CN109125179B - Antioxidant soothing moisturizing cream composition and preparation method thereof - Google Patents
Antioxidant soothing moisturizing cream composition and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses an antioxidant soothing moisturizing cream composition and a preparation method thereof. According to the invention, specific natural trehalose substances and traditional Chinese medicine extracts are selected for compounding, and specific dosage proportion, specific preparation process and specific parameters are selected, so that the antioxidant soothing moisturizing cream composition with high stability is obtained, and a synergistic effect is obtained in the aspect of antioxidant effect.
Description
Technical Field
The invention belongs to the technical field of daily cosmetics, and particularly relates to an antioxidant soothing moisturizing cream composition and a preparation method thereof.
Background
The sea area of China is vast, the seaweed resources are extremely rich, the yields of kelp and undaria pinnatifida are the first world, and the yield of laver is second to Japan. Other seaweed such as undaria pinnatifida and enteromorpha is also quite abundant in resources. The Sargassum is rich in active substances such as polysaccharides, polyphenols, terpenoids, and polyunsaturated fatty acids. The algal polysaccharide has various biological functions, such as moisture retention, antioxidant activity, antibacterial activity, etc. At present, marine economic algae are widely applied to food industry, medicine industry, energy and other chemical resources at home and abroad. However, the prior seaweed processing technology in China is relatively laggard, the product is single, the quality is lower, and rich active substances contained in seaweed plants are far from being fully developed. Therefore, the method has good development prospect for the research of the deep processing direction of the seaweed and is expected to bring greater economic benefit.
With the continuous development of social economy, more and more people choose to use skin care products, so that the cosmetics on the market emerge like bamboo shoots in spring after rain. Nowadays, in daily life of people, there are many factors causing oxidative aging of skin cells, ultraviolet rays, mobile phones, air pollution, and the like. These factors all increase free radicals in the skin, which causes many skin problems, such as lack of water, dullness, premature senility, etc., and the use of antioxidant skin care products is very important. At present, functional skin care products mainly comprise two types of products: chemical products and biological products. Due to the addition of chemically synthesized or chemically extracted substances in chemical products, certain potential safety hazards exist and the due safety requirements cannot be met.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an antioxidant soothing moisturizing cream composition.
The invention also aims to provide a preparation method of the antioxidant soothing moisturizing cream composition.
The technical scheme of the invention is as follows:
an antioxidant soothing moisturizing cream composition comprises raw materials of antioxidant active components and conventional cosmetic components, wherein the antioxidant active components comprise agar oligosaccharide extract, medium-viscosity sodium alginate and radix astragali extract; the conventional components of the cosmetics comprise glyceryl monostearate, dimethyl silicone oil, anhydrous lanolin, liquid paraffin, stearic acid, cetyl alcohol, glycerol, propylene glycol, tween-60, triethanolamine, ethylparaben, azone, essence and deionized water;
the preparation method of the agar oligosaccharide extracting solution comprises the following steps: heating and dissolving agar in a Tris-HCl buffer solution with the pH value of 7.0-9.0, cooling, adding agarase, incubating at 35-55 ℃ and 250r/min at 150-3.5: 1 for 3-20h, boiling for 4-6min, cooling and standing to precipitate the unreacted agar and polysaccharide to the bottom, wherein the final concentration of the agarase is 0.2-0.4%; centrifuging at 7000 plus 9000r/min for 8-11min, taking supernatant, performing rotary evaporation concentration on the supernatant, dialyzing to remove small molecular salt, diluting to the concentration before dialysis, adding activated carbon, performing full adsorption at room temperature, performing suction filtration, adding 10-100% ethanol into the activated carbon obtained by suction filtration, stirring, desorbing, performing suction filtration, and concentrating filtrate to obtain the agar oligosaccharide extracting solution;
the preparation method of the sodium alginate with moderate viscosity comprises the following steps: weighing a proper amount of seaweed, cleaning, drying and crushing the seaweed, adding 2-4 times of ethanol by weight for reflux extraction, adding 8-12 times of hot water by weight for reflux extraction of residues for 2 hours, filtering, concentrating filtrate, adding 2-4 times of ethanol by weight, standing for 8-12 hours, filtering to obtain precipitate and dried to obtain the medium-viscosity seaweed polysaccharide;
the preparation method of the radix astragali extract comprises the following steps: weighing a proper amount of radix astragali, cleaning, drying and crushing, percolating with 10-13 times of ethanol water solution to obtain a percolate and a percolation residue, adding 2-3 times of ethanol water solution into the percolation residue, soaking for 6-12h, performing ultrasonic extraction for 30-60min to obtain an ultrasonic extraction solution and an ultrasonic extraction residue, combining the ultrasonic extraction solution and the percolate, filtering, and performing reduced pressure evaporation and concentration on the obtained filtrate to obtain 10-15% of the original volume to obtain the radix astragali extraction solution.
In a preferred embodiment of the invention, the raw materials comprise the following components in percentage by weight: 0.5-2.5% of agar oligosaccharide extract, 0.2-1.4% of sodium alginate, 0.5-1.5% of astragalus extract, 1.0-1.5% of glycerol monostearate, 1.0-3.0% of simethicone, 1.5-2.0% of anhydrous lanolin, 3.0-5.0% of liquid paraffin, 4.0-6.0% of stearic acid, 4.0-6.0% of cetyl alcohol, 2.0-3.0% of glycerol, 2.0-3.0% of propylene glycol, 601.5-3.0% of tween-tween, 0.1-0.5% of triethanolamine, 0.05-0.15% of ethylparaben, 0.5-1.5% of azone, a proper amount of essence and the balance of deionized water.
Further preferably, the raw materials comprise the following components in percentage by weight: 2.0% of agar oligosaccharide extracting solution, 0.2% of sodium alginate, 1.0% of astragalus extract, 1.5% of glyceryl monostearate, 3.0% of simethicone, 2.0% of anhydrous lanolin, 5.0% of liquid paraffin, 6.0% of stearic acid, 4.0% of cetyl alcohol, 3.0% of glycerol, 3.0% of propylene glycol, 601.5% of tween-tween, 0.3% of triethanolamine, 0.15% of ethylparaben, 1.0% of azone and a proper amount of essence, and the balance of deionized water.
Further preferably, the raw materials comprise the following components in percentage by weight: 2.0% of agar oligosaccharide extracting solution, 0.4% of sodium alginate, 0.5% of astragalus extract, 1.5% of glyceryl monostearate, 3.0% of simethicone, 2.0% of anhydrous lanolin, 5.0% of liquid paraffin, 6.0% of stearic acid, 4.0% of hexadecanol, 3.0% of glycerol, 3.0% of propylene glycol, 601.5% of tween-tween, 0.3% of triethanolamine, 0.15% of ethylparaben, 1.0% of azone and a proper amount of essence, and the balance of deionized water.
Further preferably, the raw materials comprise the following components in percentage by weight: 1.0% of agar oligosaccharide extracting solution, 0.4% of sodium alginate, 1.0% of astragalus extract, 1.5% of glycerol monostearate, 3.0% of simethicone, 2.0% of anhydrous lanolin, 5.0% of liquid paraffin, 6.0% of stearic acid, 4.0% of hexadecanol, 3.0% of glycerol, 3.0% of propylene glycol, 601.5% of tween-glycerol, 0.3% of triethanolamine, 0.15% of ethylparaben, 1.0% of azone and a proper amount of essence, and the balance of deionized water.
The preparation method of the antioxidant soothing moisturizing cream composition comprises the following steps:
(1) mixing glyceryl monostearate, dimethyl silicone oil, anhydrous lanolin, liquid paraffin, stearic acid, cetyl alcohol and ethylparaben, adding into a first emulsifying pot, and homogenizing at 75-85 deg.C for 20-30 min;
(2) adding glycerol, propylene glycol, Tween-60, triethanolamine, agar oligosaccharide extract, sodium alginate, radix astragali extract and deionized water into a second emulsifying pot, and homogenizing at 75-85 deg.C for 20-30 min;
(3) and (3) mixing the materials obtained in the steps (1) and (2), homogenizing and emulsifying, homogenizing at 75-85 ℃ for 10-20min, cooling to 45-55 ℃, adding azone and essence, stirring uniformly for 5-10min, and cooling to room temperature to obtain the antioxidant soothing moisturizing cream composition.
The invention has the beneficial effects that:
the antioxidant active ingredients adopted by the invention consist of AGAR OLIGOSACCHARIDE extract (AGAR OLIGOSACCHARIDE), SODIUM ALGINATE (SODIUM ALGINATE) and RADIX ASTRAGALI (RADIX ASTRAGALI) extracts, and the mass percentages of the antioxidant, soothing and moisturizing cream are as follows: the antioxidant soothing moisturizing cream composition with high stability is obtained by selecting specific natural seaweed carbohydrate substances and Chinese medicinal extracts for compounding, and selecting specific dosage proportion, specific preparation process and specific parameters, and simultaneously obtains a synergistic effect in the aspect of antioxidant efficacy.
Detailed Description
The technical solution of the present invention is further illustrated and described by the following detailed description.
Example 1 preparation of agar oligosaccharide extract:
heating and dissolving 100g of agar in a Tris-HCl buffer solution with the pH value of 8.5, mixing the agar and agarase according to the ratio of 3: 1 after the agar solution is cooled, namely adding 33g of agarase to ensure that the final concentration of the agar solution is 0.3%, respectively culturing for 12h at the temperature of 45 ℃ and at the speed of 200r/min, boiling for 5min, cooling the agar oligosaccharide extract mixture at the temperature of 4 ℃ overnight, and precipitating the unreacted agar and polysaccharide to the bottom; centrifuging at 8000r/min for 10min, collecting 500mL supernatant, rotary evaporating the supernatant, concentrating, dialyzing with dialysis bag with molecular cut-off of 200Da, and removing small molecular salt. Diluting the dialyzed agar oligosaccharide extract mixture to the concentration before dialysis, adding 0.25% of activated carbon, carrying out suction filtration after adsorbing at room temperature for 1h, adding 65% ethanol solution into the obtained activated carbon after suction filtration, stirring and desorbing for 1.5h each time, carrying out suction filtration, and concentrating the filtrate to obtain the agar oligosaccharide extract.
Preparation of sodium alginate in example 2:
weighing an appropriate amount of 200g of kelp, cleaning, drying, crushing, adding 600mL of ethanol for reflux extraction, adding 1000mL of hot water for reflux extraction of residues for 2h, filtering, concentrating the filtrate, adding 1200mL of ethanol, standing overnight, filtering, and drying the obtained precipitate to obtain the medium-viscosity algal polysaccharide.
Example 3 preparation of astragalus extract:
weighing 100g of astragalus mongholicus, cleaning, drying, crushing, percolating with 1200mL of ethanol water solution to obtain percolate and percolate residue, adding 150mL of ethanol water solution into the percolate residue, soaking for 8h, performing ultrasonic extraction for 60min to obtain ultrasonic extraction liquid and ultrasonic extraction residue, combining the ultrasonic extraction liquid and the percolate, filtering, and performing reduced pressure evaporation and concentration on the filtrate to obtain the astragalus mongholicus extract, wherein the astragalus mongholicus extract is obtained.
Example 4
An antioxidant soothing moisturizing cream composition taking natural trehalose and Chinese herbal medicine extracts as active ingredients is prepared from the following raw materials in percentage by mass:
the preparation method of the antioxidant soothing moisturizing cream composition comprises the following steps:
(1) the raw materials are divided into the following three groups:
group one: glyceryl monostearate, dimethicone, anhydrous lanolin, liquid paraffin, stearic acid, cetyl alcohol, and ethylparaben;
and a second group: glycerol, propylene glycol, tween-60, triethanolamine, the agar oligosaccharide extract prepared in example 1, the sodium alginate having a medium viscosity prepared in example 2, the astragalus extract prepared in example 3, and deionized water;
and (3) group III: azone, essence;
(2) mixing all the components of the first group, adding into a first emulsifying pot, and homogenizing at 75-85 deg.C for 20-30 min;
(3) mixing all the components of the second group, adding into the first emulsifying pot, and homogenizing at 75-85 deg.C for 10-20 min;
(4) mixing the liquids of steps (1) and (2) with each other, homogenizing and emulsifying for 10-20min, cooling to 45-55 deg.C after emulsifying, adding all the three components, stirring uniformly for 5-10min, and cooling to room temperature to obtain the final product.
Example 5:
an antioxidant soothing moisturizing cream taking natural trehalose and Chinese medicinal extracts as active ingredients is prepared from the following raw materials in percentage by mass:
the antioxidant soothing moisturizer composition of this example was prepared in the same manner as in example 4.
Example 6:
an antioxidant soothing moisturizing cream taking natural trehalose and Chinese medicinal extracts as active ingredients is prepared from the following raw materials in percentage by mass:
the antioxidant soothing moisturizer composition of this example was prepared in the same manner as in example 4.
Comparative example 1
Heating and dissolving 100g of agar in a Tris-HCl buffer solution with the pH value of 8.5, mixing the agar and agarase according to the ratio of 3: 1 after the agar solution is cooled, namely adding 33g of agarase to ensure that the final concentration of the agar solution is 0.3%, respectively culturing for 6 hours at the temperature of 45 ℃ and at the speed of 200r/min, boiling for 5 minutes, cooling the agar oligosaccharide extract mixture at the temperature of 4 ℃ overnight, and precipitating the unreacted agar and polysaccharide to the bottom; centrifuging at 8000r/min for 10min, collecting 500mL supernatant, rotary evaporating the supernatant, concentrating, dialyzing with dialysis bag with molecular cut-off of 200Da, and removing small molecular salt. Diluting the dialyzed agar oligosaccharide extract mixture to the concentration before dialysis, adding 0.25% of activated carbon, carrying out suction filtration after adsorbing at room temperature for 1h, adding 50% ethanol solution into the obtained activated carbon after suction filtration, stirring and desorbing for 1.5h each time, carrying out suction filtration, and concentrating the filtrate to obtain agar oligosaccharide extract.
Comparative example 2
Weighing 200g of kelp, cleaning, drying, crushing, adding 400mL of ethanol for reflux extraction, adding 800mL of hot water for reflux extraction of residues for 2h, filtering, concentrating the filtrate, adding 1000mL of ethanol, standing overnight, filtering, and drying the obtained precipitate to obtain the algal polysaccharide.
Comparative example 3
Weighing 100g of astragalus mongholicus, cleaning, drying, crushing, percolating with 1000mL of ethanol water solution to obtain percolate and percolate residue, adding 100mL of ethanol water solution into the percolate residue, soaking for 6h, performing ultrasonic extraction for 40min to obtain an ultrasonic extraction solution and ultrasonic extraction residue, combining the ultrasonic extraction solution and the percolate, filtering, and performing reduced pressure evaporation and concentration on the filtrate to obtain 10% of the original volume to obtain the astragalus mongholicus extraction solution.
Comparative example 4
An antioxidant soothing moisturizing cream composition is prepared from the following raw materials in percentage by mass:
the comparative antioxidant soothing moisturizer composition was prepared as in example 4.
Comparative example 5
An antioxidant soothing moisturizing cream composition is prepared from the following raw materials in percentage by mass:
the comparative antioxidant soothing moisturizer composition was prepared as in example 4.
Comparative example 6
An antioxidant soothing moisturizing cream composition is prepared from the following raw materials in percentage by mass:
the comparative antioxidant soothing moisturizer composition was prepared as in example 4.
Example 7
In order to verify the stability of the antioxidant soothing moisturizing cream compositions prepared in examples 4-6 and comparative examples 4-6 during storage and use, the moisturizing cream compositions were subjected to strict tests on high-temperature and low-temperature storage stability according to GB/T29665-.
Test 1: centrifuging at 3000r min-1 for 30min, and observing whether the moisturizing cream composition is layered;
and (3) testing 2: continuously keeping the temperature at 48 ℃ for 20 days, then recovering the room temperature and keeping the room temperature for more than 8 hours, and observing whether the moisturizing cream composition has the phenomenon of layering and separating out solids or other non-uniform phenomena;
and (3) testing: continuously freezing at-25 deg.C for 20d, recovering room temperature, maintaining for more than 8h, and observing whether the moisturizing cream composition has the phenomenon of layering and separating out solid or other inhomogeneities;
and (4) testing: and (3) alternately circulating the cold and the heat for 24 hours at 48 ℃ and 25 ℃ below zero for 20 days, then recovering the room temperature and keeping the room temperature for more than 8 hours, and observing whether the moisturizing cream composition has the phenomenon of layering and separating out solids or other non-uniform phenomena.
In the above test, if there is no delamination of solids or other inhomogeneities in the moisturizer composition, the stability test is passed, otherwise the stability test is failed.
Tests prove that the moisturizing cream compositions of examples 4-6 pass the above tests, and the antioxidant soothing moisturizing cream compositions of the invention have stable performance and high stability during storage and use. The moisturizing cream compositions of comparative examples 4-6 failed the above tests, which shows that the composition of the present invention obtained unexpected effects in terms of system stability after using the agar oligosaccharide extract prepared in example 1, the sodium alginate having a medium viscosity prepared in example 2, and the astragalus extract prepared in example 3.
Example 8 detection of antioxidant Effect of the antioxidant soothing moisturizer composition of the invention
The moisturizing cream compositions of examples 4 to 6 and comparative examples 4 to 6 were prepared into sample solutions of the same concentration, respectively, and the following experiments were performed.
Reagent: 1, 1-Diphenyl-2-trinitrophenylhydrazine (DPPH. cndot.) is supplied by Sigma;
absolute ethanol (AR) ferrous sulfate H2O2Salicylic acid is provided by Jiangtian chemical technology, Inc. in Tianjin;
UV1601 ultraviolet spectrophotometer is provided by shimadzu corporation, japan.
1. Ability to scavenge free radicals (DPPH.)
DPPH is dark purple at 517nm and has strong absorption, and due to the existence of a free radical scavenger, the lone electron pair of DPPH is paired (shown as formula 1), so that the color of the solution is lightened, the absorbance at the maximum absorption wavelength is reduced, and the lightening degree of the color is in a stoichiometric relation with the number of paired electrons. Therefore, the radical scavenging can be judged by measuring the absorbance at a wavelength of 517 nm.
Formula 1: AH + DPPH → DPPH-H + A
To the tube was added 2mL of a 95% ethanol solution containing 0.15mmol/L DPPH and 2mL of an antioxidant, and after mixing and shaking, the mixture was left in the dark at room temperature for 30 min. The absorbance of the reaction solution at 517nm was measured and recorded as Ai. Distilled water was measured instead of the antioxidant and was designated as Ac. Ethanol was measured instead of DPPH solution and is reported as Aj.
The formula for the clearance R value is:
the results are shown in Table 1
TABLE 1
| Sample solution | For DPPH.Rate of removal (%) |
| Example 4 | 92.24 |
| Example 5 | 87.10 |
| Example 6 | 89.37 |
| Comparative example 4 | 77.73 |
| Comparative example 5 | 29.62 |
| Comparative example 6 | 86.43 |
As can be seen from the results in table 1, the moisturizing cream compositions (moisturizing cream compositions of examples 4 to 6) containing the agar-oligosaccharide extract prepared in example 1, the sodium alginate mucor prepared in example 2, and the astragalus extract prepared in example 3 together have significantly higher DPPH removal capability than the moisturizing cream compositions (moisturizing cream compositions of comparative examples 4 to 6) containing the agar-oligosaccharide extract prepared in example 1 alone, the sodium alginate mucor prepared in example 2 alone, and the astragalus extract prepared in example 3 alone, which indicates that the agar-oligosaccharide extract prepared in example 1, the sodium alginate mucor prepared in example 2, and the astragalus extract prepared in example 3 are used together, and have synergistic effect in terms of oxidation resistance.
2. Ability to scavenge hydroxyl radicals
OH clearance determination method: 9mmol/L salicylic acid-ethanol 1mL9mmol/mLFeSO are added into the reaction system in turn41mL and 1mL of antioxidant, and finally 8.8mmol/LH2O2The reaction was started at 1 mL. Immediately transferring the mixture into a 37 ℃ water bath to perform constant-temperature reaction for 30min after the reaction is started, and measuring the light absorption values A of different antioxidants at 510nmxUsing 9mmol/L salicylic acid-ethanol 1mL9mmol/mLFeSO41mL of sample, 1mL of sample and 1mL of double distilled water as background absorption value A of samplex0。
Blank control absorbance is A0。
And (3) calculating the clearance rate:
the results are shown in Table 2
TABLE 2
As can be seen from the results in table 2, the moisturizing cream compositions (moisturizing cream compositions of examples 4 to 6) containing the agar-oligosaccharide extract prepared in example 1, the sodium alginate mucor prepared in example 2, and the astragalus extract prepared in example 3 together have significantly higher removal capability for OH than the moisturizing cream compositions (moisturizing cream compositions of comparative examples 4 to 6) containing the agar-oligosaccharide extract prepared in example 1 alone, the sodium alginate mucor prepared in example 2 alone, and the astragalus extract prepared in example 3 alone, which indicates that the agar-oligosaccharide extract prepared in example 1, the sodium alginate mucor prepared in example 2, and the astragalus extract prepared in example 3 are used together, and have synergistic effect in oxidation resistance.
The above description is only a preferred embodiment of the present invention, and therefore should not be taken as limiting the scope of the invention, which is defined by the appended claims.
Claims (6)
1. An antioxidant soothing moisturizer composition is characterized in that: the raw materials of the cosmetic comprise antioxidant active components and conventional cosmetic components, wherein the antioxidant active components comprise agar oligosaccharide extracting solution, medium-viscosity sodium alginate and astragalus extract; the conventional components of the cosmetics comprise glyceryl monostearate, dimethyl silicone oil, anhydrous lanolin, liquid paraffin, stearic acid, cetyl alcohol, glycerol, propylene glycol, tween-60, triethanolamine, ethylparaben, azone, essence and deionized water;
the preparation method of the agar oligosaccharide extracting solution comprises the following steps: heating and dissolving agar in a Tris-HCl buffer solution with the pH value of 7.0-9.0, cooling, adding agarase, incubating at 35-55 ℃ and 250r/min at 150-3.5: 1 for 3-20h, boiling for 4-6min, cooling and standing to precipitate the unreacted agar and polysaccharide to the bottom, wherein the final concentration of the agarase is 0.2-0.4%; centrifuging at 7000 plus 9000r/min for 8-11min, taking supernatant, performing rotary evaporation concentration on the supernatant, dialyzing to remove small molecular salt, diluting to the concentration before dialysis, adding activated carbon, performing full adsorption at room temperature, performing suction filtration, adding 10-100% ethanol into the activated carbon obtained by suction filtration, stirring, desorbing, performing suction filtration, and concentrating filtrate to obtain the agar oligosaccharide extracting solution;
the preparation method of the sodium alginate with moderate viscosity comprises the following steps: weighing a proper amount of seaweed, cleaning, drying and crushing the seaweed, adding 2-4 times of ethanol by weight for reflux extraction, adding 8-12 times of hot water by weight for reflux extraction of residues for 2 hours, filtering, concentrating filtrate, adding 2-4 times of ethanol by weight, standing for 8-12 hours, filtering to obtain precipitate and dried to obtain the medium-viscosity seaweed polysaccharide;
the preparation method of the radix astragali extract comprises the following steps: weighing a proper amount of radix astragali, cleaning, drying and crushing, percolating with 10-13 times of ethanol water solution to obtain a percolate and a percolation residue, adding 2-3 times of ethanol water solution into the percolation residue, soaking for 6-12h, performing ultrasonic extraction for 30-60min to obtain an ultrasonic extraction solution and an ultrasonic extraction residue, combining the ultrasonic extraction solution and the percolate, filtering, and performing reduced pressure evaporation and concentration on the obtained filtrate to obtain 10-15% of the original volume to obtain the radix astragali extraction solution.
2. The antioxidant soothing moisturizer composition of claim 1, wherein: the raw materials of the material comprise the following components in percentage by weight: 0.5-2.5% of agar oligosaccharide extract, 0.2-1.4% of sodium alginate, 0.5-1.5% of astragalus extract, 1.0-1.5% of glycerol monostearate, 1.0-3.0% of simethicone, 1.5-2.0% of anhydrous lanolin, 3.0-5.0% of liquid paraffin, 4.0-6.0% of stearic acid, 4.0-6.0% of cetyl alcohol, 2.0-3.0% of glycerol, 2.0-3.0% of propylene glycol, 601.5-3.0% of tween-tween, 0.1-0.5% of triethanolamine, 0.05-0.15% of ethylparaben, 0.5-1.5% of azone, a proper amount of essence and the balance of deionized water.
3. The antioxidant soothing moisturizer composition of claim 2, wherein: the raw materials of the material comprise the following components in percentage by weight: 2.0% of agar oligosaccharide extracting solution, 0.2% of sodium alginate, 1.0% of astragalus extract, 1.5% of glyceryl monostearate, 3.0% of simethicone, 2.0% of anhydrous lanolin, 5.0% of liquid paraffin, 6.0% of stearic acid, 4.0% of cetyl alcohol, 3.0% of glycerol, 3.0% of propylene glycol, 601.5% of tween-tween, 0.3% of triethanolamine, 0.15% of ethylparaben, 1.0% of azone and a proper amount of essence, and the balance of deionized water.
4. The antioxidant soothing moisturizer composition of claim 2, wherein: the raw materials of the material comprise the following components in percentage by weight: 2.0% of agar oligosaccharide extracting solution, 0.4% of sodium alginate, 0.5% of astragalus extract, 1.5% of glyceryl monostearate, 3.0% of simethicone, 2.0% of anhydrous lanolin, 5.0% of liquid paraffin, 6.0% of stearic acid, 4.0% of hexadecanol, 3.0% of glycerol, 3.0% of propylene glycol, 601.5% of tween-tween, 0.3% of triethanolamine, 0.15% of ethylparaben, 1.0% of azone and a proper amount of essence, and the balance of deionized water.
5. The antioxidant soothing moisturizer composition of claim 2, wherein: the raw materials of the material comprise the following components in percentage by weight: 1.0% of agar oligosaccharide extracting solution, 0.4% of sodium alginate, 1.0% of astragalus extract, 1.5% of glycerol monostearate, 3.0% of simethicone, 2.0% of anhydrous lanolin, 5.0% of liquid paraffin, 6.0% of stearic acid, 4.0% of hexadecanol, 3.0% of glycerol, 3.0% of propylene glycol, 601.5% of tween-glycerol, 0.3% of triethanolamine, 0.15% of ethylparaben, 1.0% of azone and a proper amount of essence, and the balance of deionized water.
6. A method of preparing the antioxidant soothing moisturizer composition of any of claims 1 to 5, wherein the method comprises the steps of: the method comprises the following steps:
(1) mixing glyceryl monostearate, dimethyl silicone oil, anhydrous lanolin, liquid paraffin, stearic acid, cetyl alcohol and ethylparaben, adding into a first emulsifying pot, and homogenizing at 75-85 deg.C for 20-30 min;
(2) adding glycerol, propylene glycol, Tween-60, triethanolamine, agar oligosaccharide extract, sodium alginate, radix astragali extract and deionized water into a second emulsifying pot, and homogenizing at 75-85 deg.C for 20-30 min;
(3) and (3) mixing the materials obtained in the steps (1) and (2), homogenizing and emulsifying, homogenizing at 75-85 ℃ for 10-20min, cooling to 45-55 ℃, adding azone and essence, stirring uniformly for 5-10min, and cooling to room temperature to obtain the antioxidant soothing moisturizing cream composition.
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