CN108992445A - Two kinds of anti-tumor drug micrometer fibers films of a kind of load and preparation method thereof - Google Patents
Two kinds of anti-tumor drug micrometer fibers films of a kind of load and preparation method thereof Download PDFInfo
- Publication number
- CN108992445A CN108992445A CN201810918459.8A CN201810918459A CN108992445A CN 108992445 A CN108992445 A CN 108992445A CN 201810918459 A CN201810918459 A CN 201810918459A CN 108992445 A CN108992445 A CN 108992445A
- Authority
- CN
- China
- Prior art keywords
- micrometer fibers
- kinds
- egcg
- plga
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses one kind be loaded with the antitumor micrometer fibers film of Epigallo-catechin gallate (EGCG) (Epigallocatechin gallate, EGCG) and camptothecine (Camptothecin, CPT) with and preparation method thereof.Antitumor cell effect is up to 80%.The micrometer fibers film is made of anti-tumor drug and polymer base material, and drug ingedient therein is EGCG and CPT, and the matrix of micrometer fibers film is a kind of biodegradable high molecular material.The preparation method, the specific steps are that: by EGCG, CPT and Biodegradable polymer material are added in organic solvent, obtain spinning solution, carry out electrostatic spinning using electrostatic electric spinning instrument, volatile organic solvent is just made.Effect is lasting for micrometer fibers film inhibition tumour cell of drug there are two types of carrying in this, and preparation is easy, and application prospect is wide.
Description
Technical field
The invention belongs to micron pharmaceutical carrier technical fields, and in particular to a kind of two kinds of anti-tumor drug micrometer fibers films of load
And preparation method thereof.
Background technique
Tumour affects countless patients as common and multiple fatal disease.That clinically copes at present is common
Treatment means have operation, radiotherapy, chemotherapy etc..Wherein, chemotherapy is common clinical treatment means.But traditional change
Learning therapy has strong side effect to the histocyte of health, and human body is made the symptoms such as alopecia, bone marrow suppression, catarrh occur.It is existing
Nowadays, the significant challenge that chemotherapy faces is: how to design the transmission system that can effectively and safely deliver drug.
Implantable drug delivery system, which is applied, can be traced earliest in antitumor field to mid-term the 1970s, and research is found
Tumor locus active drug concentration can be improved in chemotherapeutics controlled release agent, extends the time of tumor contact drug, drug can be made to reach
The position that conventional administration mode is unable to reach, and can be reduced due to the caused toxic side effect that is administered systemically.Herein it is proposed that one
The implantable drug delivery system of a Drug controlled release, it can not only realize the characteristic of above-mentioned chemotherapeutics controlled release agent, moreover it is possible to drop
The rate of release of low drug, so that drug tends to constant release in human body.It is maximum excellent compared to traditional chemotherapeutics
Point is that toxic side effect is lower, and therapeutic efficiency is higher.
Poly lactide-glycolide acid (Polylactic-co- glycolic acid, PLGA) it is a kind of with good
Biocompatibility and mechanical property material, and combine the high intensity of PLA and the high degradation speed of PGA, degradation speed
Rate can obtain adjusting control by changing the ratio of PGA and PLA.Then, we are using PLGA as epigallocatechin
The carrier material of gallate (Epigallocatechin gallate, EGCG) and camptothecine (Camptothecin, CPT)
Material.This kind of fiber membrane carrier, can make the rate of release of drug be controlled, and avoid excessive concentration and break out asking for release
Topic, while can also reach the proliferation for effectively inhibiting tumour, kill the purpose of cancer cell.
Electrostatic spinning is a kind of special fiber fabrication process, principle be by polymer solution or melt in strong electrical field into
Row jet spinning.Under electric field action, the drop at syringe needle can be become conical (i.e. " taylor cone ") from spherical shape, and from epiconus
End, which is extended, obtains fiber filaments, and such fiber filaments have the diameter of micron dimension.The micron as synthesized by PLGA material is fine
Tieing up filament has great specific surface area and excellent biocompatibility, and as the matrix for carrying medicine, it can be by drug substance stable
It is delivered to human body privileged sites and maintains the concentration of drug.Therefore, degradable macromolecule fiber is a kind of ideal medicament slow release
Material.
The report that electrospinning fibre is applied to drug controlled release is come across 2002 earliest, by Ignatious and
Two people of Baldoni proposes that the drug release of composite drug can be by Electrospun fibre in a United States Patent (USP) (US20020181640)
Dimension regulation, obtains the medicament of different rate of releasing drug.
Summary of the invention
In view of this, the purpose of the invention is to provide the antitumor tunica fibrosas for carrying two kinds of drugs；The purpose of the present invention
Two be to provide the preparation method of above-mentioned drug-loading fibre film.
To achieve the above object, using following scheme:
1. a kind of two kinds of anti-tumor drug micrometer fibers films of load, which is characterized in that include two kinds of anti-tumor drugs and micrometer fibers
Film matrix two parts, the ingredient of two kinds of anti-tumor drugs are Epigallo-catechin gallate (EGCG)
(Epigallocatechin gallate, EGCG) and camptothecine (Camptothecin, CPT), the micrometer fibers film base
Body is made of Biodegradable polymer material, and the Biodegradable polymer material is poly lactic-co-glycolic acid copolymerization
Object (Polylactic-co- glycolic acid, PLGA).
Further, the mass ratio of the EGCG and CPT is 1:5~5:1；Two kinds of anti-tumor drugs and micron
The mass ratio of tunica fibrosa matrix is 1:10~1:20.
Further, the Biodegradable polymer material is PLGA, the ratio of LA and GA in the PLGA
For 4:1 ~ 1:4, the molecular weight of the PLGA is 1~100,000.
The preparation method of two kinds of anti-tumor drug micrometer fibers films of a kind of load described in 2., which is characterized in that comprising as follows
Step:
(1) EGCG, CPT and PLGA are dissolved in organic solvent, vortex is allowed to be uniformly dissolved, and is configured to high polymer electrospinning liquid；
The organic solvent is the mixed liquor of the methylene chloride that volume ratio is 5:5~8:2 and methanol；
(2) under conditions of temperature is 25 degrees Celsius and relative humidity is 30~50%, using aluminium-foil paper as receiver, Static Spinning is used
High polymer electrospinning liquid is carried out spinning by silk instrument, and a kind of two kinds of anti-tumor drug micrometer fibers films of load are made in volatile organic solvent, from
It is stored in -20 degrees Celsius of closed container after so air-drying.
Further, the mass fraction of PLGA is 15% in the high polymer electrospinning liquid of the step (1).
Further, in the step (2) electrostatic spinning machine use parameter are as follows: 3 V of input voltage, output voltage 10
KV, receives 6~8 cm of distance, and the volume of high polymer electrospinning liquid is 2 mL, 0.35 mL/min of spinning fltting speed, and spinning nozzle is straight
0.51 mm of diameter.
Compared with the prior art, the present invention has the advantages that
The invention discloses two kinds of anti-tumor drug micrometer fibers films of a kind of load and preparation method thereof, and the micrometer fibers film is as one
The completely new antineoplastic drug carrier of kind, with excellent biocompatibility and biodegradability, drug is from carrier material
Release slowly and can regulate and control, the concentration of drug is stablized, and has good inhibition growth of tumour cell, kills cancer cell
Effect.80% or more can reach to the inhibitory effect of CT26 mouse cancer cell.
Preparation method of the present invention is simple, easy to operate using electrostatic spinning machine, environmentally friendly.
Detailed description of the invention
Fig. 1 is the electron scanning micrograph and diameter point of two kinds of anti-tumor drug micrometer fibers films of load of embodiment 1
Cloth.
Fig. 2 is rejection of the two kinds of anti-tumor drug micrometer fibers films of load to colon tumor cell of embodiment 1.
Specific embodiment
Below in conjunction with attached drawing, a preferred embodiment of the present invention will be described in detail.
Embodiment 1
600 mg PLGA (molecular weight is 4.4 ten thousand) is accurately weighed with balance, is dissolved in methylene chloride and methanol (volume
Ratio is 8:2) in the mixed solvent, make PLGA mass concentration 15%, seal bottleneck to prevent solvent from volatilizing.With vortex instrument whirlpool
It is threaded to be completely dissolved to get spinning solution.Under the conditions of 25 degrees Celsius, 30~50 % of relative humidity, using aluminium-foil paper as receiver,
Spinning is carried out to electrospinning liquid with electrostatic spinning machine.3 V of input voltage, 10 KV of output voltage receive 8 cm of distance, electrospinning liquid 2
ML, 0.35 mL/min of spinning solution fltting speed, 0.51 mm of spinning nozzle diameter.After aeration-drying, micrometer fibers film is obtained, it is entitled
Blank micrometer fibers film PLGA.The PLGA shown in FIG. 1 electron scanning micrograph of blank micrometer fibers film and its straight thus
The case where diameter is distributed.
The sample preparation for choosing five groups of differences EGCG and CPT again carries two kinds of anti-tumor drug micrometer fibers films.Wherein every group
PLGA be 600 mg, the gross mass of every group of drug is 60 mg.The mass ratio of five groups of drug EGCG:CPT is respectively 1:0,0:
1,2:1,1:1,1:2 .It is dissolved in the in the mixed solvent of methylene chloride and methanol (volume ratio 8:2), makes PLGA mass
Concentration is 15%, seals bottleneck to prevent solvent from volatilizing.It is vortexed with vortex instrument to being completely dissolved to get spinning solution.At 25 degree,
Under the conditions of relative humidity 30~50%, using aluminium-foil paper as receiver, spinning is carried out to electrospinning liquid with electrostatic spinning machine.Input voltage
3V, 10 KV of output voltage, receive 8 cm of distance, 2 mL of electrospinning liquid, 0.35 mL/min of spinning solution fltting speed, and spinning nozzle is straight
0.51 mm of diameter.After aeration-drying, two kinds of drug micrometer fibers films of load of five kinds of difference EGCG and CPT ratios, pattern difference are obtained
PLGA-CPT, PLGA-EGCG, PLGA-EGCG/CPT (2:1), PLGA-EGCG/CPT (1:1), PLGA-EGCG/ such as Fig. 1
Shown in CPT (1:2).
Application Example
It is as follows to the inhibiting effect test of mouse junction cancer CT-26 cell in-vitro growth to carry medicine micrometer fibers film:
Subject cell: mouse junction cancer CT-26 cell；
Subject material: two kinds of anti-tumor drug micrometer fibers films are carried；
Experimental method: two kinds of anti-tumor drug micrometer fibers films PLGA, PLGA-CPT, PLGA-EGCG, PLGA-EGCG/ will be carried
CPT (2:1), PLGA-EGCG/CPT (1:1), PLGA-EGCG/CPT (1:2) (having a size of the cm of 1 cm × 1) ultraviolet sterilization.It will be micro-
Rice tunica fibrosa is placed in 24 orifice plates, 800 μ L serum free mediums is added, prewet 1 h.Cell in logarithmic growth phase is used
It is 1 × 10 with complete medium adjustment cell concentration after pancreatin digestion5/ mL is added in 24 orifice plates, in 37 degree, 5 % CO2
Incubator in cultivate 24 h.3 multiple holes are set.After culture, culture medium and micrometer fibers film are discarded, every hole adds MTT molten
Liquid (0.5 mg/mL) 1 mL.Continue after cultivating 4 h, discards cell supernatant, every hole adds 600 μ L of dimethyl sulfoxide, sets shaking table
Upper 10~20 min of low-speed oscillation, dissolves crystal violet sufficiently.In the extinction that microplate reader OD value is each hole of measurement at 570 nm
It spends (A570), test repeats 3 times, calculates separately the relative activity of tumour cell.As shown in Fig. 2, to carry medicine micrometer fibers film
In the antitumor cell performance for cultivating 24 h.
The results showed that carrying the micrometer fibers film of EGCG and CPT has apparent inhibition to mouse junction cancer CT-26 cell
Effect, two kinds of drugs have preferable two kinds of therapeutic effects, better than the therapeutic effect of single medicine.
Finally, it is stated that above embodiments are only used to illustrate technical solution of the present invention rather than limit, although passing through ginseng
According to the preferred embodiment of the present invention, invention has been described, it should be appreciated by those of ordinary skill in the art that can
To make various changes to it in the form and details, without departing from the present invention defined by the appended claims
Spirit and scope.
Claims (4)
1. a kind of two kinds of anti-tumor drug micrometer fibers films of load, which is characterized in that include two kinds of anti-tumor drugs and micrometer fibers
Film matrix two parts, the ingredient of two kinds of anti-tumor drugs are Epigallo-catechin gallate (EGCG)
(Epigallocatechin gallate, EGCG) and camptothecine (Camptothecin, CPT), the micrometer fibers film base
Body is made of Biodegradable polymer material, and the Biodegradable polymer material is poly lactic-co-glycolic acid copolymerization
Object (Polylactic-co- glycolic acid, PLGA)；A kind of system of two kinds of anti-tumor drug micrometer fibers films of load
Preparation Method, which is characterized in that comprise the following steps:
(1) EGCG, CPT and PLGA are dissolved in organic solvent, vortex is allowed to be uniformly dissolved, and is configured to high polymer electrospinning liquid；
The organic solvent is the mixed liquor of the methylene chloride that volume ratio is 5:5~8:2 and methanol；
(2) under conditions of temperature is 25 degrees Celsius and relative humidity is 30~50%, using aluminium-foil paper as receiver, Static Spinning is used
High polymer electrospinning liquid is carried out spinning by silk instrument, and a kind of two kinds of anti-tumor drug micrometer fibers films of load are made in volatile organic solvent, from
It is stored in -20 degrees Celsius of closed container after so air-drying.
2. a kind of two kinds of anti-tumor drug micrometer fibers films of load according to claim 1, which is characterized in that the EGCG
Mass ratio with CPT is 1:5~5:1；The mass ratio of two kinds of anti-tumor drugs and micrometer fibers film matrix be 1:10~
1:20；The Biodegradable polymer material is PLGA, and the ratio of LA and GA in the PLGA are 4:1 ~ 1:4, institute
The molecular weight of the PLGA stated is 1~100,000.
3. a kind of preparation method for carrying two kinds of anti-tumor drug micrometer fibers films according to claim 1, it is characterised in that:
The mass fraction of PLGA is 15% in the high polymer electrospinning liquid of the step (1).
4. a kind of preparation method for carrying two kinds of anti-tumor drug micrometer fibers films according to claim 1, feature exist
In: the use parameter of electrostatic spinning machine in the step (2) are as follows: 3 V of input voltage, 10 KV of output voltage, reception distance 6~
8 cm, the volume of high polymer electrospinning liquid are 2 mL, 0.35 mL/min of spinning fltting speed, 0.51 mm of spinning nozzle diameter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810918459.8A CN108992445A (en) | 2018-08-14 | 2018-08-14 | Two kinds of anti-tumor drug micrometer fibers films of a kind of load and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810918459.8A CN108992445A (en) | 2018-08-14 | 2018-08-14 | Two kinds of anti-tumor drug micrometer fibers films of a kind of load and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108992445A true CN108992445A (en) | 2018-12-14 |
Family
ID=64596633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810918459.8A Pending CN108992445A (en) | 2018-08-14 | 2018-08-14 | Two kinds of anti-tumor drug micrometer fibers films of a kind of load and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108992445A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908107A (en) * | 2019-02-27 | 2019-06-21 | 广东省医疗器械研究所 | A kind of load antibacterials beading nano fibrous membrane and preparation method thereof |
| CN112546284A (en) * | 2020-12-22 | 2021-03-26 | 南通大学 | Degradable photothermal/chemotherapeutic synergistic anti-tumor fiber dressing |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552265A (en) * | 2010-12-23 | 2012-07-11 | 复旦大学 | Medicinal composition containing epigallocatechin gallate and camptothecin |
| US9180226B1 (en) * | 2014-08-07 | 2015-11-10 | Cook Medical Technologies Llc | Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof |
| CN106727447A (en) * | 2016-12-30 | 2017-05-31 | 西南大学 | A kind of preparation method for loading antineoplastic beading nano fibrous membrane |
| CN107308136A (en) * | 2017-07-05 | 2017-11-03 | 西南大学 | A kind of carrying anti-tumor medicine electrospinning micrometer fibers film and preparation method thereof |
-
2018
- 2018-08-14 CN CN201810918459.8A patent/CN108992445A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552265A (en) * | 2010-12-23 | 2012-07-11 | 复旦大学 | Medicinal composition containing epigallocatechin gallate and camptothecin |
| US9180226B1 (en) * | 2014-08-07 | 2015-11-10 | Cook Medical Technologies Llc | Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof |
| CN106727447A (en) * | 2016-12-30 | 2017-05-31 | 西南大学 | A kind of preparation method for loading antineoplastic beading nano fibrous membrane |
| CN107308136A (en) * | 2017-07-05 | 2017-11-03 | 西南大学 | A kind of carrying anti-tumor medicine electrospinning micrometer fibers film and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908107A (en) * | 2019-02-27 | 2019-06-21 | 广东省医疗器械研究所 | A kind of load antibacterials beading nano fibrous membrane and preparation method thereof |
| CN109908107B (en) * | 2019-02-27 | 2022-07-08 | 广东省医疗器械研究所 | Antibacterial drug-loaded beaded nanofiber membrane and preparation method thereof |
| CN112546284A (en) * | 2020-12-22 | 2021-03-26 | 南通大学 | Degradable photothermal/chemotherapeutic synergistic anti-tumor fiber dressing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mohammadian et al. | Drug loading and delivery using nanofibers scaffolds | |
| Yang et al. | From nano to micro to macro: Electrospun hierarchically structured polymeric fibers for biomedical applications | |
| Zamani et al. | Advances in drug delivery via electrospun and electrosprayed nanomaterials | |
| Buzgo et al. | Blend electrospinning, coaxial electrospinning, and emulsion electrospinning techniques | |
| Eatemadi et al. | Nanofiber: Synthesis and biomedical applications | |
| Iqbal et al. | Encapsulation of anticancer drugs (5-fluorouracil and paclitaxel) into polycaprolactone (PCL) nanofibers and in vitro testing for sustained and targeted therapy | |
| Mickova et al. | Core/shell nanofibers with embedded liposomes as a drug delivery system | |
| Luo et al. | Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation | |
| Agrahari et al. | Electrospun nanofibers in drug delivery: fabrication, advances, and biomedical applications | |
| Li et al. | Co-delivery of dexamethasone and green tea polyphenols using electrospun ultrafine fibers for effective treatment of keloid | |
| CN107308136A (en) | A kind of carrying anti-tumor medicine electrospinning micrometer fibers film and preparation method thereof | |
| Gao et al. | The implantable 5-fluorouracil-loaded poly (l-lactic acid) fibers prepared by wet-spinning from suspension | |
| CN108992432A (en) | Non-woven membrane as drug delivery system | |
| Wang et al. | Local in vitro delivery of rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment | |
| Varshosaz et al. | Poly (butylene adipate-co-terephthalate) electrospun nanofibers loaded with 5-fluorouracil and curcumin in treatment of colorectal cancer cells | |
| Pásztor et al. | Preparation and characterization of levofloxacin-loaded nanofibers as potential wound dressings | |
| CN101843578B (en) | Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof | |
| Liu et al. | Polycaprolactone nanofibres loaded with 20 (S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study | |
| CN106727447A (en) | A kind of preparation method for loading antineoplastic beading nano fibrous membrane | |
| CN108992445A (en) | Two kinds of anti-tumor drug micrometer fibers films of a kind of load and preparation method thereof | |
| CN102688223B (en) | Anti-cancer drug-loading nanofiber film and preparation method thereof | |
| Yang et al. | Application of electrospun drug-loaded nanofibers in cancer therapy | |
| Syed et al. | A review on current trends and future prospectives of electrospun biopolymeric nanofibers for biomedical applications | |
| Yousefnezhad et al. | PCL-based nanoparticles for doxorubicin-ezetimibe co-delivery: A combination therapy for prostate cancer using a drug repurposing strategy | |
| Lee et al. | Enhancing the anti-bacterial activity of nanofibrous polyurethane membranes by incorporating glycyrrhizic acid-conjugated β-Cyclodextrin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181214 |
|
| WD01 | Invention patent application deemed withdrawn after publication |