CN109010395A - A kind of preparation method of the ginkgo emulsifiable paste for soft tissue healing - Google Patents
A kind of preparation method of the ginkgo emulsifiable paste for soft tissue healing Download PDFInfo
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The present invention relates to a kind of preparation methods of emulsifiable paste for soft tissue healing, belong to technical field of traditional Chinese medicine preparation.It comprises the following steps that and takes ginkgo, add water to cook, obtain the first decocting liquid;Radix Angelicae Sinensis is taken, is added water to cook, the second decocting liquid is obtained;It is concentrated after first decocting liquid and the second decocting liquid are merged, obtains concentrate;Alum and sodium bicarbonate will be added in concentrate, water supplement stands, takes supernatant, obtain supernatant;Supernatant is concentrated, concentration clear liquid is obtained, adds emulsifier, preservative, surfactant, consistency modifiers, after heating, be uniformly dispersed, then let cool, add water, stir evenly.Convenient provided by the present invention for the emulsifiable paste use process of soft tissue healing, drug is easily attached to the surface of skin, is improved by energy extraction process, keeps the partial size of the drug in emulsifiable paste small, be easy to absorb;Principal component content in emulsifiable paste is high.
Description
Technical field
The present invention relates to a kind of preparation methods of ginkgo emulsifiable paste for soft tissue healing, belong to traditional chinese medicine preparation technology
Field.
Background technique
Soft tissue injury refers to since extruding, drawing or prolonged load cause muscle, ligament, tendon, blood vessel etc.
A series of damage of soft tissues is a kind of relatively conventional disease of orthopaedics.Soft tissue injury can cause swelling, pain, joint living
It is dynamic limited.If patient fails timely to be treated, it is likely that will lead to the very great harm to human synovial.
Firstly, stability of joint is destroyed.The case where stability of joint is by destroying, that is, we are in daily life
In see dislocation situations such as caused joint soft tissue, tendon fiber be torn, can not repair, cause in next activity
The symptom that situations such as there is also dislocation occurs.The stability in joint is influenced, this is because soft group many after being damaged
The elasticity knitted can all be affected, itself can also be in loose state, particular without the patient by effectively treating
It is even more so.Therefore, these soft tissues also just can not carry out fixed function for the skeletal joint closed on, so as to cause joint
Stability decline.Traumatic arthritis can be induced what is more.After soft tissue injury generation, if treatment is not in time,
It is easy to appear rupture of ligament symptom, and after this symptom time is longer, just easily cause the generation of traumatic arthritis.This symptom is more
The damage of some synovial tissues is seen, because damage is not effectively treated, the function of synovial tissue is caused to be affected drop
The absorbability of low joint fluid leads to occur hydrops phenomenon in articular cavity.
Chinese medicine has the advantages that Small side effects, eutherapeutic.Therefore, it is necessary to develop one kind preferably to repair for soft tissue injury
Multiple traditional Chinese medicine for external application.
Summary of the invention
The technical problems to be solved by the present invention are: proposing a kind of preparation side of emulsifiable paste for soft tissue healing
Method.
Technical solution:
A kind of preparation method of the emulsifiable paste for soft tissue healing, comprises the following steps that
Step 1, by weight, takes 1000 parts of ginkgo, adds water to cook, obtain the first decocting liquid;
Step 2 takes 10 parts of Radix Angelicae Sinensis, adds water to cook, obtains the second decocting liquid;
Step 3 is concentrated after merging the first decocting liquid and the second decocting liquid, obtains concentrate;
20 parts of alum and 40 parts of sodium bicarbonate will be added in step 4 in concentrate, water supplement makes 1000 parts of weight of feed liquid, quiet
It sets 24 hours or more, takes supernatant, obtain supernatant;
Supernatant is concentrated step 5, obtains concentration clear liquid, adds 15~20 parts of emulsifier, 2~4 parts of preservative, surface work
Property 4~8 parts of agent, 12~20 parts of consistency modifiers, after heating, are uniformly dispersed, then let cool, add 50~100 parts of water, stir evenly,
?.
In the step 1, decoct 2 times, each amount of water is 2~4 times of the weight of ginkgo, each decocting time
It is 2~4 hours, merging filtrate after having decocted.
In the step 2, decoct 2 times, each amount of water is 2~4 times of the weight of Radix Angelicae Sinensis, each decocting time
It is 1~3 hour, merging filtrate after having decocted.
In the step 3, the step of concentration is that the volume of filtrate is made to be reduced to 1/3.
In the step 5, the temperature of heating is 50~70 DEG C.
The emulsifier is tristerin.
The preservative is methylparaben.
The surfactant is oleic acid LABRAFIL M 1944CS.
The consistency modifiers are glycerol or propylene glycol.
In the step 2, when decoction, also needs to be added 0.3 part of magnesium sulfate.
In the step 2, after obtaining the second decocting liquid, it is filtered with the ultrafiltration membrane that molecular cut off is 200,000, takes filter
Liquid.
Beneficial effect
Convenient provided by the present invention for the emulsifiable paste use process of soft tissue healing, drug is easily attached to the table of skin
Face is improved by energy extraction process, keeps the partial size of the drug in emulsifiable paste small, be easy to absorb;Principal component content in emulsifiable paste
It is high.
Specific embodiment
In embodiments of the invention, the emulsifiable paste (two annex I F of " Chinese Pharmacopoeia " version in 2010) means drug
It is dissolved or dispersed in emulsion type matrix and forms uniform semisolid external preparation.
Embodiment 1
A kind of preparation method of the emulsifiable paste for soft tissue healing, comprises the following steps that
Step 1 takes ginkgo 1000g, adds water to cook, and decocts 2 times, and each amount of water is 2 times of the weight of ginkgo, and each decocts
Boiling the time is 2 hours, and merging filtrate after having decocted obtains the first decocting liquid;
Step 2 takes Radix Angelicae Sinensis 10g, adds water to cook, and decocts 2 times, each amount of water is 2 times of the weight of Radix Angelicae Sinensis, each decoction
Time is 1 hour, and merging filtrate after having decocted obtains the second decocting liquid;
Step 3 is concentrated after merging the first decocting liquid and the second decocting liquid, so that the volume of filtrate is reduced to 1/3, obtains concentrate;
Alum 20g and sodium bicarbonate 40g will be added in step 4 in concentrate, water supplement makes the weight 1000g of feed liquid, stands 24
Hour or more, supernatant is taken, supernatant is obtained;
Supernatant is concentrated step 5, obtains concentration clear liquid, adds emulsifier 15g, preservative 2g, surfactant 4g, thick
Regulator 12g is spent, heating, the temperature of heating is 50 DEG C, is uniformly dispersed, then let cool, adds water 50g, stir evenly.
Emulsifier is tristerin, and preservative is methylparaben, and surfactant is oleic acid polyethylene glycol glycerol
Ester, consistency modifiers are glycerol.
Embodiment 2
A kind of preparation method of the emulsifiable paste for soft tissue healing, comprises the following steps that
Step 1 takes ginkgo 1000g, adds water to cook, and decocts 2 times, and each amount of water is 4 times of the weight of ginkgo, and each decocts
Boiling the time is 4 hours, and merging filtrate after having decocted obtains the first decocting liquid;
Step 2 takes Radix Angelicae Sinensis 10g, adds water to cook, and decocts 2 times, each amount of water is 4 times of the weight of Radix Angelicae Sinensis, each decoction
Time is 3 hours, and merging filtrate after having decocted obtains the second decocting liquid;
Step 3 is concentrated after merging the first decocting liquid and the second decocting liquid, so that the volume of filtrate is reduced to 1/3, obtains concentrate;
Alum 20g and sodium bicarbonate 40g will be added in step 4 in concentrate, water supplement makes the weight 1000g of feed liquid, stands 24
Hour or more, supernatant is taken, supernatant is obtained;
Supernatant is concentrated step 5, obtains concentration clear liquid, adds emulsifier 20g, preservative 4g, surfactant 8g, thick
Regulator 20g is spent, heating, the temperature of heating is 70 DEG C, is uniformly dispersed, then let cool, adds water 100g, stir evenly.
Emulsifier is tristerin, and preservative is methylparaben, and surfactant is oleic acid polyethylene glycol glycerol
Ester, consistency modifiers are glycerol.
Embodiment 3
A kind of preparation method of the emulsifiable paste for soft tissue healing, comprises the following steps that
Step 1 takes ginkgo 1000g, adds water to cook, and decocts 2 times, and each amount of water is 3 times of the weight of ginkgo, and each decocts
Boiling the time is 3 hours, and merging filtrate after having decocted obtains the first decocting liquid;
Step 2 takes Radix Angelicae Sinensis 10g, adds water to cook, and decocts 2 times, each amount of water is 3 times of the weight of Radix Angelicae Sinensis, each decoction
Time is 2 hours, and merging filtrate after having decocted obtains the second decocting liquid;
Step 3 is concentrated after merging the first decocting liquid and the second decocting liquid, so that the volume of filtrate is reduced to 1/3, obtains concentrate;
Alum 20g and sodium bicarbonate 40g will be added in step 4 in concentrate, water supplement makes the weight 1000g of feed liquid, stands 24
Hour or more, supernatant is taken, supernatant is obtained;
Supernatant is concentrated step 5, obtains concentration clear liquid, adds emulsifier 17g, preservative 3g, surfactant 6g, thick
Regulator 17g is spent, heating, the temperature of heating is 60 DEG C, is uniformly dispersed, then let cool, adds water 70g, stir evenly.
Emulsifier is tristerin, and preservative is methylparaben, and surfactant is oleic acid polyethylene glycol glycerol
Ester, consistency modifiers are glycerol.
Embodiment 4
Difference with embodiment 3 is, in the step 2, when decoction also needs that magnesium sulfate 0.3g is added.
A kind of preparation method of the emulsifiable paste for soft tissue healing, comprises the following steps that
Step 1 takes ginkgo 1000g, adds water to cook, and decocts 2 times, and each amount of water is 3 times of the weight of ginkgo, and each decocts
Boiling the time is 3 hours, and merging filtrate after having decocted obtains the first decocting liquid;
Step 2 takes Radix Angelicae Sinensis 10g, adds water to cook, and magnesium sulfate 0.3g is added when decoction, decocts 2 times, each amount of water is Radix Angelicae Sinensis
3 times of weight, each decocting time is 2 hours, and merging filtrate after having decocted obtains the second decocting liquid;
Step 3 is concentrated after merging the first decocting liquid and the second decocting liquid, so that the volume of filtrate is reduced to 1/3, obtains concentrate;
Alum 20g and sodium bicarbonate 40g will be added in step 4 in concentrate, water supplement makes the weight 1000g of feed liquid, stands 24
Hour or more, supernatant is taken, supernatant is obtained;
Supernatant is concentrated step 5, obtains concentration clear liquid, adds emulsifier 17g, preservative 3g, surfactant 6g, thick
Regulator 17g is spent, heating, the temperature of heating is 60 DEG C, is uniformly dispersed, then let cool, adds water 70g, stir evenly.
Emulsifier is tristerin, and preservative is methylparaben, and surfactant is oleic acid polyethylene glycol glycerol
Ester, consistency modifiers are glycerol.
Embodiment 5
Difference with embodiment 4 is: in the step 2, after obtaining the second decocting liquid, and the ultrafiltration for being 200,000 with molecular cut off
Film is filtered, and takes filtrate.
A kind of preparation method of the emulsifiable paste for soft tissue healing, comprises the following steps that
Step 1 takes ginkgo 1000g, adds water to cook, and decocts 2 times, and each amount of water is 3 times of the weight of ginkgo, and each decocts
Boiling the time is 3 hours, and merging filtrate after having decocted obtains the first decocting liquid;
Step 2 takes Radix Angelicae Sinensis 10g, adds water to cook, and magnesium sulfate 0.3g is added when decoction, decocts 2 times, each amount of water is Radix Angelicae Sinensis
3 times of weight, each decocting time is 2 hours, merging filtrate after having decocted, and obtains the second decocting liquid, then with retaining molecule
Amount is filtered processing for 200,000 ultrafiltration membrane, and filtrate is taken to be sent into lower step process;
Step 3 is concentrated after merging the first decocting liquid and the second decocting liquid, so that the volume of filtrate is reduced to 1/3, obtains concentrate;
Alum 20g and sodium bicarbonate 40g will be added in step 4 in concentrate, water supplement makes the weight 1000g of feed liquid, stands 24
Hour or more, supernatant is taken, supernatant is obtained;
Supernatant is concentrated step 5, obtains concentration clear liquid, adds emulsifier 17g, preservative 3g, surfactant 6g, thick
Regulator 17g is spent, heating, the temperature of heating is 60 DEG C, is uniformly dispersed, then let cool, adds water 70g, stir evenly.
Emulsifier is tristerin, and preservative is methylparaben, and surfactant is oleic acid polyethylene glycol glycerol
Ester, consistency modifiers are glycerol.
Drug effect measurement detection
Assay: precision measures this product 5g and sets in 20ml measuring bottle, adds ethyl alcohol to be diluted to scale, shakes up, and filters, discards initial filter
Liquid collects subsequent filtrate as test solution.Berberine hydrochloride reference substance separately is taken, adds ethyl alcohol that every 1ml is made containing the molten of 0.04mg
Liquid, as reference substance solution.It is tested according to thin-layered chromatography, draws reference substance solution 2 μ l and 4 μ l, 2~3 μ l of test solution divides
Other point is expansion with benzene-ethyl acetate-methanol-isopropanol-water (6:3:1.5:1.5:0.3) on same silica gel g thin-layer plate
Isometric strong ammonia solution is added in another slot for agent, and after pre-equilibrating 15 minutes, ascending development 8cm takes out, dries, according to thin-layer chromatography
Method carries out fluorescent scanning, excitation wavelength, and: λ=366nm measures the integrated value of test sample and reference substance fluorescence intensity, calculates, i.e.,
?.The every 100g of this product is containing Radix Angelicae Sinensis with Berberine hydrochloride (C20H18ClNO4) calculate.
The granularity of emulsifiable paste is by the Pharmacopoeia of the People's Republic of China (version in 2010) second, and the first method of annex IXE is (micro-
Mirror method) measurement.
Detection data is as follows:
Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
Content of berberine hydrochloride in every 100g | 20.5g | 21.7g | 21.2g | 27.1g | 26.5 |
Granularity | ≤200μm | ≤200μm | ≤200μm | ≤120μm | ≤60μm |
As can be seen from the table, the active constituent content in the ointment that the present invention is prepared is high, adds sulphur by carrying out to Radix Angelicae Sinensis
After the extraction of sour magnesium, the extracted amount of active principle can be improved significantly, after the extracting solution of Radix Angelicae Sinensis is filtered,
The granularity that emulsifiable paste can be reduced significantly makes to apply covering more evenly.
Claims (8)
1. a kind of preparation method of the emulsifiable paste for soft tissue healing, comprises the following steps that
Step 1, by weight, takes 1000 parts of ginkgo, adds water to cook, obtain the first decocting liquid;
Step 2 takes 10 parts of Radix Angelicae Sinensis, adds water to cook, obtains the second decocting liquid;
Step 3 is concentrated after merging the first decocting liquid and the second decocting liquid, obtains concentrate;
20 parts of alum and 40 parts of sodium bicarbonate will be added in step 4 in concentrate, water supplement makes 1000 parts of weight of feed liquid, quiet
It sets 24 hours or more, takes supernatant, obtain supernatant;
Supernatant is concentrated step 5, obtains concentration clear liquid, adds 15~20 parts of emulsifier, 2~4 parts of preservative, surface work
Property 4~8 parts of agent, 12~20 parts of consistency modifiers, after heating, are uniformly dispersed, then let cool, add 50~100 parts of water, stir evenly,
?.
2. the preparation method of the emulsifiable paste according to claim 1 for soft tissue healing, it is characterised in that: described
It in step 1, decocts 2 times, each amount of water is 2~4 times of the weight of ginkgo, and each decocting time is 2~4 hours, is decocted
Merging filtrate after having boiled.
3. the preparation method of the emulsifiable paste according to claim 1 for soft tissue healing, it is characterised in that: described
It in step 2, decocts 2 times, each amount of water is 2~4 times of the weight of Radix Angelicae Sinensis, and each decocting time is 1~3 hour, is decocted
Merging filtrate after having boiled.
4. the preparation method of the emulsifiable paste according to claim 1 for soft tissue healing, it is characterised in that: described
In step 3, the step of concentration is that the volume of filtrate is made to be reduced to 1/3.
5. the preparation method of the emulsifiable paste according to claim 1 for soft tissue healing, it is characterised in that: described
In step 5, the temperature of heating is 50~70 DEG C.
6. the preparation method of the emulsifiable paste according to claim 1 for soft tissue healing, it is characterised in that: described
Emulsifier is tristerin, and the preservative is methylparaben, and the surfactant is oleic acid polyethylene glycol
Glyceride, the consistency modifiers are glycerol or propylene glycol.
7. the preparation method of the emulsifiable paste according to claim 1 for soft tissue healing, it is characterised in that: described
In step 2, when decoction, also needs to be added 0.3 part of magnesium sulfate.
8. the preparation method of the emulsifiable paste according to claim 1 for soft tissue healing, it is characterised in that: described
In step 2, after obtaining the second decocting liquid, it is filtered with the ultrafiltration membrane that molecular cut off is 200,000, takes filtrate.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108175767A (en) * | 2017-11-24 | 2018-06-19 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition is in the purposes of soft tissue injury |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108175767A (en) * | 2017-11-24 | 2018-06-19 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition is in the purposes of soft tissue injury |
CN108175767B (en) * | 2017-11-24 | 2020-03-31 | 江苏康缘药业股份有限公司 | Application of traditional Chinese medicine composition in soft tissue injury |
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