CN109049659A - The method of plasma processing of tubular medical inner surface - Google Patents
The method of plasma processing of tubular medical inner surface Download PDFInfo
- Publication number
- CN109049659A CN109049659A CN201810688347.8A CN201810688347A CN109049659A CN 109049659 A CN109049659 A CN 109049659A CN 201810688347 A CN201810688347 A CN 201810688347A CN 109049659 A CN109049659 A CN 109049659A
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- Prior art keywords
- plasma
- tubular medical
- method described
- gas
- cavity
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
- B29C2059/147—Low pressure plasma; Glow discharge plasma
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
Abstract
The present invention relates to a kind of method of plasma processing of tubular medical inner surface, the following steps are included: forming vacuum in the cavity that the tubular medical inner surface surrounds, then it is passed through the mixed gas of oxygen and argon gas and/or helium in the cavities, and low temperature plasma is generated to handle the inner wall of the tubular medical by plasma discharging teclmiques, wherein, the pressure of the mixed gas is 10Pa-5000Pa.Method of the invention can reduce the sticking coefficient of cell on tubular medical inner surface, reduce the phenomenon that tubular medical generates thrombus and embolism in vivo, while improving the blood compatibility of tubular medical.
Description
Technical field
The present invention relates to medical instrument inner surface treatment technology more particularly to a kind of tubular medical inner surface etc. from
Daughter processing method.
Background technique
Stem cell is damaged for some reason, can jeopardize the immune system and hemopoietic system of people, to solve such disease, needs in human body
Interior progress stem cell bone-marrow transplantation, to realize the treatment of human body hematopoiesis and disease of immune system.In addition, excessive blood loss or execution are big
The patient of type operation usually requires input blood also to maintain internal normal blood circulation.However, the life being in contact with blood
Object medical instrument is faced with thrombosis and embolization problem.Two important components of thrombus are blood platelet and fibrin
It is former.Medical apparatus surface exposure in blood when, these fibrinogens can be adhered at the first time surface, this be thrombus and
The major reason that other problems are formed.Blood platelet and other blood constituents and medical apparatus surface interact in fact not straight
The restriction of material surface is received, and is really determined by being adsorbed on the albumin layer on surface.In general, the blood with adhesion function
Lactoferrin, such as fiber link albumen, and fibrinogen and vWF ELISA etc., these increase the possibility of thrombus
Property, and tend to reduce thromboembolism situation if having the other function such as albumen of albumin.However, caused by thrombus
Embolism happens occasionally in transfusion procedure, and very big life danger is brought to urgent patient.Therefore, a no pollution and tool
There is the medical apparatus surface of lower hemoglobin or fibrinogen adhesive of great advantage to the thrombic character for reducing material surface.
Polyethylene glycol oxide (PEO) surfactant has critically important benefit to medical instrument, and this kind of materials not only have preferable blood
Liquid phase capacitive, while this kind of material surfaces have extremely low fibrin sticking coefficient.But current PEO and medical instrument
Binding force it is lower, be easy to fall off, affect using effect.
The medical instrument of medical industry, such as perfusion tube at present mostly use polyvinyl chloride (PVC), polyethylene
(PE) or polypropylene (PP) material is made, and the blood compatibility of these materials is not very perfect, the perfusion tube in production and processing
Inner wall is also handled without carrying out the cured later of surfactant, even if using also to have the problems such as local binding force is not high to go out more
It is existing.
Summary of the invention
In order to solve the above technical problems, the object of the present invention is to provide a kind of plasmas of tubular medical inner surface
Processing method, method of the invention is convenient and practical, nontoxic and pollution-free to human body and environment, no pernicious gas dissipation, while can have
Effect reduces the sticking coefficient of infusion apparatus inner wall, improves the blood compatibility problem of medical instrument.
The present invention provides a kind of method of plasma processing of tubular medical inner surface, comprising the following steps:
Vacuum is formed in the cavity that tubular medical inner surface surrounds, and is then passed through at 20-30 DEG C in the cavities
The mixed gas of oxygen and argon gas and/or helium, and low temperature plasma is generated by plasma discharging teclmiques to handle pipe
The inner wall of shape medical instrument, wherein the pressure of mixed gas is 10Pa-5000Pa (preferably 10Pa-1000Pa).
Further, the material of tubular medical is polyvinyl chloride (PVC), polyethylene (PE) or polypropylene (PP).
Further, tubular medical is perfusion tube.Perfusion tube is infused or transfuses blood for stem cell.
Further, before not being passed through mixed gas, the initial depression in cavity is less than 50Pa.
Further, tubular medical inner surface is also covered with the macromolecular polymeric for having biocompatibility with blood
Object.After being handled by low temperature plasma the inner wall with macromolecule polyalcohol, solidifies macromolecule polyalcohol, can mention
The binding force of high macromolecule polyalcohol and inner wall further improves the blood compatibility of shape medical instrument inner surface.
Further, macromolecule polyalcohol is polyethylene glycol oxide (PEO).
It is possible to further which macromolecule polyalcohol is covered in tubular medical before low temperature plasma generates
Surface can also be covered on pipe after Low Temperature Plasma Treating crosses the inner wall of tubular medical, then by macromolecule polyalcohol
The inner surface of shape medical instrument.
Further, covering method can be infusion process, cladding process etc..Infusion process is that tubular medical is soaked in big point
In the solution of sub- polymer.
Further, plasma discharging teclmiques are inductively coupled plasma body discharge technology, hollow cathode discharge technology
Or dielectric barrier discharge technology.
Further, the time of Low Temperature Plasma Treating inner wall is 10-300s.When before treatment, tubular medical
When inner surface is covered with macromolecule polyalcohol, the processing time is 10-300s, when before treatment, tubular medical inner surface does not have
When having covering macromolecule polyalcohol, the processing time is 30-300s.
It is discharged by the mixed gas to oxygen and argon gas and/or helium, low temperature plasma is generated, directly to pipe
Shape medical instrument inner wall carries out the activation processing of plasma, and when its material is PVC, plasma is former the chlorine of equipment surfaces
Son is replaced as oxygen atom, when material is PE or PP, plasma the hydrogen atom replacements of equipment surfaces at oxygen atom, to realize
The better blood compatibility of instrument inner wall.
Further, used device includes: when corona treatment
Vacuum suction component, gas supply assembly and plasma discharge component, the vacuum suction component and gas supply assembly
It is separately connected with the both ends of the tubular medical, the vacuum suction device is used to provide vacuum degree for the cavity, institute
Gas supply assembly is stated for be passed through mixing for oxygen and argon gas and/or helium in the cavity that surrounds of the tubular medical inner surface
Gas is closed, the plasma discharge component is connect with the tubular medical, and the plasma discharge component is used for
Low temperature plasma is generated in the cavity.
Further, plasma discharge component is inductively coupled plasma body generator, hollow cathode plasma is lived
Change generator or dielectric barrier discharge.
Further, inductively coupled plasma body generator include radio-frequency power supply, the radio-frequency match that is connect with radio-frequency power supply
Device, several loops connecting with radio frequency adaptation, loop are surrounded on tubular medical outer surface, tubular medical
Outer cover is equipped with quartz ampoule.The frequency range of radio-frequency power supply can be between 2MHz-40.68MHz.Preferably, the frequency of radio-frequency power supply
Rate range can be 13.56MHz.
Further, hollow cathode plasma activation generator includes that high-voltage ac power and high-voltage ac power connect
One end of the two hollow cathode heads connect, two hollow cathode heads is separately connected the both ends of tubular medical, one of them is hollow
The other end of cathode taps is connected to vacuum suction component, and the other end of another hollow cathode head is connected to gas supply assembly.High pressure
The frequency of AC power source is 50Hz-100KHz.
According to the above aspect of the present invention, the present invention has at least the following advantages:
Method of the invention carries out plasma to tubular medical inner surface using discharge of plasma in low temperature technology
Activation, easy to use, nontoxic and pollution-free to human body and environment, no pernicious gas dissipation substantially increases the practicability of technique, is
Large-scale industrial production provides effective way.Simultaneously can be effectively reduced hemoglobin on tubular medical inner surface,
Fibrinogen etc. has the sticking coefficient of adhesive function cell or stem cell, reduces tubular medical and generates thrombus in vivo
And the phenomenon that embolism, the utilization rate of blood or cell is improved, while improving the blood compatibility of tubular medical.
The above description is only an overview of the technical scheme of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, the following is a detailed description of the preferred embodiments of the present invention and the accompanying drawings.
Detailed description of the invention
Fig. 1 is that the present invention uses inductively coupled plasma body technique to carry out plasma-activated processing to tubular medical
The structural schematic diagram of device；
Fig. 2 is that the present invention uses hollow cathode plasma technology to carry out plasma-activated processing to tubular medical
The structural schematic diagram of device；
Description of symbols:
1- first gas tank；2- second gas tank；3- gas flow controller；4- mixes gas tank；The first connector of 5-；6- is defeated
Liquid pipe；7- quartz ampoule；8- copper coil；9- dial barometer；10- radio frequency adaptation；11- radio-frequency power supply；12- hollow cathode head；
The second connector of 13-；14- high-pressure connection line；15- high voltage power supply.
Specific embodiment
With reference to the accompanying drawings and examples, specific embodiments of the present invention will be described in further detail.Implement below
Example is not intended to limit the scope of the invention for illustrating the present invention.
Embodiment one
In the present embodiment, tubular medical is carried out using inductively coupled plasma body technique plasma-activated and solid
Change processing, by taking tubular medical is perfusion tube as an example, specifically used device and method is as follows:
Referring to Fig. 1, processing unit includes vacuum suction component, gas supply assembly and plasma discharge component, and vacuum is taken out
Pneumatic module is connect with one end of perfusion tube 6, and gas supply assembly is connect with the other end of perfusion tube 6.
Vacuum suction component preferably comprises mechanical pump and vacuum exhaust pipe, and vacuum exhaust pipe and perfusion tube 6 pass through card
Hoop is attached.Gas supply assembly connects the other end of perfusion tube 6, and gas supply assembly includes two gas tanks in parallel, and respectively first
Gas tank 1 and second gas tank 2 fill argon gas and/or helium in first gas tank 1, fill oxygen in second gas tank 2.The
One gas tank 1 and second gas tank 2 are connected separately with gas flow controller 3, are used for adjusting gas flow, two gas flow controls
Device 3 processed is by the way that in piping connection to the same mixed gas tank 4, the gas in first gas tank 1 and second gas tank 2 is in mixed gas tank 4
Interior mixing mixes and is provided with dial barometer 9 on gas tank 4, and mixed gas tank 4 is connected to by the first connector 5 with one end of perfusion tube 6.
Plasma discharge component is inductively coupled plasma body generator, including radio-frequency power supply 11 and radio-frequency power supply 11
The copper coil 8 of the radio frequency adaptation 10 of connection, the number circle connecting with radio frequency adaptation 10,8 both ends of copper coil connect radio-frequency match
Device 10.Copper coil 8 is surrounded on outside quartz ampoule 7, and above-mentioned perfusion tube 6 is worn inside quartz ampoule 7.
Corona treatment is carried out to perfusion tube using apparatus above, the specific method is as follows:
(1) perfusion tube 6 before treatment, carries out conventional cleaning and deionized water cleaning.The material of perfusion tube 6 can be polychlorostyrene
Ethylene (PVC), polyethylene (PE) or polypropylene (PP).
(2) perfusion tube 6 after cleaning is assembled in above-mentioned apparatus, is evacuated first with mechanical pump, so that in perfusion tube 6
In vacuum state, first gas tank 1 and second gas tank 2, adjusting gas flow controller 3, so that the first gas are then opened
Gas flow in body tank 1 and second gas tank 2 is 10sccm:1sccm, and gas flows into mixed gas tank 4, flows into after mixing wherein
Perfusion tube 6, it is ensured that the air pressure inside perfusion tube 6 is less than 1000Pa or less.Connection radio-frequency power supply 11, frequency 13.56MHz, this
When perfusion tube 6 inside can generate the plasma of brilliant white, handle the time depending on requiring, generally at 10 seconds by 300 seconds not
Deng.In addition, perfusion tube 6 before plasma treatment, can first be impregnated in a period of time in the solution of PEO, have its inner wall
PEO, if perfusion tube 6 have passed through the dipping of PEO, the discharge time of plasma can be set to greater than 10 seconds.If infusion
Pipe 6 not have passed through the dipping of PEO before plasma treatment, and discharge time can be set to greater than 30 seconds.
If perfusion tube 6 not have passed through the dipping of PEO before plasma treatment, after corona treatment, can incite somebody to action
It is immersed in PEO again, then repeats step (2), to realize the plasma cured processing of PEO.
By the method for the above corona treatment, 6 inner wall of perfusion tube will generate good blood compatibility characteristic.Tentatively
Capillary rise (CR) experiment show (test liquid use NaCl concentration for 0.9% physiological saline), internal diameter is 1.2mm
The not plasma-treated liquid surface of capillarity of perfusion tube, which rises, is up to 20cm, and on the liquid surface of capillarity after corona treatment
It rises and only has 10cm or so.After the dipping of PEO surfactant and using plasma curing process, the capillary solution of CR experiment
Face, which rises, only has 5.5cm or so.It can be seen that there is inside perfusion tube 6 fairly good blood compatibility after corona treatment,
And reduce the sticking coefficient of 6 inner wall of perfusion tube.
Embodiment two
In the present embodiment, tubular medical is carried out using hollow cathode plasma technology plasma-activated and solid
Change processing, by taking tubular medical is perfusion tube as an example, specifically used device and method is as follows:
Referring to fig. 2, processing unit includes vacuum suction component, gas supply assembly and plasma discharge component.
Plasma discharge component is hollow cathode plasma activation generator, including two hollow cathode heads 12, and two is empty
The heart-yin cartridge 12 is connected respectively to the end of perfusion tube 6 by second connector 13 respectively.Two hollow cathode heads 12 also divide
Not Tong Guo high-pressure connection line 14 connect with the two poles of the earth of high voltage power supply 15.One of hollow cathode head 12 connects vacuum suction group
Part, another hollow cathode head 12 connect gas supply assembly.
Vacuum suction component preferably comprises mechanical pump and vacuum exhaust pipe, and vacuum exhaust pipe passes sequentially through hollow cathode
First 12, second connector 13 is connected to perfusion tube 6.Gas supply assembly connects the other end of perfusion tube 6, and gas supply assembly includes two in parallel
Gas tank, respectively first gas tank 1 and second gas tank 2 fill argon gas and/or helium, the second gas in first gas tank 1
Oxygen is filled in body tank 2.First gas tank 1 and second gas tank 2 are connected separately with gas flow controller 3, for adjusting gas
Body flow, two gas flow controllers 3 pass through in piping connection to the same mixed gas tank 4, first gas tank 1 and second gas tank
Gas in 2 mixes in mixed gas tank 4, is provided with dial barometer 9 on mixed gas tank 4, mixes gas tank 4 and passes through the first connector 5, sky
The heart-yin cartridge 12, the second connector 13 are connected to perfusion tube 6.
Corona treatment is carried out to perfusion tube using apparatus above, the specific method is as follows:
(1) perfusion tube 6 before treatment, carries out conventional cleaning and deionized water cleaning.The material of perfusion tube 6 can be polychlorostyrene
Ethylene (PVC), polyethylene (PE) or polypropylene (PP).
(2) perfusion tube 6 after cleaning is assembled in above-mentioned apparatus, is evacuated first with mechanical pump, so that in perfusion tube 6
In vacuum state, first gas tank 1 and second gas tank 2, adjusting gas flow controller 3, so that the first gas are then opened
Gas flow in body tank 1 and second gas tank 2 is 10sccm:1sccm, and gas flows into mixed gas tank 4, flows into after mixing wherein
Perfusion tube 6, it is ensured that the air pressure inside perfusion tube 6 is less than 1000Pa or less.High voltage power supply 15 is connected, is alternating current, frequency is
50Hz-50KHz can generate the plasma of brilliant white at this time inside perfusion tube 6, handle the time depending on requiring, generally exist
It differs within 10 seconds to 300 seconds.In addition, perfusion tube 6 is before plasma treatment, when can first be impregnated in one section in the aqueous solution of PEO
Between, make its inner wall with PEO, if perfusion tube 6 have passed through the dipping of PEO, the discharge time of plasma can be set to greatly
In 10 seconds.If perfusion tube 6 not have passed through the dipping of PEO before plasma treatment, discharge time can be set to greater than 30 seconds.
If perfusion tube 6 not have passed through the dipping of PEO before plasma treatment, after corona treatment, can incite somebody to action
It is immersed in PEO again, then repeats step (2), to realize the plasma cured processing of PEO.
The above is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and
Modification, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of method of plasma processing of tubular medical inner surface, which comprises the following steps:
Vacuum is formed in the cavity that the tubular medical inner surface surrounds, is then passed through oxygen and argon gas in the cavities
And/or the mixed gas of helium, and low temperature plasma is generated by plasma discharging teclmiques to handle the tubular medical
The inner wall of instrument, wherein the pressure of the mixed gas is 10Pa-5000Pa.
2. according to the method described in claim 1, it is characterized by: the material of the tubular medical is polyvinyl chloride, gathers
Ethylene or polypropylene.
3. according to the method described in claim 1, it is characterized by: the tubular medical is perfusion tube.
4. according to the method described in claim 1, it is characterized by: the vacuum degree in cavity is less than before not being passed through mixed gas
50Pa。
5. according to the method described in claim 1, it is characterized by: the tubular medical inner surface is also covered with and blood
Macromolecule polyalcohol with biocompatibility.
6. according to the method described in claim 5, it is characterized by: the macromolecule polyalcohol is polyethylene glycol oxide.
7. according to the method described in claim 1, it is characterized by: the plasma discharging teclmiques are inductively coupled plasma
Body discharge technology, hollow cathode discharge technology or dielectric barrier discharge technology.
8. according to the method described in claim 1, it is characterized by: the time of Low Temperature Plasma Treating inner wall is 10-300s.
9. the method according to claim 1, wherein used device includes: when corona treatment
Vacuum suction component, gas supply assembly and plasma discharge component, the vacuum suction component and gas supply assembly and institute
The both ends for stating tubular medical are separately connected, and the vacuum suction device is used to provide vacuum degree, the confession for the cavity
The gaseous mixture of oxygen and argon gas and/or helium is passed through in the cavity that pneumatic module is used to surround for the tubular medical inner surface
Body, the plasma discharge component are connect with the tubular medical, and the plasma discharge component is used for described
Low temperature plasma is generated in cavity.
10. according to the method described in claim 9, it is characterized by: the plasma discharge component be inductive coupling etc. from
Daughter generator, hollow cathode plasma activation generator or dielectric barrier discharge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810688347.8A CN109049659A (en) | 2018-06-28 | 2018-06-28 | The method of plasma processing of tubular medical inner surface |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810688347.8A CN109049659A (en) | 2018-06-28 | 2018-06-28 | The method of plasma processing of tubular medical inner surface |
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| CN109049659A true CN109049659A (en) | 2018-12-21 |
Family
ID=64817790
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| CN201810688347.8A Pending CN109049659A (en) | 2018-06-28 | 2018-06-28 | The method of plasma processing of tubular medical inner surface |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110496313A (en) * | 2019-09-05 | 2019-11-26 | 牡丹江等离子体物理应用科技有限公司 | Low-temperature plasma therapeutic equipment |
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| CN108148218A (en) * | 2017-12-13 | 2018-06-12 | 中国人民解放军空军工程大学 | A kind of surface layer reforming apparatus and method of modifying for extending polyimide media barrier discharge plasma driver service life |
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| CN1364946A (en) * | 2001-01-11 | 2002-08-21 | 大连理工大学 | Electronically cyclic resonating, microwave plasma reinforcing and metal and organic chemically vapor-phase depositing epitaxial system and technology |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110496313A (en) * | 2019-09-05 | 2019-11-26 | 牡丹江等离子体物理应用科技有限公司 | Low-temperature plasma therapeutic equipment |
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Application publication date: 20181221 |