CN109071462B - 喹唑啉衍生物或其盐和包含其的药物组合物 - Google Patents
喹唑啉衍生物或其盐和包含其的药物组合物 Download PDFInfo
- Publication number
- CN109071462B CN109071462B CN201780025602.4A CN201780025602A CN109071462B CN 109071462 B CN109071462 B CN 109071462B CN 201780025602 A CN201780025602 A CN 201780025602A CN 109071462 B CN109071462 B CN 109071462B
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- Prior art keywords
- amino
- quinazoline
- phenyl
- carbonitrile
- oxo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20160053033 | 2016-04-29 | ||
KR10-2016-0053033 | 2016-04-29 | ||
PCT/KR2017/004424 WO2017188720A2 (fr) | 2016-04-29 | 2017-04-26 | Dérivé de quinazoline ou son sel et composition pharmaceutique le comprenant |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109071462A CN109071462A (zh) | 2018-12-21 |
CN109071462B true CN109071462B (zh) | 2022-02-08 |
Family
ID=60159881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780025602.4A Active CN109071462B (zh) | 2016-04-29 | 2017-04-26 | 喹唑啉衍生物或其盐和包含其的药物组合物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10941136B2 (fr) |
EP (1) | EP3448839B1 (fr) |
JP (1) | JP6909236B2 (fr) |
KR (1) | KR102325899B1 (fr) |
CN (1) | CN109071462B (fr) |
AU (1) | AU2017256488B2 (fr) |
CA (1) | CA3019333C (fr) |
ES (1) | ES2908001T3 (fr) |
WO (1) | WO2017188720A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6909236B2 (ja) * | 2016-04-29 | 2021-07-28 | ユーハン・コーポレイションYUHAN Corporation | キナゾリン誘導体またはその塩およびそれを含む医薬組成物 |
US20200165257A1 (en) * | 2017-06-22 | 2020-05-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Inhibitors of phosphoinositide 3-kinase and histone deacetylase for treatment of cancer |
JP7450541B2 (ja) | 2018-01-20 | 2024-03-15 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | 置換アミノピリミジン化合物及び使用方法 |
CN113929674B (zh) * | 2021-11-22 | 2023-09-22 | 中国药科大学 | 含1,4-二氢喹唑啉结构的化合物及其制备方法与应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102762565A (zh) * | 2010-02-22 | 2012-10-31 | 弗·哈夫曼-拉罗切有限公司 | 吡啶并[3,2-d]嘧啶PI3δ抑制剂化合物及使用方法 |
CN103930422A (zh) * | 2011-07-19 | 2014-07-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
CN104470923A (zh) * | 2012-07-04 | 2015-03-25 | 理森制药股份公司 | 选择性PI3K δ抑制剂 |
WO2015168079A1 (fr) * | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Dérivés de pyrimidine ou de pyridine utiles en tant qu'inhibiteurs de pi3k |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2775942A1 (fr) * | 2009-09-29 | 2011-04-07 | Xcovery Holding Company Llc | Inhibiteurs selectifs de la pi3k (delta) |
JP6909236B2 (ja) * | 2016-04-29 | 2021-07-28 | ユーハン・コーポレイションYUHAN Corporation | キナゾリン誘導体またはその塩およびそれを含む医薬組成物 |
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2017
- 2017-04-26 JP JP2018556304A patent/JP6909236B2/ja active Active
- 2017-04-26 ES ES17789904T patent/ES2908001T3/es active Active
- 2017-04-26 WO PCT/KR2017/004424 patent/WO2017188720A2/fr active Application Filing
- 2017-04-26 US US16/096,712 patent/US10941136B2/en active Active
- 2017-04-26 CA CA3019333A patent/CA3019333C/fr active Active
- 2017-04-26 CN CN201780025602.4A patent/CN109071462B/zh active Active
- 2017-04-26 AU AU2017256488A patent/AU2017256488B2/en active Active
- 2017-04-26 KR KR1020170053608A patent/KR102325899B1/ko active IP Right Grant
- 2017-04-26 EP EP17789904.4A patent/EP3448839B1/fr active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102762565A (zh) * | 2010-02-22 | 2012-10-31 | 弗·哈夫曼-拉罗切有限公司 | 吡啶并[3,2-d]嘧啶PI3δ抑制剂化合物及使用方法 |
CN103930422A (zh) * | 2011-07-19 | 2014-07-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
CN104470923A (zh) * | 2012-07-04 | 2015-03-25 | 理森制药股份公司 | 选择性PI3K δ抑制剂 |
WO2015168079A1 (fr) * | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Dérivés de pyrimidine ou de pyridine utiles en tant qu'inhibiteurs de pi3k |
Also Published As
Publication number | Publication date |
---|---|
WO2017188720A2 (fr) | 2017-11-02 |
EP3448839A4 (fr) | 2019-09-11 |
KR102325899B1 (ko) | 2021-11-12 |
EP3448839B1 (fr) | 2022-02-09 |
US10941136B2 (en) | 2021-03-09 |
CA3019333C (fr) | 2024-01-02 |
ES2908001T3 (es) | 2022-04-27 |
EP3448839A2 (fr) | 2019-03-06 |
JP2019514910A (ja) | 2019-06-06 |
AU2017256488B2 (en) | 2020-12-17 |
KR20170124089A (ko) | 2017-11-09 |
CN109071462A (zh) | 2018-12-21 |
JP6909236B2 (ja) | 2021-07-28 |
US20200325120A1 (en) | 2020-10-15 |
CA3019333A1 (fr) | 2017-11-02 |
WO2017188720A3 (fr) | 2018-07-26 |
AU2017256488A1 (en) | 2018-09-20 |
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