CN108958190B - Analgin production process control system based on computer control - Google Patents
Analgin production process control system based on computer control Download PDFInfo
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- CN108958190B CN108958190B CN201810751741.1A CN201810751741A CN108958190B CN 108958190 B CN108958190 B CN 108958190B CN 201810751741 A CN201810751741 A CN 201810751741A CN 108958190 B CN108958190 B CN 108958190B
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 13
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 claims abstract description 76
- 238000005917 acylation reaction Methods 0.000 claims abstract description 51
- 230000010933 acylation Effects 0.000 claims abstract description 50
- 230000007062 hydrolysis Effects 0.000 claims abstract description 40
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 40
- 238000007034 nitrosation reaction Methods 0.000 claims abstract description 29
- 230000011987 methylation Effects 0.000 claims abstract description 17
- 238000007069 methylation reaction Methods 0.000 claims abstract description 17
- 230000009935 nitrosation Effects 0.000 claims abstract description 14
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 6
- 239000000835 fiber Substances 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 42
- 230000001105 regulatory effect Effects 0.000 claims description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- 238000004821 distillation Methods 0.000 claims description 30
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 claims description 30
- 239000011229 interlayer Substances 0.000 claims description 22
- 238000006243 chemical reaction Methods 0.000 claims description 20
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 20
- 230000009467 reduction Effects 0.000 claims description 17
- 238000007599 discharging Methods 0.000 claims description 12
- 235000010288 sodium nitrite Nutrition 0.000 claims description 10
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 10
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 238000011084 recovery Methods 0.000 claims description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 4
- 238000012790 confirmation Methods 0.000 claims description 4
- 230000001276 controlling effect Effects 0.000 claims description 4
- 235000019253 formic acid Nutrition 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 2
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 32
- WSJBSKRPKADYRQ-UHFFFAOYSA-N 4-formylaminoantipyrine Chemical compound CN1C(C)=C(NC=O)C(=O)N1C1=CC=CC=C1 WSJBSKRPKADYRQ-UHFFFAOYSA-N 0.000 description 17
- UNZIDPIPYUMVPA-UHFFFAOYSA-M Sulpyrine Chemical compound O.[Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 UNZIDPIPYUMVPA-UHFFFAOYSA-M 0.000 description 17
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 description 8
- 229960005222 phenazone Drugs 0.000 description 8
- 238000003860 storage Methods 0.000 description 7
- 239000003921 oil Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 239000013307 optical fiber Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 239000000498 cooling water Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- JILCEWWZTBBOFS-UHFFFAOYSA-N 4-(methylamino)antipyrine Chemical compound O=C1C(NC)=C(C)N(C)N1C1=CC=CC=C1 JILCEWWZTBBOFS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- AKXKFZDCRYJKTF-UHFFFAOYSA-N 3-Hydroxypropionaldehyde Chemical compound OCCC=O AKXKFZDCRYJKTF-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/41865—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by job scheduling, process planning, material flow
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/32—Operator till task planning
- G05B2219/32252—Scheduling production, machining, job shop
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Quality & Reliability (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention provides a control system for an analgin production process based on computer control, which is characterized by comprising the following components: 01PLC control cabinet, 02PLC control cabinet, AT methylation hydrolysis substation, FAA methylation substation, MAA neutralization substation, condensation-finished product substation, AA nitrosation control substation, FAA acylation control substation, MAA hydrolysis control substation, analgin station, fiber switch and field instrument; the invention can lead the traditional technical process to be intensified and visualized, and greatly improves the production efficiency and the management level while reducing the labor intensity and the management cost of workers.
Description
Technical Field
The invention relates to the field of pharmaceutical chemical industry and industrial computer control, in particular to a computer-controlled analgin production system.
Background
Analgin, also known as reuterin, 1-phenyl-2, 3-dimethyl-4-methylamino-5-pyrazolone-N-methylsulphonic acid monohydrate. Relative molecular mass 351.36. White to pale yellow crystals or crystalline powder. Is insoluble in diethyl ether, soluble in ethanol, and soluble in water, and the aqueous solution is easy to turn yellow.
AT present, pyrazolone is taken as an initial raw material in the industrial production route of analgin, methylation, hydrolysis and alkalization are carried out to obtain Antipyrine (AT) oil, nitrosation, reduction and hydrolysis neutralization are carried out to the AT oil to obtain 4-aminoantipyrine (AA) oil, acylation, crystallization and centrifugation are carried out to the AA oil to obtain 4-Formamidoantipyrine (FAA), methylation, hydrolysis and neutralization are carried out to the FAA to obtain 4-methylaminoantipyrine oil (MAA), and finally condensation, cooling, crystallization and centrifugal drying are carried out to the MAA oil, formaldehyde and sodium pyrosulfite to obtain an analgin finished product.
The production process of analgin is mature, however, in the conventional manual operation process, some procedures need to be finely controlled due to reaction characteristics, or frequent operation of workers is needed due to the complex process, so that the labor intensity of the workers is greatly increased. With the development of industrial control, more and more fine control schemes can be applied to the traditional analgin production, so that the traditional technological process can be intensified and visualized, the labor intensity of workers and the management cost are reduced, and the production efficiency and the management level are greatly improved.
The Programmable Logic Controller (PLC) is a digital operation electronic system which mainly takes a microprocessor as a control core and is specially designed for application in an industrial environment on the basis of absorbing the characteristics of a computer, an automatic control technology and a communication technology. It uses a programmable memory, in which the instructions for implementing logical operation, sequence control, timing, counting and arithmetic operation are stored, and utilizes digital or analog input and output to control various mechanical equipments or production processes. The CPU in the PLC is a main component of data calculation and processing, and performs all functions of control, data processing, and the like of a system program. The memory is a storage device in the PLC, and can store programs, user data, and the like. The I/O module is an important transmission channel between the PLC and an external sensor (e.g., temperature transmitter, level transmitter, pressure transmitter) and a control device (e.g., pneumatic solenoid valve, regulating valve), and can be mainly divided into I/O signals of digital quantity, analog quantity, etc. according to the difference of signals to be controlled.
Disclosure of Invention
The invention provides a control system for an analgin production process based on computer control, which is characterized by comprising the following components: 01PLC control cabinet, 02PLC control cabinet, AT methylation hydrolysis substation, FAA methylation substation, MAA neutralization substation, condensation-finished product substation, AA nitrosation control substation, FAA acylation control substation, MAA hydrolysis control substation, analgin station, fiber switch and field instrument.
The AT methylation hydrolysis substation, the FAA methylation substation, the MAA neutralization substation and the condensation-finished product substation are used for collecting and intensively displaying field temperature data and belong to a remote display system; the AA nitrosation control substation, the FAA acylation control substation and the MAA hydrolysis control substation can realize production control besides collecting and displaying field instrument data, and belong to a remote control system.
The field instrument mainly comprises a temperature transmitter, a pressure transmitter, a digital flowmeter, a pneumatic solenoid valve and a pneumatic regulating valve; the field instrument is accessed into the 01PLC control cabinet and the 02PLC control cabinet through cables, and SIMENS S S7-400 type CPUs in the 01PLC control cabinet and the 02PLC control cabinet transmit corresponding data to each substation through 6XV1830-3EH10Profibus flexible cables according to the configuration programming of users so as to be used for observation and judgment of operators; and the 01PLC control cabinet and the 02PLC control cabinet are connected into the optical fiber switch through optical fibers, and then the analgin master station establishes communication with the optical fiber switch through the optical fibers, so that the data of each PLC control cabinet is read to realize the analgin production process control system.
In the remote display system, the tank body temperature is connected with the 01PLC control cabinet and the 02PLC control cabinet through cables, so that the CPUs in the 01PLC control cabinet and the 02PLC control cabinet can acquire data on the tank temperature transmitter in real time, and the data are converted into an integral view through compiling software.
In the remote control system, a pneumatic control valve and a flowmeter are arranged on the feeding pipeline, pneumatic control valves are arranged on the reaction kettle and the reduction tank interlayer cooling water inlet pipeline, and a temperature transmitter is arranged in the tank.
Wherein:
(1) in each remote display system, the tank body temperature is connected with the PLC control cabinet through a cable, so that a CPU in the PLC control cabinet can acquire data on the tank temperature transmitter in real time and convert the data into an overall view through compiling software, and operation workers can conveniently grasp the information of an operation site integrally.
(2) In the AA remote control system, a pneumatic regulating valve and a flowmeter are arranged on a feed pipeline, pneumatic regulating valves are arranged on a nitrosation reaction kettle and a reduction tank interlayer cooling water inlet pipeline, and a temperature transmitter is arranged in the tank. All field instruments establish contact with a PLC control cabinet through cables, an operator sets a flow value on a substation according to the condition of a reaction end point, and then the PLC sends an instruction to a field feeding regulating valve and a flowmeter to realize accurate control of the flow; and the pneumatic regulating valves of the cooling water inlet pipelines of the intermediate layers of the nitrosation reaction kettle and the reduction tank automatically regulate the opening degree according to the temperature in each tank, so that the automatic temperature control is realized.
(3) In the FAA remote control system, a pneumatic regulating valve is arranged on a steam inlet pipeline of an acylation tank interlayer, a pneumatic electromagnetic valve is arranged on a process low-temperature water inlet pipeline and a process low-temperature water outlet pipeline, a pneumatic electromagnetic valve is arranged on a process low-temperature water inlet pipeline, a temperature transmitter is arranged in the acylation tank, a pressure transmitter is arranged on the tank interlayer, a pneumatic electromagnetic valve is arranged on an acylation tank exhaust pipeline, a process air pressure pipeline and a process vacuum pipeline are arranged on a pipeline which is the same as the tank exhaust pipeline, pneumatic electromagnetic valves are arranged on the process air pressure pipeline and the process vacuum pipeline, a pneumatic electromagnetic valve is arranged on an exhaust cooler process low-temperature. According to the control system, after the system is manually started according to a process flow, the PLC sends an instruction to control the temperature in the tank through the temperature in the acylation tank, the opening degree of a steam regulating valve and the interlayer pressure by the CPU in the PLC according to preset program parameters, the temperature rise and the heat preservation reaction are carried out in the control process, then the vacuum pump and a pneumatic electromagnetic valve on a corresponding pipeline are controlled by the internal program of the PLC, the reduced pressure distillation is realized, and finally the material is discharged and the control is finished.
(4) In the MAA remote control system, a sulfuric acid pipeline, a methanol pipeline, a methylation liquid pipeline and an exhaust pipeline of an MAA hydrolysis tank are provided with pneumatic electromagnetic valves, a temperature transmitter is arranged in the MAA hydrolysis tank, a steam inlet pipeline of a tank interlayer is provided with a pneumatic adjusting valve, a tank interlayer is provided with a pressure transmitter, the top of a fractionating tower is provided with the temperature transmitter and the pressure transmitter, a cooler process low-temperature water pipeline is provided with the pneumatic electromagnetic valves, a reflux pipeline of a distillation tower is provided with a rotor flow meter, a discharge pipeline of the distillation tower is provided with the pneumatic adjusting valve, and a dilute methanol outlet pipeline and a methyl formate outlet pipeline. In the system, according to the process flow, after the system is manually started, a PLC sends instructions to control pneumatic solenoid valves on a sulfuric acid pipeline, a methanol pipeline, a methylation liquid pipeline and an exhaust pipeline respectively through preset program parameters, then the PLC controls an interlayer steam pipeline regulating valve, interlayer pressure parameters and the temperature in a hydrolysis tank to realize temperature control according to the program, when the set process temperature is reached, the PLC controls a condenser process low-temperature water pneumatic solenoid valve, a discharge pipeline regulating valve and a pneumatic solenoid valve to discharge materials, and the CPU automatically controls the opening of a discharge regulating valve according to the temperature of the top of a distillation tower in the discharge process so as to ensure fractionation components until the reaction is finished.
Drawings
FIG. 1 is a schematic diagram of a computerized analgin control system. Wherein 1, a pressure transmitter; 2. a temperature transmitter; 3. a flow meter; 4. a pneumatic regulating valve; 5. a pneumatic solenoid valve; 6. 01PLC control cabinet; 7. 02 a PLC control cabinet; 8. AT methylation hydrolysis substation; 9. FAA acylation control substation; 10. a FAA methylation substation; 11. AA nitrosation control substation; 12. a fiber optic switch; 13. MAA neutralizing substations; 14. condensation-finished product substation; 15. MAA hydrolysis control substation; 16. analgin station; 17. a cable; 18. 6XV1830-3EH10Profibus flexible cable; 19. an optical fiber;
FIG. 2 is a schematic diagram of a remote display system in the analgin computer control system. 20, a reaction kettle; 2. a temperature transmitter; 17. a cable; 18. 6XV1830-3EH10Profibus flexible cable;
FIG. 3 is a schematic diagram of AA nitrosation control system in analgin computer control system. 21, a sodium nitrite solution storage tank; 22. an AT-SO4 solution storage tank; 23. sodium nitrite pipeline flowmeter; 24. a sodium nitrite pipeline pneumatic regulating valve; 25. an AT-SO4 pipeline flow meter; 26. an AT-SO4 pipeline pneumatic regulating valve; 27. a pneumatic regulating valve of a low-temperature water pipeline of the nitrosation reaction kettle process; 28. a nitrosation reaction kettle; 29. the temperature in the nitrosation reaction kettle tank; 30. a pneumatic regulating valve of a low-temperature water pipeline of the reduction tank process; 31. a reduction tank; 32. the temperature in the reduction tank; 6. 01PLC control cabinet; 11. AA nitrosation control substation; 17. a common cable; 18. 6XV1830-3EH10Profibus flexible cable;
FIG. 4 is a schematic diagram of the FAA acylation control system in the analgin computer control system. 33, taking the acylation tank out of the pneumatic electromagnetic valve of the process low-temperature water pipeline; 34. entering a process low-temperature water pipeline pneumatic electromagnetic valve; 35. a steam inlet pipeline pneumatic regulating valve; 36. an acylation tank; 37. an acylation tank temperature transmitter; 38. an exhaust pipeline pneumatic solenoid valve; 39. an acylation tank interlayer process compressed air pipeline pneumatic electromagnetic valve; 40. a pneumatic electromagnetic valve of a process vacuum pipeline; 41. an acylation tank interlayer pressure transmitter; 42. a steam exhaust water pipeline pneumatic electromagnetic valve; 43. a pneumatic electromagnetic valve of a process low-temperature water recovery pipeline; 44. a pneumatic electromagnetic valve of a process compressed air pipeline; 45. an exhaust gas cooler; 46. a cooler process low-temperature water-pneumatic electromagnetic valve; 47. a vacuum pump; 6. 01PLC control cabinet; 9. FAA acylation control substation; 17. a common cable; 18. 6XV1830-3EH10Profibus flexible cable;
FIG. 5 is a schematic diagram of the MAA hydrolysis control system in the analgin computer control system. 7, 02PLC control cabinet; 15. MAA hydrolysis control substation; 17. a common cable; 18. 6XV1830-3EH10Profibus flexible cable; 48. a hydrolysate feeding pipeline; 49. a concentrated sulfuric acid storage tank; 50. a concentrated methanol storage tank; 51. a pneumatic electromagnetic valve of a concentrated methanol discharging pipeline; 52. a concentrated sulfuric acid pipeline pneumatic electromagnetic valve; 53. a methylation liquid feeding pipeline pneumatic electromagnetic valve; 54. MAA hydrolysis tank temperature transmitter; 55. MAA hydrolysis tank interlayer pressure transmitter; 56. an MAA hydrolysis tank exhaust steam pipeline; 57. an MAA hydrolysis tank; 58. an MAA hydrolysis tank interlayer steam pipeline pneumatic regulating valve; 59. a methyl formate storage tank; 60. a dilute methanol storage tank; 61. a distillation tower top temperature transmitter; 62. a distillation tower top pressure transmitter; 63. a condenser process low-temperature water pipeline pneumatic electromagnetic valve; 64. a distillation column return line flow meter; 65. a distillation tower discharge pipeline flowmeter; 66. the pneumatic regulating valve of the discharging pipeline; 67. a methyl formate outlet pipeline pneumatic electromagnetic valve; 68. a dilute methanol outlet pipeline pneumatic electromagnetic valve; 69. a reflux condenser; 70. MAA hydrolysis tank exhaust line pneumatic solenoid valve.
The specific implementation mode is as follows:
the invention will be further explained with reference to the accompanying figures 2-5,
in the remote display system in fig. 2, a temperature transmitter 2 in a tank body is connected to a PLC control cabinet 01 through a common cable; 02PLC control cabinet 7, according to the configuration programming of the user, SIMENS S7-400 type CPU in the PLC control cabinet transmits the corresponding data to AT methylated hydrolysis substation 8, FAA methylated substation 10, MAA neutralized substation 13 and condensation-finished product substation 14 through 186 XV1830-3EH10Profibus flexible cable 18, and the operation staff can remotely realize the real-time master of the main parameters of the operation site.
In the AA remote control system shown in FIG. 3, a sodium nitrite pipeline flow meter 23, a sodium nitrite pipeline pneumatic regulating valve 24, an AT-SO4 pipeline flow meter 25, an AT-SO4 pipeline pneumatic regulating valve 26, a nitrosation reactor process low-temperature water pipeline pneumatic regulating valve 27, a nitrosation reactor tank temperature 29, a reduction tank process low-temperature water pipeline pneumatic regulating valve 30 and a reduction tank temperature electric signal are connected into a 01PLC control cabinet 6 through a common cable 17, and the 01PLC control cabinet 6 transmits data into an AA nitrosation control substation 11 through 186 XV1830-3EH10Profibus flexible cables 18 and displays the data.
After an operator starts the system in the AA nitrosation substation 11, the temperature 29 of a nitrosation reaction kettle is respectively set to 42.5 ℃ and the temperature 32 of a reduction tank is respectively set to 40.0 ℃ in the substation, and when the feedback temperature in the substation reaches the set temperature, the flow rates of a sodium nitrite pipeline 23 and an AT-SO4 pipeline 24 are respectively set to 1300L/h and 1700L/h to start the nitrosation reaction. During the reaction, the operator judges the reaction end point every 5-10min on site, and then corrects the flow set values of the sodium nitrite pipeline 23 and the AT-SO4 pipeline 24 in the substation system until the reaction is finished. During the period, the 01PLC control cabinet 6 collects data of the nitrosation reaction kettle 29 and the reduction tank field temperature transmitter 32 every 500ms, the CPU in the 01PLC control cabinet 6 compares the collected data with a preset temperature value, and controls the opening of the pneumatic regulating valve 27 on the nitrosation reaction kettle process low-temperature water pipeline and the opening of the pneumatic regulating valve 30 on the reduction tank process low-temperature water pipeline according to the comparison result until the collected values are equal to the set temperature value.
In the FAA remote control system shown in FIG. 4, the pneumatic solenoid valve 33 of the process low-temperature water pipe from the acylation tank, the pneumatic solenoid valve 34 of the process low-temperature water pipe into the acylation tank, the pneumatic regulating valve 35 of the steam inlet pipe, the temperature transmitter 37 of the acylation tank, the pneumatic solenoid valve 38 of the exhaust pipe, the pneumatic solenoid valve 39 of the process compressed air pipe of the acylation tank interlayer, the pneumatic solenoid valve 40 of the process vacuum pipe, the pneumatic solenoid valve 41 of the acylation tank interlayer, the pneumatic solenoid valve 42 of the exhaust steam water pipe, the pneumatic solenoid valve 43 of the process low-temperature water recovery pipe, the pneumatic solenoid valve 44 of the process compressed air pipe, the pneumatic solenoid valve 46 of the cooler process low-temperature water and the vacuum pump 47 are connected to the 01PLC control cabinet 6 through a common cable 17, and the 01PLC control cabinet 6 transmits data into the FAA acylation control substation 9 through the 6XV 1830.
The operation staff firstly put each reaction material into the acylation tank 33, then enter the FAA acylation control substation 9 starting system, and the CPU in the 01PLC control cabinet 6 selects the methyl formate reaction method or the formic acid reaction method according to the instruction input by the operation staff.
After selecting a methyl formate reaction method, automatically setting the temperature transmitter 37 of the acylation tank to be 35 ℃ by a CPU in the 01PLC control cabinet 6, simultaneously opening the pneumatic electromagnetic valve 34 and the pneumatic electromagnetic valve 43 of the process low-temperature water recovery pipeline, collecting data of the temperature transmitter 37 of the acylation tank every 500ms, and starting timing for 1h by the CPU in the 01PLC control cabinet 6 when the collected data reach 30 ℃; after timing is finished, the CPU in the 01PLC control cabinet 6 opens the pneumatic electromagnetic valve 33 and the pneumatic electromagnetic valve 44 of the process compressed air pipeline, timing is carried out for 20min, then the pneumatic regulating valve 42 is opened, meanwhile, the temperature transmitter 37 of the acylation tank is automatically set to 83 ℃, 37 acylation tank temperature data is collected once every 500ms, when the collected data reaches 80 ℃, the CPU in the 01PLC control cabinet 6 starts timing for 1h, when the collected data of the temperature transmitter 37 of the acylation tank reaches 83 ℃, the CPU in the 01PLC control cabinet 6 regulates the opening of the pneumatic regulating valve 35 of the steam inlet pipeline, and the temperature in the tank is maintained between 80 ℃ and 85 ℃; after the timing is finished, an operator remotely opens the pneumatic electromagnetic valve 40 and the vacuum pump 47 in the FAA acylation control substation 9, reduced pressure distillation is started until the sampling measured density is 1.14-1.20g/ml (78-83 ℃), the end point of the acylation reaction is qualified by sample sending measurement, finally the operator remotely controls the electromagnetic valve 44 to press materials to the next process, and the control of the methyl formate method is finished.
After selecting the formic acid reaction method, the CPU in the 01PLC control cabinet 6 firstly opens the pneumatic electromagnetic valve 33 and the pneumatic electromagnetic valve 44 of the process compressed air pipeline and times for 20min, then opens the pneumatic adjusting valve 42 and simultaneously automatically sets the temperature of the acylation tank to 83 ℃, the temperature data of the acylation tank is collected every 500ms, when the collected data reaches 80 ℃, the CPU in the 01PLC control cabinet 6 starts to time for 2h, and the rest is the methyl formate method.
In the MAA remote control system shown in FIG. 5, a concentrated methanol discharging pipeline pneumatic solenoid valve 51, a concentrated sulfuric acid pipeline pneumatic solenoid valve 52, a methylation solution feeding pipeline pneumatic solenoid valve 53, an MAA hydrolysis tank temperature transmitter 54, an MAA hydrolysis tank interlayer pressure transmitter 55, an MAA hydrolysis tank interlayer steam pipeline pneumatic regulating valve 58, a distillation tower top temperature transmitter 61, a distillation tower top pressure transmitter 62, a condenser process low-temperature water pipeline pneumatic solenoid valve 63, a distillation tower reflux pipeline flow meter 64, a distillation tower discharging pipeline flow meter 65, a discharging pipeline pneumatic regulating valve 66, a methyl formate discharging pipeline pneumatic solenoid valve 67, a dilute methanol discharging pipeline pneumatic solenoid valve 68 and an MAA hydrolysis discharging pipeline pneumatic solenoid valve 7 are connected to a 02PLC control cabinet 7 through a common cable 17, the 02PLC control cabinet 7 then transmits the data to the MAA hydrolysis control substation 15 via the 6XV1830-3EH10Profibus flexible cable 18 and displays it.
An operator firstly opens the pneumatic solenoid valve 53 remotely, after the manual check of feeding is finished, the material ratio is input into the MAA hydrolysis control substation 15, the CPU in the 02PLC control cabinet 7 controls the solenoid valve 51 and the concentrated sulfuric acid pipeline pneumatic solenoid valve 52 to be opened and closed according to instructions to complete feeding, then the CPU automatically opens the pneumatic regulating valve 58 and controls the pneumatic regulating valve 66 to open the pneumatic solenoid valve 63 and the methyl formate pipeline pneumatic solenoid valve 67, the CPU in the 02PLC control cabinet 7 collects the temperature transmitter 61 data at the top of the distillation tower once every 500ms and continuously controls the opening of the pneumatic regulating valve 66 to maintain the temperature data of the temperature transmitter 61 at the top of the distillation tower at 30-60 ℃, when the temperature of the temperature transmitter 61 at the top of the distillation tower exceeds 60 ℃, after the manual confirmation, the CPU in the 02PLC control cabinet 7 closes the methyl formate pipeline pneumatic solenoid valve 67 and opens the dilute methanol pipeline pneumatic solenoid valve 68, and collecting data of the distillation tower top temperature transmitter 61 once every 500ms, continuously controlling the opening of the pneumatic control valve 66 in the period, keeping the temperature data of the distillation tower top temperature transmitter 61 at 60-90 ℃, when the temperature of the distillation tower top temperature transmitter 61 exceeds 90 ℃, prompting operation workers by the MAA hydrolysis control substation 15, and finishing control after confirmation.
Claims (1)
1. A analgin production process control system based on computer control is characterized by comprising the following components: 01PLC control cabinet (6), 02PLC control cabinet (7), AT methylation hydrolysis substation (8), FAA methylation substation (10), MAA neutralization substation (13), condensation-finished product substation (14), AA nitrosation control substation (11), FAA acylation control substation (9), MAA hydrolysis control substation (15), analgin station (16), fiber switch (12) and field instrument (71);
in the AA remote control system, a sodium nitrite pipeline flow meter (23), a sodium nitrite pipeline pneumatic regulating valve (24), an AT-SO4 pipeline flow meter (25), an AT-SO4 pipeline pneumatic regulating valve (26), a nitrosation reaction kettle process low-temperature water pipeline pneumatic regulating valve (27), the temperature in the nitrosation reaction kettle tank (29), a reduction tank process low-temperature water pipeline pneumatic regulating valve (30) and a reduction tank temperature electric signal are connected to a 01PLC control cabinet (6) through a common cable (17), and the 01PLC control cabinet (6) transmits data into an AA nitrosation control substation (11) through a flexible cable (18) and displays the data; after a system is started in an AA nitrosation substation (11), firstly, respectively setting the temperature (29) in a nitrosation reaction kettle to be 42.5 ℃ and the temperature (32) in a reduction tank to be 40.0 ℃ in the substation, and when the feedback temperature in the substation reaches the set temperature, respectively setting the flow rates of a sodium nitrite pipeline flowmeter (23) and an AT-SO4 pipeline flowmeter (25) to be 1300L/h and 1700L/h to start nitrosation reaction; during the reaction, a 01PLC control cabinet (6) collects data of the temperature (29) in a nitrosation reaction kettle and the temperature (32) in a reduction tank once every 500ms, a CPU in the 01PLC control cabinet (6) compares the collected data with a preset temperature value, and controls the opening of a pneumatic regulating valve (27) of a low-temperature water pipeline of a nitrosation reaction kettle process and a pneumatic regulating valve (30) of a low-temperature water pipeline of a reduction tank process according to the comparison result until the collected values are equal to the set temperature value;
in an FAA remote control system, an acylation tank outlet process low-temperature water pipeline pneumatic electromagnetic valve (33), a process inlet low-temperature water pipeline pneumatic electromagnetic valve (34), a steam inlet pipeline pneumatic adjusting valve (35), an acylation tank temperature transmitter (37), an exhaust pipeline pneumatic electromagnetic valve (38), an acylation tank interlayer process air pressure pipeline pneumatic electromagnetic valve (39) and a process vacuum pipeline pneumatic electromagnetic valve (40), an acylation tank interlayer pressure transmitter (41), a steam exhaust pipeline pneumatic solenoid valve (42), a process low-temperature water recovery pipeline pneumatic solenoid valve (43), a process compressed air pipeline pneumatic solenoid valve (44), a cooler process low-temperature water pneumatic solenoid valve (46) and a vacuum pump (47) are connected into a 01PLC control cabinet (6) through a common cable (17), and the 01PLC control cabinet (6) transmits data into an FAA acylation control substation (9) through a flexible cable (18) and displays the data; putting each reaction material into an acylation tank, then entering an FAA acylation control substation (9) to start a system, and selecting a methyl formate reaction method or a formic acid reaction method by a CPU (central processing unit) in a 01PLC (programmable logic controller) control cabinet (6) according to an instruction input by an operator; after selecting a methyl formate reaction method, automatically setting a temperature transmitter (37) of an acylation tank to 35 ℃ by a CPU in a 01PLC control cabinet (6), simultaneously opening a pneumatic electromagnetic valve (34) of a process low-temperature water inlet pipeline and a pneumatic electromagnetic valve (43) of a process low-temperature water recovery pipeline, collecting data of the temperature transmitter (37) of the acylation tank once every 500ms, and starting timing for 1h by the CPU in the 01PC control cabinet (6) when the collected data reach 30 ℃; after timing is finished, a CPU in a 01PLC control cabinet (6) opens a pneumatic electromagnetic valve (33) of a process low-temperature water pipeline and a pneumatic electromagnetic valve (44) of a process air pressure pipeline of an acylation tank, the time is counted for 20min, then opens a pneumatic electromagnetic valve (42) of an exhaust steam water pipeline, simultaneously and automatically sets a temperature transmitter (37) of the acylation tank to be 83 ℃, data of the temperature transmitter (37) of the acylation tank is collected once every 500ms, when the collected data reaches 80 ℃, the CPU in the 01PLC control cabinet (6) starts timing for 1h, when the collected data of the temperature transmitter (37) of the acylation tank reaches 83 ℃, the CPU in the 01PLC control cabinet (6) adjusts the opening of a pneumatic adjusting valve (35) of a steam inlet pipeline, and the temperature in the tank is maintained between 80 ℃ and 85 ℃; after timing is finished, an operator remotely opens a pneumatic electromagnetic valve (40) and a vacuum pump (47) of a process vacuum pipeline in an FAA acylation control substation (9) and starts to carry out reduced pressure distillation until the density is 1.14-1.20g/ml (78-83 ℃) after sampling and measuring; after selecting a formic acid reaction method, a CPU in a 01PLC control cabinet (6) firstly opens a pneumatic electromagnetic valve (33) of a process low-temperature water pipeline and a pneumatic electromagnetic valve (44) of a process compressed air pipeline of an acylation tank, the time is kept for 20min, then opens a pneumatic electromagnetic valve (42) of an exhaust steam water pipeline, the temperature of the acylation tank is automatically set to 83 ℃, the temperature data of the acylation tank is collected once every 500ms, and the CPU in the 01PLC control cabinet (6) starts to time for 2h when the collected data reach 80 ℃;
in an MAA remote control system, a concentrated methanol discharge pipeline pneumatic solenoid valve (51), a concentrated sulfuric acid pipeline pneumatic solenoid valve (52), a methylated liquid feed pipeline pneumatic solenoid valve (53), an MAA hydrolysis tank temperature transmitter (54), an MAA hydrolysis tank interlayer pressure transmitter (55), an MAA hydrolysis tank interlayer steam pipeline pneumatic regulating valve (58), a distillation tower top temperature transmitter (61), a distillation tower top pressure transmitter (62), a condenser process low-temperature water pipeline pneumatic solenoid valve (63), a distillation tower reflux pipeline flowmeter (64), a distillation tower discharge pipeline flowmeter (65), a discharge pipeline pneumatic regulating valve (66), a methyl formate discharge pipeline pneumatic solenoid valve (67), a dilute methanol discharge pipeline pneumatic solenoid valve (68) and an MAA hydrolysis exhaust pipeline pneumatic solenoid valve (7) are connected into a 02PLC control cabinet (7) through a common cable (17), then the 02PLC control cabinet (7) transmits the data into the MAA hydrolysis control substation (15) through a flexible cable (18) and displays the data; firstly, remotely opening a methylation solution feeding pipeline pneumatic electromagnetic valve (53), after the feeding is checked, inputting the material ratio into an MAA hydrolysis control substation (15), controlling the pneumatic electromagnetic valve (51) of a concentrated methanol discharging pipeline and the pneumatic electromagnetic valve (52) of a concentrated sulfuric acid pipeline to be opened and closed by a CPU in a 02PLC control cabinet (7) according to instructions to complete the feeding, then automatically opening a pneumatic adjusting valve (58) of an MAA hydrolysis tank interlayer steam pipeline and controlling the pneumatic adjusting valve (66) of the discharging pipeline, opening a pneumatic electromagnetic valve (63) of a condenser process low-temperature water pipeline and a pneumatic electromagnetic valve (67) of a methyl formate discharging pipeline, collecting the data of a distillation tower top temperature transmitter (61) once every 500ms by the CPU in the 02PLC control cabinet (7), and continuously controlling the opening size of the pneumatic adjusting valve (66) of the discharging pipeline to ensure that the temperature data of the distillation tower top temperature transmitter (61) is maintained, when the temperature of the distillation tower top temperature transmitter (61) exceeds 60 ℃, after manual confirmation, a CPU in a 02PLC control cabinet (7) closes a methyl formate pipeline pneumatic electromagnetic valve (67), opens a dilute methanol pipeline pneumatic electromagnetic valve (68), collects the distillation tower top temperature transmitter (61) data every 500ms, continuously controls the opening size of a discharge pipeline pneumatic adjusting valve (66) in the period, maintains the temperature data of the distillation tower top temperature transmitter (61) at 60-90 ℃, when the temperature of the distillation tower top temperature transmitter (61) exceeds 90 ℃, an MAA hydrolysis control substation (15) prompts, and after confirmation, the control is finished.
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| CN201810751741.1A CN108958190B (en) | 2018-07-10 | 2018-07-10 | Analgin production process control system based on computer control |
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| CN201810751741.1A CN108958190B (en) | 2018-07-10 | 2018-07-10 | Analgin production process control system based on computer control |
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| CN102584707B (en) * | 2012-01-18 | 2014-11-26 | 河北冀衡（集团）药业有限公司 | Production method of analgin bulk drug |
| CN102627608B (en) * | 2012-03-31 | 2014-03-26 | 武汉武药制药有限公司 | Preparation method for analgesic and antipyretic drug-analgin |
| CN203007177U (en) * | 2012-12-31 | 2013-06-19 | 河北冀衡（集团）药业有限公司 | Antipyrine production system |
| CN203625269U (en) * | 2013-12-09 | 2014-06-04 | 山东新华制药股份有限公司 | 4-amino-antipyrine production device |
| CN206773457U (en) * | 2017-04-21 | 2017-12-19 | 天津港石油化工码头有限公司 | Automatic monitoring system for petrochemical terminal production |
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