CN102793907B - Medicament for treating oral ulcer (decay) and preparation method thereof - Google Patents
Medicament for treating oral ulcer (decay) and preparation method thereof Download PDFInfo
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- CN102793907B CN102793907B CN2012103193609A CN201210319360A CN102793907B CN 102793907 B CN102793907 B CN 102793907B CN 2012103193609 A CN2012103193609 A CN 2012103193609A CN 201210319360 A CN201210319360 A CN 201210319360A CN 102793907 B CN102793907 B CN 102793907B
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Abstract
The invention relates to a medicament for treating oral ulcer (decay) and a preparation method thereof. Particularly, the medicament is traditional Chinese medicine prepared by taking Chinese thorowax root, agilawood, sea buckthorn, pawpaw, endothelium corneum gigeriae galli, pepper, codonopsis pilosula, cinnamon, liquorice, rhizoma zingiberis, Chinese angelica, medicated leaven and other traditional Chinese medicine as raw materials. The medicament is formed by refining the pure traditional Chinese medicine and has good effects of anti-ulcer, hemostasis and analgesia, the oral ulcer is not easy to reoccur, and all the components conform to the provisions of the medical administration regulations.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of oral ulcer.
Background technology
Oral ulcer is called " aphtha " again, is the superficial ulcer that occurs on the oral mucosa, big I from the grain of rice to the Semen Glycines size, circular or oval, ulcer surface is recessed, congested on every side.Ulcer has characteristics such as periodicity, recurrent and self limiting, good sending out in lip, cheek, lingual margin etc.The cause of disease and mechanism of causing a disease are still indeterminate.Oral ulcer (rotting) is relevant with following factor: digestive system disease and dysfunction, hormonal change, Nervous and Mental Factors, inherited genetic factors and other factors etc.Suffering from the patient Yi Fasheng oral ulcer of digestive system disease, mainly is to cause a disease by influencing immune system.Oral ulcer is relevant with gastric ulcer, duodenal ulcer, ulcerative colitis, regional enteritis, hepatitis etc.Inducement may be local wound, psychentonia, food, medicine, hormonal readiness change and vitamin or trace element deficiency, and systemic disease, heredity, immunity and microorganism may play an important role in its generation, development.At present, to the Drug therapy of oral cavity ulcer, there is following deficiency in the treatment of oral ulcer both at home and abroad mainly based on topical therapeutic: pain relieving immediately, and the healing cycle is long, cures easily recurrence of back, and this is a world-famous puzzle.
Summary of the invention
The object of the present invention is to provide a kind of pure purification of tcm to form, have the medicine of the treatment oral ulcer (rotting) of good antiulcer, hemostasis and analgesic activity.
Another object of the present invention is to provide manufacturing method for above mentioned medicine.
In the present invention, except other explanations were arranged, the ratio that adopts was weight ratio.
Medicine of the present invention is to make (consumption is weight portion) by following component.
Radix Bupleuri 5-35 part Lignum Aquilariae Resinatum 15-35 part Fructus Hippophae 5-35 part
Fructus Chaenomelis 15-35 part Endothelium Corneum Gigeriae Galli 15-35 part Pericarpium Zanthoxyli 15-35 part
Radix Codonopsis 15-35 part Cortex Cinnamomi 1 5-35 part Radix Glycyrrhizae 15-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 1 5-35 part Massa Medicata Fermentata 15-35 part.
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Radix Bupleuri 8-35 part Lignum Aquilariae Resinatum 10-35 part Fructus Hippophae 18-35 part
Fructus Chaenomelis 8-35 part Endothelium Corneum Gigeriae Galli 8-35 part Pericarpium Zanthoxyli 10-35 part
Radix Codonopsis 10-35 part Cortex Cinnamomi 10-35 part Radix Glycyrrhizae 10-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 10-35 part Massa Medicata Fermentata 10-35 part.
The optimum weight proportioning of medicine of the present invention is:
15 parts of 10 portions of Fructus Hippophaes of 10 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
25 parts in 15 portions of Pericarpium Zanthoxylies of 20 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
15 parts in 25 portions of Radix Glycyrrhizaes of 10 portions of Cortex Cinnamomis of Radix Codonopsis
10 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Above-mentioned each component is made medicine production method of the present invention is:
Earlier Radix Codonopsis, Pericarpium Zanthoxyli are distinguished parching to brown with low baking temperature; Extracting liquorice is fried with low baking temperature and is done; Radix Bupleuri is fried with rice vinegar and is done (rice vinegar: the Radix Bupleuri weight ratio is 1:7-20); Medicines such as Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Fructus Chaenomelis and above-mentioned Radix Codonopsis, Pericarpium Zanthoxyli, Radix Glycyrrhizae, Radix Bupleuri are crushed to 120 order fine powders the above-mentioned fine powder that mixes are incubated 10 minutes down at 110 ℃, and then 20 minutes sterilizings of 100-105 ℃ of maintenance of cooling, make powder.
Above-mentioned powder can be processed on solid block dosage form, pill, tablet, electuary and any pharmaceutics dosage form, to satisfy different patients' needs.
Technical scheme of the present invention derives from former Xiangyang county stone bridge town Tian Shi family, is the century-old ancient prescription for the treatment of cholera disease, and the applicant forms with reference to modern pharmacology and pathological principle and through putting into practice for many years.Clinical drug of the present invention uses the result to show.
1, the present invention adopts pure purification of tcm to form, and each component all meets the regulation of doctor's politics and law rule, and it is to utilize the comprehensive function of the Chinese herbal medicine of respectively distinguishing the flavor of to cure the disease, and does not contain chemicals, and is nontoxic to human body.Need not decoct, not have obvious bitterness sense, certain nutrition is arranged, taking convenience meets the state food safety law.
2, have good adjusting equilibrium between yin and yang, spleen invigorating, stomach warming, nourishing the liver, the kidney invigorating, antiulcer, hemostasis and analgesic activity.Summary of experience according to twenties years: the present invention treats oral ulcer (rotting) allergic cough (throat is itched and coughed), and acute aphonia in silence.Particularly the oral cavity is by the foreign body wound, and ulcer (rotting) pain is unbearably the time, and containing into medicine of the present invention has the effect of getting instant result, and cures the back and is difficult for recurrence.
The present invention namely cures the disease and pain relieving, has broken the not pain relieving of medicine of curing the disease that whole world medicine person generally acknowledges, the rule that the medicine of pain relieving is not cured the disease.
The present invention (clinical title Rong Kun mountain gods) acute toxicity (animal) result of the test is: the dosage (be equivalent to be grown up dosage 100 times) by 43.2 grams/kilogram is given 20 big capacity perfusions of white mice 7 days, white mice all survives as a result, and body weight increases to some extent, all by testing (referring to the toxicity test of Rong Kun belalumas, Rong Kun mountain gods and the same prescription of Rong Kun belalumas, because of the position of only having replaced monarch, minister, having helped, making, so with reference to Rong Kun belalumas pharmacological effect and toxicity test result).
For showing medicine of the present invention to the therapeutic effect for the treatment of oral ulcer (rotting), the present invention is through the clinical observation of 204 routine systems, and clinical test results is as follows:
X
2＝3．62 ＜X
2＝3．62 P＜0．05。
The specific embodiment
Embodiment 1:
Take by weighing raw material by following weight proportion:
10 parts of 10 portions of Fructus Hippophaes of 8 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
15 parts in 12 portions of Pericarpium Zanthoxylies of 15 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
15 parts in 25 portions of Radix Glycyrrhizaes of 12 portions of Cortex Cinnamomis of Radix Codonopsis
8 parts of 8 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Earlier Radix Codonopsis, Pericarpium Zanthoxyli are distinguished parching to brown with low baking temperature; Extracting liquorice is fried with low baking temperature and is done; Radix Bupleuri is fried with rice vinegar and is done (rice vinegar: the Radix Bupleuri weight ratio is 1:7-20); Medicines such as Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Fructus Chaenomelis and above-mentioned Radix Codonopsis, Pericarpium Zanthoxyli, Radix Glycyrrhizae, Radix Bupleuri are crushed to 120 order fine powders the above-mentioned fine powder that mixes are incubated 10 minutes down at 110 ℃, and then 20 minutes sterilizings of 100-105 ℃ of maintenance of cooling, make powder.
Embodiment 2: take by weighing raw material by following weight proportion:
15 parts of 25 portions of Fructus Hippophaes of 20 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 10 portions of Pericarpium Zanthoxylies of 20 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 6 portions of Radix Glycyrrhizaes of 5 portions of Cortex Cinnamomis of Radix Codonopsis
10 parts of 8 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 3: take by weighing raw material by following weight proportion:
9 parts of 12 portions of Fructus Hippophaes of 7 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
10 parts in 10 portions of Pericarpium Zanthoxylies of 9 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
10 parts in 16 portions of Radix Glycyrrhizaes of 5 portions of Cortex Cinnamomis of Radix Codonopsis
8 parts of 8 parts of Massa Medicata Fermentata of 4 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 4: take by weighing raw material by following weight proportion
9 parts of 10 portions of Fructus Hippophaes of 6 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
10 parts in 10 portions of Pericarpium Zanthoxylies of 8 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
10 parts in 14 portions of Radix Glycyrrhizaes of 3 portions of Cortex Cinnamomis of Radix Codonopsis
5 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 5: take by weighing raw material by following weight proportion:
8 parts of 8 portions of Fructus Hippophaes of 5 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
9 parts in 9 portions of Pericarpium Zanthoxylies of 7 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
9 parts in 9 portions of Radix Glycyrrhizaes of 3 portions of Cortex Cinnamomis of Radix Codonopsis
3 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 6: take by weighing raw material by following weight proportion:
8 parts of 5 portions of Fructus Hippophaes of 5 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 8 portions of Pericarpium Zanthoxylies of 5 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 4 portions of Radix Glycyrrhizaes of 3 portions of Cortex Cinnamomis of Radix Codonopsis
2 parts of 3 parts of Massa Medicata Fermentata of 2 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Production method is as follows:
Earlier Radix Codonopsis, Pericarpium Zanthoxyli are distinguished parching to brown with low baking temperature; 2, the extracting liquorice sheet is fried with low baking temperature and is done; 3, Radix Bupleuri is fried with rice vinegar and is done (rice vinegar: Radix Bupleuri weight 1:7-20); 4, Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, and said medicine be crushed to 120 order fine powders; 5, the above-mentioned fine powder that mixes is incubated 10 minutes down at 110 ℃, and then the 100-105 ℃ of maintenance 20 minutes of lowering the temperature, sterilizing is made powder.
Claims (6)
1. treat oral ulcer/mashed medicine for one kind, it is characterized in that: it is the medicament of being made by the following weight proportion raw material:
Radix Bupleuri 5-35 part Lignum Aquilariae Resinatum 15-35 part Fructus Hippophae 5-35 part
Fructus Chaenomelis 15-35 part Endothelium Corneum Gigeriae Galli 15-35 part Pericarpium Zanthoxyli 15-35 part
Radix Codonopsis 15-35 part Cortex Cinnamomi 1 5-35 part Radix Glycyrrhizae 15-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 1 5-35 part Massa Medicata Fermentata 15-35 part.
2. treat oral ulcer/mashed medicine for one kind, it is characterized in that: it is the medicament of being made by the following weight proportion raw material:
Radix Bupleuri 8-35 part Lignum Aquilariae Resinatum 10-35 part Fructus Hippophae 18-35 part
Fructus Chaenomelis 8-35 part Endothelium Corneum Gigeriae Galli 8-35 part Pericarpium Zanthoxyli 10-35 part
Radix Codonopsis 10-35 part Cortex Cinnamomi 10-35 part Radix Glycyrrhizae 10-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 10-35 part Massa Medicata Fermentata 10-35 part.
3. treat oral ulcer/mashed medicine for one kind, it is characterized in that: it is the medicament of being made by the following weight proportion raw material:
15 parts of 10 portions of Fructus Hippophaes of 10 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
25 parts in 15 portions of Pericarpium Zanthoxylies of 20 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
15 parts in 25 portions of Radix Glycyrrhizaes of 10 portions of Cortex Cinnamomis of Radix Codonopsis
10 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
4. according to claim 1,2 or 3 described treatment oral ulcer/mashed medicines, it is characterized in that said medicament is said dosage form on any pharmaceutics.
5. treatment oral ulcer according to claim 4/mashed medicine is characterized in that said medicament is powder, piece agent or honeyed pill.
6. the preparation method of the medicine of the described treatment oral ulcer of claim 4/mashed is characterized in that: earlier with Radix Codonopsis, Pericarpium Zanthoxyli with low baking temperature parching to brown respectively; Extracting liquorice is fried with low baking temperature and is done; Radix Bupleuri is fried with rice vinegar and is done, and rice vinegar: the Radix Bupleuri weight ratio is 1:7-20; Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Fructus Chaenomelis and above-mentioned Radix Codonopsis, Pericarpium Zanthoxyli, Radix Glycyrrhizae, Radix Bupleuri are crushed to 120 order fine powders, the above-mentioned fine powder that mixes is incubated 10 minutes down at 110 ℃, and then 20 minutes sterilizings of 100-105 ℃ of maintenance of cooling, make powder.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103193609A CN102793907B (en) | 2012-09-03 | 2012-09-03 | Medicament for treating oral ulcer (decay) and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012103193609A CN102793907B (en) | 2012-09-03 | 2012-09-03 | Medicament for treating oral ulcer (decay) and preparation method thereof |
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| CN102793907A CN102793907A (en) | 2012-11-28 |
| CN102793907B true CN102793907B (en) | 2013-09-18 |
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| CN102813902A (en) * | 2012-09-03 | 2012-12-12 | 李大坤 | Drug for treating stomach and intestine diseases and method for preparing drug for treating stomach and intestine disease |
| CN105233237A (en) * | 2015-11-20 | 2016-01-13 | 门源县雪草木生物药业有限公司 | Solid dispersion capsule for treatment of peptic ulcer |
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| CN1282610A (en) * | 1999-07-30 | 2001-02-07 | 李大坤 | Medicine for treating gastrointestinal diseases and its preparing process |
| CN101612383B (en) * | 2009-07-21 | 2011-03-30 | 吕启贵 | Medicine for treating stomach cancer and esophagus cancer and preparation method thereof |
| CN101708327B (en) * | 2009-10-27 | 2011-06-01 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diseases of weakness of spleen and stomach and indigestion and preparation method thereof |
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