CN108968053A - A kind of muting sensitive formula powder of depth hydrolysis and preparation method thereof - Google Patents
A kind of muting sensitive formula powder of depth hydrolysis and preparation method thereof Download PDFInfo
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- CN108968053A CN108968053A CN201810894174.5A CN201810894174A CN108968053A CN 108968053 A CN108968053 A CN 108968053A CN 201810894174 A CN201810894174 A CN 201810894174A CN 108968053 A CN108968053 A CN 108968053A
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- 230000007062 hydrolysis Effects 0.000 title claims abstract description 101
- 238000006460 hydrolysis reaction Methods 0.000 title claims abstract description 101
- 239000000843 powder Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000005018 casein Substances 0.000 claims abstract description 36
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 36
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- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract description 18
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- 239000002994 raw material Substances 0.000 claims abstract description 13
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims abstract description 12
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- 229940088594 vitamin Drugs 0.000 claims abstract description 12
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- NXMUXTAGFPJGTQ-UHFFFAOYSA-N decanoic acid;octanoic acid Chemical compound CCCCCCCC(O)=O.CCCCCCCCCC(O)=O NXMUXTAGFPJGTQ-UHFFFAOYSA-N 0.000 claims abstract description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
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- 235000019742 Vitamins premix Nutrition 0.000 claims description 4
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- 239000002600 sunflower oil Substances 0.000 claims description 4
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 claims description 3
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- 239000001508 potassium citrate Substances 0.000 claims description 3
- 229960002635 potassium citrate Drugs 0.000 claims description 3
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical group [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 3
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- 239000008213 purified water Substances 0.000 claims description 3
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 claims description 3
- 239000001334 starch sodium octenyl succinate Substances 0.000 claims description 3
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- 125000005456 glyceride group Chemical group 0.000 claims description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
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- 210000002318 cardia Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
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- 102000004407 Lactalbumin Human genes 0.000 abstract description 4
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- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 2
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- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 206010059447 Allergic colitis Diseases 0.000 description 1
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- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
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- 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 description 1
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- 208000009793 Milk Hypersensitivity Diseases 0.000 description 1
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- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
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- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
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- 230000002052 anaphylactic effect Effects 0.000 description 1
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- 235000008452 baby food Nutrition 0.000 description 1
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- 230000003301 hydrolyzing effect Effects 0.000 description 1
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- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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- 239000003550 marker Substances 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pediatric Medicine (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention provides the muting sensitive formula powder and preparation method thereof of depth hydrolysis a kind of, it is made of the raw material for including following parts by weight: the PURE WHEY 3%-15% of depth hydrolysis, the casein 2%-10% of depth hydrolysis, glucose syrup 60%-75%, mixed vegetable oil 10%-25%, docosahexaenoic acid grease 0.1%-0.5%, arachidonic acid oil 0.1%-0.5%, Glycerin, mixed triester with caprylic acid capric acid 0.5%-5.0%, anhydrous butter oil 0.1%-0.5%, multi-vitamins 0.1%-0.6%, composite mineral matter 0.4%-2.2%.The advantage of the invention is that depth hydrolysis' lactalbumin and casein are small peptide and amino acid, almost without sensitization, and aminogram is balanced；Long-chain fat DHA and ARA, middle carbochain fat MCT, short-chain fat, butter oil and anhydrous butter oil are added, fatty acid profile is balanced, and the addition of short-chain fat enhances palatability.
Description
Technical field
The present invention relates to alimentation composition fields, more particularly to the muting sensitive formula powder and preparation method thereof of depth hydrolysis.
Background technique
Infant food allergy is a kind of more typical phenomenon, the food species of human allergy can be caused also to compare more.
Common meal anaphylactogen mainly has milk, egg and peanut etc..Wherein milk protein (cow ' s milk protein, CMP)
It is the most common anaphylactic food allergen of infant again.Milk protein allergy (cow ' s milk protein
Allergy, CMPA) refer to the immunological response that one or more of milk proteinoid occur for human body.In baby and low age youngster
Tong Zhong, CMPA are a kind of most commonly seen diet diversities.Available data shows that there is doubtful by 5%~15% children
The symptom of CMPA.The clinical manifestation of CMPA can be involved multiple organ, multi viscera, mainly there is skin, respiratory system, alimentary canal etc..
Light-moderate and severe can be classified as according to severity.Infant cutaneous manifestations are mainly atopic dermatitis (atopic
Dermatitis, AD), such as eczema, itch, fash, nettle rash, oedema, drying, severe infant are exudative or severe AD；
Respiratory symptom is usually asthma, cough, allergic rhinitis, and it is tired with breathing to occur the acute edema of the larynx or bronchial obstruction when serious
It is difficult；Die Gastrointestinale Manifestation is usually frequent reflux, vomiting, diarrhea, constipation, if it is poor iron-deficient caused by bloody stool under occult blood or mirror occur
It is diagnosable to be showed for severe when blood, severe refractory ulcerative colitis.Some infants even there is also immediate allergic syndrome, this
Shi Bixu goes to hospital to rescue in time, therefore early diagnoses and be of great significance with therapeutic intervention.
Hydrolyzed formulas milk powder is that sensibiligen macro-molecular protein is hydrolyzed into small-molecular peptides and amino acid, can be effectively relieved
Quick symptom.It at present about muting sensitive formula powder mostly based on hydrolyzing lactoalbumin, and is added by dry method.The formula of protein hydrolysate
The general mouthfeel of powder is more bitter, poor taste, it is not easy to be received.
Summary of the invention
In view of the defect of prior art described above, the purpose of the present invention is to provide the muting sensitive formulas of depth hydrolysis a kind of
Powder, with the preparation of dry and wet hybrid technique, wherein lactalbumin and casein are hydrolyzed to small peptide and amino after hydrolysis process three times
Acid, it is almost nonantigenic.
Specifically, the present invention provides the muting sensitive formula powder of depth hydrolysis a kind of, and the formula powder is by including following parts by weight
Raw material be made: the PURE WHEY 3%-15% of depth hydrolysis, the casein 2%-10% of depth hydrolysis, glucose syrup 60%-75%,
Mixed vegetable oil 10%-25%, docosahexaenoic acid grease 0.1%-0.5%, arachidonic acid oil 0.1%-0.5%, pungent capric acid
Glyceride 0.5%-5.0%, anhydrous butter oil 0.1%-0.5%, multi-vitamins 0.1%-0.6%, composite mineral matter 0.4%-2.2%, institute
State the mass percent that percentage is total mass of raw material；
The ratio of the casein of the PURE WHEY and partial hydrolysis of the partial hydrolysis is about 50:50 to 70:30, and wherein newborn
The small peptide molecular weight that the partial hydrolysate of albumin powder and casein has is between 200-600；
The mixed vegetable oil includes following components in parts by weight: soybean oil 1%-15%, palm oil 5%-20%, sunflower oil 4%-
15%, linseed oil 0.5%-5.0%, the percentage are the mass percent of total mass of raw material；
The composite mineral matter is infant's mineral substance premix, and content meets the requirement of national standard sign value；
The multi-vitamins are infant's vitamin premix, and content meets the requirement of national standard sign value.
Preferably, the ratio of the casein of the PURE WHEY and depth hydrolysis of the depth hydrolysis is about 60:40.
Preferably, the hydrolysis degree of the casein of the PURE WHEY and depth hydrolysis of the depth hydrolysis is 32%-35%.
Preferably, the hydrolysis degree 33% of the casein of the PURE WHEY and depth hydrolysis of the depth hydrolysis.
Preferably, the PURE WHEY of the depth hydrolysis and the casein of depth hydrolysis account for protein gross mass at least
95%, at least 95%, free aminoacid content is lower than 3%, and the high molecular weight protein ratio of 5000Da or more is less than 1%.
In addition, the present invention also provides a kind of preparation method of the muting sensitive formula powder of depth hydrolysis described in claim 1,
Characterized by the following steps:
(1) water phase prepare: concentrated whey protein powder, casein are dissolved in 36 DEG C -50 DEG C of purified water, be added protease into
Row hydrolyzes three times, and pepsin, pH value 2-6.5 is added in hydrolysis for the first time, and hydrolysis temperature is 35-55 DEG C, hydrolysis time 25-
60min；Hot inactivated pepsin, inactivation temperature are 80 DEG C~98 DEG C, time 5min~15min, after being cooled to room temperature, second
Alkali protease is added in hydrolysis, and pH value is 6.0-9.0, and hydrolysis temperature is 35-55 DEG C, hydrolysis time 25-60min；Heat inactivation alkali
Property protease, inactivation temperature is 80 DEG C~98 DEG C, time 5min~15min, and after being cooled to room temperature, third time hydrolysis is added neutral
Protease, pH value 6.0-8.0, hydrolysis temperature are 35-55 DEG C, hydrolysis time 25-60min；Heat inactivation neutral proteinase, inactivation
Temperature is 80 DEG C~98 DEG C, time 5min~15min, after being cooled to room temperature, and glucose syrup, the mixing of stabilizer high speed shear is added
Uniformly, feed liquid A is obtained；
(2) oil is mutually prepared: by vegetable oil and pungent, glycerol decanoate, docosahexaenoic acid grease, arachidonic acid oil, nothing
After mixing, emulsifier 10-30min is added in water cream, and emulsifying temperature is 60-75 DEG C, obtains feed liquid B；
(3) two-phase mixtures: feed liquid A being mixed with feed liquid B, material C is obtained after shear-mixed, sterilization, spray drying, described
Spray drying also includes fluidized bed drying, and fluidized bed drying temperature is 30 DEG C -40 DEG C；
(4) dry mixing process: multi-vitamins are uniformly mixed with material C to get product；
Preferably, in the step (1): pepsin, alkali protease, neutral proteinase additive amount be every 100mL junket
It is 12000~15000U that enzyme-activity unit is added in protein solution；The stabilizer is selected from potassium citrate 1.0%-2.5%.
Preferably, in the step (2): the emulsifier and its dosage are selected from starch Sodium Octenyl Succinate 0.1%-
1.5%, citric acid fatty glyceride 0.0%-1.5%, single diglycerol acid aliphatic ester 0.0%-1.5%.
Preferably, in step (3): sterilization conditions are 68 DEG C -70 DEG C of temperature, time 20-40min.
Preferably, spray drying condition are as follows: 160 DEG C -190 DEG C of inlet air temperature, 80 DEG C -95 DEG C of temperature of outgoing air.
As described above, the muting sensitive formula powder of depth hydrolysis of the invention, has the advantages that depth water in this formula
It solves lactalbumin and casein is small peptide and amino acid, almost without sensitization, and aminogram is balanced；Other than mixed vegetable oil
Long-chain fat DHA and ARA, middle carbochain fat MCT and short-chain fat butter oil anhydrous butter oil are also added, fatty acid profile is balanced,
And the addition of short-chain fat enhances palatability.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily.
Embodiment 1
A kind of muting sensitive formula powder of depth hydrolysis is made: the PURE WHEY of depth hydrolysis of the raw material for including following parts by weight
3%, the casein 2% of depth hydrolysis, glucose syrup 60%, mixed vegetable oil 10%, docosahexaenoic acid grease 0.1%, peanut
Tetraene acid lipid 0.1%, Glycerin, mixed triester with caprylic acid capric acid 0.5%, anhydrous butter oil 0.1%, multi-vitamins 0.1%, composite mineral matter 0.4%, institute
State the mass percent that percentage is total mass of raw material；The casein of the PURE WHEY and partial hydrolysis of the partial hydrolysis
Ratio is about 50:50, and the small peptide molecular weight that wherein partial hydrolysate of PURE WHEY and casein has is in 200-600
Between；The mixed vegetable oil includes following components in parts by weight: soybean oil 1%, palm oil 5%, sunflower oil 4%, linseed oil
0.5%, the percentage is the mass percent of total mass of raw material；The composite mineral matter is infant's mineral substance premix,
Content meets the requirement of national standard sign value；The multi-vitamins are infant's vitamin premix, and content meets national standard mark
Value requires.The hydrolysis degree of the casein of the PURE WHEY and depth hydrolysis of the depth hydrolysis is 32%.The depth hydrolysis
PURE WHEY and depth hydrolysis casein hydrolysis degree 33%.The PURE WHEY and depth water of the depth hydrolysis
The casein of solution accounts at least the 95% of protein gross mass, and free aminoacid content is lower than 3%, and big point of 5000Da or more
Sub- protein ratio is less than 1%.
Embodiment 2
A kind of muting sensitive formula powder of depth hydrolysis is made: the PURE WHEY of depth hydrolysis of the raw material for including following parts by weight
15%, the casein 10% of depth hydrolysis, glucose syrup 75%, mixed vegetable oil 25%, docosahexaenoic acid grease 0.5%, flower
Raw tetraene acid lipid 0.5%, Glycerin, mixed triester with caprylic acid capric acid 5.0%, anhydrous butter oil 0.5%, multi-vitamins 0.6%, composite mineral matter 2.2%,
The percentage is the mass percent of total mass of raw material；The PURE WHEY of the partial hydrolysis and the casein of partial hydrolysis
Ratio be about 70:30, and the small peptide molecular weight that wherein partial hydrolysate of PURE WHEY and casein has is in 200-
Between 600；The mixed vegetable oil includes following components in parts by weight: soybean oil 15%, palm oil 20%, sunflower oil 15%, Asia
Flaxseed oil 5.0%, the percentage are the mass percent of total mass of raw material；The composite mineral matter is that infant's minerals are pre-
Mixing, content meet the requirement of national standard sign value；The multi-vitamins are infant's vitamin premix, and content meets state
Mark sign value requirement.The hydrolysis degree of the casein of the PURE WHEY and depth hydrolysis of the depth hydrolysis is 35%.The depth
Spend the hydrolysis degree 33% of the PURE WHEY of hydrolysis and the casein of depth hydrolysis.The PURE WHEY of the depth hydrolysis and
The casein of depth hydrolysis accounts at least the 95% of protein gross mass, and free aminoacid content is lower than 3%, and 5000Da or more
High molecular weight protein ratio less than 1%.
Embodiment 3
A kind of preparation method of the muting sensitive formula powder of depth hydrolysis described in embodiment 1, comprising the following steps: (1) prepared by water phase:
Concentrated whey protein powder, casein are dissolved in 36 DEG C -50 DEG C of purified water, protease is added and is hydrolyzed three times, first
Pepsin, pH value 2-6.5 is added in secondary hydrolysis, and hydrolysis temperature is 35-55 DEG C, hydrolysis time 25-60min；Heat inactivation stomach egg
White enzyme, inactivation temperature are 80 DEG C~98 DEG C, time 5min~15min, after being cooled to room temperature, and basic protein is added in second of hydrolysis
Enzyme, pH value are 6.0-9.0, and hydrolysis temperature is 35-55 DEG C, hydrolysis time 25-60min；Heat inactivation alkali protease, inactivation temperature
Degree is 80 DEG C~98 DEG C, time 5min~15min, after being cooled to room temperature, and neutral proteinase is added in third time hydrolysis, and pH value is
6.0-8.0, hydrolysis temperature are 35-55 DEG C, hydrolysis time 25-60min；Heat inactivation neutral proteinase, inactivation temperature be 80 DEG C~
98 DEG C, time 5min~15min, after being cooled to room temperature, addition glucose syrup, stabilizer high speed shear are uniformly mixed, and are expected
Liquid A；(2) oil is mutually prepared: by vegetable oil and pungent, glycerol decanoate, docosahexaenoic acid grease, arachidonic acid oil, nothing
After mixing, emulsifier 10-30min is added in water cream, and emulsifying temperature is 60-75 DEG C, obtains feed liquid B；(3) two-phase is mixed
It closes: feed liquid A being mixed with feed liquid B 1:1 in mass ratio, material C, the spray are obtained after shear-mixed, sterilization, spray drying
Dry mist also includes fluidized bed drying, and fluidized bed drying temperature is 30 DEG C -40 DEG C；(4) dry mixing process: by multi-vitamins with
Material C is uniformly mixed to get product；In the step (1): pepsin, alkali protease, neutral proteinase additive amount be
It is 12000~15000U that enzyme-activity unit is added in every 100mL casein solution；The stabilizer is selected from potassium citrate 1.0%-
2.5%.In the step (2): the emulsifier and its dosage are selected from starch Sodium Octenyl Succinate 0.1%-1.5%, citric acid rouge
Fatty acid glyceride 0.0%-1.5%, single diglycerol acid aliphatic ester 0.0%-1.5%.In step (3): sterilization conditions are 68 DEG C of temperature-
70 DEG C, time 20-40min.Spray drying condition are as follows: 160 DEG C -190 DEG C of inlet air temperature, 80 DEG C -95 DEG C of temperature of outgoing air.
Baby under the high risk of allergy before birth or when birth be randomly assigned with when they with any reason from mother
Using the experimental formula powder and control formula powder of the embodiment of the present invention 1 or 2 when cream wean, control formula is Enfamil Lipil
® (Mead Johnson Nutrition).Age of the follow-up participant up to 2 years old.Main final result index (outcome) is
Life First Year bottom measure intestinal inflammatory (excrement calprotectin (calprotecitin)) and to main allergen it is sensitive
Marker (as measured by the specific IgE as serum total Ig E and for cow's milk, egg, soybean and dermatophagoides pteronyssinus).
Secondary final result index includes the presence in the entire first 2 years following allergic manifestations of life: for example atopic dermatitis (passes through
Measured via the diagnosis of SCORAD and the assessment of seriousness), the stomach and intestine performance of food hypersenstivity (for example, allergic colitis,
Enteritis anaphylactica, anaphylaxis esophagitis, allergy gastroesophagitis and/or allergic urticaria) and infectious diseases disease incidence.
Fecal excretion type IgA and some comforts/tolerance standard will be monitored (for example, times of defecation and consistency, gas, agitation
Irritability and formula acceptance).The inclusion criteria of research, which is included in parent both sides or one side of parent and siblings, has allergy
The health full term baby of history.The alimentation composition of embodiment 1-2 reduces the breaking-out of allergy compared to control.
In conclusion depth hydrolysis' lactalbumin and depth hydrolysis' casein that the present invention obtains essentially eliminate its sensitization
Activity easily absorbs and is rich in a variety of active ingredients, is suitable for baby formula milk powder, and can be used as ordinary food ingredient and be applied to food
Product industry.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. the muting sensitive formula powder of depth hydrolysis a kind of, it is characterised in that the formula powder is by the raw material system including following parts by weight
At: the PURE WHEY 3%-15% of depth hydrolysis, the casein 2%-10% of depth hydrolysis, glucose syrup 60%-75%, mixed plant
Oily 10%-25%, docosahexaenoic acid grease 0.1%-0.5%, arachidonic acid oil 0.1%-0.5%, Glycerin, mixed triester with caprylic acid capric acid
0.5%-5.0%, anhydrous butter oil 0.1%-0.5%, multi-vitamins 0.1%-0.6%, composite mineral matter 0.4%-2.2%, the percentage
Than the mass percent for total mass of raw material；
The ratio of the casein of the PURE WHEY and partial hydrolysis of the partial hydrolysis is about 50:50 to 80:20, and wherein newborn
The small peptide molecular weight that the partial hydrolysate of albumin powder and casein has is between 200-600；
The mixed vegetable oil includes following components in parts by weight: soybean oil 1%-15%, palm oil 5%-20%, sunflower oil 4%-
15%, linseed oil 0.5%-5.0%, the percentage are the mass percent of total mass of raw material；
The composite mineral matter is infant's mineral substance premix, and content meets the requirement of national standard sign value；
The multi-vitamins are infant's vitamin premix, and content meets the requirement of national standard sign value.
2. the muting sensitive formula powder of depth hydrolysis according to claim 1, it is characterised in that the whey egg of the depth hydrolysis
The ratio of white powder and the casein of depth hydrolysis is about 60:40.
3. the muting sensitive formula powder of depth hydrolysis according to claim 1, it is characterised in that the whey egg of the depth hydrolysis
The hydrolysis degree of white powder and the casein of depth hydrolysis is 30%-35%.
4. the muting sensitive formula powder of depth hydrolysis according to claim 1, it is characterised in that the whey egg of the depth hydrolysis
The hydrolysis degree 31%-33% of white powder and the casein of depth hydrolysis.
5. the muting sensitive formula powder of depth hydrolysis according to claim 1, it is characterised in that the whey egg of the depth hydrolysis
White powder and the casein of depth hydrolysis account at least the 95% of protein gross mass, and free aminoacid content is lower than 3%, and 5000Da
Above high molecular weight protein ratio is less than 1%.
6. a kind of preparation method of the muting sensitive formula powder of depth hydrolysis described in claim 1, it is characterised in that including following step
It is rapid:
(1) water phase prepare: concentrated whey protein powder, casein are dissolved in 36 DEG C -50 DEG C of purified water, be added protease into
Row hydrolyzes three times, and pepsin, pH value 2-6.5 is added in hydrolysis for the first time, and hydrolysis temperature is 35-55 DEG C, hydrolysis time 25-
60min；Hot inactivated pepsin, inactivation temperature are 80 DEG C~98 DEG C, time 5min~15min, after being cooled to room temperature, second
Alkali protease is added in hydrolysis, and pH value is 6.0-9.0, and hydrolysis temperature is 35-55 DEG C, hydrolysis time 25-60min；Heat inactivation alkali
Property protease, inactivation temperature is 80 DEG C~98 DEG C, time 5min~15min, and after being cooled to room temperature, third time hydrolysis is added neutral
Protease, pH value 6.0-8.0, hydrolysis temperature are 35-55 DEG C, hydrolysis time 25-60min；Heat inactivation neutral proteinase, inactivation
Temperature is 80 DEG C~98 DEG C, time 5min~15min, after being cooled to room temperature, and glucose syrup, the mixing of stabilizer high speed shear is added
Uniformly, feed liquid A is obtained；
(2) oil is mutually prepared: by vegetable oil and pungent, glycerol decanoate, docosahexaenoic acid grease, arachidonic acid oil, nothing
After mixing, emulsifier 10-30min is added in water cream, and emulsifying temperature is 60-75 DEG C, obtains feed liquid B；
(3) two-phase mixtures: feed liquid A being mixed with feed liquid B, material C is obtained after shear-mixed, sterilization, spray drying, described
Spray drying also includes fluidized bed drying, and fluidized bed drying temperature is 30 DEG C -40 DEG C；
(4) dry mixing process: multi-vitamins are uniformly mixed with material C to get product.
7. the preparation method of muting sensitive formula powder according to claim 6, it is characterised in that in the step (1): stomach cardia
Enzyme, alkali protease, neutral proteinase additive amount be added in every 100mL casein solution enzyme-activity unit be 12000~
15000U；The stabilizer is selected from potassium citrate 1.0%-2.5%.
8. the preparation method of muting sensitive formula powder according to claim 6, it is characterised in that in the step (2): the cream
Agent and its dosage are selected from starch Sodium Octenyl Succinate 0.1%-1.5%, citric acid fatty glyceride 0.0%-1.5%, Dan Shuan
Glyceric acid aliphatic ester 0.0%-1.5%.
9. the preparation method of muting sensitive formula powder according to claim 6, it is characterised in that in step (3): sterilization conditions are
68 DEG C -70 DEG C of temperature, time 20-40min.
10. the preparation method of muting sensitive formula powder according to claim 6, it is characterised in that in step (3): spray drying item
Part are as follows: 160 DEG C -190 DEG C of inlet air temperature, 80 DEG C -95 DEG C of temperature of outgoing air.
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