CN108889409B - Granular agent forming device, forming method and granular agent - Google Patents
Granular agent forming device, forming method and granular agent Download PDFInfo
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- CN108889409B CN108889409B CN201810697481.4A CN201810697481A CN108889409B CN 108889409 B CN108889409 B CN 108889409B CN 201810697481 A CN201810697481 A CN 201810697481A CN 108889409 B CN108889409 B CN 108889409B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/08—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers
- B02C18/10—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers with drive arranged above container
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C1/00—Crushing or disintegrating by reciprocating members
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
- B02C18/18—Knives; Mountings thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
- B02C23/08—Separating or sorting of material, associated with crushing or disintegrating
- B02C23/16—Separating or sorting of material, associated with crushing or disintegrating with separator defining termination of crushing or disintegrating zone, e.g. screen denying egress of oversize material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/18—Drum screens
- B07B1/22—Revolving drums
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
- B07B1/4609—Constructional details of screens in general; Cleaning or heating of screens constructional details of screening surfaces or meshes
Abstract
The invention relates to a granule forming device, a granule forming method and granules, wherein the granule forming device comprises a first rotary cylinder (1), a first motor (5), a crushing unit (6), a grinding unit (12) and a granule forming unit (19), a second fan (28) blows airflow to enable granules smaller than a preset first particle size to pass through a filter screen (27), a circulating channel (29) used for circulating granules larger than the preset first particle size to the lower portion of a second rotary cylinder (24) is provided with the lowest end side of the filter screen (27), a cyclone separator (30) is arranged, granules larger than the preset second particle size are upwards discharged through the cyclone separator (30), and granules smaller than the preset second particle size enter the circulating channel (29).
Description
Technical Field
The invention belongs to the field of medicine preparation, and particularly relates to a granule forming device, a granule forming method and granules.
Background
Pharmaceutical granulation methods can be divided into three main categories: wet granulation, dry granulation, spray granulation, wherein wet granulation is most widely used. Wet granulation is a process in which a binder is added to a drug powder and the powder is agglomerated together by the bridging or binding action of the binder to produce granules. The method has the advantages that the surface of the particles prepared by the wet method is wet, and the particles have the advantages of good quality, attractive appearance, strong wear resistance, good compression molding property and the like, however, most of the existing wet granulation methods have the defects of high energy consumption, low precision, uneven particle size, uneven content and the like, and the defects are difficult to overcome in the actual production process.
Therefore, an urgent need in the art is to provide a granule forming apparatus, a granule forming method, and a granule, which can improve uniformity of content and uniformity of particle size, improve preparation efficiency, save cost and energy consumption, and have a simple structure.
The above information disclosed in this background section is only for enhancement of understanding of the background of the invention and therefore it may contain information that does not form the prior art that is already known in this country to a person of ordinary skill in the art.
Disclosure of Invention
The present inventors have conducted intensive studies to achieve the above object, and more particularly, the present invention provides a granule forming apparatus comprising,
a first rotary cylinder body which comprises an annular feed inlet arranged at the top for controllably feeding raw materials of granules, a closed outer cylinder wall and a conical screen cylinder arranged at the bottom for screening,
the first motor is used for driving the first rotary cylinder body to rotate at a first rotating speed, is connected with the first rotary cylinder body and is positioned below the conical screen cylinder,
the crushing unit is used for crushing raw materials and is arranged in the first rotary cylinder body, the crushing unit is driven by a second motor to rotate at an adjustable second rotating speed, the crushing unit comprises a left inverted trapezoidal crushing body and a right inverted trapezoidal crushing body, the left inverted trapezoidal crushing body and the right inverted trapezoidal crushing body are matched with the conical screen cylinder and are arranged, the left inverted trapezoidal crushing body and/or the right inverted trapezoidal crushing body are/is provided with a plurality of triangular grooves which are gradually reduced from top to bottom, the outer surfaces of the left inverted trapezoidal crushing body and/or the right inverted trapezoidal crushing body and the triangular grooves on the left inverted trapezoidal crushing body and/or the right inverted trapezoidal crushing body are respectively provided with a crushing blade,
a grinding unit disposed below the conical screen drum for receiving and grinding the powder of the raw material sieved through the conical screen drum, the grinding unit including a rotatable arc-shaped grinding body, a grinding hammer, and a spray head for spraying a predetermined amount of adhesive, the grinding body being driven to rotate at a third rotational speed by a third motor, the grinding hammer moving up and down at a linear speed by a telescopic cylinder, the grinding body being provided with a discharge valve for discharging the ground powder,
a particle-forming unit comprising:
a particle-forming outer shell having an inner wall provided with a plurality of axially aligned, obliquely upward undulations comprising arcuate projections and arcuate recesses adjacent to each other,
a second rotating cylinder adjustably rotated in the particle forming enclosure at a fourth rotational speed via a second rotating cylinder driven by a third motor,
a feeding channel for pumping the powder to the particle forming unit and connecting the feeding channel with the discharge valve, wherein a first fan for generating gas carrier is arranged in the feeding channel, the powder is extruded by the second rotary cylinder from bottom to top along the fluctuation structure through the gas carrier to form granules,
a filter screen obliquely arranged above the second rotary cylinder body,
a second fan blowing an air flow so that the granules smaller than a predetermined first particle diameter pass through the filter screen,
a circulating channel for circulating the granules with the particle size larger than the preset first particle size to one side of the lowest end of the filter screen arranged on the circulating channel below the second rotary cylinder,
and the cyclone separator is used for upwards discharging the granules with the particle size larger than the preset second particle size, and the granules with the particle size smaller than the preset second particle size enter the circulating channel.
In the granule forming device, the annular feeding hole is connected with an electromagnetic valve used for controlling the feeding speed and the feeding amount, and the grinding body is connected with a third motor through a speed reducer.
In the granule forming device, a stirring blade for stirring is arranged on the horizontal part of the conical screen drum at the lowest end of the left inverted trapezoidal crushing body and/or the right inverted trapezoidal crushing body, and the left inverted trapezoidal crushing body and the right inverted trapezoidal crushing body are bilaterally symmetrical.
In the granule forming device, the granule forming device comprises a liquid crystal touch screen and a frequency converter for regulation and control, wherein the frequency converter is electrically connected with a first fan, a second fan, a spray head and/or a first motor, a second motor, a third motor and a third motor.
Granule forming device in the direction of first rotational speed and second to fourth rotational speed opposite direction, speed is fourth rotational speed, second rotational speed, third rotational speed and first rotational speed from big to little in proper order, the ascending undulation structure's of a plurality of inclinations arc protrusion and arc recess form spiral ascending extrusion passageway.
In the granule forming device, the granule forming device comprises a control device for controlling the process, the control device is wirelessly connected with the first fan, the second fan, the spray head and/or the first motor, the second fan, the spray head and/or the third motor through a wireless communication device, the control device comprises a digital signal processor, an Application Specific Integrated Circuit (ASIC) or a Field Programmable Gate Array (FPGA), and the control device comprises a memory which can comprise one or more Read Only Memories (ROM), Random Access Memories (RAM), flash memories or Electrically Erasable Programmable Read Only Memories (EEPROM).
In the granule forming device, the control device is a mobile phone, a pad or a cloud server.
In the granule forming device, the wireless communication device at least comprises a wireless local area network communication device and/or a mobile communication network device, the mobile communication network device comprises a 2G/3G/4G wireless communication chip, and the wireless local area network communication device comprises one of a Bluetooth module, a ZigBee module or a Wi-Fi module.
In another aspect of the present invention, a forming method using the granule forming apparatus includes the steps of:
a first step of controllably feeding a predetermined amount of raw material for granules from the ring-shaped feed port, the first rotary cylinder rotating at a first rotational speed, the crushing unit rotating at a second rotational speed opposite to the first rotational speed, the left and/or right inverted trapezoidal crushing bodies and the crushing blades on the outer surfaces of the triangular recesses thereon crushing the raw material multiple times to form powder,
a second step of spraying a predetermined amount of the adhesive by a spray head, rotating the grinding body at a third rotational speed opposite to the first rotational speed by driving of a third motor, moving up and down the grinding hammer at a linear speed by a telescopic cylinder to grind the powder with the adhesive,
and a third step of conveying the powder from the discharge valve to the particle forming unit through a gas carrier, wherein the second rotary cylinder body is adjustably rotated in the particle forming shell at a fourth rotating speed, the powder is pressed by the second rotary cylinder body from bottom to top along the fluctuation structure to form granules, the second fan blows airflow to enable the granules smaller than the preset first particle size to pass through the filter screen, the granules larger than the preset second particle size are upwards discharged through the cyclone separator to become qualified granules, and the granules larger than the preset first particle size are circulated to the circulating channel below the second rotary cylinder body to be pressed again.
According to still another aspect of the present invention, a granule is formed by the forming method.
The invention has the following technical effects:
the annular feed inlet can uniformly and controllably input the raw materials into the left inverted trapezoid crushing body and the right inverted trapezoid crushing body of the crushing unit, compared with a single feed inlet or a feed hopper in the prior art, the blanking uniformity is obviously improved, the crushing efficiency of the raw materials is improved, the crushing blades arranged on the outer surfaces of the left inverted trapezoid crushing body and/or the right inverted trapezoid crushing body and the triangular groove on the left inverted trapezoid crushing body and/or the right inverted trapezoid crushing body can crush the raw materials in multiple times in the falling process, the crushing effect is gradually improved as the space is smaller downwards due to matching with the shape of the conical screen cylinder, on the basis that the first rotary cylinder body and the crushing unit rotate oppositely and are different, the conical screen cylinder can repeatedly eject the raw materials which are not sieved onto the crushing unit upwards, and further, the crushing blades on the triangular groove are arranged to crush the multiple times all the time, compared with the prior art, the crushing effect of the crushing unit is remarkably improved, the rotary grinding body and the linear-motion grinding hammer are uniformly mixed with the adhesive and the powder for full grinding, the uniformity of particles and the uniformity of particle size are further improved, the third motor drives the grinding body and the second rotary cylinder body simultaneously, the structure is simplified, the cost is saved, the powder moves from bottom to top along the fluctuation structure through the gas carrier, the ground powder containing the adhesive is extruded into granules by the arc-shaped protrusions and the arc-shaped grooves which are adjacent to each other, the spiral upward extrusion channels formed by the arc-shaped protrusions and the arc-shaped grooves in the plurality of upward inclination fluctuation structures can stably and efficiently form the granules with high uniformity, the second fan blows air flow to enable the granules smaller than the preset first particle size to pass through the filter screen, the screening efficiency is improved by the inclined arrangement of the filter screen, the granules passing through the filter screen are easy to be input into the cyclone separator, and the granules which do not At the inlet of the channel, granules with the particle size larger than the preset second particle size are discharged upwards through the cyclone separator, so that the particle size consistency of the formed granules is ensured, and the granules which do not meet the conditions are recycled and extruded by the circulating channel, so that the cost is saved.
Drawings
Fig. 1 is a schematic view of the overall structure of one embodiment of the granule forming apparatus of the present invention.
Fig. 2 is a schematic view of the steps of the forming method using the granule forming apparatus according to the present invention.
Detailed Description
Specific embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While specific embodiments of the invention are shown in the drawings, it should be understood that the invention may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the invention, but is made for the purpose of illustrating the general principles of the invention and not for the purpose of limiting the scope of the invention. The scope of the present invention is defined by the appended claims.
For the purpose of facilitating an understanding of the embodiments of the present invention, the following description will be made in terms of several specific embodiments with reference to the accompanying drawings, and the drawings are not intended to limit the embodiments of the present invention.
Specifically, as shown in fig. 1, a granule forming apparatus of the present invention includes,
a first rotary cylinder body 1 which comprises an annular feed inlet 2 arranged at the top for controllably feeding raw materials of granules, a closed outer cylinder wall 3 and a conical screen cylinder 4 arranged at the bottom for screening,
a first motor 5, a first motor 5 for driving the first rotary cylinder 1 to rotate at a first rotation speed is connected with the first rotary cylinder 1 and is positioned below the conical screen cylinder 4,
a crushing unit 6, the crushing unit 6 for crushing raw materials is arranged in the first rotary cylinder 1, the crushing unit 6 is driven by a second motor 7 to rotate at an adjustable second rotating speed, the crushing unit 6 comprises a left inverted trapezoidal crushing body 8 and a right inverted trapezoidal crushing body 9, the left inverted trapezoidal crushing body 8 and the right inverted trapezoidal crushing body 9 are both matched with the conical screen cylinder 4, the left inverted trapezoidal crushing body 8 and/or the right inverted trapezoidal crushing body 9 are/is provided with a plurality of triangular grooves 10 which are gradually reduced from top to bottom, the outer surfaces of the left inverted trapezoidal crushing body 8 and/or the right inverted trapezoidal crushing body 9 and the triangular grooves 10 thereon are respectively provided with a crushing blade 11,
a grinding unit 12, a grinding unit 12 for receiving and grinding the powder of the raw material sieved through the conical sieve tube 4 is disposed below the conical sieve tube 4, said grinding unit 12 comprises a rotatable arc-shaped grinding body 13, a grinding hammer 14 and a spray head 15 for spraying a predetermined amount of adhesive, said grinding body 13 is driven to rotate at a third rotational speed by a third motor 16, said grinding hammer 14 is moved up and down at a linear speed by a telescopic cylinder 17, said grinding body 13 is provided with a discharge valve 18 for discharging the ground powder,
a particle forming unit 19, comprising:
the particle forming shell 20, the inner wall of which is provided with a plurality of upward-inclined undulations 21 arranged along the axial direction, said undulations 21 comprising arc-shaped protrusions 22 and arc-shaped grooves 23 adjoining each other,
a second rotating cylinder 24, the second rotating cylinder 24 being adjustably rotated at a fourth rotational speed within the particle-forming enclosure 20 via a second motor 16,
a feeding channel 25, the feeding channel 25 for sucking the powder to the particle forming unit 19 is connected with the discharge valve 18, a first fan 26 for generating gas carrier is arranged in the feeding channel 25, the powder is pressed by the second rotary cylinder 24 from bottom to top along the undulation structure 21 through the gas carrier to form granules,
a screen 27 disposed obliquely above the second rotary cylinder 24,
a second fan 28 which blows an air flow so that the granules smaller than the predetermined first particle diameter pass through the screen 27,
a circulation passage 29 for circulating the granules larger than a predetermined first particle diameter to the circulation passage 29 below the second rotary cylinder 24 with the lowermost end side of the screen 27,
the cyclone 30, the granules larger than the predetermined second particle size are discharged upward through the cyclone 30, and the granules smaller than the predetermined second particle size enter the circulation passage 29.
The granule forming device of the invention can accurately and continuously carry out large-scale industrial production in a full flow, the annular feed inlet 2 can uniformly and controllably input raw materials into the left inverted trapezoidal crushing body 8 and the right inverted trapezoidal crushing body 9 of the crushing unit, compared with a single feed inlet or a feed hopper in the prior art, the blanking uniformity is obviously improved, the crushing efficiency of the raw materials is improved, the crushing blades arranged on the outer surfaces of the left inverted trapezoidal crushing body 8 and/or the right inverted trapezoidal crushing body 9 and the triangular groove 10 on the left inverted trapezoidal crushing body and/or the right inverted trapezoidal crushing body can lead the raw materials to be crushed in multiple times in the falling process, from top to bottom, as the shape of the conical screen cylinder is matched, the space is smaller downwards, the crushing effect is gradually improved, on the basis that the first rotary cylinder body and the crushing unit rotate oppositely and rotate differently, the conical screen cylinder 4 can repeatedly eject the raw materials which are not sieved to the crushing unit, further, multiple crushing is always performed through the crushing blades arranged on the triangular grooves, compared with the prior art, the crushing effect of the crushing unit is remarkably improved, the rotary grinding body and the grinding hammer in linear motion are uniformly mixed with the adhesive and the powder to be fully ground, the uniformity of particles and the uniformity of particle size are further improved, the third motor drives the grinding body and the second rotary cylinder 24 simultaneously, the structure is simplified, the cost is saved, the powder moves from bottom to top along the fluctuation structure 21 through the gas carrier, the ground powder containing the adhesive is extruded into the particles through the arc-shaped protrusions 22 and the arc-shaped grooves 23 which are adjacent to each other, the arc-shaped protrusions 22 and the arc-shaped grooves 23 in the plurality of upward inclination fluctuation structures form a spiral upward extrusion channel, the particles with high uniformity can be stably and efficiently formed, the second fan 28 blows air flow to enable the particles smaller than the preset first particle size to pass through the filter screen 27, the inclined arrangement of the filter screen 27 improves the screening efficiency, granules passing through the filter screen are easily input into the cyclone separator, granules which do not meet the conditions just fall on the inlet of the circulating channel, granules which are larger than the preset second particle size are upwards discharged through the cyclone separator 30, the particle size consistency of the formed granules is ensured, the circulating channel 29 recycles and extrudes the granules which do not meet the conditions, and the cost is saved.
In the preferred embodiment of the granule forming apparatus according to the present invention, the annular feed inlet 2 is connected to a solenoid valve for controlling the feeding speed and the feeding amount, and the grinding body 13 is connected to the third motor 16 via a decelerator. The invention can ensure the crushing effect by controlling the feeding speed and the feeding amount through the electromagnetic valve.
In a preferred embodiment of the granule forming apparatus according to the present invention, the horizontal portion of the conical sieve drum 14 at the lowermost end of the left inverted trapezoidal crushing body 8 and/or the right inverted trapezoidal crushing body 9 is provided with a stirring blade for stirring, and the left inverted trapezoidal crushing body 8 and the right inverted trapezoidal crushing body 9 are bilaterally symmetrical. The raw materials which are not sieved are stirred and rolled through the stirring blades, and are reflected to the crushing unit through the conical sieve barrel to be crushed again through the reverse rotation, so that the crushing efficiency is further improved.
In a preferred embodiment of the granule forming apparatus according to the present invention, the granule forming apparatus includes a liquid crystal touch panel and a frequency converter for regulation, the frequency converter is electrically connected to the first and second fans, the nozzle, and/or the first to third motors, and the arc-shaped protrusions 22 and the arc-shaped grooves 23 in the plurality of upward inclined undulating structures form a spirally upward extrusion channel. According to the invention, the frequency converter is used for uniformly and coordinately controlling the components, so that the control precision and the coordination can be improved, and the formed extrusion channel can improve the particle forming efficiency.
In a preferred embodiment of the granule forming apparatus according to the present invention, the first rotational speed is opposite to the second to fourth rotational speeds, and the speeds are, in order from the largest to the smallest, the fourth rotational speed, the second rotational speed, the third rotational speed, and the first rotational speed. The relationship between the speed and the direction ensures the particle forming quality of the invention and saves energy consumption.
In a preferred embodiment of the granule forming apparatus according to the present invention, the granule forming apparatus comprises a control device for controlling the process, the control device is wirelessly connected to the first and second fans, the spray head, and/or the first to third motors via a wireless communication device, the control device comprises a digital signal processor, an application specific integrated circuit ASIC, or a field programmable gate array FPGA, the control device comprises a memory, and the memory may comprise one or more of a read only memory ROM, a random access memory RAM, a flash memory, or an electrically erasable programmable read only memory EEPROM. The invention can automatically control the forming process and optimize each parameter through the control device in wireless connection.
In a preferred embodiment of the granule forming apparatus of the present invention, the control device is a mobile phone, a pad, or a cloud server.
In a preferred embodiment of the granule forming apparatus of the present invention, the wireless communication device at least includes a wireless local area network communication device and/or a mobile communication network device, the mobile communication network device includes a 2G/3G/4G wireless communication chip, and the wireless local area network communication device includes one of a bluetooth module, a ZigBee module, or a Wi-Fi module.
Fig. 2 is a schematic view of the steps of the forming method using the granule forming apparatus according to the present invention. The forming method by using the granular agent forming device comprises the following steps:
a first step S1 of controllably feeding a predetermined amount of raw material of granules from the ring-shaped feed port 2, the first rotary cylinder 1 rotating at a first rotational speed, the crushing unit 6 rotating at a second rotational speed opposite to the first rotational speed, the left and/or right inverted trapezoidal crushing bodies 8 and 9 and the crushing blades 11 on the outer surfaces of the triangular grooves 10 thereon crushing the raw material multiple times to form powder,
in a second step S2, the spray head 15 sprays a predetermined amount of adhesive, the grinding body 13 is driven to rotate at a third rotational speed opposite to the first rotational speed by the third motor 16, the grinding hammer 14 moves up and down at a linear speed to grind the adhesive-laden powder by the retractable cylinder 17,
in a third step S3, the powder is transported from the discharge valve 18 to the particle formation unit 19 via the gas carrier, the second rotary cylinder 24 is adjustably rotated at a fourth rotation speed in the particle formation casing 20, the powder is pressed by the second rotary cylinder 24 from bottom to top along the undulation structure 21 to form granules, the second fan 28 blows the air flow so that the granules smaller than the predetermined first particle size pass through the screen 27, the granules larger than the predetermined second particle size are discharged upward via the cyclone 30 as qualified granules, and the granules larger than the predetermined first particle size are circulated to the circulation passage 29 under the second rotary cylinder to be pressed again.
A granule is formed by the forming method. The granule of the invention has high content uniformity and good particle size consistency.
Industrial applicability
The granule forming apparatus, the granule forming method and the granules of the present invention can be manufactured and used in the field of pharmaceutical preparations.
Although the embodiments of the present invention have been described above with reference to the accompanying drawings, the present invention is not limited to the above-described embodiments and application fields, and the above-described embodiments are illustrative, instructive, and not restrictive. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope of the invention as defined by the appended claims.
Claims (9)
1. A granule forming apparatus, characterized by comprising,
a first rotary cylinder body (1) which comprises an annular feed inlet (2) arranged at the top for controllably feeding raw materials of granules, a closed outer cylinder wall (3) and a conical screen cylinder (4) arranged at the bottom for screening,
a first motor (5) for driving the first rotary cylinder (1) to rotate at a first rotation speed, wherein the first motor (5) is connected with the first rotary cylinder (1) and is positioned below the conical screen cylinder (4),
the crushing unit (6) is used for crushing the raw materials and is arranged in the first rotary cylinder body (1), the crushing unit (6) is driven by a second motor (7) to rotate at an adjustable second rotating speed, the crushing unit (6) comprises a left inverted trapezoidal crushing body (8) and a right inverted trapezoidal crushing body (9), the left inverted trapezoidal crushing body (8) and the right inverted trapezoidal crushing body (9) are both matched with the conical screen cylinder (4) and are arranged, the left inverted trapezoidal crushing body (8) and/or the right inverted trapezoidal crushing body (9) are provided with a plurality of triangular grooves (10) which are gradually reduced from top to bottom, and the outer surfaces of the left inverted trapezoidal crushing body (8) and/or the right inverted trapezoidal crushing body (9) and the triangular grooves (10) on the left inverted trapezoidal crushing body (8) and/or the right inverted trapezoidal crushing body (9) are respectively provided with crushing blades (11),
a grinding unit (12), a grinding unit (12) for receiving and grinding the powder of the raw material sieved through the conical sieve cylinder (4) is arranged below the conical sieve cylinder (4), the grinding unit (12) comprises a rotatable arc-shaped grinding body (13), a grinding hammer (14) and a spray head (15) for spraying a predetermined amount of adhesive, the grinding body (13) is driven to rotate at a third rotational speed through a third motor (16), the grinding hammer (14) moves up and down at a linear speed through a telescopic cylinder (17), the grinding body (13) is provided with a discharge valve (18) for discharging the ground powder,
a particle forming unit (19) comprising:
a particle-forming envelope (20) whose inner wall is provided with a plurality of axially aligned, obliquely upward undulations (21), said undulations (21) comprising arcuate projections (22) and arcuate recesses (23) that adjoin one another,
a second rotary drum (24), the second rotary drum (24) being adjustably rotated at a fourth rotational speed in the particle forming enclosure (20) via a second motor (16),
a feed channel (25), the feed channel (25) for sucking the powder to the particle forming unit (19) is connected with the discharge valve (18), a first fan (26) for generating gas carrier is arranged in the feed channel (25), the powder is pressed by the second rotary cylinder (24) from bottom to top along the fluctuation structure (21) through the gas carrier to form granules,
a screen (27) disposed obliquely above the second rotary cylinder (24),
a second fan (28) that blows an air flow so that the granular agent smaller than the predetermined first particle diameter passes through the screen (27),
a circulating channel (29) for circulating granules with a particle size larger than a predetermined first particle size to the side of the lowest end of the circulating channel (29) below the second rotary cylinder (24) provided with a filter screen (27),
the grinding body (13) is connected with a third motor (16) through a speed reducer, arc-shaped protrusions (22) and arc-shaped grooves (23) in a plurality of inclined upward fluctuating structures form a spiral upward extrusion channel, and a stirring blade for stirring is arranged on a horizontal part of a conical screen cylinder (4) at the lowest end of the left inverted trapezoidal crushing body (8) and/or the right inverted trapezoidal crushing body (9) relatively.
2. The granule forming apparatus according to claim 1, characterized in that: the left inverted trapezoidal crushing body (8) and the right inverted trapezoidal crushing body (9) are bilaterally symmetrical.
3. The granule forming apparatus according to claim 1, characterized in that: granule forming device includes liquid crystal touch-sensitive screen and is used for the converter of regulation and control, the converter electricity is connected first and second fan, shower nozzle, and/or first to third motor.
4. The granule forming apparatus according to claim 1, characterized in that: the direction of the first rotating speed is opposite to the direction of the second rotating speed to the fourth rotating speed, and the speeds are the fourth rotating speed, the second rotating speed, the third rotating speed and the first rotating speed from large to small in sequence.
5. The granule forming apparatus according to claim 1, characterized in that: the granule forming device comprises a control device for controlling the process, the control device is in wireless connection with the first fan, the second fan, the spray head and/or the first motor, the second fan, the spray head and/or the third motor through a wireless communication device, the control device comprises a digital signal processor, an Application Specific Integrated Circuit (ASIC) or a Field Programmable Gate Array (FPGA), and the control device comprises a memory, wherein the memory comprises one or more of a Read Only Memory (ROM), a Random Access Memory (RAM), a flash memory or an Electrically Erasable Programmable Read Only Memory (EEPROM).
6. The granule forming apparatus according to claim 5, characterized in that: the control device is a mobile phone, a pad or a cloud server.
7. The granule forming apparatus according to claim 5, characterized in that: the wireless communication equipment at least comprises wireless local area network communication equipment and/or mobile communication network equipment, the mobile communication network equipment comprises a 2G/3G/4G wireless communication chip, and the wireless local area network communication equipment comprises one of a Bluetooth module, a ZigBee module or a Wi-Fi module.
8. A forming method using the granule forming apparatus according to any one of claims 1 to 7, comprising the steps of:
a first step (S1) of controllably feeding a predetermined amount of raw material for granules from the ring-shaped feed port (2), the first rotary cylinder (1) being rotated at a first rotational speed, the crushing unit (6) being rotated at a second rotational speed opposite to the first rotational speed, the left inverted trapezoidal crushing body (8) and/or the right inverted trapezoidal crushing body (9) and the crushing blades (11) on the outer surface of the triangular grooves (10) thereon crushing the raw material multiple times to form powder,
a second step (S2) of spraying a predetermined amount of the adhesive from the spray head (15), rotating the grinding body (13) at a third rotational speed opposite to the first rotational speed by driving via a third motor (16), moving up and down the grinding hammer (14) at a linear speed via a telescopic cylinder (17) to grind the powder with the adhesive,
and a third step (S3) of conveying the powder from the discharge valve (18) to a particle forming unit (19) through a gas carrier, adjustably rotating a second rotary cylinder (24) in a particle forming shell (20) at a fourth rotation speed, pressing the powder by the second rotary cylinder (24) along a relief structure (21) from bottom to top to form granules, blowing air by a second fan (28) to enable the granules smaller than the preset first particle size to pass through a filter screen (27), discharging the granules larger than the preset second particle size upwards through a cyclone separator (30) to form qualified granules, and circulating the granules larger than the preset first particle size to a circulating channel (29) below the second rotary cylinder for re-pressing.
9. A granule formed by the forming method of claim 8.
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