CN109116568A - A kind of VR glasses - Google Patents
A kind of VR glasses Download PDFInfo
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- CN109116568A CN109116568A CN201811174372.0A CN201811174372A CN109116568A CN 109116568 A CN109116568 A CN 109116568A CN 201811174372 A CN201811174372 A CN 201811174372A CN 109116568 A CN109116568 A CN 109116568A
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- glasses
- antimicrobial peptide
- pro
- antimicrobial
- bacterium
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- 229910052737 gold Inorganic materials 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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- 239000002609 medium Substances 0.000 description 1
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- HODRFAVLXIFVTR-RKDXNWHRSA-N tevenel Chemical compound NS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)C=C1 HODRFAVLXIFVTR-RKDXNWHRSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/017—Head mounted
- G02B27/0176—Head mounted characterised by mechanical features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/017—Head mounted
- G02B2027/0178—Eyeglass type
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of VR glasses, include the eyeshade shell for wearing；The eyeshade shell is human body face curved-surface structure, and surface is coated with antimicrobial polypeptide, can be used in killing eye and face's common pathogen.Antimicrobial peptide sparges and forms thin film in a few minutes after VR glasses, not only acts as direct protective effect to glasses, kills bacterium rapidly, prevents the infection of glasses bacterium, and the film to skin with good compatibility and gas permeability；The spray film forming agent contains moisturizer ingredient, can absorb moisture, plays preferable moisture-keeping function.In addition antimicrobial peptide bacteriostatic activity is high, low in cost, can promote the use of on a large scale, with great application prospect and important social value value.
Description
Technical field
The present invention relates to vision instrument field, in particular to a kind of VR glasses.
Background technique
VR glasses, that is, VR aobvious, virtual reality head-mounted display apparatus.It is to utilize head-mounted display apparatus by people that VR aobvious
Extraneous vision, the sense of hearing are closed, guidance user generates a kind of feeling in virtual environment.Its displaying principle is left and right
Paropion curtain is shown respectively generates three-dimensional sense after the image of right and left eyes, human eye obtain this discrepant information of band in brain.
In recent years as intelligence wears the fast development of equipment, VR virtual reality technology obtains great technological break-through,
Various VR virtual reality devices have quickly pushed market to, obtain huge success, but the following equipment safety is defended
Raw problem becomes a big technical problem of puzzlement producer.Since VR glasses generally in movie theatre or use frequent place by not solid
Fixed different crowd is worn daily, causes to have remained a large amount of pathogenic bacteria above VR glasses, especially some eye disease or face
After portion's dermatosis patient use, the risk of cross-infection, therefore apparatus sanitation safety may be brought to subsequent use person
Become a big bottleneck of VR virtual reality technology development.
Antimicrobial peptide (AMP) is one group of relatively newly discovered antimicrobial with new role mode.AMP is extensive
It is distributed in animal, plant and microorganism and belongs to most ancient host defense factor.Most of this kind of peptide is in natural feelings
It is cationic and amphiphilic under condition；The characteristic allows the membrane interaction with negatively charged bacterium or fungi.This kind of peptide
Magnitude range is from 6-7 amino acid to 60 amino acid.500 kinds or more different AMP have been isolated so far.Based on knot
Structure or M acid composition can divide them into several classes.Simplest structure is small helical peptides.Other AMP fold to form lamella knot
Structure, and the other tertiary structure for forming rigid disulphide bridges connection again.
AMP be usually kill microorganism and act on it is extremely fast.In general, microorganism is killed in minutes.They
By interfering the film function of target biology to work.Have shown that there are several different mechanism of action, but for most of
AMP, total result are membranolysis and cell cracking.
But presently, there are AMP also have a technical obstacle, i.e., can not specificity be directed to face and skin disease
Bacterium, this there is no corresponding research, therefore, develops a kind of preferable AMP of effect in the prior art, before having extremely strong application
Scape.
Summary of the invention
One of technical solution of the invention provides a kind of with killing the antimicrobial of eye disease germ and face germ
Peptide, the sequence of the peptide are as follows:
AMP-1:MCCPTTHHTNHVMAGWQIQRWMHT (SEQ ID NO:1)；
AMP-2:PGCYYIDHPPPFLDPFSSLTFCQEVNV (SEQ ID NO:2)；
AMP-3:NHRSPTWPHYDLASQLPCDRCQWRENP (SEQ ID NO:3)；
AMP-4:AVSAIPWNAAWATPMHVTYKPRGHPE (SEQ ID NO:4)；
AMP-5:IHEWHIWMGIPSWVPWQWPQHHHELVPM (SEQ ID NO:5)；
AMP-6:IHGRRFPMDHRIDHRYVSKTLISAPL (SEQ ID NO:6)；
AMP-7:ASRETPDSPCRSKKIMTSMRYRAWP (SEQ ID NO:7)；
AMP-8:WALMHKSQWSWFIVPHCIHHLDCASIP (SEQ ID NO:8).
The pathogen that wherein antimicrobial peptide of the present invention is directed to is pseudomonas aeruginosa, staphylococcus epidermis, gold
Staphylococcus aureus, gonococcus, hemolytic streptococcus and Propiobacterium.
The present invention additionally provides a kind of VR glasses devices, include the eyeshade shell for wearing；The eyeshade shell is human body
Facial curved-surface structure, it is characterised in that: surface is coated with antimicrobial polypeptide, the sequence of the antimicrobial polypeptide such as SEQ
Shown in ID NO:1-8 is any.
Above-mentioned antimicrobial peptide can be by artificial synthesized, i.e., the method or gene engineering method of Solid-phase synthesis peptides obtain.
By realizing by spraying, described is to spray VR lens surface by spray film forming agent to realize by spraying for the coating.
The component of film forming agent are as follows: antimicrobial peptide 100ppm, polyvinyl alcohol 2wt%, polyvinylpyrrolidone 5wt%, and
Glycerol 10wt%, water surplus；It is any shown that the antimicrobial peptide addressed is selected from SEQ ID NO:1-8.
The preparation method of antimicrobial peptide spray film forming agent of the invention, includes the following steps:
(1) water-soluble, film-forming high molecular material is dissolved in hot water；
(2) moisturizer and configured good antibacterial peptide aqueous solution is added, is uniformly mixed, it is filling in sprayer.
The beneficial effects of the present invention are:
Antimicrobial peptide spray film forming agent provided by the invention is sprayed on after VR glasses and forms thin film in a few minutes, right
Glasses not only act as direct protective effect, kill bacterium rapidly, prevent the infection of glasses bacterium, and the film has skin
Good compatibility and gas permeability；The spray film forming agent contains moisturizer ingredient, can absorb moisture, plays preferable moisturizing and makees
With.In addition antimicrobial peptide bacteriostatic activity is high, low in cost, can promote the use of on a large scale, has great application prospect
It is worth with important social value.
Specific embodiment
The preparation and activity verifying of embodiment antimicrobial peptide
The antimicrobial peptide SEQ ID NO:1-8 screened early period according to applicant entrusts the raw work in Shanghai using admittedly respectively
Phase synthesi synthesis, and by C-terminal amidation, it is purified after synthesis through HPLC, purity reaches 99.0%.
Antibiotic property detection:
It is 100ppm that polypeptide, which is dissolved into concentration with distilled water, carries out antibacterial activity detection using agar diffusion method.Fine jade
Bacterial strain used in lipolysaccharide diffusion method is pseudomonas aeruginosa, staphylococcus epidermis, staphylococcus aureus, gonococcus, haemolysis
The combination of property streptococcus and Propiobacterium.After bacterial strain recovery, it is inoculated in after culture medium post activation culture bacterial strain obtains culture solution
50 microlitres of bacterium solutions are taken to be coated on solid medium respectively.After standing band bacterium solution absorption, it is separately added into the polypeptide solution 10 of 100ppm
Microlitre.After 37 DEG C are cultivated 1 hour, the presence or absence of observation inhibition zone and size.It the results are shown in Table 1.
1 polypeptide Analysis of Antimicrobial Activity result of table
As it can be seen from table 1 AMP-1~8 all have preferable antibacterial characteristics.
The hemolytic of antimicrobial peptide detects
Utilize the haemocylolysis of sheeps blood erythrocyte detection antimicrobial peptide；The antimicrobial peptide AMP- for being 100ppm by concentration
1~810 microlitre is added dropwise in blood dish surface, is compareed with distilled water.It is placed in 37 DEG C 24 hours or more, then observes haemolysis circle
The presence or absence of.As a result all tested antimicrobial peptides do not occur haemolysis circle.PRELIMINARY RESULTS shows that the antimicrobial peptide is not deposited
In hemolytic toxicity.
The preparation of peptide modified VR glasses
Polyvinyl alcohol 2wt%, polyvinylpyrrolidone 5wt% are first dissolved, then by antimicrobial peptide 100ppm and sweet
Oily 10wt% is mixed, water surplus, and it is any shown that the antimicrobial peptide addressed is selected from SEQ ID NO:1-8.It is uniformly mixed, it is filling
In in sprayer.
VR glasses device is taken, the spraying of eyeshade shell surface is covered with to the spray for stating preparation, peptide film can be formed on surface.Not have
There are the VR glasses of coating peptide film for control, glasses are placed in the experience Room respectively, per per day usage amount in 200 people or so, respectively
It scrapes 1*1cm surface area and carries out bacterium colony analysis, found by analysis, surface coats the VR lens surface of peptide film substantially without pathogenic
Bacterium, and there is numerous pathogenic bacteria, respectively pseudomonas aeruginosa, Staphylococcus aureus for the lens surface of uncoated mycoderm
Bacterium, gonococcus, hemolytic streptococcus and Propiobacterium, bacterium colony number have reached 2.0*103Left and right.It can from result above
Out, VR glasses of the invention have preferable bactericidal effect.
The above are specific embodiments of the present invention, its role is to be further described in detail to the contents of the present invention,
It is more readily understood reader, but is not constituted to protection of the presently claimed invention.
Sequence table
<110>Li Zhongbo
<120>a kind of VR glasses
<160> 8
<170> SIPOSequenceListing 1.0
<210> 1
<211> 24
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 1
Met Cys Cys Pro Thr Thr His His Thr Asn His Val Met Ala Gly Trp
1 5 10 15
Gln Ile Gln Arg Trp Met His Thr
20
<210> 2
<211> 27
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 2
Pro Gly Cys Tyr Tyr Ile Asp His Pro Pro Pro Phe Leu Asp Pro Phe
1 5 10 15
Ser Ser Leu Thr Phe Cys Gln Glu Val Asn Val
20 25
<210> 3
<211> 27
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 3
Asn His Arg Ser Pro Thr Trp Pro His Tyr Asp Leu Ala Ser Gln Leu
1 5 10 15
Pro Cys Asp Arg Cys Gln Trp Arg Glu Asn Pro
20 25
<210> 4
<211> 26
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 4
Ala Val Ser Ala Ile Pro Trp Asn Ala Ala Trp Ala Thr Pro Met His
1 5 10 15
Val Thr Tyr Lys Pro Arg Gly His Pro Glu
20 25
<210> 5
<211> 28
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 5
Ile His Glu Trp His Ile Trp Met Gly Ile Pro Ser Trp Val Pro Trp
1 5 10 15
Gln Trp Pro Gln His His His Glu Leu Val Pro Met
20 25
<210> 6
<211> 26
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 6
Ile His Gly Arg Arg Phe Pro Met Asp His Arg Ile Asp His Arg Tyr
1 5 10 15
Val Ser Lys Thr Leu Ile Ser Ala Pro Leu
20 25
<210> 7
<211> 25
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 7
Ala Ser Arg Glu Thr Pro Asp Ser Pro Cys Arg Ser Lys Lys Ile Met
1 5 10 15
Thr Ser Met Arg Tyr Arg Ala Trp Pro
20 25
<210> 8
<211> 27
<212> PRT
<213>artificial sequence (2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 8
Trp Ala Leu Met His Lys Ser Gln Trp Ser Trp Phe Ile Val Pro His
1 5 10 15
Cys Ile His His Leu Asp Cys Ala Ser Ile Pro
20 25
Claims (4)
1. a kind of VR glasses, it is characterised in that: include the eyeshade shell for wearing；The eyeshade shell is human body face curved surface knot
Structure.
2. VR glasses as described in claim 1, it is characterised in that: the eye envelope surface is coated with SEQ ID NO:3 institute
Show antimicrobial polypeptide.
Application of the antimicrobial polypeptide shown in 3.SEQ ID NO:3 in preparation antibacterial VR glasses.
4. a kind of polypeptide, sequence is shown in SEQ ID NO:3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811174372.0A CN109116568A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710074834.0A CN106707517B (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174372.0A CN109116568A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710074834.0A Division CN106707517B (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
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| Publication Number | Publication Date |
|---|---|
| CN109116568A true CN109116568A (en) | 2019-01-01 |
Family
ID=58909212
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| CN201811174372.0A Withdrawn CN109116568A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174460.0A Withdrawn CN109164581A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174398.5A Withdrawn CN109212758A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174412.1A Withdrawn CN109212759A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174379.2A Withdrawn CN109164580A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201710074834.0A Active CN106707517B (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174920.XA Withdrawn CN109143586A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174918.2A Withdrawn CN109239923A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811174460.0A Withdrawn CN109164581A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174398.5A Withdrawn CN109212758A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174412.1A Withdrawn CN109212759A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174379.2A Withdrawn CN109164580A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201710074834.0A Active CN106707517B (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174920.XA Withdrawn CN109143586A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
| CN201811174918.2A Withdrawn CN109239923A (en) | 2017-02-12 | 2017-02-12 | A kind of VR glasses |
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| CN101111256B (en) * | 2004-12-15 | 2012-04-25 | 科罗拉多大学 | Antimicrobial peptides and methods of use |
| CN105622741A (en) * | 2014-10-28 | 2016-06-01 | 无锡灵锡医疗器械科技有限公司 | Preparation method of composition for contact lens surface antibacterial coating and application method |
| CN205620613U (en) * | 2016-05-13 | 2016-10-05 | 王金龙 | Wear comfortable VR glasses |
| CN205720895U (en) * | 2016-06-15 | 2016-11-23 | 深圳市鼎烨源信息科技有限公司 | A kind of VR glasses device |
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2017
- 2017-02-12 CN CN201811174372.0A patent/CN109116568A/en not_active Withdrawn
- 2017-02-12 CN CN201811174460.0A patent/CN109164581A/en not_active Withdrawn
- 2017-02-12 CN CN201811174398.5A patent/CN109212758A/en not_active Withdrawn
- 2017-02-12 CN CN201811174412.1A patent/CN109212759A/en not_active Withdrawn
- 2017-02-12 CN CN201811174379.2A patent/CN109164580A/en not_active Withdrawn
- 2017-02-12 CN CN201710074834.0A patent/CN106707517B/en active Active
- 2017-02-12 CN CN201811174920.XA patent/CN109143586A/en not_active Withdrawn
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| Publication number | Publication date |
|---|---|
| CN109143586A (en) | 2019-01-04 |
| CN106707517A (en) | 2017-05-24 |
| CN109212759A (en) | 2019-01-15 |
| CN109164580A (en) | 2019-01-08 |
| CN106707517B (en) | 2019-12-03 |
| CN109212758A (en) | 2019-01-15 |
| CN109164581A (en) | 2019-01-08 |
| CN109239923A (en) | 2019-01-18 |
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