CN109032528A - A kind of online preprocess method and device of plate PET system - Google Patents
A kind of online preprocess method and device of plate PET system Download PDFInfo
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Abstract
The present invention relates to a kind of online preprocess methods of plate PET system, comprising: the memory headroom of setting storage initial data and the time interval and total acquisition time for acquiring initial data；Initial data is acquired according to the time interval and the total acquisition time；The initial data is stored in the memory headroom and the initial data is pre-processed online, generates pretreated forward data.Described device includes parameter setting module, data acquisition module and data preprocessing module.The initial data that online preprocess method of the invention receives detector reads in calculator memory, online pretreatment is completed on computers, since memory is read and write at any time, read or write speed is far faster than hard disk, therefore for high activity source, guarantee to collect information as complete as possible, solves the problems, such as that program Caton in off-line method collection process, acquisition data have a large amount of lose.
Description
Technical field
The invention belongs to Medical Imaging Technology fields, and in particular to a kind of online preprocess method of plate PET system and
Device.
Background technique
PET (Positron Emission Tomography, positron emission tomography) is a kind of noninvasive in body
Functional imaging technology is widely used in clinical examination and biological study.The core of PET image-forming principle is radioactivity chemical combination
The intracorporal physiological activity of object participant, radioactive compound emit emergent ray, are examined using the detection device for being distributed in human peripheral
These rays are surveyed, the distribution and flowing of base substance important in organism can be then tracked.With common in PET18F is aobvious
As for,18F-FDG is the analog of glucose, is ingested the mode into cell as glucose, and injection enters human body
Interior18Image caused by F just reflects the level distribution of glucose metabolism in human body.Due to the glucose of malignant cell
Metabolism can be much higher than normal tissue cell, therefore18F is clinically widely used in the diagnosis of malignant tumour.Radioactive tracer
In agent18F can decay, and release a positive electron and a neutrino.Positive electron in human body eventually with an electricity
Son combines, and can bury in oblivion later.In most cases, it can generate that a pair of of energy is identical, heading after burying in oblivion simultaneously
The γ photon of (angle is 180 °) on the contrary.Since the photon energy for burying in oblivion generation is very high, can easily penetrate
Human body, the detection device for being centered around human peripheral carry out space orientation, then restore three-dimensional figure out using image reconstruction algorithm
Picture.
Spacing is adjustable between plate PET system detector, and the suitable detection visual field can be arranged for privileged site, thus
The drug for largely improving the sensitivity of PET system, therefore low-activity can be used carries out related experiment to obtain ideal
PET imaging.PET data pretreatment is, by a series of processing, to obtain LOR on the basis of collected initial data
The counting for meeting event in (Line of Response, line of response), is then rebuild with this data, obtains test articles
Three-dimensional reconstruction image.
Traditional plate PET pretreatment process carries out data to meet processing, acquisition meets thing based on off-line data
Part pair, to obtain LOR information.The acquisition for meeting event pair mainly passes through that the time meets and energy meets judgement, that is, detects
To two events meet reaching time-difference less than certain time and the two energy all in a certain range, then it is assumed that the two things
Part is true coincidence event pair.Plate PET Several Traditional Preconditioning Methods work as radioactive source activity based on the off-line data being saved in hard disk
When larger (about 500uCi), there are a large amount of single events, when data write computer hard disc by Ethernet transmission, the read-write speed of hard disk
Degree does not catch up with transmission speed, may cause the loss of data of part, causes biggish shadow for the image quality of PET system entirety
It rings.
Summary of the invention
In order to solve the above-mentioned problems in the prior art, the present invention provides a kind of the online pre- of plate PET system
Processing method.The technical problem to be solved in the present invention is achieved through the following technical solutions:
One aspect of the present invention provides a kind of online preprocess method of plate PET system, comprising:
S1: the memory headroom of setting storage initial data and the time interval and total acquisition time for acquiring initial data；
S2: initial data is acquired according to the time interval and the total acquisition time；
S3: the initial data is stored in the memory headroom and the initial data is pre-processed online, is generated
Pretreated forward data.
In one embodiment of the invention, the S1 includes:
S11: the first memory headroom and the second memory headroom for storing initial data are set；
S12: the time interval of acquisition initial data being arranged by first timer, and it is former that acquisition is arranged by second timer
The total acquisition time of beginning data；
S13: the first Boolean type variable of setting controls the initial data with the value by the first Boolean type variable
Storage location simultaneously determines the memory headroom for carrying out data prediction；
S14: the second Boolean type variable of setting is controlled whether with the value by the second Boolean type variable to described original
Data are pre-processed.
In one embodiment of the invention, the S13 includes:
First Boolean type variable is set, and it is true for setting the initial value of the first Boolean type variable, and is set when described
When the value of first Boolean type variable is true, the initial data is stored in first memory headroom and is set for pre-processing
Initial data position be the second memory headroom；The value when the first Boolean type variable is set as fictitious time, by the original
It is the first memory headroom that beginning data, which are stored in second memory headroom and are set for pretreated initial data position,.
In one embodiment of the invention, the S14 includes:
Second Boolean type variable is set, sets the initial value of the second Boolean type variable as vacation, and set when described
The value of second Boolean type variable pre-processes the initial data when being true, when the value of the second Boolean type variable is false
When the initial data is not pre-processed.
In one embodiment of the invention, the S3 includes:
S31: collected initial data is stored in first memory headroom；
S32: judging whether to reach first time time interval, if it is not, return step S31, if so, by first Boolean type
The value of variable is set to false as, and sets true for the value of the second Boolean type variable；
S33: being stored in second memory headroom for initial data, and to the initial data in first memory headroom into
The online pretreatment of row；
S34: after the completion of online pretreatment, emptying first memory headroom, and by the value of the second Boolean type variable
It is set to false as；
S35: initial data is stored in second memory headroom；
S36: judging whether to reach second of time interval, if it is not, return step S35, if so, by first Boolean type
Variable is set as very, sets true for the value of the second Boolean type variable；
S37: collected initial data is stored in first memory headroom, and to the original in second memory headroom
Beginning data are pre-processed；
After the completion of S38: second pre-processes, second memory headroom is emptied, and by the second Boolean type variable
Value is set to false as；
S39: repeating S31-S38, until reaching total acquisition time.
Another aspect provides a kind of online pretreatment units of plate PET system, comprising:
Parameter setting module, for the time interval and total acquisition time of data acquisition to be arranged；
Data acquisition module, for acquiring data according to the time interval and the total acquisition time；
Data preprocessing module generates pre- for the data to be stored in the memory headroom and are pre-processed online
Forward data that treated.
In one embodiment of the invention, the parameter setting module includes first timer and second timer,
In, the first timer is for setting the time interval；The second timer is for setting the total acquisition time.
In one embodiment of the invention, the time interval is 10s-5min, the total acquisition time is 5min-
5h。
In one embodiment of the invention, the parameter setting module further includes Variable Control unit, the variable control
Unit processed includes the first Variable Control subelement and the second Variable Control subelement, wherein the first Variable Control subelement
For setting the first Boolean type variable of control original data storage location and preprocessed data position, the second variable control
Subunit controls whether to carry out pretreated second Boolean type variable to the initial data for setting.
Compared with prior art, the beneficial effects of the present invention are:
1, the initial data that the online preprocess method of plate PET system of the invention receives detector reads in computer
Memory completes online pretreatment on computers, and since memory is read and write at any time, read or write speed is far faster than hard disk, therefore for height
Activity source, it is ensured that information as complete as possible can be collected, solve program Caton in off-line method collection process, acquisition data
There are problems that largely losing, more true reconstruction image can be obtained.
2, during replacing hard disk using memory, since maximum memory is generally much less than total data size, the present invention
Online preprocess method and device acquisition and preprocessing process in collected initial data carry out piecemeal storage, in real time
Pretreatment empties memory after the completion of processing, future time segment data is read in the memory emptied, to directly generate pretreatment
Data afterwards improve pretreated efficiency, solve the problems, such as that data volume is excessive.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of plate PET system provided in an embodiment of the present invention；
Fig. 2 is a kind of flow chart of the online preprocess method of plate PET system provided in an embodiment of the present invention；
Fig. 3 is a kind of detail flowchart of the online preprocess method of plate PET system provided in an embodiment of the present invention；
Fig. 4 is the acquisition data volume comparison of online preprocess method and off-line preprocessing method provided in an embodiment of the present invention
Figure；
Fig. 5 is a kind of module diagram of the online pretreatment unit of plate PET system provided in an embodiment of the present invention.
Specific embodiment
The content of present invention is further described combined with specific embodiments below, but embodiments of the present invention are not limited to
This.
Embodiment one
Referring to Figure 1, Fig. 1 is a kind of structural schematic diagram of plate PET system provided in an embodiment of the present invention.The present embodiment
Plate PET system include sequentially connected detector module 1, online preprocessing module 2 and image reconstruction module 3.Detector
Module 1 generates and sends the initial data comprising γ photon information for receiving γ photon, and initial data here is one group
The data of 16 bytes, the information such as time of incidence, position and energy including γ photon.In the present embodiment, detector module 1
Including four detectors, four detectors form rectangle structure, and each detector is individually positioned in one of rectangle structure
On angle.The memory headroom that online preprocessing module 2 is used to receive initial data and its piecemeal is saved in PC (personal computer)
In, the data in memory headroom are pre-processed in real time then, finally obtain pretreated data.In the present embodiment,
In online preprocessing process, piecemeal is carried out simultaneously for data acquisition and data prediction.Described image is rebuild module 3 and is calculated by rebuilding
Method, the data that pretreatment is obtained carry out three-dimensional reconstruction, generate three-dimensional visualization image.
Fig. 2 is referred to, Fig. 2 is a kind of stream of the online preprocess method of plate PET system provided in an embodiment of the present invention
Cheng Tu.The online preprocess method of the present embodiment includes:
S1: the memory headroom of setting storage initial data and the time interval and total acquisition time for acquiring initial data；
S2: initial data is acquired according to the time interval and the total acquisition time；
S3: the initial data is stored in the memory headroom and the initial data is pre-processed online, is generated
Pretreated forward data.
Specifically, the S1 includes:
S11: the first memory headroom and the second memory headroom for storing initial data are set；
As described above, in the present embodiment, the plate PET system includes four detectors, each detector is respectively provided with
There are two memory headrooms, in total include eight memory headrooms, and the magnitude range of the memory headroom is 100MB-2GB.
S12: the time interval of acquisition initial data being arranged by first timer, and it is former that acquisition is arranged by second timer
The total acquisition time of beginning data；
In the present embodiment, the time interval is -5 minutes 10 seconds, the total acquisition time is -5 hours 5 minutes.
S13: the first Boolean type variable of setting controls the initial data with the value by the first Boolean type variable
Storage location simultaneously determines the memory headroom for carrying out data prediction；
Specifically, the first Boolean type variable C1 is set, so that the initial value of the first Boolean type variable C1 is true, and
Set when the value of the first Boolean type variable C1 as it is true when the initial data be stored in first memory headroom and set
Surely carrying out pretreated initial data position is the second memory headroom, when the value of the first Boolean type variable C1 is fictitious time
It is that the initial data of acquisition, which is stored in second memory headroom, and is set for pretreated initial data position
One memory headroom.
S14: the second Boolean type variable of setting is controlled whether with the value by the second Boolean type variable to described original
Data are pre-processed.
Specifically, the second Boolean type variable C2 is set, so that the initial value of the second Boolean type variable C2 is false, and
Set when the value of the second Boolean type variable C2 as it is true when the initial data is pre-processed, when second Boolean type
The value of variable C2 is that fictitious time does not pre-process the initial data.
Further, in the present embodiment, step S3 includes:
S31: the initial value according to C1 is very, by collected initial data storage to first memory headroom；
S32: judging whether to reach first time time interval, if it is not, return step S21, if so, by first Boolean type
The value of variable C1 is set to false as, and sets true for the value of the second Boolean type variable C2；
S33: the value according to C1 is vacation, collected initial data is stored in second memory headroom, according to the value of C2
Be true and C1 value be it is false, the initial data in first memory headroom is pre-processed；
S34: after the completion of pre-processing for the first time, first memory headroom is emptied, by the second Boolean type variable C2's
Value is set to false as；
Under normal conditions, pretreatment time is less than acquisition time, after the completion of pretreatment, removes the number in pretreatment memory
According to changing simultaneously the value of C2, close preprocessing process in order to avoid there is mistake when write-in data next time.
S35: initial data is stored in second memory headroom, without pretreatment operation；
S36: judging whether to reach second of time interval, if it is not, return step S35, if so, by first boolean
Type variable C1 is set as very, sets true for the value of the second Boolean type variable C2；
S37: the value according to C1 is that collected initial data is very stored in first memory headroom, is according to the value of C2
True and C1 value is very to pre-process to the initial data in second memory headroom；
After the completion of S38: second pre-processes, second memory headroom is emptied, and by the second Boolean type variable C2
Value be set to false as.
S39: repeating S31-S38, until reaching total acquisition time.
Specifically, step S31-S38 is repeated, continues collected initial data being stored in first memory headroom, together
When the initial data in second memory headroom is pre-processed and is emptied, and so on, in first memory headroom
Be alternately carried out in second memory headroom data storage, pretreatment, remove；It finishes and goes forward side by side to last group of data acquisition
After row pretreatment, final forward data is formed.
It is (personal that the initial data received is read in PC first by the online preprocess method of the present embodiment plate PET system
Computer) memory, the online pretreatment of plate PET is completed on PC, since memory is read and write at any time, read or write speed far faster than hard disk,
Therefore for high activity source, it is ensured that information as complete as possible can be collected, solve program card in off-line method collection process
, acquisition data there are a large amount of loss, so as to obtain more true reconstruction image.
Embodiment two
Fig. 3 is referred to, Fig. 3 is a kind of the detailed of the online preprocess method of plate PET system provided in an embodiment of the present invention
Thin flow chart.
In the present embodiment, using containing radionuclide18The EP pipe (micro centrifugal pipe) of F-FDG is scanned, and is scanned
When activity be 500uCi.Using four detectors, arranged opposite, is placed in a pair of of vision detector center for EP pipe two-by-two.
Specific step is as follows for the online preprocess method of the present embodiment:
Step 1: setting relevant parameter；
Specifically, two timers t1 and t2 are set, the time interval T of control acquisition initial data is respectively used toGWith it is total
Acquisition time TC, wherein setting acquisition time interval TGIt is 60 seconds, total acquisition time TCIt is 10 minutes.In the present embodiment, institute
Stating plate PET system includes four detectors, and each detector is respectively provided with there are two memory headroom, in total includes eight memory skies
Between, the first memory headroom M1 of 500M is opened up to each detectoriWith the second memory headroom M2 of 500Mi(i is detector number,
I=1,2,3,4), always open up 4G memory headroom.Further, the first Boolean type variable C1 is set, so that C1 value will adopt when being true
It is that the second memory is empty that the data of collection, which are stored in first memory headroom and are set for pretreated initial data position,
Between, C1 value is that the data of acquisition are stored in second memory headroom and are set for where pretreated initial data by fictitious time
Position is the first memory headroom, wherein the initial value of the first Boolean type variable C1 is true；Second Boolean type variable is set
C2, so that pre-processing when C2 value is true to the data, C2 value is that fictitious time does not pre-process the data, wherein
The initial value of the second Boolean type variable C2 is false.
Step 2: data acquisition and pretreatment；
(a) initial data is acquired by detector, is that collected initial data is very stored in the first memory according to C1 value
Space M1i(i=1,2,3,4), while being false without pretreatment according to C2 value；
(b) judge whether the time of timer t1 reaches 60 seconds, when not reaching, return step (a) changes when reached
Become the value of C1 and C2, i.e., the value of C1 becomes false, and the value of C2 becomes true；
It (c) is false by collected initial data deposit the second region of memory M2i (i=1,2,3,4) according to C1 value, simultaneously
Value according to C2 is really to be pre-processed, and C1 value is if false, pre-process the first memory headroom M1i (i=1,2,3,4), in advance
The first memory headroom M1i is emptied after the completion of processing, the value of C2 becomes false；
(d) judge whether the time of timer t1 reaches 60 seconds herein, when not reaching, continue collected original number
According to the second region of memory M2i of deposit and without pretreatment, when reached, changing the value of C1 and C2, i.e. the value of C1 becomes very,
And the value of C2 becomes true；
It (e) is that collected initial data is very stored in first piece of region of memory M1i according to C1 value, while according to the value of C2
It is really to be pre-processed, the value of C1 is if true, pre-process the second region of memory M2i, by the second memory after the completion of pretreatment
Region M2i is emptied, and the value of C2 becomes false；
(f) step (a)-(e) is repeated, until the time of timer t2 reaches 10 minutes, acquisition and pretreatment terminate, and generate
Pretreated forward data.
As described above, collected initial data continues storage into first piece of region of memory M1i, while to the second memory
Data in the M2i of region are pre-processed, and so on, constantly in first piece of region of memory M1i and the second region of memory M2i
In be alternately carried out the work that data are written, pre-process, clearing data.Until last group of data acquisition finishes, it is carried out
Pretreatment, finally obtains forward data.
Further, in the present embodiment, by the qualitative and quantitative analysis of reconstruction image, can be used for judging online pre-
The correctness and validity of processing module.The algorithm being commonly used in PET image reconstruction has FBP (Filtered-back
Projection, filtered back projection) algorithm, MLEM (Maximum Likelihood Expectation Maximization,
It is expected that maximum maximum likelihood) algorithm and OSEM (Ordered Subset Expectation Maximization, orderly son
Collect expectation maximization) algorithm etc., MLEM algorithm can be chosen in the present embodiment, and image is rebuild.
Fig. 4 is referred to, Fig. 4 is the acquisition of online preprocess method and off-line preprocessing method provided in an embodiment of the present invention
Data volume comparison diagram.As figure shows, when inject activity be 45 μ Ci, 50 μ Ci and 85 μ Ci when, off-line method acquisition data volume with
The data volume of online preprocess method acquisition is roughly the same in the present embodiment, however, working as higher (500 μ of activity of drug for injection
When Ci), the data volume of online preprocess method acquisition is noticeably greater than the data volume of off-line method acquisition in the present embodiment, this be because
Due to read or write speed of hard disk etc., the loss of data of some during writing data into hard disk, and
Writing the data directly into memory can be to avoid this problem.
Embodiment three
On the basis of the above embodiments, the online pretreatment unit for present embodiments providing a kind of plate PET system, is asked
It is a kind of module diagram of the online pretreatment unit of plate PET system provided in an embodiment of the present invention referring to Fig. 5, Fig. 5.It should
Pretreatment unit includes: online
Parameter setting module 101, for the time interval and total acquisition time of data acquisition to be arranged；
Data acquisition module 102, for acquiring data according to the time interval and the total acquisition time；
Data preprocessing module 103 is generated for the data to be stored in the memory headroom and are pre-processed online
Pretreated forward data.
Further, the parameter setting module 101 includes first timer and second timer, wherein described first
Timer is for setting the time interval；The second timer is for setting the total acquisition time.In the present embodiment,
The time interval is 10s-5min, the total acquisition time is 5min-5h.
Further, the parameter setting module further includes Variable Control unit, and the Variable Control unit includes first
Variable Control subelement and the second Variable Control subelement, wherein the first Variable Control subelement is former for setting control
Beginning data storage location and the first Boolean type variable of preprocessed data position, the second Variable Control subelement is for setting
Surely it controls whether to carry out pretreated second Boolean type variable to the initial data.In the present embodiment, the parameter setting
Module can be PC.In addition, the PC also provides for memory headroom needed for storage acquires data.In the present embodiment, it is
Each detector is respectively provided with there are two memory headroom, for carrying out piecemeal storage and pretreatment to data.
During replacing hard disk using memory, since maximum memory is generally much less than total data size, the present embodiment
Online preprocess method acquisition and preprocessing process in data carry out piecemeal storage, in real time pre-process, after the completion of processing
Memory is emptied, future time segment data is read in the memory emptied and is improved pre- to directly generate pretreated data
The efficiency of processing.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (9)
1. a kind of online preprocess method of plate PET system characterized by comprising
S1: the memory headroom of setting storage initial data and the time interval and total acquisition time for acquiring initial data；
S2: initial data is acquired according to the time interval and the total acquisition time；
S3: being stored in the memory headroom for the initial data and pre-processed online to the initial data, generates pre- place
Forward data after reason.
2. online preprocess method according to claim 1, which is characterized in that the S1 includes:
S11: the first memory headroom and the second memory headroom for storing initial data are set；
S12: the time interval of acquisition initial data being arranged by first timer, and acquisition original number is arranged by second timer
According to total acquisition time；
S13: the first Boolean type variable of setting controls the storage of the initial data with the value by the first Boolean type variable
Position simultaneously determines the memory headroom for carrying out data prediction；
S14: the second Boolean type variable of setting is controlled whether with the value by the second Boolean type variable to the initial data
It is pre-processed.
3. online preprocess method according to claim 2, which is characterized in that the S13 includes:
First Boolean type variable is set, and it is true for setting the initial value of the first Boolean type variable, and sets and work as described first
When the value of Boolean type variable is true, the initial data is stored in first memory headroom and is set for pretreated original
Beginning data position is the second memory headroom；The value when the first Boolean type variable is set as fictitious time, by the original number
It is the first memory headroom according to being stored in second memory headroom and being set for pretreated initial data position.
4. online preprocess method according to claim 2, which is characterized in that the S14 includes:
Second Boolean type variable is set, sets the initial value of the second Boolean type variable as vacation, and set and work as described second
The initial data is pre-processed when the value of Boolean type variable is true, when the second Boolean type variable value be fictitious time not
The initial data is pre-processed.
5. online preprocess method according to claim 4, which is characterized in that the S3 includes:
S31: collected initial data is stored in first memory headroom；
S32: judging whether to reach first time time interval, if it is not, return step S31, if so, by the first Boolean type variable
Value be set to false as, set true for the value of the second Boolean type variable；
S33: initial data is stored in second memory headroom, and the initial data in first memory headroom is carried out
Line pretreatment；
S34: after the completion of online pretreatment, first memory headroom is emptied, and the value of the second Boolean type variable is arranged
It is false；
S35: initial data is stored in second memory headroom；
S36: judging whether to reach second of time interval, if it is not, return step S35, if so, by the first Boolean type variable
It is set as true, sets true for the value of the second Boolean type variable；
S37: collected initial data is stored in first memory headroom, and to the original number in second memory headroom
According to being pre-processed；
After the completion of S38: second pre-processes, second memory headroom is emptied, and the value of the second Boolean type variable is set
It is set to vacation；
S39: repeating S31-S38, until reaching total acquisition time.
6. a kind of online pretreatment unit of plate PET system, which is characterized in that described device includes:
Parameter setting module, for the time interval and total acquisition time of data acquisition to be arranged；
Data acquisition module, for acquiring data according to the time interval and the total acquisition time；
Data preprocessing module generates pretreatment for the data to be stored in the memory headroom and are pre-processed online
Forward data afterwards.
7. online pretreatment unit according to claim 6, which is characterized in that the parameter setting module includes first fixed
When device and second timer, wherein the first timer is for setting the time interval；The second timer is for setting
The fixed total acquisition time.
8. online pretreatment unit according to claim 7, which is characterized in that the time interval is 10s-5min, institute
Stating total acquisition time is 5min-5h.
9. online pretreatment unit according to claim 8, which is characterized in that the parameter setting module further includes variable
Control unit, the Variable Control unit include the first Variable Control subelement and the second Variable Control subelement, wherein described
First Variable Control subelement is used to set the first Boolean type of control original data storage location and preprocessed data position
Variable, the second Variable Control subelement control whether to carry out pretreated second boolean to the initial data for setting
Type variable.
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| CN113017857A (en) * | 2021-02-25 | 2021-06-25 | 上海联影医疗科技股份有限公司 | Positioning method, positioning device, computer equipment and storage medium |
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| CN104820452B (en) * | 2015-02-13 | 2018-11-13 | 湖北锐世数字医学影像科技有限公司 | A kind of detector intelligence control system and control method |
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| CN113017857A (en) * | 2021-02-25 | 2021-06-25 | 上海联影医疗科技股份有限公司 | Positioning method, positioning device, computer equipment and storage medium |
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