CN108853376A - The medicine for external application and preparation method thereof for treating canker sore - Google Patents
The medicine for external application and preparation method thereof for treating canker sore Download PDFInfo
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- CN108853376A CN108853376A CN201811076228.3A CN201811076228A CN108853376A CN 108853376 A CN108853376 A CN 108853376A CN 201811076228 A CN201811076228 A CN 201811076228A CN 108853376 A CN108853376 A CN 108853376A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
The present invention relates to a kind of medicine for external application and preparation method thereof for treating canker sore, raw material components by weight, including:Evodia rutaecarpa 0.3-0.8 parts by weight, ground cinnamon 0.2-0.6 parts by weight and light-coloured vinegar 0.4-1 parts by weight;Preparation method includes step:Evodia rutaecarpa and cortex cinnamomi are crushed and are sieved respectively, evodiae powder and ground cinnamon are respectively obtained;Evodiae powder and ground cinnamon are mixed in proportion, light-coloured vinegar is added and is modulated, obtained pasty mixture is pharmaceutical composition.The present invention as raw material and carries out scientific matching using evodia rutaecarpa, cortex cinnamomi and light-coloured vinegar, and the medicine for external application being prepared has effects that canker sore, significant in efficacy, quick, easy to use, is applied at night, does not influence day's activities;Any Western medicine hormonal components, and without side-effects, the use of conventional medicament that can be larger to avoid side effect and undesirable therapeutic effect of safety are not added;The medicine for external application is more more significant than adult to the therapeutic effect of the canker sore of infant.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to a kind of medicine for external application for treating canker sore and its preparation side
Method.
Background technique
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in
The positions such as lip inside, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, the mucous membrane at these positions lack keratinization layer or angling compared with
Difference.Tongue ulcer refers to the canker sore for betiding tongue, tongue abdomen position.Sharp ache when canker sore is broken out, local cusalgia are bright
Aobvious, serious person also will affect diet, speak, and cause very big inconvenience to daily life;It can concurrent halitosis, chronic pharyngitis, constipation, head
Bitterly, the constitutional symptoms such as dizzy, nauseous, out of strength, irritated, fever, enlargement of lymph nodes.Canker sore is that many factors are comprehensive
The result of effect comprising local trauma, stress, food, drug, malnutrition, hormonal readiness change and vitamin or
Microelement deficiencies.Systemic disease, heredity, immune and microorganism may play important work in the generation, development of canker sore
With.Such as lack trace element zinc, iron, lacks folic acid, vitamin B12And malnutrition etc., immune function can be reduced, mouth is increased
A possibility that chamber ulcer is fallen ill;The bacteriums such as Streptococcus sanguis and helicobacter pylori are also in close relations with canker sore.Canker sore is logical
Often imply that body may have a potential systemic disease, canker sore and gastric ulcer, duodenal ulcer, ulcerative colitis,
Regional enteritis, hepatitis, female menstrual period, vitamin B complex malabsorption disease, vegetative nerve functional disturbance disease etc. are related.It is existing
Treatment canker sore medicament categories it is various, but curative effect is not significant mostly, or is easy to produce drug resistance, therefore, it is also desirable to
Novel drug is developed, to meet the needs of patient.
Summary of the invention
For the defects in the prior art, it is an object of that present invention to provide a kind of medicine for external application for treating canker sore and its systems
Preparation Method, as raw material and to carry out scientific matching using evodia rutaecarpa, cortex cinnamomi and light-coloured vinegar, the pharmaceutical composition being prepared has
The effect for the treatment of canker sore, it is easy to use, and safety is without side-effects.
To achieve the above object, technical solution provided by the invention is:
The present invention provides a kind of pharmaceutical composition for treating canker sore, raw material components include:Evodia rutaecarpa, cortex cinnamomi and white
Vinegar.Canker sore Chinese medicine can be described as " aphtha ", it is believed that caused by flaring up of deficient fire, can be discussed by Chinese medicine " guiding fire to origin " theory
It controls.
Treat the raw material components of the pharmaceutical composition of canker sore by weight, including:Evodia rutaecarpa 0.3-0.8 weight
Part, ground cinnamon 0.2-0.6 parts by weight and light-coloured vinegar 0.4-1 parts by weight.
Preferably, the raw material components of the pharmaceutical composition of canker sore are treated by weight, including:0.5 weight of evodia rutaecarpa
Measure part, 0.7 parts by weight of 0.4 parts by weight of ground cinnamon and light-coloured vinegar.
The present invention also provides the preparation methods of the pharmaceutical composition for the treatment of canker sore, including step:By evodia rutaecarpa and
Cortex cinnamomi crushes and is sieved respectively, respectively obtains evodiae powder and ground cinnamon;Evodiae powder and ground cinnamon are mixed in proportion, are added
Light-coloured vinegar is modulated, and obtained pasty mixture is pharmaceutical composition.It should be noted that obtained evodiae powder and ground cinnamon
Grain diameter be no more than 0.1mm.
The present invention also protects application of the pharmaceutical composition in preparation treatment stomatocace medicine and/or medicated premix.
The present invention also provides a kind of medicine for external application for treating canker sore, medicine for external application includes above-mentioned pharmaceutical composition.
The present invention also provides the preparation methods of the medicine for external application for the treatment of canker sore, including step:Pharmaceutical composition is put
It is placed on herbal application, obtains medicine for external application.
It should be noted that the application method of the medicine for external application for the treatment canker sore that the present invention is prepared is preferably:Enter
Bilateral " Yongquan acupoint " is externally applied to before sleeping, after 12 hours, pain can be substantially reduced, no longer influences feed, and it is removable in the daytime, it does not influence
Day's activities;Second day is externally applied to bilateral " Yongquan acupoint " before falling asleep again, and ulcer surface is visible after 12 hours is obviously reduced, repeatedly 3-
5, ulcer can heal.
The medicine for external application for the treatment canker sore that the present invention is prepared can be applied to the patient of various age brackets, treatment baby children
The effect of the canker sore of youngster is more more significant than adult.Child is the body of " immature yin and yang ", therefore quick result, adult's state of an illness
It is often complex, and adult vola cuticula is considered compared with infant's thickness, drug absorption is limited, therefore effective compared with infant
Slowly, but still it is more obvious than other drugs therapeutic effect.
The pharmaceutical composition of above method preparation can be further prepared into pharmaceutically acceptable dosage form as needed.This
Outside, protection scope of the present invention is also belonged to by drug made of active constituent of aforementioned pharmaceutical compositions.By by said medicine
Composition is prepared after directly preparing or being added pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable dosage form.
Include by taking external preparation as an example:Solution, patch, vina, tincture, gelling agent, liniment, aerosol, spray, ointment and painting
Film.The drug of above-mentioned various dosage forms can be prepared according to the conventional method of pharmaceutical field.
Technical solution provided by the invention has following beneficial effect:(1) present invention is using evodia rutaecarpa, cortex cinnamomi and white
Vinegar is as raw material and carries out scientific matching, and the pharmaceutical composition being prepared has effects that canker sore, significant in efficacy, takes effect
Fastly, easy to use, it is applied at night, does not influence day's activities;Any Western medicine hormonal components are not added, and safety is without side-effects, it can
To avoid the use for the conventional medicament that side effect is larger and therapeutic effect is undesirable;(2) medicine for external application provided by the invention treats baby
The effect of the canker sore of child is more more significant than adult, can rapidly alleviate infant and suffer from canker sore bring pain,
Can normal diet, mitigate parent's pressure;(3) preparation method provided by the invention can sufficiently discharge in raw medicinal material
Effective component so that the composition being prepared possesses good drug effect, and is easy to absorb;Preparation method is simple, production
It is at low cost, it has a good application prospect.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described.Implement below
Example is only used for clearly illustrating technical solution of the present invention, therefore is intended only as example, and cannot be used as a limitation and limit this hair
Bright protection scope.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following embodiment, is respectively provided with three
Secondary to repeat to test, data are the average value or mean+SD of three repeated experiments.
The each raw material component for preparing pharmaceutical composition of the present invention is according to parts by weight as matching, can be according to phase in production
The ratio answered increases or reduces, as large-scale production can by kilogram or as unit of ton, small-scale production can also in grams,
Weight can increase or reduce, but the quality proportioning constant rate between each composition.
The present invention provides a kind of pharmaceutical composition for treating canker sore, raw material components by weight, including:Evodia rutaecarpa
0.3-0.8 parts by weight, ground cinnamon 0.2-0.6 parts by weight and light-coloured vinegar 0.4-1 parts by weight.
In addition, including the following steps the present invention also provides the preparation method of aforementioned pharmaceutical compositions:
Evodia rutaecarpa and cortex cinnamomi are crushed and are sieved respectively, evodiae powder and ground cinnamon are respectively obtained;
Evodiae powder and ground cinnamon are mixed in proportion, light-coloured vinegar is added and is modulated, obtained pasty mixture is drug
Composition.
The present invention also provides a kind of medicine for external applications for treating canker sore, are that pharmaceutical composition is placed in herbal application
On be prepared.
Technical solution provided by the invention is described further combined with specific embodiments below.
Embodiment 1
The present embodiment provides a kind of pharmaceutical composition for treating canker sore, raw material components by weight, including:Wu Zhu
0.7 parts by weight of 0.5 parts by weight of cornel, 0.4 parts by weight of ground cinnamon and light-coloured vinegar.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material:
Evodia rutaecarpa and cortex cinnamomi are crushed and are sieved respectively, evodiae powder and ground cinnamon are respectively obtained;
Evodiae powder and ground cinnamon are mixed in proportion, light-coloured vinegar is added and is modulated, obtained pasty mixture is drug
Composition.
Embodiment 2
The present embodiment provides a kind of pharmaceutical composition for treating canker sore, raw material components by weight, including:Wu Zhu
0.4 parts by weight of 0.3 parts by weight of cornel, 0.6 parts by weight of ground cinnamon and light-coloured vinegar.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material:
Evodia rutaecarpa and cortex cinnamomi are crushed and are sieved respectively, evodiae powder and ground cinnamon are respectively obtained;
Evodiae powder and ground cinnamon are mixed in proportion, light-coloured vinegar is added and is modulated, obtained pasty mixture is drug
Composition.
Embodiment 3
The present embodiment provides a kind of pharmaceutical composition for treating canker sore, raw material components by weight, including:Wu Zhu
1 parts by weight of 0.8 parts by weight of cornel, 0.2 parts by weight of ground cinnamon and light-coloured vinegar.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material:
Evodia rutaecarpa and cortex cinnamomi are crushed and are sieved respectively, evodiae powder and ground cinnamon are respectively obtained;
Evodiae powder and ground cinnamon are mixed in proportion, light-coloured vinegar is added and is modulated, obtained pasty mixture is drug
Composition.
Embodiment 4
The present embodiment provides a kind of medicine for external applications for treating canker sore, are the pharmaceutical compositions that embodiment 1 is prepared
Object is placed on herbal application and is prepared.
The application method of the medicine for external application for the treatment canker sore that the embodiment of the present invention 4 is prepared is:It is externally applied to before sleep
Bilateral " Yongquan acupoint ", after 12 hours, pain can be substantially reduced, no longer influences feed, removable in the daytime, does not influence day's activities;
Second day is externally applied to bilateral " Yongquan acupoint " before falling asleep again, and ulcer surface is visible after 12 hours is obviously reduced, and 3-5 days repeatedly, ulcer
It can heal.
The present invention as raw material and carries out scientific matching using evodia rutaecarpa, cortex cinnamomi and light-coloured vinegar, the pharmaceutical composition being prepared
Object has effects that canker sore, significant in efficacy, quick, easy to use, is applied at night, does not influence day's activities;It does not add
Any Western medicine hormonal components, and safety is without side-effects, conventional medicament that can be larger to avoid side effect and undesirable therapeutic effect
Use;The medicine for external application is more more significant than adult to the therapeutic effect of the canker sore of infant.
Several typical cases are set forth below.
1, certain is talked, female, 42 years old, teacher, with canker sore more than 5 years, intermittence occurred, this canker sore is continued above
One week, oral cavity pain, eating difficulties, with halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, out of strength, irritated, fever etc.
Symptom;Seriously affect work of attending class.The medicine for external application for the treatment canker sore for beginning to use the embodiment of the present invention 4 to be prepared afterwards,
Bilateral " Yongquan acupoint " is externally applied to before sleep, after 12 hours, pain is substantially reduced, no longer influences feed, takes down in the daytime;Second day enters
It is externally applied to bilateral " Yongquan acupoint " again before sleeping, ulcer surface is obviously reduced after 12 hours, and 3 days repeatedly, ulcer healing, feed was normal,
Halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, out of strength, irritated, heating paresthesia disappear.Follow-up 2 years afterwards, without multiple again
Hair.
2, certain is thanked, male, 36 years old, sale was suffered from canker sore 3 years, is frequently gone on business because of work, and diet work and rest is irregular,
Canker sore is caused to delay to eradicate, the insomnia and dreamful sleep that occurs together, mouth parched and tongue scorched, constipation etc..After begin to use the embodiment of the present invention 4
The medicine for external application for the treatment canker sore being prepared is externally applied to bilateral " Yongquan acupoint " before sleep, after 12 hours, pain obviously subtracts
Gently, it takes down in the daytime;Second day is externally applied to bilateral " Yongquan acupoint " before falling asleep again, and ulcer surface is obviously reduced after 12 hours, and repeatedly 4
Day, ulcer healing, symptom disappears.Follow-up 1 year afterwards, does not recur again.
3, Sun, female, 08 months 1 years old, for canker sore with pain 2 days, infant pain was obvious, had the fidgets, refuse into
Food, salivation is more than, and with fever, cheek, lip mucous membrane have apparent hyperemia, there is the multiple ulcer to differ in size, and tenderness is obvious.After open
The medicine for external application for the treatment canker sore being prepared using the embodiment of the present invention 4 that begins is applied with because infant repels, therefore entered in infant
Bilateral " Yongquan acupoint " is externally applied to after sleeping, after 12 hours, pain is substantially reduced, and infant is no longer cry and screamed, and can normally feed, take in the daytime
Fall;Second day is externally applied to bilateral " Yongquan acupoint " after falling asleep again, and ulcer surface is obviously reduced after 12 hours, and 3 days repeatedly, ulcer was cured
It closes, feed is completely normal, and symptom disappears, and does not have recurrence again within follow-up 15 months.
4, Zhai, male, 56 years old, lung cancer postoperative chemotherapy, alopecia was serious and with ulcer at oral cavity 6, used a variety of medicines
Object is invalid.The medicine for external application for the treatment canker sore for beginning to use the embodiment of the present invention 4 to be prepared afterwards, pain subtracts after external application 1 day
Gently, it takes down in the daytime, continuous night use is after 5 days, ulcer all healed at 6.Follow-up 1 year afterwards, does not recur again.
It should be noted that unless otherwise indicated, technical term or scientific term used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, it otherwise illustrates in these embodiments
Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustratively, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the present invention, it is to be understood that, term " first ", " second " are used for description purposes only, and cannot
It is interpreted as indication or suggestion relative importance or implicitly indicates the quantity of indicated technical characteristic.Define as a result, " the
One ", the feature of " second " can explicitly or implicitly include one or more of the features.In the description of the present invention,
The meaning of " plurality " is two or more, unless otherwise specifically defined.
Finally it should be noted that:The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations;To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, those skilled in the art should understand that:Its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement;And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover in protection scope of the present invention.
Claims (7)
1. a kind of pharmaceutical composition for treating canker sore, which is characterized in that raw material components include:
Evodia rutaecarpa, cortex cinnamomi and light-coloured vinegar.
2. the pharmaceutical composition for the treatment of canker sore according to claim 1, which is characterized in that raw material components are by weight
Meter, including:
Evodia rutaecarpa 0.3-0.8 parts by weight, ground cinnamon 0.2-0.6 parts by weight and light-coloured vinegar 0.4-1 parts by weight.
3. the pharmaceutical composition for the treatment of canker sore according to claim 1, which is characterized in that raw material components are by weight
Meter, including:
0.7 parts by weight of 0.5 parts by weight of evodia rutaecarpa, 0.4 parts by weight of ground cinnamon and light-coloured vinegar.
4. the preparation method of the pharmaceutical composition of the described in any item treatment canker sore of claim 1-3, which is characterized in that packet
Include step:
Evodia rutaecarpa and cortex cinnamomi are crushed and are sieved respectively, evodiae powder and ground cinnamon are respectively obtained;
The evodiae powder and the ground cinnamon are mixed in proportion, light-coloured vinegar is added and is modulated, obtained pasty mixture is
Described pharmaceutical composition.
5. the described in any item pharmaceutical compositions of claim 1-3 are in preparation treatment stomatocace medicine and/or medicated premix
In application.
6. a kind of medicine for external application for treating canker sore, it is characterised in that:
The medicine for external application includes the described in any item pharmaceutical compositions of claim 1-3.
7. the preparation method of the medicine for external application for the treatment of canker sore as claimed in claim 6, which is characterized in that including step:
Pharmaceutical composition is placed on herbal application, the medicine for external application is obtained.
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CN201811076228.3A CN108853376A (en) | 2018-09-14 | 2018-09-14 | The medicine for external application and preparation method thereof for treating canker sore |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115957265A (en) * | 2022-12-30 | 2023-04-14 | 宁波坤行健医药科技有限公司 | Traditional Chinese medicine ointment for external treatment of deficient fire flaring up and preparation method and application thereof |
Citations (1)
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CN1104512A (en) * | 1993-12-28 | 1995-07-05 | 西南民族学院 | Medicine powder for aphtha |
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2018
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1104512A (en) * | 1993-12-28 | 1995-07-05 | 西南民族学院 | Medicine powder for aphtha |
Non-Patent Citations (4)
Title |
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张德邦等: "中西药内外合用治疗难治性口疮疗效观察 ", 《现代中西医结合杂志》 * |
才瑞慧等: "中药敷涌泉穴治疗小儿口疮临床观察", 《牡丹江医学院学报》 * |
欧广升: "《慢性病外治妙术》", 30 April 2009, 湖南科学技术出版社 * |
程爵棠: "《手足疗法治百病》", 31 January 2018, 河南科学技术出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115957265A (en) * | 2022-12-30 | 2023-04-14 | 宁波坤行健医药科技有限公司 | Traditional Chinese medicine ointment for external treatment of deficient fire flaring up and preparation method and application thereof |
CN115957265B (en) * | 2022-12-30 | 2024-02-13 | 宁波坤行健医药科技有限公司 | Traditional Chinese medicine external treatment ointment for treating flaming up of deficiency fire and preparation method and application thereof |
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