CN108938141A - Circulating inhalation anaesthesia apparatus - Google Patents
Circulating inhalation anaesthesia apparatus Download PDFInfo
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- CN108938141A CN108938141A CN201811133523.8A CN201811133523A CN108938141A CN 108938141 A CN108938141 A CN 108938141A CN 201811133523 A CN201811133523 A CN 201811133523A CN 108938141 A CN108938141 A CN 108938141A
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- 206010002091 Anaesthesia Diseases 0.000 title claims abstract description 125
- 230000037005 anaesthesia Effects 0.000 title claims abstract description 125
- 238000001949 anaesthesia Methods 0.000 title claims abstract description 33
- 239000007789 gas Substances 0.000 claims abstract description 70
- 239000003994 anesthetic gas Substances 0.000 claims abstract description 45
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000001301 oxygen Substances 0.000 claims abstract description 41
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 41
- 238000010521 absorption reaction Methods 0.000 claims abstract description 38
- 239000002912 waste gas Substances 0.000 claims abstract description 38
- 239000003983 inhalation anesthetic agent Substances 0.000 claims abstract description 19
- 230000006698 induction Effects 0.000 claims description 25
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 10
- 229920001971 elastomer Polymers 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 7
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 239000003638 chemical reducing agent Substances 0.000 claims description 4
- 238000005192 partition Methods 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000013013 elastic material Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 17
- 230000003444 anaesthetic effect Effects 0.000 abstract description 17
- 238000000034 method Methods 0.000 abstract description 12
- 238000011084 recovery Methods 0.000 abstract description 7
- 241000700159 Rattus Species 0.000 description 74
- 230000029058 respiratory gaseous exchange Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 238000012423 maintenance Methods 0.000 description 12
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 11
- 229960002725 isoflurane Drugs 0.000 description 11
- 230000036407 pain Effects 0.000 description 11
- 238000005520 cutting process Methods 0.000 description 10
- 238000002350 laparotomy Methods 0.000 description 10
- 238000011160 research Methods 0.000 description 8
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- 210000004369 blood Anatomy 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
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- 230000008569 process Effects 0.000 description 6
- 230000004206 stomach function Effects 0.000 description 6
- 210000001835 viscera Anatomy 0.000 description 6
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 5
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- 241000018646 Pinus brutia Species 0.000 description 5
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- 239000003814 drug Substances 0.000 description 5
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- 210000002784 stomach Anatomy 0.000 description 5
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- 210000000683 abdominal cavity Anatomy 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
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- 206010003497 Asphyxia Diseases 0.000 description 3
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- 238000002474 experimental method Methods 0.000 description 3
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- 238000012544 monitoring process Methods 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 230000003387 muscular Effects 0.000 description 3
- 238000004064 recycling Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 241000282326 Felis catus Species 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
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- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000002695 general anesthesia Methods 0.000 description 2
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 2
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- 206010033675 panniculitis Diseases 0.000 description 2
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- 238000012795 verification Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 101100067761 Rattus norvegicus Gast gene Proteins 0.000 description 1
- 101100284355 Rattus norvegicus Hr gene Proteins 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004373 mandible Anatomy 0.000 description 1
- 210000002050 maxilla Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 210000004877 mucosa Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000012141 orotracheal intubation Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
Abstract
The invention discloses a kind of circulating inhalation anaesthesia apparatus, including oxygen tank, first gas flowmeter, anesthetic gases Volatile anesthetic, mask and waste gas absorption tank；The outlet of oxygen tank is connect with the entrance of first gas flowmeter, and the outlet of first gas flowmeter is connect with the entrance of anesthetic gases Volatile anesthetic；The outlet of anesthetic gases Volatile anesthetic and the outlet of minipump converge to be connect with the entrance of second gas flowmeter and mask afterwards, and big air storage bag is housed on the pipeline before second gas flowmeter.The outlet of mask is connect with waste gas absorption tank entrance and recyclegas filter cartridge entrance respectively, is converged after the outlet of recyclegas filter cartridge and micro vacuum series connection of pumps with the outlet of anesthetic gases Volatile anesthetic and is again introduced into anesthesia access and is recycled.This anesthesia outfit good airproof performance, anaesthetic effect are certain, highly-safe, small to animal physiological Index Influence, can be recycled gas, anesthesia it is high-efficient, anesthesia and recovery time it is easily controllable, the anesthesia procedure suitable for meiofauna.
Description
Technical field
The present invention relates to a kind of anesthesia outfit more particularly to a kind of circulating inhalation anaesthesia apparatus of meiofauna, main
Be used in the scientific researches such as life science, medicine, pharmacology, Food Science, veterinary science and teaching experiment to experimental animal into
Row anesthesia, belongs to meiofauna anesthesia outfit field.
Background technique
Zoopery is in the scientific researches and teaching experiment such as life science, medicine, pharmacology, Food Science, veterinary science
Essential a part, rat are common experimental animals in animal medicine research, in cardiovascular system, drug nutrition generation
It thanks, commonly use rat in geratology, hematology, tumour, radiation biological and immunological investigation as experimental animal model.However
In process of scientific research, it has been found that, it is usually strong because not being resistant in surgical operation not enter into good narcose rat
Pain stimulation and occur struggle, disturbance etc. stress reactions, make scientific research personnel be difficult to complete research process.Even animal protects sometimes
Fixed and anesthesia quality directly decides the success or failure of scientific research.
Research find using inhalation anesthesia rat heart rate and blood oxygen concentration it is more stable, can preferably remain dynamic in art
The heart function of object is horizontal, and inhalation anesthesia mode also has that induction time is short, anesthesia is fast, revival is fast, and depth of anesthesia is easy to control
The advantages of, inhalation anesthesia replaces preferred manner of the injecting anesthetic as general anesthesia gradually.
Current existing inhalation anaesthesia apparatus, applicable animal is mostly the medium-and-large-sized animal such as dog, cat, in anaesthesia process
In, the tracheae for being applicable in trachea cannula and animal is attached, and is not suitable for the meiofaunas such as rat.It is suitble to small-sized moving in spite of part
The small-sized inhalation anaesthesia apparatus that object uses, but these devices are Full-open or semi-open state mostly, thereby result in animal not
The gas used is not filtered to recycle and just be directly discharged in atmosphere, causes the waste of resource and the pollution of environment.
The mask that existing inhalation anaesthesia apparatus uses currently on the market is suitable for the medium-and-large-sized animal such as dog, cat more, and
Seal degree is insufficient, and the nose and mouth of animal are easy to expose from mask.During the general anesthesia of meiofauna, lead to
Often animal head is placed in mask, anesthetic gases is then passed to and carries out anesthesia maintenance, but animal head can not in the process
It is closely coupled with mask, it is leaked to anesthetic gases in air, and then pollute environment, endangers operator's health.Although have to
Rat oral chamber carries out the report of trachea cannula, but operation difficulty is larger, is not easy to popularize (Tomasello G1, Damiani
F,Cassata G,Palumbo VD,Sinagra E,Damiani P,Bruno A,Cicero L,Cupido F,Carini
F,Lo Monte AI.Simple and fast orotracheal intubation procedure in rats.Acta
Biomed.2016,87(1):13-5.).Mask suitable for meiofaunas such as rats is Full-open mostly, and rat is without benefit
Anesthetic gases by recycling, are not directly discharged in air, cause waste and pollution.
Therefore, although simple type rats breathing anesthesia outfit in the prior art can substantially meet the mesh of anesthetized rat anesthesia
, however different degrees of there are following deficiencies:
(1) anesthesia speed is slow, anaesthetizes low efficiency, and anaesthesia process cannot be controlled accurately in real time.
(2) though there is waste gas recovery bottle, anesthetic gases not can be recycled, so that anesthetic utilization rate substantially reduces；
(3) existing apparatus airtightness is bad, especially visor portion, and anesthetic is easily caused to be diffused into air, not only unrestrained
Take anesthetic, also endangers experimenter's health.
In view of status, it is higher that urgent need develops a kind of good airproof performance, highly-safe, gas can be recycled, anesthesia efficiency
Meiofauna multi-path inhalation anaesthesia apparatus.
Summary of the invention
In order to overcome the above-mentioned deficiency of existing rat anesthesia device, the present invention provides a kind of good airproof performance, it is highly-safe,
Ke Xunhuanliyong gas, the anesthesia higher circulating inhalation anaesthesia apparatus for being applicable to rat of efficiency.A kind of good leak tightness, anesthesia
High-efficient, safe handling circulating inhalation anaesthesia apparatus.
To achieve the above object, the technical solution used in the present invention is:
A kind of circulating inhalation anaesthesia apparatus, including oxygen tank, first gas flowmeter, anesthetic gases Volatile anesthetic, mask
With waste gas absorption tank；Wherein, the outlet of oxygen tank is connect by oxygen pressure reducer and pipeline with the entrance of first gas flowmeter,
The outlet of first gas flowmeter is connect by pipeline with the entrance of anesthetic gases Volatile anesthetic, the outlet of the anesthetic gases Volatile anesthetic
It is connected by the entrance of second gas flowmeter and pipeline and mask；The outlet of mask is connect with waste gas absorption tank；It is wherein described
Anesthetic gases Volatile anesthetic outlet also converge with the outlet of a minipump after again successively with second gas flowmeter and face
The entrance of cover connects；The entrance of the minipump is connect after filtering cassette in series with a recyclegas with the outlet of mask；At this
Big air storage bag is housed on the outlet conduit of minipump.
Since the tidal volume of rat is smaller, most of oxygen and isoflurane are not sucked by rat, so this anesthesia outfit
By setting minipump, recyclegas filter cartridge and waste gas absorption tank, these devices and anesthetic gases Volatile anesthetic and
Mask forms an anesthetic gases circulator, the unabsorbed anesthetic gases of rat and circulating oxygen can be utilized；By
The outlet installation minipump of recyclegas filter cartridge can give recyclegas filter cartridge certain draft, and gas is made to keep single
To circulation；The recyclegas of recyclegas filter cartridge is not entered, then waste gas absorption tank is entered by active carbon therein by pipeline
Absorption；Therefore, this anesthesia outfit can fully absorb the CO of animal exhalation2, repeatable inhalation anesthesia gas, anaesthetic, humidifying,
Air flue is warmed up, tracheal mucosa is protected, has the characteristics that hemicompact enclosed breathing circuit and advantage.
In anesthesia maintenance, dosed portions flowmeter is adjusted, oxygen input flow rate 0.15L/min is made；Face is adjusted simultaneously
Cover portion shunt meter gas flow be 0.2L/min, and by isoflurane concentration adjust to 2.5%, then by a digital pressure gauge with
Waste gas absorption pipe end is connected, and by adjusting micro vacuum flow rate pump, makes the pressure of waste gas absorption pipe end close to 0, then
Waste gas absorption pipe is connected into waste gas absorption tank again, the anesthetic gases not sucked by rat can in this way re-used, to reduce
The loss of exhaust gas discharge and anesthetic gases, improves the utilization rate of anesthetic gases.It is found in operation verifying, in this way
Maintenance anesthesia is carried out to rat, rats breathing is in good condition, and breathing is steady, and Visual mucous membrane color is normal, and blood oxygen can maintain
98% or more.
As a kind of preferred embodiment of the circulating inhalation anaesthesia apparatus of the present invention, the recyclegas filter cartridge
It is preferred that using acrylic box, two chambers are divided into using partition between the both ends of the acrylic box, are used between two chambers
It connects, soda lime is filled up in two chambers.
It further include an anesthesia induction as a preferred embodiment of the circulating inhalation anaesthesia apparatus of the present invention
Box, the anesthesia induction box are equipped with air inlet and air outlet, and air inlet is by pipeline and is arranged in big air storage bag and second gas
The triple valve on pipeline between flowmeter is connected, and gas outlet passes through pipeline and outlet and recyclegas mistake that mask is arranged in
The triple valve between the air inlet of box on pipeline is filtered to be connected.The anesthesia induction box is preferably a closed acrylic box, at this
The bottom of anesthesia induction box is paved with soda lime.
As a preferred embodiment of the circulating inhalation anaesthesia apparatus of the present invention, the mask is umbellate form face
Cover is equipped with the centre bore sealed with elastic material at the center of the bottom surface of umbellate form mask, and the centre bore is preferably cone；
It is further preferred that the umbellate form mask is that the bottom surface made of the main body and rubber of cone forms, at the middle part of bottom surface
Equipped with the centre bore identical by flexible deformation and the upper lower jaw of rat；Entrance and exit is equipped in the main body of the cone,
The top of mask is equipped with a small air storage bag.
The mask of the circulating inhalation anaesthesia apparatus of the present invention is a umbrella breathing mask, and centre bore is sealed using elastic material
Mouthful, for fixing the upper lower jaw of rat.Since centre bore is flexible, not only tensity is fine, can be firmly by the mouth and nose of rat
It is fixed in mask, not only can guarantee airtightness, but also not will lead to animal asphyxia.The outlet of mask is connected to recycling jar, rat
The gas not absorbed can absorb carbon dioxide and water by recycling can, leave isoflurane and oxygen and new anesthetic gases converge
It closes, rat is allowed to re-use.Achieve the effect that economize on resources and safety.
As a preferred embodiment of the circulating inhalation anaesthesia apparatus of the present invention, in the waste gas absorption tank
Entrance is equipped with digital pressure gauge；Active carbon is provided in the waste gas absorption tank.
The circulating inhalation anaesthesia apparatus device of the present invention mainly consists of three parts, i.e. dosed portions, inducing moiety and face
Cover portion point.Inducing moiety is a closed container, has inlet and outlet to be connected with dosed portions respectively, and visor portion is then assembled with threeway,
End connects a umbrella respirator, and rubber sealing is stayed a duck eye to be used to put animal head, since rubber is flexible, both be can guarantee
It is closed, and will not animal asphyxia.The inlet and outlet access of visor portion is connected with dosed portions respectively.Dosed portions are waved by anesthetic
Send out tank and gas flowmeter composition.When administration, oxygen tank is connected, oxygen will be mixed with the oxygen of anesthetic by anesthetic Volatile anesthetic
It is transported in the induction box of inducing moiety, the gas that animal breathes out in induction box is by gas returnable bottle absorbing carbon dioxide
Afterwards, residual gas is again introduced into administration access after mixing with fresh oxygen and anesthetic, moves in circles.Visor portion and induction
What part was walked is two different accesses, and when use can block the anesthesia access of inducing moiety to connect visor portion, otherwise
The anesthesia access that inducing moiety blocks visor portion can be connected.It is logical for monitoring that gas gauge is additionally provided in whole system
Air pressure in road convenient for regulating and controlling at any time, while having the opening and closing of flowmeter control access in each branch, it is ensured that each anesthesia
The anesthesia amount in channel.Device is additionally provided with waste gas absorption tank, avoids exhaust gas from being discharged into air and pollute and endangers laboratory technician's health.
In order to verify the anaesthetic effect of anesthesia outfit of the invention, the present invention using the device to the anaesthetic effect of rat into
Row operation verifying.Rat anesthesia is subjected to routine operation (laparotomy and gastrotomia) using the present apparatus, anesthesia is recorded in art
The time in each stage, and with the continuous dynamic monitoring rats breathing (RR) of physiological monitor, heart rate (HR), blood oxygen (SpO2), receive
Contracting pressure (SBP), mean arterial pressure (MAP) and body temperature (T), while calm rat, analgesia and flesh pine effect are observed, to evaluate anesthesia
The safety and availability of device.Observation as a result, it has been found that, time induce with anesthesia outfit of the present invention to rat anesthesia is 2.20
± 0.45min, reaching is 2.12 ± 0.36min the time required to surgical anesthesia, anesthesia maintenance and recovery time be respectively 45.18 ±
0.12min and 2.40 ± 0.55, anesthesia total time are 51.40 ± 0.24min.Rat calmness, analgesia, muscular relaxation effect are good in art
It is good, HR, SpO when performing the operation the 10th, 20,30,45min2, the equal held stationary of RR, T, SBP, MAP, every physical signs is each
Time point, all there was no significant difference (p > 0.05).Experiment results proved inhalation anaesthesia apparatus of the present invention is true to rat anesthesia effect
Real, safely controllable, anesthesia induction and recovery time are very fast, can fully meet the requirement performed the operation to anesthesia.
The circulating inhalation anaesthesia apparatus of the present invention mainly have following several respects the utility model has the advantages that
(1) Conventional masks are replaced with elastic rubber mask in this anesthesia outfit, solves mask opening poor air-tightness
Problem；The mask be a umbrella breathing mask, center band rubber hole, by rubber mouth fixing sleeve rat positions of maxilla and mandible,
Both it ensure that the air-tightness of mask was good, and also prevented mask tension and hinder rats breathing.
(2) mask of this anesthesia outfit be a umbrella breathing mask, center band rubber hole, top be also mounted one it is stingy
Capsule can buffer the gas pressure into mask while also act as the effect of pressure instruction, can effectively avoid positive pressure in mask
It is excessive and avoid influencing rats breathing or lungs to be caused to damage.
(3) this anesthesia outfit forms anesthetic gases by recyclegas filter cartridge, minipump and waste gas absorption tank
Cycling element can utilize the unabsorbed anesthetic gases of rat and circulating oxygen.
Detailed description of the invention
Fig. 1 is the overall structure diagram of the embodiment of the present invention；
Fig. 2 is the axial sectional view of mask of the invention；
The working principle explanatory diagram of Fig. 3 mask of the present invention.
Description of symbols: 1. oxygen tanks, 2. oxygen pressure reducers, 3. first gas flowmeters, 4. anesthetic gases Volatile anesthetics,
5. the triple valve between big air storage bag and first gas flowmeter, 6. anesthesia induction boxes, 7., which are located at mask, exports and recycles
Triple valve between gas filtration box, 8. recyclegas filter cartridges, 81. partitions, 82. connecting tubes, 9. minipumps, 10. is big
Air storage bag, 11. second gas flowmeters, 12. masks, the cone body of 121. masks, the bottom surface of 122. masks, 123. centers
Hole, the air inlet of 124. masks, the gas outlet of 125. masks, 13. small air storage bags, 14. waste gas absorption tanks, 15. digital pressure gauges.
Specific embodiment
Further describe the present invention below in conjunction with attached drawing, the advantages and features of the present invention will be with description and more clear
Chu.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.Those skilled in the art should
Understand, details and form of the invention can be modified or be replaced without departing from the spirit and scope of the invention,
But these modifications and replacement are fallen within the protection scope of the present invention.
Referring to Fig. 1, a kind of circulating inhalation anaesthesia apparatus of the present invention, including oxygen tank 1, first gas flowmeter 3, anesthesia
Gaseous volatilization tank 4, anesthesia induction box 6, recyclegas filter cartridge 8, minipump 9, big air storage bag 10, second gas flowmeter
11, mask 12, small air storage bag 13 and waste gas absorption tank 14；Wherein, the outlet of oxygen tank 1 passes through oxygen pressure reducer 2 and pipeline
It is connect with the entrance of first gas flowmeter 3, the outlet of first gas flowmeter 3 passes through pipeline and anesthetic gases Volatile anesthetic 4
Entrance connection, there are three circuits for the outlet connection of the anesthetic gases Volatile anesthetic 4: the first via is connect with the outlet of minipump 9,
The entrance of the minipump 9 connect with a recyclegas filter cartridge 8 after respectively with the outlet of mask 12, anesthesia induction box 6
The connection of the entrance of outlet and waste gas absorption tank 14；Second tunnel is connect by a triple valve 5 with the entrance of anesthesia induction box 6,
The outlet of the anesthesia induction box 6 is connect by another triple valve 7 with the entrance of the outlet of mask 12 and recyclegas filter cartridge 8；
Third road is connect by second gas flowmeter 11 and pipeline with the entrance of mask 12, the outlet of mask 12 with waste gas absorption
Tank 14 connects.Big air storage bag 10 is housed on the outlet conduit of the minipump 9, small air storage bag is housed on the mask 12
13.Digital pressure gauge 15 is housed in the entrance of the waste gas absorption tank 14.It is filled in the waste gas absorption tank 14 active
Charcoal.
This anesthesia outfit passes through setting minipump 9, recyclegas filter cartridge 8 and waste gas absorption tank 14, these dresses
It sets and forms an anesthetic gases circulator with anesthetic gases Volatile anesthetic 4 and mask 12, it can be by the unabsorbed anesthesia of rat
Gas and oxygen recycles.Recyclegas filtering can be given by installing minipump in the outlet of recyclegas filter cartridge
The certain draft of box 8 makes gas keep one-way circulation；Do not enter the recyclegas of recyclegas filter cartridge 8, then by pipeline into
Enter waste gas absorption tank 14 by activated carbon adsorption therein.
In anesthesia maintenance, dosed portions first gas flowmeter 3 is adjusted, oxygen input flow rate 0.15L/min is made；Together
When to adjust the gas flow of the second gas flowmeter 11 close to 12 part of mask be 0.2L/min, and isoflurane concentration is adjusted
It is connected to 2.5%, then by a digital pressure gauge with waste gas absorption pipe end, by adjusting 9 flow velocity of minipump, inhales exhaust gas
Then waste gas absorption pipe is connected waste gas absorption tank 14 again, can make not sucked by rat in this way by the pressure of closed tube end close to 0
Anesthetic gases re-use, thus reduce exhaust gas discharge and anesthetic gases loss, improve the utilization rate of anesthetic gases.?
It is found in operation verifying, carry out maintenance anesthesia to rat in this way, rats breathing is in good condition, and breathing is steady, visually
Mucous membrane color is normal, and blood oxygen can maintain 98% or more.
As a kind of preferred embodiment of the present invention, the recyclegas filter cartridge 8 uses acrylic box, in the Asia
Two chambers are divided into using partition between the both ends of gram force box, are connected between two two chambers with connecting tube, in two chambers
Soda lime is filled up in interior.The cascaded structure for forming two chambers, enhances filter effect.
As a kind of preferred embodiment of the present invention, the anesthesia induction box is a closed acrylic box, in the fiber crops
The bottom of liquor-saturated induction box is paved with soda lime.
Referring to figs. 2 and 3, the mask 12 bottom surface 122 made of the main body 121 and rubber of cone forms,
The middle part of bottom surface 122 is equipped with centre bore 123 that can be identical by flexible deformation and the upper lower jaw of rat；In the main body of the cone
121 are equipped with entrance 124 and outlet 125, and are connect using individual passage with the small air storage bag 13.The main body of cone
121 can adopt made of plastic, and the entirety of mask 12 can also be used rubber and be made.Since the centre bore 123 of bottom surface 122 is circular cone
Shape (or edge very thin other shapes), edge can in the case where applying smaller pressure flexible deformation, so using
When, after the oral area A of the rat of test is inserted into centre bore 123, the edge of centre bore 123 is bent upwards deformation (referring to figure
3) it coincide, and with the upper lower jaw of rat and is adjacent to, the anesthetic gases in mask 12 will not leak outside from centre bore 123 substantially.Due in
Heart hole 123 is flexible, and not only tensity is fine, and firmly the mouth and nose of rat can be fixed in mask 12, both can guarantee close
Closing property, and not will lead to animal asphyxia.The outlet of mask 12 is connected to recyclegas filter cartridge 8 and waste gas absorption tank 14, greatly
The gas that mouse does not absorb can absorb carbon dioxide and water by recyclegas filter cartridge 8, leave isoflurane and oxygen and new
Anesthetic gases converge, allow rat to re-use, achieved the effect that economize on resources and safety.
The working principle of the invention is: the anesthesia outfit is divided into anesthesia induction circulation path and anesthesia maintenance circulation path two
Part is respectively described below:
1, anesthesia induction circulation path:
Anesthesia induction circulation path are as follows: the output end of oxygen tank 1 is connected by the input terminal of pipeline and first gas flowmeter 3
It connects, the output end of first gas flowmeter 3 is connect by conduit with the input terminal of anesthetic gases Volatile anesthetic 4, anesthetic gases volatilization
The output end of tank 4 and the output end of micro vacuum pump 9 converge, and anesthetic gases pass through three after big air storage bag 10 is stored and is buffered
The control of port valve 5 enters anesthesia induction box 6, and oxygen and anesthetic are after rat sucks, the CO of exhalation2Pass through threeway with residual gas
The control of valve 7 enters recyclegas filter cartridge 8 for CO2Filtering, remaining oxygen and anesthetic gases under the suction of minipump 9,
Anesthesia induction access is reentered to be recycled.The mixing of recyclegas filter cartridge 8 is drawn into without minipump 9
Gas is then absorbed by waste gas absorption tank 14.In entrance (end M) the connection connection digital pressure gauge 15 of waste gas absorption tank 14, pass through tune
The suction flow for saving minipump 9, so that the output of the end M mixed gas, close to 0kPa, this operation can be reduced as far as possible
The discharge of mixed gas improves its utilization rate.
2, anesthesia maintenance circulation path: the output end of oxygen tank 1 is connected by the input terminal of pipeline and first gas flowmeter 3
It connects, the output end of first gas flowmeter 3 is connect by conduit with the input terminal of anesthetic gases Volatile anesthetic 4, anesthetic gases volatilization
The output end of tank 4 and the output end of micro vacuum pump 9 converge, and after big air storage bag 10 is stored and is buffered, are controlled by triple valve 5
Into second gas flowmeter 11, oxygen and anesthetic in mask 12 after rat sucks, the CO of exhalation2It is logical with residual gas
It crosses the control of triple valve 7 and enters recyclegas filter cartridge 8 for CO2The pumping of filtering, remaining oxygen and anesthetic gases in minipump 9
Under suction, reenters anesthesia maintenance access and recycled.Small air storage bag 13 on mask 12 plays pressure buffer and instruction is made
With.
Test example 1 carries out general anaesthesia operation verifying to rat using anesthesia outfit of the present invention
1 materials and methods
1.1 material
1.1.1 experimental animal
SD rat 10, half male and half female, 258 ± 23g of weight is purchased from dimension experimental animal Co., Ltd of tonneau China, same
Under the conditions of raising 15d tested.
1.1.2 main consumptive material
Gaseous volatilization tank (hundred million Anji medical science and technology Co., Ltd of Beijing), waste gas absorption tank (Hefei gold brain people's photoelectric instrument
Co., Ltd), gas flowmeter (the bicyclic finite instrument company in Changzhou), minipump (the limited public affairs of Shanghai card Gadamer science and technology
Department), (Beijing Yong Shengkang acrylic product has for intelligent digital pressure gauge (Hangzhou meter Ke Sensotech Ltd.), acrylic board
Limit company).
1.1.3 drug and instrument
Isoflurane (Hebei Jiupai Pharmacy Co., Ltd.), medical soda lime (Shanghai receive the dry chemical reagent work of final roasting), medical oxygen
(Softtron, BP-2010, the soft grand biotechnology in Beijing are public for (Beijing North Yang Lilai gas Co., Ltd), physical signs monitor
Department).
1.2 operation verification methods
1.2.1 rat laparotomy detects stomach function regulating cutting operation
Test is groped it is found that using apparatus of the present invention in oxygen flow 0.15L/min, isoflurane is dense by anesthesia early period
Degree can generate good anaesthetic effect to rat when being 2.5%.This test selects 10 SD rats to carry out out abdomen with this condition
Detect stomach function regulating cutting operation.Rat is lain on the back Baoding, rat abdomen shaving is sterilized, drape isolation, with scalpel along ventrimeson
Pleat cuts skin, separation subcutaneous tissue, muscle and peritonaeum, exposure abdominal cavity.Each internal organs appearance in abdominal cavity is observed, is determined whether different
Often；Rat abdominal cavity is detected with finger, while pulling each internal organs or structure observation rat pain reaction.Abdominal exploration is complete
Finish, does draught line at the less place's stomach wall cut-off lines both ends of stomach wall blood vessel, sharp property cuts stomach wall, rinses notch after detecting gastral cavity, double
It is also received abdominal cavity by layer suture stomach wall.Last conventional closure incision of abdominal wall.
1.2.2 anaesthetic effect is evaluated
(1) sedation effect is evaluated
Every the calmness of 10min record rat, analgesia and flesh pine effect during laparotomy stomach function regulating cutting operation, to comment
The availability of valence anesthesia outfit.Sedation effect need to well meet in art to external sound without significant reaction, and operation is gone on smoothly.
(2) analgesic effect is evaluated
Analgesic effect need to well meet following condition: cutting skin without pain reaction；Blunt separation subcutaneous tissue without
Pain reaction；Passivity or the separation muscle without pain reaction of sharp property；Pull internal organs and the reaction of mesenterium without pain；Hollow organ is cut
It cuts, detect, suturing without pain reaction；Clamping, cutting, the reaction of peritoneal suture without pain；The reaction of skin suture without pain；It is postoperative dynamic
Without obvious pain present after object revival.
(3) muscular relaxation effect assessment
Flesh pine works well when need to meet cutting skin in art and separate muscle, and muscle is without tensile force；It cuts in after peritonaeum
Dirty holding origin-location, no internal organ gush out phenomenon；When pulling internal organ, internal organ retraction force very little.
1.2.3 in art physical signs monitoring
Rat items physical signs is monitored with physiological monitor during laparotomy stomach function regulating cutting operation, every
10min records rats breathing (RR), heart rate (HR), blood oxygen (SpO2), systolic pressure (SBP), mean arterial pressure (MAP) and body temperature
(T), to evaluate the safety of anesthesia outfit.
12.4 statistical analysis
Data statistic analysis is carried out with SPSS17.0 statistical software, significance difference analysis uses one-way analysis of variance
(one-way ANOVA), different time point data relatively adopt LSD inspection, and data are with mean ± standard deviationIt indicates.
2 test results
2.1 rat operation anesthesia durations statistics
Good anaesthetic effect can be generated to rat under 2.5% isoflurane concentration using the present apparatus, in laparotomy and
In stomach cutting operation verification process, rat induced anesthesia, the time for reaching surgical anesthesia are very fast, perform the operation after continuing 45min, rat
Can from anesthesia rapid recovery (being shown in Table 1).The anesthesia outfit has anesthesia maintenance time controllable precise, and induction and recovery time are fast
Equal clear superiorities.
The statistics of 1. laparotomy of table and gastrotomia to the rat anesthesia time
Rat calmness, analgesia and flesh pine effect in 2.2 arts
As shown in Table 2, using this anesthesia outfit (isoflurane concentration 2.5%) to progress laparotomy stomach function regulating after rat anesthesia
Cutting operation, rat is calm in art, muscular relaxation effect is good, and without pain reaction can fully meet the requirement performed the operation to anesthesia and (be shown in Table
2)。
Calm in 2. laparotomy of table and gastrotomia, analgesia and flesh pine effect observation (n=10)
The variation of rat physical signs in 2.3 arts
Under 2.5% isoflurane concentration, rat is anaesthetized using the present apparatus, row laparotomy stomach function regulating cutting operation is tested
It demonstrate,proves, rat items physical signs is monitored in surgical procedure, the results showed that rat HR, SpO2, RR, T, SBP, MAP be in operation the
10, obviously do not fluctuated when 20,30,45min, and each single item physical signs all there was no significant difference in various time points (p >
0.05), this illustrates to carry out surgical operation after the anesthesia outfit anaesthetizes rat, and Study on Physiologic in art can be kept steady
(being shown in Table 3).
3. laparotomy of table and gastrotomia to rat physical signs influence (N=10)
In anesthesia maintenance, dosed portions flowmeter is adjusted, oxygen input flow rate 0.15L/min is made；Face is adjusted simultaneously
Cover portion shunt meter gas flow be 0.2L/min, and by isoflurane concentration adjust to 2.5%, then by a digital pressure gauge with
Waste gas absorption pipe end is connected, and by adjusting micro vacuum flow rate pump, makes the pressure of waste gas absorption pipe end close to 0, then
Waste gas absorption pipe is connected into waste gas absorption tank again, the anesthetic gases not sucked by rat can in this way re-used, to reduce
Exhaust gas discharge and anesthetic gases loss, improve the utilization rate of anesthetic gases.It is found in operation verifying, using this side
Formula carries out maintenance anesthesia to rat, and rats breathing is in good condition, and breathing is steady, and Visual mucous membrane color is normal, and blood oxygen can maintain
98% or more.Compared with external similar anesthesia method, the physiological indexes such as body temperature, blood pressure, heart rate and blood oxygen of rat and
The recovery from anesthesia time is almost the same.
Claims (10)
1. a kind of circulating inhalation anaesthesia apparatus, including oxygen tank (1), first gas flowmeter (3), anesthetic gases Volatile anesthetic
(4), mask (12) and waste gas absorption tank (14)；Wherein, the outlet of oxygen tank (1) passes through oxygen pressure reducer (2) and pipeline and the
The entrance of one gas flowmeter (3) connects, and the outlet of first gas flowmeter (3) passes through pipeline and anesthetic gases Volatile anesthetic (4)
Entrance connection, the outlet of the anesthetic gases Volatile anesthetic (4) passes through second gas flowmeter (11) and pipeline and mask (12)
Entrance connection；The outlet of mask (12) is connect with waste gas absorption tank (14)；It is characterized in that, the anesthetic gases Volatile anesthetic (4)
Outlet and a minipump (9) gas outlet converge after successively enter again with second gas flowmeter (11) and mask (12)
Mouth connection；The air inlet of the minipump (9) is connected with the gas outlet of recyclegas filter cartridge (8) by pipeline, circulating air
The air inlet of body filter cartridge (8) is connect by pipeline with the outlet (125) of mask (12)；In the gas outlet of minipump (9)
Big air storage bag (10) are housed on pipeline between second gas flowmeter (11).
2. circulating inhalation anaesthesia apparatus according to claim 1, which is characterized in that be additionally provided with an anesthesia induction box
(6), which is equipped with air inlet and air outlet, and air inlet and setting are in big air storage bag (10) and second gas
Triple valve (5) on pipeline between flowmeter (11) is connected, gas outlet with outlet (125) in mask (12) is set and is followed
Triple valve (7) between the air inlet of ring gas filtration box (8) on pipeline is connected.
3. circulating inhalation anaesthesia apparatus according to claim 1 or 2, which is characterized in that the recyclegas filtering
Box (8) uses acrylic box, is divided into two chambers, two chambers using partition (81) between the both ends of the acrylic box (8)
It is connected between room with connecting tube (82), soda lime is filled up in two chambers.
4. circulating inhalation anaesthesia apparatus according to claim 2, which is characterized in that the anesthesia induction box (6) is
One closed acrylic box are paved with soda lime in the bottom of the anesthesia induction box (6).
5. circulating inhalation anaesthesia apparatus according to claim 1, which is characterized in that the mask (12) is umbellate form face
Cover is equipped with the centre bore (123) sealed with elastic material at the center of the bottom surface of umbellate form mask.
6. circulating inhalation anaesthesia apparatus according to claim 1 or 5, which is characterized in that the mask (12) be by
The umbellate form mask of bottom surface (122) composition made of the main body (121) and rubber of cone is equipped with logical at the middle part of bottom surface (122)
Cross flexible deformation and the rat above identical centre bore (123) of lower jaw；Entrance (124) are equipped in the main body (121) of the cone
With outlet (125).
7. circulating inhalation anaesthesia apparatus according to claim 6, which is characterized in that the cone of the mask (12)
Body top is equipped with one small air storage bag (13).
8. circulating inhalation anaesthesia apparatus according to claim 6, which is characterized in that the centre bore (123) is circle
Taper.
9. circulating inhalation anaesthesia apparatus according to claim 1, which is characterized in that in the waste gas absorption tank (14)
Entrance be equipped with digital pressure gauge (15).
10. circulating inhalation anaesthesia apparatus according to claim 1, which is characterized in that in the waste gas absorption tank
(14) it is provided with active carbon.
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| CN2018111051166 | 2018-09-21 | ||
| CN201811105116 | 2018-09-21 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111759526A (en) * | 2020-07-16 | 2020-10-13 | 河北医科大学 | Suction-type anesthesia experiment platform device |
| GB2611097A (en) * | 2021-09-28 | 2023-03-29 | Vet Tech Solutions Ltd | Gas delivery device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586534A (en) * | 2014-04-16 | 2015-05-06 | 复旦大学 | Simple small animal inhalation anesthesia machine |
| CN205849947U (en) * | 2016-06-19 | 2017-01-04 | 付鹏 | Anesthesia aeration cycle system |
| CN210408672U (en) * | 2018-09-21 | 2020-04-28 | 北京农学院 | Circulating type inhalation anesthesia device |
-
2018
- 2018-09-27 CN CN201811133523.8A patent/CN108938141B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586534A (en) * | 2014-04-16 | 2015-05-06 | 复旦大学 | Simple small animal inhalation anesthesia machine |
| CN205849947U (en) * | 2016-06-19 | 2017-01-04 | 付鹏 | Anesthesia aeration cycle system |
| CN210408672U (en) * | 2018-09-21 | 2020-04-28 | 北京农学院 | Circulating type inhalation anesthesia device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111759526A (en) * | 2020-07-16 | 2020-10-13 | 河北医科大学 | Suction-type anesthesia experiment platform device |
| GB2611097A (en) * | 2021-09-28 | 2023-03-29 | Vet Tech Solutions Ltd | Gas delivery device |
| GB2611097B (en) * | 2021-09-28 | 2023-11-01 | Vet Tech Solutions Ltd | Gas delivery device |
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