CN108936626A - For the high fat diet composition and preparation method thereof of tumor patients - Google Patents
For the high fat diet composition and preparation method thereof of tumor patients Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to a kind of high fat diet compositions and preparation method thereof for tumor patients, the composition raw materials according to the mass fraction, include: 1 part of fats, 0.1~0.8 part of protein, 0.2~0.4 part of dietary fiber, 0.05~0.2 part of full silkworm freeze-dried powder；The full silkworm freeze-dried powder is the freeze-dried powder that silkworm adult obtains after superfreeze crushes.Preparation method includes raw material cleaning, superfreeze, spray drying, beats 5 powder mixing, disinfection, encapsulation steps.High fat diet composition of the invention, dietary fiber and full silkworm freeze-dried powder must be added by specifying, specify the ratio of dietary fiber and full silkworm freeze-dried powder；Good protein can be supplemented by full silkworm freeze-dried powder, it improves the selective hungry tumour cell of immunity, high fat diet, generate the critical path in rationality ketonemia adjusting tumor development, antitumor action body is generated, it is edible directly to give various cancer patients as dietotherapy substance.
Description
Technical field
It is specifically a kind of for the high fat diet composition of tumor patients and its preparation the present invention relates to high fat diet
Method.
Background technique
The study found that full silkworm freeze-dried powder immunological regulation, it is antitumor, anti-inflammatory, anti-radiation, reduce blood glucose, reduce cholesterol,
Blood pressure lowering and antithrombotic etc. are many-sided to have good pharmacological activity.It is attracted wide public concern in medical domain, becomes current
The emphasis of research and development.
High fat diet (ketogenic-diet, abbreviation KD) is a kind of high-fat, low-carb Formula Diets, is made
Body generates ketone body metabolism, and it is horizontal to improve beta-hydroxybutyric acid in blood.Ketoboidies becomes main energy source when high fat diet, relatively
For glycometabolism, ketoboidies enter tricarboxylic acid cycle metabolism generate energy velocity it is very fast, consume isodose oxygen when, ketoboidies generate
Energy it is more.High fat diet reduces blood glucose by limiting absorption to carbohydrate, selectivity starvation tumour cell and
Hinder its growth.It is high-fat contained in its ingredient can be with physiology ketonemia, metabolite then adjustable tumour
Critical path in occurrence and development, plays antitumor action.Many scholars confirm high fat diet in various tumor models such as brain
Antitumor action in malignant tumour, prostate cancer, gastric cancer, lung cancer and head and neck neoplasm.
Although high fat diet shows certain activity in the treatment of many tumours, since its effect is not strong enough,
Cause clinically application and popularizations it is limited.The application number of packages amount of high fat diet involved in Chinese patent database is also less.So far
Until, it there is no and full silkworm freeze-dried powder and high fat diet combine the document report used.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of high fat diet composition for tumor patients and its
Full silkworm freeze-dried powder and high fat diet are combined into composition by preparation method, and silkworm powder is hypoglycemic, anti-tumour phological activity playing
While, the antitumor action of collaboration enhancing high fat diet provides a kind of drink for having both nutrition He treatment function for tumor patient
Food, improves the prognosis of tumor patient.
The technical solution used to solve the technical problems of the present invention is that:
A kind of high fat diet composition for tumor patients, according to the mass fraction, raw materials include: fats 1
Part, 0. 1~0.8 part of protein, 0.2~0.4 part of dietary fiber, 0.05~0.2 part of full silkworm freeze-dried powder；The full silkworm freeze-dried powder
It is the freeze-dried powder that silkworm adult obtains after superfreeze crushes.
Further, the silkworm adult is the adult in silkworm third day after five husking growths.
Further, the full silkworm freeze-dried powder contains: protein 56.76-62.10%, fiber 4.59-6.62%, moisture
3.92-4.77%, fatty 9.27-13.38%, ashes 6.52-9.14%, calcium 0.44%, phosphorus 0.86%, sodium 0.04-0.06%, magnesium
0.25-0.38% and a variety of amino acid, polysaccharide, flavonoids.
Further, the fat is one or more of edible vegetable oil, fat meat class and unsaturated fatty acid；The egg
White matter is one or more of livestock meat, the flesh of fish, peeled shrimp, egg and bean product；The dietary fiber sources include that mulberry leaf mention
Take one or more of fiber, vegetables, five cereals.
The preparation method of the above-mentioned high fat diet composition for tumor patients, including the following steps:
(1) silkworm body freezes
By silkworm body after pure water cleans 2-3 times, cryogenic freezing, cooling time 30-180min are carried out by liquid nitrogen；
(2) raw material cleans
Fat, protein, dietary fiber are washed 2~3 times with clear water, remove impurity；
(3) it dries
The raw material stoving that will be cleaned in drying equipment, process conditions are 24 °C~120 °C of temperature, drying time 10~
180 min, are cooled to room temperature later；
(4) it mixes
By prescription quality ratio, by 1 part of fats, 0. 1~0.8 part of protein, 0.2~0.4 part of dietary fiber, full silkworm freeze-dried powder
0.05~0.2 part and various seasonings, mix in mixing apparatus, stir evenly；
(5) it sterilizes
Mixture is used into pasteurization sterilization, temperature control at 125 °C~135 °C, time control 15~
45min；
(6) it encapsulates
Mixture after disinfection is cooled to room temperature, is vacuum-packed with conventional method to get the life ketone containing full silkworm freeze-dried powder is arrived
Diet.
The present invention by adopting the above technical scheme, compared with prior art, beneficial effect is:
Full silkworm freeze-dried powder enhances high fat diet in conjunction with high fat diet while obviously playing full silkworm freeze-dried powder physiological activity
Antitumor action.Thus obtained high fat diet composition therapeutic effect is remarkably reinforced, it can not only pass through high fat diet starvation
Tumour cell plays and hinders its growth, meanwhile, immunity of organisms is also enhanced by the full silkworm freeze-dried powder in formula, inhibits tumour
Cell growth, plays the role of multiple adjuvant therapy of tumors.So that the composition can be used as common high fat diet
It in the adjuvant treatment of the diseases such as tumour, and produces beyond expected immunological enhancement, hence it is evident that be better than single high fat diet
Treatment.
By animal experiment and patient's dietotherapy clinical test, demonstrate high fat diet composition of the invention has applicant
The effect of antitumor adjuvant treatment, it was confirmed that the present invention can enhance body immunity, inhibit the effect of tumor proliferation growth,
Generate super expected synergistic antitumor activity.It is only explained below in experiment and dietotherapy case with portion forms:
Experiment 1: Transplanted tumor model is established with nude mice by subcutaneous MCF-7 Breast Cancer Cell injection method, by model after modelling success
Mouse is divided into control group, full silkworm freeze-dried powder high fat diet intervention group and conventional high fat diet intervention group, and every group experimental animal 8.Often
It is quantity-unlimiting to give high fat diet, observes each group tumor size after intervening processing 28d and calculates the knurl weight of every group of tumour, inhibiting rate
And apoptotic index result of study: compared with the control group, full silkworm freeze-dried powder high fat diet intervention group and conventional high fat diet intervention group
Tumor weight reduces, and tumour inhibiting rate is respectively 28.29% and 21.68%；Apoptotic index is increased than control group, the raw ketone drink of full silkworm freeze-dried powder
Eating intervention group and conventional high fat diet intervention group is respectively 12.18 ± 1.85% and 9.11 ± 1.28% VS 6.82 ± 1.22%.
Inhibiting effect of the 1. two groups of high fat diets of table to growth of transplanted human
| Group | Tumor quality g | Tumour inhibiting rate % | Apoptotic index % |
| Control group | 4.18±0.73 | 6.82±1.22 | |
| Full silkworm freeze-dried powder high fat diet group | 2.84±0.68▲ | 28.29 | 12.18±1.85▲ |
| Conventional high fat diet group | 3.68±0.78▲△ | 21.68△ | 9.11±1.28▲△ |
Note:▲ P< 0.05 vs control group,△ P< 0.05 vs routine high fat diet group.
Based on above-mentioned experiment, high fat diet composition provided by the invention directly gives cancer patient as dietotherapy substance
It is edible, and cooperate other treatment means, reach therapeutic purposes.
It is clinical dietotherapy test case below:
Dietotherapy example 1, Mr. Li, people from Zunhua, male, the age 68 years old, patients with gastric cancer.It is multiple that postoperative metastasis is confirmed as in January, 2017 diagnosis
Hair, and have transfer sign, it is contemplated that patient is old and frail, and patient voluntarily abandons chemotherapy.Start to eat life of the invention after going home
Ketone diet, when starting dietotherapy, patient mental's state is general, and appetite is fine, weight loss.When dietotherapy, by 80kcal/kg weight into
Food, 3 times in the morning, afternoon and evening, adheres to dietotherapy so far, patient mental is clearly better at present, and weight gain is obvious.Period checks, finds lesion
Has the tendency that diminution, tumor marker is without the trend of raising, (3) 3+, CD4+, (3) 8+ cell and IgG, IgA and IgM in blood samples of patients
Protein level increase it is obvious, patients ' life quality be improved significantly, patient is to this patent high fat diet good results.
Dietotherapy example 2, thanks certain, people from Tangshan City, female, and the age 66 years old.In April, 2017 because Mammary cancer multi viscera shifts, examines
Break as advanced breast cancer；Hepatic and renal function, blood routine, normal ECG are looked into when being admitted to hospital.Using taxol+Xeloda side's chemotherapy, totally 6
Secondary, at first 10 days of second of chemotherapy, patient's symptoms of emesis was gradually aggravated, and patient is same during second of chemotherapy to be started to eat this
The high fat diet of invention, rear symptoms of emesis fade away, and no pantothenic acid phenomenon and have no obvious myelosuppression, and the course for the treatment of terminates
Afterwards, inspection result shows Liver metastases and lungs metastatic tumor reduces 30%, is immunized for tri- kinds of CD3+T, T4/T8 and NK in blood samples of patients
The quantity of cell significantly improves, and general body state is good, lays a good foundation for further treatment.
Specific embodiment
The present invention is described in detail with reference to embodiments.
This high fat diet composition for tumor patients that the present embodiment provides, according to the mass fraction, under
Raw material is stated to constitute: 1 part of fats, 0.5 part of protein, 0.3 part of dietary fiber, 0.1 part of full silkworm freeze-dried powder；Also containing suitable
Seasoning can be with or without having food additives, antioxidant, stabilization such as starch, salt, garlic, ginger and other flavouring
Agent.
Full silkworm freeze-dried powder is the adult in silkworm third day after five husking growths, is obtained after superfreeze crushes
Freeze-dried powder.Silkworm third day after five huskings growth, starts the stage that spinning becomes cocoon, this stage silkworm body obesity is delicate,
Rich fibroin rich in, the silkworm of this period can especially eat mulberry leaf, be rich in the body of silkworm in the body of its aobvious transparence
There are many active ingredient substance, including taking in the enrichment in vivo of the active constituent of mulberry leaf or itself producing in vivo.Mainly have
Protein, fiber, fat, various microelements, flavone compound, a variety of amino acid, sbombycin (insulin-like growth factor IGF-
And antineoplastic component 1-DNJ etc. 1).
The full silkworm freeze-dried powder of the present embodiment contains: protein 56.76-62.10%, fiber 4.59-6.62%, moisture 3.92-
4.77%, fatty 9.27-13.38%, ashes 6.52-9.14%, calcium 0.44%, phosphorus 0.86%, sodium 0.04-0.06%, magnesium 0.25-
0.38% and a variety of amino acid, polysaccharide, flavonoids.
Fat in the present embodiment is edible vegetable oil, and protein is the flesh of fish, peeled shrimp, egg, and dietary fiber is that mulberry leaf mention
Take fiber, vegetables.
The preparation method of the high fat diet composition for tumor patients of the present embodiment, follows these steps to carry out:
(1) by silkworm body after pure water cleans 2-3 times, cryogenic freezing, cooling time 30-180min are carried out by liquid nitrogen；
(2) fat, protein, dietary fiber are washed 2~3 times with clear water, removes impurity；
(3) raw material stoving that will be cleaned in drying equipment, process conditions are 24 °C~120 °C of temperature, drying time 10
~180 min, are cooled to room temperature later；
(4) prescription quality ratio is pressed, by 1 part of fats, 0. 1~0.8 part of protein, 0.2~0.4 part of dietary fiber, full silkworm are frozen
0.05~0.2 part of dry powder and various seasonings, mix in mixing apparatus, stir evenly；
(5) mixture is used into pasteurization sterilization, temperature control at 125 °C~135 °C, time control 15~
45min；
(6) mixture after disinfection is cooled to room temperature, is vacuum-packed with conventional method to get the life containing full silkworm freeze-dried powder is arrived
Ketone diet.
The foregoing is merely the practicable embodiment of the present invention, not thereby limiting the scope of the invention,
It is all to use equivalence changes made by present specification, it is intended to be included within the scope of the present invention.
Claims (5)
1. a kind of high fat diet composition for tumor patients, it is characterised in that: according to the mass fraction, raw materials
Include: 1 part of fats, 0. 1~0.8 part of protein, 0.2~0.4 part of dietary fiber, 0.05~0.2 part of full silkworm freeze-dried powder；
The full silkworm freeze-dried powder is the freeze-dried powder that silkworm adult obtains after superfreeze crushes.
2. being directed to the high fat diet composition of tumor patients as described in claim 1, it is characterised in that: the silkworm adult
It is the adult in silkworm third day after five husking growths.
3. being directed to the high fat diet composition of tumor patients as described in claim 1, it is characterised in that: the full silkworm is frozen
Dry powder contains: protein 56.76-62.10%, fiber 4.59-6.62%, moisture 3.92-4.77%, fatty 9.27-13.38%, ash
Powder 6.52-9.14%, calcium 0.44%, phosphorus 0.86%, sodium 0.04-0.06%, magnesium 0.25-0.38% and a variety of amino acid, polysaccharide,
Flavonoids.
4. being directed to the high fat diet composition of tumor patients as described in claim 1, it is characterised in that: the fat is
One or more of edible vegetable oil, fat meat class and unsaturated fatty acid；The protein is livestock meat, the flesh of fish, peeled shrimp, egg
One or more of with bean product；The dietary fiber sources include that mulberry leaf extract one of fiber, vegetables, five cereals
Or it is several.
5. a kind of preparation side of the high fat diet composition according to any one of claims 1-4 for tumor patients
Method, characterized in that it comprises the following steps:
(1) silkworm body freezes
By silkworm body after pure water cleans 2-3 times, cryogenic freezing, cooling time 30-180min are carried out by liquid nitrogen；
(2) raw material cleans
Fat, protein, dietary fiber are washed 2~3 times with clear water, remove impurity；
(3) it dries
The raw material stoving that will be cleaned in drying equipment, process conditions are 24 °C~120 °C of temperature, drying time 10~
180 min, are cooled to room temperature later；
(4) it mixes
By prescription quality ratio, by 1 part of fats, 0. 1~0.8 part of protein, 0.2~0.4 part of dietary fiber, full silkworm freeze-dried powder
0.05~0.2 part and various seasonings, mix in mixing apparatus, stir evenly；
(5) it sterilizes
Mixture is used into pasteurization sterilization, temperature control at 125 °C~135 °C, time control 15~
45min；
(6) it encapsulates
Mixture after disinfection is cooled to room temperature, is vacuum-packed with conventional method to get the life ketone containing full silkworm freeze-dried powder is arrived
Diet.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110214850A (en) * | 2019-07-09 | 2019-09-10 | 唐山英盛生物科技有限公司 | Ice cream and preparation method thereof with function of polysaccharide |
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| CN1127637A (en) * | 1995-01-23 | 1996-07-31 | 农村振兴厅 | Agent for reducing blood suger containing powder of silkworm as effective ingredient and making of same |
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