CN108836961A - A kind of Chinese medicine composition for treating stomachache - Google Patents
A kind of Chinese medicine composition for treating stomachache Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, especially a kind of Chinese medicine composition for treating stomachache, using Fructus cinnamomi camphorae, longpeduncle kadsura stem, paniculate swallowwort, evodia rutaecarpa, tinosporae, adder-wort is total to the extract of Six-element Chinese medicinal material, 1 preferably in Fructus cinnamomi camphorae, 8- Cineole, five lactone E in longpeduncle kadsura stem, paeonol in paniculate swallowwort, evodene in evodia rutaecarpa, tinosporine in tinosporae, gallic acid in adder-wort, after mentioned component is matched, for treating stomachache disease with significant in efficacy, it is rapid-action, period short feature, in particular for gastritis, there is significant curative effect in terms of duodenal ulcer disease.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, especially a kind of Chinese medicine composition for treating stomachache.
Background technique
Stomachache, also known as epigastric pain, peratodynia, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, are using pain at the nearly discrimination bone in gastral cavilty portion as the one of cardinal symptom
Kind illness, the acute and chronic gastritis being equivalent in western medicine, taste-blindness rate disease, gastric neurosis, gastroptosis, stomach convulsion
The diseases such as contraction；Stomachache is clinically most commonly seen one of multiple illness, and stomachache is mainly the closest with liver, spleen relationship, early
?《The Yellow Emperor's Canon of Internal Medicine》In just have the characteristics of recorded, stomachache has the course of disease long, easy recurrent exerbation.
Nowadays, with the acceleration of people's life rhythm and the change of dietary structure, the disease incidence of stomachache also increase year by year
Trend, and fall ill increasingly rejuvenation, seriously affected work, study and daily life, however adopted in the prior art
The feature for having treatment cycle short, rapid-action with western medical treatment, but it is easy to produce drug resistance, tolerance, or even can also cause one
A little side effects；And Chinese medicine is used to treat, by the way that function of human body is mediated, to reach equilibrium between yin and yang, so that illness obtains
To healing, but since its curative effect is not rapid enough, the effective component mechanism of action is indefinite, and dosage is big, and treatment cycle is long, leads
Cause can not be promoted widely, as patent CN100488534C is disclosed using Fructus cinnamomi camphorae, longpeduncle kadsura stem, paniculate swallowwort, Wu
The fruit of medicinal cornel, tinosporae, adder-wort are that raw material is prepared into Chinese materia medica preparation, and effective component type and content is more multiple in disclosed raw material
Miscellaneous, the mechanism of action of various composition is also and indefinite, and therefore, the present invention is carried out for the effective component monomer in above-mentioned medicinal material
Research is dedicated to developing a kind of novel pharmaceutical preparation.
Summary of the invention
In order to solve the above technical problems, the present invention provides, one kind is rapid-action, and the period is short, in safe and reliable treatment stomachache
Drug composition.
It is achieved particular by following technical scheme：
A kind of Chinese medicine composition for treating stomachache, raw material are 3~5 parts of Fructus cinnamomi camphorae monomer, spiced blood in parts by weight
6~10 parts of rattan monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~1.6, fist
0.9~4.5 part of monomer of ginseng.
The raw material be in parts by weight 4 parts of Fructus cinnamomi camphorae list, 8 parts of longpeduncle kadsura stem monomer, 2.5 parts of paniculate swallowwort monomer,
1.8 parts of evodia rutaecarpa monomer, tinosporae monomer 1.2,2.5 parts of adder-wort monomer.
The Fructus cinnamomi camphorae monomer is 1, 8-Cineole, and longpeduncle kadsura stem monomer is five lactone E, and paniculate swallowwort monomer is tree peony
Phenol, evodia rutaecarpa monomer are evodene, and tinosporae monomer is tinosporine, adder-wort monomer is gallic acid,
Contain schizandrin A in the longpeduncle kadsura stem.
The weight ratio of five lactone E and schizandrin A is 1 in the longpeduncle kadsura stem monomer：(0.015~0.02).
The composition is any preparation for being clinically suitable for.
Purposes of the Chinese medicine composition in treatment stomachache drug.
Beneficial effect
The traditional chinese medicine composition of the invention is by using Fructus cinnamomi camphorae, longpeduncle kadsura stem, paniculate swallowwort, evodia rutaecarpa, tinosporae, adder-wort
It is total to the extract of Six-element Chinese medicinal material, the preferably 1, 8-Cineole in Fructus cinnamomi camphorae, five lactone E in longpeduncle kadsura stem, Xu
Paeonol in long minister in ancient times, the evodene in evodia rutaecarpa, the tinosporine in tinosporae, the gallic acid in adder-wort pass through
After mentioned component is matched, have the characteristics that significant in efficacy, rapid-action, the period is short for treating stomachache disease, especially
There is significant curative effect in terms of for gastritis, duodenal ulcer disease.
Specific embodiment
Tuberculosis specific embodiment is limited technical solution of the present invention is further below, but claimed
Range is not only limited to made description.
Embodiment 1
A kind of Chinese medicine composition for treating stomachache, raw material are 3~5 parts of Fructus cinnamomi camphorae monomer, spiced blood in parts by weight
6~10 parts of rattan monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~1.6, fist
0.9~4.5 part of monomer of ginseng.
The Fructus cinnamomi camphorae monomer is 1, 8-Cineole, and longpeduncle kadsura stem monomer is five lactone E, and paniculate swallowwort monomer is tree peony
Phenol, evodia rutaecarpa monomer are evodene, and tinosporae monomer is tinosporine, adder-wort monomer is gallic acid；
It after obtaining drug according to above-mentioned formula ratio, is mixed, it is tabletted that auxiliary material is added；
The auxiliary material is starch.
Embodiment 2
A kind of Chinese medicine composition for treating stomachache, raw material are 3~5 parts of Fructus cinnamomi camphorae monomer, spiced blood in parts by weight
6~10 parts of rattan monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~1.6, fist
0.9~4.5 part of monomer of ginseng.
The Fructus cinnamomi camphorae monomer is 1, 8-Cineole, and longpeduncle kadsura stem monomer is five lactone E, and paniculate swallowwort monomer is tree peony
Phenol, evodia rutaecarpa monomer are evodene, and tinosporae monomer is tinosporine, adder-wort monomer is gallic acid；
It after obtaining drug according to above-mentioned formula ratio, is mixed, it is tabletted that auxiliary material is added；
The auxiliary material is microcrystalline cellulose.
Embodiment 3
A kind of Chinese medicine composition for treating stomachache, raw material are 3~5 parts of Fructus cinnamomi camphorae monomer, spiced blood in parts by weight
6~10 parts of rattan monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~1.6, fist
0.9~4.5 part of monomer of ginseng.
The Fructus cinnamomi camphorae monomer is 1, 8-Cineole, and longpeduncle kadsura stem monomer is five lactone E, and paniculate swallowwort monomer is tree peony
Phenol, evodia rutaecarpa monomer are evodene, and tinosporae monomer is tinosporine, adder-wort monomer is gallic acid；
It after obtaining drug according to above-mentioned formula ratio, is mixed, it is tabletted that auxiliary material is added；
The auxiliary material is beta-cyclodextrin.
Embodiment 4
A kind of Chinese medicine composition for treating stomachache, raw material are 3~5 parts of Fructus cinnamomi camphorae monomer, spiced blood in parts by weight
6~10 parts of rattan monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~1.6, fist
0.9~4.5 part of monomer of ginseng.
The Fructus cinnamomi camphorae monomer is 1, 8-Cineole, and longpeduncle kadsura stem monomer is five lactone E, and paniculate swallowwort monomer is tree peony
Phenol, evodia rutaecarpa monomer are evodene, and tinosporae monomer is tinosporine, adder-wort monomer is gallic acid；
It after obtaining drug according to above-mentioned formula ratio, is mixed, auxiliary material is added and is prepared into capsule；
The auxiliary material is starch.
Embodiment 5
A kind of Chinese medicine composition for treating stomachache, raw material are 3~5 parts of Fructus cinnamomi camphorae monomer, spiced blood in parts by weight
6~10 parts of rattan monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~1.6, fist
0.9~4.5 part of monomer of ginseng.
The Fructus cinnamomi camphorae monomer is 1, 8-Cineole, and longpeduncle kadsura stem monomer is five lactone E, and paniculate swallowwort monomer is tree peony
Phenol, evodia rutaecarpa monomer are evodene, and tinosporae monomer is tinosporine, adder-wort monomer is gallic acid；
It after obtaining drug according to above-mentioned formula ratio, is mixed, auxiliary material is added and is prepared into capsule；
The auxiliary material is microcrystalline cellulose.
Contain schizandrin A in the longpeduncle kadsura stem.
The weight ratio of five lactone E and schizandrin A is 1 in the longpeduncle kadsura stem monomer：0.015.
Embodiment 6
A kind of Chinese medicine composition for treating stomachache, raw material are 3~5 parts of Fructus cinnamomi camphorae monomer, spiced blood in parts by weight
6~10 parts of rattan monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~1.6, fist
0.9~4.5 part of monomer of ginseng.
The Fructus cinnamomi camphorae monomer is 1, 8-Cineole, and longpeduncle kadsura stem monomer is five lactone E, and paniculate swallowwort monomer is tree peony
Phenol, evodia rutaecarpa monomer are evodene, and tinosporae monomer is tinosporine, adder-wort monomer is gallic acid；
It after obtaining drug according to above-mentioned formula ratio, is mixed, beta-cyclodextrin is added and is prepared into capsule；
Contain schizandrin A in the longpeduncle kadsura stem.
The weight ratio of five lactone E and schizandrin A is 1 in the longpeduncle kadsura stem monomer：0.02.
In above-described embodiment, the preparation method of tablets and capsules is disclosed only, but be not limited to capsule in the present invention
Agent and tablet are also possible to a series of pharmaceutical preparations for being clinically suitable for such as pill, powder, electuary.
Test example 1：
Analgesic effect test：
Drug：Test is divided into 7 groups, and wherein A, B, C group are the tablet of Examples 1 to 3 preparation, and D, E, F group are embodiment 4
The capsule of~6 preparations, G group are the capsule of patent CN100488534C preparation；
Animal；Kunming mouse, 18-24g, half male and half female；Wistar rat, 80~100g, half male and half female, is purchased from Kweiyang
Laboratory animal center of medical college；
1-1：To the analgesic activity (hot plate method, writhing method) of mouse：Female KM kind mouse is taken, by being only put into G-8402 type
In hot plate pain threshold detector, measures and record the time required to mouse occurs licking metapedes (s) and three times, make even as the mouse pain threshold, tie-in
Mean value selects mouse 80 within 5s-30s of pain threshold, is randomly divided into 8 groups as pain threshold before the mouse normal value or medicine,
Dosage is：Drug A/B/C/D/E/F/G each group is respectively 0.20g/kg, and physiological saline group gives isometric(al) physiology salt
Water, 30 after medicine, 60, each mouse pain threshold of 90min measurement, if mouse is taken out in hot-plate instrument 60S still analgesia reaction, pain threshold
Based on 60s, 1 the results are shown in Table；
Kunming mouse 80 separately are taken, is randomly divided into 8 groups, is administered by aforementioned dosage, each mouse of lh after administration is distinguished
Be injected intraperitoneally 0.7% acetum O.2ml/ only, observe 15min in each group mouse writhing response number as caused by acetic acid, knot
Fruit is shown in Table 1；
1 present composition of table is to mouse analgesic activity (± s) n=10)
Invention formulation group is compared with physiological saline group, P < 0.01, has significance difference anisotropic；Compared with G group capsule, P
<0.05；
By upper watch test it is found that under identical drug dose, the analgesic effect of invention formulation compares patent
Capsule disclosed in CN100488534C is good, it was demonstrated that invention formulation has good analgesic effect.
Test example 2
Antiulcer effect test：
2-1：Kunming mouse, 18-24g, half male and half female；Wistar rat, 80~100g, half male and half female, is purchased from Kweiyang
Laboratory animal center of medical college；
2-3：It is 80 total using above-mentioned mouse, 8 groups are randomly divided into, drug A/B/C/D/E/F/G each group is respectively
0.20g/kg, blank group give equal volume distilled water, and once a day, continuous 5 times, mouse is bundled in by 1h respectively after the last administration
On special iron wire net rack, then each mouse is placed in same water tank (23 ± 0.5 DEG C), is not interfere with each other between each mouse, the depth of water is extremely
At xiphoid-process, animal to be taken out for 24 hours, neck is taken off and puts to death, and opens abdominal cavity, door and pylorus are spoiled in ligation, and 1% formalin 1ml is injected into stomach,
Stomach is cut and is immersed in 10% formalin, 30min takes out, and cuts off stomach along greater curvature, observes glandular stomach Area of ulcer, counts ulcer
Index the results are shown in Table 2；
Table 2：Influence (X ± s, n=10) of the invention formulation to murine lesion
| Group | Ulcer index | Percentage % occurs for ulcer |
| A | 20.6±4.3 | 21.7 |
| B | 21.8±3.9 | 17.1 |
| C | 22.3±3.7 | 15.2 |
| D | 22.7±2.8 | 13.7 |
| E | 22.8±3.5 | 13.3 |
| F | 23.4±4.1 | 11.0 |
| G (control group) | 18.1±5.3 | 31.2 |
| Blank group | 26.3±4.3 | 100 |
Invention formulation group is compared with blank group group, P < 0.01, has significance difference anisotropic；Compared with G group capsule, P<
0.01, there is significant otherness；
By upper watch test it is found that invention formulation obviously compares patent to the inhibiting effect of murine lesion
Capsule disclosed in CN100488534C is good, it was demonstrated that invention formulation has good antiulcer effect.
Test example 3：
3-1 clinical observation and curative effect：
In January, 2012~2013 year December is collected in the tested case of the court patient 114, as research object, wherein male
Property 80, women 60；Age be 25~45 years old, average age (35.65 ± 2.35) year；The course of disease 6 months~2.5 years；At random
It is divided into 7 groups, wherein A group 24, B group 20, C group 16, D group 18, E group 22, F group 20, control group (patent
CN100488534C) 20, for all patients according to age, gender, the course of disease, clinical symptoms etc., each group is equal in terms of general information
There was no significant difference, is comparable；
3-2 diagnostic criteria：Reference《Chinese medicine disease diagnosis and treatment standard and with prescription select》And《Common disease diagnosis basis and curative effect
Judgement diagnosis》：Gastrocopy finds gastric mucosa congestion oedema, ulcer surface and blutpunkte, rotten to the corn point；Stomach lining and gastric juice urease
It is the positive that quick diagnosis test paper method, which tests helicobacter pylori (HP),；With gastral cavilty portion distending pain, burning heat sensation, repeatedly acid regurgitation, hiccup
Equal digestive symptoms etc., meet above-mentioned condition, can be diagnosed as chronic gastritis and make a definite diagnosis；
3-3 method：Wherein invention formulation be A/B/C/D/E/F group, daily drug 5g/ times of the present invention, control group
It is as a treatment course according to 4 weeks using pharmaceutical preparation 5g/ times of patent CN100488534C preparation, continuously take 3 course for the treatment of；
3-4 efficacy determination：
It is effective：After treatment, helicobacter pylori checks that feminine gender, clinical symptoms and sign restore normal, fibergastroscopy stomach
Mucous membrane foci disappearance；Effectively：After treatment, helicobacter pylori checks that feminine gender, clinical symptoms and sign are improved in varying degrees, fiber
Gastrocopy gastric mucosa lesion has different degrees of improvement；In vain：After treatment, helicobacter pylori checks positive, clinical symptoms, sign
Stomach function regulating mucous membrane lesion is unchanged or aggravates；As a result as shown in table 3 below：
3 each group clinical effectiveness of table statistics
By upper watch test result it is found that after the drug therapy of 3 courses for the treatment of, most of Patients with Chronic Gastritis occur
The symptoms tool such as sour regurgitation, belch, appetite stimulator, abdomen swelling, hiccup improve significantly, and helicobacter pylori checks as yin
Property, gastric mucosa lesion has different degrees of improvement, wherein the total effective rate of pharmaceutical preparation of the present invention is 70% or more, and right
Total effective rate according to group pharmaceutical preparation is 65%, it follows that using pharmaceutical preparation of the present invention in terms for the treatment of gastritis disease
Clinical effectiveness is significant, and each group is over the course for the treatment of, there are no adverse reaction；In addition, in two groups of E/F, due to being added with
Schizandrin A, compared to tetra- groups of A/B/C/D, therapeutic effect is more significant.
It is important to point out that, above embodiments and test example are only limitted to do further technical solution of the present invention herein
Elaboration and understanding, should not be understood as it is further to technical solution of the present invention limited, what those skilled in the art made
The innovation and creation of non-protruding essential characteristics and marked improvement still fall within protection category of the invention.
Claims (7)
1. a kind of Chinese medicine composition for treating stomachache, which is characterized in that raw material be in parts by weight 3~5 parts of Fructus cinnamomi camphorae list,
6~10 parts of longpeduncle kadsura stem monomer, 1.2~3.6 parts of paniculate swallowwort monomer, 0.9~2.7 part of evodia rutaecarpa monomer, tinosporae monomer 0.3~
1.6,0.9~4.5 part of adder-wort monomer.
2. the Chinese medicine composition for the treatment of stomachache as described in claim 1, which is characterized in that the raw material is big fruit in parts by weight
4 parts of Litsea pungens list, 8 parts of longpeduncle kadsura stem monomer, 2.5 parts of paniculate swallowwort monomer, 1.8 parts of evodia rutaecarpa monomer, 1.2 parts of tinosporae monomer,
2.5 parts of adder-wort monomer.
3. the Chinese medicine composition for the treatment of stomachache as claimed in claim 1 or 2, which is characterized in that the Fructus cinnamomi camphorae monomer is
1, 8-Cineole, longpeduncle kadsura stem monomer are five lactone E, and paniculate swallowwort monomer is paeonol, and evodia rutaecarpa monomer is evodene, Jin Guo
Olive monomer is tinosporine, adder-wort monomer is gallic acid.
4. the Chinese medicine composition for the treatment of stomachache as claimed in claim 3, which is characterized in that contain Schisandra chinensis in the longpeduncle kadsura stem
A prime.
5. the Chinese medicine composition for the treatment of stomachache as claimed in claim 1 or 2, which is characterized in that five in the longpeduncle kadsura stem monomer
The weight ratio of lactone E and schizandrin A is 1：(0.015~0.02).
6. treating the Chinese medicine composition of stomachache as described in any one of Claims 1 to 5, which is characterized in that the composition is
Any preparation for being clinically suitable for.
7. purposes of the Chinese medicine composition in treatment stomachache drug as described in any one of Claims 1 to 5.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110269885A (en) * | 2019-06-06 | 2019-09-24 | 中国人民解放军南部战区总医院 | Radix Tinosporae extract is preparing the application in overriding resistance Acinetobacter bauamnnii drug |
| CN116270489A (en) * | 2023-03-22 | 2023-06-23 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110269885A (en) * | 2019-06-06 | 2019-09-24 | 中国人民解放军南部战区总医院 | Radix Tinosporae extract is preparing the application in overriding resistance Acinetobacter bauamnnii drug |
| CN116270489A (en) * | 2023-03-22 | 2023-06-23 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
| CN116270489B (en) * | 2023-03-22 | 2023-09-08 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
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| CN108836961B (en) | 2021-02-12 |
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Denomination of invention: A Chinese medicine composition for treating stomachache Effective date of registration: 20221228 Granted publication date: 20210212 Pledgee: Agricultural Bank of China Limited Zunyi Branch Pledgor: Guizhou Wansheng Pharmaceutical Co.,Ltd. Registration number: Y2022980028911 |
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