CN108853481A - For regenerated composition of cell-stimulating and its preparation method and application - Google Patents
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Abstract
The present invention relates to for regenerated composition of cell-stimulating and its preparation method and application, wherein the Chinese medicine composition includes the raw material that following weight crushes：20 parts~40 parts of GG hEGF, 5 parts~22 parts of vascular endothelial growth factor, 2 parts~12 parts of platelet derived growth factor, desmocyte growth factor-21 part~10 part, 20 parts~30 parts of Chinese gall, 2 parts~10 parts of Radix Glycyrrhizae and 3 parts~8 parts of Asian puccoon.Of the invention is used for the regenerated composition of cell-stimulating, can activate body, Facial Depression and relaxation skin, increase skin elasticity, reach competent cell state, additionally it is possible to promote reepithelialization and generate collagen, repair epithelial cell, promote angiogenic growth, can also dissipate extravasated blood, improve oily skin and pale skin quality, and break up the skin cell proliferation of aging, accelerate fibroblastic generation, the elastic fibers and collagenous fibres of fracture are repaired, skin histology is improved, inhibits scar hyperplasia.
Description
Technical field
The present invention relates to one kind for regenerated composition of cell-stimulating and its preparation method and application.
Background technique
Human body is got up by cell tissue, forms the chemical substance of cell during exercise constantly by the shadow of internal and external environment
It rings and damages, function degeneration is caused to decline and aging.The aging and death of cell will result in recess relaxation.Study table
Bright, nucleus, cytoplasm and cell membrane of senile cell etc. change significantly：1. intracellular water is reduced, volume becomes smaller,
Rate of metabolism slows down；2. the activity of desmoenzyme reduces；3. intracellular pigment can accumulate；4. intracellular respiration rate subtracts
Slowly, nucleus volume increases, nuclear membrane infolding, chromatin condensation, color burn.Mitochondria quantity is reduced, and volume increases；5. cell
Membrane permeability function changes, and makes the reduction of matter transportation function.
Summary of the invention
An object of the present invention is to provide one kind to be used for the regenerated composition of cell-stimulating.
Of the invention is used for the regenerated composition of cell-stimulating, the raw material crushed including following weight：Human epidermal growth
20 parts~40 parts of the factor, 5 parts~22 parts of vascular endothelial growth factor, 2 parts~12 parts of platelet derived growth factor, at fiber finer
1 part~10 parts of the intracellular growth factor, 20 parts~30 parts of Chinese gall, 2 parts~10 parts of Radix Glycyrrhizae and 3 parts~8 parts of Asian puccoon.
Of the invention is used for the regenerated composition of cell-stimulating, can activate body, Facial Depression and relaxation skin, increase
Skin elasticity reaches competent cell state, additionally it is possible to and promote reepithelialization and generate collagen, repairs epithelial cell,
Promote angiogenic growth, can also dissipate extravasated blood, improve oily skin and pale skin quality, and make the skin cell proliferation point of aging
Change, accelerate fibroblastic generation, repair the elastic fibers and collagenous fibres of fracture, improve skin histology, scar is inhibited to increase
It is raw.Its effect is good, quick, high-efficient, has good commercial promise.
In addition, the present invention is above-mentioned to be used for the regenerated composition of cell-stimulating, there can also be following additional technology special
Sign：
Further, the raw material for being used for the regenerated composition of cell-stimulating, further including following weight crushes：Conversion
1 part~8 parts of growth factor, 0.1 part~1 part of Radix Astragali, 0.2 part~2 parts of dried orange peel, 1 part~3 parts of Radix Codonopsis and raw Rhizoma Atractylodis Macrocephalae 0.1 part~2
Part.
Further, the described raw material for being used for the regenerated composition of cell-stimulating, being crushed including following weight：Human body table
40 parts of skin growth factor, 5 parts of vascular endothelial growth factor, 12 parts of platelet derived growth factor, desmocyte growth factor-21
Part, 8 parts of transforming growth factor, 20 parts of Chinese gall, 10 parts of Radix Glycyrrhizae, 8 parts of Asian puccoon, 0.1 part of Radix Astragali, 2 parts of dried orange peel, 1 part of Radix Codonopsis and life
2 parts of Rhizoma Atractylodis Macrocephalae.
Further, the described raw material for being used for the regenerated composition of cell-stimulating, being crushed including following weight：Human body table
20 parts of skin growth factor, 22 parts of vascular endothelial growth factor, 2 parts of platelet derived growth factor, fibroblast growth factor
10 parts, transforming growth factor 1 part, 30 parts of Chinese gall, 2 parts of Radix Glycyrrhizae, 3 parts of Asian puccoon, 1 part of Radix Astragali, 0.2 part of dried orange peel, 3 parts of Radix Codonopsis and life
0.1 part of Rhizoma Atractylodis Macrocephalae.
Further, the described raw material for being used for the regenerated composition of cell-stimulating, being crushed including following weight：Human body table
30 parts of skin growth factor, 12 parts of vascular endothelial growth factor, 7 parts of platelet derived growth factor, fibroblast growth factor 5
Part, 4 parts of transforming growth factor, 25 parts of Chinese gall, 6 parts of Radix Glycyrrhizae, 5 parts of Asian puccoon, 0.5 part of Radix Astragali, 1 part of dried orange peel, 1 part of Radix Codonopsis and life are white
1 part of art.
It is another object of the present invention to propose the preparation method for the regenerated composition of cell-stimulating.
The preparation method for the regenerated composition of cell-stimulating, includes the following steps：S101：By described five times
Then grind into powder after the sub and described Radix Glycyrrhizae drying is 1 according to the mass ratio of the raw material and water:It is heated to boiling after 3 mixing
It rises, and keeps the temperature 2h~5h, then the quality of infusion to the water is original 1/5th；S102：Remaining Chinese herbal medicine is former
Material drying after grind into powder, be then added in the material that the step S101 is obtained, add ginger essential oil and water, then plus
Then heat filters to boiling and keeping the temperature 3h~5h and collects filtrate；Wherein, the mass ratio of the ginger essential oil and water is 2:1；It is described
The quality sum of ginger essential oil and water is 3 times of the raw material dry weight；S103：It is added in the filtrate obtained to the step S102 surplus
Remaining raw material components simultaneously stir, and obtain for the regenerated composition of cell-stimulating.
Further, in the step S101 and the step S102, the partial size of the powder is 1 μm~100 μm.
Further, in the step S101 and the step S102, the temperature that when drying uses for 50 DEG C~70 DEG C,
The time of drying is 1h~2h.
Another object of the present invention be to propose the Chinese medicine composition prepare the regenerated drug of cell-stimulating or
Application in health care product.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Specific embodiment
The embodiment of the present invention is described below in detail, the embodiment is exemplary, it is intended to it is used to explain the present invention, and
It is not considered as limiting the invention.
Embodiment 1
Embodiment 1 proposes a kind of for the regenerated composition of cell-stimulating, the raw material crushed including following weight：Human body
40 parts of epidermal growth factor, 5 parts of vascular endothelial growth factor, 12 parts of platelet derived growth factor, Desmocyte growth factor
Son 1 part, 8 parts of transforming growth factor, 20 parts of Chinese gall, 10 parts of Radix Glycyrrhizae, 8 parts of Asian puccoon, 0.1 part of Radix Astragali, 2 parts of dried orange peel, 1 part of Radix Codonopsis and
Raw 2 parts of Rhizoma Atractylodis Macrocephalae.
The preparation method for the regenerated composition of cell-stimulating of embodiment 1, includes the following steps：
(1) it is ground into the powder that partial size is 1 μm after the Chinese gall and the Radix Glycyrrhizae being dried 2h at 50 °C, so
It is afterwards 1 according to the mass ratio of the raw material and water:It is heated to boiling after 3 mixing, and keeps the temperature 5h, then the matter of infusion to the water
Amount is original 1/5th.
(2) remaining herbal raw material is dried to the powder for being ground into that partial size is 1 μm after 2h at 50 °C, then plus
Enter in the material obtained to the step (1), add ginger essential oil and water, be then heated to boiling and keep the temperature 5h, then filters
And collect filtrate；Wherein, the mass ratio of the ginger essential oil and water is 2:1；The quality sum of the ginger essential oil and water is the original
3 times for expecting dry weight.
(3) surplus stock component is added in the filtrate obtained to the step (2) and stirs, obtains for cell-stimulating again
Raw composition.
Embodiment 2
Embodiment 2 proposes a kind of for the regenerated composition of cell-stimulating, the raw material crushed including following weight：Human body
20 parts of epidermal growth factor, 22 parts of vascular endothelial growth factor, 2 parts of platelet derived growth factor, Desmocyte growth factor
Son 10 parts, transforming growth factor 1 part, 30 parts of Chinese gall, 2 parts of Radix Glycyrrhizae, 3 parts of Asian puccoon, 1 part of Radix Astragali, 0.2 part of dried orange peel, 3 parts of Radix Codonopsis and
Raw 0.1 part of Rhizoma Atractylodis Macrocephalae.
The preparation method for the regenerated composition of cell-stimulating of embodiment 2, includes the following steps：
(1) it is ground into the powder that partial size is 100 μm after the Chinese gall and the Radix Glycyrrhizae to be dried to 1h at a temperature of 70 DEG C,
It then is 1 according to the mass ratio of the raw material and water:It is heated to boiling after 3 mixing, and keeps the temperature 2h, then infusion to the water
Quality is 1/5th originally.
(2) it is ground into the powder that partial size is 100 μm after remaining herbal raw material to be dried to 1h at a temperature of 70 DEG C, then
It is added in the material that the step (1) obtains, adds ginger essential oil and water, be then heated to boiling and keep the temperature 3h, then mistake
It filters and collects filtrate；Wherein, the mass ratio of the ginger essential oil and water is 2:1；The quality sum of the ginger essential oil and water is described
3 times of raw material dry weight.
(3) surplus stock component is added in the filtrate obtained to the step (2) and stirs, obtains for cell-stimulating again
Raw composition.
Embodiment 3
Embodiment 3 proposes a kind of for the regenerated composition of cell-stimulating, the raw material crushed including following weight：Human body
30 parts of epidermal growth factor, 12 parts of vascular endothelial growth factor, 7 parts of platelet derived growth factor, Desmocyte growth factor
Son 5 parts, 4 parts of transforming growth factor, 25 parts of Chinese gall, 6 parts of Radix Glycyrrhizae, 5 parts of Asian puccoon, 0.5 part of Radix Astragali, 1 part of dried orange peel, 1 part of Radix Codonopsis and
Raw 1 part of Rhizoma Atractylodis Macrocephalae.
The preparation method for the regenerated composition of cell-stimulating of embodiment 3, includes the following steps：
(1) powder that partial size is 50 μm is ground into after the Chinese gall and the Radix Glycyrrhizae to be dried to 1.5h at a temperature of 60 DEG C
Then end is 1 according to the mass ratio of the raw material and water:It is heated to boiling after 3 mixing, and keeps the temperature 3.5h, then infusion to institute
The quality of water is stated as original 1/5th.
(2) it is ground into the powder that partial size is 50 μm after remaining herbal raw material to be dried to 1.5h at a temperature of 60 DEG C, so
It is added in the material that the step (1) obtains afterwards, adds ginger essential oil and water, be then heated to boiling and keep the temperature 4h, then
It filters and collects filtrate；Wherein, the mass ratio of the ginger essential oil and water is 2:1；The quality sum of the ginger essential oil and water is institute
3 times for stating raw material dry weight.
(3) surplus stock component is added in the filtrate obtained to the step (2) and stirs, obtains for cell-stimulating again
Raw composition.
To sum up, of the invention to be used for the regenerated composition of cell-stimulating, body, Facial Depression and relaxation flesh can be activated
Skin increases skin elasticity, reaches competent cell state, additionally it is possible to promote reepithelialization and generate collagen, in reparation
Chrotoplast promotes angiogenic growth, and can also dissipate extravasated blood, improves oily skin and pale skin quality, and make the Skin Cell of aging
Proliferation, Differentiation accelerates fibroblastic generation, repairs the elastic fibers and collagenous fibres of fracture, improves skin histology, inhibits
Scar hyperplasia.Its effect is good, quick, high-efficient, has good commercial promise.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (9)
1. one kind is used for the regenerated composition of cell-stimulating, which is characterized in that the raw material crushed including following weight：Human epidermal
0 part~40 parts of growth factor-2,5 parts~22 parts of vascular endothelial growth factor, 2 parts~12 parts of platelet derived growth factor, at fibre
Dimension growth factor-21 part~10 part, 20 parts~30 parts of Chinese gall, 2 parts~10 parts of Radix Glycyrrhizae and 3 parts~8 parts of Asian puccoon.
2. according to claim 1 be used for the regenerated composition of cell-stimulating, which is characterized in that further include following weight powder
Broken raw material：Transforming growth factor 1 part~8 part, 0.1 part~1 part of Radix Astragali, 0.2 part~2 parts of dried orange peel, 1 part~3 parts of Radix Codonopsis and life
0.1 part~2 parts of Rhizoma Atractylodis Macrocephalae.
3. according to claim 2 be used for the regenerated composition of cell-stimulating, which is characterized in that crushed including following weight
Raw material：40 parts of GG hEGF, 8 parts of Asian puccoon, 5 parts of vascular endothelial growth factor, platelet derived growth factor 12
Part, desmocyte growth factor-21 part, 8 parts of transforming growth factor, 20 parts of Chinese gall, 10 parts of Radix Glycyrrhizae, 0.1 part of Radix Astragali, dried orange peel 2
Part, 1 part of Radix Codonopsis and raw 2 parts of Rhizoma Atractylodis Macrocephalae.
4. according to claim 2 be used for the regenerated composition of cell-stimulating, which is characterized in that crushed including following weight
Raw material：20 parts of GG hEGF, 22 parts of vascular endothelial growth factor, 2 parts of platelet derived growth factor, at fiber
Cell growth factor 10 part, transforming growth factor 1 part, 30 parts of Chinese gall, 2 parts of Radix Glycyrrhizae, 3 parts of Asian puccoon, 1 part of Radix Astragali, dried orange peel 0.2
Part, 3 parts of Radix Codonopsis and raw 0.1 part of Rhizoma Atractylodis Macrocephalae.
5. according to claim 2 be used for the regenerated composition of cell-stimulating, which is characterized in that crushed including following weight
Raw material：30 parts of GG hEGF, 12 parts of vascular endothelial growth factor, 7 parts of platelet derived growth factor, at fiber
5 parts of Porcine HGF, 4 parts of transforming growth factor, 25 parts of Chinese gall, 6 parts of Radix Glycyrrhizae, 5 parts of Asian puccoon, 0.5 part of Radix Astragali, 1 part of dried orange peel,
1 part of Radix Codonopsis and raw 1 part of Rhizoma Atractylodis Macrocephalae.
6. the described in any item preparation methods for the regenerated composition of cell-stimulating of claim 1-5, which is characterized in that packet
Include following steps：
S101：By grind into powder after the Chinese gall and Radix Glycyrrhizae drying, then according to the mass ratio of the raw material and water
It is 1:It is heated to boiling after 3 mixing, and keeps the temperature 2h~5h, then the quality of infusion to the water is original 1/5th；
S102：By grind into powder after the drying of remaining herbal raw material, it is then added to the material that the step S101 is obtained
In, ginger essential oil and water are added, boiling is then heated to and keeps the temperature 3h~5h, then filter and collect filtrate；Wherein, the ginger
The mass ratio of essential oil and water is 2:1；The quality sum of the ginger essential oil and water is 3 times of the raw material dry weight；
S103：Surplus stock component is added in the filtrate obtained to the step S102 and stirs, obtains for cell-stimulating again
Raw composition.
7. the preparation method according to claim 6 for the regenerated composition of cell-stimulating, which is characterized in that described
In step S101 and the step S102, the partial size of the powder is 1 μm~100 μm.
8. the preparation method according to claim 6 for the regenerated composition of cell-stimulating, which is characterized in that described
In step S101 and the step S102, for the temperature that when drying uses for 50 DEG C~70 DEG C, the time of drying is 1h~2h.
9. the described in any item Chinese medicine compositions of claim 1-8 are preparing answering in the regenerated drug of cell-stimulating or health care product
With.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113198003A (en) * | 2021-06-22 | 2021-08-03 | 万永年 | External liquid for preventing atrophic scars after skin injury and preparation method thereof |
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