CN109107223A - A kind of device and method being enriched with ferulic acid from Radix Angelicae Sinensis - Google Patents
A kind of device and method being enriched with ferulic acid from Radix Angelicae Sinensis Download PDFInfo
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- CN109107223A CN109107223A CN201811195233.6A CN201811195233A CN109107223A CN 109107223 A CN109107223 A CN 109107223A CN 201811195233 A CN201811195233 A CN 201811195233A CN 109107223 A CN109107223 A CN 109107223A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/36—Pervaporation; Membrane distillation; Liquid permeation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
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- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to ferulic acid enrichment plant and methods, more particularly to a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis, including funnel, funnel lower end is connected with liquid level observing pipeline, liquid level observing lower end of duct is connected with liquid switch pipeline, liquid switch pipeline is connected with fluid circulation mechanism by arc pipe, fluid circulation mechanism includes the oval ducts of vertical direction setting, set on the liquid driving device for being used to that liquid to be driven to flow of oval ducts and set on the exhaust apparatus for one-way exhaust of oval ducts, the switching regulator tap of waste liquid after oval ducts bottom is equipped with for filtering to be discharged；The present invention can separation and concentration ferulic acid, production method is simple, device structure stablize, it is easy to repair, price material benefit, while be convenient for consecutive production.
Description
Technical field
The present invention relates to ferulic acid enrichment plant and methods, and in particular to it is a kind of from Radix Angelicae Sinensis be enriched with ferulic acid equipment and
Method.
Background technique
Ferulic acid has very strong reproducibility, there is strong scavenging effect to free radical, is generally acknowledged natural safety
Antioxidant；Meanwhile ferulic acid can increase myocardial blood supply, protect ischemic myocardium, and aortal smooth muscle is inhibited to shrink
And inhibit platelet aggregation and release, inhibition thrombosis, in addition to this, ferulic acid also have blood sugar reducing function, anticancer and
The breeding of pathogenic bacteria can be effectively suppressed in anti-inflammatory effect.
Meanwhile containing ferulic acid in Radix Angelicae Sinensis, it is one of ideal raw material that content is higher, however the system of ferulic acid at present
The method of preparing for only has plant extraction method, chemical synthesis and biological synthesis process, these methods are not only at high cost, and required time is long, and
And structure is complicated for device therefor, and it is at high price, it is unsuitable for large-scale production.
Therefore, it is badly in need of a kind of novel production method and production equipment at present, is used for separation and concentration ferulic acid, production method
Simply, device structure is stablized, easy to repair, price material benefit, while being convenient for consecutive production.
Summary of the invention
The present invention provides a kind of device and method that ferulic acid is enriched with from Radix Angelicae Sinensis, can separation and concentration ferulic acid, it is raw
Production mode is simple, and device structure is stablized, easy to repair, price material benefit, while being convenient for consecutive production.
The present invention adopts the following technical scheme:
A kind of equipment being enriched with ferulic acid from Radix Angelicae Sinensis, including funnel, funnel lower end are connected with liquid level observing pipeline, and liquid level is seen
It surveys lower end of duct and is connected with liquid switch pipeline, liquid switch pipeline is connected with fluid circulation mechanism, liquid by arc pipe
Body circulation mechanism includes the oval ducts of vertical direction setting, the liquid for driving liquid to flow set on oval ducts
Driving device and the exhaust apparatus for one-way exhaust set on oval ducts, oval ducts bottom are equipped with for being discharged
The switching regulator tap of waste liquid after filter；Fluid circulation mechanism lower end, which is connected with, filters liquid circulation by cross-flow filtration mode
The cross-flow filtration device of liquid in mechanism, cross-flow filtration device include the upper cartridge body being connected with fluid circulation mechanism, with it is upper
The lower frame body that box body connects and the clamping frame for clamping molecularly imprinted composite membrane；Clamping frame includes upper frame and lower frame
Frame, molecularly imprinted composite membrane are mounted between frame and lower frame, by the clamping of upper frame and lower frame to molecular engram
Composite membrane is fixed；The sliding slot for installing clamping frame is equipped in lower frame body；Lower frame body lower end is connected with for storing
The reserve tank of filtrate, reserve tank side are connected with the drainage tube for draining filtered fluid；Drainage tube one end is connect with reserve tank, separately
One end is equipped with the drainage-fluid heating mechanism for receiving drainage-fluid and heating.
Further, drainage-fluid heating mechanism includes drainage-fluid Storage Cup and the heating dress for heating drainage-fluid Storage Cup
It sets；Heating device is water bath heating device；The heating temperature of heating device is not higher than 95 DEG C.
Further, drainage tube is soft materials, and rubber material can be used, and passes through clamp rubber convenient for operator
The drainage flow of the drainage tube control liquid of material, directly can close drainage tube with clamp if necessary.
Preferably, oval ducts upper end is parallel with liquid level observing pipeline upper end, and liquid level observing pipeline is transparent plastic material
Matter；Liquid level observing pipeline is glass material.
A method of it being enriched with ferulic acid from Radix Angelicae Sinensis, comprising the following steps:
(1) using PVC as the preparation of the ferulic acid molecularly imprinted composite membrane of basement membrane: first by polyvinyl chloride (PVC) film (220mm*
It 120mm) is placed in the methanol solution of 0.05mol/L azodiisobutyronitrile after impregnating 30min and is dried in 30 DEG C of baking oven；Simultaneously
0.4000g imprinted templates molecule ferulic acid and 7.2000g function monomer-methacrylic acid is taken to pour into the acetonitrile of 30ml and stir
It reacts 1h and forms the first mixed liquor；Then 16.3320g ethylene glycol dimethacrylate, 0.2g azodiisobutyronitrile is taken to pour into
In first mixed liquor, logical nitrogen 10min is used to remove the polymerization inhibitor substance (i.e. oxygen) in the first mixed liquor, then supersonic oscillations
10min forms casting solution；Then casting solution is poured in PVC film to after standing 20min the illumination 1h under UV ultraviolet curing lamp；Finally
The imprinted templates molecule ferulic acid and unreacted of PVC film on piece are eluted with methanol-glacial acetic acid (volume ratio 9:1) mixed solution
Compound, until with UV spectrophotometer measuring less than impurity until；It is washed away on diaphragm with acetonitrile and methanol respectively again
Acetic acid obtains ferulic acid molecularly imprinted composite membrane (MIM film).
(2) method for extracting ferulic acid from Radix Angelicae Sinensis: Radix Angelicae Sinensis dried roots are taken, are crushed into powder；With 95% second of 5-10 times of weight
Alcohol refluxing extraction at least 3 times again, each time are at least 2 hours, filtering, merging filtrate, and solvent is recovered under reduced pressure and obtains extracting leaching
Cream extracts medicinal extract and is completely dissolved to obtain the first lysate with the ethanol solution that mass concentration is 15%-25%.
(3) by equipment obtained, ferulic acid molecularly imprinted composite membrane made from step (1) is fit into gripper frame
Frame, the clamping frame for installing ferulic acid molecularly imprinted composite membrane are fit into the sliding slot of lower frame body, open liquid driven dress
It sets and is run 1-2 minutes with drainage-fluid heating mechanism, equipment, open liquid switch pipeline, the first lysate of step (2) is poured into
Funnel, until the first lysate liquid level liquid level observing pipeline medium position, closing liquid switch pipeline, keep equipment fortune
Row 2-5 hours, high-content purity can be obtained in drainage-fluid Storage Cup not less than 98% ferulic acid crystal.
Meanwhile ferulic acid is enriched in such a way that another kind vertically filters, it is a kind of from Radix Angelicae Sinensis using following equipment
It is enriched with the vertical filter plant of ferulic acid: pumping out the water pump of feed liquid including batch can and from the batch can, the water pump is connected with out
Flow control valve is closed, the switch traffic control valve is connected with plate membrane separation plant；The plate membrane separation plant include into
Material mouth, the feed inlet lower end are connected with closed clamping plate mechanism, and the closed clamping plate mechanism lower end is connected with liquid storage circular groove, described
Liquid storage circular groove side is connected with discharge port；The closed clamping plate mechanism is cylindrical empty core structure, including upper clamp plate and lower clamp plate；
The clamping piece for clamping ferulic acid molecularly imprinted composite membrane is equipped in the closed clamping plate mechanism, the clamping piece is annulus knot
Structure, including upper clamping piece and lower clamping piece；The discharge port is connected with out-feed liquid heating mechanism, the out-feed liquid heating mechanism packet
It includes oil bath heating equipment and out-feed liquid for storing discharge port outflow and is heated by the heating water bath equipment
Heating Cup, the heating temperature of the out-feed liquid heating mechanism is no more than 95 DEG C.
Include: by vertical filter type enrichment ferulic acid step,
(1) using PVC as the preparation of the ferulic acid molecularly imprinted composite membrane of basement membrane: first by polyvinyl chloride (PVC) film (220mm*
It 120mm) is placed in the methanol solution of 0.05mol/L azodiisobutyronitrile after impregnating 30min and is dried in 30 DEG C of baking oven；Simultaneously
0.4000g imprinted templates molecule ferulic acid and 7.2000g function monomer-methacrylic acid is taken to pour into the acetonitrile of 30ml and stir
It reacts 1h and forms the first mixed liquor；Then 16.3320g ethylene glycol dimethacrylate, 0.2g azodiisobutyronitrile is taken to pour into
In first mixed liquor, logical nitrogen 10min is used to remove the polymerization inhibitor substance (i.e. oxygen) in the first mixed liquor, then ultrasonic wave vibration
It swings 10min and forms casting solution；Then the casting solution is poured in the PVC film after standing 20min under UV ultraviolet curing lamp
Illumination 1h；The trace mould of the PVC film on piece is finally eluted with methanol-glacial acetic acid (volume ratio 9:1) mixed solution
Plate molecule ferulic acid and unreacted compound, until with UV spectrophotometer measuring less than impurity；Use second respectively again
Nitrile and methanol wash away the acetic acid on diaphragm, obtain ferulic acid molecularly imprinted composite membrane (MIM film).
(2) method for extracting ferulic acid from Radix Angelicae Sinensis: Radix Angelicae Sinensis dried roots are taken, are crushed into powder；With 95% second of 5-10 times of weight
Alcohol refluxing extraction at least 3 times again, each time are at least 2 hours, filtering, merging filtrate, and solvent is recovered under reduced pressure and obtains extracting leaching
Cream, the extraction medicinal extract are completely dissolved to obtain the first lysate with the ethanol solution that mass concentration is 15%-25%.
(3) by using above vertical filter plant, by the ferulic acid molecularly imprinted composite membrane made from step (1)
Be fit into the clamping piece, install the ferulic acid molecularly imprinted composite membrane the clamping piece be fit into it is described under it is close
Clamping plate mechanism is closed, first lysate of step (2) is poured into the batch can, opens the water pump and out-feed liquid heating
Mechanism opens the feed inlet, keeps the equipment to run 2-5 hours, can obtain height in the out-feed liquid heating mechanism
Content and purity are higher than 98% or more ferulic acid crystal.
By the above-mentioned description to invention it is found that compared to the prior art, the present invention has the advantage that the 1, present invention passes through
Molecularly imprinted composite membrane obtained, strong to ferulic acid identity, tensile strength is strong, in the cross-flow of the liquid of equipment of the invention
Under filtering, not only filter efficiency is high, but also molecularly imprinted composite membrane is not easily broken, when enhancing the work of molecularly imprinted composite membrane
It is long, production cost is reduced, production efficiency is improved, meanwhile, obtained filtered fluid ferulaic acid content is high, is further heating
The ferulic acid crystal of high-content high-purity is obtained afterwards.2, cross-flow filtration equipment simple structure of the invention is supplied convenient for equipment
Quotient's large-scale production and maintenance, at the same it is easy to operate, after filtering, tap need to be only opened, waste liquid is discharged, then pass through funnel
Be added new liquid to be filtered can continuity cross-flow filtration carried out by molecular engram film.
Detailed description of the invention
Fig. 1 is present device perspective view 1；
Fig. 2 is the cross-sectional view of present device perspective view 1；
Fig. 3 is present device perspective view 2；
Fig. 4 is the cross-sectional view of present device perspective view 2；
Fig. 5 is present device front view；
Fig. 6 is the cross-sectional view of present device front view；
Fig. 7 is the perspective view of the vertical filter plant of the present invention；
Fig. 8 is the sectional view of the vertical filter plant of the present invention；
Fig. 9 is flow chart of the present invention using vertical filter plant.
Specific embodiment
Illustrate a specific embodiment of the invention with reference to the accompanying drawings.
Embodiment one:
Referring to Fig. 1 to Fig. 6, a kind of equipment being enriched with ferulic acid from Radix Angelicae Sinensis, including funnel 1,1 lower end of funnel are connected with liquid level
Pipeline 11 is observed, 11 lower end of liquid level observing pipeline is connected with liquid switch pipeline 12, and liquid switch pipeline 12 passes through curved pipe
Road 13 is connected with fluid circulation mechanism 2, and fluid circulation mechanism 2 includes the oval ducts 21 of vertical direction setting, is set to ellipse
The liquid driving device 22 for driving liquid to flow of shape pipeline 21 and set on oval ducts 21 for one-way exhaust
Exhaust apparatus 23, the switching regulator tap 24 of waste liquid after 21 bottom of oval ducts is equipped with for filtering to be discharged；Liquid follows
2 lower end of ring mechanism is connected with the cross-flow filtration device 3 that liquid in fluid circulation mechanism 2 is filtered by cross-flow filtration mode, cross-flow
Filter device 3 includes the upper cartridge body 31 being connected with fluid circulation mechanism 2, the lower frame body 32 connecting with upper cartridge body 31 and is used for
Clamp the clamping frame 33 of molecularly imprinted composite membrane；The sliding slot 34 for installing clamping frame 33 is equipped in lower frame body 32；Lower frame
32 lower end of body is connected with the reserve tank 35 for storing filtered fluid, and 35 side of reserve tank is connected with the drainage for draining filtered fluid
Pipe 36；36 one end of drainage tube is connect with reserve tank 35, and the other end is equipped with the drainage-fluid heater for receiving drainage-fluid and heating
Structure 4.
Referring to Fig. 1 to Fig. 6, drainage-fluid heating mechanism 4 is including drainage-fluid Storage Cup 41 and for heating drainage-fluid Storage Cup
Heating device 42；Heating device 42 is water bath heating device；The heating temperature of heating device 42 is not higher than 95 DEG C.Drainage tube 36
For soft materials, rubber tube can be used, drawing for liquid is controlled by the drainage tube 36 of clamp rubber tube convenient for operator
Flow directly can close drainage tube 36 with clamp if necessary；21 upper end of oval ducts and liquid level observing pipeline 11
Upper end is parallel, and liquid level observing pipeline 11 is transparent plastics material；Liquid level observing pipeline 11 is glass material.
The method of ferulic acid is enriched with from Radix Angelicae Sinensis, comprising the following steps:
(1) using PVC as the preparation of the ferulic acid molecularly imprinted composite membrane of basement membrane: first by polyvinyl chloride (PVC) film (220mm*
It 120mm) is placed in the methanol solution of 0.05mol/L azodiisobutyronitrile after impregnating 30min and is dried in 30 DEG C of baking oven；Simultaneously
0.4000g imprinted templates molecule ferulic acid and 7.2000g function monomer-methacrylic acid is taken to pour into the acetonitrile of 30ml and stir
It reacts 1h and forms the first mixed liquor；Then 16.3320g ethylene glycol dimethacrylate, 0.2g azodiisobutyronitrile is taken to pour into
In first mixed liquor, logical nitrogen 10min is used to remove the polymerization inhibitor substance (i.e. oxygen) in the first mixed liquor, then supersonic oscillations
10min forms casting solution；Then casting solution is poured in PVC film to after standing 20min the illumination 1h under UV ultraviolet curing lamp；Finally
The imprinted templates molecule ferulic acid and unreacted of PVC film on piece are eluted with methanol-glacial acetic acid (volume ratio 9:1) mixed solution
Compound, until with UV spectrophotometer measuring less than impurity until；It is washed away on diaphragm with acetonitrile and methanol respectively again
Acetic acid obtains ferulic acid molecularly imprinted composite membrane (MIM film).
(2) method for extracting ferulic acid from Radix Angelicae Sinensis: Radix Angelicae Sinensis dried roots are taken, are crushed into powder；With 95% second of 5-10 times of weight
Alcohol refluxing extraction at least 3 times again, each time are at least 2 hours, filtering, merging filtrate, and solvent is recovered under reduced pressure and obtains extracting leaching
Cream extracts medicinal extract and is completely dissolved to obtain the first lysate with the ethanol solution that mass concentration is 15%-25%.
(3) by equipment obtained, ferulic acid molecularly imprinted composite membrane made from step (1) is fit into clamping frame
33, the clamping frame 33 for installing ferulic acid molecularly imprinted composite membrane is fit into the sliding slot of lower frame body 32, is opened liquid and is driven
Dynamic device 22 and drainage-fluid heating mechanism, equipment are run 1-2 minutes, open liquid switch pipeline 12, molten by the first of step (2)
Solution liquid pour into funnel 1, until the first lysate liquid level liquid level observing pipeline 11 medium position, closing liquid switch pipeline
12, it keeps equipment to run 2-5 hours, high-content purity can be obtained in drainage-fluid Storage Cup not less than 98% asafoetide acid crystal
Object.
Embodiment two:
Referring to Fig. 7 to Fig. 9, a kind of vertical filter plant from Radix Angelicae Sinensis enrichment ferulic acid: pumped including batch can 201 and from batch can 201
The water pump 202 of out-feed liquid, water pump 202 are connected with switch traffic control valve 203, and switch traffic control valve 203 is connected with plate membrane
Separation equipment 204；Plate membrane separation plant 204 includes feed inlet 2041, and 2041 lower end of feed inlet is connected with closed clamping plate mechanism
2042, closed 2042 lower end of clamping plate mechanism is connected with liquid storage circular groove 2043, and 2043 side of liquid storage circular groove is connected with discharge port 2044；
Closed clamping plate mechanism 2042 is cylindrical empty core structure, including upper clamp plate 20421 and lower clamp plate 20422；Closed clamping plate mechanism
The clamping piece 2045 for clamping ferulic acid molecularly imprinted composite membrane 20423 is equipped in 2042, clamping piece 2045 is circular ring structure,
Including upper clamping piece 20451 and lower clamping piece 20452；Discharge port 2044 is connected with out-feed liquid heating mechanism 205, out-feed liquid heating
Mechanism 205 includes oil bath heating equipment and out-feed liquid for storing the outflow of discharge port 2044 and is carried out by oil bath heating equipment
The Heating Cup of heating, the heating temperature of out-feed liquid heating mechanism 205 are no more than 95 DEG C.
Being enriched with ferulic acid step by vertical filter type includes:
(1) using PVC as the preparation of the ferulic acid molecularly imprinted composite membrane of basement membrane: first by polyvinyl chloride (PVC) film (220mm*
It 120mm) is placed in the methanol solution of 0.05mol/L azodiisobutyronitrile after impregnating 30min and is dried in 30 DEG C of baking oven；Simultaneously
0.4000g imprinted templates molecule ferulic acid and 7.2000g function monomer-methacrylic acid is taken to pour into the acetonitrile of 30ml and stir
It reacts 1h and forms the first mixed liquor；Then 16.3320g ethylene glycol dimethacrylate, 0.2g azodiisobutyronitrile is taken to pour into
In first mixed liquor, logical nitrogen 10min is used to remove the polymerization inhibitor substance (i.e. oxygen) in the first mixed liquor, then supersonic oscillations
10min forms casting solution；Then casting solution is poured in PVC film to after standing 20min the illumination 1h under UV ultraviolet curing lamp；Finally
The imprinted templates molecule ferulic acid and unreacted of PVC film on piece are eluted with methanol-glacial acetic acid (volume ratio 9:1) mixed solution
Compound, until with UV spectrophotometer measuring less than impurity until；It is washed away on diaphragm with acetonitrile and methanol respectively again
Acetic acid obtains ferulic acid molecularly imprinted composite membrane (MIM film).
(2) method for extracting ferulic acid from Radix Angelicae Sinensis: Radix Angelicae Sinensis dried roots are taken, are crushed into powder；With 95% second of 5-10 times of weight
Alcohol refluxing extraction at least 3 times again, each time are at least 2 hours, filtering, merging filtrate, and solvent is recovered under reduced pressure and obtains extracting leaching
Cream extracts medicinal extract and is completely dissolved to obtain the first lysate with the ethanol solution that mass concentration is 15%-25%.
(3) by using above vertical filter plant, by ferulic acid molecularly imprinted composite membrane made from step (1)
20423 are fit into clamping piece 2045, and the clamping piece 2045 for installing ferulic acid molecularly imprinted composite membrane 20423 is fit into down
First lysate of step (2) is poured into batch can, opens water pump 202 and out-feed liquid heating mechanism by closed clamping plate mechanism 2042
205, open feed inlet 2041, keep equipment run 2-5 hours, can be obtained in out-feed liquid heating mechanism 205 high-content and
Purity is higher than 98% or more ferulic acid crystal.
The above is only a specific embodiment of the present invention, but the design concept of the present invention is not limited to this, all to utilize this
Design makes a non-material change to the present invention, and should all belong to behavior that violates the scope of protection of the present invention.
Claims (10)
1. a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis, including funnel, it is characterized in that: the funnel lower end is connected with liquid level
Pipeline is observed, the liquid level observing lower end of duct is connected with liquid switch pipeline, and the liquid switch pipeline passes through curved pipe
Road is connected with fluid circulation mechanism, and the fluid circulation mechanism includes the oval ducts of vertical direction setting, set on described ellipse
The liquid driving device for driving liquid to flow of circular pipe and set on the oval ducts for one-way exhaust
Exhaust apparatus；The fluid circulation mechanism lower end, which is connected with, filters liquid in the fluid circulation mechanism by cross-flow filtration mode
Cross-flow filtration device, the cross-flow filtration device include the upper cartridge body being connected with the fluid circulation mechanism, with it is described
The lower frame body that upper cartridge body connects and the clamping frame for clamping molecularly imprinted composite membrane；It is equipped in the lower frame body for installing
The sliding slot of the clamping frame；The lower frame body lower end is connected with the reserve tank for storing filtered fluid, the reserve tank side
It is connected with the drainage tube for draining filtered fluid；Described drainage tube one end is connect with the reserve tank, and the other end is equipped with for connecing
Receive drainage-fluid and heat drainage-fluid heating mechanism.
2. a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis according to claim 1, it is characterized in that: the drainage-fluid heater
Structure includes drainage-fluid Storage Cup and the heating device for heating the drainage-fluid Storage Cup.
3. a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis according to claim 2, it is characterized in that: the heating device is water
Bathe heating device.
4. a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis according to claim 2, it is characterized in that: the heating device adds
Hot temperature is not higher than 95 DEG C.
5. a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis according to claim 1, it is characterized in that: the drainage tube is soft
Material.
6. according to claim 1 or 3 or 5 a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis, it is characterized in that: the ellipse
Pipeline upper end is parallel with liquid level observing pipeline upper end, and the liquid level observing pipeline is transparent plastics material.
7. a kind of equipment for being enriched with ferulic acid from Radix Angelicae Sinensis according to claim 6, it is characterized in that: the liquid level observing pipeline
For glass material.
8. a kind of method for being enriched with ferulic acid from Radix Angelicae Sinensis, it is characterised in that the following steps are included:
(1) using PVC as the preparation of the ferulic acid molecularly imprinted composite membrane of basement membrane: first by polyvinyl chloride (PVC) film (220mm*
It 120mm) is placed in the methanol solution of 0.05mol/L azodiisobutyronitrile after impregnating 30min and is dried in 30 DEG C of baking oven；Simultaneously
It takes 0.4000g imprinted templates molecule ferulic acid and 7.2000g function monomer-methacrylic acid to pour into the acetonitrile of 30ml to stir instead
1h is answered to form the first mixed liquor；Then 16.3320g ethylene glycol dimethacrylate, 0.2g azodiisobutyronitrile is taken to pour into institute
It states in the first mixed liquor, logical nitrogen 10min is used to remove the polymerization inhibitor substance (i.e. oxygen) in the first mixed liquor, then supersonic oscillations
10min forms casting solution；Then the casting solution is poured in the PVC film to after standing 20min the light under UV ultraviolet curing lamp
According to 1h；The imprinted templates of the PVC film on piece are finally eluted with methanol-glacial acetic acid (volume ratio 9:1) mixed solution
Molecule ferulic acid and unreacted compound, until with UV spectrophotometer measuring less than impurity；Use acetonitrile respectively again
The acetic acid on diaphragm is washed away with methanol, obtains ferulic acid molecularly imprinted composite membrane (MIM film)；
(2) method for extracting ferulic acid from Radix Angelicae Sinensis: Radix Angelicae Sinensis dried roots are taken, are crushed into powder；With 95% ethyl alcohol of 5-10 times of weight
Refluxing extraction at least 3 times again, each time are at least 2 hours, filtering, merging filtrate, and solvent is recovered under reduced pressure and obtains extracting medicinal extract,
The extraction medicinal extract is completely dissolved to obtain the first lysate with the ethanol solution that mass concentration is 15%-25%；
(3) equipment provided according to claim 3, the ferulic acid molecularly imprinted composite membrane made from step (1) is installed into
Enter the clamping frame, the clamping frame for installing the ferulic acid molecularly imprinted composite membrane is fit into the lower frame body
The sliding slot in, open the liquid driving device and the drainage-fluid heating mechanism, the equipment is run 1-2 minutes, is beaten
The liquid switch pipeline is opened, first lysate of step (2) is poured into the funnel, until first lysate
Liquid level closes the liquid switch pipeline in the medium position of the liquid level observing pipeline, keeps the equipment operation 2-5 small
When, the ferulic acid crystal that high-content purity is not less than 98% can be obtained in the drainage-fluid Storage Cup.
9. a kind of vertical filter plant from Radix Angelicae Sinensis enrichment ferulic acid: the water pump of feed liquid is pumped out including batch can and from the batch can,
The water pump is connected with switch traffic control valve, it is characterized in that: the switch traffic control valve is connected with plate membrane separation plant；
The plate membrane separation plant includes feed inlet, and the feed inlet lower end is connected with closed clamping plate mechanism, the closed clamping plate machine
Structure lower end is connected with liquid storage circular groove, and liquid storage circular groove side is connected with discharge port；The closed clamping plate mechanism is cylindrical empty
Core structure, including upper clamp plate and lower clamp plate；It is equipped in the closed clamping plate mechanism for clamping ferulic acid molecularly imprinted composite membrane
Clamping piece, the clamping piece is circular ring structure, including upper clamping piece and lower clamping piece；The discharge port is connected with out-feed liquid and adds
Heat engine structure, the out-feed liquid heating mechanism include oil bath heating equipment and the out-feed liquid for storing discharge port outflow plus
Hot cup.
10. a kind of method for being enriched with ferulic acid from Radix Angelicae Sinensis, it is characterised in that the following steps are included:
(1) using PVC as the preparation of the ferulic acid molecularly imprinted composite membrane of basement membrane: first by polyvinyl chloride (PVC) film (220mm*
It 120mm) is placed in the methanol solution of 0.05mol/L azodiisobutyronitrile after impregnating 30min and is dried in 30 DEG C of baking oven；Simultaneously
It takes 0.4000g imprinted templates molecule ferulic acid and 7.2000g function monomer-methacrylic acid to pour into the acetonitrile of 30ml to stir instead
1h is answered to form the first mixed liquor；Then 16.3320g ethylene glycol dimethacrylate, 0.2g azodiisobutyronitrile is taken to pour into institute
It states in the first mixed liquor, logical nitrogen 10min is used to remove the polymerization inhibitor substance (i.e. oxygen) in the first mixed liquor, then supersonic oscillations
10min forms casting solution；Then the casting solution is poured in the PVC film to after standing 20min the light under UV ultraviolet curing lamp
According to 1h；The imprinted templates of the PVC film on piece are finally eluted with methanol-glacial acetic acid (volume ratio 9:1) mixed solution
Molecule ferulic acid and unreacted compound, until with UV spectrophotometer measuring less than impurity；Use acetonitrile respectively again
The acetic acid on diaphragm is washed away with methanol, obtains ferulic acid molecularly imprinted composite membrane (MIM film)；
(2) method for extracting ferulic acid from Radix Angelicae Sinensis: Radix Angelicae Sinensis dried roots are taken, are crushed into powder；With 95% ethyl alcohol of 5-10 times of weight
Refluxing extraction at least 3 times again, each time are at least 2 hours, filtering, merging filtrate, and solvent is recovered under reduced pressure and obtains extracting medicinal extract,
The extraction medicinal extract is completely dissolved to obtain the first lysate with the ethanol solution that mass concentration is 15%-25%；
(3) equipment provided according to claim 9, the ferulic acid molecularly imprinted composite membrane made from step (1) is installed into
Enter the clamping piece, install the ferulic acid molecularly imprinted composite membrane the clamping piece be fit into it is described under closed clamping plate
First lysate of step (2) is poured into the batch can, opens the water pump and the out-feed liquid heating mechanism by mechanism,
The feed inlet is opened, keeps the equipment to run 2-5 hours, it is pure high-content can be obtained in the out-feed liquid heating mechanism
Degree is not less than 98% ferulic acid crystal.
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