CN110101679A - Micro- effervescent tablet of seaweed sodium bicarbonate and its preparation method and application - Google Patents
Micro- effervescent tablet of seaweed sodium bicarbonate and its preparation method and application Download PDFInfo
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- CN110101679A CN110101679A CN201910401136.6A CN201910401136A CN110101679A CN 110101679 A CN110101679 A CN 110101679A CN 201910401136 A CN201910401136 A CN 201910401136A CN 110101679 A CN110101679 A CN 110101679A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Abstract
The invention discloses a kind of micro- effervescent tablets of seaweed sodium bicarbonate and its preparation method and application, component including following percentage: sodium bicarbonate 25%~50%, seawood meal 1~10%, fruit powder 5%~20%, lactose 10%~40%, mannitol 10%~40%, plant extracts 1%~15%, buffer 0.02%~5%, stevioside 0.2%~2%, lubricant 0.3%~8%, the present invention provides a kind of microvesicle effervescent tablet of similar salsoda water, compound minerals seawood meal abundant and characteristic fruit powder, and it joined buffer and plant extracts (dandelion wherein, sophora flower, Herba Lophatheri extract) mixture, so that not only content of mineral substances is abundant for the product, flavor is good, it is more economical, bioavilability is high, also there are Small side effects, alleviate gastric acid effect, more can Enough further effects for improving alleviation arthralgia and preventing gout, reducing uric acid.
Description
Technical field
The present invention relates to micro- effervescent tablets of a kind of sodium bicarbonate and its preparation method and application.
Background technique
Soda water belongs to alkalescent water, can quickly be dissolved by soda effervescent tablet.Soda water is conducive to nourishing the stomach, because of Soviet Union
Beat weak base water energy in and gastric acid.Soda water, which helps to alleviate indigestion and constipation symptom, also has that anti-oxidant, prevention skin is old
Change effect.U.S.'s " Journal of Immunology " publishes a recent studies on and claims, and drinking soda water daily helps to alleviate rheumatoid joint
The autoimmune diseases such as inflammation.U.S.'s Augusta university research person's Borrow's aokang receive doctor and its research group complete it is big
Mouse and human experimentation as a result, it has been found that, rat or Healthy People, which drink soda water not only, can promote stomach to generate more gastric acids, so as to
Preferably the eaten food of one meal of digestion, while the immune response milder of spleen (a part of immune system) can be made.But it is long
Phase takes soda water, may cause alkalosis, gently then anorexia, nausea, headache, twitch, heavy then go into a coma, especially the elderly and kidney
Popular name for patient, long-term use are easier to that alkalosis occurs.
Currently, most in the market is soda effervescent tablet, flavor is bad, and reaches dissolution by acid-base reaction；Salsoda
Water is in good taste, but price is high；Patient with gout needs anti-trioxypurine, but takes soda for a long time, can cause alkalosis, gently then anorexia, dislike
The heart, headache, twitch, heavy then go into a coma, especially the elderly and Patients With Kidney Diseases.Develop that a kind of economic value is high, non-acid-base reaction is molten
The high product of solution, bioavilability has its necessity.
Summary of the invention
It is existing to overcome the purpose of the present invention is disclosing a kind of micro- effervescent tablet of seaweed sodium bicarbonate and its preparation method and application
Defect existing for technology.
The micro- effervescent tablet of seaweed sodium bicarbonate, the component including following percentage:
Preferably, the component including following percentage:
The fruit powder is selected from one or more of green plum powder, grapefruit powder or acerola concentrate powder, papaya powder etc.；
The seawood meal is a kind of calcium content 12%, the substance containing magnesium 2.2% and other 72 kinds of minerals；
Commercially produced product can be used in the stevioside；
Commercially produced product can be used in the mannitol；
The plant extracts is the mixture of dandelion, sophora flower and Herba Lophatheri extract；
It is preferred: in the mixture of dandelion, sophora flower and Herba Lophatheri extract, the weight ratio of each component are as follows: dandelion
Extract: Flos Sophorae extract: Herba Lophatheri extract=1:0.5~1.5:0.5~1.5；
Most preferably, the weight ratio of each component are as follows:
Dandelion extract: Flos Sophorae extract: Herba Lophatheri extract=1:1:1, by Shaanxi, Sen Fu natural product company is mentioned
For；
The buffer be one of calgon, sodium phosphate, sodium dihydrogen phosphate or more than one；
The lubricant is selected from superfine silica gel powder, polyethylene glycol, sucrose fatty ester, fumaric acid, leucine, boric acid, benzene
One or more of sodium formate or sodium stearyl fumarate etc.；
The preparation method of the micro- effervescent tablet of seaweed sodium bicarbonate of the present invention, includes the following steps:
1. sodium bicarbonate is mixed with solvent, then pelletize:
The maltodextrin that the solvent is the ethanol solution that volumetric concentration is 75~90% or weight concentration is 3~10%
Solution
The method of granulating is conventional；
The weight ratio of sodium bicarbonate and solvent is 15:1~4:1
2. the sodium bicarbonate particle of acquisition and unclassified stores (except lubricant) are crossed 20 meshes, mixing respectively；
3. after polyethylene glycol crosses 80 meshes, being mixed with the product of step 2；
4. the mixed powder tabletting of step 3 can be obtained the micro- effervescent tablet of seaweed sodium bicarbonate；
Animal experiment proves that the micro- effervescent tablet of seaweed sodium bicarbonate of the invention has and alleviates arthralgia and prevention gout, drop
The effect of low uric acid can be applied to patient in need for the treatment of by way of oral, and dosage is generally 0.5~3g/ days；
It is of the invention effective to be:
The present invention provides a kind of microvesicle effervescent tablet of similar salsoda water, compounding minerals seawood meal abundant and characteristic
Fruit powder, and joined the mixture of buffer and plant extracts (dandelion, sophora flower, lophatherum gracile, extract) wherein, so that
Not only content of mineral substances is abundant, flavor is good, more economical for the product, also has Small side effects, alleviates gastric acid effect, more can be into one
The effect that the raising of step alleviates arthralgia and prevents gout, reduces uric acid.
Specific embodiment
Embodiment 1
Wherein, the plant extracts be dandelion, sophora flower and Herba Lophatheri extract mixture in, each component
Weight ratio are as follows: dandelion extract: Flos Sophorae extract: Herba Lophatheri extract=1:1:1:1, by Shaanxi Sen Fu natural product company
It provides
Production method: the granulation of 1. sodium bicarbonate: sodium bicarbonate is granulated with 85% ethanol solution；
The weight ratio of sodium bicarbonate and solvent is 5.7:1；
2. the sodium bicarbonate and unclassified stores (removing polyethylene glycol) after being granulated mix 15min after weighing, crossing 20 meshes；
3. after polyethylene glycol crosses 80 meshes, mixing 5min with 2；
4. by 3 mixed powder tabletting, every 600mg；
Embodiment 2
Wherein, the plant extracts be dandelion, sophora flower and Herba Lophatheri extract mixture in, each component
Weight ratio are as follows: dandelion extract: Flos Sophorae extract: Herba Lophatheri extract=1:1:1,
Production method:
1. sodium bicarbonate is pelletized: being granulated with the maltodextrin solution that weight concentration is 5% to sodium bicarbonate；
The weight ratio of sodium bicarbonate and solvent is 9:1；
2. the sodium bicarbonate and his material (removing sodium stearyl fumarate) after being granulated mix 15min after weighing, crossing 20 meshes；
3. after sodium stearyl fumarate crosses 40 meshes, mixing 5min with 2；
4. by 3 mixed powder tabletting, every 600mg；
Comparative example 1
Production method is with embodiment 1:
Comparative example 2
Embodiment 3
Clinical observation:
(1) clinical data
Clinical test is carried out to 245 urarthritis patients, these patients have different degrees of arthralgia, swell
Swollen symptom, and course of disease 1-3.Male 155, female 90.130 (embodiment 1:70 people for the treatment of group；Embodiment 2:60 people), control
115 (comparative example 1:60 people of group；Comparative example 2:55 people).
(2) treatment method
Control group gives comparative example 1 and comparative example 2；Treatment group takes orally Example 1 and Example 2 of the present invention,
2 times a day, 2 tablets once；Period 15 days
(3) curative effect determinate standard:
Effective: knee joint without pain, periarticular is without tenderness, and joint is without swelling, and 130 ° of range of motion.
It is effective: knee joint slightly pain, the light tenderness of periarticular, slightly swelling, 130 ° of range of motion.It is invalid: knee joint pain
Bitterly, periarticular swelling, tenderness, range of motion is less than 130 °.
(4) clinical test results are as follows:
By knowing above, the effect of product of the present invention is substantially better than control group.
Embodiment 4
Zoopery
(1) foundation of hyperuricemia model
Oxonic Acid sylvite is a kind of uricase inhibitor, can inhibit uric acid as chemical inducer and decomposes, increases internal blood
Clear uric acid level.2h presses 300mg/kg dosage intraperitoneal injection of mice with Oxonic Acid sylvite (Sigma company) before blood sampling, normally
Control group then injects isometric 0.5%CMC-Na solution.2h after administration, 5h take a blood sample from mouse orbit rear vein beard respectively, phosphorus molybdenum
Sour reduction method measures serum uric acid.The result shows that Oteracil Potassium can improve mice serum uric acid level (P < extremely significantly
0.001) Studies on Animal Models of Hyperuricemic Mice, is caused, animal blood serum uric acid level can maintain 5h in model.The method is sensitive easy, again
Renaturation is good, has been commonly used to the inhibiting hyperuricemia and gout effect of evaluation drug in the world.
(2) influence of the alimentation composition to the salt-induced hyperuricemia mice serum uric acid level of Oteracil Potassium
It is Kunming mouse 70, male female fifty-fifty, it is randomly divided into 7 groups, every group 10.That is blank group, hyperuricemia model
Group, positive group, example 1 group, 2 groups of embodiment, 1 group of comparative example, 2 groups of comparative example.Before taking blood 2 hours with oxygen piperazine
Acid potassium salt presses 300mg/kg dosage intraperitoneal injection of mice, and blank group injects isometric 0.5%CMC-Na solution；Administration group is taking blood
It is molten that first 1 hour intraperitoneal injection alimentation composition and other purine group, blank group and model group then inject isometric 0.5%CMC-Na
Liquid.Each group plucks eyeball and takes blood, measures the uric acid content in mice serum, as a result see the table below.
Sample is to mouse because of the influence of the salt-induced hyperuricemia of Oteracil Potassium
Note: * *, p < 0.01, compared with model group is at same time point；▲, p < 0.05 organizes same time ratio with the positive
Compared with；
As it can be seen that embodiment 1,2 groups of embodiment, positive controls, comparative example 1 and 2 groups of comparative example, it can be significant
The serum uric acid of hyperuricemia mouse caused by Oteracil Potassium is reduced, embodiment 1 and 2 groups of embodiment of effect are substantially better than the positive
Control group, hence it is evident that be better than comparative example group, and embodiment effect is close to blank group.
Claims (10)
1. the micro- effervescent tablet of seaweed sodium bicarbonate, which is characterized in that the component including following percentage:
2. the micro- effervescent tablet of seaweed sodium bicarbonate according to claim 1, which is characterized in that the component including following percentage:
3. the micro- effervescent tablet of seaweed sodium bicarbonate according to claim 1 or 2, which is characterized in that the fruit powder is selected from green plum
One or more of powder, grapefruit powder or acerola concentrate powder, papaya powder etc..
4. the micro- effervescent tablet of seaweed sodium bicarbonate according to claim 3, which is characterized in that the plant extracts is medicine food two
Dandelion, sophora flower and Herba Lophatheri extract mixture.
5. the micro- effervescent tablet of seaweed sodium bicarbonate according to claim 4, which is characterized in that dandelion, sophora flower and lophatherum gracile mention
It takes in the mixture of object, the weight ratio of each component are as follows: dandelion extract: Flos Sophorae extract: Herba Lophatheri extract=1:0.5
~1.5:0.5~1.5.
6. the micro- effervescent tablet of seaweed sodium bicarbonate according to claim 5, which is characterized in that the weight ratio of each component are as follows: Pu
Public English extract: Flos Sophorae extract: Herba Lophatheri extract=1:1:1:1.
7. the micro- effervescent tablet of seaweed sodium bicarbonate according to claim 6, which is characterized in that the buffer is hexa metaphosphoric acid
One of sodium, sodium phosphate, sodium dihydrogen phosphate or more than one.
8. the micro- effervescent tablet of seaweed sodium bicarbonate according to claim 1, which is characterized in that the lubricant is selected from micro mist silicon
One of glue, polyethylene glycol, sucrose fatty ester, fumaric acid, alanine, boric acid, sodium benzoate or sodium stearyl fumarate etc.
More than.
9. the preparation method of described in any item micro- effervescent tablets of seaweed sodium bicarbonate according to claim 1~8, which is characterized in that packet
Include following steps:
(1) mixes sodium bicarbonate with solvent, then pelletizes:
(2) the sodium bicarbonate particle of acquisition and unclassified stores (except lubricant) are crossed 20 meshes, mixing by respectively；
(3) it after polyethylene glycol crosses 80 meshes, is mixed with the product of step (2)；
(4) the mixed powder tabletting of step (3) can be obtained the micro- effervescent tablet of seaweed sodium bicarbonate by.
10. according to the method described in claim 9, it is characterized in that, the solvent is the second that volumetric concentration is 75~90%
The maltodextrin solution that alcoholic solution or weight concentration are 3~10%；
The weight ratio of sodium bicarbonate and solvent is 15:1~4:1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910401136.6A CN110101679A (en) | 2019-05-15 | 2019-05-15 | Micro- effervescent tablet of seaweed sodium bicarbonate and its preparation method and application |
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| CN201910401136.6A CN110101679A (en) | 2019-05-15 | 2019-05-15 | Micro- effervescent tablet of seaweed sodium bicarbonate and its preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110772567A (en) * | 2019-08-21 | 2020-02-11 | 杭州娃哈哈科技有限公司 | Cranberry micro-effervescent tablet and preparation method thereof |
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| CN110772567A (en) * | 2019-08-21 | 2020-02-11 | 杭州娃哈哈科技有限公司 | Cranberry micro-effervescent tablet and preparation method thereof |
| CN110772567B (en) * | 2019-08-21 | 2021-09-07 | 杭州娃哈哈科技有限公司 | Cranberry micro-effervescent tablet and preparation method thereof |
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