CN1089473A - Compound henbane seed injection to artery or vein and method for making thereof - Google Patents
Compound henbane seed injection to artery or vein and method for making thereof Download PDFInfo
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- CN1089473A CN1089473A CN 93107252 CN93107252A CN1089473A CN 1089473 A CN1089473 A CN 1089473A CN 93107252 CN93107252 CN 93107252 CN 93107252 A CN93107252 A CN 93107252A CN 1089473 A CN1089473 A CN 1089473A
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- injection
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- troxerutin
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Abstract
A kind of compound henbane seed injection to artery or vein and preparation method thereof, this injection of every 10ml contain hydrochloric acid mountain gelsemium henbane alkali 30-80mg, scopolamine hydrobromide 0.3-1.5mg, troxerutin 0.1-0.4g, glucose 200-400mg.Its preparation method is that to mix, bottle, seal, sterilize, inspect by random samples qualified back successively by the order of troxerutin-hydrochloric acid mountain gelsemium henbane alkali-scopolamine hydrobromide-glucose standby.This injection for treating epilepsy and brain sequela have special effect.
Description
The present invention has introduced a kind of Chinese patent medicine and preparation method thereof, is specifically related to a kind of compound henbane seed injection to artery or vein and preparation method thereof.
Described compound recipe Semen Hyoscyami injection is a kind of from removing the angle of cerebral microcirculation disturbance, adopts artery and vein in conjunction with the method for injecting, the medicine of treatment epilepsy and brain sequela.The computer international online retrieval shows, this medicine and preparation method thereof, and this medicinal method for the treatment of above-mentioned disease be there is no report.
Task of the present invention is a kind of compound henbane seed injection to artery or vein epilepsy and encephalopathy sequela, that can carry out the arteriovenous injection and preparation method thereof that is used for the treatment of of exploitation.
(with the cubage in every 10ml solution) composed as follows of described injection:
Hydrochloric acid anisodamine 30-80mg
Hyoscine hydrobromide 0.3-1.5mg
Troxerutin (extracting) 0.1-0.4g by the Flos Sophorae Immaturus
Glucose 200-400mg
All the other are distilled water.
The composition that this injection plays a major role is hydrochloric acid anisodamine and hyoscine hydrobromide, and they are the active ingredients of extracting from the Chinese herbal medicine Semen Hyoscyami, can buy finished product from many pharmaceutical factories (as Hangzhou people's livelihood pharmaceutical factory, Beijing Pharmaceutical Factory No.3) at present.Troxerutin and glucose all can have been bought from pharmacy.
The preparation method of this injection is as follows:
1. successively said components is dissolved in the distilled water at normal temperatures and pressures according to the above ratio, its order is troxerutin-hydrochloric acid anisodamine-hyoscine hydrobromide-glucose;
2. mix, remove insoluble matter;
3. on filling machine, pack in the vial of 10ml, on sealing machine, seal;
4. sterilization is extremely aseptic in medical high pressure sterilizer;
5. random inspection is up to the standards.
This medicine is a light yellow transparent liquid, and its qualitative identification method is as follows:
1. get this product 2ml and add 5 of concentrated nitric acids, put evaporate to dryness in the water-bath, the alcoholic solution that addend drips potassium hydroxide on residual solids promptly is rufous.
2. get this product 1ml, add water 10ml, add a spot of alumina solution and be yellow.
3. this injection is slowly splashed in the warm alkali cupric tartrate reagent, brown precipitate promptly takes place.
4. this injection shows the identification of oxide, sees the 32nd page of two appendix of Chinese Pharmacopoeia version in 1985.
5. PH is 3.5-5.0 after measured.
Active component detects as follows:
(1). total hyoscyami alkali amount (the 20th page of two appendix of Chinese Pharmacopoeia version in 1985)
Precision is measured this product 1ml, puts in the volumetric flask of 50ml, and thin up shakes up to scale.Measure 2ml with the pipet precision, put into separatory funnel, adding this solution compound method of bromine cresol solutions of chlorine 4ml(for preparing in advance again is: get bromine cresol chlorine 50mg, adding concentration is the NaCl aqueous solution 1.6ml of 0.2mol/L, dissolving back thin up is to 100ml, the elimination post precipitation is standby in case of necessity), shake up, add the 10ml chloroform with pipet, after the shaking out, leave standstill layering after 1 hour, divide and get chloroform extraction liquid, with its trap of spectrophotometry, be the 420nm place at wavelength, its trap should be between 0.42-0.5.
(2). troxerutin (ditto)
Get this product 1ml with pipet, put into the volumetric flask of 50ml, be diluted with water to scale, shake up, the reuse pipet is got its solution 5ml, places the volumetric flask of 50ml, is diluted to scale with water, use spectrophotometry, at wavelength 255 ± 1mm place, its trap should be between 0.48-0.55.
(3). other conforms to the every relevant every regulation down of two appendix P4-5 injections of Chinese Pharmacopoeia version in 1985.
Prop up or 5ml/ props up packing by 10ml/, airtight, shading, shady and cool place preserve.
This medicine behind animal experiment in the clinical trial of having advanced letter of Pinglu County, Shanxi Province epileptics branch of institute of traditional Chinese medicine.Controlled trial shows, for epileptics, adopts the other drug treatment, and total effective rate has only 34.8%.The patient that this institute receives is the patient by invalid after method in common and the Drug therapy or poor effect basically, use medicine of the present invention after, through 10,000 person-times of statistics, its total effective rate has improved 38.8% up to 83.6%.
For lose after the encephalopathy sick at present both at home and abroad medical circle all think irreversiblely, so curative effect does not have unified radix, after medicine treatment of the present invention, effective percentage can reach more than 60%.
Now introduce two model cases.
Section certain, the man, 12 years old, because of when birth difficult labour, suffocate.Suffered from epilepsy and brain sequela 12 years, epilepsy is shown effect 7-9 time every day when being admitted to hospital in 86 years, and is not sociable, can not stand, and dementia be can't take care of oneself.Through the treatment of two courses of treatment, epilepsy is controlled over 6 years, and life now can be taken care of oneself the reading of having gone to school.
Thunder, the woman 16 years old, goes into a coma a couple of days when coming institute, can not sit, stand, more can not walk, run, gatism, epilepsy is shown effect several white time every day the most for a long time, behind injection compound recipe Semen Hyoscyami injection first pin, epilepsy is promptly controlled, can freely run after the 12nd day in the 6th day followingly.
Zhao, the man, 7 years old, come institute to suffer from meningitis before 52 days, once went into a coma continuously 35 days, a smart and lovely child has become the plant man, and is not sociable, can not walk, and is not familiar with the household, can't take care of oneself.Through two course of therapy, infant intelligence is recovered substantially, runs freely, has returned to school.
Claims (2)
1, a kind of compound henbane seed injection to artery or vein is characterized in that by following medicine be composited (with the cubage in every 10ml solution):
Hydrochloric acid mountain gelsemium henbane alkali 30-80mg
Scopolamine hydrobromide 0.3-1.5mg
Troxerutin 0.1-0.4g
Glucose 200-400mg
All the other are distilled water.
2, the preparation method of injection according to claim 1 is characterized in that being made of the following step:
(1). successively described medicine is dissolved in the distilled water at normal temperatures and pressures in described ratio, its precedence is: troxerutin-hydrochloric acid anisodamine-hyoscine hydrobromide-glucose,
(2). mix, leave standstill, precipitation is removed insoluble matter,
(3). in the vial of the 10ml that on filling machine, packs into, on sealing machine, seal,
(4). in medical high pressure sterilizer, sterilize to aseptic,
(5). randomness is made a random inspection qualified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93107252 CN1089473A (en) | 1993-01-03 | 1993-06-17 | Compound henbane seed injection to artery or vein and method for making thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93100035.1 | 1993-01-03 | ||
| CN93100035 | 1993-01-03 | ||
| CN 93107252 CN1089473A (en) | 1993-01-03 | 1993-06-17 | Compound henbane seed injection to artery or vein and method for making thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1089473A true CN1089473A (en) | 1994-07-20 |
Family
ID=25742971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93107252 Pending CN1089473A (en) | 1993-01-03 | 1993-06-17 | Compound henbane seed injection to artery or vein and method for making thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1089473A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001043745A1 (en) * | 1999-12-17 | 2001-06-21 | Fundação De Amparo Á Pesquisa Do Estado De São Paulo - Fapesp | The use of scopolamine salts |
| KR100736505B1 (en) | 1999-12-17 | 2007-07-06 | 푼다싸웅 지 앙빠루 아 뻬스끼자 두 에스따두 지 싸웅 파울루 - 에피아뻬에에씨뻬 | The use of scopolamine salts |
| CN102366402A (en) * | 2011-09-28 | 2012-03-07 | 河南辅仁怀庆堂制药有限公司 | Scopolamine hydrobromide injection and production technology |
-
1993
- 1993-06-17 CN CN 93107252 patent/CN1089473A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001043745A1 (en) * | 1999-12-17 | 2001-06-21 | Fundação De Amparo Á Pesquisa Do Estado De São Paulo - Fapesp | The use of scopolamine salts |
| JP2003530315A (en) * | 1999-12-17 | 2003-10-14 | フンダソン・デ・アンパロ・アペスキーザ・ド・エスタード・デ・サンパウロ（Ｆａｐｅｓｐ） | Use of scopolamine salt |
| KR100736505B1 (en) | 1999-12-17 | 2007-07-06 | 푼다싸웅 지 앙빠루 아 뻬스끼자 두 에스따두 지 싸웅 파울루 - 에피아뻬에에씨뻬 | The use of scopolamine salts |
| CN102366402A (en) * | 2011-09-28 | 2012-03-07 | 河南辅仁怀庆堂制药有限公司 | Scopolamine hydrobromide injection and production technology |
| CN102366402B (en) * | 2011-09-28 | 2013-03-27 | 河南辅仁怀庆堂制药有限公司 | Scopolamine hydrobromide injection and production technology |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |