CN109010090A - A kind of sodium bicarbonate biological complex enzyme toothpaste - Google Patents
A kind of sodium bicarbonate biological complex enzyme toothpaste Download PDFInfo
- Publication number
- CN109010090A CN109010090A CN201811100105.9A CN201811100105A CN109010090A CN 109010090 A CN109010090 A CN 109010090A CN 201811100105 A CN201811100105 A CN 201811100105A CN 109010090 A CN109010090 A CN 109010090A
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- CN
- China
- Prior art keywords
- sodium bicarbonate
- complex enzyme
- biological complex
- toothpaste
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The present invention relates to a kind of sodium bicarbonate biological complex enzyme toothpaste, efficacy includes food grade saleratus and enzyme preparation, and the enzyme preparation includes muramidase and 1,4 beta-glucanase.The toothpaste be by rubbing agent, moisturizer, surfactant, thickener, acid-base buffer agent, food grade saleratus, enzyme preparation, taste-modifier, except stain whitening agent, essence, water are formulated by certain weight ratio.The sodium bicarbonate biological complex enzyme toothpaste utilizes the characteristics such as sodium bicarbonate particle alkalescent, diffusivity, permeability, strong cleaning force, go deep into teeth crevice, clean each position in oral cavity, help adjusts oral cavity acid-base balance, while can enhance the activity of the biological complex enzyme as main antimicrobial component, forms unique bacteriolyze Antibacterial Mechanism, effectively inhibit oral cavity harmful bacteria, bacterium attachment is reduced, dental plaque index is reduced, safeguards oral health jointly.
Description
Technical field
The present invention relates to oral cleaning nursing article technical fields, and in particular to a kind of sodium bicarbonate biological complex enzyme toothpaste.
Background technique
Sodium bicarbonate is a kind of excellent detergent, and itself has no toxic side effect, and sodium bicarbonate is utilized on domestic and international toothpaste market
Natural sex, alkalescent, particle friction the features such as, balance the pH value in oral cavity, inhibit acid plaque in oral cavity, when brushing teeth
Cleaning comprehensively is carried out to oral cavity to achieve the effect that except stain whitening, fresh breath.
Baking soda dentifrice currently on the market substitutes a part of conventional friction agent mainly using sodium bicarbonate as rubbing agent,
Although particle friction energy removes the tartar tooth stain of dental surface accumulation very well, sodium bicarbonate easily reacts production CO with water2, make cream
There are the wild effects such as flatulence, water outlet in body.Foam volume can be reduced by adding a large amount of sodium bicarbonate, and mouthfeel is partially salty, when influence is brushed teeth
Use feeling, while the crowd of mucous membrane of mouth breakage can be had damage.
Lysozyme mainly passes through the β in hydrolytic bacteria cell wall-Isosorbide-5-Nitrae glycosidic bond, destroys peptide glycan bracket, makees in osmotic pressure
Membranolysis is set to cause bacteria lysis dead under.Gram-positive bacteria cell wall outer layer is peptidoglycan layer, therefore lysozyme
There is preferable fungistatic effect to most of gram-positive bacterias, but the peptidoglycan layer of Gram-negative bacteria is located at cell inner wall
Layer, outer layer are covered with a large amount of lipopolysaccharides, and lysozyme is unsatisfactory to the fungistatic effect of most of Gram-negative bacterias.In recent years
That a part of lipopolysaccharides segment of cell surface can be dissolved out the study found that cell membrane agent interfering appropriate is added, promotes phosphatide
The outer layer of outer membrane is moved to, phosphatide replaces the lipopolysaccharides lost, further results in lipid from membrane translocation to supplement phosphatide, cell
Film loss of stability, so that lysozyme be made preferably to act on Gram-negative bacteria.
Summary of the invention
It is an object of the invention to solve the problems, such as it is in the prior art exist, a kind of sodium bicarbonate biological complex enzyme tooth is provided
Cream, the sodium bicarbonate biological complex enzyme toothpaste are deep using characteristics such as sodium bicarbonate particle alkalescent, diffusivity, permeability, cleaning force
Enter teeth crevice, cleans each position in oral cavity, help adjusts oral cavity acid-base balance, while can enhance as main antimicrobial component
The activity of biological complex enzyme forms unique bacteriolyze Antibacterial Mechanism, effectively inhibits oral cavity harmful bacteria, reduces bacterium attachment, drop
Low dental plaque index, safeguards oral health jointly.
To achieve the above object, technical solution of the present invention provides a kind of sodium bicarbonate biological complex enzyme toothpaste, the tooth
Cream contains efficacy, and the efficacy includes food grade saleratus and enzyme preparation, and the enzyme preparation includes murein
Enzyme and 1,4 beta-glucanase.
Its weight percent is food grade saleratus 0.1-5%, enzyme preparation 0.0002-0.02%.
The mass parts of the muramidase: the mass parts of 1,4 beta-glucanase are 1:0.4-0.6.
The composition of the sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component are as follows:
Rubbing agent 20-40%
Moisturizer 15-30%
Surfactant 0.5-3%
Thickener 0.5-2%
Acid-base buffer agent 0.2-1%
Food grade saleratus 0.1-5%
Enzyme preparation 0.0002-0.02%
Taste-modifier 0.01-0.5%
Except stain whitening agent 0.1-2%
Aromatic 0.5-2%
Water surplus.
Wherein the rubbing agent is at least one of hydrated silica, calcium monohydrogen phosphate, aluminium hydroxide.
Wherein the moisturizer is at least one of sorbierite, glycerol, propylene glycol, polyethylene glycol.
Wherein the surfactant is sodium lauroyl sarcosine, sodium lauroyl glutamate, Cocoamidopropyl betaine
At least one of.
Wherein the thickener is at least one of cellulose gum, hydroxypropyl guar gum, xanthan gum.
Wherein the acid-base buffer agent is at least one of sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate.
Wherein the taste-modifier is at least one of saccharin sodium, tri-chloro galactose type sugar, stevioside.
Wherein except stain whitening agent is at least one of sodium phytate, zinc citrate, calcium pyrophosphate.
The beneficial effects of the present invention are: on the basis of traditional baking soda dentifrice formula, the usage amount of sodium bicarbonate is reduced,
Its influence to lotion saline taste, foam volume, stability is reduced, the help of weak base performance adjusts oral cavity acid-base balance, it is right to resist acid
The erosion of tooth.Using biological complex enzyme as main antimicrobial component, the poly- peptide sugar of muramidase selective dissolution bacteria cell wall,
1,4 beta-glucanase decomposes the glucan that dental surface streptococcus mutans generate, and micro sodium bicarbonate can activate the antibacterial of biological enzyme living
Property, during lotion of toothpaste and Buccodental, gum CONTACT WITH FRICTION, promotes biological enzyme deeply to clean each position in oral cavity, have
Effect inhibits oral cavity harmful bacteria, reduces bacterium attachment, reduces dental plaque index, safeguard oral health jointly.
Sodium bicarbonate biological complex enzyme toothpaste of the present invention utilizes sodium bicarbonate particle alkalescent, diffusivity, permeability, strong cleaning force
Etc. characteristics, go deep into teeth crevice, clean each position in oral cavity, help adjusts oral cavity acid-base balance, while can enhance conduct mainly
The activity of the biological complex enzyme of antimicrobial component forms unique bacteriolyze Antibacterial Mechanism.
Specific embodiment
With reference to embodiment, the specific embodiment of the present invention is further described.Once embodiment is only used for more
Add and clearly demonstrate technical solution of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
The composition of sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component in embodiment 1 are as follows:
Hydrated silica 20%
Calcium monohydrogen phosphate 10%
Sorbierite 25%
Polyethylene glycol-400 15%
Sodium lauroyl sarcosine 1%
Cocoamidopropyl betaine 1%
Hydroxypropyl guar gum 0.6%
Cellulose gum 0.3%
Tertiary sodium phosphate 0.2%
Food grade saleratus 0.15%
Muramidase 0.001%
1,4 beta-glucanase 0.0006%
Tri-chloro galactose type sugar 0.15%
Zinc citrate 0.1%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 2
The composition of sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component in embodiment 2 are as follows:
Hydrated silica 20%
Aluminium hydroxide 10%
Sorbierite 30%
Propylene glycol 10%
Sodium lauroyl glutamate 1%
Cocoamidopropyl betaine 1%
Xanthan gum 0.6%
Cellulose gum 0.3%
Sodium dihydrogen phosphate 0.2%
Food grade saleratus 0.2%
Muramidase 0.005%
1,4 beta-glucanase 0.002%
Saccharin sodium 0.02%
Calcium pyrophosphate 0.1%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 3
The composition of sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component in embodiment 3 are as follows:
Hydrated silica 25%
Aluminium hydroxide 5%
Sorbierite 25%
Glycerol 10%
Sodium lauroyl glutamate 0.5%
Sodium lauroyl sarcosine 0.5%
Cocoamidopropyl betaine 1%
Hydroxypropyl guar gum 0.6%
Xanthan gum 0.5%
Tetrasodium pyrophosphate 0.5%
Food grade saleratus 0.25%
Muramidase 0.01%
1,4 beta-glucanase 0.05%
Stevioside 0.1%
Sodium phytate 0.3%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Comparative example 1
Comparative example 1 and the difference of embodiment 3 are only that: the additive amount of food grade saleratus is 5%.
Comparative example 2 and the difference of embodiment 3 are only that: being free of food grade saleratus.
Comparative example 3 and the difference of embodiment 3 are only that: being free of muramidase and 1,4 beta-glucanase.
Comparative example 4 and the difference of embodiment 3 are only that: being free of muramidase.
Comparative example 5 and the difference of embodiment 3 are only that: being free of 1,4 beta-glucanase.
Using sodium bicarbonate biological complex enzyme toothpaste performance test methods prepared by the present invention are as follows:
1, physical and chemical index and estimation of stability
Sodium bicarbonate biological complex enzyme toothpaste in embodiment and comparative example is detected by GB/T 8372, evaluates its stability.
2, fungistatic effect is evaluated
Gram-positive bacteria enterococcus faecalis and Gram-negative bacteria Porphyromonas endodontalis in vitro are chosen as experimental strain, observes little Su
It beats and bacteriostasis is cooperateed with to enterococcus faecalis and Porphyromonas endodontalis in vitro with compound biological enzyme.
The above results explanation, the sodium bicarbonate of low content do not influence the stability of lotion of toothpaste, and the sodium bicarbonate of high-content can be broken
The stability of bad lotion of toothpaste；Two kinds of enzyme compoundings are than having more significant fungistatic effect using single enzyme preparation；It adds in right amount small
Soda can rise with compound biological enzyme and cooperate with bacteriostasis, but can inhibit the bacteriostatic activity of biological enzyme when too high levels.
Claims (10)
1. a kind of sodium bicarbonate biological complex enzyme toothpaste, which is characterized in that the toothpaste contains efficacy, effect combination
Object includes food grade saleratus and enzyme preparation, and the enzyme preparation includes muramidase and 1,4 beta-glucanase.
2. sodium bicarbonate biological complex enzyme toothpaste according to claim 1, which is characterized in that the food grade saleratus
0.1-5%, enzyme preparation 0.0002-0.02%.
3. according to claim 1 or sodium bicarbonate biological complex enzyme toothpaste described in 2, which is characterized in that the muramidase
Mass parts: the mass parts of 1,4 beta-glucanase are 1:0.4-0.6.
4. sodium bicarbonate biological complex enzyme toothpaste according to claim 3, which is characterized in that the sodium bicarbonate biological complex enzyme
The composition of toothpaste and the weight percent of component are as follows:
Rubbing agent 20-40%
Moisturizer 15-30%
Surfactant 0.5-3%
Thickener 0.5-2%
Acid-base buffer agent 0.2-1%
Food grade saleratus 0.1-5%
Enzyme preparation 0.0002-0.02%
Taste-modifier 0.01-0.5%
Except stain whitening agent 0.1-2%
Aromatic 0.5-2%
Water surplus.
5. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the rubbing agent is hydration silicon
At least one of stone, calcium monohydrogen phosphate, aluminium hydroxide.
6. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the moisturizer is sorb
At least one of alcohol, glycerol, propylene glycol, polyethylene glycol.
7. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the surfactant is the moon
At least one of osmanthus acylsarcosine sodium, sodium lauroyl glutamate, Cocoamidopropyl betaine.
8. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the thickener is cellulose
At least one of glue, hydroxypropyl guar gum, xanthan gum.
9. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the acid-base buffer agent is coke
At least one of sodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate.
10. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the taste-modifier is
At least one of saccharin sodium, tri-chloro galactose type sugar, stevioside；The stain whitening agent that removes is sodium phytate, zinc citrate, calcium pyrophosphate
At least one of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811100105.9A CN109010090A (en) | 2018-09-20 | 2018-09-20 | A kind of sodium bicarbonate biological complex enzyme toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811100105.9A CN109010090A (en) | 2018-09-20 | 2018-09-20 | A kind of sodium bicarbonate biological complex enzyme toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109010090A true CN109010090A (en) | 2018-12-18 |
Family
ID=64617169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811100105.9A Pending CN109010090A (en) | 2018-09-20 | 2018-09-20 | A kind of sodium bicarbonate biological complex enzyme toothpaste |
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| CN (1) | CN109010090A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110547977A (en) * | 2019-08-30 | 2019-12-10 | 广州悦创实业有限公司 | oral care composition containing baking soda as well as preparation method and application thereof |
| CN111643384A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | Biological enzyme oral cleaning and nursing toothpaste |
| US11168287B2 (en) | 2016-05-26 | 2021-11-09 | Kimberly-Clark Worldwide, Inc. | Anti-adherent compositions and methods of inhibiting the adherence of microbes to a surface |
| CN113813197A (en) * | 2021-10-29 | 2021-12-21 | 重庆登康口腔护理用品股份有限公司 | Composition for improving antibacterial activity and application thereof in oral products |
| WO2022020698A1 (en) * | 2020-07-24 | 2022-01-27 | Colgate-Palmolive Company | Oral care compositions containing sodium lauroyl sarcosinate and betaine |
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|---|---|---|---|---|
| CN1861039A (en) * | 2006-04-14 | 2006-11-15 | 张少辉 | Chewing bubble-producing type solid tooth-paste |
| CN101721324A (en) * | 2010-01-14 | 2010-06-09 | 江苏雪豹日化有限公司 | Biological complex enzyme toothpaste and preparation method thereof |
| CN104546535A (en) * | 2015-01-06 | 2015-04-29 | 韩俊峰 | Active lytic enzyme for improving effects of toothpaste, detergent and cleaning agent |
| CN105326708A (en) * | 2015-11-25 | 2016-02-17 | 王晓伟 | Notoginseng whitening toothpaste |
-
2018
- 2018-09-20 CN CN201811100105.9A patent/CN109010090A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861039A (en) * | 2006-04-14 | 2006-11-15 | 张少辉 | Chewing bubble-producing type solid tooth-paste |
| CN101721324A (en) * | 2010-01-14 | 2010-06-09 | 江苏雪豹日化有限公司 | Biological complex enzyme toothpaste and preparation method thereof |
| CN104546535A (en) * | 2015-01-06 | 2015-04-29 | 韩俊峰 | Active lytic enzyme for improving effects of toothpaste, detergent and cleaning agent |
| CN105326708A (en) * | 2015-11-25 | 2016-02-17 | 王晓伟 | Notoginseng whitening toothpaste |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11168287B2 (en) | 2016-05-26 | 2021-11-09 | Kimberly-Clark Worldwide, Inc. | Anti-adherent compositions and methods of inhibiting the adherence of microbes to a surface |
| CN110547977A (en) * | 2019-08-30 | 2019-12-10 | 广州悦创实业有限公司 | oral care composition containing baking soda as well as preparation method and application thereof |
| CN110547977B (en) * | 2019-08-30 | 2022-07-15 | 广州悦创实业有限公司 | Oral care composition containing baking soda as well as preparation method and application thereof |
| WO2022020698A1 (en) * | 2020-07-24 | 2022-01-27 | Colgate-Palmolive Company | Oral care compositions containing sodium lauroyl sarcosinate and betaine |
| US20220023180A1 (en) * | 2020-07-24 | 2022-01-27 | Colgate-Palmolive Company | Oral Care Compositions Containing Sodium Lauroyl Sarcosinate and Betaine |
| CN111643384A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | Biological enzyme oral cleaning and nursing toothpaste |
| CN113813197A (en) * | 2021-10-29 | 2021-12-21 | 重庆登康口腔护理用品股份有限公司 | Composition for improving antibacterial activity and application thereof in oral products |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181218 |
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