CN108883081A - 蛋白酶体抑制剂治疗眼部疾病的用途 - Google Patents
蛋白酶体抑制剂治疗眼部疾病的用途 Download PDFInfo
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- UIERETOOQGIECD-ONEGZZNKSA-N tiglic acid Chemical compound C\C=C(/C)C(O)=O UIERETOOQGIECD-ONEGZZNKSA-N 0.000 description 1
- UAXOELSVPTZZQG-UHFFFAOYSA-N tiglic acid Natural products CC(C)=C(C)C(O)=O UAXOELSVPTZZQG-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 229940125379 topical corticosteroid Drugs 0.000 description 1
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- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562251937P | 2015-11-06 | 2015-11-06 | |
| US62/251,937 | 2015-11-06 | ||
| PCT/US2016/058402 WO2017078953A1 (en) | 2015-11-06 | 2016-10-24 | Use of proteasome inhibitors to treat ocular disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108883081A true CN108883081A (zh) | 2018-11-23 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201680077578.4A Pending CN108883081A (zh) | 2015-11-06 | 2016-10-24 | 蛋白酶体抑制剂治疗眼部疾病的用途 |
Country Status (8)
| Country | Link |
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| US (1) | US20180325854A1 (https=) |
| EP (1) | EP3370709A4 (https=) |
| JP (1) | JP2018533629A (https=) |
| CN (1) | CN108883081A (https=) |
| AU (1) | AU2016349833A1 (https=) |
| CA (1) | CA3004587A1 (https=) |
| IL (1) | IL259153A (https=) |
| WO (1) | WO2017078953A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3746114B1 (en) | 2018-01-30 | 2022-05-04 | Universiteit Gent | Compositions for use to treat cataract |
| CA3120453A1 (en) * | 2018-12-10 | 2020-06-18 | EternaTear, Inc. | Ophthalmic formulations providing durable ocular lubrication |
| CN110840860B (zh) * | 2019-11-22 | 2021-12-31 | 国家纳米科学中心 | 一种纳米药物及其制备方法和应用 |
| US12594351B2 (en) * | 2021-08-04 | 2026-04-07 | Harrow Ip Llc | Methods for increasing shelf-life of ophthalmic pharmaceutical compositions |
| US11679078B1 (en) | 2022-03-08 | 2023-06-20 | EternaTear, Inc. | Ophthalmic formulations and related methods |
| US11471475B1 (en) | 2022-03-08 | 2022-10-18 | Ralph P. Stone | Ophthalmic suspension vehicles and related methods for pharmaceutical ingredient delivery |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2456990C2 (ru) * | 2006-09-15 | 2012-07-27 | Янссен Фармацевтика Нв | Комбинации специфичных ингибиторов гистоновых деацетилаз класса i с ингибиторами протеасом |
| US8722724B2 (en) * | 2004-12-03 | 2014-05-13 | Triphase Research And Development I Corp. | Compositions and methods for treating neoplastic diseases |
| US8809283B2 (en) * | 2005-05-20 | 2014-08-19 | Natuderm, Llc | Proteasome inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770115A (en) * | 1996-04-19 | 1998-06-23 | Ppg Industries, Inc. | Photochromic naphthopyran compositions of improved fatigue resistance |
| AU756000B2 (en) * | 1998-04-02 | 2003-01-02 | Novartis Ag | Method for stabilizing pharmaceutical compositions by special use of an antioxidant |
| CN101346136A (zh) * | 2005-10-24 | 2009-01-14 | 西巴控股公司 | 可氧化剂的保护 |
| EP2471507B1 (en) * | 2006-09-29 | 2017-03-01 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices used in the treatment of ocular allergies |
| EP2127638A1 (en) * | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| CN103566049B (zh) * | 2012-08-08 | 2017-08-04 | 浙江医药股份有限公司新昌制药厂 | 用于提高眼睛中视黄斑色素密度并预防或治疗年龄相关性视黄斑衰退症的组合物 |
-
2016
- 2016-10-24 JP JP2018544025A patent/JP2018533629A/ja active Pending
- 2016-10-24 CA CA3004587A patent/CA3004587A1/en not_active Abandoned
- 2016-10-24 WO PCT/US2016/058402 patent/WO2017078953A1/en not_active Ceased
- 2016-10-24 AU AU2016349833A patent/AU2016349833A1/en not_active Abandoned
- 2016-10-24 CN CN201680077578.4A patent/CN108883081A/zh active Pending
- 2016-10-24 US US15/773,920 patent/US20180325854A1/en not_active Abandoned
- 2016-10-24 EP EP16862704.0A patent/EP3370709A4/en not_active Withdrawn
-
2018
- 2018-05-06 IL IL259153A patent/IL259153A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8722724B2 (en) * | 2004-12-03 | 2014-05-13 | Triphase Research And Development I Corp. | Compositions and methods for treating neoplastic diseases |
| US8809283B2 (en) * | 2005-05-20 | 2014-08-19 | Natuderm, Llc | Proteasome inhibitors and uses thereof |
| RU2456990C2 (ru) * | 2006-09-15 | 2012-07-27 | Янссен Фармацевтика Нв | Комбинации специфичных ингибиторов гистоновых деацетилаз класса i с ингибиторами протеасом |
Non-Patent Citations (3)
| Title |
|---|
| MU-HSIN CHEN等: "Epigallocatechin gallate eye drops protect against ultraviolet B-induced corneal oxidative damage in mice", 《MOLECULAR VISION》 * |
| SCHEINFELD等: "A review of deferasirox, bortezomib, dasatinib, and cyclosporine eye drops: possible uses and known side effects in cutaneous medicine.", 《JOURNAL OF DRUGS IN DERMATOLOGY》 * |
| SHENG-MIN HSU: "Proteasome Inhibitor Bortezomib Suppresses Nuclear Factor-Kappa B Activation and Ameliorates Eye Inflammation in Experimental Autoimmune Uveitis", 《MEDIATORS OF INFLAMMATION》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3370709A1 (en) | 2018-09-12 |
| IL259153A (en) | 2018-06-28 |
| AU2016349833A1 (en) | 2018-05-24 |
| JP2018533629A (ja) | 2018-11-15 |
| US20180325854A1 (en) | 2018-11-15 |
| EP3370709A4 (en) | 2019-12-18 |
| CA3004587A1 (en) | 2017-05-11 |
| WO2017078953A1 (en) | 2017-05-11 |
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Application publication date: 20181123 |