CN108982832A - A kind of immunodiagnosis detection device - Google Patents
A kind of immunodiagnosis detection device Download PDFInfo
- Publication number
- CN108982832A CN108982832A CN201811140223.2A CN201811140223A CN108982832A CN 108982832 A CN108982832 A CN 108982832A CN 201811140223 A CN201811140223 A CN 201811140223A CN 108982832 A CN108982832 A CN 108982832A
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- Prior art keywords
- matrix
- detection device
- reaction vessel
- holding portion
- water
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- 238000001514 detection method Methods 0.000 title claims abstract description 40
- 239000011159 matrix material Substances 0.000 claims abstract description 42
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 5
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims description 39
- 239000000463 material Substances 0.000 claims description 7
- 230000001745 anti-biotin effect Effects 0.000 claims description 5
- 230000006287 biotinylation Effects 0.000 claims description 5
- 238000007413 biotinylation Methods 0.000 claims description 5
- 108010090804 Streptavidin Proteins 0.000 claims description 3
- 239000012466 permeate Substances 0.000 claims description 2
- 230000009870 specific binding Effects 0.000 claims description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims 1
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- 235000014103 egg white Nutrition 0.000 claims 1
- 210000000969 egg white Anatomy 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 15
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 9
- 238000012360 testing method Methods 0.000 abstract description 6
- 239000002250 absorbent Substances 0.000 abstract description 2
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 description 9
- 102000036639 antigens Human genes 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 9
- 239000007790 solid phase Substances 0.000 description 6
- 239000007791 liquid phase Substances 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 2
- 108091006004 biotinylated proteins Proteins 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 230000036632 reaction speed Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000006379 syphilis Diseases 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 241000589884 Treponema pallidum Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses a kind of immunodiagnosis detection devices, belong to technical field of pharmaceutical biotechnology.Immunodiagnosis detection device of the present invention includes matrix and water-holding portion, and protein matter is coated on matrix, and absorbent section is below matrix, and water-holding portion is for absorbing the liquid permeated down from matrix.Detection device provided by the invention, the water-holding portion being located at below matrix is set, water-holding portion can absorb the excess reagent being added in the operation such as cleaning in the detection process, and cleaning solution need to only be added dropwise on matrix when carrying out and the operation such as cleaning, structure is simple, the complex operations for being added, extracting out cleaning solution repeatedly are eliminated, operation is easier, more save the time, detection efficiency is higher and pollution risk is small, testing result is more reliable.
Description
Technical field
The present invention relates to technical field of pharmaceutical biotechnology more particularly to a kind of immunodiagnosis detection devices.
Background technique
Immunodiagnosis device on the market in the detection process, carries out that movement is cleaned multiple times, process is extremely numerous at present
Trivial, cleaning operation did not at that time have a significant impact to testing result, and imbibition liquid feeding process repeatedly may also increase the risk of pollution.
In addition, the used coated antibody or the solid phase of antigen of being used for is ELISA Plate, magnetic in existing immunodiagnosis device
Pearl, film item etc., production technology is complex；Solid phase on the market after the completion of reaction detector detection-phase design also simultaneously
Unreasonable, the accuracy of detector detection is irregular；The existing reaction time is very long, increases the time of testing result output；
General solid phase has been coated with the protein matters such as specific antigen or antibody in production, and versatility is very poor.
Summary of the invention
It is an object of the invention to propose a kind of immunodiagnosis detection device easy to operate.
To achieve this purpose, the present invention adopts the following technical scheme:
A kind of immunodiagnosis detection device, comprising:
Matrix is coated with protein matter thereon；And
Water-holding portion is located at below described matrix, and the water-holding portion is for absorbing the liquid permeated down from described matrix
Body.
Further, described matrix is made of porous filter material.
It further, further include reaction vessel, described matrix and the water-holding portion are set in the reaction vessel, described
Reaction vessel has opening, and the opening is located at the top of the reaction vessel and is located at the surface of described matrix.
Further, the opening is funnel-shaped.
Further, the profile of the outside wall surface of the detector of the profile and detector of the inner wall of the opening matches.
Further, the bottom of the reaction vessel is provided with aperture.
Further, the reaction vessel includes ontology and the lid that is removable installed on the ontology, described to open
Mouth is set to the top of the lid.
Further, the outside of the ontology of the reaction vessel is provided with positioning region.
Further, the positioning region is annular in shape.
Further, it is coated with anti-biotin antibodies or streptavidin in described matrix, is used for and is added
Biotinylated protein matter specific binding in described matrix.
Beneficial effects of the present invention are as follows:
Detection device provided by the invention, setting are located at the water-holding portion below matrix, and structure is simple, and water-holding portion can inhale
The excess reagent instilled in the operation such as cleaning in the detection process is received, and need to only be dripped on matrix when carrying out and the operation such as cleaning
Add cleaning solution, eliminate the complex operations for being added, extracting out cleaning solution repeatedly, operates easier, more saving time, detection effect
Rate is higher and pollution risk is small, testing result is more reliable.
Detailed description of the invention
Fig. 1 is the axonometric drawing for the immunodiagnosis detection device that the specific embodiment of the invention provides；
Fig. 2 is the exploded view for the immunodiagnosis detection device that the specific embodiment of the invention provides；
Fig. 3 is the bottom view for the immunodiagnosis detection device that the specific embodiment of the invention provides；
Fig. 4 is the top view for the immunodiagnosis detection device that the specific embodiment of the invention provides；
Fig. 5 is the main view for the immunodiagnosis detection device that the specific embodiment of the invention provides；
Fig. 6 is the side view for the immunodiagnosis detection device that the specific embodiment of the invention provides.
Appended drawing reference:
10, reaction vessel；20, matrix；30, water-holding portion；40, positioning region；11, ontology；12, lid；111, aperture；121,
Opening；122, snap ring.
Specific embodiment
To further illustrate the technical scheme of the present invention below with reference to the accompanying drawings and specific embodiments.
As depicted in figs. 1 and 2, a specific embodiment of the invention provides a kind of immunodiagnosis detection device, packet
The matrix 20 and water-holding portion 30 for including reaction vessel 10 and being set in reaction vessel 10.Opening is provided on reaction vessel 10
121, it preferably but is not limited to be coated with anti-biotin antibodies on matrix 20, water-holding portion 30 is set to 20 lower section of matrix and by absorbing water
Material is made, and water-holding portion 30 is used to absorb during the liquid permeated down from matrix 20, such as 30 absorption detecting of water-holding portion
The cleaning solution etc. of addition.Its split shed 121 is preferably located at the surface of matrix 20, matrix 20 be located at water-holding portion 30 just on
Side.Wherein, reaction vessel 10 is preferred but is not limited to be made of plastic materials such as polyethylene, polypropylene.Water-holding portion 30 preferably but
It is not limited to cylindrical.Water-absorbent material is preferred but is not limited to acetyl fibre, and papery can be set in the lateral surface of acetyl fibre
Wrapping layer.Reaction vessel 10 is preferred but is not limited to include ontology 11 to open with the lid 12 being removable installed on ontology 11
Mouth 121 is set to the top of lid 12.Lid 12 can be connected in the upper of ontology 11 by being fixedly arranged on the snap ring 122 of its bottom
End.In present embodiment, snap ring 122 is arranged in the upper end inner circumferential of ontology 11, in other embodiments, can also enable snap ring
122 are arranged in the upper end periphery of ontology 11.It should be noted that in other embodiments, being also possible to wrap on the base 20
By any protide antibody such as streptavidin or antigen.It should be noted that in other specific embodiments
It can be not provided with reaction vessel 10.
The detection device that present embodiment provides, setting are located at the water-holding portion 30 of 20 lower section of matrix, and structure is simple, raw
Produce at low cost, and water-holding portion 30 can absorb the excess reagent that is added in the operation such as cleaning in the detection process, and carry out
Cleaning solution need to only be added dropwise on matrix 20 when the operation such as cleaning, eliminate repeatedly the complex operations of drawing liquid, operation is easier,
More save that time, detection efficiency are higher and pollution risk is small, testing result is more reliable.
In order to further excessive reagent is convenient for permeate from matrix 20 to water-holding portion 30, excess reagent is avoided to overflow to periphery
Out, matrix 20 is preferably also made of porous filter material.Such as matrix 20 is more made of the porous materials such as glass fibre
Hole filter membrane.Preferably, the lateral wall of the lateral wall Yu matrix 20 of water-holding portion 30 is substantially aligned or the lateral wall of water-holding portion 30
Stretch out in the lateral wall of matrix 20.Because reaction vessel is using porous membrane as solid phase matrix, coated protein matter thereon
Different types of antigen or antibody can be fixed by biotin, it is different so as to use same solid phase to detect
Antigen or antibody, versatility are good；Meanwhile biotinylated antigen/antibody is liquid phase in the preparation, substance (serum etc.) to be checked and life
Object element antigen/antibody carries out reacting between liquid phase and liquid phase, and reaction speed is very fast, wait after completion of the reaction again with solid phase binding
It is prepared into test object, enzyme marker is added and is incubated for, developing solution progress chromogenic reaction is added after cleaning solution is added dropwise, it is whole
Reaction speed is fast, high-efficient.
As shown in figure 3, the bottom of reaction vessel 10 is provided with aperture 111.Specifically, aperture is set in the bottom of ontology 11
111.Aperture 111 is preferably the underface for being set to water-holding portion 30.Under normal conditions, excessive examination can be absorbed in water-holding portion 30
Agent, but aperture 111 is set in 11 bottom of ontology, also it can enable aperture 111 row of the reagent from bottom when amount of reagent is excessive
Out.The quantity of aperture 111 and distribution can be configured according to specific emissions requirements, the number of present embodiment split shed 121
Amount is three, and arranges in isosceles triangle, it is highly preferred that arranging in isosceles triangle.
As shown in Figure 1, Figure 2 and Figure 4, enter in reaction vessel 10 for the ease of reagent, prevent outside splash, opening 121
Positioned at the top of reaction vessel 10, opening 121 is funnel-shaped.For the ease of with the detector that is detected to reaction result for example
Light meter, the detector of detector matched well generally also in a circular table shape, to improve detection accuracy, be open 121 inner wall
Profile and the profile of outside wall surface of detector of detector match.
In present embodiment, it is coated with anti-biotin antibodies on the base 20, is used for and biotinylated protein spy
The opposite sex combines, and the non-specific adsorption on matrix 20 is very low, ensure that high sensitivity, the high specific of detection.For the ease of
It is positioned in detection process, as shown in Fig. 1, Fig. 5 and Fig. 6, the outside of ontology 11 is provided with positioning region 40.The positioning region 40
Structure size is consistent with the structure snd size of fixed bit in detection environment, and positioning region 40 is annular in shape in present embodiment,
And preferably rectangular ring plate.
The application method of present embodiment immunodiagnosis detection device is as follows:
Reaction vessel 10 is soaked using buffer first, then by the mixed of the sample of pre-reaction and biotinylation reagent
It closes liquid (37 DEG C of reaction 6min) to be added on the matrix 20 of reaction vessel 10, after 37 DEG C of reaction 2min, enzyme marker is added, 37 DEG C anti-
2min is answered, after being added dropwise cleaning solution 2 times, light meter is tightly bonded with the opening 121 of reaction vessel 10, stops natural light interference
Afterwards, it carries out repeatedly surveying light, obtains photometric data.
Buffer, biotinylation reagent and enzyme marker etc. can be determined according to the substance specifically detected.For example, when to detect
When intraserous syphilis antibody, biotinylation Treponema pallidum antigen can be prepared, in specific detection first by serum and biotinylation syphilis
Antigen is mixed (the two is liquid phase) reaction, due to the two be the liquid phase reactor time it is very fast, then by the mixing after reaction
Solution is added in reaction vessel 10, in turn will will be combined with the anti-biotin antibodies on matrix 20 in reaction vessel 10
Reactive material is fixed.
The technical principle of the invention is described above in combination with a specific embodiment.These descriptions are intended merely to explain of the invention
Principle, and shall not be construed in any way as a limitation of the scope of protection of the invention.Based on the explanation herein, the technology of this field
Personnel can associate with other specific embodiments of the invention without creative labor, these modes are fallen within
Within protection scope of the present invention.
Claims (10)
1. a kind of immunodiagnosis detection device characterized by comprising
Matrix (20), is coated with protein matter thereon；And
Water-holding portion (30) is located at below described matrix (20), and the water-holding portion (30) is for absorbing from described matrix (20)
Permeate the liquid to go down.
2. immunodiagnosis detection device according to claim 1, which is characterized in that described matrix (20) is by porous filtering
Material is made.
3. immunodiagnosis detection device according to claim 1, which is characterized in that further include reaction vessel (10), institute
It states matrix (20) and the water-holding portion (30) to be set in the reaction vessel (10), the reaction vessel (10) has opening
(121), the opening (121) is located at the top of the reaction vessel (10) and is located at the surface of described matrix (20).
4. immunodiagnosis detection device according to claim 3, which is characterized in that the opening (121) is funnel-shaped.
5. immunodiagnosis detection device according to claim 4, which is characterized in that the inner wall of the opening (121)
Profile and the profile of outside wall surface of detector of detector match.
6. immunodiagnosis detection device according to claim 3, which is characterized in that the bottom of the reaction vessel (10)
It is provided with aperture (111).
7. according to the described in any item immunodiagnosis detection devices of claim 3 to 6, which is characterized in that the reaction vessel
It (10) include ontology (11) and the lid (12) being removable installed on the ontology (11), the opening (121) is set to
The top of the lid (12).
8. according to the described in any item immunodiagnosis detection devices of claim 3 to 6, which is characterized in that the reaction vessel
(10) outside of ontology (11) is provided with positioning region (40).
9. immunodiagnosis detection device according to claim 8, which is characterized in that the positioning region (40) is in straight-flanked ring
Shape.
10. immunodiagnosis detection device according to any one of claims 1 to 6, which is characterized in that described matrix (20)
On be coated with anti-biotin antibodies or streptavidin, be used for be added described matrix (20) on biotinylation egg
White matter specific binding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811140223.2A CN108982832A (en) | 2018-09-28 | 2018-09-28 | A kind of immunodiagnosis detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811140223.2A CN108982832A (en) | 2018-09-28 | 2018-09-28 | A kind of immunodiagnosis detection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108982832A true CN108982832A (en) | 2018-12-11 |
Family
ID=64544133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811140223.2A Pending CN108982832A (en) | 2018-09-28 | 2018-09-28 | A kind of immunodiagnosis detection device |
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| Country | Link |
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| CN (1) | CN108982832A (en) |
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