CN108851089A - Alleviate the tablet and its preparation process of physical fatigue - Google Patents

Alleviate the tablet and its preparation process of physical fatigue Download PDF

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Publication number
CN108851089A
CN108851089A CN201811062445.7A CN201811062445A CN108851089A CN 108851089 A CN108851089 A CN 108851089A CN 201811062445 A CN201811062445 A CN 201811062445A CN 108851089 A CN108851089 A CN 108851089A
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parts
weight
tablet
physical fatigue
alleviating
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沈方雄
何静仁
王林元
刘月环
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention discloses a kind of tablets for alleviating physical fatigue, are mainly prepared from the following raw materials in parts by weight tablet：400-500 parts of taurine, 90-110 parts of caffeine, 140-160 parts of l-Lysine hydrochloride, 45-55 parts of inositol, 30-40 parts of niacinamide, vitamin B64-6 parts.The invention also discloses a kind of preparation processes of tablet for alleviating physical fatigue.Tablet is made in health care product by initiative of the invention, extracts taurine and caffeine from natural materials, and highly-safe in artificial synthesized, the product of preparation can significantly alleviate physical fatigue.

Description

Alleviate the tablet and its preparation process of physical fatigue
Technical field
The present invention relates to food technology fields.It is more particularly related to it is a kind of alleviate physical fatigue tablet and Its preparation process.
Background technique
As rhythm of life is constantly accelerated, people's body overload operation, physical strength is on a declining curve, will lead to body for a long time Body resistance and immunity degradation.To alleviate physical fatigue, improves people's sub-health state, occur many healthy medicated wines in the market And health drink.Present young people wishes to improve constitution but to healthy medicated wine and health drink presentation resistance mood, it is believed that Liquid medicine contains alcohol, and beverage contains sugar mostly, and long-term drinking is not conducive to good health.
Summary of the invention
It is an object of the invention to solve at least the above problems, and provide the advantages of at least will be described later.
It is a still further object of the present invention to provide a kind of tablet and its preparation process for alleviating physical fatigue, initiative will Tablet is made in health care product, and taurine and caffeine are extracted from natural materials, highly-safe in artificial synthesized, the product energy of preparation Enough significant alleviation physical fatigues.
In order to realize these purposes and other advantages according to the present invention, a kind of tablet for alleviating physical fatigue is provided, Mainly it is prepared from the following raw materials in parts by weight tablet：400-500 parts of taurine, 90-110 parts of caffeine, l-Lysine hydrochloride 140-160 parts, 45-55 parts of inositol, 30-40 parts of niacinamide, vitamin B64-6 parts.
Preferably, mainly it is prepared from the following raw materials in parts by weight tablet：400-500 parts of taurine, caffeine 90- 110 parts, 140-160 parts of l-Lysine hydrochloride, 45-55 parts of inositol, 30-40 parts of niacinamide, vitamin B64-6 parts, L-carnitine 90-110 parts, vitamin B120.004-0.006 parts, vitamin B28-12 parts.
Preferably, the tablet is chewable tablets.
Preferably, mainly it is prepared from the following raw materials in parts by weight chewable tablets：460 parts of taurine, 100 parts of caffeine, 150 parts of l-Lysine hydrochloride, 50 parts of inositol, 35 parts of niacinamide, vitamin B65 parts, 100 parts of L-carnitine, vitamin B12 0.005 part, vitamin B210 parts.
It preferably, further include the auxiliary material of 250-350 parts by weight.
A kind of preparation process of tablet that alleviating physical fatigue, the raw material of above-mentioned parts by weight is sieved, powder is mixed to obtain, Pelletized with the ethanol water of powder gross weight 20%, dry, auxiliary material is sieved by whole grain, total mix, tabletting, bottling to get.
Preferably, the raw material of above-mentioned parts by weight is crossed into 80 meshes, mixing 30min obtains powder, with powder gross weight 20% 85wt.% ethanol water granulation, cross 20 meshes, dry, 350-450 parts by weight auxiliary material is crossed 80 meshes, total mix by whole grain 5min, tabletting, bottling to get.
Preferably, the preparation method of the taurine is：Fish-bone is processed into fishbone dust, the distillation of 2 times of weight is added Water, constant temperature decocts 2h at 100 DEG C, filtering, and filter residue is added etc. to the distilled water of weight, and constant temperature decocts 2h at 100 DEG C, again mistake Filter merges filtrate twice, and concentrated by rotary evaporation to solid content is higher than 50%, the ethyl alcohol of the weight such as addition into concentrate, then Be added protease, adjust pH to 8,40 DEG C of heating water bath 2h, 100 DEG C of water-bath enzyme deactivations, centrifugal filtering liquid, adjust pH to 3, go to deacidify Property albumen precipitation, adjust pH to 10, removal basic protein precipitating, be added 10 times of weight distilled water, adjust pH to 5, must dilute Dilution is injected light room by liquid, by etc. the 0.25wt.%NaCl solution of weight inject dense room, by etc. the distilled water of weight inject Pole room, control light room, dense room water flow be 400000L/h, control pole room water flow be 200L/h, with the speed of 2V/min Increase voltage to 20V, when electric current no longer reduces, adjusts voltage, electric current 0, dilution carries out cationic exchange by treated Processing, collect efflux, be concentrated under reduced pressure, freeze-drying to get.
Preferably, the preparation method of the caffeine is：Green bamboo snake is processed into green bamboo snake powder, 10 times of weight are added Distilled water, adding mass ratio is 1:The mixture of 1 CaO and MgO, stirring to paste are dried, and crush, 20 times of quality are added Volume ratio be 6:1 ethyl alcohol and [BMIM]+[BH4]-Mixed solution extract 2 times, Extracting temperature is 80 DEG C, and extraction time is 2h, combined extract are distilled ethyl alcohol and [BMIM]+[BH4]-It steams, concentrated by rotary evaporation to solid content is higher than 50%, with just Hexane extraction, the sodium chloride solution of 5wt.% is added in water phase, is extracted with chloroform, merges organic phase, is concentrated under reduced pressure, and freezing is dry It is dry to get.
The present invention is include at least the following beneficial effects：
The first, tablet is made in raw material by the present invention, is had initiative, is overcome tradition and be prepared into caused by beverage or liquid medicine Prejudice is taken, formula functional of the invention, additive are few, have excellent antifatigue effect；Chewable tablets promotes drug to exist Intracorporal dissolution and absorption, for the selection of more preferably tablet；The auxiliary material for adding the amount can correct the dose and specification of major ingredient；This Invention is overcome using the ethanol water granulation of the 85wt.% of powder gross weight 20% and is prepared tablet by taurine and caffeine Technical difficulty；
The second, the present invention uses natural product extraction taurine, selects fish-bone to extract, avoids conventional marine organisms from being made black Color product causes the later period using a large amount of sour acidolysis, and strong acid hydrolysis is easily destroyed taurine, the taurine molecule being present in fish-bone It is not easy free isolation, decoction makes the free isolation of taurine, enters solution, and content of taurine is low, still contains a large amount of amino acid, more Peptide, soluble protein, then digested, enzyme deactivation, the taurine in the assisted extraction fish-bone of proteinase activity center, it adjusts pH and goes Except acid albumen precipitation and basic protein precipitate, the anion-permeable cavity block of light room enters dense room, but dense indoor anion is not Anode membrane can be penetrated, therefore stays in dense interior；Cation is migrated to cathode, and enters dense room by anode membrane, and dense indoor cation is but Cavity block cannot be penetrated, therefore is stayed in dense room, the salt ionic concentration of dilution is gradually small in light room, and electric current is gradually decrease to stablize, The purity of taurine can reach 97%；
Third, the present invention use natural product extraction caffeine, select non-fermented tea green bamboo snake, content of caffeine is high, CaO It is reacted with MgO with the gallic acid that tannic acid in green bamboo snake or hydrolysis generate and generates the calcium salt being impermissible for or magnesium salts solidification precipitating, Keep caffeine free, it is high compared to single extractant extracting caffeine yield with the compounding of acetone and ionic liquid, electrolysis is added Matter sodium chloride increases polarity, and extraction solution is avoided to form milkiness shape, shortens separation time.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this The research and practice of invention and be understood by the person skilled in the art.
Specific embodiment
The present invention will be further described in detail below with reference to the embodiments, to enable those skilled in the art referring to specification Text can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more The presence or addition of a other elements or combinations thereof.
It should be noted that experimental method described in following embodiments is unless otherwise specified conventional method, institute Reagent and material are stated, unless otherwise specified, is commercially obtained.
<Example 1>
A kind of tablet for alleviating physical fatigue, is mainly prepared from the following raw materials in parts by weight tablet：Taurine 400mg, Caffeine 90mg, l-Lysine hydrochloride 140mg, inositol 45mg, niacinamide 30mg, vitamin B64mg, starch, starch slurry, cunning Mountain flour etc. complements to 1200mg.
The raw material of above-mentioned parts by weight is sieved, powder is mixed to obtain, is pelletized, is done with the ethanol water of powder gross weight 20% Dry, auxiliary material is sieved by whole grain, total mix, tabletting, bottles to get oral ordinary tablet.
The raw material standard of taurine is：GB 14759-2010 national food safety standard food additives taurine, coffee The raw material standard of cause is：GB 14758-2010 national food safety standard food additives caffeine, the original of l-Lysine hydrochloride Material standard is：GB 1903.1-2015 national food safety standard food enrichment l-Lysine hydrochloride, the raw material of inositol Standard is：The Ministry of Public Health's No. 19 bulletin in 2011, the raw material standard of niacinamide are：《Chinese Pharmacopoeia》Two, the original of vitamin B6 Material standard is：GB 14753-2010 national food safety standard food additives vitamin B6 (puridoxine hydrochloride), manufactured production Product 0.6g/ piece, 2 times a day, 1 tablet once.
<Example 2>
A kind of tablet for alleviating physical fatigue, is mainly prepared from the following raw materials in parts by weight tablet：Taurine 500mg, Caffeine 110mg, l-Lysine hydrochloride 160mg, inositol 55mg, niacinamide 40mg, vitamin B66mg, starch, sucrose, paste Essence, acrylic resin etc. complement to 1200mg.
The raw material of above-mentioned parts by weight is sieved, powder is mixed to obtain, is pelletized, is done with the ethanol water of powder gross weight 20% Dry, auxiliary material is sieved by whole grain, total mix, tabletting, bottles to get enteric coatel tablets.
The raw material standard of taurine is：GB 14759-2010 national food safety standard food additives taurine, coffee The raw material standard of cause is：GB 14758-2010 national food safety standard food additives caffeine, the original of l-Lysine hydrochloride Material standard is：GB 1903.1-2015 national food safety standard food enrichment l-Lysine hydrochloride, the raw material of inositol Standard is：The Ministry of Public Health's No. 19 bulletin in 2011, the raw material standard of niacinamide are：《Chinese Pharmacopoeia》Two, the original of vitamin B6 Material standard is：GB 14753-2010 national food safety standard food additives vitamin B6 (puridoxine hydrochloride), manufactured production Product 0.6g/ piece, 2 times a day, 1 tablet once.
<Example 3>
A kind of tablet for alleviating physical fatigue, is mainly prepared from the following raw materials in parts by weight chewable tablets：Taurine 460mg, caffeine 100mg, l-Lysine hydrochloride 150mg, inositol 50mg, niacinamide 35mg, vitamin B65mg, magnesium stearate Complement to 1200mg.
The raw material of above-mentioned parts by weight is sieved, powder is mixed to obtain, is pelletized, is done with the ethanol water of powder gross weight 20% Dry, auxiliary material is sieved by whole grain, total mix, tabletting, bottles to get chewable tablets.
The raw material standard of taurine is：GB 14759-2010 national food safety standard food additives taurine, coffee The raw material standard of cause is：GB 14758-2010 national food safety standard food additives caffeine, the original of l-Lysine hydrochloride Material standard is：GB 1903.1-2015 national food safety standard food enrichment l-Lysine hydrochloride, the raw material of inositol Standard is：The Ministry of Public Health's No. 19 bulletin in 2011, the raw material standard of niacinamide are：《Chinese Pharmacopoeia》Two, the original of vitamin B6 Material standard is：GB 14753-2010 national food safety standard food additives vitamin B6 (puridoxine hydrochloride), manufactured production Product 0.6g/ piece, 2 times a day, 1 tablet once.
<Example 4>
A kind of tablet for alleviating physical fatigue, is mainly prepared from the following raw materials in parts by weight tablet：Taurine 400mg, Caffeine 90mg, l-Lysine hydrochloride 140mg, inositol 45mg, niacinamide 30mg, vitamin B64mg, L-carnitine 90mg, dimension Raw element B120.004mg, vitamin B28mg, starch, citric acid, malic acid, talcum powder complement to 1200mg.
The raw material of above-mentioned parts by weight is sieved, powder is mixed to obtain, is pelletized, is done with the ethanol water of powder gross weight 20% Dry, auxiliary material is sieved by whole grain, total mix, tabletting, bottles to get effervescent tablet.
The raw material standard of taurine is：GB 14759-2010 national food safety standard food additives taurine, coffee The raw material standard of cause is：GB 14758-2010 national food safety standard food additives caffeine, the original of l-Lysine hydrochloride Material standard is：GB 1903.1-2015 national food safety standard food enrichment l-Lysine hydrochloride, the raw material of inositol Standard is：The Ministry of Public Health's No. 19 bulletin in 2011, the raw material standard of niacinamide are：《Chinese Pharmacopoeia》Two, the original of vitamin B6 Material standard is：GB 14753-2010 national food safety standard food additives vitamin B6 (puridoxine hydrochloride), manufactured production Product 0.6g/ piece, 2 times a day, 1 tablet once.
<Example 5>
A kind of tablet for alleviating physical fatigue, is mainly prepared from the following raw materials in parts by weight tablet：Taurine 500mg, Caffeine 110mg, l-Lysine hydrochloride 160mg, inositol 55mg, niacinamide 40mg, vitamin B66mg, L-carnitine 110mg, Vitamin B120.006mg, vitamin B212mg, starch, sucrose, cane sugar powder, mannitol etc. complement to 1200mg.
The raw material of above-mentioned parts by weight is sieved, powder is mixed to obtain, is pelletized, is done with the ethanol water of powder gross weight 20% Dry, auxiliary material is sieved by whole grain, total mix, tabletting, bottles to get buccal tablet.
The raw material standard of taurine is：GB 14759-2010 national food safety standard food additives taurine, coffee The raw material standard of cause is：GB 14758-2010 national food safety standard food additives caffeine, the original of l-Lysine hydrochloride Material standard is：GB 1903.1-2015 national food safety standard food enrichment l-Lysine hydrochloride, the raw material of inositol Standard is：The Ministry of Public Health's No. 19 bulletin in 2011, the raw material standard of niacinamide are：《Chinese Pharmacopoeia》Two, the original of vitamin B6 Material standard is：GB 14753-2010 national food safety standard food additives vitamin B6 (puridoxine hydrochloride), manufactured production Product 0.6g/ piece, 2 times a day, 1 tablet once.
<Example 6>
A kind of tablet for alleviating physical fatigue, is mainly prepared from the following raw materials in parts by weight chewable tablets：Taurine 460mg, caffeine 100mg, l-Lysine hydrochloride 150mg, inositol 50mg, niacinamide 35mg, vitamin B65mg, L-carnitine 100mg, vitamin B120.005mg, vitamin B210mg, magnesium stearate complement to 1200mg.
The raw material of above-mentioned parts by weight is sieved, powder is mixed to obtain, is pelletized, is done with the ethanol water of powder gross weight 20% Dry, auxiliary material is sieved by whole grain, total mix, tabletting, bottles to get chewable tablets.
The raw material standard of taurine is：GB 14759-2010 national food safety standard food additives taurine, coffee The raw material standard of cause is：GB 14758-2010 national food safety standard food additives caffeine, the original of l-Lysine hydrochloride Material standard is：GB 1903.1-2015 national food safety standard food enrichment l-Lysine hydrochloride, the raw material of inositol Standard is：The Ministry of Public Health's No. 19 bulletin in 2011, the raw material standard of niacinamide are：《Chinese Pharmacopoeia》Two, the original of vitamin B6 Material standard is：GB 14753-2010 national food safety standard food additives vitamin B6 (puridoxine hydrochloride), manufactured production Product 0.6g/ piece, 2 times a day, 1 tablet once.
<Example 7>
A kind of tablet for alleviating physical fatigue, is formulated and preparation method is with example 6, the difference is that, the preparation side of taurine Method is：Fish-bone is processed into fishbone dust, the distilled water of 2 times of weight is added, constant temperature decocts 2h at 100 DEG C, and filter residue is added for filtering Etc. weight distilled water, constant temperature decocts 2h at 100 DEG C, filters again, merges filtrate twice, concentrated by rotary evaporation to solid content It higher than 50%, the ethyl alcohol of weight such as is added into concentrate, adds protease, adjust pH to 8,40 DEG C of heating water bath 2h, 100 DEG C water-bath enzyme deactivation, centrifugal filtering liquid adjust pH to 3, removal acidic protein precipitating, adjust pH to 10, removal basic protein precipitating, Be added the distilled water of 10 times of weight, adjust pH to 5, obtain dilution, dilution is injected into light room, by etc. weight 0.25wt.% NaCl solution injects dense room, by etc. the distilled water of weight inject pole room, control light room, the water flow of dense room is 400000L/h, control The water flow of pole room processed is 200L/h, increases voltage to 20V with the speed of 2V/min, when electric current no longer reduces, adjusts voltage, electricity Stream is 0, and treated dilution is carried out cation exchange treatment, efflux is collected, is concentrated under reduced pressure, freeze-drying to get.
Identified, the infrared absorption of taurine made from example 7 and the infrared absorption of taurine standard items are completely the same, 3209cm-1、3048cm-1Place is N-H stretching vibration, 2969cm-1Place is C-H stretching vibration, 1617cm-1、1585cm-1、 1513cm-1、1215cm-1、1182cm-1Place is C-S, S=O stretching vibration.
The color for the taurine that example 7 is extracted is that white to cheese color crystallizes, yield 93%, purity 97%, yield For 3.8g/kg fish-bone.
The yield of example 7 is apparently higher than conventional chemical synthesis method (2- ethylaminoethanol synthetic method 83%, cystamine oxidative synthesis Method 87.6%, N- vinyl alkyl amide synthetic method 89%).
<Example 8>
A kind of tablet for alleviating physical fatigue, is formulated and preparation method is with example 6, the difference is that, the preparation side of caffeine Method is：Green bamboo snake is processed into green bamboo snake powder, the distilled water of 10 times of weight is added, adding mass ratio is 1:1 CaO and MgO Mixture, stirring dries to paste, crushes, and the volume ratio that 20 times of quality are added is 6:1 ethyl alcohol and [BMIM]+[BH4]-'s Mixed solution extracts 2 times, and Extracting temperature is 80 DEG C, extraction time 2h, and combined extract is distilled ethyl alcohol and [BMIM]+ [BH4]-It steams, concentrated by rotary evaporation to solid content is higher than 50%, and with n-hexane extraction, the chlorination of 5wt.% is added in water phase Sodium solution is extracted with chloroform, merge organic phase, be concentrated under reduced pressure, freeze-drying to get.
Identified, caffeine infrared absorption made from example 8 and the infrared absorption of caffeine standards are completely the same, 2954cm-1Place is CH3C-H stretching vibration, 1430cm-1、3110cm-1Place is N-CH3Upper C-H bending vibration, 1664cm-1、 1702cm-1Place is>CO stretching vibration, 1280cm-1Place is C-N stretching vibration.
The color for the caffeine that example 8 is extracted is white crystals, and yield is 188mg/5g green bamboo snake.
<Example 9>
A kind of tablet for alleviating physical fatigue, is formulated and preparation method is with example 6, the difference is that,
The preparation method of taurine is：Fish-bone is processed into fishbone dust, the distilled water of 2 times of weight, constant temperature at 100 DEG C is added Decoct 2h, the distilled water of weight is added etc. in filter residue by filtering, and constant temperature decocts 2h at 100 DEG C, filters again, merges filter twice Liquid, concentrated by rotary evaporation to solid content are higher than 50%, and into concentrate, the ethyl alcohol of the weight such as addition, adds protease, adjust PH to 8,40 DEG C of heating water bath 2h, 100 DEG C of water-bath enzyme deactivations, centrifugal filtering liquid adjust pH to 3, and removal acidic protein precipitating is adjusted PH to 10, removal basic protein precipitating, is added the distilled water of 10 times of weight, adjusts pH to 5, obtain dilution, dilution is injected Light room, by etc. the 0.25wt.%NaCl solution of weight inject dense room, by etc. the distilled water of weight inject pole room, control light room, dense The water flow of room is 400000L/h, and the water flow for controlling pole room is 200L/h, increases voltage to 20V, electricity with the speed of 2V/min When stream no longer reduces, voltage, electric current 0 are adjusted, by treated, dilution carries out cation exchange treatment, efflux is collected, Be concentrated under reduced pressure, freeze-drying to get；
The preparation method of caffeine is：Green bamboo snake is processed into green bamboo snake powder, the distilled water of 10 times of weight is added, adds Mass ratio is 1:The mixture of 1 CaO and MgO, stirring to paste are dried, and are crushed, and the volume ratio that 20 times of quality are added is 6:1 Ethyl alcohol and [BMIM]+[BH4]-Mixed solution extract 2 times, Extracting temperature be 80 DEG C, extraction time 2h, combined extract, It distills ethyl alcohol and [BMIM]+[BH4]-It steams, concentrated by rotary evaporation to solid content is higher than 50%, with n-hexane extraction, in water phase It is middle be added 5wt.% sodium chloride solution, extracted with chloroform, merge organic phase, be concentrated under reduced pressure, freeze-drying to get.
<Comparative example 1>
Using alcohol extracting sublimed method in green bamboo snake extracting caffeine：5g tealeaves is taken, the filter paper casing of Soxhlet extractor is packed into It is interior, the ethyl alcohol of 40mL95% is added in 250mL round-bottomed flask, heating water bath makes hot ethanol repeatedly dissolve the coffee in tealeaves Cause, extraction times 90min stop heating.After slightly cooling down, repacks Soxhlet extraction device into distilling apparatus, remain 5 in cucurbit Until~10mL blackish green extracting solution.Raffinate is poured into evaporating dish, adds 3~4g calcium lime powder, is evaporated in water-bath.Then will Evaporating dish is moved on asbestos gauge and is heated, and by a thorn, there are many circle filter paper of aperture to cover on evaporating dish, then covers a drying Glass funnel (a little cotton of filler neck part plug), heating sublimation.When occurring white, needle-shaped crystals on filter paper, make rate of sublimation Slow down as far as possible, to improve crystallization purity.When brown fume occurs in glass funnel, indicates that distillation finishes, stop heating.It is cooling Afterwards, it opens funnel and filter paper, collects on filter paper and the caffeine of inner wall of hopper.
In comparative example 2, the siphon pipe price of Soxhlet extractor is higher, is easy breakage, the color of the caffeine extracted It is impure for yellow crystal, it is recrystallized, yield is 123mg/5g green bamboo snake.
<Comparative example 2>
A kind of tablet for alleviating physical fatigue, is formulated and preparation method is with example 8, the difference is that, the preparation of caffeine Raw material is the Iron Guanyin or Dragon Well tea of equivalent.
For test result it is found that the yield of Iron Guanyin is 88mg/5g Iron Guanyin, imperial well yield is 65mg/5g Dragon Well tea, remote low The yield 188mg/5g green bamboo snake of green bamboo snake in example 8.
<Alleviate effort trial>
Selecting weight is mouse 160 of 18~22g, half male and half female.Mouse is randomly divided into four big groups, per big group 40 It only, is daily 0.2g/10g to mouse administered volume through stomach perfusion, successive administration 20d, test group 1 feeds the preparation of example 3 Product, test group 2 feed the product of the preparation of example 6, and control group feeds commercially available Maotai-flavor liquor, and blank group feeds water.Last perfusion It is separated into four groups, 10 mouse of every group for every group afterwards.When major group of mouse to be carried out according to four groups to swimming with a load attached to the body respectively Between, serum urea nitrogen, hepatic glycogen and 4 index determinings of Serum Creatine Kinase of Patients, the difference of indices between comparative group.
1.1 walking weight load
Mouse last perfusion is placed in swimming trunk, depth of water 50cm, water temperature (25 ± 0.5) DEG C, by 5% body of root of the tail portion load The mouse of weight lead counterweight is placed in swimming trunk went swimming, and record is unable to emersion water to head whole submerged 10s since swimming The time in face is the mice burden swimming time as mouse longest swimming time.Test result is as shown in table 1, it can be seen that 2 mouse power of test group exhausts swimming, and obviously performance is the most active, and 1 mouse power of test group exhausts swimming, and obviously performance is more active, tests 1,2 swimming times of group are longer than control group (P < 0.05), and considerably longer than blank group (P < 0.01).
The measurement of 1.2 serum urea nitrogens
After mouse last perfusion, depth of water 50cm, water temperature (25 ± 0.5) DEG C, mouse not swimming with a load attached to the body 90min, rest 60min After take a blood sample, by kit method measure urea in serum nitrogen content.Test result is as shown in table 1, it can be seen that test group 1,2 Urea nitrogen is lower than control group (P < 0.01) in mice serum, and substantially less than blank group (P < 0.01).
The measurement of 1.3 hepatic glycogen
After mouse last perfusion 30min, mouse is put to death, liver is taken to be blotted after physiological saline rinses with filter paper, it is accurate to claim It takes and measures hepatic glycogen content by kit method after liver.Test result is as shown in table 1, it can be seen that test group 1,2 mouse blood Glycogen is higher than control group (P < 0.01) in clear, and is significantly higher than blank group (P < 0.01).
The measurement of creatine phosphokinase in 1.4 serum
It takes a blood sample after mouse last perfusion 30min, by creatine phosphokinase vigor in kit method measurement serum.Test knot Fruit is as shown in table 1, it can be seen that creatine phosphokinase is lower than control group (P < 0.01) in test group 1,2 mice serums, and shows It writes and is lower than blank group (P < 0.01).
Table 1
<Cell proliferation test>
It selects newborn mice (< is for 24 hours), puts to death animal, separate osteoblast-like cells group, cultured osteoblast-like cells in vitro to shape Stablize, be in fiber bundle-like, triangle, cell connects each other closely.By osteoblast with 1 × 105A/mL cell density, every hole 800 μ inoculation is added culture solution (containing vitamin C and sodium β-glycerophosphate), is divided into four groups of inoculations after cell is adherent, prepared by example 6 Product, example 9 prepare product, taurine and caffeine compound preparation (mass ratio 5:1), blank group, every 3d change liquid 1 Secondary, 18d exhausts culture solution, rinses, and ethanol solution is fixed, and rinses, and dyes, and is incubated for, and rinses, microscopically observation, every group random It selects 5 visuals field, to count calcium scoring quantity under low power lens.A large amount of round coloring calcium are formed after example 6,9 dyes under microscope Change tubercle, sharpness of border, commercially available Maotai-flavor liquor and blank group are less.Test result is as shown in table 3, it can be seen that example 6,9 Be apparently higher than the compound preparation and blank group (P < 0.05) of taurine and caffeine to the calcification of osteoblast, promote at Bone cell proliferation.
Table 2
Number of devices and treatment scale described herein are for simplifying explanation of the invention.To application of the invention, Modifications and variations will be readily apparent to persons skilled in the art.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited In specific details and example shown and described herein.

Claims (9)

1. a kind of tablet for alleviating physical fatigue, which is characterized in that be mainly prepared from the following raw materials in parts by weight tablet：Ox sulphur It is 400-500 parts sour, 90-110 parts of caffeine, 140-160 parts of l-Lysine hydrochloride, 45-55 parts of inositol, 30-40 parts of niacinamide, dimension Raw element B64-6 parts.
2. alleviating the tablet of physical fatigue as described in claim 1, which is characterized in that mainly by the raw material of following parts by weight Tablet is made：400-500 parts of taurine, 90-110 parts of caffeine, 140-160 parts of l-Lysine hydrochloride, 45-55 parts of inositol, cigarette 30-40 parts of amide, vitamin B64-6 parts, 90-110 parts of L-carnitine, vitamin B120.004-0.006 parts, vitamin B2 8-12 parts.
3. alleviating the tablet of physical fatigue as described in claim 1, which is characterized in that the tablet is chewable tablets.
4. alleviating the tablet of physical fatigue as described in claim 1, which is characterized in that mainly by the raw material of following parts by weight Chewable tablets is made：460 parts of taurine, 100 parts of caffeine, 150 parts of l-Lysine hydrochloride, 50 parts of inositol, 35 parts of niacinamide, dimension life Plain B65 parts, 100 parts of L-carnitine, vitamin B120.005 part, vitamin B210 parts.
5. alleviating the tablet of physical fatigue as claimed in claim 4, which is characterized in that further include the auxiliary of 250-350 parts by weight Material.
6. the preparation process of the tablet according to any one of claims 1 to 5 for alleviating physical fatigue, which is characterized in that will be upper The raw material sieving for stating parts by weight, mixes to obtain powder, is pelletized with the ethanol water of powder gross weight 20%, dry, whole grain will be auxiliary Material sieving, total mix, tabletting, bottling to get.
7. alleviating the preparation process of the tablet of physical fatigue as claimed in claim 6, which is characterized in that by above-mentioned parts by weight Raw material cross 80 meshes, mixing 30min obtains powder, is pelletized with the ethanol water of the 85wt.% of powder gross weight 20%, crosses 20 mesh 350-450 parts by weight auxiliary material is crossed 80 meshes by sieve, dry, whole grain, total mix 5min, tabletting, bottling to get.
8. alleviating the preparation process of the tablet of physical fatigue as claimed in claim 7, which is characterized in that the system of the taurine Preparation Method is：Fish-bone is processed into fishbone dust, the distilled water of 2 times of weight is added, constant temperature decocts 2h, filtering, by filter residue at 100 DEG C The distilled water of weight such as it is added, constant temperature decocts 2h at 100 DEG C, filters again, merges filtrate twice, concentrated by rotary evaporation to solid content Content is higher than 50%, and into concentrate, the ethyl alcohol of the weight such as addition, adds protease, adjusts pH to 8,40 DEG C of heating water baths 2h, 100 DEG C of water-bath enzyme deactivations, centrifugal filtering liquid adjust pH to 3, and removal acidic protein precipitating adjusts pH to 10, removes alkaline egg The distilled water of 10 times of weight is added in white precipitating, adjusts pH to 5, obtains dilution, dilution is injected light room, by etc. weight 0.25wt.%NaCl solution injects dense room, by etc. the distilled water of weight inject pole room, control light room, the water flow of dense room is 400000L/h, the water flow for controlling pole room is 200L/h, increases voltage to 20V with the speed of 2V/min, electric current no longer reduces When, voltage, electric current 0 are adjusted, dilution carries out cation exchange treatment by treated, collects efflux, is concentrated under reduced pressure, cold Be lyophilized it is dry to get.
9. alleviating the preparation process of the tablet of physical fatigue as claimed in claim 7, which is characterized in that the system of the caffeine Preparation Method is：Green bamboo snake is processed into green bamboo snake powder, the distilled water of 10 times of weight is added, adding mass ratio is 1:1 CaO and The mixture of MgO, stirring to paste are dried, and are crushed, and the volume ratio that 20 times of quality are added is 6:1 ethyl alcohol and [BMIM]+ [BH4]-Mixed solution extract 2 times, Extracting temperature be 80 DEG C, extraction time 2h, combined extract, distillation by ethyl alcohol with [BMIM]+[BH4]-It steams, concentrated by rotary evaporation to solid content is higher than 50%, and with n-hexane extraction, 5wt.% is added in water phase Sodium chloride solution, extracted with chloroform, merge organic phase, be concentrated under reduced pressure, freeze-drying to get.
CN201811062445.7A 2018-09-12 2018-09-12 Alleviate the tablet and its preparation process of physical fatigue Pending CN108851089A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109453130A (en) * 2018-12-25 2019-03-12 白昀易 Buccal tablet and preparation method thereof containing caffeine
CN109998106A (en) * 2019-04-11 2019-07-12 辽宁力克制药有限公司 It relieves the effect of alcohol, composition for relieving physical fatigue
CN110771901A (en) * 2019-11-01 2020-02-11 中南粮油食品科学研究院有限公司 Anti-fatigue hunger-resistant food additive and preparation method and application thereof
WO2021019434A1 (en) * 2019-07-29 2021-02-04 Neilos S.r.l. Composition for use in the prevention and/or treatment of symptoms related to tiredness and fatigue

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109453130A (en) * 2018-12-25 2019-03-12 白昀易 Buccal tablet and preparation method thereof containing caffeine
CN109998106A (en) * 2019-04-11 2019-07-12 辽宁力克制药有限公司 It relieves the effect of alcohol, composition for relieving physical fatigue
WO2021019434A1 (en) * 2019-07-29 2021-02-04 Neilos S.r.l. Composition for use in the prevention and/or treatment of symptoms related to tiredness and fatigue
CN110771901A (en) * 2019-11-01 2020-02-11 中南粮油食品科学研究院有限公司 Anti-fatigue hunger-resistant food additive and preparation method and application thereof

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