CN108853346A - 一种治疗唇炎的外用药膏 - Google Patents
一种治疗唇炎的外用药膏 Download PDFInfo
- Publication number
- CN108853346A CN108853346A CN201811114075.7A CN201811114075A CN108853346A CN 108853346 A CN108853346 A CN 108853346A CN 201811114075 A CN201811114075 A CN 201811114075A CN 108853346 A CN108853346 A CN 108853346A
- Authority
- CN
- China
- Prior art keywords
- parts
- cheilitis
- beeswax
- bletilla
- coptis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000007287 cheilitis Diseases 0.000 title claims abstract description 33
- 239000002674 ointment Substances 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 27
- 238000011282 treatment Methods 0.000 claims abstract description 23
- 235000013871 bee wax Nutrition 0.000 claims abstract description 19
- 239000012166 beeswax Substances 0.000 claims abstract description 19
- 241001313855 Bletilla Species 0.000 claims abstract description 17
- 241000219784 Sophora Species 0.000 claims abstract description 17
- 244000036905 Benincasa cerifera Species 0.000 claims abstract description 16
- 235000011274 Benincasa cerifera Nutrition 0.000 claims abstract description 16
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 16
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 16
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000009835 boiling Methods 0.000 claims description 9
- 241000123069 Ocyurus chrysurus Species 0.000 claims description 7
- 239000003610 charcoal Substances 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 4
- 235000019504 cigarettes Nutrition 0.000 claims description 3
- 239000000571 coke Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 18
- 206010040882 skin lesion Diseases 0.000 abstract description 17
- 231100000444 skin lesion Toxicity 0.000 abstract description 17
- 208000002193 Pain Diseases 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 14
- 208000003251 Pruritus Diseases 0.000 abstract description 13
- 230000008961 swelling Effects 0.000 abstract description 9
- 230000003902 lesion Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 3
- 230000007803 itching Effects 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 12
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 240000008042 Zea mays Species 0.000 description 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 5
- 235000005822 corn Nutrition 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 5
- 230000037213 diet Effects 0.000 description 5
- 231100001274 therapeutic index Toxicity 0.000 description 5
- 239000003053 toxin Substances 0.000 description 5
- 231100000765 toxin Toxicity 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 206010020565 Hyperaemia Diseases 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 230000001114 myogenic effect Effects 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- 230000036269 ulceration Effects 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 210000000697 sensory organ Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 241000282537 Mandrillus sphinx Species 0.000 description 1
- 206010067994 Mucosal atrophy Diseases 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010040849 Skin fissures Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000000613 ear canal Anatomy 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 235000021191 food habits Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Insects & Arthropods (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明之目的是提供一种治疗唇炎的外用药膏，由以下重量份数计的：茜草炭60‑80份、黄连30‑50份、冬瓜子油300‑400份、白及9‑15份、槐花15‑20份和蜂蜡60‑80份制成；本发明纯中药配制，具有清热解毒，消肿止痛，祛风止痒之功效，有效于唇炎的治疗，可显著减轻患者皮损红肿瘙痒程度、改善皮损面积、皮损表现、促进皮损愈合，疗效好，用药安全，是治疗唇炎药物上的创新，经济和社会效益显著。
Description
技术领域
本发明涉及中药,尤其涉及一种治疗唇炎的外用药膏。
背景技术
唇炎是一种初期以唇部的干燥、红肿、痒痛、疱疹等，日久破溃流水，糜烂、结痴、起灰白色鳞屑为主要临床症状。病情易反反复复，可持续数月甚至数年不愈，或者患部可有暂时愈合，但常复发。是口腔黏膜病中常见的一组种类繁多、临床表型各异、病理变化和发病机制不同的疾病。文献报道慢性唇炎的发生可能与季节更替、天气突然变化、局部理化刺激、日光照射、精神因素、免疫失调、遗传等因素有关。近年来的临床患病率正呈逐年递增的趋势,由于本病会影响美观及饮食，对患者的身心健康及日常生活会有很大的影响,由于慢性唇炎的病因病机尚不明确,目前尚无确切有效的针对性治疗药物,临床主要采用局部使用激素或抗生素外涂、局部封闭或采用冷冻、激光、微波等物理疗法。局部应用糖皮质激素类药物能有效减轻唇部炎症，减少渗出，但是长期使用会出现局部黏膜萎缩、色素沉着等副作用，对于美观性要求较高的患者较难接受；冷冻、激光、微波等治疗价格昂贵，并且远期疗效不稳定，易复发，因此，提供一种能有效治疗唇炎的外用药膏势在必行。
发明内容
针对上述情况，为克服现有技术之缺陷，本发明之目的是提供一种治疗唇炎的外用药膏，可有效解决唇炎治疗的用药问题。
本发明解决的技术方案是，一种治疗唇炎的外用药膏，由以下重量份数计的：茜草炭60-80份、黄连30-50份、冬瓜子油300-400份、白及9-15份、槐花15-20份和蜂蜡60-80份制成；
其中，（1）将黄连、白及、槐花混合在一起，加混合药物重量7-10倍的水，浸泡1h，武火煎沸，改为文火煎煮30-60min，过滤，得第一次滤液，药渣加其重量7-10倍的水，武火煎沸，改为文火煎煮30-60min，过滤，得第二次滤液，药渣加其重量7-10倍的水，武火煎沸，改为文火煎煮30-60min，过滤，得第三次滤液，合并3次滤液，得提取液；
（2）将提取液在冷冻干燥机中浓缩，得到原提取液体积25%的提取液浸膏；
（3）将茜草放在无烟炭火中烧，烧至尚冒青烟、外面焦里面未焦，成茜草炭，研磨成过100-120目的茜草炭细粉；
（4）将蜂蜡在70-80℃水浴中加热熔融；
（5）将提取液浸膏、茜草炭细粉和冬瓜子油混合均匀，再加入熔融的蜂蜡，搅拌均匀，0-4℃冷却12小时，分装，密封保存，即为成品。
本发明纯中药配制，具有清热解毒，消肿止痛，祛风止痒之功效，有效于唇炎的治疗，可显著减轻患者皮损红肿瘙痒程度、改善皮损面积、皮损表现、促进皮损愈合，疗效好，用药安全，是治疗唇炎药物上的创新，经济和社会效益显著。
具体实施方式
以下结合实施例对本发明的具体实施方式做详细说明。
实施例1：本发明一种治疗唇炎的外用药膏，由以下重量份数计的：茜草炭65-75份、黄连35-45份、冬瓜子油320-380份、白及10-14份、槐花16-18份和蜂蜡65-75份制成；
其中，（1）将黄连、白及、槐花混合在一起，加混合药物重量8-9倍的水，浸泡1h，武火煎沸，改为文火煎煮40-50min，过滤，得第一次滤液，药渣加其重量8-9倍的水，武火煎沸，改为文火煎煮40-50min，过滤，得第二次滤液，药渣加其重量8-9倍的水，武火煎沸，改为文火煎煮40-50min，过滤，得第三次滤液，合并3次滤液，得提取液；
（2）将提取液在冷冻干燥机中浓缩，得到原提取液体积25%的提取液浸膏；
（3）将茜草放在无烟炭火中烧，烧至尚冒青烟、外面焦里面未焦，成茜草炭，研磨成过100-120目的茜草炭细粉；
（4）将蜂蜡在70-80℃水浴中加热熔融；
（5）将提取液浸膏、茜草炭细粉和冬瓜子油混合均匀，再加入熔融的蜂蜡，搅拌均匀，0-4℃冷却12小时，分装，密封保存，即为成品。
实施例2：
本发明一种治疗唇炎的外用药膏, 由以下重量份数计的：茜草炭60份、黄连30份、冬瓜子油300份、白及9份、槐花15份和蜂蜡60份制成；制备方法同实施例1。
实施例3：
本发明一种治疗唇炎的外用药膏，由以下重量份数计的：茜草炭70份、黄连40份、冬瓜子油350份、白及12份、槐花17.5份和蜂蜡70份制成，制备方法同实施例1。
实施例4：
本发明一种治疗唇炎的外用药膏, 由以下重量份数计的：茜草炭80份、黄连50份、冬瓜子油400份、白及15份、槐花20份和蜂蜡80份制成，制备方法同实施例1。
其中，茜草炭：凉血活血，祛瘀通经。用于吐血，衄血，崩漏，外伤出血，经闭瘀阻，关节痹痛，跌扑肿痛。
黄连：清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐魈，目赤，牙痛，痈肿疔疮等；外治湿疹，湿疮，耳道流脓。
冬瓜子油：润燥生津，用于疮疡，湿疹，水火烫伤。
白及：收敛止血，消肿生肌。用于咯血、吐血、外伤出血，疮疡肿毒，皮肤皲裂。
槐花：凉血止血，清肝泻火。用于吐血、衄血、便血、痔血、血痢，崩漏，肝热目赤，头痛眩晕。
唇炎与中医的“唇风”颇为相似，隋代医家巢元方在《诸病源候论·紧唇候》中指出：“脾胃有热，气发于唇，则唇生疮。而重被风邪寒湿之气搏于疮，则微肿湿烂，或冷或热，乍瘥乍发，积月累年，谓之紧唇，亦名沈唇。”其病位在中焦脾胃, 病机为脾胃湿热，火热上攻。 病因为患者过食辛辣厚味、吸烟嗜酒，导致脾胃受损，升降失调，运化失常，湿浊内生，日久化热，湿热之邪郁积成热毒，循经上扰于唇，熏蒸口唇而成红肿糜烂， 其次咬唇 、舔唇,使唇红受损, 复感风毒之邪气 , 导致湿热与风毒, 循经上蒸, 熏灼于唇 ,久之气血失畅 ,凝滞脉络而形成病损 ,加之风性易燥 ,耗伤津液 ,故唇部干燥、痒痛，日久破溃流水、结痴、起灰白色鳞屑。
本发明选用具有清热解毒，消肿止痛，燥湿生肌之功效的药物制作而成，本发明中茜草炭与黄连用量大，为君药，二者合用可达到清热解毒，燥湿止痒，对多种病毒有很好的抑制作用；冬瓜子油为臣药，外用可长时间保持唇部湿润，起到润燥生津、生肌敛疮之功效，易被皮肤吸收，可增强君药的功效；槐花和白及为佐使药，现代研究证明槐花有抗氧化及抗菌杀虫等功效，有益于保护皮肤黏膜，白及因其苦涩,具有一定的燥湿和收敛的功效,对皮肤黏膜溃烂、渗出等症状,可以发挥良好的使创面愈合的作用。蜂蜡主要为粘度调节剂，使药膏达到润滑，另外蜂蜡作为基质还具有收涩生肌止痛之作用为使药。
本发明选用具有清热滋阴润燥，消肿止痛功效的药物制作而成，互相支持，可直接作用于病变部位，保持唇部皮肤表面水分、促进皮肤新陈代谢，通过清热滋阴润燥，消肿止痛，可显著减轻患者皮损红肿瘙痒程度、改善皮损面积、皮损表现、促进皮损愈合，具有良好的治疗作用，适用于唇炎临床治疗与护理的推广应用，并经试验效果非常好，有关试验资料如下：
唇炎的入选标准及排除标准：
诊断依据参照由人民卫生出版社出版的第四版《口腔黏膜病学》和《中国临床皮肤病学》第2版中对慢性唇炎的诊断描述，皮损多见于下唇中部,后逐渐扩展到整个下唇或上下唇 ；上下唇充血肿胀、干燥、结痂、反复脱屑、皲裂,易出血；局部有烧灼感、刺痛或触痛 ；经久不愈,可持续数年或更久。
入选标准：临床症状符合慢性唇炎的表现；病程在15天以上；年龄大于1月的患者；征得患者同意
排除标准：对本发明药物药物过敏者；病损区有严重感染；1周内有局部使用糖皮质激素或其他免疫制剂患者或接受其他中药治疗者；合并有严重严重心血管、肝、肾系统等严重原发性疾病，合并有传染性疾病；近一月内参加其他药物临床实验者。且依从性差的患者。
病例选择
选择唇炎患者75例临床观察，病人随机分为2组 ，治疗组40例，其中男性12例，女性28例，年龄2月到16岁，平均年龄7.6岁，病程15天到2年；对照组35例，其中男性9例，女性26例，年龄2月到15岁，平均年龄7.1岁，病程15天到2年2月。两组比例的病程、病情程度基本一致，无显著差异，具有可比性。
药物选择
治疗组患者每次饭后 ,用温水清洗患处，涂抹本发明药膏，儿童每日1-2次，每次1-2g，均匀涂抹于患处，嘱患者饮食清淡,忌辛辣刺激性食物 ,避免日晒，改正舔唇咬唇的不良习惯。7天为1疗程。
对照组选用每次饭后 ,用温水清洗患处, 涂抹 3 %硼酸软膏，儿童每日1-2次，每次1-2g，均匀涂抹于患处。嘱患者饮食清淡,忌辛辣刺激性食物 ,避免日晒，改正舔唇咬唇的不良习惯。7天为1疗程。
观察指标：
观察治疗前后疼痛、干燥、瘙痒、充血、肿胀、鳞屑、糜烂等临床表现。采用 5级评分法，对患者以上症状进行量化。0级（0分）：唇部无不适症状；1级（1分）：唇部有轻微疼痛，自觉唇部干燥、伴有瘙痒，无充血、肿胀、鳞屑、糜烂；2级（2分）：唇部主要表现为充血、肿胀、疼痛、有少量鳞屑（小于 1/2红唇），无糜烂；3级（3分）：鳞屑较多（大1/2红唇） 、糜烂面小于２ｍｍ、伴有破溃流脓，疼痛，影响饮食；4级（4分）：鳞屑遍及整个红唇、糜烂面大于２ｍｍ 小于半唇；5级（5分）：疼痛、双唇部遍及鳞屑、双唇大面积糜烂。
疗效评定标准：
痊愈:皮损完全消退，症状消失，疗效指数≥95%；
显效:皮损大部分消退，症状明显减轻，95% ＞疗效指数60%；
有效:皮损部分消退，症状有所改善，60%＞ 疗效指数≥20%；
无效:皮损消退不明显，症状未见减轻或反见恶化，疗效指数 ＜ 20%。
疗效指数 = (治疗前评分 － 治疗后评分) /治疗前评分 ×100%
结果
3个疗程后统计，治疗组中痊愈27例，显效8例，有效3例，无效2例，治愈率67.5%，总有效率95%。
3个疗程后统计，对照组中痊愈7例，显效10例，有效6例，无效12例，治愈率20%，总有效率65.71%。
以上结果显示治愈率及有效率治疗者明显大于对照组。
典型病例
李某,女,9岁,以“口唇及唇周红肿干燥伴瘙痒脱屑1月”为主诉。患者诉口唇干燥，时有瘙痒,常以舌舔唇,以凉水润唇,但症状未明显改善,反而逐渐加重;有偏食习惯,不喜吃青菜，大便偏干， 2～3日一行。刻下症见口唇及唇周一圈红肿、干燥,部分皮肤开裂,伴有少量鳞屑，疼痛。予每次饭后用温水清洗,每日3次，每次1-2g，均匀涂抹于患处本发明膏剂，嘱患者饮食清淡,多食用蔬菜水果,保持大便通畅，避免日晒，改正舔唇咬唇的不良习惯。2个疗程后复诊,口唇 、唇周红肿干燥鳞屑消退，嘱继用2个疗程,3个月随访未再复发。
本发明膏药纯中药配制，最大程度保留了各个药材的药用功效，具有清热解毒，消肿止痛，祛风止痒之功效，可直接作用于病变部位，可显著减轻患者皮损红肿瘙痒程度、改善皮损面积、皮损表现、促进皮损愈合，具有良好的治疗作用，用药安全，是治疗唇炎药物上的创新，适用于唇炎临床治疗与护理的推广应用，经济和社会效益显著。
Claims (5)
1.一种治疗唇炎的外用药膏，其特征是：由以下重量份数计的：茜草炭60-80份、黄连30-50份、冬瓜子油300-400份、白及9-15份、槐花15-20份和蜂蜡60-80份制成；
其中，（1）将黄连、白及、槐花混合在一起，加混合药物重量7-10倍的水，浸泡1h，武火煎沸，改为文火煎煮30-60min，过滤，得第一次滤液，药渣加其重量7-10倍的水，武火煎沸，改为文火煎煮30-60min，过滤，得第二次滤液，药渣加其重量7-10倍的水，武火煎沸，改为文火煎煮30-60min，过滤，得第三次滤液，合并3次滤液，得提取液；
（2）将提取液在冷冻干燥机中浓缩，得到原提取液体积25%的提取液浸膏；
（3）将茜草放在无烟炭火中烧，烧至尚冒青烟、外面焦里面未焦，成茜草炭，研磨成过100-120目的茜草炭细粉；
（4）将蜂蜡在70-80℃水浴中加热熔融；
（5）将提取液浸膏、茜草炭细粉和冬瓜子油混合均匀，再加入熔融的蜂蜡，搅拌均匀，0-4℃冷却12小时，分装，密封保存，即为成品。
2.根据权利要求1所述的治疗唇炎的外用药膏，其特征是：由以下重量份数计的：茜草炭65-75份、黄连35-45份、冬瓜子油320-380份、白及10-14份、槐花16-18份和蜂蜡65-75份制成。
3.根据权利要求1所述的治疗唇炎的外用药膏，其特征是：由以下重量份数计的：茜草炭60份、黄连30份、冬瓜子油300份、白及9份、槐花15份和蜂蜡60份制成。
4.根据权利要求1所述的治疗唇炎的外用药膏，其特征是：由以下重量份数计的：茜草炭70份、黄连40份、冬瓜子油350份、白及12份、槐花17.5份和蜂蜡70份制成。
5.根据权利要求1所述的治疗唇炎的外用药膏，其特征是：由以下重量份数计的：由以下重量份数计的：茜草炭80份、黄连50份、冬瓜子油400份、白及15份、槐花20份和蜂蜡80份制成。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811114075.7A CN108853346B (zh) | 2018-09-25 | 2018-09-25 | 一种治疗唇炎的外用药膏 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811114075.7A CN108853346B (zh) | 2018-09-25 | 2018-09-25 | 一种治疗唇炎的外用药膏 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108853346A true CN108853346A (zh) | 2018-11-23 |
| CN108853346B CN108853346B (zh) | 2021-03-12 |
Family
ID=64324770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811114075.7A Active CN108853346B (zh) | 2018-09-25 | 2018-09-25 | 一种治疗唇炎的外用药膏 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108853346B (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991292A (zh) * | 2020-09-10 | 2020-11-27 | 大连医科大学 | 一种黄连唇膏及其制备工艺与应用 |
| CN113648373A (zh) * | 2021-08-20 | 2021-11-16 | 河南中医药大学第一附属医院 | 一种治疗慢性唇炎的中药药用唇膏组合物及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302678A (zh) * | 2011-09-15 | 2012-01-04 | 何大明 | 一种皮膜修复药 |
| CN106620539A (zh) * | 2017-02-07 | 2017-05-10 | 邹琳 | 治疗皮肤病的外用药膏、制备方法及其应用 |
| CN106924378A (zh) * | 2017-03-27 | 2017-07-07 | 上海中医药大学附属岳阳中西医结合医院 | 一种防治和/或治疗慢性唇炎的中草药唇膏 |
| CN107184502A (zh) * | 2017-04-21 | 2017-09-22 | 钦州学院 | 一种药用口红及其制备方法 |
-
2018
- 2018-09-25 CN CN201811114075.7A patent/CN108853346B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302678A (zh) * | 2011-09-15 | 2012-01-04 | 何大明 | 一种皮膜修复药 |
| CN106620539A (zh) * | 2017-02-07 | 2017-05-10 | 邹琳 | 治疗皮肤病的外用药膏、制备方法及其应用 |
| CN106924378A (zh) * | 2017-03-27 | 2017-07-07 | 上海中医药大学附属岳阳中西医结合医院 | 一种防治和/或治疗慢性唇炎的中草药唇膏 |
| CN107184502A (zh) * | 2017-04-21 | 2017-09-22 | 钦州学院 | 一种药用口红及其制备方法 |
Non-Patent Citations (3)
| Title |
|---|
| 张守仪著: "《女性的资本》", 31 July 2007, 中国妇女出版社 * |
| 赵银安等: "黄连外用治疗舌舔皮炎", 《中国民间疗法》 * |
| 邹梅等: "中药治疗糜烂型唇炎临床观察", 《陕西中医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991292A (zh) * | 2020-09-10 | 2020-11-27 | 大连医科大学 | 一种黄连唇膏及其制备工艺与应用 |
| CN113648373A (zh) * | 2021-08-20 | 2021-11-16 | 河南中医药大学第一附属医院 | 一种治疗慢性唇炎的中药药用唇膏组合物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108853346B (zh) | 2021-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103463297B (zh) | 一种治疗阴囊湿疹的中药组合物及其制备方法和用途 | |
| CN103385993B (zh) | 一种治疗胃溃疡的中药制剂及制备方法 | |
| CN102309687B (zh) | 一种治疗咽喉炎的药物 | |
| CN108853346A (zh) | 一种治疗唇炎的外用药膏 | |
| CN105535495B (zh) | 一种培元固本治疗食管癌的中药组合物及制备方法 | |
| CN103656581B (zh) | 治疗冻疮的中药组合物及制备方法 | |
| CN104547250A (zh) | 一种抑制癌细胞扩散的中药组合物及其制备方法 | |
| CN103877384B (zh) | 一种治疗直肠癌的中药制剂及制备方法 | |
| CN103705692B (zh) | 一种治疗急性胃肠炎的中药制剂 | |
| CN103860976B (zh) | 一种治疗婴幼儿皮炎的药物组合物 | |
| CN103735999B (zh) | 一种治疗痛风的中药制剂及制备方法 | |
| CN101647938B (zh) | 一种治疗烧烫伤的药物及其制备方法 | |
| CN105641329A (zh) | 一种用于阑尾炎术后护理的中药组合物 | |
| CN104258273A (zh) | 一种治疗胃溃疡的中药 | |
| CN104888172B (zh) | 治疗过敏性咳嗽的姜葱止咳制剂及应用 | |
| CN104491537A (zh) | 一种治疗风湿性心脏病的中药组合物 | |
| CN103893509B (zh) | 一种治疗过敏性鼻炎的药物及制备方法 | |
| CN115607646A (zh) | 一种治疗复发性口腔溃疡和慢性咽喉炎的组合物及制备法 | |
| CN115671249A (zh) | 一种治疗胃食管反流病的中药合剂 | |
| CN103735820B (zh) | 一种治疗肺脓肿和肺气喘的药物组合物 | |
| CN103816395A (zh) | 治疗过敏性紫癜的中药 | |
| CN112691160A (zh) | 一种治疗咽喉炎的中药制剂 | |
| CN103520620A (zh) | 一种治疗脾胃虚弱型慢性胃炎的中药制剂及制备方法 | |
| CN102302600A (zh) | 一种解烟毒及醉烟的中药药物 | |
| CN112546175A (zh) | 一种治疗胃溃疡的纯中药透皮擦剂及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |