CN108853407A - A kind of preparation method of Yanyan slice - Google Patents
A kind of preparation method of Yanyan slice Download PDFInfo
- Publication number
- CN108853407A CN108853407A CN201810863807.6A CN201810863807A CN108853407A CN 108853407 A CN108853407 A CN 108853407A CN 201810863807 A CN201810863807 A CN 201810863807A CN 108853407 A CN108853407 A CN 108853407A
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- tussilago
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- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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Abstract
The present invention relates to technical field of pharmaceuticals, in particular to a kind of preparation method of Yanyan slice.The preparation method includes the following steps：Radix scrophulariae, the tuber of stemona, asparagus fern, cortex moutan, Radix Ophiopogonis, Oroxylum indicum, glutinous rehmannia, Radix Isatidis, Chinese olive, cicada slough are taken, is extracted using the method that dynamic countercurrent extractive technique is combined with ultrasound assisted extraction technique, gained extracting solution is concentrated, and medicinal extract is obtained；The extractant of dynamic countercurrent extractive technique is ethanol water, and the ultrasonic frequency of ultrasound assisted extraction technique is 20~100KHz, and Extracting temperature is 60~85 DEG C, and extraction time is 60~120min；Medicinal extract, tussilago fine powder are mixed with adhesive, made pellet, peppermint oil mixing, dry, tabletting is added.Yanyan slice prepared by the present invention boils method and other control methods compared to traditional water decoction, improves extract yield, shortens extraction time.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, in particular to a kind of preparation method of Yanyan slice.
Background technique
Yanyan slice by radix scrophulariae, Radix Isatidis, asparagus fern, Radix Ophiopogonis, cortex moutan, the tuber of stemona (system), Chinese olive, tussilago (system), Oroxylum indicum,
Glutinous rehmannia, cicada slough, compound preparation made of 12 taste Chinese medicine of peppermint oil, record in《The Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation
Second (WS3-B-0331-90)》, there is the effect of Yin nourishing and lung moistening, clearing heat and detoxicating, clearing throat, antipruritic antibechic.For chronic
Dry throat caused by pharyngitis, pharynx are itched, the diseases such as irritable cough.
Radix scrophulariae is sweet, bitter, salty, cold in prescription, and with clearing heat and nourishing yin, detoxicating and resolving a mass is monarch drug in a prescription；It is Radix Rehmanniae, Radix Ophiopogonis, asparagus fern, clear
Fruit, isatis root, cortex moutan Six-element are ministerial drug, and the monarch and his subjects close 5, there is yin-nourishing tune lung, clearing heat and detoxicating, clearing throat function；The tuber of stemona
(system), tussilago (system), Oroxylum indicum, four taste of cicada slough are adjutant, there is moistening lung to arrest cough, clears phlegm；Menthol is pungent, cool, dispelling wind
Heat dissipation, head clearing, it is kind to control abscess of throat, to make medicine.Full side is puted forth effort with yin-nourishing, moistening lung, and take clearing heat and detoxicating, clearing throat,
The antipruritic function of wind-dispelling heat-dissipating, relieving cough and reducing sputum, relieving sore-throat experiences the heresy of wind-heat to the ferritic deficiency of Yin, easily very suitable from the disease of dryization, preferably controls
Pharyngitis caused by acute, chronic pharyngitis, dry throat, pharynx itch, dry, thirsty, cough, fever, foul wind, sweating and irritable cough,
The diseases such as hoarse voice, aphonia.
For the preparation process of traditional Yanyan slice, above 12 taste, in addition to peppermint oil, tussilago is ground into fine powder, sieving；
Ten taste such as remaining radix scrophulariae adds water to cook secondary, 3 hours first times, and second 2 hours, collecting decoction stood 24 hours, takes supernatant
Liquid is condensed into thick paste, mixes with Common Coltsfoot Flower, dry, and particle, spray plus peppermint oil is made, mixes, tabletted, sugar coating,
To obtain the final product.
But for traditional handicraft using the method for adding water to cook standing, taking supernatant, being condensed into thick paste, technique is more fallen
Afterwards, time-consuming, there is a problem of that effective component extraction rate is low, more than impurity, has seriously affected this product and clinically applied.Therefore it needs
The preparation method that a kind of effective component extraction rate is high while extraction time is short is provided.
Summary of the invention
In view of this, the present invention provides a kind of preparation methods of Yanyan slice.Extract yield can be improved in this method, and shortening mentions
Take the time.
In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：
The present invention provides a kind of preparation methods of Yanyan slice, include the following steps：
In parts by weight, 110~130 parts of radix scrophulariae, 80~100 parts of the tuber of stemona, 80~100 parts of asparagus fern, cortex moutan 80~100 are taken
Part, 80~100 parts of Radix Ophiopogonis, 20~40 parts of Oroxylum indicum, 80~100 parts of glutinous rehmannia, 140~160 parts of Radix Isatidis, 80~100 parts of Chinese olive,
It 20~40 parts of cicada slough, is extracted using the method that dynamic countercurrent extractive technique is combined with ultrasound assisted extraction technique, gained extracts
Liquid is concentrated, and medicinal extract is obtained；The extractant of dynamic countercurrent extractive technique is ethanol water, the ultrasound of ultrasound assisted extraction technique
Wave frequency rate is 20~100KHz, and Extracting temperature is 60~85 DEG C, and extraction time is 60~120min；
Medicinal extract, 80~100 parts of tussilago fine powder are mixed with adhesive, are made pellet, 0.2~0.4 part of peppermint oil is added and mixes
Even, dry, tabletting.
Dynamic countercurrent extractive technique be by the reasonable concentration arrangement of gradients of material between multiple extraction units and solvent and
Corresponding process configuration, in conjunction with the granularity of material, extraction unit group number, temperature and solvent dosage, circulation combination carries out material
A kind of new technology extracted.The technology is compared with the traditional method, and has the advantages that significant, extract yield and extraction efficiency height, energy
Continuous production, have a wide range of application, production cost it is low.
The principle of ultrasound assisted extraction technique is to utilize cavitation effect, fuel factor and the mechanical effect of ultrasound, ultrasonic cavitation effect
Plant cell should be made to rupture, fuel factor makes the temperature of decentralized medium or medicinal material increase and effective component is promoted to dissolve, mechanical effect
Medium particle is set to generate diffusion and the mass transfer for vibrating and strengthening medium.Compared with traditional extraction process, ultrasonic method, which has, extracts speed
Degree is fast, solvent usage is few, recovery rate is high, does not influence the characteristics of species activity and chemical structure.
In the prior art, there has been no Yanyan slices in terms of extracting preparation using crushing, ultrasound plus dynamic countercurrent combined extracting
Report, compare traditional handicraft, this method extraction time is short, effective component extraction rate is high, impurity is few.
Preferably, the volumn concentration of ethyl alcohol is 8%~10% in ethanol water.
Preferably, the volumn concentration of ethyl alcohol is 10% in ethanol water.
Preferably, ultrasound assisted extraction technique is to be ultrasonically treated in dynamic countercurrent extractor two sides.It can solve to surpass in this way
Acoustic energy distributing inhomogeneity, power extend the problem of reduction at any time.
Preferably, ultrasound assisted extraction technique is symmetrically to be ultrasonically treated in dynamic countercurrent extractor two sides.
Preferably, dynamic countercurrent extractive technique uses the mode of three tank groups：3 times of first tank are extracted as the 1st rank
Section --- gradient formation stages extract 3 times, new solvent are added every time, obtain extracting solution A1, A2, A3, collect extracting solution
A1；Then starting second stage --- adverse current is extracted the stage, and the solvent that extracting solution A2 is extracted as the 2nd tank the 1st time is extracted
Liquid B1 is simultaneously collected；The solvent that extracting solution A3 is extracted as the 2nd tank the 2nd time, obtains extracting solution B2；Extracting solution B2 is as the 3rd tank the 1st
The solvent of secondary extraction obtains extracting solution C1 and collects；Circuit sequentially extraction；Pure solvent is added in 3rd extraction of every tank.
Preferably, the dosage of extractant is 8~12 times of raw material gross weight；Raw material gross weight be radix scrophulariae, the tuber of stemona, asparagus fern,
Cortex moutan, Radix Ophiopogonis, Oroxylum indicum, glutinous rehmannia, Radix Isatidis, Chinese olive, cicada slough total weight.
Preferably, the dosage of extractant is 10 times of raw material gross weight.
Preferably, the ultrasonic frequency of ultrasound assisted extraction technique is 40~60KHz.
Preferably, the ultrasonic frequency of ultrasound assisted extraction technique is 50KHz.
Preferably, Extracting temperature is 75~85 DEG C.
Preferably, Extracting temperature is 80 DEG C.
Preferably, extraction time is 80~90min.
Preferably, extraction time 85min.
Preferably, concentration is concentrated using the method for vacuum rotary steam.
Preferably, the adding manner of peppermint oil is that spray adds.
Preferably, the ethanol water that adhesive is 60%~80%.
Preferably, the ethanol water that adhesive is 70%.
In embodiment provided by the invention, composition of raw materials is：120 parts of radix scrophulariae, 90 parts of the tuber of stemona, 90 parts of asparagus fern, cortex moutan
It is 90 parts, 90 parts of Radix Ophiopogonis, 90 parts of tussilago, 30 parts of Oroxylum indicum, 90 parts of glutinous rehmannia, 150 parts of Radix Isatidis, 90 parts of Chinese olive, 30 parts of cicada slough, thin
0.3 part of lotus oil.
Preferably, the grain fineness of tussilago fine powder is 80~100 mesh.
Preferably, the grain fineness of tussilago fine powder is 80 mesh.
Preferably, further including the steps that coating after tabletting.
Preferably, between dry and tabletting further including the steps that pharmaceutically acceptable auxiliary material is added.
Preferably, pharmaceutically acceptable auxiliary material is talcum powder and/or magnesium stearate.
Preferably, the tuber of stemona is the tuber of stemona after processing, which is：Tuber of stemona medicinal material is taken, impurity is removed, is cleaned, profit
Thoroughly, sheet is cut, it is dry.Weed out clast.
Preferably, tussilago is the tussilago after processing, which is：Withdrawal coltsfoot medicinal material, remove impurity and
Stubble weeds out grey bits.
The present invention provides a kind of preparation methods of Yanyan slice.The preparation method includes the following steps：In parts by weight, it takes
110~130 parts of radix scrophulariae, 80~100 parts of the tuber of stemona, 80~100 parts of asparagus fern, 80~100 parts of cortex moutan, 80~100 parts of Radix Ophiopogonis, the wooden butterfly
20~40 parts of butterfly, 80~100 parts of glutinous rehmannia, 140~160 parts of Radix Isatidis, 80~100 parts of Chinese olive, 20~40 parts of cicada slough, using dynamic
The method that adverse current extractive technique is combined with ultrasound assisted extraction technique extracts, and gained extracting solution is concentrated, and obtains medicinal extract；It is dynamic
The extractant of state adverse current extractive technique is ethanol water, and the ultrasonic frequency of ultrasound assisted extraction technique is 20~100KHz, is mentioned
Taking temperature is 60~85 DEG C, and extraction time is 60~120min；Medicinal extract, 80~100 parts of tussilago fine powder are mixed with adhesive,
0.2~0.4 part of peppermint oil mixing, dry, tabletting is added in pelleting.The present invention has one of following advantage：
Yanyan slice prepared by the present invention boils method and other control methods compared to traditional water decoction, improves extract yield, contracts
Short extraction time, more traditional to add water to cook the process time and shorten 50%, same material yield improves 30%.
The present invention is applied to ten kinds of Chinese medicines ultrasonic wave dynamic countercurrent extraction together of Yanyan slice for the first time.And it is extracted in adverse current
Vltrasonic device is added in device two sides respectively, solves the problems, such as that ultrasonic energy distributing inhomogeneity, power extend reduction at any time.
Specific embodiment
The invention discloses a kind of preparation method of Yanyan slice, those skilled in the art can use for reference present disclosure, suitably
Improve realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are for a person skilled in the art
It will be apparent that they are considered as being included in the present invention.Method and application of the invention is carried out by preferred embodiment
Description, related personnel obviously can not depart from the content of present invention, in spirit and scope to method described herein and application into
Row change or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
The preparation method of Yanyan slice of the present invention is：
Take radix scrophulariae 120g, tuber of stemona 90g, asparagus fern 90g, cortex moutan 90g, Radix Ophiopogonis 90g, tussilago 90g, Oroxylum indicum 30g, glutinous rehmannia
90g, Radix Isatidis 150g, Chinese olive 90g, cicada slough 30g, peppermint oil 0.3g are made as bulk pharmaceutical chemicals.Above 12 taste removes peppermint oil
Outside, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added in dynamic countercurrent extractor, ethanol water is total extraction
Solvent is taken, dosage is 10 times of ten taste medicine total weights, and for ethyl alcohol as extractant, extractant accounts for the percent by volume of total extractant
For 8-10%, Vltrasonic device is added in dynamic countercurrent extractor two sides respectively, ultrasonic frequency 20-100KHz, and 60-85 DEG C of temperature,
Extraction time 60-120min obtains extracting solution, and revolving purification is condensed into cream, and 70% ethyl alcohol, the pelleting of tussilago fine powder, spray is added
Add peppermint oil, mix, dry, tabletting, coating.
Raw materials used or reagent, instrument etc. can be purchased by market in a kind of preparation method of Yanyan slice provided by the invention
?.
Below with reference to embodiment, the present invention is further explained：
Embodiment 1
Pharyngitis tablet recipe is as follows：
1 Yanyan slice pharmaceutical formulation of table
| Component | Dosage | Component | Dosage |
| Radix scrophulariae | 120g | Asparagus fern | 90g |
| The tuber of stemona | 90g | Cortex moutan | 90g |
| Radix Ophiopogonis | 90g | Tussilago | 90g |
| Oroxylum indicum | 30g | Glutinous rehmannia | 90g |
| Radix Isatidis | 150g | Chinese olive | 90g |
| Cicada slough | 30g | Peppermint oil | 0.3g |
Preparation method is as follows：
Take radix scrophulariae 120g, tuber of stemona 90g, asparagus fern 90g, cortex moutan 90g, Radix Ophiopogonis 90g, tussilago 90g, Oroxylum indicum 30g, glutinous rehmannia
90g, Radix Isatidis 150g, Chinese olive 90g, cicada slough 30g, peppermint oil 0.3g are made as bulk pharmaceutical chemicals.
Above 12 taste, in addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added to dynamic inverse
It flows in extractor, ethanol water is total extractant, and dosage is 10 times of ten taste medicine total weights, and ethyl alcohol is mentioned as extractant
Taking agent to account for the percent by volume of total extractant is 10%, and Vltrasonic device, ultrasonic wave are added in dynamic countercurrent extractor two sides respectively
Frequency 50KHz, obtains extracting solution by 80 DEG C of temperature, extraction time 85min, and revolving purification is condensed into cream, 70% ethyl alcohol, coltsfoot is added
Flower fine powder pelleting, spray plus peppermint oil mix, and dry, tabletting, coating is made 1000, every slice weight 0.25g.
Embodiment 2
Pharyngitis tablet recipe is with table 1, preparation method：
In addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added in dynamic countercurrent extractor,
Ethanol water is total extractant, and dosage is 10 times of ten taste medicine total weights, and for ethyl alcohol as extractant, extractant accounts for total extraction
The percent by volume of solvent is 8%, and Vltrasonic device, ultrasonic frequency 100KHz, temperature are added in dynamic countercurrent extractor two sides respectively
60 DEG C, extraction time 120min of degree, obtains extracting solution, and revolving purification is condensed into cream, 70% ethyl alcohol, tussilago fine powder system is added
Grain, spray plus peppermint oil mix, and dry, tabletting, coating is made 1000, every slice weight 0.25g.
Embodiment 3
Pharyngitis tablet recipe is with table 1, preparation method：
In addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added in dynamic countercurrent extractor,
Ethanol water is total extractant, and dosage is 10 times of ten taste medicine total weights, and for ethyl alcohol as extractant, extractant accounts for total extraction
The percent by volume of solvent is 9%, and Vltrasonic device, ultrasonic frequency 20KHz, temperature are added in dynamic countercurrent extractor two sides respectively
85 DEG C, extraction time 60min, extracting solution is obtained, revolving purification is condensed into cream, 70% ethyl alcohol, the pelleting of tussilago fine powder is added,
Spray plus peppermint oil mix, and dry, tabletting, coating is made 1000, every slice weight 0.25g.
Comparative example 1
For pharyngitis tablet recipe with table 1, preparation method is traditional handicraft：
In addition to peppermint oil, tussilago is ground into fine powder, sieving；Ten taste such as remaining radix scrophulariae add water to cook it is secondary, it is 3 small for the first time
When, second 2 hours, collecting decoction stood 24 hours, takes supernatant, be condensed into thick paste, mix with Common Coltsfoot Flower, and it is dry,
Be made particle, spray plus peppermint oil mix, tabletted, sugar coating to get.
Comparative example 2
Pharyngitis tablet recipe is CN201310563279.X patent with table 1, preparation method application reference number, and specific method is：
Above 12 taste takes radix scrophulariae, the tuber of stemona, Radix Isatidis that 60% ethyl alcohol of 10 times of weight is added to extract secondary, and 1 hour every time,
Combined extract, filtering recycle ethyl alcohol, are condensed into thick paste, spare；Take asparagus fern, cortex moutan, Radix Ophiopogonis, tussilago (system), the wooden butterfly
It is secondary that butterfly, glutinous rehmannia, Chinese olive, eight taste medicine of cicada slough add the water of 10 times of weight to decoct, and 3 hours for the first time, second 2 hours, merges and decocts
Liquid is condensed into thick paste, spare；Peppermint oil separately is taken, it is spare with beta-cyclodextrin inclusion compound；The mixing of both the above thick paste, it is dry, it is added
Benexate Hydrochloride, mixing, is made particle, tabletting, coating to get.
Comparative example 3
Pharyngitis tablet recipe is CN201110381356.0 patent with table 1, preparation method application reference number, and specific method is：
Cortex moutan 90g is taken, is crushed, 70% ethyl alcohol of 1L is added, puts into microwave extracting apparatus and carries out microwave abstracting, is extracted
Power 400W is extracted 2 times, and 4 minutes every time, combining extraction liquid, concentration was added on D101 large pore resin absorption column, 50% ethyl alcohol
Elution, collects 5 times of amount column volume eluents, ethyl alcohol is recovered under reduced pressure, is concentrated and dried, obtains Cortex Moutan extract, spare；Take plate blue
Root 150g, Chinese olive 90g are crushed, and the water of 1.5L is added in mixing, puts into microwave extracting apparatus and carries out microwave abstracting, extract power
500W is extracted 2 times, and 5 minutes every time, combining extraction liquid, concentration was added on AB-8 large pore resin absorption column, 30% ethanol elution,
4 times of amount column volume eluents are collected, after with 55% ethanol elution, collect 4 times of amount column volume eluents, are closed with above-mentioned eluent
And ethyl alcohol is recovered under reduced pressure, and it is concentrated and dried, obtains plate blueness extract, it is spare；Take radix scrophulariae 120g, the tuber of stemona (system) 90g, asparagus fern 90g,
Radix Ophiopogonis 90g, tussilago (system) 90g, Oroxylum indicum 30g, glutinous rehmannia 90g, cicada slough 30g, are added to CO2In supercritical extract device, ethyl alcohol
As entrainer, entrainer account for total extractant percent by volume be 4%, extracting pressure 15MPa, 30 DEG C of temperature, CO2Flow
1ml/g crude drug min, extraction time 150min obtain supercritical extract, spare；Above-mentioned Cortex Moutan extract, plate blueness are extracted
Dextrin is added in object, supercritical extract mixing, and the pelleting of 70% ethyl alcohol is dry, sprays into peppermint oil 0.3g, magnesium stearate is added,
It mixes, tabletting, film coating is made 400, every slice weight 0.25g.
Comparative example 4
Pharyngitis tablet recipe is CN201310615918.2 patent with table 1, preparation method application reference number, and specific method is：
Take radix scrophulariae 120g, tuber of stemona 90g, asparagus fern 90g, cortex moutan 90g, Radix Ophiopogonis 90g, tussilago 90g, Oroxylum indicum 30g, glutinous rehmannia
90g, Radix Isatidis 150g, Chinese olive 90g, cicada slough 30g, peppermint oil 0.3g are added to CO2In supercritical extract device, ethyl alcohol is as entrainment
Agent, entrainer account for total extractant percent by volume be 4%, extracting pressure 15MPa, 30 DEG C of temperature, CO2Flow 1m1/g is raw
Medicine min, extraction time 150min obtain supercritical extract, starch are added, the pelleting of 70% ethyl alcohol, dry, tabletting is made
500, every slice weight 0.25g.
Comparative example 5
Pharyngitis tablet recipe is with table 1, and compared with embodiment 1-3, Vltrasonic device is in dynamic countercurrent extractor side, preparation method
For：
In addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added in dynamic countercurrent extractor,
Ethanol water is total extractant, and dosage is 10 times of ten taste medicine total weights, and for ethyl alcohol as extractant, extractant accounts for total extraction
The percent by volume of solvent is 10%, and Vltrasonic device, ultrasonic frequency 50KHz, temperature 80 are added in dynamic countercurrent extractor side
DEG C, extraction time 85min obtains extracting solution, and revolving purification is condensed into cream, and 70% ethyl alcohol, the pelleting of tussilago fine powder, spray is added
Add peppermint oil, mix, dry, tabletting, coating is made 1000, every slice weight 0.25g.
Comparative example 6
For pharyngitis tablet recipe with table 1, extracting parameter is different from embodiment 1-3, and preparation method is：
In addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added in dynamic countercurrent extractor,
Ethanol water is total extractant, and dosage is 10 times of ten taste medicine total weights, and for ethyl alcohol as extractant, extractant accounts for total extraction
The percent by volume of solvent is 15%, and Vltrasonic device, ultrasonic frequency 120KHz, temperature are added in dynamic countercurrent extractor two sides respectively
90 DEG C, extraction time 150min of degree, obtains extracting solution, and revolving purification is condensed into cream, 70% ethyl alcohol, tussilago fine powder system is added
Grain, spray plus peppermint oil mix, and dry, tabletting, coating is made 1000, every slice weight 0.25g.
Comparative example 7
For pharyngitis tablet recipe with table 1, extracting parameter is different from embodiment 1-3, and preparation method is：
In addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added in dynamic countercurrent extractor,
Ethanol water is total extractant, and dosage is 10 times of ten taste medicine total weights, and for ethyl alcohol as extractant, extractant accounts for total extraction
The percent by volume of solvent is 10%, and Vltrasonic device, ultrasonic frequency 120KHz, temperature are added in dynamic countercurrent extractor two sides respectively
60 DEG C, extraction time 140min of degree, obtains extracting solution, and revolving purification is condensed into cream, 70% ethyl alcohol, tussilago fine powder system is added
Grain, spray plus peppermint oil mix, and dry, tabletting, coating is made 1000, every slice weight 0.25g.
Comparative example 8
Pharyngitis tablet recipe is with table 1, the method individually extracted using dynamic countercurrent, and preparation method is：
Above 12 taste, in addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added to dynamic inverse
It flows in extractor, ethanol water is total extractant, and dosage is 10 times of ten taste medicine total weights, and ethyl alcohol is mentioned as extractant
Taking agent to account for the percent by volume of total extractant is 10%, 80 DEG C of temperature, extraction time 85min, obtains extracting solution, and revolving purifies,
It is condensed into cream, 70% ethyl alcohol, the pelleting of tussilago fine powder is added, spray plus peppermint oil mix, and dry, tabletting, coating is made
1000, every slice weight 0.25g.
Comparative example 9
Pharyngitis tablet recipe is with table 1, the method for individually using ultrasonic extraction, and preparation method is：
Above 12 taste, in addition to peppermint oil, tussilago is ground into fine powder, sieving；Remaining ten taste medicine is taken to be added to extractor
In, 10% ethanol water is Extraction solvent, and dosage is 10 times of ten taste medicine total weights, is mentioned using the method for ultrasonic extraction
It takes, ultrasonic frequency 50KHz, 80 DEG C of temperature, extraction time 85min, obtains extracting solution, revolving purification is condensed into cream, is added 70%
Ethyl alcohol, the pelleting of tussilago fine powder, spray plus peppermint oil mix, and dry, tabletting, coating is made 1000, every slice weight 0.25g.
Test example 1
According to State Food and Drug Administration national drug standards YBZ14192006-2009Z, Yanyan slice is detected
Character, identification, the inspection of tablet items, content, every group takes three batch samples to be tested, and data result is averaged, tree peony
Paeoniflorin content is calculated by 1.5% in skin.Experimental result is shown in Table 2.
2 different batches of embodiment of the present invention character of table, related substance, content detection result
As shown in Table 2, the compound Chinese medicinal preparation Yanyan slice and certain commercially available Yanyan slice of new process production is used in the present invention
And the Yanyan slice of comparative example, the character of drug, related substance, content do not have significant change.Test result shows production of the invention
The quality of product is stably and controllable.
Test example 2
Accelerated test is carried out to three batches of Yanyan slices prepared by the present embodiment 1, as a result referring to table 3, table 3 is the embodiment of the present invention
The Accelerated stability test result of the Yanyan slice of offer.
The Accelerated stability test result of the Yanyan slice provided in an embodiment of the present invention of table 3
| Sample batch | 0 month | Accelerate 1 month | Accelerate 2 months | Accelerate 3 months | Accelerate 6 months |
| 01 | 98 | 99 | 97 | 98 | 97 |
| 02 | 98 | 97 | 99 | 98 | 97 |
| 03 | 98 | 98 | 98 | 98 | 98 |
As shown in Table 3, pharyngitis tablet stability prepared by the present invention is preferable.
Test example 3
Reference literature《One surveys the contents for commenting cinnamic acid, Paeonol, scutelloside and gallic acid in method measurement Yanyan slice more》
Detection method, using 50% methanol as Extraction solvent.Using high performance liquid chromatography to other 3 kinds of important component cortex cinnamomis in Yanyan slice
When acid, scutelloside, Paeonol are analyzed, effective component extraction rate and extraction time to embodiment 1-3 and comparative example 1-9 into
Row is investigated, as a result as follows：
The effective component extraction rate of the present invention of table 4 and extraction time testing result
As shown in Table 4, other 3 kinds of important component cinnamic acids, scutelloside, root bark of tree peony phenol extractions in Yanyan slice prepared by the present invention
Rate is high, and extraction time is short, and extracting method of the present invention substantially increases extraction efficiency.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of preparation method of Yanyan slice, which is characterized in that include the following steps：
In parts by weight, take 110~130 parts of radix scrophulariae, 80~100 parts of the tuber of stemona, 80~100 parts of asparagus fern, 80~100 parts of cortex moutan,
80~100 parts of Radix Ophiopogonis, 20~40 parts of Oroxylum indicum, 80~100 parts of glutinous rehmannia, 140~160 parts of Radix Isatidis, 80~100 parts of Chinese olive, cicada
20~40 parts are sloughed off, is extracted using the method that dynamic countercurrent extractive technique is combined with ultrasound assisted extraction technique, gained extracting solution
It is concentrated, obtains medicinal extract；The extractant of the dynamic countercurrent extractive technique is ethanol water, the ultrasound assisted extraction technique
Ultrasonic frequency be 20~100KHz, Extracting temperature be 60~85 DEG C, extraction time be 60~120min；
The medicinal extract, 80~100 parts of tussilago fine powder are mixed with adhesive, are made pellet, 0.2~0.4 part of peppermint oil is added and mixes
Even, dry, tabletting.
2. preparation method according to claim 1, which is characterized in that the volume basis of ethyl alcohol contains in the ethanol water
Amount is 8%~10%.
3. preparation method according to claim 1, which is characterized in that the volume basis of ethyl alcohol contains in the ethanol water
Amount is 10%.
4. preparation method according to claim 1, which is characterized in that the ultrasound assisted extraction technique is to extract in dynamic countercurrent
Device two sides are ultrasonically treated.
5. the preparation method according to claim 4, which is characterized in that the ultrasound assisted extraction technique is to extract in dynamic countercurrent
Device two sides are symmetrically ultrasonically treated.
6. preparation method according to claim 1, which is characterized in that the ultrasonic frequency of the ultrasound assisted extraction technique is 40
~60KHz.
7. preparation method according to claim 1, which is characterized in that the Extracting temperature is 75~85 DEG C.
8. preparation method according to claim 1, which is characterized in that the extraction time is 80~90min.
9. preparation method according to claim 1, which is characterized in that the ethyl alcohol that described adhesive is 60%~80% is water-soluble
Liquid.
10. preparation method according to claim 1, which is characterized in that 120 parts of radix scrophulariae, 90 parts of the tuber of stemona, 90 parts of asparagus fern, male
90 parts of the root bark of tree peony, 90 parts of Radix Ophiopogonis, 90 parts of tussilago, 30 parts of Oroxylum indicum, 90 parts of glutinous rehmannia, 150 parts of Radix Isatidis, 90 parts of Chinese olive, cicada slough 30
Part, 0.3 part of peppermint oil.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007057A (en) * | 2007-01-17 | 2007-08-01 | 华南理工大学 | Extraction method of water soluble components from salvia miltiorrhiza by ultrasonic continuous countercurrent gradient |
| CN102397497A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Method for preparing tablets for treating pharyngitis |
| CN103656415A (en) * | 2013-12-20 | 2014-03-26 | 青岛琴诚医药技术有限公司 | Application of anti-pharyngitis tablet and preparation method thereof |
| CN106620008A (en) * | 2017-01-18 | 2017-05-10 | 石药集团江西金芙蓉药业股份有限公司 | Process for preparing belladonna liquid extract by ultrasonic dynamic multi-stage countercurrent extraction |
-
2018
- 2018-08-01 CN CN201810863807.6A patent/CN108853407A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007057A (en) * | 2007-01-17 | 2007-08-01 | 华南理工大学 | Extraction method of water soluble components from salvia miltiorrhiza by ultrasonic continuous countercurrent gradient |
| CN102397497A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Method for preparing tablets for treating pharyngitis |
| CN103656415A (en) * | 2013-12-20 | 2014-03-26 | 青岛琴诚医药技术有限公司 | Application of anti-pharyngitis tablet and preparation method thereof |
| CN106620008A (en) * | 2017-01-18 | 2017-05-10 | 石药集团江西金芙蓉药业股份有限公司 | Process for preparing belladonna liquid extract by ultrasonic dynamic multi-stage countercurrent extraction |
Non-Patent Citations (4)
| Title |
|---|
| 王玉峰等: ""动态超声逆流提取技术在连花清瘟胶囊生产中的应用"", 《中国中医药信息杂志》 * |
| 程伟等: "植物有效成分的连续逆流浸取技术研究现状 ", 《食品科学》 * |
| 罗永明: "《中药化学成分提取分离技术与方法》", 31 January 2016, 上海科学技术出版社 * |
| 韩伟等: "对中药提取分离新技术及其设备的研究 ", 《机电信息》 * |
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