CN108904506A - A kind of diclazuril nanometer powder and preparation method thereof - Google Patents
A kind of diclazuril nanometer powder and preparation method thereof Download PDFInfo
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- CN108904506A CN108904506A CN201810843178.0A CN201810843178A CN108904506A CN 108904506 A CN108904506 A CN 108904506A CN 201810843178 A CN201810843178 A CN 201810843178A CN 108904506 A CN108904506 A CN 108904506A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Abstract
The present invention relates to a kind of diclazuril nanometer powders and preparation method thereof, raw material and auxiliary material composition including following parts by weight：Raw material：3-8 parts of diclazuril, auxiliary material：30-60 parts of stabilizer, is granulated auxiliary material 600-1000 parts, 20-50 parts of anticaking agent at 3-8 parts of surfactant；The nano particle diameter that the present invention is generated using ball mill uniformly contains enough crystal defects, it can be effectively suppressed and regroups into microparticle, greatly improve the surface area of diclazuril, reduce the partial size of drug, so that all containing main ingredient in each finished product, so that the probability that drug is uniformly mixed in feed increases, so that the probability of feed intake increases, to improve its mixture homogeneity and bioavilability in feed, greatly improve the using effect of diclazuril, nanomorphic drug promotes the absorption of drug, simple process, large-scale production can be achieved, there is universality for a variety of drugs.
Description
Technical field
The invention belongs to technical field of veterinary more particularly to a kind of diclazuril nanometer powder and preparation method thereof.
Background technique
Diclazuril (Diclazuril) belongs to triazine benzene acetonitrile compound, and chemical name is bis- chloro- 2- (4- chlorine of 2,6-
Benzene) -4- (4,5- dihydro -3,5- dioxos -1,2,4- triazine -2 (3H)-yl) benzene acetonitrile, is also chlorine piperazine phenethyl cyanogen.Molecular formula is
C17H9Cl3N4O2, molecular weight 407.64.The medicine be off-white color or pale yellow powder, it is almost odorless, in N, N- dimethyl
Formamide（DMF）It is middle slightly molten, it is almost insoluble in water, ethyl alcohol.Diclazuril is novel, efficient, less toxic anticoccidial drug, is used extensively
In various globidiosis.Chicken coccidiasis be chick commonly-occurring disease and endanger extremely serious, chick disease incidence highest more than 15 ages in days,
The death rate may be up to 80% or more, and the chick growth recovered is obstructed, and cannot restore for a long time, very to the loss of poultry husbandry bring
It is huge.Say that diclazuril has good control efficiency to the various coccidias of chicken from pharmacology, while to turkey, duck, goose, hole
The various birds of sparrow, quail, rabbit etc. should have good result.
The medicine belongs to non-ionic anticoccidial drug, it and coban, salinomycin, Maduamicin A plasma type polyethers
The anticoccidial drug of antibiotic and the anticoccidial drug of other synthesis are that current dosage is minimum, anticoccidial is composed most without cross-resistance
Extensively, it does not need to be discontinued before butchering, uses a kind of safest novel against-coccidia medicine.
At present《Chinese veterinary pharmacopoeia version in 2015》Including diclazuril preparation has oral solution, pre-mixing agent.With ground gram pearl
Benefit is the anticoccidial drug of raw material from pharmacologically saying, using effect should be very good, but the either oral solution in production and application
Or pre-mixing agent all falls flat.It is found through investigation：
（1）Diclazuril oral liquid makees solvent through common dimethylformamide, and oral administration solution, which is added in water, drinks chicken freely, by
In oral administration solution, concentration is lower in water, and diclazuril is precipitated in water quickly, causes oral failure, and effect is poor.
（2）Diclazuril pre-mixing agent by hybrid technique production in use, every 1000Kg complete feed adds diclazuril 1g,
It is difficult to stir evenly, largely oral failure, effect are poor for jumpbogroup chicken.
（3）Diclazuril is insoluble in water, and the utilization rate in alimentary canal is lower.
Summary of the invention
Present invention aims to overcome that the deficiencies in the prior art and a kind of diclazuril nanometer powder that provides and
Preparation method.
The object of the present invention is achieved like this：A kind of diclazuril nanometer powder, it is characterised in that：Including following weight
The raw material and auxiliary material of number form：Raw material：3-8 parts of diclazuril, auxiliary material：30-60 parts of stabilizer, is made 3-8 parts of surfactant
Grain 600-1000 parts of auxiliary material, 20-50 parts of anticaking agent.
A kind of diclazuril nanometer powder, it is characterised in that：Raw material and auxiliary material composition including following parts by weight：It is former
Material：4-6 parts of diclazuril, auxiliary material：40-55 parts of stabilizer, is granulated auxiliary material 800-950 parts, anticaking agent at 4-6 parts of surfactant
30-40 parts.
A kind of diclazuril nanometer powder, it is characterised in that：Raw material and auxiliary material composition including following parts by weight：It is former
Material：5 parts of diclazuril, auxiliary material：55 parts of stabilizer, is granulated 900 parts of auxiliary material, 35 parts of anticaking agent at 5 parts of surfactant.
A kind of preparation method of diclazuril nanometer powder, it is characterised in that：It has follow steps：
Step 1）, diclazuril uniformly mixed with surfactant, mixed diclazuril and surfactant are put into
It is ground into ball mill, ratio of grinding media to material when grinding is 1：1~20：1, drum's speed of rotation is 500rpm ~ 1500rpm, and milling time is
2-24 hours, the diameter being ground was 50nm-150nm, and abrasive flour is obtained after the completion of grinding, spare；
Step 2）, stabilizer is put into 150-200 parts of purified water and is impregnated, water temperature be 30 °C -40 °C, all dissolution after, to
1-20 parts of granulation auxiliary material is added in dissolved solution, obtains mixed liquor, mixed liquor is stirred using high-shear emulsion machine
It mixes, speed of agitator 30-80r/min, mixing time is 10-30 minutes；
Step 3）, step 2）In mixed liquor stirring complete after, do not stop the stirring of high-shear emulsion machine, by step 1）In obtain
The abrasive flour obtained is added in mixed liquor, continues to stir using emulsification pretreatment machine, and the stirring after abrasive flour is added turns
Speed is 8000-14000r/min, and mixing time is 30-60 minutes；Pulpous state liquid is obtained, it is spare；
Step 4）, by step 3）The pulpous state liquid of acquisition is put into compression sprayer, by the granulation auxiliary material of remaining deal and is resisted
Knot agent is put into flat mixer, is stirred mixing with flat mixer, and stirring while will slurry with compression sprayer
Shape liquid be sprayed onto the form of mist body in the mixing machine of bedroom carry out it is uniformly mixed；Atomisation pressure is 0.50-0.85 MPa, and mixing is completed
Soft material is made afterwards；
Step 5）, by step 4）The soft material of acquisition, which is put into granulator, pelletizes, and particle diameter obtained is 2mm-4mm；
Step 6）, by step 5）Particle obtained, which is put into fluid-bed drier, to be dried, drying temperature be 30 °C-
110 °C, intake 10m3/min-15m3/min；Drying time is 20-40 minutes；
Step 7）, it is dry complete after, the particle after drying is put into pulverizer and is crushed, raw medicine powder is obtained, it is former
The mesh number at medicinal powder end is 100-150 mesh；
Step 8）Raw medicine powder is sieved using reciprocating sieve, is used《Chinese veterinary pharmacopoeia》No. 6 sieves of defined standard carry out
Screening, unacceptable raw medicine powder re-starts crushings, by raw medicine powder be described in diclazuril nanometer powder.
The stabilizer is pectic acid sodium, carragheen, chitosan, guar gum, Chinese yam starch, xanthan gum, lactose, hydroxypropyl
One of ylmethyl cellulose, polyoxyethylene ether, sodium alginate, beta-cyclodextrin, Arabic gum, gelatin, polyethylene glycol-8 000
Or it is a variety of.
The surfactant is glyceric acid aliphatic ester, diacetyl tartaric acid, monoricinolein, dodecyl benzene sulfonic acid
Sodium, polyethylene glycol-400, Tween-80, dodecyl sodium sulfate, sorbitan mono-laurate, anhydrous sorbitol list
One of stearate, polyoxyethylene, sorbitan monooleate are a variety of.
The granulation auxiliary material be Assam treasured rummy starch, starch from sweet potato, microcrystalline cellulose, maltodextrin, glucose,
One of sucrose is a variety of.
The anticaking agent is one of talcum powder, silicon dioxide powder, magnesium stearate or a variety of.
The nano particle diameter that the present invention is generated using ball mill uniformly contains enough crystal defects, and it is heavy that its can be effectively suppressed
Microparticle newly is aggregated into, greatly improves the surface area of diclazuril, reduces the partial size of drug, so that in each finished product
All contain main ingredient.So that the probability that drug is uniformly mixed in feed increases, so that the probability of feed intake increases, to improve it
Mixture homogeneity and bioavilability in feed, greatly improve the using effect of diclazuril, and nanomorphic drug promotes
The absorption of drug, simple process have universality for a variety of drugs, it can be achieved that large-scale production.
Detailed description of the invention
The diclazuril pre-mixing agent raw material carrier distribution map that Fig. 1 conventional mixing method is formed；
The diclazuril nanometer powder that Fig. 2 preparation method of the present invention is formed.
Specific embodiment
Embodiment 1：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Arabic gum 55g, dodecyl sodium sulfate 5g, starch from sweet potato 600g, sucrose 300g, magnesium stearate 35g.
A kind of preparation method of diclazuril nanometer powder, it is characterised in that：It has follow steps：
Step 1）, diclazuril uniformly mixed with dodecyl sodium sulfate, by mixed diclazuril and dodecyl sulphur
Sour sodium, which is put into ball mill, to be ground, the preferred planetary ball mill of ball mill, and ratio of grinding media to material when grinding is 5：1, drum's speed of rotation
For 1000rpm, milling time is 5 hours, and the diameter being ground is 100nm, and abrasive flour is obtained after the completion of grinding, spare.
Step 2）, Arabic gum is put into the purified water of 200g and is impregnated, water temperature be 35 °C, all dissolution after, to dissolution
The starch of 10g is added in solution afterwards, obtains mixed liquor, mixed liquor is stirred using high-shear emulsion machine, speed of agitator
For 50r/min, mixing time is 20 minutes；In step 2）In, be first added 10g starch be to be able to make solution preferably at
Slurry dress, can make the even density of entire solution, avoid some species precipitates to the bottom of solution.And pass through stirring for low speed
It mixes, Arabic gum is enable preferably to fuse, if using high-speed stirred in step 2, will lead to Arabic gum cannot be complete
Fused with purified water, cause fused unevenness.
Step 3）, step 2）In mixed liquor stirring complete after, do not stop the stirring of high-shear emulsion machine, by step 1）
The abrasive flour of middle acquisition is added in mixed liquor, continues to stir using emulsification pretreatment machine, stirring after abrasive flour is added
Mixing revolving speed is 12000r/min, and mixing time is 40 minutes；Pulpous state liquid is obtained, it is spare；In the step 3）It is middle to use high-speed stirring
It mixes, and stirs longer time, high-speed stirred can be such that abrasive flour is rapidly diffused into mixed liquor, and in order to make to grind
Powder is spread uniform, it is necessary to extend mixing time.
Step 4）, by step 3）The pulpous state liquid of acquisition is put into compression sprayer, by the starch of remaining 590g, 300g
Sucrose and 35g magnesium stearate, be put into flat mixer, be stirred mixing with flat mixer, while stirring
Pulpous state liquid is sprayed onto flat mixer in the form of mist body with compression sprayer carry out it is uniformly mixed；Atomisation pressure is 0.60
Soft material is made after the completion of mixing in MPa；In step 4）In, it is sprayed while stirring, until having sprayed pulpous state liquid, leads to
Excess pressure sprayer can be such that pulpous state liquid is sprayed onto flat mixer with superfine mist agent, pulpous state liquid can be made to be uniformly distributed in remaining
In the magnesium stearate of the starch of 590g, the sucrose of 300g and 35g, equally distributed soft material can be made.
Step 5）, by step 4）The soft material of acquisition, which is put into granulator, pelletizes, and particle diameter obtained is 3mm.
Step 6）, by step 5）Particle obtained, which is put into fluid-bed drier, to be dried, and drying temperature is 50 °C,
Intake is 12m3/min；Drying time is 30 minutes；It is made into the present invention after particle, water content is less in particle, makes
It is difficult for the moisture in particle to be evaporated with common drying machine, and fluid-bed drier can be good at playing to particle
The effect of drying, drying effect are more uniform.
Step 7）, it is dry complete after, the particle after drying is put into pulverizer and is crushed, raw medicine powder is obtained
End, the mesh number of raw medicine powder are 150 mesh.
Step 8）Raw medicine powder is sieved using reciprocating sieve, is used《Chinese veterinary pharmacopoeia》No. 6 sieves of defined standard
Sieved, unacceptable raw medicine powder re-starts crushing, by raw medicine powder be the diclazuril nano powder
End.
Through overtesting, diclazuril nanometer powder obtained by embodiment, according to《Chinese veterinary pharmacopoeia 2015 editions》It is required that progressive
The measurement such as shape and content, meets the requirements.
Diclazuril nanosizing handles manufactured preparation granules, uniformly contains diclazuril in each preparation granules, makes to contain
There is the granule number of diclazuril averagely to increase 100 times or more compared with raw material diclazuril, is added to very much by hundred a ten thousandths
One of addition.It is tested its feed mixture homogeneity coefficient of variation and reaches related requirement.
The bioavilability of diclazuril greatly improves, and remains comparative experiments through excrement, is greatly lowered with control group.
The drug effect of real diclazuril nanometer powder as evidence has carried out experiment and has been verified to its effect.Using artificial warp
100,000 Eimeria tenella Sporulated Oocysts are inoculated on the AA Broiler chicks of 11 ages in days by the mode of crop infection, are determined
The effect of diclazuril nanometer powder, and with A group diclazuril original powder（98%（W/W）0.5% pre-mixing agent is synthesized for raw material premix to make
For control drug.Experimental result is as shown in Table 1：
Table one：Diclazuril nanometer powder experimental result
| Experimental group | Spice administration concentration（As active ingredients） | Chicken number | Survival rate | The relative weight gain % | Egg capsule ratio | ACI |
| Blank group | 0 | 200 | 34% | 43% | 100 | 0 |
| A group | 1g/t | 200 | 62% | 71% | 30.1 | |
| 1 gained drug of embodiment | 1g/t | 200 | 100% | 97% | 0 |
Experiment conclusion：It can be seen that from the experimental result of table one：The application of diclazuril nanometer powder pre-mixing agent can be mentioned effectively
High anticoccidial effect.
Preparation method is same as Example 1 in following embodiment, and auxiliary material is directly replaced, and repeats no more.
Embodiment 2：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Sodium alginate 65g, dodecyl sodium sulfate 3g, microcrystalline cellulose 700g, maltodextrin 200g, titanium dioxide
Silicon powder 25g.
Embodiment 3：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Hydroxypropyl methyl cellulose element 45g, polyoxyethylene ether 30g, Tween-80 3g, starch 500g, wheat
Bud dextrin 423g, talcum powder 25g.
Embodiment 4：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Beta-cyclodextrin 65g, dodecyl sodium sulfate 3g, microcrystalline cellulose 700g, maltodextrin 200g, titanium dioxide
Silicon powder 25g.
Embodiment 5：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Hydroxypropyl methyl cellulose 65g, dodecyl sodium sulfate 3g, microcrystalline cellulose 700g, maltodextrin
200g, silicon dioxide powder 25g.
Embodiment 6：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Polyoxyethylene ether 65g, dodecyl sodium sulfate 3g, microcrystalline cellulose 700g, maltodextrin 200g, dioxy
SiClx powder 25g.
Embodiment 7：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Beta-cyclodextrin 65g, dodecyl sodium sulfate 3g, microcrystalline cellulose 700g, maltodextrin 200g, titanium dioxide
Silicon powder 25g.
Embodiment 8：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Sodium alginate 65g, sorbitan monooleate 3g, microcrystalline cellulose 700g, maltodextrin 200g, two
Silica powder 25g.
Embodiment 9：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：Ground
Gram pearl benefit 5g, auxiliary material：Sodium alginate 65g, sorbitan mono-laurate 3g, microcrystalline cellulose 700g, maltodextrin 200g,
Silicon dioxide powder 25g.
Embodiment 10：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Sodium alginate 65g, dodecyl sodium sulfate 3g, Assam treasured rummy starch 700g, maltodextrin
200g, silicon dioxide powder 25g.
Embodiment 11：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Sodium alginate 65g, dodecyl sodium sulfate 3g, microcrystalline cellulose 700g, maltodextrin 200g, tristearin
Sour magnesium 25g.
Embodiment 12：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：It is hydroxypropyl methyl cellulose element 45g, sorbitan monooleate 30g, Tween-80 3g, red
Sweet potato starch 500g, maltodextrin 423g, talcum powder 25g.
Embodiment 13：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：It is hydroxypropyl methyl cellulose element 45g, polyoxyethylene ether 30g, sorbitan monooleate 3g, red
Sweet potato starch 500g, maltodextrin 423g, talcum powder 25g.
Embodiment 14：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Beta-cyclodextrin 45g, polyoxyethylene ether 30g, sorbitan monooleate 3g, microcrystalline cellulose
500g, maltodextrin 423g, talcum powder 25g.
Embodiment 15：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Hydroxypropyl methyl cellulose element 45g, polyoxyethylene ether 30g, Tween-80 3g, Assam treasured are drawn
Rice starch 500g, maltodextrin 423g, silicon dioxide powder 25g.
Embodiment 16：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Hydroxypropyl methyl cellulose element 45g, polyoxyethylene ether 30g, polyethylene glycol-400 3g, Assam are precious
Rummy starch 500g, maltodextrin 423g, magnesium stearate 25g.
Embodiment 17：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Guar gum 45g, diacetyl tartaric acid 30g, Tween-80 3g, starch from sweet potato 500g, malt paste
Smart 423g, talcum powder 25g.
Embodiment 18：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Hydroxypropyl methyl cellulose element 45g, polyoxyethylene ether 30g, monoricinolein 3g, microcrystalline cellulose
500g, maltodextrin 423g, talcum powder 25g.
Embodiment 19：A kind of diclazuril nanometer powder, raw material and auxiliary material composition including following parts by weight：Raw material：
Diclazuril 5g, auxiliary material：Hydroxypropyl methyl cellulose element 45g, polyoxyethylene ether 30g, Tween-80 3g, glucose
500g, maltodextrin 423g, silicon dioxide powder 25g.
Claims (8)
1. a kind of diclazuril nanometer powder, it is characterised in that：Raw material and auxiliary material composition including following parts by weight：Raw material：
3-8 parts of diclazuril, auxiliary material：30-60 parts of stabilizer, is granulated auxiliary material 600-1000 parts, anticaking agent 20- at 3-8 parts of surfactant
50 parts.
2. a kind of diclazuril nanometer powder, it is characterised in that：Raw material and auxiliary material composition including following parts by weight：Raw material：
4-6 parts of diclazuril, auxiliary material：40-55 parts of stabilizer, is granulated auxiliary material 800-950 parts, anticaking agent 30- at 4-6 parts of surfactant
40 parts.
3. a kind of diclazuril nanometer powder, it is characterised in that：Raw material and auxiliary material composition including following parts by weight：Raw material：
5 parts of diclazuril, auxiliary material：55 parts of stabilizer, is granulated 900 parts of auxiliary material, 35 parts of anticaking agent at 5 parts of surfactant.
4. a kind of preparation method of diclazuril nanometer powder, it is characterised in that：It has follow steps：
Step 1）, diclazuril uniformly mixed with surfactant, mixed diclazuril and surfactant are put into
It is ground into ball mill, ratio of grinding media to material when grinding is 1：1~20：1, drum's speed of rotation is 500rpm ~ 1500rpm, and milling time is
2-24 hours, the diameter being ground was 50nm-150nm, and abrasive flour is obtained after the completion of grinding, spare；
Step 2）, stabilizer is put into 150-200 parts of purified water and is impregnated, water temperature be 30 °C -40 °C, all dissolution after, to
1-20 parts of granulation auxiliary material is added in dissolved solution, obtains mixed liquor, mixed liquor is stirred using high-shear emulsion machine
It mixes, speed of agitator 30-80r/min, mixing time is 10-30 minutes；
Step 3）, step 2）In mixed liquor stirring complete after, do not stop the stirring of high-shear emulsion machine, by step 1）In obtain
The abrasive flour obtained is added in mixed liquor, continues to stir using emulsification pretreatment machine, and the stirring after abrasive flour is added turns
Speed is 8000-14000r/min, and mixing time is 30-60 minutes；Pulpous state liquid is obtained, it is spare；
Step 4）, by step 3）The pulpous state liquid of acquisition is put into compression sprayer, by the granulation auxiliary material of remaining deal and is resisted
Knot agent is put into flat mixer, is stirred mixing with flat mixer, and stirring while will slurry with compression sprayer
Shape liquid be sprayed onto the form of mist body in the mixing machine of bedroom carry out it is uniformly mixed；Atomisation pressure is 0.50-0.85 MPa, and mixing is completed
Soft material is made afterwards；
Step 5）, by step 4）The soft material of acquisition, which is put into granulator, pelletizes, and particle diameter obtained is 2mm-4mm；
Step 6）, by step 5）Particle obtained, which is put into fluid-bed drier, to be dried, drying temperature be 30 °C-
110 °C, intake 10m3/min-15m3/min；Drying time is 20-40 minutes；
Step 7）, it is dry complete after, the particle after drying is put into pulverizer and is crushed, raw medicine powder is obtained, it is former
The mesh number at medicinal powder end is 100-150 mesh；
Step 8）Raw medicine powder is sieved using reciprocating sieve, is used《Chinese veterinary pharmacopoeia》No. 6 sieves of defined standard carry out
Screening, unacceptable raw medicine powder re-starts crushings, by raw medicine powder be described in diclazuril nanometer powder.
5. a kind of diclazuril nanometer powder according to claim 1, it is characterised in that：The stabilizer is pectic acid
Sodium, carragheen, chitosan, guar gum, Chinese yam starch, xanthan gum, lactose, hydroxypropyl methyl cellulose, polyoxyethylene ether, seaweed
One of sour sodium, beta-cyclodextrin, Arabic gum, gelatin, polyethylene glycol-8 000 are a variety of.
6. a kind of diclazuril nanometer powder according to claim 1, it is characterised in that：The surfactant is sweet
Oleic acid aliphatic ester, diacetyl tartaric acid, monoricinolein, neopelex, polyethylene glycol-400, Tween-80,
Dodecyl sodium sulfate, sorbitan mono-laurate, sorbitan monostearate, polyoxyethylene, anhydrous sorbitol
One of monoleate is a variety of.
7. a kind of diclazuril nanometer powder according to claim 1, it is characterised in that：The granulation auxiliary material is Ah Sa
One of nurse treasured rummy starch, starch from sweet potato, microcrystalline cellulose, maltodextrin, glucose, sucrose are a variety of.
8. a kind of diclazuril nanometer powder according to claim 1, it is characterised in that：The anticaking agent is talcum
One of powder, silicon dioxide powder, magnesium stearate are a variety of.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394697A (en) * | 2018-11-30 | 2019-03-01 | 合肥中龙神力动物药业有限公司 | A kind of diclazuril sustained release preparation and preparation method thereof for preventing and treating chicken coccidiosis of rabbit |
| CN110123767A (en) * | 2019-06-20 | 2019-08-16 | 河南大华生物技术有限公司 | It is a kind of to make safe preparation for rumen of antibiotic and preparation method thereof |
| CN110123764A (en) * | 2019-06-20 | 2019-08-16 | 河南大华生物技术有限公司 | A kind of 25- hydroxy-vitamin D3 nanometer powder and preparation method thereof |
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| CN110123764A (en) * | 2019-06-20 | 2019-08-16 | 河南大华生物技术有限公司 | A kind of 25- hydroxy-vitamin D3 nanometer powder and preparation method thereof |
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