CN109085193A - A kind of the proton application system and its operating method of automatic quickly detection boron concentration - Google Patents
A kind of the proton application system and its operating method of automatic quickly detection boron concentration Download PDFInfo
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- CN109085193A CN109085193A CN201811023813.7A CN201811023813A CN109085193A CN 109085193 A CN109085193 A CN 109085193A CN 201811023813 A CN201811023813 A CN 201811023813A CN 109085193 A CN109085193 A CN 109085193A
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- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title claims abstract description 300
- 229910052796 boron Inorganic materials 0.000 title claims abstract description 300
- 238000001514 detection method Methods 0.000 title claims abstract description 169
- 238000011017 operating method Methods 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 49
- 238000012360 testing method Methods 0.000 claims abstract description 46
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 42
- 241001637516 Polygonia c-album Species 0.000 claims abstract description 35
- 230000004992 fission Effects 0.000 claims abstract description 35
- 238000005070 sampling Methods 0.000 claims abstract description 17
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- 230000001105 regulatory effect Effects 0.000 claims description 6
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- 238000012216 screening Methods 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 4
- 239000000523 sample Substances 0.000 description 174
- 238000010586 diagram Methods 0.000 description 12
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000009616 inductively coupled plasma Methods 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 4
- 229910052744 lithium Inorganic materials 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000001678 irradiating effect Effects 0.000 description 3
- 239000013078 crystal Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
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- 239000002245 particle Substances 0.000 description 2
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- 230000000149 penetrating effect Effects 0.000 description 2
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- ZOXJGFHDIHLPTG-BJUDXGSMSA-N Boron-10 Chemical compound [10B] ZOXJGFHDIHLPTG-BJUDXGSMSA-N 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
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- 229910052790 beryllium Inorganic materials 0.000 description 1
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
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- 239000004744 fabric Substances 0.000 description 1
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- 238000013467 fragmentation Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
- G01N23/225—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion
- G01N23/2255—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion using incident ion beams, e.g. proton beams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
Abstract
The invention belongs to treatment technology fields, a kind of proton application system of automatic quickly detection boron concentration, including low energy linear accelerator system are disclosed, for generating proton beam and accelerating proton beam energy；The automatic rapid detection system of boron-containing sample boron concentration, for the automatic quick boron concentration quantitative measurement of batch boron-containing sample, including detection span line, neutron-exposure facility, boron-containing sample automatic sampling apparatus, prompt fission gammas detection and analysis device, line capturing device, detecting and controlling system.Proton application system of the invention is not only able to achieve the boron concentration in automatic, quick detection boron-containing sample, but also can connect neutron capture therapy system and/or radionuclide production system simultaneously, and apparatus function is strong, integrated level is high.Meanwhile the present invention also provides a kind of quick boron concentration detection method of boron-containing sample, the efficiency of a large amount of boron-containing sample boron Concentration Testings is effectively increased, and significantly reduce the cost of such detection.
Description
Technical field
The present invention relates to radiation therapy technology field more particularly to a kind of proton application systems of automatic quickly detection boron concentration
System.
Background technique
Boron neutron capture therapy (Boron Neutron Capture Therapy, BNCT) is a kind of " medical instruments combination ", peace
The better biological targeting binary radiotherapy mode of full property, with the excellent of the means such as radiotherapy, chemotherapy, heavy particle therapy from principle
Point is most hopeful to realize the wonderful dream that the mankind eradicate tumour.BNCT treatment will be first by that will have the nontoxic of close tumor tissues
Take boron infusion of medicine blood of human body, it is multi-direction suitable using epithermal neutron wait take boron (boron -10) drug-rich after tumor tissues
Shape irradiates tumor locus, and -10 nucleic of boron in neutron and cancer cell meets and occurs nuclear reaction, the alpha particle of releasing and
- 7 particle of lithium has very strong lethality to cell, and fragmentation effect is higher than existing X-ray, gamma ray radiotherapy and proton and puts
It treats.The side effect of BNCT is smaller, and with taking further increasing for boron drug parent's tumor effect, BNCT normal tissue
Damage will further decrease.The expansion in extensive range, and having can treat proton, heavy particle therapy not of the tumour indication of BNCT
Dissipate the tumor cases that recur again after type malignant tumour or treatment, such as in glioblastoma multiforme (the pernicious cancer of the brain), multiple
Hair property head and neck cancer, maligna element cutaneum carcinoma, metastatic liver cancer etc., therapeutic effect is significantly better than existing treatment technology.
In BNCT therapeutic process, during the boron-doping infusion of drug that patient receives before irradiation, certain interval of time is needed to acquire
Blood sample of patient, the quantitative measurment of boron concentration in promoting circulation of blood sample of going forward side by side.At present clinically, inductively coupled plasma body spectrum is generallyd use
The boron concentration that instrument (ICP-AES, OES, MS) carries out boron-containing sample quickly detects；For arranging the BNCT of a BNCT treatment system
Medical centre can satisfy boron concentration quantitative measurement demand using ICP spectrometer.The large size city population of China is huge, right
It, can be by arranging several or even tens of BNCT equipment, the annual people for treating patient in building the metropolitan future center BNCT in
Number is increased to tens of thousands of people, and by intensive management and operation, treatment cost is greatly reduced.Such center BNCT, is being treated
It needs to carry out large batch of boracic blood sample quick boron concentration quantitative measurement in the process, it is existing that boracic blood is carried out using ICP spectrometer
The method of sample boron Concentration Testing is not to be able to satisfy detection demand.Reason mainly has: 1) an ICP spectrometer while can only detect one
A boracic blood sample, and need several minutes of times；The above-mentioned center BNCT just needs to configure more ICP spectrometers, while need to configure more people
Detection device is operated, cost of investment is huge, testing cost is high；2) detection process is mainly by manpower, using manual operations, effect
Rate is low, error-prone, and this detection method cannot be transformed into the detection operation of automation, pipeline mode.
Based on the above situation, we it is necessary to design it is a kind of can be realized quickly detection boracic blood sample detection device.
Summary of the invention
The present invention is directed to solve at least some of the technical problems in related technologies.
It is an object of the invention to a kind of proton application system of automatic quickly detection boron concentration, be not only able to achieve it is automatic,
The quickly boron concentration in detection boron-containing sample, but also neutron capture therapy system and/or radionuclide can be connected simultaneously
Production system, apparatus function is strong, integrated level is high.
Another object of the present invention is to provide a kind of operation sides of the proton application system of automatic quickly detection boron concentration
Method, effectively increases the efficiency of a large amount of boron-containing sample boron Concentration Testings, and significantly reduces the cost of such detection.
To achieve this purpose, the present invention adopts the following technical scheme:
A kind of proton application system of automatic quickly detection boron concentration, comprising:
Low energy linear accelerator system, for generating proton beam and accelerating proton beam energy；
The automatic rapid detection system of boron-containing sample boron concentration, the automatic quick boron concentration quantitative for batch boron-containing sample are surveyed
Amount；Device, line are tested and analyzed including detection span line, neutron-exposure facility, boron-containing sample automatic sampling apparatus, prompt fission gammas
Capturing device, detecting and controlling system；The detection span line is connect with the low energy linear accelerator system, the neutron exposure
Device is connect with the detection span line, the neutron-exposure facility, boron-containing sample automatic sampling apparatus, prompt fission gammas's detection point
Analysis apparatus is connect with the detecting and controlling system electric signal.
Specifically, the proton beam that the detection span line can generate low energy linear accelerator system is adjusted,
Proton beam through overregulating enters the neutron-exposure facility and is converted into neutron beam, and the boron-containing sample automatic sampling apparatus will
Boron-containing sample, which is sent to, matches position with the neutron-exposure facility to receive neutron beam irradiation, and neutron beam irradiates boron-containing sample
Gamma ray can be released, the prompt fission gammas, which tests and analyzes device, can detecte the signal of generated gamma ray, and lead to
Corresponding boron concentration is obtained after crossing analysis, remaining neutron ray can be absorbed for the line capturing device or other impurities are penetrated
Line, with ensure facility using safe.
Preferably, the neutron-exposure facility, including beam channel, expand section, target assembly, neutron beam regulating device, standard
Stretched, line gate, irradiation unit radiation shield.
Preferably, the boron-containing sample automatic sampling apparatus, including sample supporting part, sample transport unit, driving mechanism.
Preferably, the prompt fission gammas tests and analyzes device, including radiation detection portion, signal processing part, detection device spoke
Penetrate shield, calculation part.
As a kind of perferred technical scheme, the proton application system of the automatic quickly detection boron concentration further include:
Line switching system, for switching on proton beam in different application systems；
Neutron capture therapy system, for treating the tumor patient for meeting BNCT treatment screening condition；
And/or radionuclide production system, it produces and extracts for radionuclide.
Specifically, automatically quick with boron sample boron concentration respectively by line switching system when low energy linear accelerator system
Detection system is connected with neutron capture therapy system, and proton application system of the invention both can be carried out the concentration inspection of boron sample
It surveys, and can be carried out BNCT treatment；When low energy linear accelerator system by line switching system respectively with boron sample boron concentration from
Dynamic rapid detection system is connected with radionuclide production system, and proton application system of the invention both can be carried out boron sample
Concentration Testing, and can be carried out radionuclide production and extract；When low energy linear accelerator system passes through line switching system point
It is not connected with the automatic rapid detection system of boron sample boron concentration, neutron capture therapy system and radionuclide production system,
Proton application system of the invention not only can be carried out the Concentration Testing of boron sample, but also can be carried out BNCT treatment, moreover it is possible to carry out radioactivity
Nucleic production and extraction.
A kind of operating method of the proton application system of automatic quickly detection boron concentration, comprising the following steps:
S100: neutron beam quality parameter measurement；
S200: the standard boron-containing sample of known boron concentration is detected；
S300: calibration prompt fission gammas tests and analyzes device；
S400: the boron-containing sample to be tested of unknown boron concentration is detected；
S500: obtaining the boron concentration information of boron-containing sample to be measured, and repeat step S400, handles next to be measured contain
Boron sample, until the detection of all samples to be tested finishes.
Preferably, in step S200: in the standard boron-containing sample for detecting known boron concentration, comprising:
S210: detecting and controlling system is by the line closing gate of neutron-exposure facility；
S220: using boron-containing sample automatic sampling apparatus, and the standard boron-containing sample of boron concentration known to portion is sent to
At the line gate port of sub- irradiation unit；
S230: detecting and controlling system opens the line gate of neutron-exposure facility；
S240: neutron beam irradiates the standard boron-containing sample of the known boron concentration, and obtains qualified gamma spectra or arrive
Up to the detection time limit.
Preferably, in step S300: calibration prompt fission gammas tests and analyzes in device, comprising:
S310: the detection parameters for testing and analyzing device calculation part to prompt fission gammas initialize；
S320: prompt fission gammas tests and analyzes the prompt gamma ray that device receives neutron and nuclear reaction releasing occurs for sample,
It obtains qualified gamma spectra or reaches the detection time limit, detecting and controlling system is by the line closing gate of neutron-exposure facility；
S330: prompt fission gammas tests and analyzes device and uses the detection signal letter of the representative of the acquisition standard boron sample boron concentration
Boron concentration information known to breath and the standard boron sample tests and analyzes device to prompt fission gammas and carries out scale.
As a kind of perferred technical scheme, in step S100: before the measurement of neutron beam quality parameter, further includes:
Proton beam is switched into the automatic rapid detection system of boron-containing sample boron concentration using line switching system.
As a kind of perferred technical scheme, in S500: obtaining the boron concentration information of boron-containing sample to be measured, and repeat
Step S400 handles next boron-containing sample to be measured and further comprises the steps of: until all boron-containing samples to be measured are disposed
Proton beam is switched into neutron capture therapy system using line switching system, carries out BNCT treatment.
As a kind of perferred technical scheme, in step S500: obtaining the boron concentration information of boron-containing sample to be measured, and repeat
Step S400 is executed, next boron-containing sample to be measured is handled, until all boron-containing samples to be measured are disposed, further includes:
Proton beam is switched into radionuclide production system using line switching system, carries out radionuclide production
And it extracts.
The invention has the benefit that
The present invention provides a kind of proton application systems of automatic quickly detection boron concentration, on the one hand, the present invention can be real
Now automatic, quick, mass detects boron-containing sample, and detection time is short, testing result precision is high；On the other hand, of the invention
The proton application system of automatic quickly detection boron concentration can be with neutron capture therapy system and/or radionuclide production system
It is connected, apparatus function is strong, integrated level is high, it can be achieved that tumor patient boron neutron capture therapy, Short-lived radionuclide production
With extraction and the automation of boron-containing sample boron concentration, the quick detection of pipeline mode, neutron capture therapy treatment is effectively improved
The performance and economy of tumour system reduce the overall cost expense of neutron capture therapy treatment neoplastic process.
Detailed description of the invention
Figure 1A is the structural schematic diagram of the embodiment of the present invention one；
Figure 1B is the structural schematic diagram of the embodiment of the present invention one；
Fig. 1 C is the structural schematic diagram of the embodiment of the present invention one；
Fig. 2 is the structural schematic diagram of the embodiment of the present invention two；
Fig. 3 is the structural schematic diagram of the embodiment of the present invention three；
Fig. 4 is the structural schematic diagram of the embodiment of the present invention four；
Fig. 5 A is the flow diagram of the embodiment of the present invention five；
Fig. 5 B is the flow diagram of the embodiment of the present invention five；
Fig. 5 C is the flow diagram of the embodiment of the present invention five；
Fig. 5 D is the flow diagram of the embodiment of the present invention five；
Fig. 5 E is the flow diagram of the embodiment of the present invention five.
Wherein, low energy linear accelerator system 100；Line switching system 200；Boron-containing sample boron concentration quickly detects automatically
System 300, detects span line 301, neutron-exposure facility 302, and beam channel 3021 expands section 3022, target assembly 3023, neutron
Beam regulating device 3024 collimates body 3025, coniform collimation body 30251, cylindric collimation body 30252, line gate 3026, photograph
Injection device radiation shield 3027, boron-containing sample automatic sampling apparatus 303, sample supporting part 3031, sample transport unit 3032 are driven
Motivation structure 3033, prompt fission gammas test and analyze device 304, radiation detection portion 3041, signal processing part 3042, detection device radiation
Shield 3043, calculation part 3044, line capturing device 305, detecting and controlling system 306；Neutron capture therapy system 400；It puts
Penetrating property nucleic production system 500.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention rather than limiting the invention.It also should be noted that in order to just
Only the parts related to the present invention are shown in description, attached drawing rather than entire infrastructure.
In the related art, the method for boron neutron capture therapy tumour is as a kind of current newest radiotherapy,
Through showing preferable therapeutic effect during killing cancer cell.But in order to guarantee the effect for the treatment of, in irradiation treatment
Preceding necessary certain interval of time acquires blood sample of patient, and determines the boron concentration in blood sample, to formulate suitable treatment plan.And
The prior art cannot achieve batch detection for the detection of the boron concentration in blood sample, and need to be equipped with additional detection device,
The input cost for increasing equipment, delays the Case treatment time, and therefore, the embodiment of the invention provides a kind of automatic quickly detection boron
The proton application system of concentration, for improving detection efficiency and reducing the input cost of equipment, specific structure and application method are such as
Under:
Embodiment one:
As shown in Figure 1A, a kind of proton application system of automatic quickly detection boron concentration, comprising: low energy linear accelerator system
System 100, the automatic rapid detection system 300 of boron-containing sample boron concentration.
Since the gamma ray that can generate wink hair when neutron capture nuclear reaction, and detection device occur for neutron beam and boron element
The concentration of detectable signal and -10 element of boron to generated gamma ray is in certain quantitative relation, therefore, by detecting sample
The information for the gamma ray that product generate, and by conversion, the boron concentration of you can get it sample to be tested.Meanwhile the generation of neutron beam
It needs to be beaten with the proton beam of high-speed cruising and nuclear reaction occurs and obtains on certain target.
Low energy linear accelerator system 100 can produce proton beam and accelerate proton beam energies, generally by proton beam energy
Amount accelerates between 3.5-20MeV, provides stable proton beam for the automatic rapid detection system 300 of boron-containing sample boron concentration.
The automatic rapid detection system 300 of boron-containing sample boron concentration, the automatic quick boron concentration for batch boron-containing sample are fixed
Measurement.As shown in Figure 1B, including detection span line 301, neutron-exposure facility 302, boron-containing sample automatic sampling apparatus 303,
Prompt fission gammas tests and analyzes device 304, line capturing device 305, detecting and controlling system 306.Neutron-exposure facility 302, boracic
Sample automatic sampling apparatus 303, prompt fission gammas test and analyze device 304 and connect with 306 electric signal of detecting and controlling system.
Span line 301 is detected, is connect with low energy linear accelerator system 100.
The proton beam that detection span line 301 can generate low energy linear accelerator system 100 is adjusted, so that matter
Beamlet stream meets the requirement of detection application, meets in detection application requirement even if proton beam can generate after beating on related target
Beamlet.
Neutron-exposure facility 302 is connect with detection span line 301.Including beam channel 3021, expand section 3022, target dress
Set 3023, neutron beam regulating device 3024, collimation body 3025, line gate 3026, irradiation unit radiation shield 3027.
Beam channel 3021 in neutron-exposure facility 302 expands section 3022, target assembly 3023, neutron beam regulating device
3024, it collimates body 3025, line gate 3026 to be sequentially connected, beam channel 3021 expands section 3022 and will can pass after testing
The proton beam of defeated section 301 adjusting guides to target location, and beats proton beam to generate neutron beam on target, and neutron beam adjusts dress
The neutron beam of 3024 pairs of generations is set into overregulating, the neutron beams for collimating 3025 pairs of body generations collimate, and neutron beam is from beam later
It is projected at stream gate 3026 to irradiate the sample of test, irradiation unit radiation shield 3027 is enclosed in neutron-exposure facility 302
Periphery can mask the other impurities ray or harm ray generated when target practice, to guarantee the accuracy of detection and using peace
Entirely.
Target assembly 3023 includes target, target supporting body, cooling system；The material of target is selected from solid metal lithium, liquid
Lithium metal, the compound of lithium, in metallic beryllium any one or combinations thereof.
Collimating body 3025 includes coniform collimation body 30251 and cylindric collimation body 30252, to guarantee to reach better
Collimating effect.
Neutron beam regulating device 3024, including neutron degradation body, neutron relfector, gamma ray filtering body.
Boron-containing sample automatic sampling apparatus 303, including sample supporting part 3031, sample transport unit 3032, driving mechanism
3033。
Sample supporting part 3031 is to place the container containing sample to be tested, is evenly arranged multiple samples in sample transport unit 3032
Different sample supporting parts 3031 are sent to neutron exposure dress by way of circulation by product supporting part 3031, sample transport unit 3032
It sets at 302 3026 port of line gate, to receive neutron beam irradiation and test and analyze, driving mechanism 3033 can drive sample
The movement of transport unit 3032, instructs based on the received, and driving mechanism 3033 drives sample transport unit 3032 by associated sample
It is sent to progress neutron beam irradiation at 3026 port of line gate, is removed this sample after the completion of detection, then will be next to be checked
Sample is sent at 3026 port of line gate to receive neutron beam irradiation and test and analyze.
Current sample to be tested is sent to the line lock of neutron-exposure facility 302 by boron-containing sample automatic sampling apparatus 303
Receive neutron beam irradiation at 3026 ports of door, prompt fission gammas tests and analyzes the wink that device 304 receives and analyzes neutron exposure generation
Gamma ray is sent out, in the present embodiment, prompt fission gammas tests and analyzes device 304 and arranges along neutron beam beam line vertical direction,
The discarded line for not being irradiated to sample passes through detection zone collected by line capturing device 305 and accommodates.
Prompt fission gammas tests and analyzes device 304, including radiation detection portion 3041, signal processing part 3042, detection device spoke
Penetrate shield 3043, calculation part 3044.
Gamma ray after collimation can be converted to photosignal by radiation detection portion 3041, and be put to photosignal
Greatly.Including crystal detection, signal collection and enlarging section, crystal detection, signal collection and enlarging section are sequentially connected, and are arranged in detection
Inside device radiation shield 3043.
It is further improved as of the invention, in the present embodiment, as shown in Figure 1 C, the quantity in radiation detection portion 3041 is double
Number, is arranged, in a symmetrical manner to guarantee more effectively to detect gamma ray.
Signal processing part 3042 can digitize the photosignal of detection conversion, and generate and incident gamma ray
The corresponding multiple tracks gamma-spectrometric data of energy.
Specifically, passing through the asymmetrical arrangement in radiation detection portion 3041, the anticoincidence line of binding signal processing unit 3042
Road can efficiently screen and remove noise gammaphoton.Specifically, can be reacted with boron when neutron beam is irradiated and generate gal
Horse photon, usually energy are the gammaphoton of 478keV, are the gammaphoton signals for needing to detect, but detecting in addition to this
Neutron beam can also generate gammaphoton with other substance reactions in journey, and as electron-positron pair annihilation reaction is released, energy is
511keV, two contrary beam gammaphotons are interfered to a certain degree differentiating that 478keV gammaphoton position and signal exist,
Referred to as noise gammaphoton can impact testing result, and needs remove.In the present embodiment, symmetric mode cloth is set
The pairs of radiation detection portion 411 set can be detected simultaneously by and differentiate this two beams noise gammaphoton, then reduce this noise gamma light
Subsignal can eliminate this noise gammaphoton.Thus the sensitivity and accuracy of detection are improved.
Embodiment two:
Fig. 2 is that a kind of structure of the proton application system of automatic quickly detection boron concentration provided by Embodiment 2 of the present invention is shown
It is intended to, the difference between this embodiment and the first embodiment lies in:
Further include:
Line switching system 200, for switching proton beam；
Neutron capture therapy system 400, for treating the tumor patient for meeting BNCT treatment screening condition.
Line switching system 200 can be in the automatic rapid detection system 300 of boron-containing sample boron concentration and neutron capture therapy
Switch proton beam between system 400；When that proton beam switched to boron-containing sample boron concentration is automatically fast for line switching system 200
When fast detection system 300, start to execute automatic quickly detection boron-containing sample, when line switching system 200 switches proton beam
When to neutron capture therapy system 400, start to execute BNCT treatment.
Since the automatic rapid detection system 300 of boron-containing sample boron concentration is needed with neutron beam irradiating sample, and neutron beam
The proton beam bombardment target for needing high-speed cruising is generated, low energy linear accelerator system 100 can be used under normal circumstances
Generate the proton beam of high-speed cruising；Likewise, neutron capture therapy system 400 needs to irradiate patient, and neutron with neutron beam
The generation of beam needs the proton beam bombardment target of high-speed cruising, and therefore, low energy linear accelerator system 100 can combine and contain
The automatic rapid detection system 300 of boron sample boron concentration, also can joint neutron capture therapy system 400 be used together.
Since low energy linear accelerator system 100 is expensive and huge equipment, starting runs to holding output and stablizes
The time of proton beam is also longer, under normal circumstances, without exception after opening 100 steady operation of low energy linear accelerator system
It does not shut down when situation, to guarantee that proton beam can stablize output, i.e. low energy linear accelerator system 100 understands 24 hours one day not
The stable proton beam of intermittent output, and the automatic rapid detection system 300 of boron-containing sample boron concentration do not need it is one day 24 small
When it is continual carry out boron-containing sample detection, likewise, neutron capture therapy system 400 does not need 24 hours one day not yet
Intermittent progress BNCT treatment.If low energy linear accelerator system 100 and boron-containing sample boron concentration quick detection system automatically
System 300 is used cooperatively or low energy linear accelerator system 100 are used cooperatively with neutron capture therapy system 400, can all be made
Low energy linear accelerator system 100 cannot be fully utilized, and cause the waste of resource.
In the present embodiment, by low energy linear accelerator system 100 simultaneously with boron-containing sample boron concentration quick detection system automatically
System 300 and neutron capture therapy system 400 are used cooperatively, on the one hand, low energy linear accelerator system 100 can be enable to obtain more
It adequately utilizes, reduces resource waste；On the other hand, by the automatic rapid detection system 300 of boron-containing sample boron concentration and neutron
It captures 400 integration of equipments for the treatment of system together, makes that functions of the equipments are strong, integrated level is high, and neutron capture therapy system 400 is not required to
It to be equipped with additional detection device again, reduces equipment input cost.
Specifically, low energy linear accelerator system 100 by line switching system 200 respectively with boron-containing sample boron concentration from
Dynamic rapid detection system 300 is connected with neutron capture therapy system 400.Line switching system 200 can add low energy straight line
The direction for the proton beam that fast device system 100 generates is adjusted, for example, when needing to carry out boron sample detection, line switching
System 200 can be adjusted the direction of proton beam, so that proton beam with straight direction is incident on boron-containing sample boron dense
Automatic rapid detection system 300 is spent, when needing to carry out BNCT treatment, line switching system 200 can be to the side of proton beam
To being adjusted, proton beam is enable to be incident on neutron capture therapy system 400 with straight direction.
In the present embodiment, pass through the automatic rapid detection system 300 of boron-containing sample boron concentration and neutron capture therapy system 400
Switching, the utilization rate of low energy linear accelerator system 100 can be improved.For example, can be when daytime, by proton beam
Switch to neutron capture therapy system 400 and carry out BNCT treatment, at night when proton beam switched into boron-containing sample boron
The automatic rapid detection system 300 of concentration carries out boron sample detection.For example, can be in the free time of neutron capture therapy system 400
Between use the automatic rapid detection system of boron-containing sample boron concentration, because BNCT treatment before need to be patient put position, give patient inject boron
The preparations such as medicine, regular check patient's body blood boron concentration, take a long time, therefore the preparation before carrying out BNCT and treating
When, proton beam can be switched to the automatic rapid detection system 300 of boron-containing sample boron concentration and carry out boron sample detection, work as BNCT
Before treating after the completion of preparation, then proton beam is switched into neutron capture therapy system 400 and carries out BNCT treatment, works as BNCT
After treatment end, then proton beam is switched into the automatic rapid detection system 300 of boron-containing sample boron concentration and carries out boron-containing sample inspection
Preparation before the BNCT for surveying, and carrying out next patient is treated, recycles repeatedly.
Similarly, as long as carrying out appropriate scale to gamma detection device, the automatic rapid detection system of boron-containing sample boron concentration
300 can be used for other micro or trace element fast automatic detectings and analysis.
Embodiment three:
Fig. 3 is that a kind of structure of the proton application system for automatic quickly detection boron concentration that the embodiment of the present invention three provides is shown
It is intended to, the difference between this embodiment and the first embodiment lies in:
Further include:
Line switching system 200, for switching proton beam；
Radionuclide production system 500 is produced and is extracted for radionuclide.
Line switching system 200 can be raw in the automatic rapid detection system 300 of boron-containing sample boron concentration and radionuclide
Switch proton beam between production system 500；When that proton beam switched to boron-containing sample boron concentration is automatic for line switching system 200
When rapid detection system 300, start to execute automatic quickly detection boron-containing sample, when line switching system 200 cuts proton beam
When shifting to radionuclide production system 500, starts to execute radionuclide production and extract.
Since the automatic rapid detection system 300 of boron-containing sample boron concentration is needed with neutron beam irradiating sample, and neutron beam
The proton beam bombardment target for needing high-speed cruising is generated, low energy linear accelerator system 100 can be used under normal circumstances
Generate the proton beam of high-speed cruising；Likewise, radionuclide production system 500 needs to be banged with the proton beam of high-speed cruising
Specific target nucleus is hit, therefore, low energy linear accelerator system 100 can combine the automatic rapid detection system of boron-containing sample boron concentration
300, it can also combine radionuclide production system 500 and be used together.
Since low energy linear accelerator system 100 is expensive and huge equipment, starting runs to holding output and stablizes
The time of proton beam is also longer, under normal circumstances, without exception after opening 100 steady operation of low energy linear accelerator system
It does not shut down when situation, to guarantee that proton beam can stablize output, i.e. low energy linear accelerator system 100 understands 24 hours one day not
The stable proton beam of intermittent output, and the automatic rapid detection system 300 of boron-containing sample boron concentration do not need it is one day 24 small
When it is continual carry out boron-containing sample detection, likewise, radionuclide production system 500 does not need 24 hours one day yet
It runs without interruption.If low energy linear accelerator system 100 and the automatic rapid detection system 300 of boron-containing sample boron concentration cooperate
It uses or low energy linear accelerator system 100 is used cooperatively with radionuclide production system 500, all low energy can be made straight
Line accelerator system 100 cannot be fully utilized, and cause the waste of resource.
In the present embodiment, by low energy linear accelerator system 100 simultaneously with boron-containing sample boron concentration quick detection system automatically
System 300 and radionuclide production system 500 are used cooperatively, on the one hand, low energy linear accelerator system 100 can be enable to obtain
It more fully utilizes, reduces resource waste；On the other hand, it by the automatic rapid detection system of boron-containing sample boron concentration 300 and puts
500 integration of equipments of penetrating property nucleic production system together, makes that functions of the equipments are strong, integrated level is high.
Specifically, low energy linear accelerator system 100 by line switching system 200 respectively with boron-containing sample boron concentration from
Dynamic rapid detection system 300 is connected with radionuclide production system 500.Line switching system 200 can be to low energy straight line
The direction for the proton beam that accelerator system 100 generates is adjusted, for example, line is cut when needing to carry out boron sample detection
The direction of proton beam can be adjusted by changing system 200, and proton beam is enable to be incident on boron-containing sample boron with straight direction
The automatic rapid detection system 300 of concentration, when needing to carry out radionuclide production and extracting, line switching system 200 can be with
The direction of proton beam is adjusted, proton beam is enable to be incident on radionuclide production system 500 with straight direction.
In the present embodiment, pass through the automatic rapid detection system 300 of boron-containing sample boron concentration and radionuclide production system
The utilization rate of low energy linear accelerator system 100 can be improved in 500 switching.For example, it may be by proton when daytime
Line switches to the automatic rapid detection system 300 of boron-containing sample boron concentration and carries out boron sample detection, at night when, by proton
Line switches to radionuclide production system 500 and carries out radionuclide production and extraction.
Example IV:
Fig. 4 is that a kind of structure of the proton application system for automatic quickly detection boron concentration that the embodiment of the present invention four provides is shown
It is intended to, the difference between this embodiment and the first embodiment lies in:
Further include:
Line switching system 200, for switching proton beam；
Neutron capture therapy system 400, for treating the tumor patient for meeting BNCT treatment screening condition；
Radionuclide production system 500 is produced and is extracted for radionuclide.
Line switching system 200 can be in the automatic rapid detection system 300 of boron-containing sample boron concentration, neutron capture therapy system
Switch proton beam between system 400 and radionuclide production system 500；When line switching system 200 switches proton beam
When rapid detection system 300 automatic to boron-containing sample boron concentration, starts to execute automatic quickly detection boron sample, be when line switches
When proton beam is switched to neutron capture therapy system 400 by system 200, start to execute BNCT treatment, when line switching system 200
When proton beam is switched to radionuclide production system 500, starts to execute radionuclide production and extract.
Specifically, low energy linear accelerator system 100 by line switching system 200 respectively with boron-containing sample boron concentration from
Dynamic rapid detection system 300, neutron capture therapy system 400 are connected with radionuclide production system 500.Line switching system
The direction for the proton beam that system 200 can generate low energy linear accelerator system 100 is adjusted, for example, when needing to carry out
When boron-containing sample detects, line switching system 200 can be adjusted the direction of proton beam, enable proton beam with straight
It is incident on the automatic rapid detection system 300 of boron-containing sample boron concentration, when needing to carry out BNCT treatment, line switching system in direction
200 can be adjusted the direction of proton beam, and proton beam is enable to be incident on neutron capture therapy system with straight direction
400, when needing to carry out radionuclide production and extracting, line switching system 200 can be carried out the direction of proton beam
Adjustment, enables proton beam to be incident on radionuclide production system 500 with straight direction.
In the present embodiment, pass through the automatic rapid detection system 300 of boron-containing sample boron concentration, neutron capture therapy system 400
With the switching of radionuclide production system 500, the utilization rate of low energy linear accelerator system 100 can be improved.For example, can be with
Proton beam is switched into the automatic rapid detection system 300 of boron-containing sample boron concentration or neutron capture therapy when daytime
It is automatically fast can be switched to boron-containing sample boron concentration in preparation before carrying out BNCT and treating by system 400 for proton beam
Fast detection system 300 carries out boron sample detection, switches to neutron after the completion of BNCT treats preceding preparation, then by proton beam
It captures treatment system 400 and carries out BNCT treatment, switch to boron-containing sample boron concentration after BNCT treatment end, then by proton beam
Automatic rapid detection system 300 carries out boron sample detection；When at night, proton beam is switched into radionuclide production
System 500 carries out radionuclide production and extraction.
Embodiment five:
Fig. 5 is a kind of operation side of the proton application system for automatic quickly detection boron concentration that the embodiment of the present invention five provides
The flow diagram of method, the proton that the operating method of the present embodiment can be adapted for carrying out boron-containing sample detection by neutron beam are answered
With system, such as it can be the proton of the proton application system of embodiment one, the proton application system of embodiment two, embodiment three
Application system, the proton application system of example IV.Specifically includes the following steps:
S100: neutron beam quality parameter measurement；
S200: the standard boron-containing sample of known boron concentration is detected；
S300: calibration prompt fission gammas tests and analyzes device；
S400: the boron-containing sample to be tested of unknown boron concentration is detected；
S500: obtaining the boron concentration information of boron-containing sample to be measured, and repeat step S400, handles next to be measured contain
Boron sample, until the detection of all samples to be tested finishes.
Specifically, in the detection process, after the boron concentration for obtaining a sample to be tested, repeating step S400, using neutron
Beam irradiates next boron-containing sample to be tested, can be obtained the boron concentration of next sample, so recycles, until all to be tested
Boron sample detection finishes.
Specifically, in step S200: in the standard boron-containing sample for detecting known boron concentration, comprising:
S210: detecting and controlling system 306 closes the line gate 3026 of neutron-exposure facility 302；
S220: boron-containing sample automatic sampling apparatus 303 is used, the standard boron-containing sample of boron concentration known to portion is sent to
At 3026 port of line gate of neutron-exposure facility 302；
S230: detecting and controlling system 306 opens the line gate 3026 of neutron-exposure facility 302；
S240: neutron beam irradiates the standard boron-containing sample of the known boron concentration, and obtains qualified gamma spectra or arrive
Up to the detection time limit.
Specifically, S300: calibration prompt fission gammas tests and analyzes device, comprising:
S310: the detection parameters for testing and analyzing 304 calculation part 3044 of device to prompt fission gammas initialize；
S320: prompt fission gammas tests and analyzes device reception neutron beam and sample occurs the prompt fission gammas that nuclear reaction is released and penetrates
Line, until obtain qualified gamma spectra or reach the detection time limit, detecting and controlling system 306 is by neutron-exposure facility 302
Line gate 3026 is closed；
S330: prompt fission gammas tests and analyzes device 304 and uses the detection of the representative of the acquisition standard boron-containing sample boron concentration
Boron concentration information known to signal message and the standard boron sample tests and analyzes device 304 to prompt fission gammas and carries out scale.
Specifically, step S400: detecting the boron-containing sample to be tested of unknown boron concentration, comprising:
S410: detecting and controlling system 306 closes the line gate 3026 of neutron-exposure facility 302；
S420: boron-containing sample automatic sampling apparatus 303 is used, boron-containing sample to be tested is sent to neutron-exposure facility
At 302 3026 port of line gate；
S430: detecting and controlling system 306 opens the line gate 3026 of neutron-exposure facility 302；
S440: neutron beam irradiates the boron-containing sample to be tested.
Specifically, S500: obtaining the boron concentration information of boron-containing sample to be measured, comprising:
S510: gamma tests and analyzes device reception neutron beam and boron-containing sample to be tested occurs to send out gal in the wink that nuclear reaction is released
Horse ray, until obtaining qualified gamma spectra or reaching the detection time limit；
S520: detecting and controlling system 306 closes the line gate 3026 of neutron-exposure facility 302；
S530: prompt fission gammas tests and analyzes device 304 and uses the inspection of the representative of the acquisition boron-containing sample boron concentration to be tested
The probe response information of signal message and corrected gamma ray and the number curve of boron concentration relationship are surveyed, is obtained to be measured
Try the boron concentration of boron-containing sample.
More specifically, when examination criteria boron-containing sample is with boron-containing sample to be tested is detected, operating procedure is essentially identical, all
It is to need first to close line gate 3026, boron-containing sample is moved to irradiation position under no neutron beam irradiating state, to sample
It after the completion of putting, then opens line gate 3026 and is irradiated, it is ensured that the standard of safety and sample detection in operating process
True property；But examination criteria boron-containing sample is different with the purpose for detecting boron-containing sample to be tested, examination criteria boron-containing sample be in order to
It tests and analyzes device 304 to prompt fission gammas to be corrected, detection device caused by the difference to eliminate the conditions such as equipment, environment is rung
Answer error；Detect the boron concentration information that boron-containing sample to be tested is boron-containing sample to be tested in order to obtain.Because sample is through neutron beam
Boron concentration in the information and sample of the gamma ray released after irradiation is in certain quantitative relation, wherein prompt fission gammas's detection
It is built-in with the probe response information of gamma ray and the number curve of boron concentration relationship in analytical equipment 304, but needs periodically to make
It is corrected with standard sample.
Embodiment six:
The present embodiment and the difference of embodiment five are:
In the detection before beamlet quality parameter, further includes:
Proton beam is switched into the automatic rapid detection system 300 of boron-containing sample boron concentration using line switching system 200.
After all boron-containing sample detections to be measured finish, further includes:
Proton beam is switched into neutron capture therapy system 400 using line switching system 200, carries out BNCT treatment；
Or
Proton beam is switched into radionuclide production system 500 using line switching system 200, carries out radioactive nucleus
Element production and extraction.
Specifically, when the automatic rapid detection system 300 of proton application system packet boron-containing sample boron concentration of the invention is in
When neutron capture therapy system 400, after the completion of the Concentration Testing of boron sample, neutron prisoner is switched to by line switching system 200
Treatment system 400 is obtained, BNCT treatment is carried out；
When the automatic rapid detection system 300 of proton application system packet boron-containing sample boron concentration of the invention and radionuclide
When production system 500, after the completion of the Concentration Testing of boron sample, it is raw that radionuclide is switched to by line switching system 200
Production system 500 carries out radionuclide production and extraction；
When the automatic rapid detection system 300 of proton application system packet boron-containing sample boron concentration of the invention, neutron absorption are controlled
When treatment system 400 and radionuclide production system 500, after the completion of the Concentration Testing of boron sample, according to actual demand and
It arranges, neutron capture therapy system 400 can be both switched to by line switching system 200, carry out BNCT treatment；It can also lead to
It crosses line switching system 200 and switches to radionuclide production system 500, carry out radionuclide production and extraction.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, it will be understood by those of skill in the art that it still can be right
Technical solution documented by previous embodiment is modified, or is replaced on an equal basis to part of technical characteristic；And these
It modifies or replaces, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (10)
1. a kind of proton application system of automatic quickly detection boron concentration characterized by comprising
Low energy linear accelerator system (100), for generating proton beam and accelerating proton beam energy；
The automatic rapid detection system of boron-containing sample boron concentration (300), the automatic quick boron concentration quantitative for batch boron-containing sample
Measurement, including detection span line (301), neutron-exposure facility (302), boron-containing sample automatic sampling apparatus (303), prompt fission gammas
Test and analyze device (304), line capturing device (305), detecting and controlling system；
The detection span line (301) connect with the low energy linear accelerator system (100), the neutron-exposure facility
(302) it is connect with the detection span line (301), the neutron-exposure facility (302), the boron-containing sample automatic sampling apparatus
(303), the prompt fission gammas tests and analyzes device (304) and connect with the detecting and controlling system electric signal.
2. the proton application system of automatic quickly detection boron concentration according to claim 1, which is characterized in that the neutron
Irradiation unit (302), including beam channel (3021), expand section (3022), target assembly (3023), neutron beam regulating device
(3024), body (3025), line gate (3026), irradiation unit radiation shield (3027) are collimated.
3. the proton application system of automatic quickly detection boron concentration according to claim 1, which is characterized in that the boracic
Sample automatic sampling apparatus (303), including sample supporting part (3031), sample transport unit (3032), driving mechanism (3033).
4. the proton application system of automatic quickly detection boron concentration according to claim 1, which is characterized in that the wink hair
Gamma tests and analyzes device (304), including radiation detection portion (3041), signal processing part (3042), detection device radiation shield
Body (3043), calculation part (3044).
5. the proton application system of automatic quickly detection boron concentration according to claim 1, which is characterized in that further include:
Line switching system (200), for switching to proton beam in different application systems；
Neutron capture therapy system (400), for treating the tumor patient for meeting BNCT treatment screening condition；
And/or radionuclide production system (500), it produces and extracts for radionuclide.
6. a kind of operating method of the proton application system of automatic quickly detection boron concentration, which comprises the following steps:
S100: neutron beam quality parameter measurement；
S200: the standard boron-containing sample of known boron concentration is detected；
S300: calibration prompt fission gammas tests and analyzes device；
S400: the boron-containing sample to be tested of unknown boron concentration is detected；
S500: obtaining the boron concentration information of boron-containing sample to be measured, and repeat step S400, handles next boracic sample to be measured
Product, until the detection of all samples to be tested finishes.
7. the operating method of the proton application system of automatic quickly detection boron concentration according to claim 6, feature exist
In in step S200: in the standard boron-containing sample for detecting known boron concentration, comprising:
S210: detecting and controlling system closes the line gate (3026) of neutron-exposure facility (302)；
S220: using boron-containing sample automatic sampling apparatus (303), and the standard boron-containing sample of boron concentration known to portion is sent to
At line gate (3026) port of sub- irradiation unit (302)；
S230: detecting and controlling system opens the line gate (3026) of neutron-exposure facility (302)；
S240: neutron beam irradiates the standard boron-containing sample of the known boron concentration.
8. the operating method of the proton application system of automatic quickly detection boron concentration according to claim 6, feature exist
In in step S300: calibration prompt fission gammas tests and analyzes in device, comprising:
S310: the detection parameters for testing and analyzing the calculation part (3044) of device (304) to prompt fission gammas initialize；
S320: prompt fission gammas tests and analyzes the prompt gamma ray that device (304) receive neutron and nuclear reaction releasing occurs for sample,
Until obtain qualified gamma spectra or reach the detection time limit, detecting and controlling system is by the line of neutron-exposure facility (302)
Gate (3026) is closed；
S330: prompt fission gammas tests and analyzes device (304) and uses the detection letter of the representative of the acquisition standard boron-containing sample boron concentration
Boron concentration information known to number strength information and the standard boron-containing sample tests and analyzes device (304) to prompt fission gammas and carves
Degree.
9. the operating method of the proton application system of automatic quickly detection boron concentration according to claim 6, feature exist
In before the measurement of neutron beam quality parameter, further includes:
Proton beam is switched into the automatic rapid detection system of boron-containing sample boron concentration (300) using line switching system (200).
10. the operating method of the proton application system of automatic quickly detection boron concentration according to claim 6, feature exist
In further comprising the steps of: after all boron-containing samples to be measured are disposed
Proton beam is switched to neutron capture therapy system (400) using line switching system (200), carries out BNCT treatment；
Or
Proton beam is switched to radionuclide production system (500) using line switching system (200), carries out radioactive nucleus
Element production and extraction.
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| JP7292345B2 (en) | 2021-03-11 | 2023-06-16 | アデルファイ・テクノロジー・インコーポレイテッド | Neutron source with beam shaper for cancer treatment |
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