CN109091587A - A kind of ointment and preparation method thereof for treating burn and scald - Google Patents

A kind of ointment and preparation method thereof for treating burn and scald Download PDF

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CN109091587A
CN109091587A CN201811364092.6A CN201811364092A CN109091587A CN 109091587 A CN109091587 A CN 109091587A CN 201811364092 A CN201811364092 A CN 201811364092A CN 109091587 A CN109091587 A CN 109091587A
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parts
ointment
scald
burn
treating
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王立新
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Abstract

The invention discloses a kind of ointment and preparation method thereof for treating burn and scald, it is described for treat the ointment of burn and scald to include active constituent and ointment base, including active constituent and ointment base, the active constituent is prepared from the following raw materials in parts by weight: 20-50 parts of Siberian elm brak, 10-30 parts of japanese pagodatree bark, 10-20 parts of Huang Shi, 10-20 parts of Rhizoma Chuanxiong, 10-40 parts of calamine, 10-30 parts of calcined gypsum, 10-30 parts of pearl, 5-15 parts of dragon's blood, 5-15 parts of borneol.The preparation method of the ointment includes Siberian elm brak, japanese pagodatree bark, Huang Shi, that medicine block is made in Rhizoma Chuanxiong is spare, the medicine block is ground into calamine, calcined gypsum, pearl, dragon's blood to that medicinal powder is made is spare, the ointment base that the ointment base heating and melting is melted, then medicinal powder and ointment base are added to stirring in the ointment base of thawing, the ointment can be obtained.Its pharmaceutical raw material of ointment of the invention is from a wealth of sources to be easy to get, compatibility is appropriate, analgesic effect is good, it is fast to cure speed.

Description

A kind of ointment and preparation method thereof for treating burn and scald
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of ointment and preparation method thereof for treating burn and scald.
Background technique
Burn and scald, electric injury, sore swell and ache curative, skin injury, the surface of a wound, which fester in daily life, often to be occurred, tight to the state of an illness The patient of weight just easily causes the infection of wound, suppurates, festers, leave permanent if be not treated in time or malpractice Scar, What is more can life-threatening.In terms of stating wound in the treatment at present, the generally existing prescription of the drug clinically applied is former Expect the problem that source is difficult, compatibility is troublesome, analgesic effect is poor, healing rate is slow.
Summary of the invention
For above-mentioned deficiency, the first object of the present invention is to provide that a kind of pharmaceutical raw material is from a wealth of sources to be easy to get, match 5 is appropriate, analgesic effect is good, it is fireballing for treating the ointment of burn and scald to cure.
In order to realize the first purpose of foregoing invention, the present invention adopts the following technical scheme: a kind of for treating burn and scald Ointment, including active constituent and ointment base, the active constituent be prepared from the following raw materials in parts by weight: Siberian elm brak 20-50 parts, 10-30 parts of japanese pagodatree bark, 10-20 parts of Huang Shi, 10-20 parts of Rhizoma Chuanxiong, 10-40 parts of calamine, 10-30 parts of calcined gypsum, treasure 10-30 parts of pearl, 5-15 parts of dragon's blood, 5-15 parts of borneol.
In above-mentioned technical proposal, it is preferable that in the ointment of every 1000 parts by weight, containing 90-250 parts by weight activity at Point.
In above-mentioned technical proposal, it is preferable that the active constituent is prepared from the following raw materials in parts by weight: Siberian elm brak 30 Part, 20 parts of japanese pagodatree bark, 15 parts of Huang Shi, 15 parts of Rhizoma Chuanxiong, 10 parts of calamine, 20 parts of calcined gypsum, 20 parts of pearl, 10 parts of dragon's blood, borneol 5 Part.
In above-mentioned technical proposal, it is preferable that the ointment base is that dimethicone, atoleine, beeswax, glycerol are bright One of glue, vaseline or a variety of mixing.Further preferably, the ointment base is atoleine, beeswax and Fan Shi The mixture of woods, the atoleine, beeswax, vaseline weight ratio be 1:1:8.
It further include the preservative of 0.05-0.1 parts by weight, the anti-corrosion still further preferably in above-mentioned technical proposal Agent is ethyl-para-hydroxybenzoate.
In above-mentioned technical proposal, it is preferable that the ointment further includes preservative, and the preservative is para hydroxybenzene first Acetoacetic ester.
Understand above-mentioned technical proposal of the invention to easily facilitate, below to each raw material of active constituent in the present invention with And control effect and mechanism is further elaborated:
Siberian elm brak: it is sweet, flat, have effects that pain of reducing swelling.
Japanese pagodatree bark: it is sweet, flat, have effects that swelling and pain relieving.
Calamine: it is sweet, flat, there is the effect of hygroscopic antipruritic sore.
Calcined gypsum: it is sweet, pungent, cold, there is the effect of hygroscopic, myogenic, sore, hemostasis.
Pearl: it is sweet, salty, cold, have effects that solve taking poison and growing muscle due, moistening skin and eliminating spot.
Dragon's blood: it is sweet, salty, flat, have effects that myogenic sore.
Borneol: it is pungent, bitter, slightly cold, have effects that clearing away heat to and alleviating pain.
Radix Astragali: sweet, tepor has effects that tonifying Qi and lifting yang, expelling pus and promoting granulation.
Rhizoma Chuanxiong: it is pungent, warm, have effects that blood-activating and qi-promoting.
This product plays swelling and pain relieving using Siberian elm brak, japanese pagodatree bark as monarch drug in a prescription altogether；It is raw with Rhizoma Chuanxiong, Radix Astragali activating microcirculation and removing stasis medicinal, sore Flesh is ministerial drug；Assistant is used altogether for the clearing heat and detoxicating, expelling pus and promoting granulation of auxiliary with calamine, calcined gypsum, pearl, dragon's blood；Borneol has in side There is fragrant analgesic effect.It is altogether clearing heat and detoxicating, expelling pus and promoting granulation function.
The second object of the present invention is to provide above-mentioned for treating the preparation method of the ointment of burn and scald, preparation method letter It is single efficient, it adopts the following technical scheme that
Step 1: raw material Siberian elm brak, japanese pagodatree bark, Radix Astragali, Rhizoma Chuanxiong to be sought according to the parts by weight and is 90%-95% with concentration Alcohol impregnate 48 hours or more, it is multiple to collect extracting solution for refluxing extraction；
Step 2: combined extract recycles ethyl alcohol, after being condensed into medicinal extract, the extract dry is spare at medicine block；
Step 3: raw material calamine, calcined gypsum, pearl, dragon's blood are sought according to the parts by weight, and together with above-mentioned steps two The medicine block obtained, one reinstates equipment ball mill, and that powder is made is spare；
Step 4: will seek raw material borneol according to the parts by weight, and it is standby to dissolve it in obtained borneol alcoholic solution in alcohol With；
Step 5: borneol alcoholic solution made from medicinal powder made from above-mentioned steps three, above-mentioned steps four is added to thawing together The ointment base in, stir evenly can be obtained it is described for treating the ointment of burn and scald.
In above-mentioned preparation method, in above-mentioned steps three, the mesh number of obtained powder is preferably smaller than equal to 120.
In above-mentioned preparation method, in above-mentioned steps four, the borneol is dissolved preferably by the alcohol that concentration is 95%.
In above-mentioned preparation method, in above-mentioned steps five, the temperature of the ointment base of thawing is preferably 88-92 DEG C, to Temperature is stirring evenly after being reduced to 51-55 DEG C.
The present invention obtains following the utility model has the advantages that the raw material sources of ointment for burns and scalds of the invention are extensive compared with prior art It being easy to get, drug effect is clear, and compatibility is appropriate, has effects that clearing heat and detoxicating, expelling pus and promoting granulation, various skin lesions caused by heat toxin are applicable in, It festers suitable for burn, scald, electric injury, sore swell and ache curative, skin injury, the surface of a wound, analgesic effect is good, and it is fast to cure speed；This hair The preparation method of bright ointment for burns and scalds is simple and efficient, and the method that Siberian elm brak, japanese pagodatree bark, Huang Shi, Rhizoma Chuanxiong use alcohol extracting avoids passing The decoction of system method water makes part effective component be destroyed and be generated excessive sediment.
Specific embodiment
By the technology contents of invention are described in detail, construction feature, are reached purpose and efficacy, below in conjunction with embodiment pair Technical solution of the present invention is described in detail.
Embodiment 1
Ointment is made of the raw material of following weight:
Active raw materials:
20 grams of Siberian elm brak
10 grams of japanese pagodatree bark
10 grams of Radix Astragali
10 grams of Rhizoma Chuanxiong
20 grams of calamine
10 grams of calcined gypsum
10 grams of pearl
10 grams of dragon's blood
5 grams of borneol
Preservative raw material: 0.05 gram of ethyl-para-hydroxybenzoate
Ointment base raw material: dimethicone, atoleine, glycerin gelatine, vaseline weight ratio be 1:1:1:7
Active constituent, preservative and ointment base amount to 1000 grams.
The preparation side of ointment is as follows:
1, it weighs raw material: weighing Siberian elm brak, japanese pagodatree bark, Huang Shi, Rhizoma Chuanxiong, calamine, calcined gypsum, treasure according to above-mentioned weight demands Pearl, dragon's blood and preservative ethyl-para-hydroxybenzoate.
2, it is with the volume fraction of 2 times of drug weights by the Siberian elm brak weighed in step 1, japanese pagodatree bark, Huang Shi, Rhizoma Chuanxiong 90% alcohol solution dipping 2 times impregnates 2 days every time, merges leachate refluxing extraction 2 times, and the temperature of refluxing extraction is 80 DEG C of left sides The right side, each 2h, combined extract recycle ethyl alcohol, and extracting solution is concentrated into the 10% of its weight and obtains medicinal extract, take out medicinal extract 50 It is spare that medicine block is dried under the conditions of DEG C.
3, by medicine block ball obtained in the calamine weighed in step 1, calcined gypsum, pearl, dragon's blood and step 2 The medicinal powder that 120 mesh are made in grinding machine is spare.
4, the ethanol solution that the volume fraction of its 1.5 times of weight is 95% is added in the weighed borneol of step 1 to dissolve to obtain ice Piece alcoholic solution is spare.
5, ointment base is configured: by dimethicone, atoleine, glycerin gelatine, vaseline, by the weight of 1:1:1:7 Ratio is heated to melting completely in container jointly, and 90 DEG C of temperature or so are kept for 30 minutes.
6, it configures: taking the ointment base melted in right amount, will be made in ethyl-para-hydroxybenzoate weighed in step 1, step 3 Medicinal powder and step 4 in borneol alcoholic solution obtained be added slowly together in the ointment base of the thawing, temperature by 85 DEG C are down to 50 DEG C or so uniform stirrings, and finally ointment base is added until reaching 1000 grams in supplement, and being evenly stirred until into cream is It can.
7, it dispenses: being dispensed with automatic filling machine.Toothpaste product 1 is made in 40 grams/.
Embodiment 2
Ointment is made of the raw material of following weight:
Active raw materials:
30 grams of Siberian elm brak
20 grams of japanese pagodatree bark
10 grams of Radix Astragali
10 grams of Rhizoma Chuanxiong
20 grams of calamine
20 grams of calcined gypsum
10 grams of pearl
10 grams of dragon's blood
5 grams of borneol
Preservative raw material: 0.8 gram of butyl p-hydroxybenzoate
Ointment base raw material: dimethicone, atoleine, beeswax, glycerin gelatine, vaseline weight ratio are 1:1:1:1:6
Active constituent, preservative and ointment base amount to 1000 grams.
The preparation side of ointment is as follows:
1, it weighs raw material: weighing Siberian elm brak, japanese pagodatree bark, Huang Shi, Rhizoma Chuanxiong, calamine, calcined gypsum, treasure according to above-mentioned weight demands Pearl, dragon's blood and preservative ethyl-para-hydroxybenzoate.
2, it is with the volume fraction of 3 times of drug weights by the Siberian elm brak weighed in step 1, japanese pagodatree bark, Huang Shi, Rhizoma Chuanxiong 95% alcohol solution dipping 2 times impregnates 2 days every time, merges leachate refluxing extraction 2 times, and the temperature of refluxing extraction is 80 DEG C of left sides The right side, each 2h, combined extract recycle ethyl alcohol, and extracting solution is concentrated into the 15% of its weight and obtains medicinal extract, take out medicinal extract 50 It is spare that medicine block is dried under the conditions of DEG C.
3, by medicine block ball obtained in the calamine weighed in step 1, calcined gypsum, pearl, dragon's blood and step 2 The medicinal powder that 120 mesh are made in grinding machine is spare.
4, the ethanol solution that the volume fraction of its 1.5 times of weight is 95% is added in the weighed borneol of step 1 to dissolve to obtain ice Piece alcoholic solution is spare.
5, ointment base is configured: specifically: configuration ointment base: dimethicone, atoleine, beeswax, glycerol is bright Glue, all scholars are heated to melting completely in container jointly according to the weight ratio of 1:1:1:1:6, and 90 DEG C of temperature or so are kept for 30 points Clock.Wherein, preparing raw material beeswax used by ointment base is that will be made after the purification of commercially available beeswax, specifically: it will be commercially available Beeswax keeps the temperature about 30 minutes for 90 ± 2 DEG C after vessel in heating melts it, has taken supernatant liquid filtering both with 4-8 layers of hospital gauze ?.
6, it configures: taking the ointment base melted in right amount, it will be obtained in ethyl-para-hydroxybenzoate weighed in step 1, step 3 Borneol alcoholic solution obtained is added slowly together in the ointment base of the thawing in medicinal powder and step 4, and temperature is by 85 DEG C 50 DEG C or so uniform stirrings are down to, finally ointment base is added until reaching 1000 grams in supplement, is evenly stirred until into cream.
7, it dispenses: being dispensed with automatic filling machine.Toothpaste product 2 is made in 40 grams/.
Embodiment 3
Ointment is made of the raw material of following weight:
Active raw materials:
30 grams of Siberian elm brak
20 grams of japanese pagodatree bark
15 grams of Radix Astragali
15 grams of Rhizoma Chuanxiong
10 grams of calamine
20 grams of calcined gypsum
20 grams of pearl
10 grams of dragon's blood
5 grams of borneol
Preservative raw material: 1 gram of ethyl-para-hydroxybenzoate
Ointment base raw material: atoleine, beeswax, vaseline weight ratio be 1:1:8
Active constituent, preservative and ointment base amount to 1000 grams.
Ointment is prepared by the following method, and specific step is as follows:
1, it weighs raw material: weighing Siberian elm brak, japanese pagodatree bark, Huang Shi, Rhizoma Chuanxiong, calamine, calcined gypsum, treasure according to above-mentioned weight demands Pearl, dragon's blood and preservative ethyl-para-hydroxybenzoate.
2, the alcohol (drug of the medicine material Siberian elm brak of above-mentioned g number, japanese pagodatree bark, Radix Astragali, Rhizoma Chuanxiong concentration 90%-95% are taken 2-4 times of weight, grams per milliliter) impregnate 48 hours or more, refluxing extraction 2 hours, 80 ± 2 DEG C of reflux temperature were collected extracting solution leaching Liquid out, 2 times.
3, combined extract recycles ethyl alcohol, after being condensed into cream, takes out, 52 ± 2 DEG C of low temperature are dried to medicine block.The rate of recovery is The 10%-15% of drug weight.
4, the dry medicine block of the medicine material drug calamine of above-mentioned g number, calcined gypsum, pearl, dragon's blood and extract is taken, with setting Most fine powder is made in standby ball mill, is all sieved by 120 mesh medicines, and it is spare that medicinal powder is made.
5, prepared by matrix: atoleine, beeswax, vaseline are heated in container jointly by the weight ratio of 1:1:8 Melt completely, 90 ± 2 DEG C of temperature are kept for 30 minutes.?.Beeswax purification: by commercially available beeswax after vessel in heating melts it 90 ± 2 DEG C keep the temperature about 30 minutes, take supernatant liquid filtering both to obtain with 4-8 layers of hospital gauze.
6, it prepares: taking borneol to be made it dissolve with concentration for 95% alcohol (1:1-1.5 weight/milliliter) spare.It takes above-mentioned spare The ethyl-para-hydroxybenzoate (preservative) of medicinal powder, borneol alcoholic solution and 1g is slowly added in the matrix melted in right amount, temperature It is down to 53 ± 2 DEG C by 90 °C to stir evenly, finally matrix is added until reaching 1000 grams in supplement, is evenly stirred until into cream.
7, it dispenses: being dispensed with automatic filling machine.Toothpaste product 3 is made in 40 grams/.
Embodiment 4
Ointment is made of the raw material of following weight:
Active raw materials:
50 grams of Siberian elm brak
30 grams of japanese pagodatree bark
20 grams of Radix Astragali
20 grams of Rhizoma Chuanxiong
40 grams of calamine
30 grams of calcined gypsum
30 grams of pearl
15 grams of dragon's blood
15 grams of borneol
Preservative raw material: 1 gram of ethyl-para-hydroxybenzoate
Ointment base raw material: atoleine, beeswax, vaseline weight ratio be 1:1:8
Active constituent, preservative and ointment base amount to 1000 grams.
Ointment is prepared by the following method, and specific step is as follows:
1, it weighs raw material: weighing Siberian elm brak, japanese pagodatree bark, Huang Shi, Rhizoma Chuanxiong, calamine, calcined gypsum, treasure according to above-mentioned weight demands Pearl, dragon's blood and preservative ethyl-para-hydroxybenzoate.
2, take the medicine material Siberian elm brak of above-mentioned g number, japanese pagodatree bark, Radix Astragali, Rhizoma Chuanxiong concentration 95% alcohol (drug weight 2-4 times, grams per milliliter) impregnate 48 hours or more, refluxing extraction 2 hours, 80 ± 2 DEG C of reflux temperature were collected extracting solution leachate, 2 times.
3, combined extract recycles ethyl alcohol, after being condensed into cream, takes out, 52 ± 2 DEG C of low temperature are dried to medicine block.The rate of recovery is The 10%-15% of drug weight.
4, the dry medicine block of the medicine material drug calamine of above-mentioned g number, calcined gypsum, pearl, dragon's blood and extract is taken, with setting Most fine powder is made in standby ball mill, is all sieved by 120 mesh medicines, and it is spare that medicinal powder is made.
5, prepared by matrix: atoleine, beeswax, vaseline are heated in container jointly by the weight ratio of 1:1:8 Melt completely, 90 ± 2 DEG C of temperature are kept for 30 minutes.?.Beeswax purification: by commercially available beeswax after vessel in heating melts it 90 ± 2 DEG C keep the temperature about 30 minutes, take supernatant liquid filtering both to obtain with 4-8 layers of hospital gauze.
6, it prepares: taking borneol to be made it dissolve with concentration for 95% alcohol (1:1-1.5 weight/milliliter) spare.It takes above-mentioned spare The ethyl-para-hydroxybenzoate (preservative) of medicinal powder, borneol alcoholic solution and 1g is slowly added in the matrix melted in right amount, temperature It is down to 53 ± 2 DEG C by 90 °C to stir evenly, finally matrix is added until reaching 1000 grams in supplement, is evenly stirred until into cream.
7, it dispenses: being dispensed with automatic filling machine.Toothpaste product 4 is made in 40 grams/.
Toothpaste product 1-4 major function and usage and dosage in above-described embodiment 1-4
1. major function: clearing heat and detoxicating expelling pus and promoting granulation.It is applicable in various skin lesions caused by heat toxin.For burning, scalding, electric injury, sore Ulcer swelling and pain, skin injury, the surface of a wound fester.
2. usage and dosage: external application.After cleaning the surface of a wound, the gauze for being coated with ointment is laid on the surface of a wound, with sterile cotton pad packet It pricks, dressing on the one 1 time.Every 1% body surface area medication about 3g, 5~8 as a treatment course.
Treatment effectiveness evaluation
Using above-mentioned obtained toothpaste product 1-4, in certain city, burn cosmetic surgery hospital has carried out clinical burn and scald treatment.
The clinical observation of specific case: in May, 2014 in May, 2017, outpatient service burned patient 1500 is accepted for medical treatment altogether Example, whereinDegree burned patient 450, shallowlyDegree burned patient 532, it is deepDegree burned patient 518.
Treatment method: being randomly provided to patient for toothpaste product 1-4, specially uniformly applies this treatment ointment for burns and scalds Smear the daily dressing 1 time on empyrosis wound surface.
Clinical efficacy statistics is as follows:
Spend burned patient: after medication in 3 days, 435 healings, remaining improvement is all cured, wound healing after medication in 5 days Afterwards without scar, in medication therapeutic process, pain can be released within 10 minutes after medication, quickly promote muscle, skin growth, skin Diffusate is few, can close wound in short term, and wound is not glued in dressing, pain is small.
ShallowlySpend burned patient: after medication in 10 days, 495 healings, remaining improvement is all cured after medication in 15 days, Substantially without scar after wound healing, in medication therapeutic process, pain can be released within 15 minutes after medication, quickly promote muscle, Skin growth, skin diffusate is few, can close wound in short term, and wound is not glued in dressing, pain is small.
It is deepSpend burned patient: after medication in 18 days, 480 healings, remaining improvement is all cured after medication in 25 days, Without obvious scar after wound healing, in medication therapeutic process, pain can be released within 20 minutes after medication, quickly promote muscle, Skin growth, skin diffusate is few, can close wound in short term, and wound is not glued in dressing, pain is small.
Typical case:
On January 18th, 2016, patient Huang, male, 50 years old, scalding thigh, after diagnosing forDegree burn, using the present invention The ointment of embodiment 5 is treated, and is fully recovered within 3 days, without scar after wound healing, in medication therapeutic process, 10 minutes after medication Pain can be released, muscle, skin growth are quickly promote, skin diffusate is few, can close wound, and the not viscous wound of dressing in short term Mouthful, pain is small.
On 2 6th, 2016, patient Liu, male, 52 years old, scalding thigh, after diagnosing forDegree scald, using market Upper common jingwanhong soft plaster ointment for scald is treated, and is fully recovered within 6 days, without scar, in medication therapeutic process, 2 days after wound healing Pain relief afterwards, the time is longer, and wound healing is slow, and skin diffusate is more, hardly possible cleaning, and dressing is more painful.
On 2 31st, 2017, patient's Mr. Lin, female, 30 years old, by oil scald forearm, after diagnosing forDegree burn, using this hair The ointment of bright embodiment 5 is treated, and is fully recovered within 6 days, without scar after wound healing, in medication therapeutic process, 15 points after medication Clock can release pain, quickly promote muscle, skin growth, and skin diffusate is few, can close wound in short term, and dressing is not glued Wound, pain are small.
On March 5th, 2017, patient Zhang, female, 28 years old, by oil scald forearm, after diagnosing forDegree burn, using market Upper common jingwanhong soft plaster ointment for scald is treated, and is fully recovered within 15 days, without scar after wound healing, in medication therapeutic process, and wound Mouth healing is slow, and skin diffusate is more, hardly possible cleaning, and dressing is more painful.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, the present invention Claimed range is delineated by the appended claims, the specification and equivalents thereof from the appended claims.

Claims (10)

1. a kind of for treating the ointment of burn and scald, including active constituent and ointment base, which is characterized in that the described activity at Divide and be prepared from the following raw materials in parts by weight: 20-50 parts of Siberian elm brak, 10-30 parts of japanese pagodatree bark, 10-20 parts of Huang Shi, Rhizoma Chuanxiong 10-20 Part, 10-40 parts of calamine, 10-30 parts of calcined gypsum, 10-30 parts of pearl, 5-15 parts of dragon's blood, 5-15 parts of borneol.
2. according to claim 1 for treating the ointment of burn and scald, which is characterized in that the ointment of every 1000 parts by weight In, the active constituent containing 90-250 parts by weight.
3. according to claim 1 or 2 for treating the ointment of burn and scald, which is characterized in that the active constituent by The raw material of following parts by weight is made: 30 parts of Siberian elm brak, 15 parts of Huang Shi, 15 parts of Rhizoma Chuanxiong, 10 parts of calamine, is forged 20 parts of japanese pagodatree bark 20 parts of gypsum, 20 parts of pearl, 10 parts of dragon's blood, 5 parts of borneol.
4. according to claim 1 or 2 for treating the ointment of burn and scald, which is characterized in that the ointment base is One of dimethicone, atoleine, beeswax, glycerin gelatine, vaseline or a variety of mixing.
5. according to claim 4 for treating the ointment of burn and scald, which is characterized in that the ointment base is liquid The mixture of paraffin, beeswax and vaseline, the atoleine, beeswax, vaseline weight ratio be 1:1:8.
6. according to claim 5 for treating the ointment of burn and scald, which is characterized in that the ointment further includes anti-corrosion Agent, the preservative are ethyl-para-hydroxybenzoate.
7. a kind of as described in claim 1 for treating the preparation method of the ointment of burn and scald, which is characterized in that including as follows Step:
Step 1: raw material Siberian elm brak, japanese pagodatree bark, Radix Astragali, Rhizoma Chuanxiong to be sought according to the parts by weight and is 90%-95% with concentration Alcohol impregnate 48 hours or more, it is multiple to collect extracting solution for refluxing extraction；
Step 2: combined extract recycles ethyl alcohol, after being condensed into medicinal extract, the extract dry is spare at medicine block；
Step 3: raw material calamine, calcined gypsum, pearl, dragon's blood are sought according to the parts by weight, and together with above-mentioned steps two The medicine block obtained, one reinstates equipment ball mill, and that powder is made is spare；
Step 4: will seek raw material borneol according to the parts by weight, and it is standby to dissolve it in obtained borneol alcoholic solution in alcohol With；
Step 5: borneol alcoholic solution made from medicinal powder made from above-mentioned steps three, above-mentioned steps four is added to thawing together The ointment base in, stir evenly can be obtained it is described for treating the ointment of burn and scald.
8. according to claim 7 for treating the preparation method of the ointment of burn and scald, which is characterized in that above-mentioned steps three In, the mesh number of obtained powder is less than or equal to 120.
9. according to claim 7 for treating the preparation method of the ointment of burn and scald, which is characterized in that above-mentioned steps four In, the borneol is dissolved using the alcohol that concentration is 95%.
10. according to claim 7 for treating the preparation method of the ointment of burn and scald, which is characterized in that above-mentioned steps In five, the temperature of the ointment base of thawing is 88-92 DEG C, is being stirred evenly after temperature is reduced to 51-55 DEG C.
CN201811364092.6A 2018-11-16 2018-11-16 A kind of ointment and preparation method thereof for treating burn and scald Pending CN109091587A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1935159A (en) * 2006-09-18 2007-03-28 吴方忠 Chinese medicine composition for treating burn, empyrosis and bodysurface ulcer and its preparing method
CN101129678A (en) * 2007-09-05 2008-02-27 杨丕良 Externally used formulated product for treating empyrosis and method of preparing the same
CN101607014A (en) * 2008-06-18 2009-12-23 朱春燕 Ointment of a kind of promoting tissue regeneration and ulcer healing and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1935159A (en) * 2006-09-18 2007-03-28 吴方忠 Chinese medicine composition for treating burn, empyrosis and bodysurface ulcer and its preparing method
CN101129678A (en) * 2007-09-05 2008-02-27 杨丕良 Externally used formulated product for treating empyrosis and method of preparing the same
CN101607014A (en) * 2008-06-18 2009-12-23 朱春燕 Ointment of a kind of promoting tissue regeneration and ulcer healing and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
南京中医药大学编著: "《中药大辞典（第二版）》", 31 March 2006, 上海科学技术出版社 *
李定航等: "有价值的白榆树", 《科普田园》 *
李潇彦: "《中华养生百科 第2卷》", 30 April 2009, 吉林大学出版社 *
鄢海燕等主编: "《药剂学》", 31 January 2018, 江苏凤凰科学技术出版社 *

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