CN108853484A - A method of induction replacement gilt estrus synchronization - Google Patents
A method of induction replacement gilt estrus synchronization Download PDFInfo
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- CN108853484A CN108853484A CN201810813305.2A CN201810813305A CN108853484A CN 108853484 A CN108853484 A CN 108853484A CN 201810813305 A CN201810813305 A CN 201810813305A CN 108853484 A CN108853484 A CN 108853484A
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- replacement gilt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Abstract
A method of induction replacement gilt estrus synchronization, belong to animal estrus induction and artificial insemination field, the present invention is difficult to synchronous problem for replacement gilt heat, provide a kind of method for inducing replacement gilt estrus synchronization, by giving replacement gilt feeding Altrenogest before the deadline, it is injected intravenously eCG and hCG in conjunction in the set time, so that replacement gilt can estrus synchronization within the predetermined time.The present invention is conducive to the production of scale sow.
Description
Technical field
The present invention relates to animal estrus inductions and artificial insemination field, more specifically belong to livestock-raising technical field,
It is related to a kind of processing method for inducing sow estrus synchronization.
Background technique
Synchronization of Estrus is one of the important Reproductive manipulation technology in modern farming enterprise's production, it is to utilize certain hormone systems
Agent artificially controls and adjusts the oestrous cycle of a group dam, them is made to concentrate heat, concentration breeding, concentrate gestation, concentrate and divide
Childbirth is conducive to tissue production and management.In addition, synchronization of Estrus also helps the further genralrlization of technology of artificial insemination, together
When be also embryo transfer work important link.Synchronization of Estrus has been widely used in reproduction of domesti animals, and has obtained certain
Effect.Further research will provide theoretical and technical support for production application for this experiment.
The cyclostage phenomenon that sexually matured female mammal is showed in particular season is physiologically showing as ovulating,
Prepare fertilization and pregnancy, show as attracting in behavior and receives anisotropic.The drug of estrus synchronization is mainly by exogenous hormone
Ovary is stimulated, so that it is changed according to scheduled requirement, makes the ovarian physiology function for handling dam all in same phase, from
And reach estrus synchronization.
Estrus synchronization generallys use two kinds of approach.A kind of approach is to extend luteal phase, is administered simultaneously and pregnant swashs to a group dam
Plain drug inhibits the growth and development and heat performance of ovarian follicle.It after the drug treatment of regular period, is discontinued simultaneously, due to ovum
Nest loses the control of exogenous progestational hormone simultaneously, and the period corpus luteum on ovary has been degenerated, and then follicular development occurs simultaneously, causes
Dam heat.Dam heat is inhibited using progestational hormone, actually artificially extends luteal phase, is played and is extended the oestrous cycle, pushes away
The effect in slow oestrus.Another way is to shorten luteal phase, using acceleration luteolysis.Get rid of ovary in advance pregnant sharp in vivo
The control of element, then ovarian follicle is able to start simultaneously at development, to reach dam estrus synchronization.Such case is actually to shorten mother
The oestrous cycle of poultry promotes dam heat in a short time.The hormonal properties that two kinds of approach use are different, but are all to corpus luteum function
It can play regulatory role, so that luteal phase is extended or is shortened, finally reach the purpose for adjusting ovarian function.
But there are a series of problems for replacement gilt synchronization of Estrus at present.
1. due to the asynchronism of standby pig heat, the timing semen deposition of large-scale can not be carried out to pig, this be by
The great waste of labour.
2. the method for the induction synchronization of estrus that everybody uses at present is very more, especially some of which drug is on the market
Few or dependence import, this virtually increases the cost of pig cultivation and can not accomplish to cultivate on a large scale.
3. the feed mode of the progesterone analog in big multi-method is incorporated into daily feed at present, due to others
Drug has peculiar smell, and pig is caused to be reluctant to search for food, and drug is caused not searched for food by pig all, due to pig feeding drug measurer
There is great variation, causes the heat in later period that can not synchronize.
Summary of the invention
It is difficult to synchronous problem for standby pig heat, the present invention provides a kind of induction replacement gilt estrus synchronizations
Method, this method just for standby pig, by regular time and quantity give corresponding drug, to induce the pig of processing pre-
Fixed time synchronization heat, to be conducive to large-scale pig breeding cultivation.
The sow of this method processing necessarily requires health disease-free, cannot especially carry the relevant disease of breeding, age in days
At -230 days 220 days, weight 130kg-140kg, the growth of livestock was medium.There are three types of the drugs that this method uses：Altrenogest, hCG
And eCG.Altrenogest is a kind of progesterone analog, has and extends luteal phase, the growth and development for inhibiting ovarian follicle and heat performance.
It is discontinued simultaneously after the processing of regular period, since ovary loses the control of exogenous progestational hormone simultaneously, the period on ovary
Corpus luteum has been degenerated, and then follicular development occurs simultaneously, so as to cause dam heat.HCG injection is amcinonide, is being injected
Afterwards, can promote animal anterior pituitary discharge follicle-stimulating hormone FSH and LH, and then cause blood plasma LH apparent increase and FSH it is light
Degree increases, and the oocyte maturation of female ovarium is promoted to ovulate.There is injection eCG follicle-stimulating hormone and luteotropin sample to make
With, the maturation of ovarian follicle, the generation of ovulation and corpus luteum can promote to dam, and stimulate corpus luteum secrete progestational hormone.
The method of induction sow estrus synchronization of the present invention, every pig pinpoint feeding Altrenogest, continuous feeding daily
After 18-20 days, after being spaced 42-48h, every pig injects horse human chorionic gonadtropin eCG, then after being spaced 80-85 hours, every head
Pig injects human chorionic gonadotrophin hCG, and interval is after 24 hours, the equal heat of pig.The mark of the heat is with stabilization
The mounting for receiving boar or other pigs is heat main feature, also include some appetite be remarkably decreased, when from when crouch, climb wall, arch
The behaviors such as ground, hurdle race.Most important, underwent operative method confirms the pig of estrus induction, and ovary has ovulated and corpus hemorrhagicum occurred.
Preferably, the number of days of the continuous feeding Altrenogest of every pig is 18 days, after being spaced 42h, injection eCG, then between
After 80h, hCG is injected.
It further limits, the amount that every pig pinpoints feeding Altrenogest daily is 16-20mg.
It further limits, every pig injection eCG amount is 400IU.
It further limits, every pig injection hCG amount is 200IU.
It further limits, the replacement gilt age in days is -230 days 220 days, weight 130kg-140kg.
Further limit, artificial insemination carried out after pig heat, without returning feelings in 21 days, the pig of processing by
It is pregnant, into the gestational period.
Further limit, artificial insemination's number be twice, respectively after pig heat for 24 hours with 40h.
Beneficial effect
1. experiment medicament sources used are extensive, easy to use, be conducive to promote the use of on a large scale.
2. the liquid drug of Altrenogest in this method, colorless and odorless can directly be taken by pig with feeding rifle, avoid
The loss of dosage when waste and administration that drug is given.
3. treated pig, all in hCG treated whole heats on the same day, estrus induction it is high-efficient.
4. the present invention can improve receptor sow by with rate, conception rate, shorten the breeding season, reduce it is infertile, improve breed
Rate reduces manpower and material resources consumption, and is conducive to development of the technology of artificial insemination on pig, convenient for extensive tissue production and timing
The large scale experiment of property；Secondly, inducing estrus synchronization that can reduce sow in reproductive process in sow production batch management
In abnormality, bring huge economic benefit to pig farm, be conducive to save labour, be conducive to size of the organization metaplasia
It produces, is truly realized all-in and all-out, is conducive to that swinery is made to reach same reproductive status, health status and immune state.
5. the present invention facilitates the heat of the accurate and timing of embryo transplantation acceptor, be conducive to improve embryo transfer efficiency and
Success rate.
Detailed description of the invention
Fig. 1 embodiment 1 handles pig ovary ovulation situation.
Fig. 2 embodiment 2 handles pig ovary ovulation situation.
Fig. 3 embodiment 3 handles pig ovary ovulation situation.
Specific embodiment
The method of the induction replacement gilt estrus synchronization of embodiment 1..
It is disease-free to choose health, cannot especially carry the relevant disease of breeding, age in days at 220 days, weight in 130kg,
Medium replacement gilt 18 of the growth of livestock.
After having chosen pig, the time as defined in one, such as every afternoon 14:00 feeding 16mg Altrenogest, continues
18 days, most 20 days；Last time feed after be spaced 48 hours, the 20th day 14:00 injection 400IU eCG；It is small to be spaced 80
When；The 22 of 23rd day:00 injection 200IU hCG；The 22 of 24th day:00 pig starts heat.
Estrus synchronization detection：Opening operation abdomen inspection discovery ovary is carried out to the pig after the present embodiment induction to have ovulated,
There is corpus hemorrhagicum, as shown in Figure 1, pig Development of Reproductive System is good, the appearance without any lesion.The development of ovary of two sides is good,
And ovulated, there is corpus hemorrhagicum, (as shown in figure 1 shown in A) ovary corpus hemorrhagicum number is 11 on the left of pig, right side (B institute as shown in figure 1
Show) ovary corpus hemorrhagicum number be 3.
Artificial insemination：At the 25th day 22:The 13 of 00 and the 26th day:00, artificial insemination twice is carried out respectively, hereafter daily two
It is secondary to carry out looking into feelings, if not without returning feelings in 21 days, then it represents that processing pig successful pregnancies, into the gestational period, through looking into feelings,
All pigs successful pregnancies.
The method of the induction replacement gilt estrus synchronization of embodiment 2..
It is disease-free to choose health, cannot especially carry the relevant disease of breeding, age in days at 225 days, weight in 135kg,
Medium replacement gilt 18 of the growth of livestock.
After having chosen pig, the time as defined in one, such as every afternoon 14:00 feeding 18mg Altrenogest, continues
19 days；Last time feed after be spaced 45 hours, the 21st day 11:00 injection 400IU eCG；Interval 80 hours；24th day
19:00 injection 200IU hCG；The 19 of 24th day:00 pig starts heat.
Estrus synchronization detection：Opening operation abdomen inspection discovery ovary is carried out to the pig after the present embodiment induction to have ovulated,
There is corpus hemorrhagicum, as shown in Fig. 2, pig Development of Reproductive System is good, the appearance without any lesion.Wherein the development of ovary of two sides is good
It is good, and ovulated, there is corpus hemorrhagicum, (as shown in A in Fig. 2) ovary corpus hemorrhagicum number is 5 on the left of pig, right side (B in such as Fig. 2
It is shown) ovary corpus hemorrhagicum number be 7.
Artificial insemination：At the 25th day 19:The 11 of 00 and the 26th day:00, artificial insemination twice is carried out respectively, hereafter daily two
It is secondary to carry out looking into feelings, if not without returning feelings in 21 days after semen deposition, then it represents that processing pig successful pregnancies, into the gestational period,
Looked into feelings, all pigs successful pregnancies.
The method of the induction replacement gilt estrus synchronization of embodiment 3..
It is disease-free to choose health, cannot especially carry the relevant disease of breeding, age in days at 220 days, weight in 140kg,
Medium replacement gilt 18 of the growth of livestock.
After having chosen pig, the time as defined in one, such as every afternoon 14:00 feeding 20mg Altrenogest, continues
20 days；Last time feed after be spaced 42 hours, the 22nd day 6:00 injection 400IU eCG；Interval 80 hours；25th day
14:00 injection 200IU hCG；The 14 of 26th day:00 pig starts heat.
Estrus synchronization detection：Opening operation abdomen inspection discovery ovary is carried out to the pig after the present embodiment induction to have ovulated,
There is corpus hemorrhagicum, as shown in figure 3, pig 320, Development of Reproductive System is good, the appearance without any lesion.The wherein ovary hair of two sides
It educates well, and has ovulated, corpus hemorrhagicum occur, (as shown in A in fig. 3) ovary corpus hemorrhagicum number is 7 on the left of pig, right side (such as Fig. 3
Shown in middle B) ovary corpus hemorrhagicum number be 4.
Artificial insemination：At the 25th day 14:The 5 of 00 and the 26th day:00, artificial insemination twice is carried out respectively, hereafter daily two
It is secondary to carry out looking into feelings, if not without returning feelings in 21 days, then it represents that processing pig successful pregnancies, into the gestational period, through looking into feelings,
All pigs successful pregnancies.
Claims (9)
1. a kind of method for inducing replacement gilt estrus synchronization, which is characterized in that every pig pinpoints feeding Altrenogest daily, even
Continuous feeding is after 18-20 days, after being spaced 42-48h, every pig injection horse human chorionic gonadtropin eCG, then after being spaced 80-85h,
Every pig injects human chorionic gonadotrophin hCG, and interval is after 24 hours, the equal heat of pig.
2. the method for induction replacement gilt estrus synchronization according to claim 1, which is characterized in that every pig is continuous
The number of days of feeding Altrenogest is 18 days, after being spaced 42h, injects eCG, then after being spaced 80h, injects hCG.
3. the method for induction replacement gilt estrus synchronization according to claim 1 or 2, which is characterized in that every pig
The amount of fixed point feeding Altrenogest is 16-20mg daily.
4. the method for induction replacement gilt estrus synchronization according to claim 1 or 2, which is characterized in that every pig
Injection eCG amount is 400IU.
5. the method for induction replacement gilt estrus synchronization according to claim 1 or 2, which is characterized in that every pig
Injection hCG amount is 200IU.
6. the method for induction replacement gilt estrus synchronization according to claim 1 or 2, which is characterized in that the standby is female
Pig age in days is -230 days 220 days, weight 130kg-140kg.
7. the method for induction replacement gilt estrus synchronization according to claim 1 or 2, which is characterized in that the heat
Pig ovary has been ovulated, and corpus hemorrhagicum occurs.
8. the method for induction replacement gilt estrus synchronization according to claim 1 or 2, which is characterized in that in pig heat
After carry out artificial insemination, without returning feelings in 21 days, the pig of processing is become pregnant, into the gestational period.
9. the method for induction replacement gilt estrus synchronization according to claim 8, which is characterized in that the artificial insemination time
Number for twice, respectively after pig heat for 24 hours with 40h.
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| CN201810813305.2A CN108853484B (en) | 2018-07-23 | 2018-07-23 | Method for inducing replacement gilts to estrus synchronously |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110199951A (en) * | 2019-07-08 | 2019-09-06 | 武汉维尔鑫动物种质资源开发有限公司 | A method of clone pig batch production is realized with drug estrus synchronization |
| CN111134084A (en) * | 2020-01-06 | 2020-05-12 | 浙江省农业科学院 | Method for optimizing timing insemination effect of replacement gilts |
| CN112089503A (en) * | 2020-09-29 | 2020-12-18 | 湖北省农业科学院畜牧兽医研究所 | Method for in vitro cloning of embryo transplantation surrogate pregnant sow |
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| WO2010085363A1 (en) * | 2009-01-26 | 2010-07-29 | Hal Witt | Estrus synchronization preparations and effective cidr-less protocols |
| CN104994865A (en) * | 2012-11-28 | 2015-10-21 | 杰碧斯联合动物健康第二有限责任公司 | Method for synchronizing time of insemination in gilts |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110199951A (en) * | 2019-07-08 | 2019-09-06 | 武汉维尔鑫动物种质资源开发有限公司 | A method of clone pig batch production is realized with drug estrus synchronization |
| CN111134084A (en) * | 2020-01-06 | 2020-05-12 | 浙江省农业科学院 | Method for optimizing timing insemination effect of replacement gilts |
| CN112089503A (en) * | 2020-09-29 | 2020-12-18 | 湖北省农业科学院畜牧兽医研究所 | Method for in vitro cloning of embryo transplantation surrogate pregnant sow |
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| CN108853484B (en) | 2021-08-17 |
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