-19 | 2002-10-24 | Roger Lawry | Scar tissue treatment bandage and method |
| US20050095276A1 (en) * | 2002-03-22 | 2005-05-05 | Beiersdorf Ag | Scar-reducing plaster |
| WO2005097021A1 (en) * | 2004-03-31 | 2005-10-20 | Schering Ag | Medical plaster for application on the skin |
| CN2780196Y (en) * | 2005-04-19 | 2006-05-17 | 曾维桥 | Plaster for removing scar |
| CN102742983A (en) * | 2012-07-19 | 2012-10-24 | 力其国际有限公司 | Rubber layer mold pressing product and manufacturing method thereof |
| CN202933243U (en) * | 2012-09-05 | 2013-05-15 | 郭红梅 | Patch |
| CN105055377A (en) * | 2015-08-13 | 2015-11-18 | 蚌埠崇迪生物科技有限公司 | Scar sheet and preparation technology thereof |
| CN204815350U (en) * | 2015-07-15 | 2015-12-02 | 济南市妇幼保健院 | Magnesium sulfate piece of applying ointment or plaster |
| CN105288701A (en) * | 2015-11-27 | 2016-02-03 | 上海诺月医疗科技有限公司 | Silica gel dressing film and production method thereof |
| CN106421688A (en) * | 2016-09-18 | 2017-02-22 | 厦门市香妃美业化妆品有限公司 | Miao medicine fire moxibustion hot compress energy patch and application method thereof |
| CN107099142A (en) * | 2017-04-14 | 2017-08-29 | 佛山市秸和科技有限公司 | A kind of preparation method of silicone rubber membrane |
-
2018
- 2018-11-05 CN CN201811308359.XA patent/CN109125913A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1119204A (en) * | 1997-07-02 | 1999-01-26 | Sekisui Chem Co Ltd | Waterproof first aid sticking plaster |
| CN1272055A (en) * | 1997-09-30 | 2000-11-01 | 科洛普拉斯特公司 | Dressing article |
| US20020156410A1 (en) * | 2001-04-19 | 2002-10-24 | Roger Lawry | Scar tissue treatment bandage and method |
| US20050095276A1 (en) * | 2002-03-22 | 2005-05-05 | Beiersdorf Ag | Scar-reducing plaster |
| WO2005097021A1 (en) * | 2004-03-31 | 2005-10-20 | Schering Ag | Medical plaster for application on the skin |
| CN2780196Y (en) * | 2005-04-19 | 2006-05-17 | 曾维桥 | Plaster for removing scar |
| CN102742983A (en) * | 2012-07-19 | 2012-10-24 | 力其国际有限公司 | Rubber layer mold pressing product and manufacturing method thereof |
| CN202933243U (en) * | 2012-09-05 | 2013-05-15 | 郭红梅 | Patch |
| CN204815350U (en) * | 2015-07-15 | 2015-12-02 | 济南市妇幼保健院 | Magnesium sulfate piece of applying ointment or plaster |
| CN105055377A (en) * | 2015-08-13 | 2015-11-18 | 蚌埠崇迪生物科技有限公司 | Scar sheet and preparation technology thereof |
| CN105288701A (en) * | 2015-11-27 | 2016-02-03 | 上海诺月医疗科技有限公司 | Silica gel dressing film and production method thereof |
| CN106421688A (en) * | 2016-09-18 | 2017-02-22 | 厦门市香妃美业化妆品有限公司 | Miao medicine fire moxibustion hot compress energy patch and application method thereof |
| CN107099142A (en) * | 2017-04-14 | 2017-08-29 | 佛山市秸和科技有限公司 | A kind of preparation method of silicone rubber membrane |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110430A (en) * | 2019-12-31 | 2020-05-08 | 帝斯博（常州）医疗用品股份有限公司 | Self-adhesive type male urethral catheterization sleeve and manufacturing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6318169B2 (en) | Wound dressing with adhesive rim | |
| US3328259A (en) | Dressing for a wound containing a hemostatic agent and method of treating a wound | |
| EP2158885B1 (en) | Adhesive Patch | |
| RU2711863C2 (en) | Two-component wound dressing system | |
| JP6953568B2 (en) | Wound bandage assembly | |
| EP3453367A1 (en) | Adhesive film bandage for medical compression | |
| JPH07502913A (en) | bandage | |
| US20150320606A1 (en) | Facial Patch | |
| CN102293697A (en) | Preparation technique and application of eye protection plaster | |
| JPS5957654A (en) | Low stickiness wound dressing | |
| CN109125913A (en) | A kind of medical scar plaster of drug containing and preparation method thereof | |
| JPH06501857A (en) | double layer dressing | |
| JP5810418B2 (en) | Adhesive material | |
| US20200368084A1 (en) | First aid medical treatment apparatus and method | |
| US10912739B2 (en) | Hydrocolloid-based skin treatment | |
| WO1989003765A1 (en) | Waterproof skin covering | |
| CN205359798U (en) | Woundplast that contains oxidized regenerated cellulose | |
| US20200315857A1 (en) | Pasting structure | |
| CN216168261U (en) | Medical hydrogel patch | |
| CN211096206U (en) | Medicine invasive biological film | |
| CN110403920B (en) | Disposable medical hydrogel eye patch | |
| CN210698271U (en) | Traditional Chinese medicine patch for dermatology | |
| CN210144862U (en) | Adhesive bandage containing Aloe and tea | |
| CN206391083U (en) | A kind of hydrogel bandage | |
| EP3939555A1 (en) | Adhesive eyelid closure article |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200108 Address after: 510000 zone B, west of the fourth floor of the main workshop, No. 253, Kaifa Avenue, Guangzhou Economic and Technological Development Zone, Guangdong Province Applicant after: Guangzhou city Cozi medical instrument limited company Address before: 510730 Guangzhou Economic and Technological Development Zone, Guangdong Province Applicant before: Wang Yunpeng |
|
| TA01 | Transfer of patent application right |