CN108851079A - A kind of compound preparation of enhancing development and preparation method thereof - Google Patents
A kind of compound preparation of enhancing development and preparation method thereof Download PDFInfo
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- CN108851079A CN108851079A CN201810977969.2A CN201810977969A CN108851079A CN 108851079 A CN108851079 A CN 108851079A CN 201810977969 A CN201810977969 A CN 201810977969A CN 108851079 A CN108851079 A CN 108851079A
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- hawthorn
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- 238000002360 preparation method Methods 0.000 title claims abstract description 41
- 150000001875 compounds Chemical class 0.000 title claims abstract description 26
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 22
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 18
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 18
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 18
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 18
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 18
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 18
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 18
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 18
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 18
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 18
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims abstract description 18
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 claims abstract description 15
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims abstract description 15
- 235000013925 ferrous lactate Nutrition 0.000 claims abstract description 15
- 239000004225 ferrous lactate Substances 0.000 claims abstract description 15
- 229940037907 ferrous lactate Drugs 0.000 claims abstract description 15
- 235000000193 zinc lactate Nutrition 0.000 claims abstract description 15
- 229940050168 zinc lactate Drugs 0.000 claims abstract description 15
- 239000011576 zinc lactate Substances 0.000 claims abstract description 15
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000004472 Lysine Substances 0.000 claims abstract description 14
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 12
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 12
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 12
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 12
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 12
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 12
- 235000019698 starch Nutrition 0.000 claims abstract description 12
- 239000008107 starch Substances 0.000 claims abstract description 12
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 12
- 239000011710 vitamin D Substances 0.000 claims abstract description 12
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 12
- 229940046008 vitamin d Drugs 0.000 claims abstract description 12
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims abstract description 9
- 239000001354 calcium citrate Substances 0.000 claims abstract description 9
- 235000013337 tricalcium citrate Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 20
- 241001092040 Crataegus Species 0.000 claims description 17
- 239000002775 capsule Substances 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 235000020717 hawthorn extract Nutrition 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 235000018977 lysine Nutrition 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 10
- 230000029087 digestion Effects 0.000 abstract description 9
- 238000010521 absorption reaction Methods 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 5
- 210000004185 liver Anatomy 0.000 abstract description 4
- 150000003431 steroids Chemical class 0.000 abstract description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract description 2
- 239000007963 capsule composition Substances 0.000 abstract description 2
- 230000006378 damage Effects 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 210000003734 kidney Anatomy 0.000 abstract description 2
- 210000000214 mouth Anatomy 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 description 25
- 230000012010 growth Effects 0.000 description 9
- 230000001737 promoting effect Effects 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 230000036528 appetite Effects 0.000 description 5
- 235000019789 appetite Nutrition 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 235000005979 Citrus limon Nutrition 0.000 description 4
- 244000131522 Citrus pyriformis Species 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
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- 230000021332 multicellular organism growth Effects 0.000 description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- 230000033116 oxidation-reduction process Effects 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010013883 Dwarfism Diseases 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 108010055297 Sterol Esterase Proteins 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 229960004256 calcium citrate Drugs 0.000 description 1
- 108010089934 carbohydrase Proteins 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000008131 children development Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 231100000001 growth retardation Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to food technology fields, and in particular to a kind of compound preparation of enhancing development and preparation method thereof.Compound preparation of the present invention takes that rear effect is good, without the side effect after Western medicine is taken, without apparent toxicity；By preferred, capsule formulation is convenient to take, does not stimulate digestion, and effect is good, easy to carry；Better than simple steroids Western medicine, to liver kidney without obvious damage, medication is convenient, and patient is easy to receive, and is directly administered from oral cavity, and transmucosal absorption is rapid, rapid-action, patient compliance is good.Compound preparation of the present invention is composed of the following raw materials by weight：500~700 parts of hawthorn, 300~400 parts of malt, 60~120 parts of calcium citrate, 2~6 parts of ferrous lactate, 3~5 parts of zinc lactate, 0.3~0.7 part of vitamin D, 10~15 parts of lysine, 20~50 parts of starch, 50~80 parts of microcrystalline cellulose, are made up of certain preparation method.
Description
One, technical field：
The present invention relates to food technology fields, and in particular to a kind of compound preparation of enhancing development and preparation method thereof.
Two, background technique：
Children are most sensitive to nutrition in crowd, children's early stages（3 years old or less）Nutrition condition it is most important, malnutritive youngster
Child reduces the resistance of disease, it is considered that the child mortality of severe malnutrition is high, World Health Organization's nineteen ninety-five
Data explanation, even slight and moderate malnutrition also results in the death rate and increases, 55% is nutritious in the children of Died Of Disease
It is bad.
Childhood dystrophy not only influences anthropometic, while also influencing the brain growth and intellectual development of children.Early stage seeks
Labour productive forces have direct relation after the situation of supporting and later learning ability, mobility, or even adult；And the Childhood
Height growth deficiency may also lead to certain chronic diseases after adult, as cardiovascular disease, hypertension, the dangerous of diabetes increase.
Therefore the nutrition condition of Childhood should be given to pay special attention to.The growth and development for promoting youngsters and children is one
Item important process.
The method of people's enhancing development at present, doctor trained in Western medicine are mainly to take the drug of some steroids, are unfavorable for growing
Development.The main stomach strengthening and digestion promoting of Chinese medicine is essential therapeutic arsenals.
Take the drug enhancing development of Western medicine steroids, side effect is big, youngsters and children can be caused fat, hormone according to
It relies and the serious side effects such as increased heart rate, anorexia, insomnia, dysfunction of liver.Chinese medicine stomach strengthening and digestion promoting means are taken merely, it is short
It can play the role of increasing appetite in time, but the absorption of the nutritional ingredients such as microelement can be unfavorable for for a long time.
Three, summary of the invention
In view of this, of the invention provides a kind of compound preparation and preparation method thereof of enhancing development.
To achieve the above object, the technical solution adopted by the present invention is：A kind of compound preparation of enhancing development, it is special
Sign is：The compound preparation is composed of the following raw materials by weight：500~700 parts of hawthorn, 300~400 parts of malt, lemon
60~120 parts of sour calcium, 2~6 parts of ferrous lactate, 3~5 parts of zinc lactate, 0.3~0.7 part of vitamin D, 10~15 parts of lysine,
20~50 parts of starch, 50~80 parts of microcrystalline cellulose.
The dosage form of the compound preparation is capsule.
A kind of compound preparation capsule agent preparation method of enhancing development, it is characterised in that：The preparation method is：
1）Hawthorn and malt are cleaned respectively, it is spare；
2）Hawthorn is put into multi-function extractor, is added water to cook 2 times, adds 6~10 times of amount 1~3h of decocting for the first time, for the second time
Add 5~8 times of amount 1~2h of decocting, merge filtrate twice, abandon the dregs of a decoction, be decompressed to 0.070MPa, under the conditions of 60~90 DEG C, is concentrated into
Relative density is 1.05~1.1 mg/ml, and concentrate is spray-dried, obtains haw thorn extract, spare；
3）Malt is put into multi-function extractor, is added water to cook 2 times, adds 6~10 times of amount 1~3h of decocting for the first time, for the second time
Add 3~6 times of amount 1~2h of decocting, merge filtrate twice, abandon the dregs of a decoction, be decompressed to 0.070MPa, under the conditions of 60~90 DEG C, is concentrated into
Relative density is 1.03~1.1 mg/ml, and concentrate is spray-dried, obtains malt extract, spare；
4）Vitamin D is uniformly mixed with ferrous lactate, zinc lactate is added, is uniformly mixed to obtain mixture 1；Mixture 1 and hawthorn
Extract, malt extract, calcium citrate, lysine, starch, microcrystalline cellulose are uniformly mixed, and obtain mixture 2, spare；
5）Mixture 2 is subjected to encapsulated packaging, is examined, storage.
Compared with prior art, the invention has the advantages that and effect：
1, compound preparation of the present invention takes that rear effect is good, without the side effect after Western medicine is taken, without apparent toxicity；It solves
Pure Chinese medicine stomach strengthening and digestion promoting is unfavorable for the absorption problem of the nutritional ingredients such as microelement；
2, preparation process of the present invention is by preferably, capsule formulation is convenient to take, does not stimulate digestion, and effect is good, easy to carry.
3, the present invention is better than simple steroids Western medicine, and to liver kidney without obvious damage, medication is convenient, and patient is easy to receive, from
Oral cavity is directly administered, and transmucosal absorption is rapid, rapid-action, patient compliance is good.
Four, Detailed description of the invention：
Fig. 1 is preparation method flow chart of the present invention.
Five, specific embodiment
It is limited below with reference to specific embodiment technical solution of the present invention is further：
A hawthorn：Promote digestion, whets the appetite；《Compendium of Materia Medica》It records：" product is ground in helping digestion for gulping down ", Chen Hongbin reports it to small
The advancing movement of mouse small intestine has facilitation, and has significant humidification to the activity of pepsin.
B malt：Promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite；It is one of Chinese medicine common medicine.《Records of Tradition Chinese and Western Medicine in Combination》Think that it can " energy
Enter taste, digest the accumulation of all diet, assist product for subsidy taste ".Modern pharmacological research, amylase-containing, conversion carbohydrase,
Vitamin B etc., so peptic effect.
C calcium citrate：Promote bone growth；Hydroxyapatite is formed with phosphorus, bone is constituted, becomes the most fundamental branch of human body
Column.Childhood as taken the photograph hypocalcia for a long time, can cause growth retardation, cartilage structure exception etc..
D ferrous lactate：Participate in oxidation-reduction process, enhancing development；Oxygen is participated in mainly in the form of hemoglobin
Transport and in the form of cytochrome system participate in tissue respiration, push physiological oxidation reduction process.Scarce ferrous lactate can be led
It causes hemoglobin dyspoiesis and scarce ferrous lactate anaemia occurs, keep child development bad.
E zinc lactate：Relationship is developed with body growth and regeneration is in close relations；It is the important of promotion growth in humans's development
One of substance, it is especially particularly evident to the growth and development of children and important.It participates in more than 20 kinds of zinc enzymes of human body and nucleic acid, egg
The synthesis of white matter, it is closely related with body growth development and regeneration.Scarce zinc lactate makes internal various zinc enzymes and containing zinc life
Long hormone sensitive lipase gene is reduced, and height is caused to increases slowly, or even nanism occurs.The shortage of zinc lactate can hinder liver release dimension life
Plain A influences human body to the eubolism and physiological function of vitamin A, and so as to cause dysorexia, growth and development is obstructed, weight
Decline.
F vitamin：Internal microelement is supplemented, absorption of trace elements is promoted；
G lysine：Enhancing development enhances immune function of human body；It is oral easily to absorb, it is one of essential amino acid.Its
Hemoglobin can be increased, anaemia is improved；With enhancing development, enhances human body and exempt from service function.It is that synthesized human growth is wanted
The key factor of element, it is effectively synthesized the calcification speed that can promote sclerotin and deposition, cooperates the lot of trace such as calcium, phosphorus in human body
The absorption of element is improved growth element secretion level.In the children's upgrowth and development phase, increasing is to be unable to do without lysine.
I starch：The consistency of product, the structure of stable prod can be increased；
H microcrystalline cellulose：As adhesive, the structure of stable prod.
In conclusion hawthorn, malt spleen benefiting and stimulating the appetite, promoting digestion and removing indigestion whet the appetite, promote the absorption of nutriment；Simultaneously
Calcium citrate, ferrous lactate, zinc lactate, vitamin D, lysine are supplemented, essential nutrient element can be supplemented, growth can be promoted to send out
It educates.Each ingredient synergistic effect, plays the role of enhancing development in formula.
Embodiment one：
A kind of compound preparation of enhancing development, is composed of the following raw materials by weight：500 parts of hawthorn, 300 parts of malt, lemon
60 parts of sour calcium, 2 parts of ferrous lactate, 3 parts of zinc lactate, 0.3 part of vitamin D, 10 parts of lysine, 20 parts of starch, microcrystalline cellulose 50
Part.
The dosage form of the compound preparation is capsule.
A kind of compound preparation capsule agent preparation method of enhancing development is：
1）Hawthorn and malt are cleaned respectively, it is spare；
2）Hawthorn is put into multi-function extractor, is added water to cook 2 times, adds 6 times of amount 1~3h of decocting for the first time, adds 5 times for the second time
Decocting 1h is measured, filtrate twice is merged, abandons the dregs of a decoction, is decompressed to 0.070MPa, under the conditions of 60 DEG C, being concentrated into relative density is 1.05
Mg/ml, concentrate is spray-dried, obtains haw thorn extract, spare；
3）Malt is put into multi-function extractor, is added water to cook 2 times, adds 6 times of amount 1~3h of decocting for the first time, adds 3 times for the second time
Decocting 1h is measured, filtrate twice is merged, abandons the dregs of a decoction, is decompressed to 0.070MPa, under the conditions of 60 DEG C, being concentrated into relative density is 1.03
Mg/ml, concentrate is spray-dried, obtains malt extract, spare；
4）Vitamin D is uniformly mixed with ferrous lactate, zinc lactate is added, is uniformly mixed to obtain mixture 1；Mixture 1 and hawthorn
Extract, malt extract, calcium citrate, lysine, starch, microcrystalline cellulose are uniformly mixed, and obtain mixture 2, spare；
5）Mixture 2 is subjected to encapsulated packaging, is examined, storage.
Embodiment two：
A kind of compound preparation of enhancing development, is composed of the following raw materials by weight：700 parts of hawthorn, 400 parts of malt, lemon
120 parts of sour calcium, 6 parts of ferrous lactate, 5 parts of zinc lactate, 0.7 part of vitamin D, 15 parts of lysine, 50 parts of starch, microcrystalline cellulose
80 parts.
The dosage form of the compound preparation is capsule.
A kind of compound preparation capsule agent preparation method of enhancing development is：
1）Hawthorn and malt are cleaned respectively, it is spare；
2）Hawthorn is put into multi-function extractor, is added water to cook 2 times, adds 10 times of amount 1~3h of decocting for the first time, adds 8 for the second time
Times amount decocting 2h, merges filtrate twice, abandons the dregs of a decoction, is decompressed to 0.070MPa, and under the conditions of 90 DEG C, being concentrated into relative density is 1.1
Mg/ml, concentrate is spray-dried, obtains haw thorn extract, spare；
3）Malt is put into multi-function extractor, is added water to cook 2 times, adds 10 times of amount decocting 3h, second plus 6 times of amounts for the first time
Decocting 2h merges filtrate twice, abandons the dregs of a decoction, is decompressed to 0.070MPa, and under the conditions of 90 DEG C, being concentrated into relative density is 1.1 mg/
Ml, concentrate is spray-dried, obtains malt extract, spare；
4）Vitamin D is uniformly mixed with ferrous lactate, zinc lactate is added, is uniformly mixed to obtain mixture 1；Mixture 1 and hawthorn
Extract, malt extract, calcium citrate, lysine, starch, microcrystalline cellulose are uniformly mixed, and obtain mixture 2, spare；
5）Mixture 2 is subjected to encapsulated packaging, is examined, storage.
Embodiment three：
A kind of compound preparation of enhancing development, is composed of the following raw materials by weight：600 parts of hawthorn, 350 parts of malt, lemon
100 parts of sour calcium, 5 parts of ferrous lactate, 4 parts of zinc lactate, 0.5 part of vitamin D, 13 parts of lysine, 35 parts of starch, microcrystalline cellulose
70 parts.
The dosage form of the compound preparation is capsule.
A kind of compound preparation capsule agent preparation method of enhancing development is：
1）Hawthorn and malt are cleaned respectively, it is spare；
2）Hawthorn is put into multi-function extractor, is added water to cook 2 times, adds 8 times of amount decocting 2h, second plus 6 times of amounts for the first time
Decocting 1.5h merges filtrate twice, abandons the dregs of a decoction, is decompressed to 0.070MPa, and under the conditions of 80 DEG C, being concentrated into relative density is 1.1
Mg/ml, concentrate is spray-dried, obtains haw thorn extract, spare；
3）Malt is put into multi-function extractor, is added water to cook 2 times, adds 8 times of amount decocting 2h, second plus 5 times of amounts for the first time
Decocting 1.5h merges filtrate twice, abandons the dregs of a decoction, is decompressed to 0.070MPa, and under the conditions of 80 DEG C, being concentrated into relative density is 1.03
Mg/ml, concentrate is spray-dried, obtains malt extract, spare；
4）Vitamin D is uniformly mixed with ferrous lactate, zinc lactate is added, is uniformly mixed to obtain mixture 1；Mixture 1 and hawthorn
Extract, malt extract, calcium citrate, lysine, starch, microcrystalline cellulose are uniformly mixed, and obtain mixture 2, spare；
5）Mixture 2 is subjected to encapsulated packaging, is examined, storage.
Claims (3)
1. a kind of compound preparation of enhancing development, it is characterised in that：The compound preparation is by following raw material group
At：500~700 parts of hawthorn, 300~400 parts of malt, 60~120 parts of calcium citrate, 2~6 parts of ferrous lactate, zinc lactate 3~5
Part, 0.3~0.7 part of vitamin D, 10~15 parts of lysine, 20~50 parts of starch, 50~80 parts of microcrystalline cellulose.
2. a kind of compound preparation of enhancing development according to claim 1, it is characterised in that：The compound preparation
Dosage form be capsule.
3. a kind of compound preparation capsule agent preparation method of enhancing development according to claim 2, it is characterised in that：
The preparation method is：
1）Hawthorn and malt are cleaned respectively, it is spare；
2）Hawthorn is put into multi-function extractor, is added water to cook 2 times, adds 6~10 times of amount 1~3h of decocting for the first time, for the second time
Add 5~8 times of amount 1~2h of decocting, merge filtrate twice, abandon the dregs of a decoction, be decompressed to 0.070MPa, under the conditions of 60~90 DEG C, is concentrated into
Relative density is 1.05~1.1 mg/ml, and concentrate is spray-dried, obtains haw thorn extract, spare；
3）Malt is put into multi-function extractor, is added water to cook 2 times, adds 6~10 times of amount 1~3h of decocting for the first time, for the second time
Add 3~6 times of amount 1~2h of decocting, merge filtrate twice, abandon the dregs of a decoction, be decompressed to 0.070MPa, under the conditions of 60~90 DEG C, is concentrated into
Relative density is 1.03~1.1 mg/ml, and concentrate is spray-dried, obtains malt extract, spare；
4）Vitamin D is uniformly mixed with ferrous lactate, zinc lactate is added, is uniformly mixed to obtain mixture 1；Mixture 1 and hawthorn
Extract, malt extract, calcium citrate, lysine, starch, microcrystalline cellulose are uniformly mixed, and obtain mixture 2, spare；
5）Mixture 2 is subjected to encapsulated packaging, is examined, storage.
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