CN108883081A - 蛋白酶体抑制剂治疗眼部疾病的用途 - Google Patents

蛋白酶体抑制剂治疗眼部疾病的用途 Download PDF

Info

Publication number
CN108883081A
CN108883081A CN201680077578.4A CN201680077578A CN108883081A CN 108883081 A CN108883081 A CN 108883081A CN 201680077578 A CN201680077578 A CN 201680077578A CN 108883081 A CN108883081 A CN 108883081A
Authority
CN
China
Prior art keywords
group
composition
eye
proteasome inhibitor
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680077578.4A
Other languages
English (en)
Chinese (zh)
Inventor
里克·库隆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaceutical Co Ltd
Original Assignee
Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaceutical Co Ltd filed Critical Pharmaceutical Co Ltd
Publication of CN108883081A publication Critical patent/CN108883081A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680077578.4A 2015-11-06 2016-10-24 蛋白酶体抑制剂治疗眼部疾病的用途 Pending CN108883081A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562251937P 2015-11-06 2015-11-06
US62/251,937 2015-11-06
PCT/US2016/058402 WO2017078953A1 (en) 2015-11-06 2016-10-24 Use of proteasome inhibitors to treat ocular disorders

Publications (1)

Publication Number Publication Date
CN108883081A true CN108883081A (zh) 2018-11-23

Family

ID=58662653

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680077578.4A Pending CN108883081A (zh) 2015-11-06 2016-10-24 蛋白酶体抑制剂治疗眼部疾病的用途

Country Status (8)

Country Link
US (1) US20180325854A1 (https=)
EP (1) EP3370709A4 (https=)
JP (1) JP2018533629A (https=)
CN (1) CN108883081A (https=)
AU (1) AU2016349833A1 (https=)
CA (1) CA3004587A1 (https=)
IL (1) IL259153A (https=)
WO (1) WO2017078953A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3746114B1 (en) 2018-01-30 2022-05-04 Universiteit Gent Compositions for use to treat cataract
CA3120453A1 (en) * 2018-12-10 2020-06-18 EternaTear, Inc. Ophthalmic formulations providing durable ocular lubrication
CN110840860B (zh) * 2019-11-22 2021-12-31 国家纳米科学中心 一种纳米药物及其制备方法和应用
US12594351B2 (en) * 2021-08-04 2026-04-07 Harrow Ip Llc Methods for increasing shelf-life of ophthalmic pharmaceutical compositions
US11679078B1 (en) 2022-03-08 2023-06-20 EternaTear, Inc. Ophthalmic formulations and related methods
US11471475B1 (en) 2022-03-08 2022-10-18 Ralph P. Stone Ophthalmic suspension vehicles and related methods for pharmaceutical ingredient delivery

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2456990C2 (ru) * 2006-09-15 2012-07-27 Янссен Фармацевтика Нв Комбинации специфичных ингибиторов гистоновых деацетилаз класса i с ингибиторами протеасом
US8722724B2 (en) * 2004-12-03 2014-05-13 Triphase Research And Development I Corp. Compositions and methods for treating neoplastic diseases
US8809283B2 (en) * 2005-05-20 2014-08-19 Natuderm, Llc Proteasome inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770115A (en) * 1996-04-19 1998-06-23 Ppg Industries, Inc. Photochromic naphthopyran compositions of improved fatigue resistance
AU756000B2 (en) * 1998-04-02 2003-01-02 Novartis Ag Method for stabilizing pharmaceutical compositions by special use of an antioxidant
CN101346136A (zh) * 2005-10-24 2009-01-14 西巴控股公司 可氧化剂的保护
EP2471507B1 (en) * 2006-09-29 2017-03-01 Johnson & Johnson Vision Care, Inc. Ophthalmic devices used in the treatment of ocular allergies
EP2127638A1 (en) * 2008-05-30 2009-12-02 Santen Pharmaceutical Co., Ltd Method and composition for treating ocular hypertension and glaucoma
CN103566049B (zh) * 2012-08-08 2017-08-04 浙江医药股份有限公司新昌制药厂 用于提高眼睛中视黄斑色素密度并预防或治疗年龄相关性视黄斑衰退症的组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8722724B2 (en) * 2004-12-03 2014-05-13 Triphase Research And Development I Corp. Compositions and methods for treating neoplastic diseases
US8809283B2 (en) * 2005-05-20 2014-08-19 Natuderm, Llc Proteasome inhibitors and uses thereof
RU2456990C2 (ru) * 2006-09-15 2012-07-27 Янссен Фармацевтика Нв Комбинации специфичных ингибиторов гистоновых деацетилаз класса i с ингибиторами протеасом

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MU-HSIN CHEN等: "Epigallocatechin gallate eye drops protect against ultraviolet B-induced corneal oxidative damage in mice", 《MOLECULAR VISION》 *
SCHEINFELD等: "A review of deferasirox, bortezomib, dasatinib, and cyclosporine eye drops: possible uses and known side effects in cutaneous medicine.", 《JOURNAL OF DRUGS IN DERMATOLOGY》 *
SHENG-MIN HSU: "Proteasome Inhibitor Bortezomib Suppresses Nuclear Factor-Kappa B Activation and Ameliorates Eye Inflammation in Experimental Autoimmune Uveitis", 《MEDIATORS OF INFLAMMATION》 *

Also Published As

Publication number Publication date
EP3370709A1 (en) 2018-09-12
IL259153A (en) 2018-06-28
AU2016349833A1 (en) 2018-05-24
JP2018533629A (ja) 2018-11-15
US20180325854A1 (en) 2018-11-15
EP3370709A4 (en) 2019-12-18
CA3004587A1 (en) 2017-05-11
WO2017078953A1 (en) 2017-05-11

Similar Documents

Publication Publication Date Title
JP5696121B2 (ja) α−2アドレナリン受容体アゴニスト含有生分解性眼内インプラント
CN108883081A (zh) 蛋白酶体抑制剂治疗眼部疾病的用途
CN105377285B (zh) 通过血管紧缩素肽的加速的眼睛损伤的治愈
CN109996814B (zh) 多激酶抑制剂及在眼部纤维化中的用途
CA2978874C (en) Ocular formulations comprising a glycosaminoglycan and an anesthetic
AU777655B2 (en) Ophthalmic histamine compositions and uses thereof
US10973758B2 (en) Methods of eye treatment using therapeutic compositions containing dipyridamole
El-Agha et al. Comparison of photorefractive keratectomy and laser in situ keratomileusis for the treatment of compound hyperopic astigmatism
US20070048338A1 (en) Compositions and methods for surface treatment in medical and surgical procedures
WO2014066653A1 (en) Ketorolac-containing sustained release intraocular drug delivery systems
EP3576799A1 (en) Ophthalmic compositions for therapeutic and prophylactic uses
Pérez-Sarriegui et al. Phaco-non-penetrating deep sclerectomy in ocular hypertension secondary to dexamethasone intravitreal implant
Quaranta et al. Endophthalmitis after compression sutures for enlarged conjunctival filtration bleb following trabeculectomy
Szaflik et al. Guidelines for perioperative care in cataract surgery in Poland
WO2026003055A1 (en) Ophthalmic composition for use for the prevention and treatment of eye infection and inflammation
WO2025090106A1 (en) Compositions and methods for treating neural degeneration in glaucoma and related conditions
CA2813734A1 (en) Use of rifalazil and analogues thereof to treat ocular disorders
US20160235765A1 (en) Methods of Managing Eye Pain and Compositions Related Thereto

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20181123