CN108938936A - A kind of Chinese medicine preparation for treating facial neuritis - Google Patents

A kind of Chinese medicine preparation for treating facial neuritis Download PDF

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Publication number
CN108938936A
CN108938936A CN201811220531.6A CN201811220531A CN108938936A CN 108938936 A CN108938936 A CN 108938936A CN 201811220531 A CN201811220531 A CN 201811220531A CN 108938936 A CN108938936 A CN 108938936A
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rhizoma
chinese medicine
facial
facial neuritis
neuritis
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张爱梅
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The present invention relates to field of traditional Chinese medicine technology, in particular to a kind of Chinese medicine for controlling facial neuritis is made by following bulk pharmaceutical chemicals: rhizoma typhonii 10g, river silkworm 10g, scorpio 6g, root of Dahurain angelica 6g, asarum 6g, Radix Angelicae Sinensis 6g, rhizoma arisaematis 10g, Rhizoma Gastrodiae 15g, rhizome of chuanxiong 6g, Rhizoma Et Radix Notopterygii 6g.Decoction, one one, treats facial neuritis good effect, quickly effective, with strong points and without side-effects.

Description

A kind of Chinese medicine preparation for treating facial neuritis
Technical field
The present invention relates to tcm clinical practice facial neuritis disease treatment fields.Specifically caused for treating facial neuritis Facial paralysis and facial paralysis Chinese medicine.
Background technique
Facial neuritis is commonly called as facioplegia (i.e. facial paralysis), " crooked mouth ", " facial paralysis ", is with facial expression muscle Group's dyskinesia is a kind of disease of main feature.Modern medicine is not yet clear to this disease cause of disease, and result is aobvious by inquiry Show there is the patient of nearly half because part by wind or is caught a cold due to onset, thus have been generally acknowledged that may be local nerve blood vessel because by Chill and spasm occurs, cause facial nerve tissue ischemic, oedema, compression and cause a disease.Modern medicine thinks facial neuritis mostly because of wind Cold, virus infection and autonomic nervous function are unstable etc. causes local nerve vasopasm, leads to neural ischemia oedema, keeps face refreshing Occurred caused by myelinoclasis or even axonal degeneration.And the first of inducement seniority among brothers and sisters is ranked by wind or the stimulation such as catch a cold in part Name.The clinical manifestation of facial paralysis is: onset is unexpected, and spring and autumn is more.Normal wind history of suffering from cold, or have virus infection history.It is unilateral or double Side surface part mimetic muscle is paralysed suddenly, sick side volume line disappears, and palpebral fissure cannot be closed, and nasolabial groove shoals, ptosis of labial angle, the drum cheek, mouthpiece The gas leakage when whistle, food are easily stranded between the tooth cheek of disease side, can be with 2/3 ageusia before sick side tongue, hyperakusis, more tears etc..At present Domestic city face paralysis disease incidence is 38.0/10 ten thousand populations, and rural area is 26.0/10 ten thousand populations.
The treatment method of facial paralysis caused by traditional Chinese and western medicine clinic common treatment facial neuritis is as follows at present: western medical treatment is to change Kind local blood circulation mitigates facial nerve oedema, alleviates nerve compression, promotes the drug of neurological functional recovery, for example, fill in rice The drug therapies such as pine, acyclovir, B family vitamin；Chinese medicine is treated with acupuncture or prescription Qianzheng San.It is controlled through above-mentioned traditional Chinese and western medicine Different according to the degree of face paralysis after treatment, about 10%~30% patient can leave different degrees of complication and sequelae, such as Synkinesia, facial spasm, facial muscle contracture, crocodile tear etc..Considerable distress is all brought to patient body and spirit.
Summary of the invention
In order to solve the problems, such as that facial paralysis caused by facial neuritis and facial paralysis are difficult to eradicate, the present invention provides one kind The Chinese medicine preparation for treating facial neuritis.
The present invention is achieved by the following measures:
A kind of Chinese medicine for treating facial neuritis, is made by following bulk pharmaceutical chemicals:
Rhizoma typhonii 10g, river silkworm 10g, scorpio 6g, root of Dahurain angelica 6g, asarum 6g, Radix Angelicae Sinensis 6g, rhizoma arisaematis 10g, Rhizoma Gastrodiae 15g, rhizome of chuanxiong 6g, Rhizoma Et Radix Notopterygii 6g.
The Chinese medicine, bulk pharmaceutical chemicals are mixed, and the water of 5-7 times of weight is added to impregnate 30-40 minutes, 40-50 points of heating tanning Clock, filtering, the water for adding 4-5 times of weight of filter residue boil 30-40 minutes, and filtering, merging filtrate, being concentrated into relative density is 1.4。
One dose per day.
Rhizoma typhonii: acrid flavour, it is warm-natured, it is toxic；Return stomach, Liver Channel；With wind-dispelling phlegm, degrading the channel, the effect of relieving pain of detoxifying.
Scorpio: antispastic cramp and relieves dizziness, is removed obstruction in channels to relieve pain at anti-inflammatory and attacked poison.
The root of Dahurain angelica: being used as medicine with root, the functions such as the dehumidifying that gets rid of illness, apocenosis myogenic, promoting blood circulation and stopping pain.
Asarum: it is acrid in flavour and warm in nature, it is slightly poisonous；With the effect of relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warming lung and resolving fluid.
Radix Angelicae Sinensis: its root can be used as medicine, and be one of most common Chinese medicine.With benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine resists Cancer, anti-ageing the effect of preventing always, is immune.
Rhizoma arisaematis: removing toxicity for detumescence, dispelling wind and relieving convulsion, reducing phlegm and resolving masses；It cures mainly facioplegia, hemiplegia, child convulsion, break Cold, Dian Epilepsy；External curing pyogenic infections from tumour or sore, venomous snake bite, fly eradication maggot.
Rhizoma Gastrodiae: also known as rhizoma gastrodiae, from mother, it is sweet in flavor, pungent, it is mild-natured.Return liver warp.Function relieving convulsion and spasm Pinggan Yang, dispelling wind and removing obstruction in the meridians.It is main Anxious chronic infantile convulsion is controlled, muscular constricture of twitching, tetanus, dizziness and headache, hemiplegia, limb fiber crops, rheumatic arthralgia.Aid yang qi mends general debility, Promoting blood circulation, main intermittent headache of having one's ideas straightened out, headache, dizzy void Ni, the strong convulsion of epilepsy, four limbs contraction is anxious, and language has some setbacks, all apoplexy, the card such as wind phlegm.
Rhizome of chuanxiong: pungent scattered temperature is logical, can activating microcirculation and removing stasis medicinal and promoting qi circulation and relieving pain for " the gas medicine in blood " have sensible qi and blood function Effect, therefore control all pains of the chest side of body of qi depression to blood stasis, abdomen.
Rhizoma Et Radix Notopterygii: rhizome and root are medicinal, warm-natured, dispellieg cold and dampness, are used for affection of exogenous wind-cold, headache and adiapneustia, cold-dampness numbness, upper limb arthritis pain Bitterly.
Embodiment
A kind of Chinese medicine for treating facial neuritis, is made by following bulk pharmaceutical chemicals:
Rhizoma typhonii 10g, river silkworm 10g, scorpio 6g, root of Dahurain angelica 6g, asarum 6g, Radix Angelicae Sinensis 6g, rhizoma arisaematis 10g, Rhizoma Gastrodiae 15g, rhizome of chuanxiong 6g, Rhizoma Et Radix Notopterygii 6g.
The Chinese medicine, bulk pharmaceutical chemicals are mixed, and the water of 5-7 times of weight is added to impregnate 30-40 minutes, 40-50 points of heating tanning Clock, filtering, the water for adding 4-5 times of weight of filter residue boil 30-40 minutes, and filtering, merging filtrate, being concentrated into relative density is 1.4。
One dose per day.
Clinical effectiveness verifying
1, case-data:
Male 25, women 25, the age, average age was 55.5 years old, and all selected patients all suffer from not between 40-70 years old With the facial neuritis of degree, wherein there is 33 to have unilateral facial paralysis symptom to occur, 10 have the appearance of facial diplegia symptom, 7 patients There are the sequelae such as facial spasm or facial muscle contracture.
2, therapeutic scheme
Patient is divided between two groups, two groups according to symptom and age, gender without obvious statistical difference.One group is experiment Group, one group is control group, and wherein experimental group contains 16 patients for having unilateral facial paralysis, 5 be facial diplegia patient, 4 trouble Person has the sequelae such as facial spasm or facial muscle contracture.Control group contains 17 patients for having unilateral facial paralysis, and 5 are facial diplegias Patient, 3 patients have the sequelae such as facial spasm or facial muscle contracture.Two groups of patient ages, gender, symptom, sign and items are real Test room index there are no significant difference (P > 0.05).
Experimental group is treated using Chinese medicine of the invention, one dose per day.
Control group is treated using the acupuncture in conventional therapy means.
7 days as a course for the treatment of, and treatment cycle is 3 courses for the treatment of.
3, curative effect determinate standard
Before the treatment according to Chinese stroke scale (CSS) [2], it is scored when treating 15d, 30d and determines curative effect.Clinical efficacy Criterion:
Be almost recovered: functional impairment, which scores, reduces 91-100%, and 0 grade of disability degree；
Marked improvement: functional impairment, which scores, reduces 46-90%, and 1 grade -3 grades of disability degree；
Effective: functional impairment scoring reduces 18-45%；
Invalid: functional impairment scoring decreases or increases within 17%；
Deteriorate: increasing by 18% or more.
Measurement data is examined using variance analysis and t, and enumeration data is examined using x2, and P < 0.05 is that difference has conspicuousness.
4, result
Statistics see the table below
As it can be seen that the Chinese medicine for the treatment of facial neuritis of the invention, one one, and facial paralysis good effect is quickly effective, both has and is directed to Property is strong and without side-effects.

Claims (2)

1. a kind of Chinese medicine for treating facial neuritis, it is characterized in that being made by following bulk pharmaceutical chemicals:
Rhizoma typhonii 10g, river silkworm 10g, scorpio 6g, root of Dahurain angelica 6g, asarum 6g, Radix Angelicae Sinensis 6g, rhizoma arisaematis 10g, Rhizoma Gastrodiae 15g, rhizome of chuanxiong 6g, Rhizoma Et Radix Notopterygii 6g.
2. Chinese medicine according to claim 1 adds the water of 5-7 times of weight to impregnate 30-40 it is characterized in that bulk pharmaceutical chemicals are mixed Minute, heating tanning 40-50 minutes, filtering adds the water tanning of 4-5 times of weight of filter residue 30-40 minutes, and filtering merges filter Liquid, being concentrated into relative density is 1.4.
CN201811220531.6A 2018-10-19 2018-10-19 A kind of Chinese medicine preparation for treating facial neuritis Pending CN108938936A (en)

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Application Number Priority Date Filing Date Title
CN201811220531.6A CN108938936A (en) 2018-10-19 2018-10-19 A kind of Chinese medicine preparation for treating facial neuritis

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010000396A (en) * 2000-09-26 2001-01-05 이봉석 whiten toilet-ry
CN101601785A (en) * 2008-06-15 2009-12-16 徐福云 A kind of compound preparation and preparation technology who treats facial paralysis
CN106902257A (en) * 2015-12-22 2017-06-30 邵杰 A kind of Chinese medicine composition of facial paralysis and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010000396A (en) * 2000-09-26 2001-01-05 이봉석 whiten toilet-ry
CN101601785A (en) * 2008-06-15 2009-12-16 徐福云 A kind of compound preparation and preparation technology who treats facial paralysis
CN106902257A (en) * 2015-12-22 2017-06-30 邵杰 A kind of Chinese medicine composition of facial paralysis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
中医研究院广安门医院蒲辅周老中医经验整理小组: "蒲辅周老中医验方选", 《赤脚医生杂志》 *

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