CN108905249A - A kind of micro- package spray-dried instrument of large size - Google Patents
A kind of micro- package spray-dried instrument of large size Download PDFInfo
- Publication number
- CN108905249A CN108905249A CN201810869539.9A CN201810869539A CN108905249A CN 108905249 A CN108905249 A CN 108905249A CN 201810869539 A CN201810869539 A CN 201810869539A CN 108905249 A CN108905249 A CN 108905249A
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- Prior art keywords
- support plate
- micro
- outer barrel
- tube
- electric heating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/0011—Heating features
- B01D1/0017—Use of electrical or wave energy
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/0011—Heating features
- B01D1/0041—Use of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/30—Accessories for evaporators ; Constructional details thereof
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The invention discloses a kind of micro- package spray-dried instruments of large size, are related to technical field of medical treatment mechanical.The present invention includes substrate；One surface of substrate is respectively fixed with the first micro-injection pump, the second micro-injection pump, air pump and blower by the first support plate and the second support plate；Blower outlet air end is connected with electric heating tube by wind conveying pipe；Another surface of substrate is installed with cabinet；Cabinet top is installed with outer barrel；Outer barrel lower end is fixed with dry cavity；Inner cylinder is interspersed in outer barrel；Outer needle tubing is installed in inner cylinder；Inner needle tube is installed in outer needle tubing.The present invention is by matching setting using inner needle tube and outer needle tubing, composite conic is formed in inner needle tube and outer needle tubing lower end and generates compound jet, microlayer model is broken by means of the unstability in compound jet, and rapid draing is carried out to microlayer model using dry cavity, to realize package and the drying to medical fluid, market popularization value with higher.
Description
Technical field
The invention belongs to technical field of medical treatment mechanical, more particularly to a kind of micro- package spray-dried instrument of large size.
Background technique
Currently, the domestic dedicated dosage form of children's drug extremely lacks.The data provided according to the pharmaceutical sector chamber of commerce of the All-China Federation of Industry and Commerce are aobvious
Show, existing more than the 3500 a preparation variety of China, only 60 kinds of children special-purpose, ratio only accounts for 1.7%.Hospital can only " as one sees fit " with
Adult medication and dosage form replace children's drug.One statistics of State Food and Drug Administration shows the country 90%
Drug does not have children's dosage form.So-called children's medicine is often the decrement version of adult medicine.
For children's oral drugs, size, taste, the dose intensity etc. of dosage form are great challenges, and children swallow energy
The difference of power, taste preference, dose requirements etc. are but also oral drugs need different dosage forms.However, about 50% children
Drug does not have paediatric formats.The shelf-life of some liquid pediatric preparations under refrigerated conditions only has 3 months, shorter at room temperature,
Even over time, the activity of active drug ingredient can decline 45%.In addition, 50% or so 6-11 years old children gulp down
Pharyngea agent is difficult, and the bitterness sense of some clinic active drugs is difficult to cover by food or syrup, to be refused by child of tender age.
The technology that domestic market covers bitter taste use for children mainly adds corrigent method, fills drug
Microcapsules are coated tablet.Corrigent mainly includes sweetener, aromatic, effervescent agent and mucilage etc..Drug is covered in coating
Bitter taste art for coating is to wrap the clothing layer of appropriate materials on solid drugs surface, reaches preferable and covers bitter taste of drug and bad gas
The purpose of taste.In addition also useful micro-capsule or microballoon cover bitter taste of drug, micro-capsule, microballoon be in recent years medicinal application new process,
One protrusion of new technology represents.After medicament microcapsule, the bad smell of drug can be not only covered, and medicine can be improved
The stability of object, the effects of preventing drug from inactivating in stomach or reducing the irritation to stomach.
Currently, the drug particle size that existing package drying equipment wraps up out is bigger, for children taking,
It is difficult to swallow bulky grain drug, this is problem bigger existing for current wrapping device；Also, since microlayer model is set from package
Falling speed after oozing in standby is very fast, causes drug granule to be after drying easily broken because degree of drying is not thorough, sternly
The quality of drug is affected again.Therefore, it needs to study a kind of micro- package spray drying device, in order to solve the above problems.
Summary of the invention
The purpose of the present invention is to provide a kind of micro- package spray-dried instruments of large size, by utilizing inner needle tube and outer needle tubing phase
It is equipped with, forms composite conic in inner needle tube and outer needle tubing lower end and generates compound jet, by means of in the unstable of compound jet
Property and be broken into microlayer model, and rapid draing is carried out to microlayer model using dry cavity, thus realize to the package of medical fluid and
It is dry, it solves the problems, such as existing.
In order to solve the above technical problems, the present invention is achieved by the following technical solutions：
The present invention is a kind of micro- package spray-dried instrument of large size, including substrate；One surface of substrate fixed installing side by side
There are one first support plate and the second support plate；First support plate, one surface is fixed with one first micro-injection pump and one side by side
Second micro-injection pump；Second support plate, one surface is fixed with an air pump and a blower side by side；The blower outlet air end is logical
It crosses a wind conveying pipe and is connected with an electric heating tube；Fixation is installed with a third support plate and one the 4th side by side on another surface of substrate
Support plate；A cabinet is provided between the third support plate and the 4th support plate；The cabinet top is installed with an outer barrel；
The outer barrel upper end is through cabinet and third support plate and extends to above third support plate；The outer barrel upper end and electricity
Heating tube one end is connected；The outer barrel lower end is fixed to be installed with a dry cavity；The dry cavity lower end dress
Equipped with a collecting pipe；Fixation is interspersed with an inner cylinder in the outer barrel；The inner cylinder upper end and appendix one end phase
Connection；An outer needle tubing is installed in the inner cylinder；The outer needle tubing upper end is connected with the first perfusion tube one end；It is described
An inner needle tube is installed in outer needle tubing；The inner needle tube upper end is connected with the second perfusion tube one end；The outer barrel one
Side and be located at one surface of cabinet top fixation be installed with a tornadotron；The tornadotron is connected by a connecting tube with dry cavity
It is logical；The tornadotron upper end fixation is installed with an escape pipe；The tornadotron lower end fixation is installed with a micro mist receiving flask.
Further, it is connected between first support plate and the second support plate by support rod.
Further, second support plate lower surface and the 4th support plate lower surface are fixed with supporting leg side by side.
Further, the electric heating tube includes tube body and electric heating wire；The electric heating wire is circumferentially evenly arranged on
On inboard wall of tube body.
Further, the side wall of the cabinet is made of transparent high temperature resistant high-boron-silicon glass.
Further, the inner cylinder lower end and the dry tapered structure in cavity lower end.
Further, the outer barrel central axis and electric heating tube central axis are perpendicular；The outer barrel central axis
Line and electric heating tube central axis are not in the same plane.
The invention has the advantages that：
The present invention is by being arranged air pump prior to the first micro-injection pump and the second micro-injection pump work, and holding first is micro-
The liquid speed rate out for measuring syringe pump and the second micro-injection pump is identical, is utilized respectively the outside needle tubing injection package of the first micro-injection pump
Liquid and the second micro-injection pump utilize the generation air pressure at the lower port of inner cylinder when air pump work to inner needle tube liquid medicine injection
Difference is based on capillary flow phenomenon, using swiftly flowing gas-powered, with the mesh of certain flow outflow in outer needle tubing and inner needle tube
Mark fluid converges to form composite conic and generate compound jet, and projects from the lower port of inner cylinder, and compound jet is because unstable
Property be broken into microlayer model, to realize the package to medical fluid and taste masking, have that uniform particle diameter, encapsulation ratio are high, yield is high and suitable
With the advantages such as property is wide, and the drop of size in this way is very suitable to children taking, avoids that drug size is excessive to be difficult to swallow
Situation；By synchronous averaging blower and electric heating tube, hot wind enters dry cavity by outer barrel, passes through broken microlayer model
The rapid draing of overfire air, so that the active material in medical fluid still maintains its active ingredient constant after the drying, and microcapsule powder
Endization can effectively enhance the service efficiency and stability of drug；And it tornadotron is set extends hot wind and stop in dry cavity
The time is stayed, energy-efficient mesh has been reached.
Certainly, it implements any of the products of the present invention and does not necessarily require achieving all the advantages described above at the same time.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, will be described below to embodiment required
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for ability
For the those of ordinary skill of domain, without creative efforts, it can also be obtained according to these attached drawings other attached
Figure.
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is the structural front view of Fig. 1；
Fig. 3 is the structural side view of Fig. 1.
In attached drawing, parts list represented by the reference numerals are as follows：
1- substrate, the first micro-injection pump of 2-, the second micro-injection pump of 3-, 4- air pump, 5- blower, 6- cabinet, 7- outer cylinder
Body, 8- inner cylinder, the outer needle tubing of 9-, 10- tornadotron, 11- connecting tube, the first support plate of 101-, the second support plate of 102-, 103- the
Three support plates, the 4th support plate of 104-, 105- support rod, 106- supporting leg, the first perfusion tube of 201-, the second perfusion tube of 301-,
401- appendix, 501- wind conveying pipe, 502- electric heating tube, the dry cavity of 701-, 702- collecting pipe, 901- inner needle tube, 1001- go out
Tracheae, 1002- micro mist receiving flask.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts all other
Embodiment shall fall within the protection scope of the present invention.
It please refers to shown in Fig. 1-3, the present invention is a kind of micro- package spray-dried instrument of large size, including substrate 1；1 one table of substrate
Fixation is installed with one first support plate 101 and the second support plate 102 side by side in face；First support plate 101 and the second support plate 102 it
Between be connected by support rod 105, improve the stability and intensity of structure；First support plate, 101 1 surface is fixed with side by side
One first micro-injection pump 2 and one second micro-injection pump 3；Second support plate, 102 1 surface is fixed with an air pump 4 and one side by side
Blower 5；5 outlet air end of blower is connected with an electric heating tube 502 by a wind conveying pipe 501；Electric heating tube 502 includes that tube body and electricity add
Heated filament；Electric heating wire is circumferentially evenly arranged on inboard wall of tube body；Another surface of substrate 1 is fixed side by side to be installed with third support
Plate 103 and one the 4th support plate 104；4th support plate, 104 lower surface and 102 lower surface of the second support plate are fixed with branch side by side
Leg 106 improves the practical value of the equipment；A cabinet 6 is provided between third support plate 103 and the 4th support plate 104；Case
The side wall of body 6 is made of transparent high temperature resistant high-boron-silicon glass, so that entirely spray drying process visualization, facilitates staff
Operation；6 top of cabinet is installed with an outer barrel 7；7 central axis of outer barrel and 502 central axis of electric heating tube are perpendicular；Outer cylinder
7 central axis of body and 502 central axis of electric heating tube in the same plane, do not realize the eccentrically mounted of electric heating tube 502, from
And it ensure that hot wind to the drying effect of microlayer model；7 upper end of outer barrel is through cabinet 6 and third support plate 103 and extends to the
Three support plates, 103 top；7 upper end of outer barrel is connected with 502 one end of electric heating tube；The fixed installing in 7 lower end of outer barrel
There is the drying cavity 701 of the tapered structure in a lower end；Dry 701 lower end of cavity is installed with a collecting pipe 702；Outer barrel 7
Interior fixation is interspersed with the inner cylinder 8 of the tapered structure in a lower end；8 upper end of inner cylinder is connected with 401 one end of appendix；
An outer needle tubing 9 is installed in inner cylinder 8；Outer 9 upper end of needle tubing is connected with 201 one end of the first perfusion tube；Outer needle tubing 9 is built-in
Equipped with an inner needle tube 901；901 upper end of inner needle tube is connected with 301 one end of the second perfusion tube；7 side of outer barrel is simultaneously located at
The fixation of 6 top of cabinet, one surface is installed with a tornadotron 10；Tornadotron 10 is connected by a connecting tube 11 with dry cavity 701
It is logical；The fixation of 10 upper end of tornadotron is installed with an escape pipe 1001；The fixation of 10 lower end of tornadotron is installed with a micro mist receiving flask
1002。
It is worked by setting air pump 4 prior to the first micro-injection pump 2 and the second micro-injection pump 3, and holding first is micro
Syringe pump 2 is identical with the liquid speed rate out of the second micro-injection pump 3, is utilized respectively the outside injection of needle tubing 9 packet of the first micro-injection pump 2
When wrapping up in liquid and the second micro-injection pump 3 to 901 liquid medicine injection of inner needle tube, and being worked using air pump 4 at the lower port of inner cylinder 8
Draught head is generated, capillary flow phenomenon is based on, using swiftly flowing gas-powered, with certain in outer needle tubing 9 and inner needle tube 901
The target fluid of flow outflow converges to form composite conic and generate compound jet, and projects from the lower port of inner cylinder 8, compound
Jet stream is because unstability is broken into microlayer model, to realize the package to medical fluid；Pass through synchronous averaging blower 5 and electric heating tube
502, hot wind enters dry cavity 701 by outer barrel 7, makes broken microlayer model through the rapid draing of overfire air, and be arranged
Tornadotron 10 extends hot wind in the residence time of dry cavity 701, has reached energy-efficient purpose.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment
All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification,
It can make many modifications and variations.These embodiments are chosen and specifically described to this specification, is in order to better explain the present invention
Principle and practical application, so that skilled artisan be enable to better understand and utilize the present invention.The present invention is only
It is limited by claims and its full scope and equivalent.
Claims (7)
1. a kind of micro- package spray-dried instrument of large size, which is characterized in that including substrate (1)；
Fixation is installed with one first support plate (101) and the second support plate (102) side by side on (1) one surface of substrate；Described
(101) one surface of one support plate is fixed with one first micro-injection pump (2) and one second micro-injection pump (3) side by side；Described
(102) one surface of two support plates is fixed with an air pump (4) and a blower (5) side by side；Blower (5) outlet air end passes through a defeated wind
Pipe (501) is connected with an electric heating tube (502)；
Fixation is installed with a third support plate (103) and one the 4th support plate (104) side by side on the substrate (1) another surface；Institute
It states and is provided with a cabinet (6) between third support plate (103) and the 4th support plate (104)；Cabinet (6) top is installed with one
Outer barrel (7)；Outer barrel (7) upper end is through cabinet (6) and third support plate (103) and extends to third support plate
(103) top；Outer barrel (7) upper end is connected with electric heating tube (502) one end；Outer barrel (7) lower end
It is fixed to be installed with one dry cavity (701)；Dry cavity (701) lower end is installed with a collecting pipe (702)；
Fixation is interspersed with an inner cylinder (8) in the outer barrel (7)；Inner cylinder (8) upper end and appendix (401) one end
Portion is connected；An outer needle tubing (9) is installed in the inner cylinder (8)；Outer needle tubing (9) upper end and the first perfusion tube
(201) one end is connected；An inner needle tube (901) are installed in the outer needle tubing (9)；Inner needle tube (901) upper end with
Second perfusion tube (301) one end is connected；
Outer barrel (7) side and be located at one surface of cabinet (6) top fixation be installed with a tornadotron (10)；The tornadotron
(10) it is connected by a connecting tube (11) with dry cavity (701)；Tornadotron (10) the upper end fixation is installed with one and goes out
Tracheae (1001)；Tornadotron (10) the lower end fixation is installed with a micro mist receiving flask (1002).
2. the micro- package spray-dried instrument of a kind of large size according to claim 1, which is characterized in that first support plate
(101) it is connected between the second support plate (102) by support rod (105).
3. the micro- package spray-dried instrument of a kind of large size according to claim 1, which is characterized in that second support plate
(102) lower surface and the 4th support plate (104) lower surface are fixed with supporting leg (106) side by side.
4. the micro- package spray-dried instrument of a kind of large size according to claim 1, which is characterized in that the electric heating tube
It (502) include tube body and electric heating wire；The electric heating wire is circumferentially evenly arranged on inboard wall of tube body.
5. the micro- package spray-dried instrument of a kind of large size according to claim 1, which is characterized in that the side of the cabinet (6)
Wall is made of transparent high temperature resistant high-boron-silicon glass.
6. the micro- package spray-dried instrument of a kind of large size according to claim 1, which is characterized in that under the inner cylinder (8)
End and the dry tapered structure in cavity (701) lower end.
7. the micro- package spray-dried instrument of a kind of large size according to claim 1, which is characterized in that in the outer barrel (7)
Mandrel line and electric heating tube (502) central axis are perpendicular；Outer barrel (7) central axis and electric heating tube (502) center
Axis is not in the same plane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810869539.9A CN108905249A (en) | 2018-08-02 | 2018-08-02 | A kind of micro- package spray-dried instrument of large size |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810869539.9A CN108905249A (en) | 2018-08-02 | 2018-08-02 | A kind of micro- package spray-dried instrument of large size |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108905249A true CN108905249A (en) | 2018-11-30 |
Family
ID=64393933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810869539.9A Pending CN108905249A (en) | 2018-08-02 | 2018-08-02 | A kind of micro- package spray-dried instrument of large size |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108905249A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004092969A (en) * | 2002-08-30 | 2004-03-25 | Fuji Photo Film Co Ltd | Spray dryer |
| JP2008070809A (en) * | 2006-09-15 | 2008-03-27 | Ricoh Co Ltd | Spray coating apparatus for parts of electrophotographic apparatus, and method of manufacturing electrophotographic photoreceptor |
| CN205815879U (en) * | 2016-05-28 | 2016-12-21 | 安徽广信农化股份有限公司 | A kind of for carbendazim production reducing mechanism |
| CN106573181A (en) * | 2014-03-31 | 2017-04-19 | 安邦国际有限公司 | Improved spray drying process for production of powders with enhanced properties |
| CN106924046A (en) * | 2017-04-24 | 2017-07-07 | 中国科学技术大学 | Medicine-carrying capsule prepares shower nozzle and medicine-carrying capsule preparation facilities |
| CN207384871U (en) * | 2017-10-26 | 2018-05-22 | 吉安市御美丽健康产业股份有限公司 | A kind of pharmaceutical purpose spray dryer |
| CN209033777U (en) * | 2018-08-02 | 2019-06-28 | 合肥中科力一科技有限公司 | A kind of micro- package spray-dried instrument of large size |
-
2018
- 2018-08-02 CN CN201810869539.9A patent/CN108905249A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004092969A (en) * | 2002-08-30 | 2004-03-25 | Fuji Photo Film Co Ltd | Spray dryer |
| JP2008070809A (en) * | 2006-09-15 | 2008-03-27 | Ricoh Co Ltd | Spray coating apparatus for parts of electrophotographic apparatus, and method of manufacturing electrophotographic photoreceptor |
| CN106573181A (en) * | 2014-03-31 | 2017-04-19 | 安邦国际有限公司 | Improved spray drying process for production of powders with enhanced properties |
| CN205815879U (en) * | 2016-05-28 | 2016-12-21 | 安徽广信农化股份有限公司 | A kind of for carbendazim production reducing mechanism |
| CN106924046A (en) * | 2017-04-24 | 2017-07-07 | 中国科学技术大学 | Medicine-carrying capsule prepares shower nozzle and medicine-carrying capsule preparation facilities |
| CN207384871U (en) * | 2017-10-26 | 2018-05-22 | 吉安市御美丽健康产业股份有限公司 | A kind of pharmaceutical purpose spray dryer |
| CN209033777U (en) * | 2018-08-02 | 2019-06-28 | 合肥中科力一科技有限公司 | A kind of micro- package spray-dried instrument of large size |
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