CN108837045A - A kind of preparation method for paediatric acute tonsillitis, the Chinese medicine composition of acpuei pharyngitis - Google Patents
A kind of preparation method for paediatric acute tonsillitis, the Chinese medicine composition of acpuei pharyngitis Download PDFInfo
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- CN108837045A CN108837045A CN201811128280.9A CN201811128280A CN108837045A CN 108837045 A CN108837045 A CN 108837045A CN 201811128280 A CN201811128280 A CN 201811128280A CN 108837045 A CN108837045 A CN 108837045A
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a kind of preparation method for paediatric acute tonsillitis, the Chinese medicine composition of acpuei pharyngitis, which is that totally ten Six-element bulk pharmaceutical chemicals are processed is prepared by honeysuckle, Fructus Forsythiae, radix scrophulariae, Radix Isatidis, radix paeoniae rubra, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, semen armeniacae amarae, great burdock achene, rhizoma alismatis, the sterculia seed, bombyx batryticatus, cicada slough, Oroxylum indicum；The advantage of the invention is that, compared with prior art, by the improvement to technique, having been surprisingly found that the present invention, curative effect is better, clear efficacy, its clinical pharrnacokinetics test effect significantly improve in terms for the treatment of paediatric acute tonsillitis, acpuei pharyngitis, and safety is without any side effects.
Description
The invention belongs to pharmaceutical technology fields for technical field, and in particular to one kind is used for paediatric acute tonsillitis, acpuei pharyngitis
Chinese medicine composition preparation method.
Background technique
Paediatric acute tonsillitis, acpuei pharyngitis belong to a kind of disease relatively common and multiple in clinic, clinical main table
Now the symptoms such as pain, suppuration, cough, hoarseness are done for throat.Drug therapy is broadly divided into western medical treatment and Chinese traditional treatment at present,
Western medical treatment is mainly based on antibiotic, non-steroidal anti-inflammatory drugs, antihistamine, these drug side effects are relatively common, and body is easy
Generate tolerance, it is very unfavorable to the health of children, Chinese medicine in treatment paediatric acute tonsillitis, in terms of acpuei pharyngitis, mainly with
Based on Chinese patent drug, most of therapeutic effects are unsatisfactory currently on the market, cannot meet clinical needs.
Currently available technology, 1,《The 18th protection kind fascicle two of Traditional Chinese medicine historical preparation》" golden throat is opened under the item of page 182
Sound ball " discloses the prescriptions material of Jinsangkaiyin Pills, without specific dosage, undisclosed preparation process；2,《Chinese Pharmacopoeia 2010
Year version one》Under the item of page 832 " Jinsangkaiyin Pills ", the prescriptions material of Jinsangkaiyin Pills is disclosed, without specific dosage, and it is public
Specific preparation process is opened；3,《Chinese Pharmacopoeia 2015 version one》Under the item of page 1088 " Jinsangkaiyin Pills ", gold is disclosed
Throat opens the prescriptions material of sound ball, without specific dosage, and discloses specific preparation process；4, new drug turns card standard the 75th
Under 33-34 pages of item " Kaiyinwan capsule ", the prescriptions material of Kaiyinwan capsule is disclosed, it is undisclosed to make without specific dosage
Standby technique；The above prior art 1-4 is the open skill of the exclusive kind of my company " Jinsangkaiyin Pills " and " Kaiyinwan capsule "
Art data, 1 and 4 disclose a kind of identical prescription, but without disclosing specific medicinal material dosage, and there is no open specific preparation works
Skill.2 and 3 disclose a kind of identical prescription, but without disclosing specific medicinal material dosage, and disclose specific preparation process, work
Skill is that above ten Six-element is ground into fine powder, refined honey is added, water-honeyed pill or big honeyed bolus is made.5, on 03 20th, 2013 China is special
Sharp bulletin Publication No. " CN102973746A " discloses entitled " a kind of dispelling wind and heat, benefit by the applicant's application
The Chinese medicinal compound extract and its preparation of sound are opened in pharynx " form each herbal medicine raw material in the compound extract of Chinese patent drug of the present invention
Weight proportion be " 13% honeysuckle, 13% Fructus Forsythiae, 13% radix scrophulariae, 11% radix scutellariae, 5% mulberry leaf, 5% chrysanthemum, 5% great burdock achene, 5% cicada slough,
5% radix paeoniae rubra, 5% semen armeniacae amarae, 5% root of purple-flowered peucedanum, 5% sterculia seed, 5% Oroxylum indicum, 5% rhizoma alismatis, compound extract and Radix Isatidis fine powder, bran are fried stiff
The proportion of silkworm fine powder is：12%-98%：0-62%：0-25%, and disclose preparation method：Above 14 kinds of medicinal material co-grindings at
10 times of amounts, 8 times of 70% alcohol refluxs of amount extractions are added in coarse powder, and extracting solution is condensed into medicinal extract, is spray-dried, and compound extraction is made
Object is added 0-62% Radix Isatidis fine powder, 0-25% stir-baked BOMBYX BATRYTICATUS in bran fine powder, cane sugar powder and dextrin and is uniformly mixed, and purifying water spray is added
Granulation, obtains granule at whole grain；Through being tested curative effect and also being paid no attention to applicants have found that the technique of the above prior art 5 is thicker
Think.6.2004 Chinese patent publication Publication No. on November 10, " CN1544069A " disclose by the applicant apply invention
Each herbal medicine that entitled " a kind of Chinese medicine and preparation method thereof for treating acute laryngopharyngitis " forms Chinese patent drug of the present invention is former
The weight proportion of material be " 125 parts of honeysuckle, 125 parts of Fructus Forsythiae, 125 parts of radix scrophulariae, 125 parts of Radix Isatidis, 50 parts of radix paeoniae rubra, 75 parts of radix scutellariae,
50 parts of mulberry leaf, 50 parts of chrysanthemum, 50 parts of the root of purple-flowered peucedanum, 50 parts of semen armeniacae amarae, 50 parts of great burdock achene, 50 parts of rhizoma alismatis, 50 parts of the sterculia seed, bombyx batryticatus 50
Part, 50 parts of cicada slough, 50 parts of Oroxylum indicum "；A kind of prescription for having specific medicinal material dosage and specific preparation method are disclosed, wherein ball
Agent is 16 taste pulverizing medicinal materials, is mixed with refined honey, pill, remaining capsule, tablet and process for producing granula are mainly：Plate is blue
Root, bombyx batryticatus are ground into fine powder；Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, 80% ethyl alcohol heating and refluxing extraction of semen armeniacae amarae；The dregs of a decoction are profound with remaining
Totally ten tastes add water to cook for ginseng, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed, cicada slough, Oroxylum indicum, with 70% ethyl alcohol
Alcohol precipitation, filtering, filtrate merge with alcohol extract, recycle ethyl alcohol and are concentrated, Radix Isatidis, bombyx batryticatus fine powder and sucrose, starch is added, is made
Particle；It is also undesirable through test curative effect through applicants have found that the technique of the above prior art 6 is thicker.The applicant to
For the upper prior art in time back warp development test in recent years, it is thicker to there is technique in discovery, treats during practical application
Imitate undesirable defect.
To overcome defect of the existing technology, applicant is by excavating motherland's natural resources of Chinese medicinal materials abundant, in conjunction with a large amount of
Traditional Chinese medical science prescription theory and Study on clinical pharmacodynamics, make significant improvement to the Product Process using modern pharmaceutical technology, by big
The experiment of amount is groped, and is found surprisingly that original process " dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, pool
Rush down, the sterculia seed, cicada slough, totally ten tastes add water to cook Oroxylum indicum, with 70% ethyl alcohol alcohol precipitation " be changed to " dregs of a decoction and remaining radix scrophulariae, radix scutellariae,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction for mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed, cicada slough, Oroxylum indicum " after,
The preparation made of this technique, clinically the pharmacodynamics test significant effect for paediatric acute tonsillitis, acpuei pharyngitis mentions
Height, and it is without any side effects, active constituent content is high, and preparation stabilization is significant in efficacy.Routinely technique is made for we：?
Granula and lozenge, have better met needs of medical treatment.
Summary of the invention
It is an object of the invention to：There is provided a kind of curative effect it is significantly more it is a kind of for paediatric acute tonsillitis, it is acute
The preparation method of the Chinese medicine composition of pharyngitis, solves in the prior art that de technique is thicker, and preparation stability is bad, and clinic is treated
Imitate the defects of undesirable.
The technical scheme adopted by the invention is that
A kind of preparation method for paediatric acute tonsillitis, the Chinese medicine composition of acpuei pharyngitis, the formula of Chinese medicine composition
It forms and is by weight ratio：
125 parts of honeysuckle, 125 parts of Fructus Forsythiae, 125 parts of radix scrophulariae, 50 parts of radix paeoniae rubra of 125 parts of Radix Isatidis
75 parts of radix scutellariae, 50 parts of mulberry leaf, 50 parts of chrysanthemum, 50 parts of semen armeniacae amarae of 50 portions of the root of purple-flowered peucedanum
50 parts of great burdock achene, 50 parts of rhizoma alismatis, 50 parts of the sterculia seed, 50 parts of cicada slough of 50 portions of bombyx batryticatus
50 parts of Oroxylum indicum
Preparation method is：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into coarse powder, 40-60 mesh is crossed, is heated to reflux with 80% ethyl alcohol
Extract secondary, 2 hours every time, combined extract, filtration, filtrate was spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream, add step 2 preparation Radix Isatidis, bombyx batryticatus fine powder and appropriate auxiliary material, by the common process of each preparation be made granule,
Lozenge.
1. the preparation method of granule is：
The formula composition of Chinese medicine composition is by weight ratio：
125 parts of honeysuckle, 125 parts of Fructus Forsythiae, 125 parts of radix scrophulariae, 50 parts of radix paeoniae rubra of 125 parts of Radix Isatidis
75 parts of radix scutellariae, 50 parts of mulberry leaf, 50 parts of chrysanthemum, 50 parts of semen armeniacae amarae of 50 portions of the root of purple-flowered peucedanum
50 parts of great burdock achene, 50 parts of rhizoma alismatis, 50 parts of the sterculia seed, 50 parts of cicada slough of 50 portions of bombyx batryticatus
50 parts of Oroxylum indicum
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into coarse powder, 40-60 mesh is crossed, is heated to reflux with 80% ethyl alcohol
Extract secondary, 2 hours every time, combined extract, filtration, filtrate was spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream, add the Radix Isatidis of step 2 preparation, bombyx batryticatus fine powder and and Icing Sugar, dextrin, spraying granulation is dry, be made particle to get
Granule.
2. the preparation method of lozenge is：
The formula composition of Chinese medicine composition is by weight ratio：
125 parts of honeysuckle, 125 parts of Fructus Forsythiae, 125 parts of radix scrophulariae, 50 parts of radix paeoniae rubra of 125 parts of Radix Isatidis
75 parts of radix scutellariae, 50 parts of mulberry leaf, 50 parts of chrysanthemum, 50 parts of semen armeniacae amarae of 50 portions of the root of purple-flowered peucedanum
50 parts of great burdock achene, 50 parts of rhizoma alismatis, 50 parts of the sterculia seed, 50 parts of cicada slough of 50 portions of bombyx batryticatus
50 parts of Oroxylum indicum
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into coarse powder, 40-60 mesh is crossed, is heated to reflux with 80% ethyl alcohol
Extract secondary, 2 hours every time, combined extract, filtration, filtrate was spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream adds Radix Isatidis, bombyx batryticatus fine powder and the proper auxiliary materials of step 2 preparation, pelletizes, and dry, whole grain, tabletting is to get lozenge.
The beneficial effects of the invention are as follows：The Chinese medicine provided by the present invention for being used for paediatric acute tonsillitis, acpuei pharyngitis
The preparation method of composition significantly increases the clinical pharrnacokinetics test effect of said medicine, and without any side effects, work
Skill is advanced, and active constituent content is high, and better stability of preparation is significant in efficacy.
Pharmacodynamic test of active extract is as follows：
One, the preparation of experimental drug：
1. raw material：
Of the present invention group：Granule made from method according to description of the invention embodiment 1, it is specific as follows：
The formula composition of Chinese medicine composition（By weight ratio）For：
Honeysuckle 163g Fructus Forsythiae 163g radix scrophulariae 163g Radix Isatidis 163g radix paeoniae rubra 65g
Radix scutellariae 98g mulberry leaf 65g chrysanthemum 65g root of purple-flowered peucedanum 65g semen armeniacae amarae 65g
Great burdock achene 65g rhizoma alismatis 65g sterculia seed 65g bombyx batryticatus 65g cicada slough 65g
Oroxylum indicum 65g；
The preparation method of granule is as follows：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into 40-60 mesh coarse powder, with 80% ethyl alcohol heating and refluxing extraction two
Secondary, 2 hours every time, combined extract filtered, and filtrate is spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream adds Radix Isatidis, bombyx batryticatus fine powder and the Icing Sugar, dextrin of step 3 preparation, and spraying granulation is dry, be made particle to get
Granula.
Group：Due to the dosage of prior art 1-3 undisclosed " Jinsangkaiyin Pills " specific bulk pharmaceutical chemicals, but disclose preparation side
Method, now according to the prescription dosage in " CN1544069A " specification of the prior art 6 embodiment 5, in conjunction with the disclosure of the prior art 2 and 3
" Jinsangkaiyin Pills " preparation method, pill obtained；
The formula composition of Chinese medicine composition（By weight ratio）For：
Honeysuckle 245g Fructus Forsythiae 245g radix scrophulariae 245g Radix Isatidis 245g radix paeoniae rubra 98g
Radix scutellariae 147g mulberry leaf 98g chrysanthemum 98g root of purple-flowered peucedanum 98g semen armeniacae amarae 98g
Great burdock achene 98g rhizoma alismatis 98g sterculia seed 98g bombyx batryticatus 98g cicada slough 98g
Oroxylum indicum 98g；
The preparation method of pill is：Above ten Six-element, is ground into fine powder, is sieved, and mixes, and every 100g powder adds refined honey 35-50g
With suitable water, pill is dry, is coated with active carbon, water-honeyed pill is made；Or add refined honey 110-130g be made big honeyed bolus to get.
Group：According to the claim 1 of the patent application claims book of 5 Publication No. CN102973746A of the prior art,
6, granule made from preparation method provided by 7, compares for convenience, we are said using the prior art 6 " CN1544069A "
Prescription dosage in bright book embodiment 5；
The formula composition of Chinese medicine composition（By weight ratio）For：
Honeysuckle 245g Fructus Forsythiae 245g radix scrophulariae 245g Radix Isatidis 245g radix paeoniae rubra 98g
Radix scutellariae 147g mulberry leaf 98g chrysanthemum 98g root of purple-flowered peucedanum 98g semen armeniacae amarae 98g
Great burdock achene 98g rhizoma alismatis 98g sterculia seed 98g bombyx batryticatus 98g cicada slough 98g
Oroxylum indicum 98g；
Preparation method：
Step 1：It is extracting honeysuckle, Fructus Forsythiae, radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, great burdock achene, cicada slough, radix paeoniae rubra, semen armeniacae amarae, the root of purple-flowered peucedanum, fat
Sea, Oroxylum indicum and rhizoma alismatis co-grinding are at coarse powder；
Step 2：10 times of amounts, 8 times of 70% alcohol refluxs of amount are added to extract respectively 2 times mixing coarse powder obtained by step 1,2 is small every time
When, combined extract filters, and filtrate is concentrated into the medicinal extract that relative density is 1.10-1.15 when temperature is 60 DEG C；
Step 3：By the spray drying of medicinal extract obtained by step 2, compound extract is made；
Step 4：Radix Isatidis and bombyx batryticatus are respectively crushed into fine powder；
Step 5：By Radix Isatidis fine powder obtained by three gained compound extract of above step and step 4 and bombyx batryticatus fine powder and appropriate sugarcane
Icing Sugar, dextrin are uniformly mixed, and using purified water as adhesive spraying granulation, whole grain is to get granule.
Group：According to granule made from the method in " CN1544069A " specification of the prior art 6 embodiment 5.
The formula composition of Chinese medicine composition（By weight ratio）For：
Honeysuckle 245g Fructus Forsythiae 245g radix scrophulariae 245g Radix Isatidis 245g radix paeoniae rubra 98g
Radix scutellariae 147g mulberry leaf 98g chrysanthemum 98g root of purple-flowered peucedanum 98g semen armeniacae amarae 98g
Great burdock achene 98g rhizoma alismatis 98g sterculia seed 98g bombyx batryticatus 98g cicada slough 98g
Oroxylum indicum 98g；
The preparation method of granule is as follows：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, after mixing, spare；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into 40-60 mesh coarse powder, with 80% ethyl alcohol heating and refluxing extraction two
Secondary, 2 hours every time, filtrate was collected in combined extract, filtration；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Cicada slough, Oroxylum indicum totally ten tastes add water to cook it is secondary, 2 hours every time, collecting decoction, filtration, filtrate be concentrated into temperature be 50 DEG C
When, relative density be 1.18-1.20 clear cream, add ethyl alcohol to make alcohol content up to 70%, stir evenly, stand, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and being concentrated into when temperature is 60 DEG C, measure relative density is 1.38-
1.40 clear cream adds the fine powder of step 2 preparation；
Step 5：Then 400g sucrose, 200g starch are added, is pelletized to get granule.
Group：For present invention process different ethanol concentration（40% ethyl alcohol）Screening group, it is specific as follows：
The formula composition of Chinese medicine composition（By weight ratio）For：
Honeysuckle 163g Fructus Forsythiae 163g radix scrophulariae 163g Radix Isatidis 163g radix paeoniae rubra 65g
Radix scutellariae 98g mulberry leaf 65g chrysanthemum 65g root of purple-flowered peucedanum 65g semen armeniacae amarae 65g
Great burdock achene 65g rhizoma alismatis 65g sterculia seed 65g bombyx batryticatus 65g cicada slough 65g
Oroxylum indicum 65g；
The preparation method of granule is as follows：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into 40-60 mesh coarse powder, with 80% ethyl alcohol heating and refluxing extraction two
Secondary, 2 hours every time, combined extract filtered, and filtrate is spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 40% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream adds Radix Isatidis, bombyx batryticatus fine powder and the Icing Sugar, dextrin of step 2 preparation, and spraying granulation is dry, be made particle to get
Granula.
Group：For present invention process different ethanol concentration（80% ethyl alcohol）Screening group, it is specific as follows：
The formula composition of Chinese medicine composition（By weight ratio）For：
Honeysuckle 163g Fructus Forsythiae 163g radix scrophulariae 163g Radix Isatidis 163g radix paeoniae rubra 65g
Radix scutellariae 98g mulberry leaf 65g chrysanthemum 65g root of purple-flowered peucedanum 65g semen armeniacae amarae 65g
Great burdock achene 65g rhizoma alismatis 65g sterculia seed 65g bombyx batryticatus 65g cicada slough 65g
Oroxylum indicum 65g；
Process for producing granula is as follows：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into 40-60 mesh coarse powder, with 80% ethyl alcohol heating and refluxing extraction two
Secondary, 2 hours every time, combined extract filtered, and filtrate is spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 80% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream adds Radix Isatidis, bombyx batryticatus fine powder and the Icing Sugar, dextrin of step 2 preparation, and spraying granulation is dry, be made particle to get
Granula.
Two, process and test result are tested：
Experiment purpose：The pharmacological evaluation of the effects of by the anti-inflammatory of of the present invention group and a.b.c.d.e group, analgesia, antipyretic, eliminating the phlegm
Present invention group and a.b.c.d.e group are compared, observe the power of its pharmacological action by research.
Test method：Of the present invention group and a.b.c.d.e group paraxylene causes the influence of mouse ear swelling；To mouse blood capillary
The influence of pipe permeability；The influence of Dichlorodiphenyl Acetate induced mice writhing number；Cause the influence of fever in rabbits to triple vaccine；To small
The influence of the phenol red secretory volume of mouse.
One, paraxylene causes the influence of mouse ear swelling
Experimental material
1, animal：Kunming mouse, male and female have concurrently, 18~22g of weight.
2, drug：Of the present invention group and a, b, c, d, e group；Drug is configured before experiment with distilled water, gastric infusion.
Experimental method
Kunming mouse 70, half male and half female, 18~22g of weight is randomly divided into 7 groups, every group 10.Control group stomach-filling same volume
Physiological saline；Of the present invention group and a, b, c, d, e group difference gastric infusion 3.6g/kg；Successive administration 7d, one time a day, last is given
Dimethylbenzene 0.05mL is uniformly applied to mouse right ear after medicine 1h, left ear, which does not apply, to be compareed, and left and right auricle is cut after 30min, with straight
8 millimeters of punch of diameter remove two auricles simultaneously, and electronic balance weighing calculates ear swelling rate.Experimental result：It is shown in Table 1
Ear swelling rate (%)=[ (auris dextra quality-left ear quality)/left ear quality ] × 100%
The influence of 1 paraxylene of table cause mouse ear swelling（±s）
* * P < 0.01 compared with the control group；With of the present invention group than △ P < 0.05.
The result shows that：Of the present invention group and a, b, c, d, e group are substantially reduced mouse ear swelling rate, there is pole compared with the control group
Significant difference（P< 0.01）；A, b, c, d, e group have significant difference compared with of the present invention group（P< 0.05）；The effect of e group
Better than a, b, c, d group, but there was no significant difference.As it can be seen that the of the present invention group of effect more anti-inflammatory than a, b, c, d, e group is strong.
Two, to the influence of mouse capillary permeability
Experimental material
1, animal：Kunming mouse, male and female have concurrently, 18~22g of weight.
2, drug：Of the present invention group and a, b, c, d, e group；Drug is configured before experiment with distilled water, gastric infusion.
Experimental method
Kunming mouse 70, half male and half female, 18~22g of weight is randomly divided into 7 groups, every group 10.Control group stomach-filling same volume
Physiological saline；Of the present invention group and a, b, c, d, e group difference gastric infusion 3.6g/kg；Successive administration 7d, one time a day, last is given
After medicine 1h, 0.5% evans blue normal saline solution (0.01g/kg) of each group mouse tail vein injection is injected intraperitoneally 0.6% immediately
Glacial acetic acid, 0.2mL/ only, put to death after 20min by cervical dislocation, and abdominal cut integumentary musculature washs abdomen with 6mL physiological saline in several times
Chamber, is sucked out cleaning solution with suction pipe, and physiological saline is added after merging to 10mL, and 3000r/min is centrifuged 15min, take supernatant in point
OD value is measured at light photometer 590nm.Experimental result：It is shown in Table 2
Influence of the table 2 to mouse capillary permeability（±s）
* * P < 0.01 compared with the control group；With of the present invention group than △ P < 0.05.
The result shows that：Of the present invention group and a, b, c, d, e group are substantially reduced OD value, hence it is evident that inhibit glacial acetic acid induced mice abdomen
Portion's capillary permeability is hyperfunction, there is extremely significant sex differernce compared with the control group（P < 0.01）；A, b, c, d, e group and the present invention
Group, which compares, significant difference（P < 0.05）；The effect of e group is better than a, b, c, d group, but there was no significant difference.As it can be seen that of the invention
The anti-inflammatory effect of group ratio a, b, c, d, e group is strong.
Three, the influence of Dichlorodiphenyl Acetate induced mice writhing number
Experimental material
1, animal：Kunming mouse, male and female have concurrently, 18~22g of weight.
2, drug：Of the present invention group and a, b, c, d, e group；Drug is configured before experiment with distilled water, gastric infusion.
Experimental method
Kunming mouse 70, half male and half female, 18~22g of weight is randomly divided into 7 groups, every group 10.Control group stomach-filling same volume
Physiological saline；Of the present invention group and a, b, c, d, e group difference gastric infusion 3.6g/kg；Successive administration 7d, one time a day, in last
After 0.6% acetum 0.01mL/g, 5min is injected intraperitoneally after administration 1h, each group mouse writhing number in 15min is observed.Experiment
As a result：It is shown in Table 3
The influence of 3 Dichlorodiphenyl Acetate induced mice writhing number of table（±s）
| Grouping | Animal（Only） | Dosage（g/kg） | Writhing number |
| Control group | 10 | — | 38±9 |
| A group | 10 | 3.6 | 28±6**△ |
| B group | 10 | 3.6 | 27±6**△ |
| C group | 10 | 3.6 | 27±7**△ |
| D group | 10 | 3.6 | 28±5**△ |
| E group | 10 | 3.6 | 25±3**△ |
| Of the present invention group | 10 | 3.6 | 18±10** |
* * P < 0.01 compared with the control group；With of the present invention group than △ P < 0.05.
The result shows that：Of the present invention group and a, b, c, d, e group significantly reduce the writhing number of mouse, have compared with the control group
Extremely significant sex differernce（P < 0.01）；A, b, c, d, e group have significant difference compared with of the present invention group（P < 0.05）；E group is made
With a, b, c, d group is better than, but there was no significant difference.As it can be seen that of the present invention group stronger than the effect of a, b, c, d, e group analgesic.
Four, cause the influence of fever in rabbits to triple vaccine
Experimental material
1, animal：Kunming mouse, male and female have concurrently, 18~22g of weight.
2, drug：Of the present invention group and a, b, c, d, e group；Drug is configured before experiment with distilled water, gastric infusion.
Experimental method
Kunming mouse 70, half male and half female, 18~22g of weight is randomly divided into 7 groups, every group 10.Control group stomach-filling same volume
Distilled water；Of the present invention group and a, b, c, d, e group difference gastric infusion 0.9g/kg；Successive administration 3d, one time a day, dosage
20ml/kg, 1h is injected intravenously Vaccinum Pertussis et Toxoidum Diphthero Tetanicum Adsorbatum, diphtheria, tetanus toxin mix preparation after last medicine, after recording pyrogenicity
1.5,3.0, the variation of 6.0h anus temperature.Experimental result：It is shown in Table 4
Table 4 causes the influence of fever in rabbits to triple vaccine（±s）
* * P < 0.01 compared with the control group；With of the present invention group than △ P < 0.05.
The result shows that：Of the present invention group and a, b, c, d, e group have apparent inhibiting effect to rabbit body temperature raising, cause to rabbit
Raised anus temperature is substantially reduced after 1.5h, 3h, 6h after inflammation, there is extremely significant sex differernce compared with the control group（P < 0.01）；a,b,c,
D, e group has significant difference compared with of the present invention group（P < 0.05）；The effect of e group is better than a, b, c, d group, but poor without conspicuousness
It is different.As it can be seen that the of the present invention group of effect more antipyretic than a, b, c, d, e group is strong.
Five, to the influence of the phenol red secretory volume of mouse
Experimental material
1, animal：Kunming mouse, male and female have concurrently, 18~22g of weight.
2, drug：Of the present invention group and a, b, c, d, e group；Drug is configured before experiment with distilled water, gastric infusion.
Experimental method
Kunming mouse 70, half male and half female, 18~22g of weight is randomly divided into 7 groups, every group 10.Control group stomach-filling same volume
Physiological saline；Of the present invention group and a, b, c, d, e group difference gastric infusion 3.6g/kg；Successive administration 7d, one time a day.Last is given
After medicine 0.5h, after 10% phenol red solution 0.2ml/10g, 0.5h is injected intraperitoneally in each group, mouse is put to death, position is faced upward and fixes, separate gas
Pipe；5%NaHCO is extracted with syringe3Liquid 0.4ml, transtracheal are injected intrapulmonary, are washed 3 times, and liquid injection small test tube will be washed.So
It is repeated 3 times, washes liquid for 3 times and merge, centrifugation is spare.It takes the red after being centrifuged is clear and bright to wash liquid 0.5ml, is added 1.5ml5%'s
NaHCO3Liquid mixes, and absorbance value is measured at ultraviolet-uisible spectrophotometer 546nm wavelength, calculates from phenol red standard curve each
The respective concentration of absorbance value.Experimental result：It is shown in Table 5
Influence of the table 5 to the phenol red secretory volume of mouse（±s）
| Grouping | Animal（Only） | Dosage（g/kg） | Phenol red secretory volume (μ g/ml) |
| Control group | 10 | — | 1.725±0.329 |
| A group | 10 | 3.6 | 2.046±0.118**△ |
| B group | 10 | 3.6 | 2.048±0.125**△ |
| C group | 10 | 3.6 | 2.043±0.113**△ |
| D group | 10 | 3.6 | 2.051±0.128**△ |
| E group | 10 | 3.6 | 2.124±0.108**△ |
| Of the present invention group | 10 | 3.6 | 2.457±0.476** |
* * P < 0.01 compared with the control group；With of the present invention group than △ P < 0.05.
The result shows that：Of the present invention group and a, b, c, d, e group are obviously promoted the phenol red secretory volume of mouse, compared with the control group
There is extremely significant sex differernce（P < 0.01）；A, b, c, d, e group have significant difference compared with of the present invention group（P < 0.05）；E group
Effect is better than a, b, c, d group, but there was no significant difference.As it can be seen that the of the present invention group of effect than a, b, c, d, e group eliminating the phlegm is strong.
Experimental result：Of the present invention group and a.b.c.d.e group are substantially reduced mouse ear swelling rate；It is substantially reduced OD value, hence it is evident that inhibit
Glacial acetic acid induced mice abdomen capillary permeability is hyperfunction；Significantly reduce the writhing number of mouse；Rabbit body temperature raising has bright
Aobvious inhibiting effect；It is obviously promoted the phenol red secretory volume of mouse.
Conclusion：It is of the present invention group stronger than pharmacological actions such as the anti-inflammatory of a.b.c.d.e group, analgesia, antipyretic, eliminating the phlegm.Therefore, clinical
It is upper of the present invention group stronger than a.b.c.d.e group treatment paediatric acute tonsillitis, the effect of acpuei pharyngitis.
The specific embodiment of the invention：
The present invention is further explained in the light of specific embodiments, but not as limitation of the present invention.
Embodiment 1：
The traditional chinese medicine composition of the invention is made of the bulk pharmaceutical chemicals of following weight proportion：
Honeysuckle 163g Fructus Forsythiae 163g radix scrophulariae 163g Radix Isatidis 163g radix paeoniae rubra 65g
Radix scutellariae 98g mulberry leaf 65g chrysanthemum 65g root of purple-flowered peucedanum 65g semen armeniacae amarae 65g
Great burdock achene 65g rhizoma alismatis 65g sterculia seed 65g bombyx batryticatus 65g cicada slough 65g
Oroxylum indicum 65g；
The preparation method of granule is as follows：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into 40-60 mesh coarse powder, with 80% ethyl alcohol heating and refluxing extraction two
Secondary, 2 hours every time, combined extract filtered, and filtrate is spare；
Step 4；By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 60 DEG C is the clear of 1.38-1.40
Cream adds Radix Isatidis, bombyx batryticatus fine powder and the Icing Sugar, dextrin of step 2 preparation, and spraying granulation is dry, be made particle to get
Granula.
Embodiment 2：
The traditional chinese medicine composition of the invention is made of the bulk pharmaceutical chemicals of following weight proportion：
Honeysuckle 163g Fructus Forsythiae 163g radix scrophulariae 163g Radix Isatidis 163g radix paeoniae rubra 65g
Radix scutellariae 98g mulberry leaf 65g chrysanthemum 65g root of purple-flowered peucedanum 65g semen armeniacae amarae 65g
Great burdock achene 65g rhizoma alismatis 65g sterculia seed 65g bombyx batryticatus 65g cicada slough 65g
Oroxylum indicum 65g；
The preparation method of lozenge is as follows：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into 40-60 mesh coarse powder, with 80% ethyl alcohol heating and refluxing extraction two
Secondary, 2 hours every time, combined extract filtered, and filtrate is spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream adds Radix Isatidis, bombyx batryticatus fine powder and the proper auxiliary materials of step 2 preparation, pelletizes, and dry, whole grain, tabletting is to get lozenge.
Claims (3)
1. a kind of preparation method for paediatric acute tonsillitis, the Chinese medicine composition of acpuei pharyngitis, which is characterized in that
The formula composition of Chinese medicine composition is by weight ratio：
125 parts of honeysuckle, 125 parts of Fructus Forsythiae, 125 parts of radix scrophulariae, 50 parts of radix paeoniae rubra of 125 parts of Radix Isatidis
75 parts of radix scutellariae, 50 parts of mulberry leaf, 50 parts of chrysanthemum, 50 parts of semen armeniacae amarae of 50 portions of the root of purple-flowered peucedanum
50 parts of great burdock achene, 50 parts of rhizoma alismatis, 50 parts of the sterculia seed, 50 parts of cicada slough of 50 portions of bombyx batryticatus
50 parts of Oroxylum indicum
Preparation method is：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into coarse powder, 40-60 mesh is crossed, is heated to reflux with 80% ethyl alcohol
Extract secondary, 2 hours every time, combined extract, filtration, filtrate was spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream, add step 2 preparation Radix Isatidis, bombyx batryticatus fine powder and appropriate auxiliary material, by the common process of each preparation be made granule,
Lozenge.
2. a kind of preparation for paediatric acute tonsillitis, the Chinese medicine composition of acpuei pharyngitis according to claim 1
Method, which is characterized in that
The formula composition of Chinese medicine composition is by weight ratio：
125 parts of honeysuckle, 125 parts of Fructus Forsythiae, 125 parts of radix scrophulariae, 50 parts of radix paeoniae rubra of 125 parts of Radix Isatidis
75 parts of radix scutellariae, 50 parts of mulberry leaf, 50 parts of chrysanthemum, 50 parts of semen armeniacae amarae of 50 portions of the root of purple-flowered peucedanum
50 parts of great burdock achene, 50 parts of rhizoma alismatis, 50 parts of the sterculia seed, 50 parts of cicada slough of 50 portions of bombyx batryticatus
50 parts of Oroxylum indicum
The preparation method of granule is：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into coarse powder, 40-60 mesh is crossed, is heated to reflux with 80% ethyl alcohol
Extract secondary, 2 hours every time, combined extract, filtration, filtrate was spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream, add the Radix Isatidis of step 2 preparation, bombyx batryticatus fine powder and and Icing Sugar, dextrin, spraying granulation is dry, be made particle to get
Granule.
3. a kind of preparation for paediatric acute tonsillitis, the Chinese medicine composition of acpuei pharyngitis according to claim 1
Method, which is characterized in that
The formula composition of Chinese medicine composition is by weight ratio：
125 parts of honeysuckle, 125 parts of Fructus Forsythiae, 125 parts of radix scrophulariae, 50 parts of radix paeoniae rubra of 125 parts of Radix Isatidis
75 parts of radix scutellariae, 50 parts of mulberry leaf, 50 parts of chrysanthemum, 50 parts of semen armeniacae amarae of 50 portions of the root of purple-flowered peucedanum
50 parts of great burdock achene, 50 parts of rhizoma alismatis, 50 parts of the sterculia seed, 50 parts of cicada slough of 50 portions of bombyx batryticatus
50 parts of Oroxylum indicum
The preparation method of lozenge is：
Step 1：Bombyx batryticatus bran is fried, it is spare after semen armeniacae amarae peeling；
Step 2：Radix Isatidis, bombyx batryticatus are ground into fine powder, cross 100-120 mesh, it is spare after mixing；
Step 3：Honeysuckle, Fructus Forsythiae, radix paeoniae rubra, semen armeniacae amarae are ground into coarse powder, 40-60 mesh is crossed, is heated to reflux with 80% ethyl alcohol
Extract secondary, 2 hours every time, combined extract, filtration, filtrate was spare；
Step 4：By in step 3 the dregs of a decoction and remaining radix scrophulariae, radix scutellariae, mulberry leaf, chrysanthemum, the root of purple-flowered peucedanum, great burdock achene, rhizoma alismatis, the sterculia seed,
Totally ten tastes add 60% ethyl alcohol heating and refluxing extraction secondary for cicada slough, Oroxylum indicum, 2 hours every time, combined extract, filtration, filtrate with it is upper
The ethanol extract stated in step 3 merges, and recycling ethyl alcohol and measuring relative density when being concentrated into 50 DEG C is the clear of 1.05-1.10
Cream adds Radix Isatidis, bombyx batryticatus fine powder and the proper auxiliary materials of step 2 preparation, pelletizes, and dry, whole grain, tabletting is to get lozenge.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114668805A (en) * | 2020-12-25 | 2022-06-28 | 西安碑林药业股份有限公司 | Use of composition in preparing medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453016A (en) * | 2003-05-21 | 2003-11-05 | 西安碑林药业股份有限公司 | Chinese medicine for treating acute laryngopharyngitis and its prepn |
| CN1544069A (en) * | 2003-05-21 | 2004-11-10 | 西安碑林药业股份有限公司 | Chinese traditional medicine for treating acute laryngopharyngitis and its preparing process |
| US20060257507A1 (en) * | 2002-06-06 | 2006-11-16 | J.B. Chemicals & Pharmaceuticals, Ltd. | Herbal cough formulations and process for the preparation thereof |
| CN102973746A (en) * | 2012-12-18 | 2013-03-20 | 西安碑林药业股份有限公司 | Compound Chinese herbal extract for dispelling wind, clearing heat and relieving sore-throat to restore voice, and preparations thereof |
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2018
- 2018-09-27 CN CN201811128280.9A patent/CN108837045A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060257507A1 (en) * | 2002-06-06 | 2006-11-16 | J.B. Chemicals & Pharmaceuticals, Ltd. | Herbal cough formulations and process for the preparation thereof |
| CN1453016A (en) * | 2003-05-21 | 2003-11-05 | 西安碑林药业股份有限公司 | Chinese medicine for treating acute laryngopharyngitis and its prepn |
| CN1544069A (en) * | 2003-05-21 | 2004-11-10 | 西安碑林药业股份有限公司 | Chinese traditional medicine for treating acute laryngopharyngitis and its preparing process |
| CN102973746A (en) * | 2012-12-18 | 2013-03-20 | 西安碑林药业股份有限公司 | Compound Chinese herbal extract for dispelling wind, clearing heat and relieving sore-throat to restore voice, and preparations thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114668805A (en) * | 2020-12-25 | 2022-06-28 | 西安碑林药业股份有限公司 | Use of composition in preparing medicine |
| CN114668805B (en) * | 2020-12-25 | 2023-08-08 | 西安碑林药业股份有限公司 | Use of a composition in the preparation of a medicament |
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Application publication date: 20181120 |