CN109106827A - A kind of preparation method and applications for the biological agent having no drug resistance - Google Patents
A kind of preparation method and applications for the biological agent having no drug resistance Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a kind of preparation method and applications of biological agent having no drug resistance, and are related to new medicine field；Chinese medicine material is uniformly mixed, it is put into food steamer and steams, it is sterilized after steaming using ultraviolet light irradiation, it is broken into powder with crusher after sterilization, after freezing, alcohol reflux is added and extracts, centrifugal filtration, the first filtrate and the first sediment are collected, alcohol reflux is added in the first sediment and is extracted, centrifugal filtration, collect the second filtrate, first filtrate and the second filtrate are merged, is sterilized using autoclaving and assistant activator is uniformly mixed, continue to sterilize using autoclaving, water for injection stirring is added, the biological agent is made in centrifugal filtration after stirring；The biological agent drug effect of preparation is fast, Small side effects, for treating acute urticaria.
Description
Technical field:
The present invention relates to new medicine fields, and in particular to a kind of preparation method of the biological agent having no drug resistance and its answers
With.
Background technique:
With all kinds of carbon-based biologies that there is doctor to grind value for raw material, is manufactured, made using traditional technology or modern biotechnology
The various forms preparation of prevention (health care), treatment and diagnosis for all kinds of physiological signs of human body, is referred to as biological agent.
Nettle rash is commonly called as wheal.It is due to a kind of office that skin, the expansion of mucous membrane thin vessels and permeability increase and occur
Sex-limited oedema reaction, usually subsides in 2~24 hours, but repeated new fash.The protracted course a few days to months.It is clinical
It is upper relatively conventional.Basic lesions are that skin wheal occurs.Often first there is pruitus, occur wheal immediately, is in cerise or pale
Color, skin-color, small number of patients have edematous erythema.The size and form of wheal are different, and duration of seizure is indefinite.Wheal is gradually climing
Prolong, fusion in flakes, due to papilla oedema, it is seen that epidermis follicular orifice is to lower recess.Wheal last for several minutes is few to a few hours
Number subsides after can extending to a couple of days, leaves no trace.Fash occurs in batch repeatedly, common to send out author at dusk.The normal general hair of wheal, also
It can limit to.Sometimes merge angioedema, wind group surface forms bleb once in a while.
The treatment of nettle rash can also be treated using Chinese medicine at present, Chinese medicine treatment mostly uses oral traditional Chinese medicine liquid, this mouth
Taking traditional Chinese medicine, it is relatively slow to take effect, and does not have good therapeutic effect to paroxysmal nettle rash.
Summary of the invention:
Technical problem to be solved by the present invention lies in the preparation method for providing a kind of biological agent having no drug resistance and its
Using the biological agent drug effect of preparation is fast, Small side effects, has preferable therapeutic effect to paroxysmal nettle rash.
The following technical solution is employed for the technical problems to be solved by the invention to realize:
A kind of preparation method for the biological agent having no drug resistance, comprising the following steps:
(1) Chinese medicine material is uniformly mixed, is put into food steamer and steams 40- under the conditions of 60-80 DEG C, 0.3-0.4MPa
50min is sterilized using ultraviolet light irradiation after steaming, is broken into powder with crusher after sterilization, powder is added into powder
The deionized water of weight 12-15% is put at -5 DEG C and freezes 3-4h, is warming up to room temperature after freezing naturally, powder is dried；
(2) 12-15 times of powder weight of ethyl alcohol is added into above-mentioned powder, impregnates 2-3h, refluxing extraction 3-4h was centrifuged
The first filtrate and the first sediment are collected in filter, and the first sediment is added to the ethyl alcohol of 8-10 times of its weight, refluxing extraction 1-2h,
The second filtrate is collected in centrifugal filtration, and the first filtrate and the second filtrate are merged, and recycling ethyl alcohol is concentrated under reduced pressure, and primary liquid medicine is made；
(3) primary liquid medicine is uniformly mixed with assistant activator after sterilizing using autoclaving sterilizing 50min, is continued to adopt
With autoclaving sterilizing 40min, 50 times of mixed liquor weight of water for injection is added into mixed liquor, with 1200r/min revolving speed
Stir 60-80min, centrifugal filtration after stirring, collect supernatant, by the medicinal activated carbon adsorption of supernatant, after absorption use bar
Scholar's bactericidal assay is sterilized, and the biological agent is made.
The Chinese medicine material is made of the raw material of following parts by weight: 10-20 parts of hairyvein agrimony, 5-8 parts of luffa vine, Radix Glycyrrhizae 1-2
Part, 6-9 parts of Chinese gall, 12-15 parts of wild chrysanthemum, 8-10 parts of kuh-seng, 3-5 parts of lobelia chinensis, 15-20 parts of the root of Dahurain angelica, 16-22 parts of purple perilla,
18-25 parts of dandelion, 7-10 parts of rhizoma acori graminei, 10-13 parts of Bunge Corydalis Herb, 8-10 parts of azedarach, 4-6 parts of pomelo peel, Rehmannia glutinosa 2-5
Part.
The biological agent is for treating acute urticaria.
The assistant activator is made of the raw material of following parts by weight: 25-35 parts of tea polysaccharide, 12-15 parts of sodium bicarbonate, asparagus fern
It is 18-26 parts of propylhomoserin, 12-16 parts of mountain Cape jasmine glycosides, 8-12 parts of carvacrol, 6-10 parts of ubiquinone, 4-7 parts of 4- methoxyl group coumestrol, western red
Glycosides 0.02-0.06 parts of flower.
The assistant activator the preparation method comprises the following steps:
(1) sodium bicarbonate and aspartic acid are uniformly mixed, are put into reaction kettle, deionized water is added extremely into reaction kettle
Mixed liquor volume reaches the 85% of reaction kettle volume, and reaction kettle is put into 60-80 DEG C of baking oven and reacts 3-4h, natural after reaction
It is cooled to room temperature；
(2) tea polysaccharide, mountain Cape jasmine glycosides, carvacrol are uniformly mixed, stir 30-40min under 60-80r/min revolving speed, puts
Enter -10 DEG C of freezing 1-2h, is warming up to after room temperature naturally and ubiquinone, 4- methoxyl group coumestrol, crocin are uniformly mixed, added
The deionized water for entering 2-3 times of mixture weight stirs 15-20min under 120-150r/min revolving speed in 32-36 DEG C of water-bath, stirs
Water-bath 2-3h is stood after mixing, and is centrifuged after standing, is taken supernatant liquor；
(3) solution after the supernatant of above-mentioned steps preparation and step (1) reaction is uniformly mixed, in 100-120r/min
10-15min is stirred under revolving speed, instantaneous sterilizing is carried out with pasteurization, the assistant activator is made.
The present invention provides a kind of preparation method and applications of biological agent having no drug resistance, it has the advantage that:
(1) in biological agent preparation method, raw material is subjected to low temperature, high pressure steaming, preliminary exposition raw fibre group first
It knits, then sterilizes, kill the bacterium that raw material has, freezed after being broken into powder, further decompose raw fibre tissue, then use second
Alcohol reflux extracts twice, is uniformly mixed after combined extract sterilizing with assistant activator, which had both been able to maintain the medicine of raw material
Property, and the effect of assistant activator can be played, so that the biological agent drug effect of preparation is fast, Small side effects, have to acute urticaria
Good therapeutic effect.
(2) assistant activator is added in formula of biological agent, the treatment of other raw materials in formula of biological agent can be excited living
Property, shorten treatment cycle, the biological agent of preparation is quick, Small side effects, can not only treat acute urticaria, and can
Reduce the recurrence probability of nettle rash.
(3) assistant activator use special formulation, the medical active of Chinese medicine can be excited, make pharmacological property play faster with it is stronger,
And assistant activator itself is without side-effects, in preparation method, first mixes sodium bicarbonate and aspartic acid, utilizes asparagus fern ammonia
The both sexes of acid, carboxyl and reaction of sodium bicarbonate in aspartic acid generate carboxylate and water, assistant activator are given to provide salting liquid base
Plinth enhances the stability of other raw materials, is conducive to the durability of assistant activator.
Specific embodiment:
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below
Specific embodiment is closed, the present invention is further explained.
Embodiment 1:
A kind of preparation method for the biological agent having no drug resistance, comprising the following steps:
(1) Chinese medicine material is uniformly mixed, is put into food steamer and steams 40min under the conditions of 60 DEG C, 0.3MPa, is adopted after steaming
Sterilized with ultraviolet light irradiation, be broken into powder with crusher after sterilization, into powder be added powder weight 12% go from
Sub- water is put at -5 DEG C and freezes 3h, is warming up to room temperature after freezing naturally, powder is dried；
(2) 12 times of powder weight of ethyl alcohol is added into above-mentioned powder, impregnates 2h, refluxing extraction 3h, centrifugal filtration is collected
First sediment, is added the ethyl alcohol of 8 times of its weight, refluxing extraction 1h by the first filtrate and the first sediment, and centrifugal filtration is collected
Second filtrate merges the first filtrate and the second filtrate, and recycling ethyl alcohol is concentrated under reduced pressure, and primary liquid medicine is made；
(3) primary liquid medicine is uniformly mixed with assistant activator after sterilizing using autoclaving sterilizing 50min, is continued to adopt
With autoclaving sterilizing 40min, 50 times of mixed liquor weight of water for injection is added into mixed liquor, with 1200r/min revolving speed
60min is stirred, centrifugal filtration after stirring is collected supernatant and killed the medicinal activated carbon adsorption of supernatant after absorption using bus
Bacterium method is sterilized, and the biological agent is made.
Embodiment 2:
A kind of preparation method for the biological agent having no drug resistance, comprising the following steps:
(1) Chinese medicine material is uniformly mixed, is put into food steamer and steams 50min under the conditions of 80 DEG C, 0.4MPa, is adopted after steaming
Sterilized with ultraviolet light irradiation, be broken into powder with crusher after sterilization, into powder be added powder weight 15% go from
Sub- water is put at -5 DEG C and freezes 4h, is warming up to room temperature after freezing naturally, powder is dried；
(2) 15 times of powder weight of ethyl alcohol is added into above-mentioned powder, impregnates 3h, refluxing extraction 4h, centrifugal filtration is collected
First sediment, is added the ethyl alcohol of 10 times of its weight, refluxing extraction 2h by the first filtrate and the first sediment, and centrifugal filtration is received
Collect the second filtrate, the first filtrate and the second filtrate are merged, recycling ethyl alcohol is concentrated under reduced pressure, primary liquid medicine is made；
(3) primary liquid medicine is uniformly mixed with assistant activator after sterilizing using autoclaving sterilizing 50min, is continued to adopt
With autoclaving sterilizing 40min, 50 times of mixed liquor weight of water for injection is added into mixed liquor, with 1200r/min revolving speed
80min is stirred, centrifugal filtration after stirring is collected supernatant and killed the medicinal activated carbon adsorption of supernatant after absorption using bus
Bacterium method is sterilized, and the biological agent is made.
The Chinese medicine material is made of the raw material of following parts by weight: 10 parts of hairyvein agrimony, 5 parts of luffa vine, 1 part, five times of Radix Glycyrrhizae
Son 6 parts, 12 parts of wild chrysanthemum, 8 parts of kuh-seng, 3 parts of lobelia chinensis, 15 parts of the root of Dahurain angelica, 16 parts of purple perilla, 18 parts of dandelion, 7 parts of rhizoma acori graminei,
Fourth grass 10 parts, 8 parts of azedarach, 4 parts of pomelo peel, 2 parts of Rehmannia glutinosa.
The biological agent is for treating acute urticaria.
Embodiment 3:
A kind of preparation method for the biological agent having no drug resistance, comprising the following steps:
(1) Chinese medicine material is uniformly mixed, is put into food steamer and steams 45min under the conditions of 70 DEG C, 0.3MPa, is adopted after steaming
Sterilized with ultraviolet light irradiation, be broken into powder with crusher after sterilization, into powder be added powder weight 13% go from
Sub- water is put at -5 DEG C and freezes 3h, is warming up to room temperature after freezing naturally, powder is dried；
(2) 13 times of powder weight of ethyl alcohol is added into above-mentioned powder, impregnates 3h, refluxing extraction 3h, centrifugal filtration is collected
First sediment, is added the ethyl alcohol of 9 times of its weight, refluxing extraction 1h by the first filtrate and the first sediment, and centrifugal filtration is collected
Second filtrate merges the first filtrate and the second filtrate, and recycling ethyl alcohol is concentrated under reduced pressure, and primary liquid medicine is made；
(3) primary liquid medicine is uniformly mixed with assistant activator after sterilizing using autoclaving sterilizing 50min, is continued to adopt
With autoclaving sterilizing 40min, 50 times of mixed liquor weight of water for injection is added into mixed liquor, with 1200r/min revolving speed
70min is stirred, centrifugal filtration after stirring is collected supernatant and killed the medicinal activated carbon adsorption of supernatant after absorption using bus
Bacterium method is sterilized, and the biological agent is made.
The Chinese medicine material is made of the raw material of following parts by weight: 20 parts of hairyvein agrimony, 8 parts of luffa vine, 2 parts, five times of Radix Glycyrrhizae
Son 9 parts, 15 parts of wild chrysanthemum, 10 parts of kuh-seng, 5 parts of lobelia chinensis, 20 parts of the root of Dahurain angelica, 22 parts of purple perilla, 25 parts of dandelion, 10 parts of rhizoma acori graminei,
13 parts of Bunge Corydalis Herb, 10 parts of azedarach, 6 parts of pomelo peel, 5 parts of Rehmannia glutinosa.
The assistant activator is made of the raw material of following parts by weight: 25 parts of tea polysaccharide, 12 parts of sodium bicarbonate, aspartic acid 18
Part, 12 parts of mountain Cape jasmine glycosides, 8 parts of carvacrol, 6 parts of ubiquinone, 4 parts of 4- methoxyl group coumestrol, 0.02 part of crocin.
The assistant activator the preparation method comprises the following steps:
(1) sodium bicarbonate and aspartic acid are uniformly mixed, are put into reaction kettle, deionized water is added extremely into reaction kettle
Mixed liquor volume reaches the 85% of reaction kettle volume, and reaction kettle is put into 60 DEG C of baking ovens and reacts 3h, natural cooling after reaction
To room temperature；
(2) tea polysaccharide, mountain Cape jasmine glycosides, carvacrol are uniformly mixed, stir 30min under 60r/min revolving speed, is put into -10 DEG C
1h is freezed, is warming up to after room temperature naturally and ubiquinone, 4- methoxyl group coumestrol, crocin is uniformly mixed, mixture weight is added
2 times of deionized water of amount, stirs 15min under 120r/min revolving speed in 32 DEG C of water-baths, stands water-bath 2h after stirring, after standing from
The heart takes supernatant liquor；
(3) solution after the supernatant of above-mentioned steps preparation and step (1) reaction is uniformly mixed, in 100r/min revolving speed
Lower stirring 10min carries out instantaneous sterilizing with pasteurization, the assistant activator is made.
The biological agent is for treating acute urticaria.
Embodiment 4:
A kind of preparation method for the biological agent having no drug resistance, comprising the following steps:
(1) Chinese medicine material is uniformly mixed, is put into food steamer and steams 50min under the conditions of 60 DEG C, 0.4MPa, is adopted after steaming
Sterilized with ultraviolet light irradiation, be broken into powder with crusher after sterilization, into powder be added powder weight 12% go from
Sub- water is put at -5 DEG C and freezes 4h, is warming up to room temperature after freezing naturally, powder is dried；
(2) 13 times of powder weight of ethyl alcohol is added into above-mentioned powder, impregnates 2h, refluxing extraction 3h, centrifugal filtration is collected
First sediment, is added the ethyl alcohol of 9 times of its weight, refluxing extraction 1h by the first filtrate and the first sediment, and centrifugal filtration is collected
Second filtrate merges the first filtrate and the second filtrate, and recycling ethyl alcohol is concentrated under reduced pressure, and primary liquid medicine is made；
(3) primary liquid medicine is uniformly mixed with assistant activator after sterilizing using autoclaving sterilizing 50min, is continued to adopt
With autoclaving sterilizing 40min, 50 times of mixed liquor weight of water for injection is added into mixed liquor, with 1200r/min revolving speed
70min is stirred, centrifugal filtration after stirring is collected supernatant and killed the medicinal activated carbon adsorption of supernatant after absorption using bus
Bacterium method is sterilized, and the biological agent is made.
The Chinese medicine material is made of the raw material of following parts by weight: 15 parts of hairyvein agrimony, 6 parts of luffa vine, 1 part, five times of Radix Glycyrrhizae
Son 7 parts, 13 parts of wild chrysanthemum, 9 parts of kuh-seng, 4 parts of lobelia chinensis, 18 parts of the root of Dahurain angelica, 19 parts of purple perilla, 22 parts of dandelion, 7 parts of rhizoma acori graminei,
Fourth grass 13 parts, 9 parts of azedarach, 5 parts of pomelo peel, 3 parts of Rehmannia glutinosa.
The assistant activator is made of the raw material of following parts by weight: 35 parts of tea polysaccharide, 15 parts of sodium bicarbonate, aspartic acid 26
Part, 16 parts of mountain Cape jasmine glycosides, 12 parts of carvacrol, Ubidecarenone part, 7 parts of 4- methoxyl group coumestrol, 0.06 part of crocin.
The assistant activator the preparation method comprises the following steps:
(1) sodium bicarbonate and aspartic acid are uniformly mixed, are put into reaction kettle, deionized water is added extremely into reaction kettle
Mixed liquor volume reaches the 85% of reaction kettle volume, and reaction kettle is put into 80 DEG C of baking ovens and reacts 4h, natural cooling after reaction
To room temperature；
(2) tea polysaccharide, mountain Cape jasmine glycosides, carvacrol are uniformly mixed, stir 40min under 80r/min revolving speed, is put into -10 DEG C
2h is freezed, is warming up to after room temperature naturally and ubiquinone, 4- methoxyl group coumestrol, crocin is uniformly mixed, mixture weight is added
3 times of deionized water of amount, stirs 20min under 150r/min revolving speed in 36 DEG C of water-baths, stands water-bath 3h after stirring, after standing from
The heart takes supernatant liquor；
(3) solution after the supernatant of above-mentioned steps preparation and step (1) reaction is uniformly mixed, in 120r/min revolving speed
Lower stirring 15min carries out instantaneous sterilizing with pasteurization, the assistant activator is made.
The biological agent is for treating acute urticaria.
Comparative example:
A kind of Chinese medicine composition for treating nettle rash, takes respectively by weight:
Radix saposhnikoviae is 6 parts, rhizoma atractylodis are 9 parts,
The fruit of summer cypress is 4 parts, the root bark of tree peony is 12 parts,
Hilllock chrysanthemum is 10 parts, Herba Lycopodii is 6 parts,
Trigone is 5 parts, southern rattan is 7 parts,
Big winter grass is 11 parts, the fruit of a cubeb litsea tree is 4 parts,
It is mixed after above-mentioned various Chinese medicines are crushed, for the Chinese medicine composition of the treatment nettle rash of preparation.
Clinical 200 patients for suffering from acute urticaria are chosen, 4 groups is divided into, injects the present invention respectively for first 3 groups and implement
Biological agent prepared by example 2, embodiment 3, embodiment 4, per injection 10ml, injection 2 times daily, the 4th group is taken comparative example institute
State Chinese medicine composition.
After treatment 2 days, patient health status is observed, as a result as follows:
Wherein, effective finger symptom completely disappears, and effectively finger symptom is eased, and refers to that symptom does not have any change in vain.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (4)
1. a kind of preparation method for the biological agent having no drug resistance, which comprises the following steps:
(1) Chinese medicine material is uniformly mixed, is put into food steamer and steams 40-50min under the conditions of 60-80 DEG C, 0.3-0.4MPa, steamed
It is sterilized after system using ultraviolet light irradiation, is broken into powder with crusher after sterilization, powder weight 12- is added into powder
15% deionized water is put at -5 DEG C and freezes 3-4h, is warming up to room temperature after freezing naturally, powder is dried；
(2) it is added 12-15 times of powder weight of ethyl alcohol into above-mentioned powder, immersion 2-3h, refluxing extraction 3-4h, centrifugal filtration,
The first filtrate and the first sediment are collected, the first sediment is added to the ethyl alcohol of 8-10 times of its weight, refluxing extraction 1-2h, centrifugation
The second filtrate is collected in filtering, and the first filtrate and the second filtrate are merged, and recycling ethyl alcohol is concentrated under reduced pressure, and primary liquid medicine is made；
(3) primary liquid medicine is uniformly mixed with assistant activator after sterilizing, is continued using heat using autoclaving sterilizing 50min
Sterilization sterilizing 40min is pressed, 50 times of mixed liquor weight of water for injection is added into mixed liquor, is stirred with 1200r/min revolving speed
60-80min, centrifugal filtration after stirring are collected supernatant and are killed the medicinal activated carbon adsorption of supernatant after absorption using bus
Bacterium method is sterilized, and the biological agent is made.
2. the preparation method of the biological agent according to claim 1 having no drug resistance, which is characterized in that the Chinese medicine material
It is made of the raw material of following parts by weight: 10-20 parts of hairyvein agrimony, 5-8 parts of luffa vine, 1-2 parts of Radix Glycyrrhizae, 6-9 parts of Chinese gall, wild chrysanthemum
12-15 parts, 8-10 parts of kuh-seng, 3-5 parts of lobelia chinensis, 15-20 parts of the root of Dahurain angelica, 16-22 parts of purple perilla, 18-25 parts of dandelion, rhizoma acori graminei 7-
10 parts, 10-13 parts of Bunge Corydalis Herb, 8-10 parts of azedarach, 4-6 parts of pomelo peel, 2-5 parts of Rehmannia glutinosa.
3. the preparation method of the biological agent according to claim 1 having no drug resistance, which is characterized in that the assistant activator
It is made of the raw material of following parts by weight: 25-35 parts of tea polysaccharide, 12-15 parts of sodium bicarbonate, 18-26 parts of aspartic acid, mountain Cape jasmine glycosides
12-16 parts, 8-12 parts of carvacrol, 6-10 parts of ubiquinone, 4-7 parts of 4- methoxyl group coumestrol, 0.02-0.06 parts of crocin.
4. the preparation method of the biological agent according to claim 3 having no drug resistance, which is characterized in that the assistant activator
The preparation method comprises the following steps:
(1) sodium bicarbonate and aspartic acid are uniformly mixed, are put into reaction kettle, deionized water is added into reaction kettle to mixing
Liquor capacity reaches the 85% of reaction kettle volume, and reaction kettle is put into 60-80 DEG C of baking oven and reacts 3-4h, natural cooling after reaction
To room temperature；
(2) tea polysaccharide, mountain Cape jasmine glycosides, carvacrol are uniformly mixed, stir 30-40min under 60-80r/min revolving speed, is put into -10
DEG C freezing 1-2h, be warming up to after room temperature naturally and ubiquinone, 4- methoxyl group coumestrol, crocin be uniformly mixed, be added mixing
The deionized water of 2-3 times of object weight stirs 15-20min under 120-150r/min revolving speed in 32-36 DEG C of water-bath, quiet after stirring
Water-bath 2-3h is set, is centrifuged after standing, takes supernatant liquor；
(3) solution after the supernatant of above-mentioned steps preparation and step (1) reaction is uniformly mixed, in 100-120r/min revolving speed
Lower stirring 10-15min carries out instantaneous sterilizing with pasteurization, the assistant activator is made.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110150332A (en) * | 2019-07-01 | 2019-08-23 | 中国农业科学院烟草研究所 | A kind of composition containing carvacrol, fungicide and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006076886A (en) * | 2004-08-12 | 2006-03-23 | Ryoichi Takahashi | Maerchen skin remedy |
| CN101156925A (en) * | 2007-07-06 | 2008-04-09 | 周朝红 | A traditional Chinese medicine preparation for treating children dermatosis |
| CN101249232A (en) * | 2008-03-16 | 2008-08-27 | 李爱英 | Externally used Chinese medicine for curing pruritus dermatopathy relieve itching |
| CN107802800A (en) * | 2017-12-29 | 2018-03-16 | 王中杰 | For treating the Chinese medicine composition of nettle rash |
| CN107929540A (en) * | 2018-01-05 | 2018-04-20 | 张愿 | A kind of external traditional Chinese medicine ointment for treating nettle rash |
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2018
- 2018-09-25 CN CN201811115681.0A patent/CN109106827A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006076886A (en) * | 2004-08-12 | 2006-03-23 | Ryoichi Takahashi | Maerchen skin remedy |
| CN101156925A (en) * | 2007-07-06 | 2008-04-09 | 周朝红 | A traditional Chinese medicine preparation for treating children dermatosis |
| CN101249232A (en) * | 2008-03-16 | 2008-08-27 | 李爱英 | Externally used Chinese medicine for curing pruritus dermatopathy relieve itching |
| CN107802800A (en) * | 2017-12-29 | 2018-03-16 | 王中杰 | For treating the Chinese medicine composition of nettle rash |
| CN107929540A (en) * | 2018-01-05 | 2018-04-20 | 张愿 | A kind of external traditional Chinese medicine ointment for treating nettle rash |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110150332A (en) * | 2019-07-01 | 2019-08-23 | 中国农业科学院烟草研究所 | A kind of composition containing carvacrol, fungicide and its preparation method and application |
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Application publication date: 20190101 |